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Vom Nikolaus, Christkind und dem Weihnachtsmann – Wer bringt den Kindern im Dezember die Geschenke – der Nikolaus oder der Weihnachtsmann? Warum sind sich die beiden so ähnlich? Und wann kommt das Christkind ins Spiel?
Herzlich willkommen zu Ihrem morgendlichen Newsletter! Tauchen Sie mit uns zum 2. Advent in die faszinierende Geschichte unserer Menschheit ein: Römische Herrscher, hier Marc Aurel, dessen Selbstbetrachtungen nichts an Aktualität und Brisanz eingebüßt haben, die ägyptische Herrscherin Kleopatra, die nicht nur mit Julius Caesar ein Sohn verband, sondern auch drei Kinder vom römischen General Marcus Antonius gebar, und die reichhaltige Geschichte eines Gebäcks zu Ehren des heiligen Nikolaus: der Spekulatius.
In der Frankfurter Traditions-Kabarett-Live-Location „Käs“ laden Hazel und Thomas vor ausverkauftem Haus zum großen Weihnachts-Spezial, sprechen über Gutscheine, Lebkuchen, ungewöhnliche Weihnachts-Mahlzeiten und darüber, wie es ist, sich den Geburtstag mit Jesus zu teilen. 00:00:00 Lustiges Tauchen bei Duell um die Welt 00:07:42 Thomas the Holiday Hoarder & heißer Weihnachtstake: gesunde Plätzchen 00:21:10 Weihnachtsmenü: Pizza, Pferd & Karpfen 00:28:57 20 Minuten Eisbaden & schlimme Weihnachtserinnerungen 00:40:08 Heißer Weihnachtstake: Gutscheine sind keine Geschenke 00:59:03 Heißer Weihnachtstake: Jeder Film ist ein Weihnachtsfilm & Nikolaus nennt Hazel „Esel“ 01:10:02 Wanted: Papp-Hazel Dieb & Aromat-Chips-Tasting 01:19:00 Hazels Ideen: Escort-Service für Meinungen, Stimmungsbarometer-App, schlaffe Klinke 01:29:48 Geburtstag in der Weihnachtszeit 01:36:55 Weihnachtsgeschenkpapier am Geburtstag & eigene Feiertage 01:41:08 Quiz für Juristen & Thomas' Filmempfehlungsbox Zeitstempel können variieren. Hazel bei Duell um die Welt https://www.instagram.com/reel/DRt5QYLDJ-6/?utm_source=ig_web_copy_link&igsh=MzRlODBiNWFlZA== HTH Plätzchen-Tasting https://hazel-thomas-hoererlebnis.podigee.io/116-cookies-akzeptieren-das-grosse-keks-tasting Ist zu viel Protein krebserregend? https://www.chip.de/news/Mediziner-warnen-High-Protein-Trend-kann-das-Krebsrisiko-steigern-sogar-bei-Juengeren_186054818.html Welche Temperatur muss ein Pizzaofen haben? https://www.kuppelofen.de/welche-temperatur-muss-ein-pizzaofen-haben/?srsltid=AfmBOopZLwYdag27Azkm3qVF_8sE7EfEUf9qe4ARL_DccVUtQwuC7FVf Der Weihnachtskarpfen https://www.amazon.de/Weihnachtskarpfen-Rita-Törnqvist-Verschuur/dp/3825179869 Hunde und Katzen essen ist in der Schweiz erlaubt https://www.srf.ch/kultur/gesellschaft-religion/fleischkonsum-in-der-schweiz-warum-essen-wir-nicht-alle-tiere-1 Darmstädter Eiszäpfchen IG https://www.instagram.com/darmstaedter.eiszaepfchen/ Glaubersalz https://www.docmorris.de/ratgeber/magazin/ernaehrung/glaubersalz# Haribo Colorado https://www.haribo.com/de-de/produkte/haribo/color-rado What I know about coffee shops https://www.baristamagazine.com/book-review-what-i-know-about-running-coffee-shops-by-colin-harmon/ Hot Frosty https://www.imdb.com/de/title/tt32359447/?ref_=vp_ov_i Is it cake? https://en.wikipedia.org/wiki/Is_It_Cake%3F Marinierte Tannenzapfen https://www.marmite.ch/rezept/marinoitu-maennynkaepy/ Kraftklub werden bei Kraftklub-Party abgewiesen https://www.mdr.de/nachrichten/thueringen/mitte-thueringen/erfurt/kraftklub-mini-konzert-auf-domplatz-100.html Zweifel Aromat-Chips https://www.zweifel.ch/ch_de/landingpages/zweifelaromat/ Knorrli https://www.knorr.com/ch/de/knorrlis-welt/unser-knorrli.html Costco Nähe Basel https://www.20min.ch/story/mulhouse-f-us-riese-eroeffnet-nahe-der-schweiz-so-sieht-es-im-costco-aus-103453905 Die Käs https://www.diekaes.de Honey-Scam https://youtu.be/vc4yL3YTwWk?si=F44LZPm4gwFBwClO Picklefest https://picklefestcanada.com 31er https://de.wikipedia.org/wiki/31er Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/hoererlebnis Du möchtest Werbung in diesem Podcast schalten? Dann erfahre hier mehr über die Werbemöglichkeiten bei Seven.One Audio: https://www.seven.one/portfolio/sevenone-audio
In dieser aktuellen Ladylike Podcast-Folge geht es ums Dranbleiben: Yvonne und Nicole sprechen über die Kraft der Ausdauer – in der Liebe, im Singleleben und in Beziehungen, die schon viele Jahreszeiten gemeinsam erlebt haben.Nicole lässt tief blicken: vom schmerzhaften Liebeskummer über wilde Erfahrungen im Online-Dating bis hin zur Erkenntnis, dass wahre Liebe bei der Selbstliebe beginnt. Und Yvonne erzählt, warum echte Nähe oft erst nach zehn Jahren entsteht – und wie man auch in Langzeitbeziehungen das Feuer am Lodern hält. Es geht um Geduld, um Kommunikation, um Spaziergänge statt Schweigen und darum, warum man sich nicht von gesellschaftlichen Liebes-Idealen verrückt machen lassen sollte.Gemeinsam sprechen die beiden über Streitkultur, emotionale Reife, Selbstfürsorge und den Druck von außen, ständig „verliebt“ sein zu müssen. Dabei machen sie klar: Liebe ist kein Selbstläufer, sondern ein lebendiges Projekt – manchmal anstrengend, aber immer wieder wunderschön.Diese Folge ist ein liebevoller Reminder für alle, die gerade durch ein Liebestief gehen, frisch verliebt sind oder in einer Langzeitbeziehung neue Impulse suchen: Gebt nicht auf – Liebe lohnt sich!Hört rein in die neue Folge und erfahrt, warum es sich lohnt, Liebe einfach nicht aufzugeben.Habt Ihr selbst erotische Erfahrungen, eine Frage oder Story, über die Yvonne & Nicole im Ladylike-Podcast sprechen sollen? Dann schreibt uns gern an @ladylike.show auf Instagram oder kontaktiert uns über unsere Internetseite ladylike.showHört in die Folgen bei RTL+, iTunes oder Spotify rein und schreibt uns gerne eine Bewertung. Außerdem könnt ihr unseren Podcast unterstützen, indem ihr die neuen Folgen auf Euren Kanälen pusht und Euren Freunden davon erzählt.Lust auf das beste aller Nikolaus- und Weihnachtsgeschenke?! Dann holt Euch das Ladylike-Buch „Da kann ja jede kommen“! Wir wünschen Euch eine kuschlige Zeit! Hier geht's zum Buch: bit.ly/ladylike-buchUnsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.
