Podcasts about nikolaus

Wie finden Patienten das richtige Krankenhaus? Nicht nur das Gesundheitsministerium, auch Verlage wollen mit Rankings und Siegeln Orientierung bieten. Doch die Kriterien sind oft unklar und teils wahllose Bewertungen beeinflussen den Wettbewerb. Nützel, Nikolaus www.deutschlandfunk.de, Hintergrund

Frenzel, Korbinian www.deutschlandfunkkultur.de, Studio 9 - Der Tag mit ...

Kreuzestod und Auferstehung Jesu bilden das Fundament des christlichen Glaubens. Insofern der Kreuzestod aber als Zeichen der Gottverlassenheit verstanden wurde (vgl. Dtn 21,23), die Auferstehung aber nur gottgewirkt sein kann, stellt die gottgewirkte Auferstehung des Gottverlassenen ein Paradox dar. Dies führt zur Frage danach, wer Jesus von Nazareth ist. Diese sogenannte "christologische Frage" wurde in der frühene Kirche streitbar diskutiert und führte im Jahr 325 n.d.Z. - vor 1.700 Jahren - zum Konzil von Nicäa, dessen Glaubensbekenntnis bis heute die Christenheit über alle Konfessionen hinweg verbindet. Gleichwohl war die Diskussion nicht beendet. Interpretationen einzelner Glaubensartikel führten zur Konfesssionalisierung des Christentums. Auch die christologische Diskussion wurde fortgeführt und stellt heute nicht zuletzt im interreligiösen Diskurs - etwa mit dem Islam - eine bedeutende Thematik dar. Mitschnitt der Glaubensinformation mit Dr. Werner Kleine, die am 3. September 2025 als Webinar stattfand. Weiterführende Links: Werner Kleine, Das Credo - Was Christen glauben (Glaubensinformation), Youtube, 17.8.2022 Werner Kleine, Nikolaus von Myra - Bischof, Konzilsvater von Nicäa und Legende (Glaubensinformation), Youtube, 4.12.2024 Die 20 Kanones von Nicäa: Kanon 1: Eunuchen können – außer wenn sie sich selbst kastriert haben – Priester werden. Hingegen kann niemand, der sich selbst kastriert hat, Kleriker werden oder bleiben. Kanon 2: Leute, die nach kurzem Katechumenat entgegen 1 Tim 3,6–7 EU gleichzeitig mit der Taufe zum Priester oder Bischof geweiht wurden, können ihren Status behalten, aber in Zukunft soll das nicht mehr vorkommen. Wenn ein so geweihter Geistlicher von zwei oder drei Zeugen einer Sünde überführt wird, soll er aus dem Klerus entfernt werden. Kanon 3: Das Konzil verbietet absolut, dass Bischöfe, Priester und Diakone mit einer Frau (als Syneisakte) zusammenleben, ausgenommen ihre Mutter, Schwester oder Tante oder eine andere über jeden Verdacht erhabene Frau. Kanon 4: Ein Bischof soll von allen Bischöfen der Provinz geweiht werden. Wenn dies nicht praktikabel ist, sollen mindestens drei Bischöfe die Ordination vornehmen, nachdem die übrigen schriftlich ihr Einverständnis gegeben haben. In jedem Fall steht dem Metropolitan das Recht zu, das Vorgehen zu bestätigen. Kanon 5: Die Exkommunikation eines Priesters oder Laien muss durch die Bischöfe aller Provinzen respektiert werden. Es soll jedoch eine Untersuchung durch die übrigen Bischöfe der Provinz geben, um sicherzustellen, dass niemand aus persönlichen Gründen von einem Bischof exkommuniziert wurde. Um diese Untersuchungen geordnet durchzuführen, sollen die Bischöfe jeder Provinz zweimal jährlich zu einer Synode zusammentreten. Kanon 6: Die althergebrachte Autorität der Bischöfe von Alexandria, Antiochia und Rom über ihre Provinzen wird bestätigt. Eine Bischofswahl ohne Zustimmung des Metropolitans ist ungültig. Wenn es jedoch unter den wählenden Bischöfen zwei oder drei Gegenstimmen gibt, entscheidet die Mehrheit. Kanon 7: Der Bischof von Aelia (Jerusalem) soll nach altem Brauch geehrt werden, ohne jedoch die Rechte des Metropolitans einzuschränken. Kanon 8: Geistliche der Novatianer, die öffentlich in die Kirche eintreten, dürfen ihren geistlichen Rang behalten, wenn sie sich schriftlich dazu verpflichten, die Dekrete der Kirche zu akzeptieren und zu befolgen. Sie sind jedoch im Rang allfälligen örtlichen Geistlichen der Kirche untergeordnet. Kanon 9: Wenn Leute ohne Prüfung zum Priester geweiht wurden und nachträglich eine Sünde bekennen, die sie dafür disqualifiziert, ist die Priesterweihe ungültig. Kanon 10: Wenn entdeckt wird, dass ein Priester seinerzeit unter der Verfolgung abgefallen ist und nachträglich zum Priester geweiht wurde, ist die Priesterweihe ungültig. Kanon 11: Wenn Leute ohne Gefahr vom Glauben abgefallen sind, sollen sie milde behandelt werden, obwohl sie keine solche Milde verdienen: Sie sollen nach einer Buße von zwölf Jahren wieder zur Kommunion zugelassen werden. Kanon 12: Wenn Christen, die erst auf den Militärdienst verzichtet haben, zur Armee zurückgekehrt sind, sollen sie nach dreizehn Jahren Buße wieder zur Kommunion zugelassen werden. Diese Bußzeit kann jedoch im Fall von echter Reue durch den Bischof verkürzt werden. Kanon 13: Einem Sterbenden darf die Eucharistie gegeben werden, wenn er danach verlangt, auch wenn er nicht zur Kommunion zugelassen war. Kanon 14: Katechumen, die abgefallen sind, dürfen nach einer Bußzeit von drei Jahren wieder mit den Katechumenen beten. Kanon 15: Bischöfe, Priester und Diakone dürfen nicht von Stadt zu Stadt wandern, sondern sollen, wenn sie das versuchen, zu der Kirche zurückgeschickt werden, wo sie ordiniert wurden. Kanon 16: Priester und Diakone, die ihre Kirche verlassen, dürfen nicht von einer anderen Kirche aufgenommen werden. Bischöfe dürfen niemanden ordinieren, der zu einer andern Diözese gehört. Kanon 17: Wer Wucherzinsen verlangt, soll abgesetzt werden. Kanon 18: Diakone dürfen die Eucharistie nicht Priestern geben, sondern sollen die Eucharistie von Bischof oder Priester empfangen. Kanon 19: Anhänger von Paul von Samosata, die bei der Kirche Zuflucht suchen, sollen in jedem Fall neu getauft werden. Geistliche können nach Prüfung neu ordiniert werden. Diakoninnen sollen nicht zum Klerus, sondern zu den Laien gezählt werden. Kanon 20: Am Sonntag und in der Pfingstzeit soll nicht kniend, sondern stehend gebetet werden.

