Podcasts about worsening

BUFFALO, NY — June 18, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 12, 2025, titled “Frailty transitions in electronic health records: who first? what first?” The study, led by Fabienne Hershkowitz Sikron from Meuhedet HMO, analyzed how frailty develops over time in older adults using electronic health record data from nearly 120,000 individuals aged 65 and above. Researchers found that frailty worsened in over 13% of participants within a year, particularly among women, adults aged 85 or older, and people with chronic illnesses, while nearly 3% showed signs of improvement. The findings highlight early indicators of decline that could help guide preventive care and improve outcomes for aging populations. Frailty is a condition marked by increased vulnerability to health complications and tends to change gradually. The study used the Meuhedet Electronic Frailty Index (MEFI) to track yearly transitions in frailty among older adults in Israel. While many people remained in the same frailty category, a significant proportion experienced deterioration in just one year, and a smaller group improved. “Worsening frailty is defined as a higher frailty level one year later in 2024 compared to 2023. A new frailty deficit is defined as a deficit appearing in 2024 that was not present in 2023.” Those most at risk of worsening included adults over 85, women, individuals from lower socio-economic backgrounds, and members of the Arab sector. Additional predictors of decline included recent hospitalizations, multiple chronic diseases, and signs of cognitive or mobility issues. Importantly, the first signs of worsening were often not new chronic conditions but more manageable health deficits such as sleep disturbances, muscle weakness, hearing loss, and memory decline. Those who improved were more likely to be younger, male, from higher socio-economic backgrounds, and have fewer chronic conditions and hospitalizations. The study also found that common chronic illnesses like diabetes and hypertension were often already present and did not usually signal the beginning of frailty progression. Instead, declines in overall function and quality of life were more frequently the first new issues to appear. This suggests that early intervention on modifiable health deficits could delay or prevent further decline. This work is one of the first large-scale, real-world studies to identify both who is most likely to worsen first and what health problems typically appear first. The authors emphasize the importance of using routinely collected electronic medical data to monitor frailty and tailor care. By doing so, health providers can implement timely strategies to reduce disease burden and support aging individuals in maintaining independence. These findings support the creation of proactive health programs focused on maintaining physical strength, cognitive function, and sensory abilities. Preventing frailty progression can reduce hospitalizations, ease disease burden, and help older adults maintain independence and a higher quality of life. DOI - https://doi.org/10.18632/aging.206247 Corresponding author - Fabienne Hershkowitz Sikron - fabian_hershkowitz@meuhedet.co.il Video short - https://www.youtube.com/watch?v=4xa11ApI4ho Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Surgeon Victoria Rose has just returned to the UK today after working as a surgeon in war-torn Nasser hospital in Southern Gaza for over three weeks. She worked 14 hour days treating casualties from Israeli attacks, while dealing with severe shortages caused by the humanitarian blockade.

Story at-a-glance Research shows perceived stress significantly worsens COPD symptoms, with high stress levels quadrupling the risk of serious flare-ups requiring medical intervention Stress triggers biological changes in COPD patients, increasing inflammation markers and oxidative stress that directly damage lung tissue and impair breathing People with COPD who experience high stress levels report greater death anxiety, especially women, unemployed individuals and those lacking education about their condition Understanding your condition and building confidence in managing symptoms (self-efficacy) significantly reduces both stress levels and physical complications of COPD Simple interventions like focused breathing, symptom tracking and establishing daily routines help interrupt the stress-symptom cycle and improve quality of life

Greg Brady spoke to Reggie Cecchini, Global News Washington Correspondent about a US court on trade ruling against President Trump's tariffs. Learn more about your ad choices. Visit megaphone.fm/adchoices

Greg Brady spoke to Reggie Cecchini, Global News Washington Correspondent about a US court on trade ruling against President Trump's tariffs. Learn more about your ad choices. Visit megaphone.fm/adchoices

Listen every weekday for a local newscast featuring town, county, state and regional headlines. It's the daily dose of news you need on Wyoming, Idaho and the Mountain West — all in four minutes or less. 

Following almost three months of a complete blockade to aid in Gaza, the entire population is facing a severe risk of famine. Acute malnutrition is increasing among the starving children in the enclave. Every hour counts. UNICEF Spokesperson James Elder describes the worsening situation in Gaza.

Why more pregnant women need to be in clinical trials. Scientists are helping us see the future. Does our DNA know our future? Have your seasonal allergies gotten worse? Learn More: https://radiohealthjournal.org/medical-notes-how-our-genetics-can-predict-our-future-climate-change-is-worsening-seasonal-allergies-and-why-research-excludes-pregnant-women Learn more about your ad choices. Visit megaphone.fm/adchoices

Summer is in full swing in India, and many cities are experiencing scorching heat, fueled in part by climate change. And in India's bustling cities, as the sun sets and the worst of the day's heat subsides, a sinister threat emerges: high nighttime temperatures. But some low-tech solutions may help address the problem.  The post Hot nights are worsening India's heat crisis. But low-tech solutions show some promise. appeared first on The World from PRX.