Da fährt man tief entspannt zum Geburtstag vom besten Kumpel und wird von irgendeinem Beschwerdeführer angepflaumt, weil man den Arsch seine eigenen Perle gut findet. Atze denkt: „Hilf mir dich zu mögen“. Gut, dass er zwei Tage vorher sein großes Idol und Postergirl Desiree Nosbusch mal wieder persönlich getroffen hat. Glückwunsch auch Boris Becker zum fünften Kind! Alle gratulieren, sogar die ehemaligen Knastkumpels aus London. Wenn dann der Nikolaus noch sagt:“ Du darfst mir meine Stiefel lecken!“ist der zweite Advent doch endgültig wieder in Butter.Instagram:https://www.instagram.com/atzeschroeder_offiziell?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw== Hosted on Acast. See acast.com/privacy for more information.
Der 1. Dezember ist da – und mit ihm diese ganz besondere Mischung aus Vorfreude … und Überforderung.Geschenke besorgen, verpacken, verstecken. Weihnachtsfeiern in Kita, Schule und Job. Adventskalender basteln. Plätzchen backen. Adventskranz auftreiben. Haus schmücken, Nikolaus planen, Weihnachtsmarktbesuch irgendwie unterbringen, Familienessen organisieren, Menü überlegen, Anfahrten koordinieren, und nebenbei bitte noch „magische Kindheitserinnerungen“ erschaffen.Alles in einem Monat.Und irgendwo zwischen Wunschzetteln, Terminen und Zimtsternen soll sie stattfinden:die warme, unvergessliche Weihnachtszeit für dein Kind .Doch wie geht es dir eigentlich?Fühlst du dich erschöpft, emotional leer oder einfach nur funktionierend?Fragst du dich, wann genau der Weihnachtszauber abhandengekommen ist –vielleicht ungefähr zu dem Zeitpunkt, als du selbst Mama oder Papa geworden bist?Dann ist diese Folge für dich. In dieser Episode begleitet dich Leandra Vogt, Kindheitspädagogin (M.A.) und Elternberaterin, mit ihrer klaren, liebevollen und fachlich fundierten Art durch den Dezember.Sie hilft dir, zu sortieren, was wirklich wichtig ist –und was du getrost loslassen darfst, ohne dass dein Kind etwas „verpasst“.
Ein tödlicher Fund im Kölner Hilton und ein vermeintlich perfekter Plan. Solltet ihr mich unterstützen wollen oder einfach Interesse daran haben den Fall visuell aufbereitet zu sehen, schaut einfach hier vorbei: https://www.youtube.com/insolitoAnsonsten könnt ihr mich natürlich auch gerne bei Instagram abonnieren: https://www.instagram.com/insolito_yt/Ich wünsche euch einen schönen Morgen, Mittag oder Abend
Die große Schuh-Füll-Challenge ist eröffnet: Passen mehr Nikolaus-Geschenke in einen Stiefel oder in eine Sandale? Und gibt's das irgendwo auf der Welt, dass man Sandalen für den Nikolaus vor die Tür stellt?
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Oscar wartet auf Schnee. Er liebt Schnee. Schnee ist wunderbar weich, glitzert herrlich und vor allem: Schnee ist lecker! Nun ist es Dezember, der Adventskalender halb leer, sogar der Nikolaus war schon da. Aber wer lässt auf sich warten? Der Schnee! Da nimmt Oscar die Sache selbst in die Hand. Ob das hilft? Fällt der Schnee jetzt endlich? Alle 2 Folgen der OHRENBÄR-Hörgeschichte: Papa, wann schneit es? von Lena Hach. Es liest: Matti Krause. ▶ Mehr Hörgeschichten empfohlen ab 4: https://www.ohrenbaer.de/podcast/empfohlen-ab-4.html ▶ Mehr Infos unter https://www.ohrenbaer.de & ohrenbaer@rbb-online.de
Die GamerDaddies – der Podcast rund um das Thema Gaming auf Konsolen und dem PC. Was sie von den anderen Podcasts zum Thema Videospiele unterscheidet, ist, dass sie alles aus dem Blickwinkel von Vätern für Väter betrachten. Gerit, Buddha und Flo analysieren, ob Computerspiele familientauglich sind und sprechen darüber, wie man am besten Familie, Kinder, Gaming und andere Hobbies unter einen Hut bekommt. Diesmal geht es um das Thema: Warum feiern wir Nikolaus? Gezockt haben die beiden Daddies natürlich auch und zwar auf der Retrawave. Spotify: https://spoti.fi/32so0js Apple: https://apple.co/2NPCEvP www.gamerdaddies.de HOLY Energy: https://de.weareholy.com/discount/GEZOCKT?ref=geritzockt CODE: Gezockt (10 Prozent Rabatt) Partner: www.perfekt-zocken.de Twitch: www.twitch.tv/GeritZockt https://www.twitch.tv/desman2k6 Discord: https://discord.gg/YaSrPYjbUg
Die GamerDaddies – der Podcast rund um das Thema Gaming auf Konsolen und dem PC. Was sie von den anderen Podcasts zum Thema Videospiele unterscheidet, ist, dass sie alles aus dem Blickwinkel von Vätern für Väter betrachten. Gerit, Buddha und Flo analysieren, ob Computerspiele familientauglich sind und sprechen darüber, wie man am besten Familie, Kinder, Gaming und andere Hobbies unter einen Hut bekommt. Diesmal geht es um das Thema: Warum feiern wir Nikolaus? Gezockt haben die beiden Daddies natürlich auch und zwar auf der Retrawave. Spotify: https://spoti.fi/32so0js Apple: https://apple.co/2NPCEvP www.gamerdaddies.de HOLY Energy: https://de.weareholy.com/discount/GEZOCKT?ref=geritzockt CODE: Gezockt (10 Prozent Rabatt) Partner: www.perfekt-zocken.de Twitch: www.twitch.tv/GeritZockt https://www.twitch.tv/desman2k6 Discord: https://discord.gg/YaSrPYjbUg
Psychisch Kranke wurden lange in großen Anstalten untergebracht. Doch 1975 zeigte ein Bericht der Bundesregierung, wie schlecht ihre Versorgung war. Er leitete eine Wende ein: weg von Verwahrung, hin zu Betreuung – mit spürbaren Folgen bis heute. Nützel, Nikolaus www.deutschlandfunk.de, Kalenderblatt
In dieser Folge starten wir direkt mit einer überraschend ehrlichen Frage: Scheuert es eigentlich, wenn man nichts drunter trägt? Während Jana eindeutig „Ja!“ sagt, sieht Ramon das eher entspannt. Von dort geht's nahtlos weiter zu einem Thema, das uns alle irgendwann trifft: Ab wann hat man sich an seinen Möbeln sattgesehen? Und wann ist es wirklich Zeit für etwas Neues? Danach drehen wir voll auf im Nostalgie-Modus: die D-Mark! Wie viel davon noch im Umlauf ist, wie viele Münzen und Scheine tatsächlich existieren, wo man heute noch damit bezahlen kann – und wie der aktuelle Umtauschkurs aussieht. Die Zahlen überraschen uns selbst. Außerdem stellen wir Jana auf die Probe: Wie gut ist ihr Hauptstadtwissen wirklich? Spoiler: Besser als erwartet. Zum Finale wird es richtig praktisch: Wir sammeln für euch Nikolausgeschenk-Ideen unter 15 Euro, die nicht nach „Verlegenheitsgeschenk“ aussehen. Von kleinen Beauty-Überraschungen über Alltagshelfer bis zu witzigen Mini-Gadgets – wir überlegen, was wirklich Freude macht, ohne das Budget zu sprengen. Und dann entfachen wir noch eine kleine Grundsatzdebatte: Können günstige Parfums gut riechen – oder riecht billig auch immer billig? Wir reden darüber, was preiswerte Düfte heute wirklich können, und warum manche High-End-Düfte ihr Geld wert sind, oder vielleicht auch nicht?
