Podcasts about Kura

Kisah perlombaan yang mengajarkan ketekunan dan kesabaran lebih berharga daripadakesombongan. Siapa yang kamu jagoin di lomba lari, kelinci cepat atau kura-kuralambat? Tapi tunggu dulu… kadang konsistensi lebih hebat dari sekadarkecepatan. Mau tahu kenapa si kura-kura bisa jadi pemenang?

Nesta edição dou a ouvir musica nova de Tom Enzy, Kura, KREAM, Steve Angello, Max Styler, Chris Lake, Adam Sellouk, B Jones, ARTBAT & Alok, Hugel e muito mais.Subscreve o Dance Sessions na Apple Podcasts para o download exclusivo, são 60 minutos de música electronica semanais, segue a playlist semanal no Spotify ou na Apple Music ainda no TikTok e Instagram.http://spoti.fi/2Aacg8K http://apple.co/2y1RUwE Hosted on Acast. See acast.com/privacy for more information.

Mīms, kura sejai pat nav vajadzīgs grims, kustību režisors, pedagogs, vizionārs, intelektuālais disidents mūzikā, jumtu staigātājs – Ansis Rūtentāls (1949–2000). Grāmatu par viņu sarakstījusi viena no kustību teātra („Kustoņu") dalībniecēm Guna Bīriņa, daudz sarunājoties ar laikabiedriem un izmantojot ierakstus Mīmu ansambļa un Kustību teātra dienasgrāmatās. Neatņemama sastāvdaļa ir apstādināti kustību izrāžu un videofilmu kadri. Grāmatas struktūru veido Anša Rūtentāla izrādes "Krāsas (Noskaņu spēles). Ceļojums" (1982) sižetiskā līnija. Saglabājot izrādes daļu oriģinālos nosaukumus un pakārtojot tiem Rūtentāla dzīves posmus. Grāmatas nosaukums „Ansis Rūtentāls. Ceļojums". Izdevis „Neputns". Monogrāfiju ievada teātra zinātnieces Edītes Tišheizeres priekšvārds par Ansi Rūtentāla un viņa nozīmi Latvijas teātra vēsturē. Gundars Āboliņš lasa gan par jumtiem, gan izrāžu tapšanu kustībā, gan mīlestību, bet pats viņš atceras Anša Rūtentāla izcilo mūzikas gaumi. Raidījumu atbalsta:

Autaia gives rangatahi a chance to explore their creativity by coming up with a story they want to tell and working out how to tell that tale through haka, dance and theatre. 

JCO PO author Dr. Alison M. Schram at Memorial Sloan Kettering Cancer Center shares insights into her JCO PO article, “Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors.” Host Dr. Rafeh Naqash and Dr. Schram discuss relevant genomic and clinical features of patients with BRCA-altered uterine sarcoma and the efficacy of PARPis in this population. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and associate professor at the OU Health Stephenson Cancer Center. Today, we are excited to be joined by Dr. Alison Schram, Associate Attending Physician and Section Head of Oral Therapeutics with Early Drug Development and Gynecologic Medical Oncology Services at the Memorial Sloan Kettering Cancer Center, and the senior author of the JCO Precision Oncology article titled, "Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors." At the time of this recording, our guest's disclosures will be linked in the transcript. Dr. Schram, thank you for joining us today. I am excited to be discussing this very interesting, unique topic based on what you published in JCO PO. Dr. Alison Schram: Thank you for having me. Dr. Rafeh Naqash: What we like to do for these podcasts is try to make them scientifically interesting but at the same time, keep them at a level where our trainees and other community oncology professionals understand the implications of what you've published. So I'd like to start by asking you, what is leiomyosarcoma for those of us who don't necessarily know a lot about leiomyosarcoma, and what are some of the treatment options for these uterine sarcomas? Dr. Alison Schram: Uterine leiomyosarcoma is a rare subtype of uterine cancer, and it represents about 1% of all female cancers in the reproductive tract. This is a rare malignancy that arises from the myometrial lining of the uterus, and it is generally pretty aggressive. In terms of the standard therapy, the standard therapy for uterine leiomyosarcoma includes chemotherapy, generally combination chemotherapy, but despite a few regimens that tend to be effective, the duration of effectiveness is relatively short-lived, and patients with advanced uterine leiomyosarcoma eventually progress and require additional therapy. I will say that localized uterine leiomyosarcoma can be treated with surgery as well. Dr. Rafeh Naqash: Thank you for that description. Now, there are two aspects to what you published. One is the sarcoma aspect, the leiomyosarcoma, and the second is the BRCA mutation. Since we are a precision medicine journal, although we've discussed BRCA a couple of times before, but again, for the sake of our listeners, could you highlight some of the aspects of BRCA and PARP sensitivity for us? Dr. Alison Schram: Yes. So BRCA is a gene that's important for DNA repair, and BRCA mutations can be either inherited as a germline mutation, so one of your parents likely had a BRCA mutation and you inherited one copy. In patients who have an inherited BRCA mutation, the normal cells tend to have one abnormal copy of BRCA, but if a second copy in the cell becomes altered, then that develops into cancer. And so these patients are at increased risk of developing cancers. Specifically, they are at an increased risk of developing ovarian cancer, breast cancer, prostate cancer, pancreatic cancer, and a few others. These cancers are considered BRCA-associated tumors. Alternatively, some patients, more rarely, can develop BRCA-altered cancers completely sporadically. So it's a