Summer is in full swing in India, and many cities are experiencing scorching heat, fueled in part by climate change. And in India's bustling cities, as the sun sets and the worst of the day's heat subsides, a sinister threat emerges: high nighttime temperatures. But some low-tech solutions may help address the problem.  The post Hot nights are worsening India's heat crisis. But low-tech solutions show some promise. appeared first on The World from PRX.

Well, that's great to hear... ugh!See omnystudio.com/listener for privacy information.

In this episode, Alex talks about how he is always disillusioned when he's heard people on the right say that Trump is shielded from being a corrupt president because of his net worth. These people say that Trump isn't worried about money and will fight for the American people. Alex argues that this is all BS and he has the proof — a $400 million plane (gift) from Qatar, a crypto scheme, hotel deals, and more show that Trump is openly corrupt and doesn't care. 

04/27/25The Healthy Matters PodcastS04_E15 - Heat, Haze & How Climate Is Affecting Our HealthWith Special Guest:  Beth Stegora, PT, DPTAs global temperatures rise and extreme weather events become more frequent, it's not just our environment that's feeling the impact—our bodies and communities are, too.  Worsening air quality, heatwaves and supply chain disruptions are just some of the many ways climate change can have profound effects on both our physical and mental heath, making it an essential part of any conversation around public health.But as always, knowledge is power and action is the antidote, so on the next episode of the show we'll be joined by Climate Health Ambassador, Beth Stegora (PT, DPT) and she'll help us get a better understanding of these effects and give us helpful ideas on how to stay healthy and how each of us can make a positive impact on our climate's health going forward.  Since we all share this planet, we're all in this together, so there's something in this episode for everyone.  We hope you'll join us!We're open to your comments or ideas for future shows!Email - healthymatters@hcmed.orgCall - 612-873-TALK (8255)Get a preview of upcoming shows on social media and find out more about our show at www.healthymatters.org.

Alcohol can affect PMS say whaaaaat? In this episode we're going to talk about my relationship with alcohol and why I stopped drinking, and the affects of alcohol on the liver, hormones, and brain. Let's get into itttttt.@holyandhormonalpodcast

This is your afternoon All Local update on May 5, 2025.

Why is it so hard to stop scrolling… and even harder to stop watching porn?

Thousands of young people across Turkey are protesting against the jailing of Istanbul mayor Ekrem Imamoglu, President Recep Tayyip Erdogan's main rival. Many say they no longer fear prison, claiming they have nothing left to lose. University students were among the first to take to the streets after Imamoglu was detained last month. They believe his arrest was politically motivated, though the government denies this.“We are all sick and tired of the oppression that has been going on for such a while, and we are all fed up with it,” said an Istanbul university student who did not want to be named for fear of retribution.“All these things that happened to Ekrem Imamoglu and all the other political people that are sent to jail, we are just fed up. We can't take it anymore, so we are here to protest against the government.”For another student, the protests go beyond Imamoglu's case.“Everyone realises that it is not just a problem about Ekrem Imamoglu. We have a lot of problems in our country because of the economy, the inflation, because of the justice, because of the femicide, we have a lot of problems with our country,” she said.Turkey's rivalry with Iran shifts as US threats create unlikely common groundYouth defy fear of arrestThe protests are the largest seen against Erdogan's government in more than 10 years.Until now, political apathy, a weak opposition and a harsh crackdown on dissent have left few willing to challenge Erdogan's AK Party. But the country's youth are emerging as a key force for change.“They were really the ones that carried the first protests, they were the vanguards,” said Sezin Oney, a political commentator with Halk TV.Oney said many young people are losing hope due to widespread nepotism and corruption.“If you are not connected to somebody, even if you get the best education, then it does not matter; you have to have connections; this is how they are feeling," she said."They are striving for certain values; they are describing it as something that has to do with justice, with democracy, everything this government doesn't represent."Turkey's opposition calls for boycott as anti-Erdogan protests continueEconomy in free fallTurkey's youth have grown up in a country where 90 percent of the media is controlled by the state or its allies, and schools are designed to produce what Erdogan once called a loyal, pious generation.But that goal seems out of reach. “An overwhelming majority of the young people right now in Turkey prefer a pluralistic democratic system to a one-man strong system,” said Can Selcuki, head of Istanbul Economics Research, a polling firm.Selcuki said the sharp divides between secular and religious youth, once used by Erdogan to hold onto power, are fading as shared economic problems take centre stage. Turkey faces double-digit inflation and high youth unemployment.“As the economy is spiralling down, these young people find more common denominators in this worsening economy, making identity leverages disappear,” said Selcuki.“So the bad situation of the economy is bringing these young people together in a more socio-economic level, from a more class perspective.”Erdoğan tightens his grip with crackdown on protests while Europe stays silentCrackdown on dissent widensThe unrest has now spread to high schools, after the government decided to redeploy tens of thousands of teachers. Pupils in schools across the country have staged rare protests.Erdogan has reportedly asked his party to investigate the causes of the growing discontent.For now, the government is vowing to crack down. Court cases have begun against hundreds of protestors, most of them students, with prosecutors seeking up to three-year prison terms.Many detainees say they were beaten in custody, which authorities deny.New laws are also being discussed to curb further unrest. “There is a new crime they (the government) are trying to formulate, ‘disturbing the public order.' When you create this crime, then you can arrest basically anyone,” said Oney.“But I don't think it will succeed. The thing is especially the youth is thinking they have nothing to lose, they have reached their tipping point. There will be more arrests and more protests, it will be a vicious cycle, unfortunately.”Turkey is already seeing record numbers of highly educated people leave the country, but many young protestors say leaving is not an option. For them, staying and resisting is the only choice they have left.