Blome, Nikolaus www.deutschlandfunk.de, Kommentare und Themen der Woche
Die Themen: Frischer Atem dank Knoblauch-Mundwasser; Mamdani trifft Trump; Protest gegen Merz-Rede zu Integration; Die schwarz-rote Koalition als „letzte Kugel der Demokratie“; Christian Lindner zieht Bilanz; Paul McCartney will nicht durch einen Computer ersetzt werden und warum heiraten Menschen nicht? Host der heutigen Folge ist Yasmine M'Barek (Zeit Online) Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/ApokalypseundFilterkaffee
Elfriede GaengLe avventure di Olimpia e del riccio Fritz 2Carabba Editore, LancianoSe nella prima storia l'autrice ha affrontato con successo il delicato tema del bullismo, in questa seconda avventura a fare da sottofondo sono la diversità e la discriminazione. Argomenti altrettanto rilevanti.Stavolta Olimpia e il riccio Fritz decidono di esplorare la magnifica Villa rinascimentale che si trova tra il giardino all'italiana e il labirinto. Da Bernardo e Gottardo, i due orsetti di bosso, vengono a sapere che lì vive Arlo, il figlio di Nikolaus, con la moglie Margherita e due figli, Astro e Stella. I quattro passeri e Rosso, lo scoiattolo, aggiungono altre informazioni. È in atto un incantesimo all'interno della Villa. L'elfo Grigio, il consigliere di Oscuro, che in cambio di un sontuoso pranzo a settimana protegge la famiglia di Arlo dagli elfi neri, ha fermato il tempo. Gullit, il figlio della fata Smeraldina, un folletto simpatico, intelligente, ma molto permaloso, ne è involontariamente la causa... Tra furti, incantesimi, specchi magici, dolci succulenti, cioccolata portentosa, scontri di ogni genere e saggi maghi, succederà di tutto.Ma sarà la Regina Amber a fare la differenza, deciderà che la festa per la liberazione della Villa si terrà solo dopo la scelta che avrà maturato l'elfo Grigio. Scelta che si rivelerà molto coraggiosa e sorprenderà tutti.Rimarrà come è nato: Grigio, diverso da tutti gli altri elfi; non amando né i Bianchi, certi di essere sempre nel giusto, né i Neri per svariate altre ragioni. Non bisogna mai cambiare se stessi per piacere agli altri. Solo restando Grigio sarà in grado di capire le ragioni degli uni e degli altri.Amber apprezzerà il suo coraggio e lo nominerà giudice del regno. Olimpia e il riccio Fritz, proclamati eroi del bosco, capiranno quanto sia importante scegliere nella vita e come la diversità sia un valore e vada accettata in quanto tale. Elfride Gaeng vive e lavora a Roma, regista e sceneggiatrice per il cinema e la fiction Tv. Ha diretto il lungometraggio “Blu elettrico”, protagonista Claudia Cardinale. Ha prodotto e diretto numerosi documentari per Rai3. Ha scritto diversi romanzi e raccolte di racconti, tra cui “Buchi di vuoto” (2003), “Derma blu” (2005) e “Con il sole negli occhi” (2013), “Le voci elettriche cantano intorno” (2023). Fa il suo esordio nella narrativa per bambini nel 2024 con “Le avventure di Olimpia e il riccio Fritz”.Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/il-posto-delle-parole--1487855/support.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/
Medien funktionieren heute anders als früher und politische Formate müssen sich darauf einstellen. Im zweiten Teil des Gesprächs mit Nikolaus Blome spricht Christian Jakubetz über die Zukunft des politischen Journalismus: Welche Rolle spielen lineares Fernsehen, Social Media und neue Talkshows? Wie verändern Influencer, parteigebundene Kanäle und YouTube die öffentliche Debatte? Blome spricht in diesem Teil auch über seine journalistischen Stationen und über Karrierewege heute.
Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit
Gemeinsam mit Prof. Dr. Thomas Beyerle (Immo Insider Podcast) spreche ich mit Nikolaus Thomale, Gründer von MYNE Homes.Was macht MYNE Homes?MYNE Homes bringt kleine Gruppen zusammen, die Luxus-Ferienimmobilien gemeinsam besitzen, nutzen und die Kosten teilen.Im Gespräch geht's um:• das Geschäftsmodell Co-Ownership• das „Bond-Haus“ (James-Bond-Villa in Schweden)• typische Fehler & Learnings aus dem Aufbau• Immobilienmärkte, Regulierung & Nachfrage• Zielgruppen, Nutzung, Prozesse & Zukunftspläne• persönliche Storys von Nikolaus – von Rügen bis MallorcaAußerdem gibt's ein Weihnachts-Special:MYNE übernimmt bis zu 1.000 € deiner Reisekosten, wenn du eine Immobilie besichtigst und dich auf die Podcastfolge berufst.Links:LinkedIn Nikolaus: https://de.linkedin.com/in/nikolausthomaleLinkedIn Thomas: https://de.linkedin.com/in/prof-dr-thomas-beyerle-42670112LinkedIn Wolfgang: https://www.linkedin.com/in/wolfgang-patz/Webseite MYNE Homes: https://www.myne-homes.com/dePodcast-Agentur: https://nextgen-podcast.de/Immo Insider Podcast: https://immo-insider.podigee.io/Kapitel:00:00 Einstieg & Bond-Haus00:38 Vorstellung Unternehmer-Podcast + Immo Insider01:06 Wer ist Nikolaus Thomale?01:30 Was macht MYNE Homes genau?02:12 Warum wollen so viele ein Ferienhaus – aber kaufen keins?03:39 Das Problem: Kosten, Leerstand, Aufwand04:00 Persönlicher Einstieg & 1. Immobilie auf Rügen05:00 Wie das Geschäftsmodell entstand06:16 Marktgröße (4,9 Billionen € in Europa)07:05 Fragmentierung & Chance für Co-Ownership08:44 Wie MYNE Immobilien auswählt09:46 Alte Welt vs. neue Welt (Timeshare vs. Co-Ownership)11:20 Luxus, Preise & „The Bond“ Villa14:22 Einrichtung, Qualität & Premium-Anspruch15:47 Lage, Lage, Lage – + Infrastruktur & Legal Checks18:07 Regulierung, Leerstand & Massentourismus20:34 Nutzung, Zielgruppen & App-Reservierungen25:22 Vermietung vs. reine Eigennutzung26:53 Kaufprozess, virtuell & live27:50 Eigentumsprozess, Unterlagen & 14-Tage-Widerruf33:23 Tiefschläge, Krisen & Learnings35:54 Asset-Light-Modell, Co-Buyer, Finanzierung37:27 Was gut funktioniert hat38:57 Owner-Netzwerk, Tausch, Zufriedenheitsgarantie40:11 Wo macht Nikolaus selbst Urlaub?41:11 Empfehlung für nächsten Podcast-Gast41:52 Weihnachtsaktion: 1.000 € ReisekostenKeywords:Co-Ownership, MYNE Homes, Ferienhaus kaufen, Luxusimmobilien, James Bond Villa, Immobilie teilen, Unternehmer Podcast, Immo Insider, Ferienhaus Mallorca, Immobilieninvestments, Zweitwohnsitz, Rügen Prora, Mallorca Finca, Ferienimmobilien Markt, Immobilien Trends Europa
Die Themen: „Furzgrundel“-Fisch kehrt zurück nach Bayern; Rentenstreit in der Union; Polizisten schießen auf gehörlose Zwölfjährige; Kein Recht auf veganes Essen im bayrischen Gefängnis; Zahl der Wohnungslosen steigt auf über eine Million; Die Sexting-Affäre von Robert F. Kennedy Jr. und Glühwein im Wandel Hosts der heutigen Folge sind Markus Feldenkirchen (DER SPIEGEL) und Yasmine M'Barek (Zeit Online) Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/ApokalypseundFilterkaffee