Nützel, Nikolaus www.deutschlandfunk.de, Tag für Tag

Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

Nützel, Nikolaus www.deutschlandfunk.de, @mediasres

Progressive supranuclear palsy and corticobasal syndrome are closely related neurodegenerative disorders that present with progressive parkinsonism and multiple other features that overlap clinically and neuropathologically. Early recognition is critical to provide appropriate treatment and supportive care. In this episode, Teshamae Monteith, MD, FAAN speaks with Nikolaus R. McFarland, MD, PhD, FAAN, author of the article “Progressive Supranuclear Palsy and Corticobasal Syndrome” in the Continuum® August 2025 Movement Disorders issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. McFarland is an associate professor of neurology at the University of Florida College of Medicine at the Norman Fixel Institute for Neurological Diseases in Gainesville, Florida. Additional Resources  Read the article: Progressive Supranuclear Palsy and Corticobasal Syndrome Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Monteith: Hi, this is Dr Teshamae Monteith. Today I'm interviewing Dr Nikolaus McFarland about his article on progressive supranuclear palsy and cortical basilar syndrome, which appears in the August 2025 Continuum issue on movement disorders. Welcome, how are you? Dr Farland: I'm great. Thank you for inviting me to do this. This is a great opportunity. I had fun putting this article together, and it's part of my passion. Dr Monteith: Yes, I know that. You sit on the board with me in the Florida Society of Neurology and I've seen your lectures. You're very passionate about this. And so why don't you first start off with introducing yourself, and then tell us just a little bit about what got you interested in this field. Dr Farland: I'm Dr Nicholas McFarlane. I'm an associate professor at the University of Florida, and I work at the Norman Fixel Institute for Neurological Diseases. I am a director of a number of different centers. So, I actually direct the cure PSP Center of Care and the MSA Center of Excellence at the University of Florida; I also direct the Huntington's clinic there as well. But for many years my focus has been on atypical parkinsonisms. And, you know, I've treated these patients for years, and one of my focuses is actually these patients who suffer from progressive supranuclear palsy and corticobasal syndrome. So that's kind of what this review is all about. Dr Monteith: You probably were born excited, but I want to know what got you interested in this in particular? Dr Farland: So, what got me interested in this in particular was really the disease and the challenges that's involved in it. So, Parkinson's disease is pretty common, and we see a lot of that in our clinic. Yet many times, roughly about 10 to 15% of my patients present with these atypical disorders. And they're quite fascinating. They present in different ways. They're fairly uncommon. They're complex disorders that progress fairly rapidly, and they have multiple different features. They're sort of exciting to see clinically as a neurologist. I think they're really interesting from an academic standpoint, but also in the standpoint of really trying to bring together sort of a team. We have built a multidisciplinary team here at the University of Florida to take care of these patients. They require a number of folks on that team to take care of them. And so, what's exciting, really, is the challenge of treating these patients. There are very limited numbers of therapies that are available, and the current therapies that we have often really aren't great and over time they fail. And so, part of the challenge is actually doing research. And so, there's actually a lot of new research that's been going on in this field. Recently, there's been some revisions to the clinical criteria to help diagnose these disorders. So, that's really what's exciting. The field is really moving forward fairly rapidly with a number of new diagnostics, therapeutics coming out. And hopefully we can make a real difference for these patients. And so that's what really got me into this field, the challenge of trying to treat these patients, help them, advocate for them and make them better. Dr Monteith: And so, tell me what the essential points of this article. Dr Farland: So, the essential points, really, of this article is: number one, you know, just to recognize the new clinical criteria for both PSP and corticobasal syndrome, the diagnosis for these disorders or the phenotypic spectrum has really expanded over the years. So, we now recognize many different phenotypes of these disorders, and the diagnosis has gotten fairly complicated. And so, one of the goals of this article was to review those new diagnostic criteria and the different phenotypic ways these diseases present. I wanted to discuss, also, some of the neuropathology and clinicopathological overlap that's occurred in these diseases as well as some of the new diagnostic tests that are available. That's definitely growing. Some of the new studies that are out, in terms of research and clinical trials. And then wanted to review some of the approaches for treatment for neurologists. Particularly, we're hoping that, you know, this article educates folks. If you're a general neurologist, we're hoping that recognizing these diseases early on will prompt you to refer these patients to specialty clinics or movement disorder specialists early on so they can get appropriate care, confirm your diagnosis, as well as get them involved in trials if they are available. Dr Monteith: And how has the clinical criteria for PSP and cortical basilar syndrome changed? Dr Farland: I think I already mentioned there's been an evolution of the clinical criteria for PSP. There's new diagnostic criteria that were recently published, and it recognizes the multiple clinical phenotypes and the spectrum of the disease that's out there, which is much broader than we thought about. Corticobasal clinical criteria are the Dr Armstrong criteria from 2013. They have not been updated, but they are in the works of being updated. But it does recognize the classic presentation of corticobasal syndrome, plus a frontal executive predominant and then a variant that actually overlaps with PSP. So, there's a lot more overlap in these two diseases than we originally recognized. Dr Monteith: And so, you spoke a bit about FTD spectrum. So why don't you tell us a little bit about what that is? I know you mentioned multiple phenotypes. Dr Farland: What I really want to say is that both PSP and corticobasal syndrome, they're relatively rare, and what- sort of as to common features, they both are progressive Parkinson disorders, but they have variable features. While they're commonly associated with Parkinson's, they also fit within this frontotemporal lobar spectrum, having features that overlap both clinically and neuropathologically. I just want folks to understand that overlap. One of this pathological overlap here is the predominant Tau pathology in the brain, an increasing recognology- recognition of sort of the pathological heterogeneity within these disorders. So, there's an initial description, a classic of PSP, as Richardson syndrome. But now we recognize there are lots of different features to it and there are different ways it presents, and there's definitely a lot of clinical pathological overlap. Dr Monteith: Why don't we just talk about some red flags for PSP? Dr Farland: Yeah, sure. So, some of the red flags for PSP and even corticobasal syndrome are: number one is rapid progression with early onset of falls, gait difficulty, falling typically backwards, early