The timing of a new maths test for would-be primary teaching students could slash enrolments, worsening teacher shortages. Education correspondent John Gerritsen has more.

Georgia farmers are expected to plant more peanuts and corn in 2025, while cotton acres are forecast to decline, and a new CoBank report says rapidly worsening expectations in agriculture are elevating economic concerns.

A bill moving through the House would delist wolves from the Endangered Species Act, and a new CoBank report says rapidly worsening expectations in agriculture are elevating economic concerns.

Everyone wants to grow their third party IVF program, but are we neglecting patient experience in the process?This week on Inside Reproductive Health, Eloise Drane, 3 time gestational carrier, MBA, and founder of Family Inceptions, shares her honest take on how responsiveness and individualized care have declined, even as demand has stabilized post-2021.Drawing from 17 years of experience running her own surrogacy agency, Eloise offers a kind but direct update on:Why patient experience is harder than ever to deliver (and how to improve it)How consolidation impacts intended parents and surrogacy wait timesThe challenges of startups and in-house agency models in IVF networksWhat she's looking for in a surrogacy agency before considering merging or acquiringWhy the “same workflows” just won't cut it for gestational carrier cyclesIf your practice or network is looking to scale GC IVF—and actually retain intended parents—this is a must-listen.

Orange County purifies wastewater to replenish its critical aquifer. Learn more at https://www.yaleclimateconnections.org/ 