„Was wir weniger können als früher, ist einander zuhören – oder uns von guten Argumenten der Gegenseite beeindrucken lassen.“ Mit dieser Beobachtung beschreibt Nikolaus Blome, Ressortleiter Politik und Gesellschaft in der Zentralredaktion der Mediengruppe RTL Deutschland sowie Online-Kolumnist beim SPIEGEL, den Zustand unserer Debattenkultur. In dieser Episode spricht er – im ersten Teil eines zweiteiligen Gesprächs – mit Gastgeber Christian Jakubetz darüber, wie sich politischer Streit und das Verständnis von „konservativ“ in den vergangenen Jahren verschoben haben. Blome erklärt, wie sehr traditionelle politische Zuordnungen bröckeln, weshalb Vertrauen in Medien fragiler geworden ist und wie soziale Netzwerke Konflikte zuspitzen. Er ordnet ein, wie wichtig es ist, dass sich Menschen mit ihren Ansichten in den Medien wiederfinden, warum alte Gewissheiten immer weniger tragen und weshalb Medien neu lernen müssen, gesellschaftliche Stimmungen realistischer abzubilden.
Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit
In dieser Podcastfolge nimmt Zarah ihre Hörer mit auf eine Reise durch den Schwarzwald von Süd nach Nord zu kleinen, unbekannteren Weihnachtsmärkten. Ihre Tour beginnt in Furtwangen. Dort besucht sie den Barbaramarkt. Diesen Krämermarkt gibt es bereits seit dem Jahr 1636. Danach fährt Zarah weiter in die idyllische Fachwerkstadt Gengenbach. Highlight dort ist, neben dem Adventsmarkt, das weltgrößte Adventskalenderhaus. Einen Katzensprung weiter liegt Sasbachwalden. Die Köstlichkeiten auf dem dortigen Weihnachtsmarkt sind etwas ganz besonderes - sie sind nämlich alle glutenfrei. Weiter geht die Reise nach Bad Herrenalb. Auf diesem Weihnachtsmarkt sorgt die Beleuchtung des Flusses Alb für romantische Stimmung. Wer außergewöhnlich nach Bad Herrenalb anreisen möchte, kann dies mit einem echten Dampfzug machen inklusive des Nikolaus als Passagier. Neben diesen Weihnachtsmärkten besucht sie auch den in Ottenhöfen, die Bärenweihnacht in Bad Rippoldsau-Schappbach und den im elsässischen Strasbourg. Freut euch auf eine informative Episode mit vielen Neuigkeiten aus dem Schwarzwald. Seid gespannt!
It is common to define Europe by its democratic, scientific, religious, and cultural traditions. But in What is European? On Overcoming Colonial and Romantic Modes of Thought (Amsterdam UP, 2025), Dag Nikolaus Hasse argues that the search for Europe's essence has taken a troubling turn. He shows that many traditional ideas about Europe are culturally one-sided and historically and geographically distorted, and calls for a decolonisation and deromanticisation of the discourse on Europe. The book promotes an inclusive vision of Europe that reflects its long history of multiethnic cities, offers a cultural home to a wider range of people across the continent, and extends attention and respect to other continents, thus laying a more respectful foundation for shaping the future together.At the same time, Hasse demonstrates that overcoming colonial ways of thinking does not and should not result in anti-Europeanism. Criticising European arrogance may well go hand in hand with feeling culturally at home in other traditions of Europe. For this, it does not matter whether one is a resident of the European continent or not. There is no privileged access to European culture or to the culture of any other continent. Dag Nikolaus Hasse is professor of the history of philosophy at the University of Würzburg. Among his numerous publications, two monographs stand out: Avicenna's De Anima in the Latin West (2000), and Success and Suppression: Arabic Sciences and Philosophy in the Renaissance (2016). In 2016, Hasse was awarded the prestigious Gottfried Wilhelm Leibniz Prize, the highest disctinction for a scientist in Germany. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube Channel: here Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
It is common to define Europe by its democratic, scientific, religious, and cultural traditions. But in What is European? On Overcoming Colonial and Romantic Modes of Thought (Amsterdam UP, 2025), Dag Nikolaus Hasse argues that the search for Europe's essence has taken a troubling turn. He shows that many traditional ideas about Europe are culturally one-sided and historically and geographically distorted, and calls for a decolonisation and deromanticisation of the discourse on Europe. The book promotes an inclusive vision of Europe that reflects its long history of multiethnic cities, offers a cultural home to a wider range of people across the continent, and extends attention and respect to other continents, thus laying a more respectful foundation for shaping the future together.At the same time, Hasse demonstrates that overcoming colonial ways of thinking does not and should not result in anti-Europeanism. Criticising European arrogance may well go hand in hand with feeling culturally at home in other traditions of Europe. For this, it does not matter whether one is a resident of the European continent or not. There is no privileged access to European culture or to the culture of any other continent. Dag Nikolaus Hasse is professor of the history of philosophy at the University of Würzburg. Among his numerous publications, two monographs stand out: Avicenna's De Anima in the Latin West (2000), and Success and Suppression: Arabic Sciences and Philosophy in the Renaissance (2016). In 2016, Hasse was awarded the prestigious Gottfried Wilhelm Leibniz Prize, the highest disctinction for a scientist in Germany. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube Channel: here Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/critical-theory
It is common to define Europe by its democratic, scientific, religious, and cultural traditions. But in What is European? On Overcoming Colonial and Romantic Modes of Thought (Amsterdam UP, 2025), Dag Nikolaus Hasse argues that the search for Europe's essence has taken a troubling turn. He shows that many traditional ideas about Europe are culturally one-sided and historically and geographically distorted, and calls for a decolonisation and deromanticisation of the discourse on Europe. The book promotes an inclusive vision of Europe that reflects its long history of multiethnic cities, offers a cultural home to a wider range of people across the continent, and extends attention and respect to other continents, thus laying a more respectful foundation for shaping the future together.At the same time, Hasse demonstrates that overcoming colonial ways of thinking does not and should not result in anti-Europeanism. Criticising European arrogance may well go hand in hand with feeling culturally at home in other traditions of Europe. For this, it does not matter whether one is a resident of the European continent or not. There is no privileged access to European culture or to the culture of any other continent. Dag Nikolaus Hasse is professor of the history of philosophy at the University of Würzburg. Among his numerous publications, two monographs stand out: Avicenna's De Anima in the Latin West (2000), and Success and Suppression: Arabic Sciences and Philosophy in the Renaissance (2016). In 2016, Hasse was awarded the prestigious Gottfried Wilhelm Leibniz Prize, the highest disctinction for a scientist in Germany. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube Channel: here Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/intellectual-history