mutation that happens in the tumor itself, and that can lead to impaired DNA repair and promote cancer progression. And those patients are not, they don't have any inherited risk, but just a random event caused a BRCA mutation in the tumor. The reason this is important is because, in addition to it being potentially important for family members, there are certain treatments that are more effective in BRCA-altered cancers. And the main example is PARP inhibitors, which are small molecule inhibitors that inhibit the PARP enzyme, and there is what we call synthetic lethality. So PARP is important for DNA repair, for single-stranded DNA repair, BRCA is important for double-stranded DNA repair, and in a patient that has a cancer that has a BRCA mutation, that cancer becomes more reliant on single-stranded DNA repair. And if you inhibit it with a PARP inhibitor, the cancer cells are unable to repair DNA, and the cells die. So we call that synthetic lethality. PARP inhibitors are FDA approved in several diseases, predominantly the BRCA-associated diseases I mentioned: breast cancer, ovarian cancer, pancreatic cancer, and prostate cancer. Dr. Rafeh Naqash: That was very beautifully explained. Honestly, I've heard many people explain BRCA before, but you kind of put it in a very simple, easy to understand format. You mentioned this earlier describing germline or hereditary BRCA and somatic BRCA. And from what I gather, you had a predominant population of somatic BRCA, but a couple of germline BRCA as well in your patient population, which we'll go into details as we understand the study. You mentioned the second hit on the germline BRCA that is required for the other copy of the gene to be altered. In your clinical experience, have you seen outside of the study that you published, a difference in the sensitivity of PARP for germline BRCA versus a somatic BRCA that has loss of both alleles? Dr. Alison Schram: So we will get into what's unique about uterine sarcomas in just a minute. In uterine sarcomas, what we have found is that the BRCA mutations tend to be somatic and not germline, as you mentioned. That is in contrast to the other diseases we mentioned, where the vast majority of these tumors are in patients that have germline BRCA alterations. So one thing that's really unique about the uterine sarcoma population and our paper, I believe, is that it is demonstrating an indication for PARP inhibitors in a population that is not characterized by germline BRCA alterations, but truly these by somatic BRCA alterations. If you look at the diseases that PARP inhibitors are validated to be effective in, including the, you know, the ones I mentioned, the BRCA-associated tumors, there's some data in specific context that suggests that perhaps germline alterations are more sensitive to PARP inhibitors, but that's not universal, and it's really tricky to do because the genetic testing that we have doesn't always tell you if you have two hits or just one hit. So you need more complex genetic analysis to truly understand if there is what we call a biallelic loss. And sometimes it's not a second mutation in BRCA. Sometimes it's silencing of the gene by hypermethylation or epigenetics. Some of our clinical trials are now incorporating this data collection to really understand if biallelic loss that we can identify on more complex genetic testing predicts for better outcomes. And we think it's probably true that the patients that have biallelic loss, whether it be germline or somatic biallelic loss, are more likely to benefit from these treatments. That still needs to be tested in a larger cohort of patients prospectively. Dr. Rafeh Naqash: In your clinical experience, I know you predominantly use MSK-IMPACT, but maybe you've perhaps used some other NGS platforms, next-generation sequencing platforms. Have you noticed that these reports for BRCA alterations the report mentioning biallelic loss in certain cases? I personally don't- I do lung cancer, I do early-phase lung cancer as well, but I personally don't actually remember if I've seen a report that actually says biallelic loss. So after this podcast, I'm going to check some of those NGS reports and make sure I look at it. But have you seen it, or what would be a learning point for the listeners there? Dr. Alison Schram: Exactly. And they usually do not. They usually do not explicitly say, “This looks like biallelic loss,” on the reports. The exception would be if there's a deep deletion, then that implies both copies of the gene have been deleted, and so then you can assume that it's a biallelic loss. But oftentimes, when you see a frameshift alteration or a mutation, you don't know whether or not it's a biallelic loss. And you may be able to get some clues based on the variant allele frequencies, but due to things like whole genome duplication or more complex tumor genomics, it's not clear from these reports, and you really do need a more in-depth bioinformatic analysis to understand whether these are biallelic or not. So that is why I suggest that this really needs to be done in the context of a clinical trial, but there is definitely a theoretical rationale for reporting and treating patients with biallelic losses perhaps more so than someone who has a variant of unknown significance that seems to be monoallelic. The other tricky part, as I mentioned, is the fact that there could be epigenetic changes