N Engl J Med 2005;353:1095-1104Background: Prior trials on revascularization in patients with acute coronary syndromes without ST-segment elevation have yielded mixed results. While FRISC II and TACTICS-TIMI 18 demonstrated a significant reduction in myocardial infarction, this benefit was not observed in RITA 3. None of these trials showed a significant reduction in mortality. Further research is needed to guide treatment strategies in this population, particularly after the introduction of early use of clopidogrel and intensive lipid-lowering therapy.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Invasive versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS) trial sough to test the hypothesis that an early invasive strategy is superior to selective invasive strategy for patients with non-ST elevation myocardial infarction (NSTEMI).Patients: Eligible patients had to have all of the following: Worsening symptoms of ischemia or symptoms at rest with the last episode being 24 hours before randomization, elevated cardiac troponin T level (≥0.03 μg per liter); and either ischemic EKG changes (defined as ST-segment depression or transient ST-segment elevation exceeding 0.05 mV, or T-wave inversion of ≥0.2 mV in two contiguous leads) or a documented history of coronary artery disease.Patients were excluded if they were older than 80 years, had an indication for primary percutaneous coronary intervention or fibrinolytic therapy, hemodynamic instability or overt congestive heart failure, oral anticoagulant drugs use in the past 7 days, fibrinolytic treatment within the past 96 hours, percutaneous coronary intervention within the past 14 days, elevated bleeding risk, plus others.Baseline characteristics: The trial randomized 1,200 patients from 42 Dutch hospitals – 604 randomized to early invasive strategy and 596 randomized to selective invasive strategy.The average age of patients was 62 years and 74% were men. Approximately 39% had hypertension, 14% had diabetes, 35% had hyperlipidemia, 23% had prior myocardial infarction and 41% were current smokers.Approximately 48% of the patients had ST deviation equal to or greater than 0.1 mV.Procedures: Patients were randomly assigned in a 1:1 ratio to undergo early invasive vs selective invasive strategy.Patients received 300 mg of aspirin at the time of randomization, followed by at least 75 mg daily indefinitely, and enoxaparin (1 mg/kg for a maximum of 80 mg) subcutaneously twice daily for at least 48 hours. The early use of clopidogrel (300 mg immediately, followed by 75 mg daily) in addition to aspirin was recommended to the investigators after the drug was approved for acute coronary syndrome in 2002. Intensive lipid-lowering therapy, preferably atorvastatin 80 mg daily or the equivalent was recommended as soon as possible after randomization. All interventional procedures during the index admission were performed with the use of abciximab.Patients assigned to the early invasive strategy were scheduled to undergo angiography within 24 - 48 hours after randomization. Patients assigned to the selective invasive strategy underwent coronary angiography if they had refractory angina despite optimal medical therapy, hemodynamic or rhythm instability, or significant ischemia on pre-discharge exercise test.In both groups, percutaneous coronary intervention (PCI) was performed when appropriate, without providing more details in the manuscript.The level of creatine kinase MB was measured at 6-hour intervals during the first day, after each new clinical episode of ischemia, and after each percutaneous revascularization procedure.Endpoints: The primary endpoint was a composite of all-cause death, myocardial infarction, or rehospitalization for angina at 1-year.The estimated sample size to provide 80% power to detect 25% relative risk difference between the two treatment groups at 5% alpha was 1,200 patients. This assumed that 21% of the patients in the early invasive arm would experience the primary outcome.Results: During the index admission, 98% of the patients in the early invasive strategy arm underwent coronary angiogram compared to 53% in the selective invasive arm. At 1-year, 79% of the patients in the early invasive strategy arm underwent revascularization compared to 54% in the selective invasive arm.The primary outcome was not significantly different between both treatment groups (22.7% with early invasive vs 21.2% with selective invasive, RR: 1.07; 95% CI: 0.87 - 1.33; p= 0.33). All-cause death was the same in both groups (2.5%). Myocardial infarction was significantly higher with the early invasive strategy (15.0% vs. 10.0%, RR: 1.50, 95% CI: 1.10 – 2.04; p= 0.005), while rehospitalization for angina was lower with early invasive (7.4% vs. 10.9%, RR: 0.68, 95% CI: 0.47 – 0.98; p= 0.04). Most myocardial infarctions were revascularization related and these were significantly more frequent with early invasive (11.3% vs 5.4%). Spontaneous myocardial infarctions were 3.7% with early invasive and 4.6% with selective invasive and this was not statistically significant.Major bleeding, not related CABG, during the index admission was more frequent with the early invasive strategy (3.1% vs 1.7%).There were no significant subgroup interactions for the primary outcome, including based on ST deviation and troponin levels.Conclusion: In patients with NSTEMI, an early invasive strategy was not superior to selective invasive strategy in reducing the composite endpoint of all-cause death, myocardial infarction, or rehospitalization for angina at 1-year. An early invasive strategy was associated with more myocardial infarctions with a number needed to harm of 20 patients, which was secondary to revascularization related myocardial infarction. An early invasive strategy reduced rehospitalization for angina with a number needed to treat of approximately 29 patients.The ICTUS trial showed that revascularization can cause harm and highlighted how counting procedural myocardial infarctions can influence outcome estimates. While there is ongoing debate about the significance of periprocedural myocardial infarctions, evidence indicates an association with increased mortality. Whether periprocedural myocardial infarctions are 'less severe' than spontaneous myocardial infarctions remains controversial, as their impact varies based on infarct size and patient characteristics. This underscores the importance of including all-cause mortality or advanced systolic heart failure as endpoints in trials of revascularization.Patients in ICTUS received better background medical therapy compared to prior trials in this area. While this could be responsible for the divergent results compared to other prior trials. It also highlights the heterogeneity of NSTEMI patients and that an invasive strategy is not appropriate for all.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