It is common to define Europe by its democratic, scientific, religious, and cultural traditions. But in What is European? On Overcoming Colonial and Romantic Modes of Thought (Amsterdam UP, 2025), Dag Nikolaus Hasse argues that the search for Europe's essence has taken a troubling turn. He shows that many traditional ideas about Europe are culturally one-sided and historically and geographically distorted, and calls for a decolonisation and deromanticisation of the discourse on Europe. The book promotes an inclusive vision of Europe that reflects its long history of multiethnic cities, offers a cultural home to a wider range of people across the continent, and extends attention and respect to other continents, thus laying a more respectful foundation for shaping the future together.At the same time, Hasse demonstrates that overcoming colonial ways of thinking does not and should not result in anti-Europeanism. Criticising European arrogance may well go hand in hand with feeling culturally at home in other traditions of Europe. For this, it does not matter whether one is a resident of the European continent or not. There is no privileged access to European culture or to the culture of any other continent. Dag Nikolaus Hasse is professor of the history of philosophy at the University of Würzburg. Among his numerous publications, two monographs stand out: Avicenna's De Anima in the Latin West (2000), and Success and Suppression: Arabic Sciences and Philosophy in the Renaissance (2016). In 2016, Hasse was awarded the prestigious Gottfried Wilhelm Leibniz Prize, the highest disctinction for a scientist in Germany. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube Channel: here Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/european-studies
Bernau, Nikolaus www.deutschlandfunk.de, Kultur heute
It is common to define Europe by its democratic, scientific, religious, and cultural traditions. But in What is European? On Overcoming Colonial and Romantic Modes of Thought (Amsterdam UP, 2025), Dag Nikolaus Hasse argues that the search for Europe's essence has taken a troubling turn. He shows that many traditional ideas about Europe are culturally one-sided and historically and geographically distorted, and calls for a decolonisation and deromanticisation of the discourse on Europe. The book promotes an inclusive vision of Europe that reflects its long history of multiethnic cities, offers a cultural home to a wider range of people across the continent, and extends attention and respect to other continents, thus laying a more respectful foundation for shaping the future together.At the same time, Hasse demonstrates that overcoming colonial ways of thinking does not and should not result in anti-Europeanism. Criticising European arrogance may well go hand in hand with feeling culturally at home in other traditions of Europe. For this, it does not matter whether one is a resident of the European continent or not. There is no privileged access to European culture or to the culture of any other continent. Dag Nikolaus Hasse is professor of the history of philosophy at the University of Würzburg. Among his numerous publications, two monographs stand out: Avicenna's De Anima in the Latin West (2000), and Success and Suppression: Arabic Sciences and Philosophy in the Renaissance (2016). In 2016, Hasse was awarded the prestigious Gottfried Wilhelm Leibniz Prize, the highest disctinction for a scientist in Germany. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube Channel: here Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/british-studies
In der Entscheidung 4 Ob 78/25m hat sich der OGH damit beschäftigt, was zu geschehen hat, wenn ein Bauwerk Mängel aufweist und die Gewährleistungsfrist schon abgelaufen ist. Die Details dieser Entscheidung erläutern Dr. Nikolaus Weselik, Partner bei der Kanzlei CMS und Sonja Rabenseifner vom Linde Verlag.
Nützel. Nikolaus www.deutschlandfunk.de, Andruck - Das Magazin für Politische Literatur
Und schon haben wir die Brücke zum Geld – Ulrike ist unsere Geldexpertin. Ulrike, dein Thema: Geld. Warum ist Geld wichtig? Geld ist genauso wichtig wie Gesundheit. Wir dürfen Verantwortung übernehmen und uns dem Thema stellen. Denn wenn wir es nicht tun, ist es ganz schnell weg. Wir wollen mehr daraus machen, und darauf habe ich mich spezialisiert – das gebe ich gerne weiter. Super! Also: Geld ist Chefsache. Beschäftigt euch damit – dann wird's wunderschön. Milena, dein Thema: Gesundheit. Nur wer gesund ist, kann auch Geld verdienen und ein schönes Leben führen. Wenn du nicht gesund bist, kommst du nicht weit. Also: Beschäftigt euch um eure Gesundheit, bleibt fit und genießt euer Leben! Milena kommt immer dann zum Einsatz, wenn gar nichts mehr geht – sie hat ein riesiges Repertoire. Ivonne, du machst nicht nur Patientenverfügung, sondern rettest Frauen – vor wem? Eigentlich vor sich selbst. Viele Frauen leben nach dem Glaubenssatz: „Ich muss das machen. Wie sieht es aus, wenn ich es nicht mache?" Sie sind Mutter, Partnerin, Taxi, Berufstätige – aber nie sie selbst. In unseren Seminaren finden wir heraus, wie du deine Hauptrolle im Leben wieder einnimmst. Denn: Geld und Gesundheit sind wertlos, wenn du dich selbst aufgibst. Wir sind die drei Gs – Geld, Gesundheit, Glück. Immer im Dreiklang miteinander verbunden. Wenn du dich verloren hast – finde dich wieder und werde die Hauptrolle deines Lebens. Ulrike ist eine echte Rallyefahrerin – vom ersten direkt in den fünften Gang! Auf der Bühne: Vollgas, Power, Rampensau. Da bleibt kein Auge trocken! In St. Moritz hat es geschneit, jetzt scheint wieder die Sonne – perfekt zum Baden! Noch eine Runde Vitamin D tanken. Indian Summer – die Wälder leuchten, die Natur ist ein Traum. Im November wird die weiße Pracht Einzug halten – Faszination pur! St. Moritz ist ein echter Kraftort. Ulrike: „Das Farbenspiel ist traumhaft. Meine künstlerische Ader kommt da richtig durch. So viel Inspiration, so viel Freiheit – einfach ein Wohlfühlort." Darum geht's: Wo hast du deine Kraftorte? Wo findest du Inspiration? Im November kannst du in Bad Dürkheim dabei sein – beim Seminar von Ivonne, Ulrike oder mir. Du bist herzlich eingeladen! Du übernimmst nur die Hotelübernachtung, alles andere ist unser Geschenk. Ende des Monats sind wir wieder in St. Moritz, und vom 5. bis 7. Dezember findet unsere Mastermind über Nikolaus statt – mit hochkarätigen Menschen. Wenn du sagst: „Wow, das interessiert mich!", schreib mir einfach. Die Teilnahme ist exklusiv – nur für geladene Gäste, damit die Gruppe homogen bleibt und jeder einen echten Mehrwert hat. Und dann – das Palace Hotel! Wenn abends die Lichter angehen, ist es magisch. Ulrike: „Fast wie Walt Disney, aber echt! Alles leuchtet, geschmückt – St. Moritz ist ein Lichtermeer." Ivonne: „Stell dir vor, du sitzt auf der Couch, schaust Drei Nüsse für Aschenbrödel, isst Plätzchen, Kerzen brennen – dieses Gefühl hast du hier dauerhaft. Du kommst nicht mehr raus aus dieser schönen Stimmung. Alles strahlt dieses Gefühl aus." Einfach wunderschön – Romantik pur! Jetzt sind wir angekommen – ab ins Wasser! Und schaut mal runter: Das ganze Bad nur für uns, Sonne, Bergkulisse – einfach der Hammer! In diesem Sinne: Einen wunderschönen Sonntagnachmittag – genießt euer Leben!