that silence the second copy, so that wouldn't be necessarily evident on a DNA report, and you would need more complex molecular testing to understand that as well. Dr. Rafeh Naqash: Sure. Now, going to your study, could you tell us what prompted the study, what was the patient population that you collected, and how did you go about this research study design? Dr. Alison Schram: It's actually a great story. I was the principal investigator for a clinical trial enrolling patients regardless of their tumor type to a combination of a PARP inhibitor and immunotherapy. And this was a large clinical trial that was being done as a basket study, as I mentioned, for patients that have either germline or somatic alterations with advanced solid tumors that had progressed on standard therapy. And the hypothesis was that the combination of a PARP inhibitor and immunotherapy would be synergistic and that there would be increased efficacy compared to either agent alone and that patients who had BRCA alterations were a sensitive population to test because of their inherent sensitivity to PARP inhibitors and perhaps their increased neoantigen burden from having loss of DNA repair. So this large study, it's been published, really did show that there was efficacy across several tumor types, but it didn't seem to clearly demonstrate synergy between the immunotherapy and the PARP inhibitor as compared to what you might expect from a PARP inhibitor alone, and in addition to a couple of cases, perhaps attributable to the immunotherapy. So maybe additive rather than synergistic efficacy. However, what really struck me looking at the data was that there were three patients with uterine leiomyosarcoma with BRCA deletions who had the best responses of anyone on the study. So incredible, durable responses. One of my patients with a complete response that continues to not have any evidence of cancer eight years after the initiation of this regimen. And for those of us that treat uterine leiomyosarcoma, this is unheard of. These patients generally, as I mentioned, respond, if they do respond to chemotherapy, it's generally short-lived and the cancer progresses. And so a complete response nearly a decade later turns heads in this field. The other interesting thing was that these uterine leiomyosarcoma patients had somatic alterations rather than a germline alteration with a second hit, and the diseases that are best validated for being responsive to PARP inhibitors include the BRCA-associated diseases, the ones that you're at increased risk for if you have a germline BRCA mutation, including breast, pancreas, prostate, and ovarian. And so it was very interesting that this disease type that seemed to be uniquely sensitive to PARP inhibitors with immunotherapy was also different in that patients with uterine leiomyosarcoma don't tend to have a high frequency of BRCA alterations, and in patients that are born with a BRCA alteration, there doesn't seem to be a clearly increased risk of uterine sarcomas. So this population really jumped out as a uniquely sensitive population that differed from the prior indications for PARP inhibitors. Given this patient and these couple of patients that we observed on the combination, in addition to some other case reports and case series that had started to come out in small numbers, we wanted to look back at our large cohort of patients at Memorial Sloan Kettering to see if we could really get a better sense of the numbers. How many patients at Sloan Kettering with uterine sarcomas have BRCA alterations? Are they generally somatic or germline? Are there unique features about these patients in terms of their clinical characteristics? How many of them have received PARP inhibitors, and if so, is this just luck that these three patients did so well, or is this really a good treatment option for patients with BRCA-altered uterine sarcomas? And so we did this retrospective analysis identifying the patients at Sloan Kettering who met these criteria. So in total, we found 35 patients with uterine sarcomas harboring BRCA alterations, and the majority were leiomyosarcoma, about 86% of them had leiomyosarcoma, which is interesting because there are other uterine sarcomas, but it does seem like BRCA alterations tend to be more often in the leiomyosarcomas. And 13 of these patients with uterine leiomyosarcoma were treated with PARP inhibitors in the recurrent or metastatic setting with about half of those patients having an overall response, so that's a significant tumor shrinkage that sustained, and a clinical benefit rate of 62%. And if we look at the patients that had these BRCA2 deep deletions, which was the patient I had that had this amazing response, the overall response rate jumped to 60% and the clinical benefit rate to 80%. And we defined clinical benefit rate as having maintained on the PARP inhibitor without evidence of progression at six months. So this is really impressive for patients with a difficult to treat disease. And we couldn't do a randomized controlled trial comparing it to chemotherapy, but looking retrospectively at outcomes on chemotherapy studies, this was very favorable, particularly because many of these patients were heavily pretreated. So to get a sense of, you know, how this might compare to chemotherapy, we tried to use patients as their own internal controls, and we looked at how long patients were maintained