Previously shared as a paid newsletter in May 2024. In previous newsletters, I've addressed many of the more common contributing factors to brain symptoms, including high pyrroles, copper-zinc imbalances, methylation imbalances, candida overgrowth, mast cell activation, mold and other forms of toxicity, and genetic variants, such as COMT and MAOA.Supplements can be needed to address each of these. Medication can also be necessary when treating mold and mast cell activation.But what happens when someone can't tolerate a supplement or medication because it worsens or creates new brain symptoms? Why, for example, could someone have problems tolerating B6 or SAMe or Methionine. Why might someone have problems with folate, niacinamide, glutathione, certain herbal treatments, antidepressants such as SSRIs, probiotics, antifungal medication or binders such as bentonite clay, activated charcoal, chlorella or cholestyramine?In this newsletter, I'll discuss:* Five common reasons a supplement or medication may worsen symptoms.* Specific supplements and medications that are more likely to do this.* How reactions may point to root causes.* Treatment steps that can improve tolerance.There can be a wide range of brain symptoms that can occur when someone is having an adverse reaction, such as fatigue, brain fog, depression, anxiety, agitation, and even psychosis or mania. I'll use “reactivity” to refer to this range of possibilities. While physical side effects can also occur, the focus here will be on brain symptoms.5 Common Reasons Supplements or Meds May Worsen Symptoms1. Immune ReactivityOur immune system is intertwined with our central nervous system. When our body's immune system reacts to a toxin, microbe, injury, or trauma, we can have inflammatory brain and physical symptoms.“Feel Like I'm Reacting to Everything” - Mast Cell ActivationIf someone is experiencing severe immune reactivity, such as mast cell activation, they may react to many supplements and medications, as well as triggers in their environment and stress. The number of triggers can help point to an exaggerated immune response. In my practice, this high immune reactivity is usually driven by mold toxicity.For many with this obstacle, starting very low and slow can prevent reactions. For others, interventions may be needed to lower immune reactivity and stabilize mast cells. This, however, can require certain supplements. For those who can't tolerate those treatments, limbic system retraining programs help calm the immune system so people can move forward more easily.Sensitivity & IntoleranceIt is possible to have immune sensitivity (or even allergy) to a supplement, though I find this less common. Herbal supplements, for example, which are high in salicylates, may cause symptoms in those with salicylate sensitivity. Certain probiotics have bacterial strains high in histamine. This is an issue for those with histamine intolerance.2. Too Much or Too Little Neurotransmitter ActivitySome people with brain symptoms have high neurotransmitter (NT) activity, and some have low. Common NT's include serotonin (5-HT), dopamine (DA), and norepinephrine (NE). I use the term “neurotransmitter activity” because it's not just about the amount of neurotransmitters present; it's also about the amount of receptors present that pick up NTs and remove them from the space between nerve cells.High Neurotransmitter ActivityToo much neurotransmitter activity can cause brain symptoms such as mania, psychosis, agitation, anxiety, panic, obsessions, compulsions, and hyperactivity. Reactions can occur if supplements or medications are given that further increase NT activity.Examples include:* Overmethylation* Slow COMT (involved in clearing DA and NE) and/or slow MAOA (involved in clearing 5HT, DA and NE)A variant on COMT and/or MAOA doesn't mean they are being expressed.What Increases Neurotransmitters?* SSRIs (Selective Serotonin Reuptake Inhibitor) increase serotonin activity* SNRIs (Serotonin and Norepinephrine Reuptake inhibitors) increase serotonin and norepinephrine activity.* Stimulant medications such as Ritalin and Adderall increase dopamine activity* SAMe and methionine increase serotonin and dopamine activityRemember that there can be times when there is a mixed picture, such as when someone is undermethylated and has a slow COMT.Low Neurotransmitter ActivityReactions can occur if supplements or medication decrease the neurotransmitter activity when it is already low. This could look like depression, apathy, fatigue, and brain fog.Examples include:* Undermethylation* Fast COMT (involved in clearing DA and NE) and/or fast MAOA (involved in clearing 5HT, DA and NE). The NTs are getting cleared too fast.What Decreases Neurotransmitters?* Folate, a nutrient that is good for a lot of people happens to be a big problem for many with psychiatric conditions. Most with underemethylation have low serotonin symptoms (depression and/or anxiety). While folate can help methylation, as an unfortunate aside, it can also further lower serotonin activity. Folate is in most multivitamins and B Complex vitamins. To learn more: Undermethylation, MTHFR & The Great Folate Debate.* Niacinamide can lowers DA and NE.Looking closely at someone's symptoms and traits and assessing methylation through bloodwork can help determine if NTs are too high, low, or mixed and what types of treatment to consider.3. Poor Detoxification or Toxic OverloadZincZinc is one of the most powerful tools I use in my work. Some people can easily tolerate it, while others can struggle. Here are some reasons someone may not tolerate zinc.* High copper—Zinc mobilizes copper. Moving too much copper at once can increase copper symptoms (anxiety, anger, hyperactivity, insomnia).* High toxicity—Zinc is a strong antioxidant. It is needed for the genetic expression of one of the most important antioxidants in our body, metallothionein.It took me 8 months to get my dose up to an optimal range, which is certainly not the norm. I unknowingly had significant mold toxicity at the time.When I start someone on zinc, I slowly build it up over 3-4 weeks. For some (like myself), even this is too fast.GlutathioneThis is the other major antioxidant. If someone is having difficulty tolerating it, they may have problems with detoxification and significant toxicity (metals, biotoxins like mold, and chemicals). These can start to be addressed in several other ways.BindersThese include bentonite clay, chlorella, activated charcoal, and cholestyramine. They bind toxins, especially mold toxins, in the GI tract. If they are started too quickly, the toxins they are supposed to remove get stirred up, which stirs up symptoms. When people say they can't tolerate certain binders, they usually weren't started low enough.There are others, but these are the most common in my experience.4. Underlying Microbial or Microbiome IssueB6B6 is very important for brain health. It is needed for making serotonin, dopamine, and GABA. We use it in all the Walsh nutrient protocols to varying degrees. In the last 10 years, we've seen a decrease in B6 tolerance. It's not clear why. I'm including it in this section because the reactivity is suspected to be related to the microbiome. Perhaps in recent years, we have had collective damage to our microbiomes from toxins and rising EMF exposure. We don't know.The good news is that P5P, the active form of B6, is usually well tolerated. In my practice, I rely heavily on P5P. I will occasionally use it in combination with B6 (if tolerated) for those with especially high pyrroles.Methionine and/or SAMeBoth are used, though usually not together, to help address undermethylation. I suspect candida or mold when someone is having difficulties tolerating either of these. These nutrients are usually better tolerated once candida and/or mold are addressed (or are starting to get addressed).5. Die-OffAnything that kills off microbes, such as candida or mold, can cause a “die off” of those microbes, release toxins, and worsen symptoms. Antifungal supplements, antifungal medication, and probiotics may cause this type of reactivity. Antifungal medications include nystatin, diflucan, itraconazole, and amphotericin B.Herbs and food-based supplements can have antimicrobial effects. Turmeric is one example. There are many others, so it's always worth checking. Worsening symptoms might point to an underlying fungal or other microbial overgrowth. It may also suggest that appropriate binders may be needed first.Addressing or preventing die-offs could mean supporting detoxification, starting binders if necessary, and, again, starting low and going slow.Antidepressants, interestingly, have been shown in labs to have antifungal effects. This does make me wonder if some people who can't tolerate them are having die-off.Root CausesKnowing someone's history of reactions can help point to underlying root causes.As you can see, there are typically ways to help someone tolerate and go on to benefit from a needed supplement or medication.As always, I welcome your thoughts and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Morse code transcription: vvv vvv Man whose Luton house was stolen gets possession back Scotlands former First Minister Nicola Sturgeon to step down as MSP at 2026 Holyrood election Is the US headed into a recession under Trump Worsening mental ill health behind rising welfare bill, report says Amazon rainforest cut down to build highway for COP climate summit Essex Boys murderer Michael Steeles release is blocked Lunar eclipse to grace pre dawn sky Children should avoid drinking slushies with glycerol, says review Arrested ships captain is Russian national, owners say Greenlands opposition wins election dominated by independence and Trump