speech and swallow problems that are more prominent than you see in Parkinson's disease, as well as eye gaze issues. So, ocular motor features, particularly vertical gaze palsy. In particular what we talk about is the supranuclear gaze palsy, and one of the most sensitive features that we've seen with these is downgaze limitation or slowed downgaze, and eventually a full vertical gaze palsy and followed supranuclear gaze palsy. So, there's some of the red flags that we see. So, while we think about the lack of response to levodopa frequently as something that's a red flag for Parkinson's, there are many times that we see Parkinson's patients, and about a quarter of them don't really respond. There's some features that don't respond to levodopa that may not be so specific, but also can be helpful in this disease. Dr Monteith: And what about the red flags for cortical basilar syndrome? Dr Farland: So, for cortical basilar syndrome, some of the red flags again are this rapidly depressive syndrome tends to be, at least in its classical present presentation, more asymmetric in its presentation of parkinsonism, with features including things like dystonic features, okay? For limb dystonia and apraxias---so, inability to do a learned behavior. One of those red flags is a patient who comes in and says, my hand doesn't work anymore, which is something extremely uncommon that you hear in Parkinson's disease. Most of those patients will present, say, I might have a tremor, but they very rarely will tell you that I can't use my hand. So look out for that sign. Dr Monteith: And let's talk a little bit about some of the advances in the fields you mentioned, evolving biomarker and imaging capacities. So, how are these advances useful in helping us understand these conditions, especially when there's so much heterogeneity? Dr Farland: I might start by talking a little bit about some of the clinical criteria that have advanced. Why don't we start there and just discuss some of the advances? I think in PSP, I think, originally we had both probable and possible diagnoses of PSP, and the diagnostic criteria were basically focused on what was what's called “classical PSP” or “Richardson syndrome”. But now we recognize that there are multiple phenotypes. There's an overlap with Parkinsonism that's slower in progression and morphs into PSP, the classical form. There's a frontal behavioral variant where patients present with that frontal behavioral kind of thing. There's a speech-language variant that can overlap with PSP. So they have prominent speech language, potentially even apraxia speech. So, recognition of these different phenotypes is sort of a new thing in this field. There's even overlap with cortical basal syndrome and PSP, and we note that the pathology can overlap as well. So, I think that's one of the things that have changed over time. And these were- recently came out in 2017 in a new publication in the Movement Disorders Society. So, in terms of diagnostic tests as well---and there's been quite a bit of evolution---really still to date, our best diagnostic test is imaging. MRI is really one of our best tests currently. Currently blood tests, spinal fluid, there's new biomarkers in terms of skin… they're still in the research phase and not necessarily very specific yet. So, we rely heavily on imaging still; and for PSP, what we're looking for largely are changes in the brain stem, and particularly focused on the midbrain. So disproportionate midbrain atrophy compared to the pons and the rest of the midbrain is a fairly specific intensive sign for PSP. Whereas in MSA we see more of a pontine atrophy compared to the midbrain. So that can be really helpful, and there are lots of different new measurements that can be done. PET scans are also being used as well. And there are new PET markers, but they still remain kind of research-based, but are becoming more and more prevalent and may be available soon for potential use. Although there's some overlap with PET tracers with Alzheimer's disease and different Tau isoforms. So, something to be wary about, but we will be seeing some of these soon coming out as well. More kind of up-to-date things include things like the spinal fluid as well as even some of the skin biopsies. And I think we've heard some word of recent studies that have come out that potentially in the very near future we might actually have some Tau protein tests that we can look at Tau either in spinal fluid or even in a skin biopsy. But again, still remains research-based and, we still need more information as to whether these tests can be reproducible and how sensitive or specific they are. Dr Monteith: It sounds like, when really approaching these patients, still, it's a lot of back to the history, back to the clinical and some basic imaging that we should be able to identify to distinguish these types of patients, and we're not quite where we need to be yet for biomarker. Dr Farland: I totally agree with you. I think it starts, really, with the clinical exam and that's our main focus here; and understanding some of the new clinical criteria which are more sensitive, but also specific, too. And they're really useful to look at. So, I think reviewing those; patients do progress, following them over time can be really useful. And then for diagnosis, getting imaging if you suspect a patient has an atypical presentation of parkinsonism, to look for signs or features that might be specific for these different disorders. Dr Monteith: Why don't we take a typical case, a typical patient that you would see in clinic, and walk us through the thought process---especially, maybe they presented somewhat early---and the different treatment approaches to helping the patient, and of course their family. Dr Farland: Yeah, sure. So, a typical patient might be someone who comes in with, like, a three year history of progressive gait problems and falling. And let's say the patient says, I'm falling backwards frequently. They may have had, like, a rib fracture, or they hit their head once, and they're describing some speech issues as well. Now they're relying on a walker and family members saying they rarely let them be by themselves. And there may be some slowing of their cognitive function and maybe a bit of withdrawal. So that's a typical patient. So, the approach here is really, what are some of the red flags? I think already you hear a red flag of a rapidly progressive disease. So, Parkinson's disease patients rarely have frequent falls within the first five years. So, this is within three years or less. You're already hearing early onset of gait problems and falling, and particularly falling backwards rather than forwards as often Parkinson's disease patients do. You're hearing early speech problems and maybe a subtle hint of cognitive slowing and some withdrawal. So, a lot of things that sort of are red flags. So, our approach really would be examining this patient really closely. Okay? We'd be listening to the history, looking at the patient. One thing is that some of these patients come in, they may be in a wheelchair already. That's a red flag for us. If they're wearing sunglasses---sometimes we see that patients, they have photosensitivity and they're in a chair and they're wearing sunglasses---you take the glasses off and you look at their face and they have that sort of a facial stare to them---not just the masked face, but the stare---and their eyes really aren't moving. So, another kind of clue, maybe this is probably something atypical, particularly PSP is what I'm thinking about. So, the approach is really, do a thorough exam. I always recommend looking at eye movements and starting with volitional