on the PARP inhibitor as compared to how long they were on the treatment just prior. And we used a ratio of 1.3 to say if they were on the PARP inhibitor for 1.3 times what their previous treatment was or longer, that is pretty clearly better, more of a benefit from that regimen. And the majority of patients did meet that bar. So 58% had a PFS ratio greater than 1.3, and the average PFS ratio was 1.9, suggesting, you know, you would expect the the later lines of therapy to actually not work as well, but this suggests that it's actually working better than the immediately prior line of therapy, to me, suggesting that this is truly a good treatment option for these patients. Dr. Rafeh Naqash: Very interesting. And you mentioned that individuals with tumors having deep deletions were probably more responsive. How did you figure out that there was biallelic loss or deep deletions? Was that part of an extended analysis that was done subsequently? Dr. Alison Schram: So the deletions reported on our report, if it's a biallelic deletion, that is the one biallelic molecular alteration that would be reported. So those are, by definition, biallelic, and I think that that may be one of the reasons that's a good biomarker. But also, what's interesting is that if you have both copies deleted of BRCA, you can't develop reversion mutations. So one of the the known mechanisms of resistance to PARP inhibitors in patients who have BRCA alterations are something called a reversion mutation where, if you have a frameshift alteration, for example, in BRCA that makes BRCA protein nonfunctional, you can develop a second mutation that actually puts the DNA back in frame, and a functional protein is now made. And so a mechanism of resistance to PARP inhibitors is actually reverting BRCA to a wild-type protein, and then BRCA's synthetic lethality no longer makes sense and is no longer effective. But if you've deleted both copies of BRCA, you don't have the ability to restore the function, and you can't develop reversion mutations. And that's perhaps why, you know, my patient and others have had these prolonged responses to PARP inhibitors because you don't have the same ability to develop that mechanism of resistance. Dr. Rafeh Naqash: I remember thinking a year and a half back, I had an individual with prostate cancer and with BRCA2, and using liquid biopsy, I had a reversion mutation that we caught. In your practice, have you seen the utility of doing the serial liquid biopsies in these individuals to catch these reversion mutations? Dr. Alison Schram: Yes, absolutely. And in patients that have the ability to develop a reversion mutation, serial cell-free DNA can catch it, but the caveat is that it doesn't always. So if you see an acquired reversion mutation in cell-free DNA, that can be helpful, particularly if you're planning on putting the patient on another line of therapy that might require a dysfunctional BRCA. So if you're putting them on a clinical trial with a PARP combination and the rationale is that they're sensitive because they don't have a functional BRCA, you would want to know if they developed a reversion mutation, and serial cell-free DNA can definitely identify these reversion mutations. Some of the major clinical trials in ovarian cancer have done serial cell-free DNA and have demonstrated the utility of that approach. The caveat is that some of these reversion mutations are not readily caught on cell-free DNA because they're more complex reversion mutations, or they're not, the part of the gene that develops the reversion mutation is not tiled on the panel. And so it doesn't always catch the reversion mutations. Also, depends on the cell-free DNA shedding, depends on the tumor volume and other factors. And we published a related paper of a patient, it was a really interesting case of a patient with prostate cancer who was on a PARP inhibitor and developed what appeared to be a single reversion mutation on one sample, had negative cell-free DNA, single reversion mutation in a tissue biopsy, and then developed disease progression. And we did an autopsy, and the patient kindly consented to an autopsy, and at the time of autopsy, there were 10 unique reversion mutations identified across 11 metastases. So almost each metastasis had a unique reversion mutation, and only one of them had been seen premortem on a tissue biopsy and not on a cell-free DNA. But that autopsy really drove home to me how much we're missing by doing clinical testing in real time and we really don't know the entire genomic complexity of our patients by doing single samples. And theoretically, cell-free DNA can catch DNA from all the metastases, so you might think that that would be a solution, and it definitely can catch reversion mutations that are not seen in a single biopsy, but you really need to do it all. I mean, you need to do the tissue biopsy sampling, you need to do cell-free DNA, and probably one cell-free DNA test is not enough. Dr. Rafeh Naqash: Thank you, again, for that very nice explanation. Now, one quick provocative question. I remember when I was training, the lab that I used to work in, they used to do a lot of phosphorylation markers for DNA damage response, like phospho NBS, RAD51. Have you seen anything of that sort on these biallelic BRCA mutations where tumors are responding, but they also have a very high signature on the phosphorylation