Geyrhalter, Nikolaus www.deutschlandfunkkultur.de, Vollbild
Bernau, Nikolaus www.deutschlandfunkkultur.de, Studio 9
Die Erde steht nicht still, sie kreist um die Sonne! Nikolaus Kopernikus löst alte Probleme der Astronomie durch eine neue Sicht auf die Bewegungen der Himmelskörper. Doch nicht alle Ungereimtheiten sind nun überwunden. Warum zum Beispiel fällt ein Stein senkrecht nach unten, wenn er fällt? Wenn die Erde sich dreht, müsste er dann nicht seitlich fallen? Die "Kopernikanische Revolution" war erst der Beginn der großen Wende im Verständnis der Welt und ihres Orts im Universum.
Bernau, Nikolaus www.deutschlandfunk.de, Kultur heute
Nikolaus Thomale, Gründer von MYNE Homes, spricht über den Aufbau einer effektiven Feedback-Kultur. Er teilt, wie sie mit OKRs und Steering Boards arbeiten, warum All-Hands-Meetings monatlich stattfinden und wie sie eine sehr niedrige Mitarbeiterfluktuation erreichen. Was du lernst: Wie du Management-Meetings effektiv strukturierst Die richtige Balance im Feedback-Prozess Warum Transparenz entscheidend ist Den richtigen Mix aus Kontrolle und Entwicklung finden ALLES ZU UNICORN BAKERY: https://stan.store/fabiantausch Mehr zu Nikolaus: LinkedIn: https://www.linkedin.com/in/nikolausthomale/ MYNE Homes: https://www.myne-homes.com/de Join our Founder Tactics Newsletter: 2x die Woche bekommst du die Taktiken der besten Gründer der Welt direkt ins Postfach:https://www.tactics.unicornbakery.de/
Der Wohnungsmarkt in deutschen Großstädten ist stark angespannt. Das hat weitreichende soziale Folgen und führt zu Unzufriedenheit. Was sind die Ursachen dieser Misere? Welche Lösungen kann es geben? Bernau, Nikolaus; Rink, Dieter www.deutschlandfunkkultur.de, Im Gespräch
Deutschlands Wirtschaft schwächelt und Atze macht sich große Sorgen um den 6.Advent. Die Firma, die uns immer die billigen Nikoläuse in die Baumärkte gestellt hat, ist insolvent. Außerdem war unser Lieblingskomiker endlich mal wieder im Kino und ist entsetzt darüber, wieviel ein normaler Mensch an Nachos, Popcorn und Cola in sich reinstopfen kann. Gott sei Dank ist wenigstens Jack White mit seinen 85Jahren wieder Single und auf dem Markt. Elitepartner und golden Bachelor reiben sich die Hände. Kopfschüttelnd stellt man fest: Wat ne Woche!Instagram:https://www.instagram.com/atzeschroeder_offiziell/?hl=de Hosted on Acast. See acast.com/privacy for more information.
Bernau, Nikolaus www.deutschlandfunkkultur.de, Studio 9
We sit down with filmmaker Nikolaus Aldrich to talk about their short film The Visitor To watch footage from the discussion, visit our YouTube channel https://www.youtube.com/@BTAABM2 and visit https://thepfpn.com/ for more great content
Wie finden Patienten das richtige Krankenhaus? Nicht nur das Gesundheitsministerium, auch Verlage wollen mit Rankings und Siegeln Orientierung bieten. Doch die Kriterien sind oft unklar und teils wahllose Bewertungen beeinflussen den Wettbewerb. Nützel, Nikolaus www.deutschlandfunk.de, Hintergrund
Frenzel, Korbinian www.deutschlandfunkkultur.de, Studio 9 - Der Tag mit ...
Nützel, Nikolaus www.deutschlandfunk.de, Tag für Tag
Bernau, Nikolaus www.deutschlandfunkkultur.de, Fazit
Progressive supranuclear palsy and corticobasal syndrome are closely related neurodegenerative disorders that present with progressive parkinsonism and multiple other features that overlap clinically and neuropathologically. Early recognition is critical to provide appropriate treatment and supportive care. In this episode, Teshamae Monteith, MD, FAAN speaks with Nikolaus R. McFarland, MD, PhD, FAAN, author of the article “Progressive Supranuclear Palsy and Corticobasal Syndrome” in the Continuum® August 2025 Movement Disorders issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. McFarland is an associate professor of neurology at the University of Florida College of Medicine at the Norman Fixel Institute for Neurological Diseases in Gainesville, Florida. Additional Resources Read the article: Progressive Supranuclear Palsy and Corticobasal Syndrome Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Monteith: Hi, this is Dr Teshamae Monteith. Today I'm interviewing Dr Nikolaus McFarland about his article on progressive supranuclear palsy and cortical basilar syndrome, which appears in the August 2025 Continuum issue on movement disorders. Welcome, how are you? Dr Farland: I'm great. Thank you for inviting me to do this. This is a great opportunity. I had fun putting this article together, and it's part of my passion. Dr Monteith: Yes, I know that. You sit on the board with me in the Florida Society of Neurology and I've seen your lectures. You're very passionate about this. And so why don't you first start off with introducing yourself, and then tell us just a little bit about what got you interested in this field. Dr Farland: I'm Dr Nicholas McFarlane. I'm an associate professor at the University of Florida, and I work at the Norman Fixel Institute for Neurological Diseases. I am a director of a number of different centers. So, I actually direct the cure PSP Center of Care and the MSA Center of Excellence at the University of Florida; I also direct the Huntington's clinic there as well. But for many years my focus has been on atypical parkinsonisms. And, you know, I've treated these patients for years, and one of my focuses is actually these patients who suffer from progressive supranuclear palsy and corticobasal syndrome. So that's kind of what this review is all about. Dr Monteith: You probably were born excited, but I want to know what got you interested in this in particular? Dr Farland: So, what got me interested in this in particular was really the disease and the challenges that's involved in it. So, Parkinson's disease is pretty common, and we see a lot of that in our clinic. Yet many times, roughly about 10 to 15% of my patients present with these atypical disorders. And they're quite fascinating. They present in different ways. They're fairly uncommon. They're complex disorders that progress fairly rapidly, and they have multiple different features. They're sort of exciting to see clinically as a neurologist. I think they're really interesting from an academic standpoint, but also in the standpoint of really trying to bring together sort of a team. We have built a multidisciplinary team here at the University of Florida to take care of these patients. They require a number of folks on that team to take care of them. And so, what's exciting, really, is the challenge of treating these patients. There are very limited numbers of therapies that are available, and the current therapies that we have often really aren't great and over time they fail. And so, part of the challenge is actually doing research. And so, there's actually a lot of new research that's been going on in this field. Recently, there's been some revisions to the clinical criteria to help diagnose these disorders. So, that's really what's exciting. The field is really moving forward fairly rapidly with a number of new diagnostics, therapeutics coming out. And hopefully we can make a real difference for these patients. And so that's what really got me into this field, the challenge of trying to treat these patients, help them, advocate for them and make them better. Dr Monteith: And so, tell me what the essential points of this article. Dr Farland: So, the essential points, really, of this article is: number one, you know, just to recognize the new clinical criteria for both PSP and corticobasal syndrome, the diagnosis for these disorders or the phenotypic spectrum has really expanded over the years. So, we now recognize many different phenotypes of these disorders, and the diagnosis has gotten fairly complicated. And so, one of the goals of this article was to review those new diagnostic criteria and the different phenotypic ways these diseases present. I wanted to discuss, also, some of the neuropathology and clinicopathological overlap that's occurred in these diseases as well as some of the new diagnostic tests that are available. That's definitely growing. Some of the new studies that are out, in terms of research and clinical trials. And then wanted to review some of the approaches for treatment for neurologists. Particularly, we're hoping that, you know, this article educates folks. If you're a general neurologist, we're hoping that recognizing these diseases early on will prompt you to refer these patients to specialty clinics or movement disorder specialists early on so they can get appropriate care, confirm your diagnosis, as well as get them involved in trials if they are available. Dr Monteith: And how has the clinical criteria for PSP and cortical basilar syndrome changed? Dr Farland: I think I already mentioned