saccades, not giving them a target necessarily, but asking them to look up and then look down. And then particularly look at the speed of downgaze and whether they actually have full versions down, are able to do that. That's probably your most sensitive test for a patient who has PSP. Not the upgaze, which can be- upgaze impairment in older patients can be nonspecific. So, look for that down gaze. So, if I can get out one message, that's one thing that can be easily done and examined fairly quickly for diagnosis of these patients. And then just look for signs of rigidity, bradykinesia, maybe even some myelopraxia, and then look at their gait carefully so that there's a high suspicion. Again, if there's some atypical features, imaging is really important. So, my next step would be probably getting an MRI to evaluate whether- do they have brain somatrophy or other widespread atrophy or other signs? You need to think about your differential diagnosis for some of these patients as well. So, common things are common; vascular disease, you can't have vascular parkinsonism or even signs of NPH. Both of those can present with progressive gait difficulty and falls. So, the gait may look more like Parkinson's rather than ataxic gait that we see in classic PSP, but still they have early gait issues, and that can be a mimicker of PSP, So looking for both of those things in your imaging. Think about sort of autoimmune potentially causes. So, if they have a really rapid progressive cause, there are some rare autoimmune things. There have been recent reports of things like IgLON5, although there's limited cases, but we're doing more screening for some of those autoimmune causes. And then even some infectious causes like Whipples, that are rarely present like this. Okay? And have other signs and features. Dr Monteith: So, let's say you diagnose this patient with PSP and you're assessing the patients to see how you can improve their quality of life. So, what are some potential symptomatic managements that will help our patient? Dr Farland: I recommend for most all of these patients… while the literature indicates that many patients with PSP, and especially corticobasal syndrome, don't respond well to levodopa. So, the classic treatment for parkinsonism. However, we all recommend a trial of levodopa. These patients may respond partially to doses of levodopa, and we try to push the doses a bit higher. So, the recommended trial is usually a dose up to roughly 1000 milligrams of levodopa per day. And give it some time, at least two, if not actually three months of a trial. If not well-tolerated, you can back off. If there's no response at all or no improvement, then slowly back off and taper patients off and ask them to tell you whether they feel like they're actually worsening. So, many patients, sometimes, don't recognize the improvements, or family members don't recognize it until we actually taper them back off. And they may end up saying there are some other things that even recognize. Even some nonmotor benefits can be seen with levodopa. In some cases, we do keep them on levodopa, but levodopa's our best therapy for this. Dopamine agonists, MAO inhibitors, have all been sort of tried and they've been studied, but often don't really help or fail to help benefit these patients and could be fraught with some other side effects. I think many people do also turn to Amantadine as a treatment for Parkinson's, gait problems, freezing, if you see it in these disorders. Yet Amantadine is fraught with issues of side effects, including cognitive issues, and I think is not well-tolerated. But there are the rare patient who actually does respond to this or claims they respond to this. By and large, these patients relentlessly progress, unfortunately. So, beside treatment of other symptoms, I think it's really important to recognize that they require supportive cares and therapy. So, starting those early on and getting your allied healthcares kind of involved. So that includes people like physical, occupational therapy for the gait issues, the falls, occupational therapy for doing daily activities. Speech language pathology can be really a critical player for these because of the early speech and language issues, as well as swallow difficulties. Swallow is compared quickly in these patients. And so, we do recommend the screening evaluation, then often following patients either every six- or even annually, at least, with a swallow evaluation. And we recommend the fluoroscopic-guided kind of modified barium swallow for these patients.  Dr Monteith: And how does that differ if, let's say, the patient had cortical basilar syndrome? What are some of the symptomatic treatments that would be high on your consideration? Dr Farland: So actually, these patients also have a very similar approach, and they often have some overlapping features. Maybe a little bit of difference in terms of the level of apraxia and some dystonic features that you see in corticobasal syndrome. So, as I mentioned earlier that these patients have a more typ- when they present, typically have a more asymmetric presentation. And one of the biggest issues is this limb apraxia. They may have abnormal movements as well as, like, the alien limb-type phenomena as well. So, the focus of therapy, while similar in the sense we focus on the parkinsonism, I do always try levodopa and try to ramp up the doses to see if it benefits. It does often fail, but it's definitely worth trying. The other focus of these patients is trying to treat symptoms. Dystonia, those features… in some cases, we can help; if it's painful or uncomfortable, muscle relaxants can be used. If it's vocal, things like Botox can be really helpful. Often times it is more palliative than actually restorative in terms of function, but still can be really helpful for patients who ask about pain and discomfort and trying to treat. And then of course, again, the focus on our supportive care. We need to build that network and build that team of folks, the therapists, the physical, occupational, and the speech therapist to help them. If they have language problems---like either in PSP or corticobasal---I'll also include my request to a speech language pathologist to work on cognitive function. That's a special, additional thing you have to ask for and then specifically request when you make a referral to a speech language pathologist. Dr Monteith: That is so important. I think keeping the simulation, keeping the social support, and I would probably guess that you would also include screening for sleep and mood disorder. Dr Farland: Absolutely. Mood disorders are really big in these diseases. Patients are suffering terribly. You do hear about labile mood in both of these diseases, particularly PSP; and even what's called pseudobulbar palsy, where the mood is not always congruent with the affect. So they may laugh or cry inappropriately, and particularly the crying can be very disturbing to family and caregivers to see that. And so, treating those things can be really important. So always asking about the mood issues. Depression in particular is something that we're very sensitive about, and there is a higher incidence of suicidal ideations. Asking about that and feeling and making sure that they are in a safe environment can be really important. Dr Monteith: Thank you so much. Dr Farland: Thank you. Dr Monteith: Today I've been interviewing Dr Nikolaus McFarland about his article on progressive supranuclear palsy and cortical basilar syndrome, which appears in the August 2025 Continuum issue on movement disorders. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Ngo, Anh-Linh www.deutschlandfunkkultur.de, Fazit