Morse code transcription: vvv vvv Scotlands former First Minister Nicola Sturgeon to step down as MSP at 2026 Holyrood election Arrested ships captain is Russian national, owners say Essex Boys murderer Michael Steeles release is blocked Worsening mental ill health behind rising welfare bill, report says Is the US headed into a recession under Trump Greenlands opposition wins election dominated by independence and Trump Amazon rainforest cut down to build highway for COP climate summit Children should avoid drinking slushies with glycerol, says review Man whose Luton house was stolen gets possession back Lunar eclipse to grace pre dawn sky

Morse code transcription: vvv vvv Arrested ships captain is Russian national, owners say Lunar eclipse to grace pre dawn sky Greenlands opposition wins election dominated by independence and Trump Man whose Luton house was stolen gets possession back Essex Boys murderer Michael Steeles release is blocked Worsening mental ill health behind rising welfare bill, report says Scotlands former First Minister Nicola Sturgeon to step down as MSP at 2026 Holyrood election Amazon rainforest cut down to build highway for COP climate summit Children should avoid drinking slushies with glycerol, says review Is the US headed into a recession under Trump

Morse code transcription: vvv vvv Greenlands opposition wins election dominated by independence and Trump Man whose Luton house was stolen gets possession back Amazon rainforest cut down to build highway for COP climate summit Lunar eclipse to grace pre dawn sky Worsening mental ill health behind rising welfare bill, report says Is the US headed into a recession under Trump Arrested ships captain is Russian national, owners say Children should avoid drinking slushies with glycerol, says review Scotlands former First Minister Nicola Sturgeon to step down as MSP at 2026 Holyrood election Essex Boys murderer Michael Steeles release is blocked

Dr. Ben Thompson reveals seven common mistakes that could unknowingly be worsening your tinnitus. From inadequate sleep and stress to endlessly scrolling tinnitus forums, he explains how these habits affect your brain and hearing—plus what you can do to fix them. Get started with Treble Health:Schedule a complimentary telehealth consultation: treble.health/free-telehealth-consultation Take the tinnitus quiz: https://treble.health/tinnitus-quiz-1Download the Ultimate Tinnitus Guide: 2024 Edition: https://treble.health/tinnitus-guide-2024

This episode focuses on the ongoing and worsening crisis in Balochistan, where militancy is rising and the political process shows no signs of improving. Rafiullah Kakar joins Uzair to explain what is going on in the province, the root causes of the insurgency, and why a number of political problems have added fuel to the burning fire in Balochistan. Finally, Rafiullah also discusses his research on the structural and constitutional drivers of the core political economy issues in the province, with the conversation concluding on what can be done to alleviate the crisis in Balochistan. Rafiullah Kakar is a policy analyst currently pursuing a PhD at Cambridge University, where he is seeking to understand the political economy of sub-national state capacity through a comparative study of education policy in two Pakistani provinces: Balochistan and Khyber Pakhtunkhwa. You can read Rafiullah Kakar's paper that was discussed on the podcast here: https://www.tandfonline.com/doi/abs/10.1080/14662043.2024.2382458 Chapters: 0:00 Introduction 1:50 Worsening militancy in Balochistan 17:10 Engaging with young political leaders 25:50 India's role in the insurgency 32:20 Is the status quo secure? 36:10 Structural drivers of the issues 47:20 Devolution of power 56:00 Competition in politics

Maize is Malawi's lifeline, but soaring prices and shortages are pushing millions into hunger. Markets are empty and families can't afford their staple food. A forex crisis has crippled imports, leaving the nation struggling. How did it come to this, and what happens next?