there's been an evolution of the clinical criteria for PSP. There's new diagnostic criteria that were recently published, and it recognizes the multiple clinical phenotypes and the spectrum of the disease that's out there, which is much broader than we thought about. Corticobasal clinical criteria are the Dr Armstrong criteria from 2013. They have not been updated, but they are in the works of being updated. But it does recognize the classic presentation of corticobasal syndrome, plus a frontal executive predominant and then a variant that actually overlaps with PSP. So, there's a lot more overlap in these two diseases than we originally recognized. Dr Monteith: And so, you spoke a bit about FTD spectrum. So why don't you tell us a little bit about what that is? I know you mentioned multiple phenotypes. Dr Farland: What I really want to say is that both PSP and corticobasal syndrome, they're relatively rare, and what- sort of as to common features, they both are progressive Parkinson disorders, but they have variable features. While they're commonly associated with Parkinson's, they also fit within this frontotemporal lobar spectrum, having features that overlap both clinically and neuropathologically. I just want folks to understand that overlap. One of this pathological overlap here is the predominant Tau pathology in the brain, an increasing recognology- recognition of sort of the pathological heterogeneity within these disorders. So, there's an initial description, a classic of PSP, as Richardson syndrome. But now we recognize there are lots of different features to it and there are different ways it presents, and there's definitely a lot of clinical pathological overlap. Dr Monteith: Why don't we just talk about some red flags for PSP? Dr Farland: Yeah, sure. So, some of the red flags for PSP and even corticobasal syndrome are: number one is rapid progression with early onset of falls, gait difficulty, falling typically backwards, early speech and swallow problems that are more prominent than you see in Parkinson's disease, as well as eye gaze issues. So, ocular motor features, particularly vertical gaze palsy. In particular what we talk about is the supranuclear gaze palsy, and one of the most sensitive features that we've seen with these is downgaze limitation or slowed downgaze, and eventually a full vertical gaze palsy and followed supranuclear gaze palsy. So, there's some of the red flags that we see. So, while we think about the lack of response to levodopa frequently as something that's a red flag for Parkinson's, there are many times that we see Parkinson's patients, and about a quarter of them don't really respond. There's some features that don't respond to levodopa that may not be so specific, but also can be helpful in this disease. Dr Monteith: And what about the red flags for cortical basilar syndrome? Dr Farland: So, for cortical basilar syndrome, some of the red flags again are this rapidly depressive syndrome tends to be, at least in its classical present presentation, more asymmetric in its presentation of parkinsonism, with features including things like dystonic features, okay? For limb dystonia and apraxias---so, inability to do a learned behavior. One of those red flags is a patient who comes in and says, my hand doesn't work anymore, which is something extremely uncommon that you hear in Parkinson's disease. Most of those patients will present, say, I might have a tremor, but they very rarely will tell you that I can't use my hand. So look out for that sign. Dr Monteith: And let's talk a little bit about some of the advances in the fields you mentioned, evolving biomarker and imaging capacities. So, how are these advances useful in helping us understand these conditions, especially when there's so much heterogeneity? Dr Farland: I might start by talking a little bit about some of the clinical criteria that have advanced. Why don't we start there and just discuss some of the advances? I think in PSP, I think, originally we had both probable and possible diagnoses of PSP, and the diagnostic criteria were basically focused on what was what's called “classical PSP” or “Richardson syndrome”. But now we recognize that there are multiple phenotypes. There's an overlap with Parkinsonism that's slower in progression and morphs into PSP, the classical form. There's a frontal behavioral variant where patients present with that frontal behavioral kind of thing. There's a speech-language variant that can overlap with PSP. So they have prominent speech language, potentially even apraxia speech. So, recognition of these different phenotypes is sort of a new thing in this field. There's even overlap with cortical basal syndrome and PSP, and we note that the pathology can overlap as well. So, I think that's one of the things that have changed over time. And these were- recently came out in 2017 in a new publication in the Movement Disorders Society. So, in terms of diagnostic tests as well---and there's been quite a bit of evolution---really still to date, our best diagnostic test is imaging. MRI is really one of our best tests currently. Currently blood tests, spinal fluid, there's new biomarkers in terms of skin… they're still in the research phase and not necessarily very specific yet. So, we rely heavily on imaging still; and for PSP, what we're looking for largely are changes in the brain stem, and particularly focused on the midbrain. So disproportionate midbrain atrophy compared to the pons and the rest of the midbrain is a fairly specific intensive sign for PSP. Whereas in MSA we see more of a pontine atrophy compared to the midbrain. So that can be really helpful, and there are lots of different new measurements that can be done. PET scans are also being used as well. And there are new PET markers, but they still remain kind of research-based, but are becoming more and more prevalent and may be available soon for potential use. Although there's some overlap with PET tracers with Alzheimer's disease and different Tau isoforms. So, something to be wary about, but we will be seeing some of these soon coming out as well. More kind of up-to-date things include things like the spinal fluid as well as even some of the skin biopsies. And I think we've heard some word of recent studies that have come out that potentially in the very near future we might actually have some Tau protein tests that we can look at Tau either in spinal fluid or even in a skin biopsy. But again, still remains research-based and, we still need more information as to whether these tests can be reproducible and how sensitive or specific they are. Dr Monteith: It sounds like, when really approaching these patients, still, it's a lot of back to the history, back to the clinical and some basic imaging that we should be able to identify to distinguish these types of patients, and we're not quite where we need to be yet for biomarker. Dr Farland: I totally agree with you. I think it starts, really, with the clinical exam and that's our main focus here; and understanding some of the new clinical criteria which are more sensitive, but also specific, too. And they're really useful to look at. So, I think reviewing those; patients do progress, following them over time can be really useful. And then for diagnosis, getting imaging if you suspect a patient has an atypical presentation of parkinsonism, to look for signs or features that might be specific for these different disorders. Dr Monteith: Why don't we take a typical case, a typical patient that you would see in clinic, and walk us through the thought process---especially, maybe they presented somewhat early---and the different treatment approaches to helping the patient, and of course their family. Dr Farland: Yeah, sure. So, a typical patient might be someone who comes in with, like, a three year history of progressive gait problems and falling. And let's say the patient says, I'm falling backwards frequently. They may have had, like, a rib fracture, or they hit their head once, and they're describing some speech issues as well. Now they're relying on a walker and family members saying they rarely let them be by themselves. And there may be some slowing of their cognitive function and maybe a bit of withdrawal. So that's a typical patient. So, the approach here is really, what are some of the red flags? I think already you hear a red flag of a rapidly progressive disease. So, Parkinson's disease patients rarely have frequent falls within the first five years. So, this is within three years or less. You're already hearing early onset of gait problems and falling, and particularly falling backwards rather than forwards as often Parkinson's disease patients do. You're hearing