Nikolaus Thomale, Gründer von MYNE Homes, gibt dir Einblicke in den strategischen Aufbau von Teams und die richtige Finanzierungsstrategie. Er teilt, wie sie ihre Organisation in drei Kernbereiche strukturieren, warum ein früher CFO entscheidend sein kann und wie man den richtigen Mix aus Equity und Debt findet. Was du lernst: Wie du komplexe Teams effektiv strukturierst Wann der richtige Zeitpunkt für einen CFO ist Die Balance zwischen Equity und Debt-Finanzierung Wie du Banken als Finanzierungspartner gewinnst ALLES ZU UNICORN BAKERY: https://zez.am/unicornbakery  Mehr zu Nikolaus: LinkedIn: https://www.linkedin.com/in/nikolausthomale/  MYNE Homes: https://www.myne-homes.com/de  Join our Founder Tactics Newsletter: 2x die Woche bekommst du die Taktiken der besten Gründer der Welt direkt ins Postfach: https://www.tactics.unicornbakery.de/

On today's episode: Flooding cancels last day of Wisconsin State Fair as severe storms knock out power and close roads; Islamic Shariah court in Indonesia’s Aceh province sentences two men to public caning over sexual acts; Russian President Vladimir Putin is not backing down from his demands when it comes to ending the war with Urkaine; the CDC shooter blamed the COVID vaccine for depression. Trump is promising new steps to tackle homelessness and crime in Washington. European leaders rally behind Ukraine ahead of Trump-Putin meeting. Whitmer told Trump in private that Michigan auto jobs depend on a tariff change of course. Trump administration seeks $1 billion settlement from UCLA, a White House official says. Trump removes Billy Long as IRS commisioner less than 2 months after his confirmation. Astronauts return to Earth with SpaceX after 5 months at the International Space Station. Nagasaki marks 80th A-bomb anniversary as survivors put hopes of nuclear ban in the hands of youth. Apollo 13 moon mission leader James Lovell dies at 97. Previous sexual assault convict whose killing of a nurse led to safety changes sentenced to 50 years. The world’s 20th-ranked golfer rallies to claim the PGA Tour’s playoff opener, a three-time Cy Young winner eclipses another strikeout milestone, baseball’s top slugger goes deep again, an NFL player is back in the building after a scary injury and NASCAR’s star rookie secures a record victory. New England Patriots unveil Tom Brady statue at team Hall of Fame. Packers star Billy Howton, believed to have been the oldest living NFL player, dies at 95. Boston Celtics sign coach Joe Mazzulla to a multi-year contract extension. 3 elves are cycling from the German town of St. Nikolaus to Finland's Santa Claus Village. Israeli strike kills Al Jazeera correspondent Anas al-Sharif as toll on journalists in Gaza worsens. Southwest France swelters under a heat wave as fire crews guard smoldering vineyards. Australia will recognize a Palestinian state, Prime Minister Albanese says. Netanyahu defends planned military offensive in Gaza and lashes out at 'global campaign of lies'. Explosion at Lebanese arms depot kills 6 army experts, wounds several others. Police arrest demonstrators supporting the banned Palestine Action group in central London. On this week's AP Religion Roundup Gullah Geechee elders work to preserve sacred songs passed down by enslaved ancestors. —The Associated Press About this program Host Terry Lipshetz is managing editor of the national newsroom for Lee Enterprises. Besides producing the daily Hot off the Wire news podcast, Terry conducts periodic interviews for this Behind the Headlines program, co-hosts the Streamed & Screened movies and television program and is the former producer of Across the Sky, a podcast dedicated to weather and climate. Theme music The News Tonight, used under license from Soundstripe. YouTube clearance: ZR2MOTROGI4XAHRX