Worsening corruption, Sanchez vs. Trump, spam calling restrictions, football controversies, Bad Bunny's triumph, and much more!Thanks for tuning in!Let us know what you think and what we can improve on by emailing us at info@rorshok.com or through Twitter @RorshokSpain or Instagram @rorshok.spain Like what you hear? Subscribe, share, and tell your buds.Rorshok Spain Update: https://rorshok.com/spain/We want to get to know you! Please fill in this mini-survey: https://forms.gle/NV3h5jN13cRDp2r66Wanna avoid ads and help us financially? Follow the link: https://bit.ly/rorshok-donate

If you've been doing everything right—going gluten-free, taking the right supplements, and following all the advice—but still struggling with fatigue, stubborn weight gain, or hair thinning… It's time to look beyond the obvious.In this episode, Inna sits down with Jen Smiley, founder of Wake Up and Read the Labels, to uncover the hidden ingredients lurking in so-called “healthy” foods that could be sabotaging your thyroid health. They break down why many gluten-free and packaged foods still contribute to inflammation, how sneaky additives like maltodextrin and “natural flavors” impact your gut, and the surprising places toxic Forever Chemicals (PFAS) are hiding in everyday foods and drinks.Plus, you'll hear how Carol, a Hashimoto's client in Thyroid Mystery Solved, turned things around by making simple swaps that finally helped her body respond—losing weight, restoring her energy, and even regrowing her hair.Press play now for really simple and actionable ways to make clean swaps that can make all the difference. Full Show notes: https://innatopiler.com/podcasts/hidden-food-ingredients-worsening-thyroid-symptoms-jen-smiley/ Please be sure you follow Inna on Instagram for everything Hashimoto's www.instagram.com/innatopilerMore at: https://innatopiler.com/

From 2019 through June 2024, more than 14,000 people filed allegations of discrimination, in employment or housing disputes, with the independent state agency. It has struggled to keep up with its caseloads, and last year, it logged a 15% increase in new filings, totaling over 3,500 claims.

Human Rights Watch (HRW) just released its annual report about the human rights situation around the world https://www.hrw.org/world-report/2025. The report points to a deterioration in rights in Central Asia in such areas as civil society, freedom of media, the judicial process, the rights of minority groups and vulnerable segments of the population, and more. Joining host Bruce Pannier to discuss the report are Syinat Sultanalieva, HRW's researcher covering Kyrgyzstan and Tajikistan, and Hugh Williamson, HRW's director for Europe and Central Asia.

A tough market for job seekers isn't set to improve until the second half of the year. The potential fall-out could be major brain drainRising unemployment and the volatile job market are set to get worse. By the time they turn around mid-year, it may be too late to keep talent in the country.…Go to this episode on rnz.co.nz for more details

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Novel Therapies to Reduce Rehospitalization Risk in Worsening Heart Failure: Systematic Review and Network Meta-Analysis.

The UN child protection agency UNICEF is warning that child abuse is worsening for thousands of children and women in conflict ravaged areas of the Democratic Republic of Congo. Ramatou Toure, UNICEF'S DRC Chief of Child Protection, told VOA's Chinedu Offor, the year is beginning on a grim note

Los Angeles is bracing for worsening wildfires as high winds forecast to create "extremely dangerous" weather conditions across coastal Southern California.

Lee Hardman, Senior Currency Analyst, and Simon Mayes, Head of UK, Ireland and Switzerland, Corporate Sales, discuss what has been behind in the sharp sell-off in global bond markets over the past week. How has the FX market been impacted by rising government borrowing costs? Disclaimer: www.mufgresearch.com (PDF)

Plus, people across North Texas connect with KRLD to share what the weather conditions are like where they live and KRLD continues to monitor for any power outages.

Pastor JD addresses why the vile and vicious divisiveness is worsening within today's church, and how that it's actually another indicator of just how close we are to the pre-tribulation rapture.

Pastor JD addresses why the vile and vicious divisiveness is worsening within today's church, and how that it's actually another indicator of just how close we are to the pre-tribulation rapture. This update will only be shown in its uncensored entirety at https://www.jdfarag.org/."LIVE STREAMING ALERT: Pastor JD's COMPLETE Bible Prophecy Update Videos will only be available at https://www.jdfarag.org/. We will continue live-streaming the first part of the Prophecy Update on YouTube then the live-stream will end, and Pastor JD will continue the live-stream with the conclusion of the update at https://www.jdfarag.org/. The best and easiest way to watch the complete updates will be to watch them in their entirety from the start of the live stream at https://www.jdfarag.org/. Please set your reminders, bookmark our website page, or fan us on Facebook when we are about to go live." Prophecy Update Links All referenced links are at http://jdfarag.orgSocial MediaProphecy Website: http://jdfarag.orgMobile/TV Apps: https://subsplash.com/calvarychapelkaneohe/appChurch Website: http://www.calvarychapelkaneohe.com/Twitter: https://twitter.com/JDFarag/Facebook: https://www.facebook.com/JDFarag/Instagram: https://www.instagram.com/JDFarag/

Alex Curry and Carmen Vitali grade the NFL trades from this week's NFL deadline on who made a great trade and who was terrible. Alex and Carmen react to Dak Prescott's injury that seems to have progressed worse and what the Cowboys are doing. Plus, the ladies talk more on that fact that Christian McCaffrey is back for the Niners, give some mid season NFL awards, make their NFL picks for this week, and more!See omnystudio.com/listener for privacy information.