early speech problems and maybe a subtle hint of cognitive slowing and some withdrawal. So, a lot of things that sort of are red flags. So, our approach really would be examining this patient really closely. Okay? We'd be listening to the history, looking at the patient. One thing is that some of these patients come in, they may be in a wheelchair already. That's a red flag for us. If they're wearing sunglasses---sometimes we see that patients, they have photosensitivity and they're in a chair and they're wearing sunglasses---you take the glasses off and you look at their face and they have that sort of a facial stare to them---not just the masked face, but the stare---and their eyes really aren't moving. So, another kind of clue, maybe this is probably something atypical, particularly PSP is what I'm thinking about. So, the approach is really, do a thorough exam. I always recommend looking at eye movements and starting with volitional saccades, not giving them a target necessarily, but asking them to look up and then look down. And then particularly look at the speed of downgaze and whether they actually have full versions down, are able to do that. That's probably your most sensitive test for a patient who has PSP. Not the upgaze, which can be- upgaze impairment in older patients can be nonspecific. So, look for that down gaze. So, if I can get out one message, that's one thing that can be easily done and examined fairly quickly for diagnosis of these patients. And then just look for signs of rigidity, bradykinesia, maybe even some myelopraxia, and then look at their gait carefully so that there's a high suspicion. Again, if there's some atypical features, imaging is really important. So, my next step would be probably getting an MRI to evaluate whether- do they have brain somatrophy or other widespread atrophy or other signs? You need to think about your differential diagnosis for some of these patients as well. So, common things are common; vascular disease, you can't have vascular parkinsonism or even signs of NPH. Both of those can present with progressive gait difficulty and falls. So, the gait may look more like Parkinson's rather than ataxic gait that we see in classic PSP, but still they have early gait issues, and that can be a mimicker of PSP, So looking for both of those things in your imaging. Think about sort of autoimmune potentially causes. So, if they have a really rapid progressive cause, there are some rare autoimmune things. There have been recent reports of things like IgLON5, although there's limited cases, but we're doing more screening for some of those autoimmune causes. And then even some infectious causes like Whipples, that are rarely present like this. Okay? And have other signs and features. Dr Monteith: So, let's say you diagnose this patient with PSP and you're assessing the patients to see how you can improve their quality of life. So, what are some potential symptomatic managements that will help our patient? Dr Farland: I recommend for most all of these patients… while the literature indicates that many patients with PSP, and especially corticobasal syndrome, don't respond well to levodopa. So, the classic treatment for parkinsonism. However, we all recommend a trial of levodopa. These patients may respond partially to doses of levodopa, and we try to push the doses a bit higher. So, the recommended trial is usually a dose up to roughly 1000 milligrams of levodopa per day. And give it some time, at least two, if not actually three months of a trial. If not well-tolerated, you can back off. If there's no response at all or no improvement, then slowly back off and taper patients off and ask them to tell you whether they feel like they're actually worsening. So, many patients, sometimes, don't recognize the improvements, or family members don't recognize it until we actually taper them back off. And they may end up saying there are some other things that even recognize. Even some nonmotor benefits can be seen with levodopa. In some cases, we do keep them on levodopa, but levodopa's our best therapy for this. Dopamine agonists, MAO inhibitors, have all been sort of tried and they've been studied, but often don't really help or fail to help benefit these patients and could be fraught with some other side effects. I think many people do also turn to Amantadine as a treatment for Parkinson's, gait problems, freezing, if you see it in these disorders. Yet Amantadine is fraught with issues of side effects, including cognitive issues, and I think is not well-tolerated. But there are the rare patient who actually does respond to this or claims they respond to this. By and large, these patients relentlessly progress, unfortunately. So, beside treatment of other symptoms, I think it's really important to recognize that they require supportive cares and therapy. So, starting those early on and getting your allied healthcares kind of involved. So that includes people like physical, occupational therapy for the gait issues, the falls, occupational therapy for doing daily activities. Speech language pathology can be really a critical player for these because of the early speech and language issues, as well as swallow difficulties. Swallow is compared quickly in these patients. And so, we do recommend the screening evaluation, then often following patients either every six- or even annually, at least, with a swallow evaluation. And we recommend the fluoroscopic-guided kind of modified barium swallow for these patients. Dr Monteith: And how does that differ if, let's say, the patient had cortical basilar syndrome? What are some of the symptomatic treatments that would be high on your consideration? Dr Farland: So actually, these patients also have a very similar approach, and they often have some overlapping features. Maybe a little bit of difference in terms of the level of apraxia and some dystonic features that you see in corticobasal syndrome. So, as I mentioned earlier that these patients have a more typ- when they present, typically have a more asymmetric presentation. And one of the biggest issues is this limb apraxia. They may have abnormal movements as well as, like, the alien limb-type phenomena as well. So, the focus of therapy, while similar in the sense we focus on the parkinsonism, I do always try levodopa and try to ramp up the doses to see if it benefits. It does often fail, but it's definitely worth trying. The other focus of these patients is trying to treat symptoms. Dystonia, those features… in some cases, we can help; if it's painful or uncomfortable, muscle relaxants can be used. If it's vocal, things like Botox can be really helpful. Often times it is more palliative than actually restorative in terms of function, but still can be really helpful for patients who ask about pain and discomfort and trying to treat. And then of course, again, the focus on our supportive care. We need to build that network and build that team of folks, the therapists, the physical, occupational, and the speech therapist to help them. If they have language problems---like either in PSP or corticobasal---I'll also include my request to a speech language pathologist to work on cognitive function. That's a special, additional thing you have to ask for and then specifically request when you make a referral to a speech language pathologist. Dr Monteith: That is so important. I think keeping the simulation, keeping the social support, and I would probably guess that you would also include screening for sleep and mood disorder. Dr Farland: Absolutely. Mood disorders are really big in these diseases. Patients are suffering terribly. You do hear about labile mood in both of these diseases, particularly PSP; and even what's called pseudobulbar palsy, where the mood is not always congruent with the affect. So they may laugh or cry inappropriately, and particularly the crying can be very disturbing to family and caregivers to see that. And so, treating those things can be really important. So always asking about the mood issues. Depression in particular is something that we're very sensitive about, and there is a higher incidence of suicidal ideations. Asking about that and feeling and making sure that they are in a safe environment can be really important. Dr Monteith: Thank you so much. Dr Farland: Thank you. Dr Monteith: Today I've been interviewing Dr Nikolaus McFarland about his article on progressive supranuclear palsy and cortical basilar syndrome, which appears in the August 2025 Continuum issue on movement disorders. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.
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AP correspondent Julie Walker reports Christmas comes early to Germany.