AP correspondent Julie Walker reports Christmas comes early to Germany.

Hinrich Baller gilt als einer der eigenwilligsten Architekten der Nachkriegszeit. Er wurde mit einer ungewöhnlichen Formensprache international bekannt, die auf rechte Winkel verzichtete. Nun ist er im Alter von 89 Jahren in Berlin gestorben. Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

Brass, Nikolaus www.deutschlandfunkkultur.de, Fazit

Helge Heynold liest: Schilflieder - von Nikolaus Lenau.

Nützel,Nikolaus www.deutschlandfunk.de, Andruck - Das Magazin für Politische Literatur

Nikolaus Schermann -Als zweiter Geschäftsführer der Hochschule Burgenland zeichnet der Südburgenländer Nikolaus Schermann unter anderem für die Vorbereitungen der Medizinischen Privatuniversität Burgenland verantwortlich. Wir servieren: Spaghetti al limone.

Who really leads the church—the pastor, the conference, or the congregation? Explore how the unique relationship among all three in the Adventist structure creates a powerful system for mission, not control.

Frenzel, Korbinian www.deutschlandfunkkultur.de, Studio 9 - Der Tag mit ...

Mit dem "Manifest" schießt der altlinke Flügel der SPD gegen die eigene Parteiführung. Es ist auch eine Rache der Beiseitegeschobenen. So geschwächt, wie sie ist, wird das bedrohlich für die SPD. Blome, Nikolaus www.deutschlandfunk.de, Kommentare und Themen der Woche

durée : 00:19:27 - Disques de légende du jeudi 12 juin 2025 - Nikolaus Harnoncourt a enregistré l'oratorio de Noël de Bach en 1973, en plein essor du jeune mouvement baroque. Plus de 30 ans après, en 2007, il grave un nouvelle version, résultat de décennies d'expérience et de réflexion.

Vor 30 Jahren verhüllte das Künstlerpaar Christo und Jeanne-Claude das Reichstagsgebäude. Die Bilder der meterlangen Stoffbahnen lockten Millionen Besucher nach Berlin. Nun soll eine Lichtprojektion an der Westfassade des Reichtstags daran erinnern. Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

Nützel, Nikolaus www.deutschlandfunkkultur.de, Studio 9

Bernau, Nikolaus www.deutschlandfunkkultur.de, Studio 9

Nützel, Nikolaus www.deutschlandfunk.de, Europa heute

Anfang des Jahres haben viele Krankenkassen ihre Beitragssätze erneut deutlich erhöht. Es gibt viele Ideen, wie sich die Beitragsspirale durchbrechen lässt. Schnelle Lösungen gibt es aber nicht. Nützel, Nikolaus www.deutschlandfunk.de, Hintergrund