Hello! Welcome back to The Anxiety Chicks Podcast. We are so blessed to have listeners like you tuning in each week. If you love the podcast, please take a moment to leave us a review—it means a lot to us! This week, we discuss how worrying too much about what others think can worsen your anxiety, along with 10 ways to stop that worrying. Taylor and Alison will share their personal experiences and times in their lives when they excessively worried about others' opinions. We explain how breaking through that mindset really opened our eyes to what truly matters. ALSO, tune in on instagram on Wednesday at 3pm EST to submit any questions you want us to answer on the weekly podcast topic! This episode is sponsored by: Addyi: Go to Addyi.com to learn more! Follow us: The Anxiety Chicks: @theanxietychicks https://www.instagram.com/theanxietychicks/?hl=en Taylor Barone: @health_anxiety https://www.instagram.com/health_anxiety/?hl=en Alison Seponara: @theanxietyhealer https://www.instagram.com/theanxietyhealer/?hl=en Learn more about your ad choices. Visit megaphone.fm/adchoices

Is the media finally figuring out how to cover Donald Trump's mental unfitness for the presidency? First, CNN's Jake Tapper dressed down a Trump surrogate for whitewashing Trump's threat to unleash the military on his enemies. Then Trump held a strange town hall at which he abruptly stopped answering questions, which generated aggressive media coverage. And Kamala Harris has directly engaged on Trump's mental state in a new way, drawing media attention to it. We talked to Brian Beutler, who often criticizes the media on his Off Message Substack, about the increasing signs that the press is treating Trump's mental decline as a big story. Listen to this episode here. Learn more about your ad choices. Visit megaphone.fm/adchoices

Did you know changing your diet can dramatically reduce ADD/ADHD symptoms? In this episode, I look back on my conversations with Dr. George Papanicolaou, Dr. Jaquel Patterson, and Dr. Uma Naidoo on how sugar, gluten, and toxins like heavy metals are disrupting brain function and fueling these chronic disorders. You'll discover the power of nutrient-dense foods, gut health, and functional medicine in managing ADD and ADHD naturally. If you're looking for solutions beyond medication, this episode gives you the tools to start healing from the inside out. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman's Weekly Longevity Journal Full-length episodes of these interviews can be found here: Why ADHD Is Not A Psychiatric Disorder Or Brain Disease with Dr. George Papaicolaou What's Fueling Our Mental Health Crisis and How Can We Fix it? With Dr. Jaquel Patterson Is Food to Blame for Your Anxiety and Depression? This episode is brought to you by AX3, Mitopure, Seed, and OneSkin. Get 20% off your first order of AX3's astaxanthin at ax3.life/hyman with code HYMAN at checkout. Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10. Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic. Unlock your healthiest skin yet. Try OneSkin with 15% off your first purchase using code HYMAN15 at OneSkin.co today. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week's Economic Update, Professor Richard Wolff discusses Kate Pickett's and Richard Wilkinson's best-selling study in the book "The Spirit Level" (2009), showing how economic inequality correlates with most of the major social problems of our time.  We will juxtapose their latest paper "The Spirit Level at 15: The Enduring Impact of Inequality" Which details how economic inequality has only gotten worse since the past fifteen years, despite government laws and programs aimed to "reduce" inequality.  Wilkinson and Pickett show how inequality leads to severe social ills, divisions, and disintegration. What we need is to face that it is capitalism that generates the inequality that generates the hostilities and social tensions intruding upon and damaging our lives." Important reading "The Spirit Level at 15: The Enduring Impact of Inequality: https://eprints.whiterose.ac.uk/215026/1/The_Spirit_Level_at_15_2024_FINAL.pdf    The d@w Team Economic Update with Richard D. Wolff is a DemocracyatWork.info Inc. production. We make it a point to provide the show free of ads and rely on viewer support to continue doing so. You can support our work by joining our Patreon community: https://www.patreon.com/democracyatwork Or you can go to our website: https://www.democracyatwork.info/donate   Every donation counts and helps us provide a larger audience with the information they need to better understand the events around the world they can't get anywhere else. We want to thank our devoted community of supporters who help make this show and others we produce possible each week. We kindly ask you to also support the work we do by encouraging others to subscribe to our YouTube channel and website: www.democracyatwork.info