Thema: Trotz Kritik weitet Israel seinen Gaza-Militäreinsatz aus

Nützel, Nikolaus www.deutschlandfunk.de, Europa heute

Acesse o Guia de bolso de IOT do TdC no link: http://bit.ly/4dyi6n8Pedro Magno e Lucca Cirillo conversam sobre os alvos de LDL em 4 populações:- Evento cardiovascular prévio- Presença de diabetes- LDL > 190 mg/dL- Outras situações Veja mais em https://www.tadeclinicagem.com.br/guia/259/hipercolesterolemia-familiar/Veja o vale a pena ouvir de novo em https://www.youtube.com/watch?v=k42rmssU1xE&ab_channel=TadeClinicagemReferências:1. Mach, François et al. “2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.” European heart journal vol. 41,1 (2020): 111-188. doi:10.1093/eurheartj/ehz4552. Faludi, André Arpad et al. “Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017.” Arquivos brasileiros de cardiologia vol. 109,2 Supl 1 (2017): 1-76. doi:10.5935/abc.201701213. Grundy, Scott M et al. “2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.” Journal of the American College of Cardiology vol. 73,24 (2019): 3168-3209. doi:10.1016/j.jacc.2018.11.0024. Pearson, Glen J et al. “2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults.” The Canadian journal of cardiology vol. 37,8 (2021): 1129-1150. doi:10.1016/j.cjca.2021.03.0165. Marx, Nikolaus et al. “2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes.” European heart journal vol. 44,39 (2023): 4043-4140. doi:10.1093/eurheartj/ehad1926. Vrints, Christiaan et al. “2024 ESC Guidelines for the management of chronic coronary syndromes.” European heart journal vol. 45,36 (2024): 3415-3537. doi:10.1093/eurheartj/ehae1777. Hong, Sung-Jin et al. “Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial.” JAMA vol. 329,13 (2023): 1078-1087. doi:10.1001/jama.2023.24878. Cannon, Christopher P et al. “Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.” The New England journal of medicine vol. 372,25 (2015): 2387-97. doi:10.1056/NEJMoa14104899. Sabatine, Marc S et al. “Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.” The New England journal of medicine vol. 376,18 (2017): 1713-1722. doi:10.1056/NEJMoa161566410. http://departamentos.cardiol.br/sbc-da/2015/calculadoraer2017/etapa1.html11. Lipidology update: targets and timing of well-established therapies, Luigina Guasti 1, MD, PhD, FAHA, FESC; Alessandro Lupi 2, MD at https://www.escardio.org/Councils/Council-for-Cardiology-Practice-(CCP)/Cardiopractice/lipidology-update-targets-and-timing-of-well-established-therapies12. Ray, Kausik K et al. “EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study.” European journal of preventive cardiology vol. 28,11 (2021): 1279-1289. doi:10.1093/eurjpc/zwaa04713. Cholesterol Treatment Trialists' (CTT) Collaboration et al. “Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.” Lancet (London, England) vol. 376,9753 (2010): 1670-81. doi:10.1016/S0140-6736(10)61350-5

Über Geld spricht man nicht? Sollte man aber, wie der unabhängige Vermögensberater Nikolaus Braun zeigt. Denn dann kann Geld unserem Leben dienen. Wie das geht, zeigt er im Gespräch mit Edith Schowalter.

Nützel, Nikolaus www.deutschlandfunk.de, Das war der Tag

Nützel, Nikolaus www.deutschlandfunkkultur.de, Studio 9

Domkapitular Theo Paul www.deutschlandfunk.de, Gottesdienst

„Istanbul, Ukraine, der Krieg – und die Hoffnung, dass es jetzt endlich was wird mit diesem Frieden“, meint Markus Lanz. Aber ist ein Ultimatum an Moskau dafür das richtige Signal? Richard David Precht hat daran große Zweifel und fragt sich, ob das politische Spitzenpersonal nicht gelernt hat, wie man richtig verhandelt. „Merz & Co. und vor allem Donald Trump haben eindrucksvoll gezeigt, wie es nicht geht. Trump hat den Nikolaus gespielt, den Sack aufgemacht und Putin gefragt, was willst du haben?“ In dieser Folge besprechen Markus Lanz und Richard David Precht, wie Kriege in der Geschichte geendet haben und sind sich einig, dass der Weg zum Frieden in der Ukraine vermutlich noch sehr lang sein wird.

durée : 00:18:48 - Disques de légende du jeudi 15 mai 2025 - Au début des années 80 paraissaient chez Teldec les Symphonies de Mozart d'Harnoncourt, avec le Concertgebouw d'Amsterdam. Un orchestre moderne pour une approche inspirée de la musique ancienne. Liberté et accomplissement.

Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

Nützel, Nikolaus www.deutschlandfunkkultur.de, Studio 9

Peters Waldspaziergang führt diesmal durch den Berliner Grunewald, mit zwei besonderen Gästen: Publizist Jakob Augstein und Nikolaus Blome, Chef der Politikredaktion von RTL und ntv. Beide streiten sich normalerweise professionell über Politik, unter anderem in ihrem Podcast "Augstein & Blome". Mit Peter sprechen sie über ungewohnte Themen – zum Beispiel Stadtwälder, Bärlauch und Vogelarten. Dabei wird auch so mancher Mythos zum Klimawandel entlarvt.+++Alle Rabattcodes und Infos zu unseren Werbepartnern findet ihr hier: https://linktr.ee/peterundderwald +++Verwende den Code peterundderwald über den folgenden Link, um exklusive 60 % Rabatt auf einen jährlichen Incogni-Plan zu erhalten: https://incogni.com/peterundderwald+++Peter ist auch zu Gast bei "Augstein & Blome" – das hört ihr hier: https://plus.rtl.de/podcast/augstein-blome-ap52kt5apndfv/neue-folge +++ Habt ihr Fragen oder Anmerkungen zu den Themen? Schreibt uns gerne eine E-Mail an podcast@wohllebens-waldakademie.de+++Wenn ihr mehr über den Wald und seine Wunder erfahren wollt, findet ihr in Wohllebens Waldakademie spannende Veranstaltungen & Fortbildungen: www.wohllebens-waldakademie.de +++Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://datenschutz.ad-alliance.de/podcast.html+++ Wir verarbeiten im Zusammenhang mit dem Angebot unserer Podcasts Daten. Wenn Sie der automatischen Übermittlung der Daten widersprechen wollen, klicken Sie hier: https://datenschutz.ad-alliance.de/podcast.html Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit

SummaryIn this episode of the Gird Up podcast, host Charlie Ungemach welcomes Dr. Robert Kolb, a leading scholar on Martin Luther and the Reformation. They discuss Kolb's academic journey, the impact of Luther and Melanchthon on their students, and the relevance of Lutheran theology in today's world. Kolb shares insights into Luther's unique understanding of righteousness, the complexities of Lutheran theology post-Luther, and the importance of Lutheran identity in modern times. The conversation emphasizes the enduring significance of Luther's teachings and their application to contemporary issues of faith and identity. In this conversation, Robert Kolb and Charlie Ungemach explore the profound impact of Luther's theology on personal identity and the church's role in contemporary society. They discuss the importance of understanding oneself as a child of God, the challenges facing the Lutheran Church today, and the significance of the universal priesthood. Kolb shares insights from his experiences in pastoral ministry and emphasizes the need for new pastors to embrace their calling amidst cultural shifts. The dialogue culminates in a call to cling to Christ during difficult times, highlighting the enduring relevance of the gospel.Chapters00:00 Introduction to Gird Up Podcast and Guest Introduction02:51 Dr. Robert Kolb's Academic Journey and Influence07:40 The Impact of Luther and Melanchthon on Their Students11:08 The Complexity of Lutheran Theology Post-Luther16:56 Relevance of Luther's Teachings Today21:32 Luther's Unique Understanding of Righteousness27:11 Luther's Pursuit of Truth and Its Consequences31:11 Key Lessons from the Study of Lutheran Theology38:00 The Importance of Lutheran Identity in Modern Times46:23 The Impact of Luther's Theology49:32 Understanding Our Identity as God's Children52:24 The Role of the Lutheran Church Today55:46 Luther's Influence on Global Christianity01:00:16 Encouragement for New Pastors01:04:51 Challenges Facing the Church01:12:45 The Universal Priesthood01:24:19 Clinging to Christ in Difficult TimesDr. Kolb's Links"Face to Face: Martin Luther's View of Reality" https://www.fortresspress.com/store/product/9781506498324/Face-to-Face"The Christian Faith" https://www.cph.org/christian-faith-ebook-edition"Nikolaus von Amsdorf: Champion of Martin Luther's Reformation" https://www.cph.org/nikolaus-von-amsdorf-champion-of-martin-luthers-reformation"Martin Luther as Prophet, Teacher, and Hero" https://bakerpublishinggroup.com/books/martin-luther-as-prophet-teacher-and-hero/221271Gird Up Links:https://youtube.com/@girdupministries4911?si=tbCa0SOiluVl8UFxhttps://www.instagram.com/girdup_be_a_man/https://www.girdupministries.com Hosted on Acast. See acast.com/privacy for more information.

Bei den Koalitionsverhandlungen geht es in Wahrheit um die Rettung der CDU vor der AfD, kommentiert Nikolaus Blome. Für den Niedergang der Wahlsieger und das weitere Erstarken der AfD macht er auch Merz verantwortlich. Blome, Nikolaus www.deutschlandfunk.de, Kommentare und Themen der Woche

Nützel, Nikolaus www.deutschlandfunkkultur.de, Fazit

Nützel, Nikolaus www.deutschlandfunkkultur.de, Fazit

Thema: Maul- und Klauenseuche in der Slowakei und Ungarn

Die Themen: Geheime Beauty-OP von Wolfgang Kubicki; Klingbeil legte Scholz wohl Verzicht auf Kanzlerkandidatur nahe; Die Causa Friedrich Merz; Landesweite Sabotageserie aus Russland; Trumps Gaza-Pläne; Mossuls Altstadt ist wieder aufgebaut und die Augen-Reportage von Caren Miosga Host der heutigen Folge ist Markus Feldenkirchen (DER SPIEGEL). Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/ApokalypseundFilterkaffee

Nikolaus Correll spoke with us about robots, teaching robotics, and writing books about robots.  Nikolaus is a Professor of Computer Science at the University of Colorado, see his lab website (or his Wikipedia page). We discussed Nikolaus' Introduction to Robotics with Webots Specialization Coursera course (or YouTube Playlist). These go along with his Introduction to Autonomous Robots (which can be compiled from source from github). Masters of Computer Science online via University of Colorado and Georgia Tech. While the Arcbotics Sparki is no longer in production, Nikolaus also mentioned the Amazon Racer. Transcript Nordic Semiconductor has been the driving force for Bluetooth Low Energy MCUs and wireless SoCs since the early 2010s, and they offer solutions for low-power Wi-Fi and global Cellular IoT as well. If you plan on developing robust and battery-operated applications, check out their hardware, software, tools, and services.   On academy.nordicsemi.com, you'll find Bluetooth, Wi-Fi, and cellular IoT courses, and the Nordic DevZone community covers technical questions:  devzone.nordicsemi.com.   Oh, and don't forget to enter Nordic Semiconductor's giveaway contest! Just fill out the entrance form, and you're in the running. Good luck!

What will the world look like in 2030? International business consultant Nikolaus S. Lang predicts the evolution of a multipolar world, with multiple emerging coalitions of countries acting in new ways to achieve their economic, technological and military goals. He dives into what this will mean for the global economy, offering five tips for business leaders to prepare for the coming geopolitical landscape. After the talk, Modupe shares tips on how to train for the unexpected.

What will the world look like in 2030? International business consultant Nikolaus S. Lang predicts the evolution of a multipolar world, with multiple emerging coalitions of countries acting in new ways to achieve their economic, technological and military goals. He dives into what this will mean for the global economy, offering five tips for business leaders to prepare for the coming geopolitical landscape.

What will the world look like in 2030? International business consultant Nikolaus S. Lang predicts the evolution of a multipolar world, with multiple emerging coalitions of countries acting in new ways to achieve their economic, technological and military goals. He dives into what this will mean for the global economy, offering five tips for business leaders to prepare for the coming geopolitical landscape.