side, and it may or may not necessarily correspond to HRD signatures, but have you noticed or done any of that analysis? Dr. Alison Schram: I think that it would be great to do that analysis. And some of the work we're doing now is actually trying to dig a little bit deeper in our cohort of patients to understand are these HRD-positive tumors? Does HRD positivity correlate with response to BRCA alterations? In terms of the functional assays, I would love to be able to do a functional assay in these samples. One of the challenges is that this was a retrospective study and many of the patients were previously treated as standard of care or off-label with these agents, and so we didn't have prospective tissue collection, and so we're really limited by the tissue that was collected as part of standard of care and the consent forms that the patient signed that allow us to do genomic and molecular testing on their samples. So, I think that is hopefully future work that we will do and others will do. Dr. Rafeh Naqash: Sure. Shifting gears to your career trajectory, I'd like to spend a couple of minutes there before we end the podcast. So Dr. Schram, you've obviously been a trailblazer in this space of drug development, early-phase trials. Can you give us a brief synopsis of your journey and how you've successfully done what you're doing and what are some of the things that drive you? Dr. Alison Schram: Well, thank you for saying that. I don't know if that's true, but I'll take the bait. I've been interested in oncology since college and was always very interested in not only the science of oncology but of course, treating patients. And in medical school, I did basic science research in a laboratory and it was very inspiring and made me want to do research in oncology in addition to clinical care. When I became an oncology fellow, I was presented with a very difficult question, which is, “Do you want to be a lab PI and be in the lab, or do you want to do clinical care and clinical research?” And I couldn't choose. I found a mentor who thankfully really had this amazing vision of combining the two and doing very early drug development, taking the data that was being generated by labs and translating it into patients at the earliest stage. So, you know, phase one drug development in molecularly targeted therapies. And so I became very interested as a fellow in early drug development and this ability to translate brand new molecular insights into novel drugs. And I joined the- at Sloan Kettering, there was the Early Drug Development, it was actually a clinic, it was called something different, and it was very fortuitous. My last year of fellowship, the clinic became its own service with the ability to hire staff at Sloan Kettering, and I was the first ever hire to our Early Drug Development Service. And that really inspired me to try and bring these drugs to patients and to really translate the amazing molecular insights that my colleagues here at Sloan Kettering are discovering, and you know, of course, at other institutions and in pharma. And you know, there 's been an amazing revolution in in drug development over the last several years, and I feel very grateful that I've been here for it. You know, I've been able to take the brilliant insights from my colleagues and put these drugs in patients, and I have the amazing privilege of watching patients in many cases that benefit from these treatments. And so I do mostly phase one drug development and molecularly targeted therapies, and truthfully, I am just very fortunate to be around such brilliant people and to have both patients and labs trust me to be able to deliver these new drugs to patients and hopefully develop better drugs that move forward through FDA approval and reach patients across the country. Dr. Rafeh Naqash: Thank you so much. That was very nicely put. And hopefully our trainees and junior faculty find that useful based on their own career trajectories. Thank you, Dr. Schram, for joining us today. Hopefully, we'll see more of your subsequent work in JCO PO. Thank you for giving us all these insights today. Dr. Alison Schram: Thank you for having me. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Dr. Alison Schram Disclosures Consulting or Advisory Role Company: Mersana, Merus NV, Relay Therapeutics, Schrodinger, PMV Pharma ,Blueprint Medicines, Flagship Pioneering, Redona Therapeutics, Repare Therapeutics, Endeavor BioMedicines Research Funding Company: Recipient: Your Institution  Merus, Kura, Surface Oncology, AstraZeneca, Lilly, Pfizer , Black Diamond Therapeutics, BeiGene, Relay Therapeutics, Revolution Medicines,  Repare Therapeutics, PMV Pharma, Elevation Oncology, Boehringer Ingelheim Travel, Accommodations, Expenses Company: PMV Pharma 

KeFrod drop a fresh #EDMRadioShow featuring music from Tim Hox, Justin Mylo ft. RESPONS, Skytech & Fafaq, Armin van Buuren & Martin Garrix ft. Libby Whitehouse, KURA, Dr Phunk & Lockdown, STVW and many more!

This morning the Government proposed big changes to secondary school qualifications, namely, scrapping NCEA. They said the new system would still retain standards-based assessments and be underpinned by a new national curriculum. We wanted to ask a student how they're feeling about this, Kapiti College Head of Kura, Aroa Al Masri spoke to Emile.

Karibu katika kipindi cha Elimu Jamii, Mwezeshaji ni Joseph Kasongwa Mwaiswelo, Mkurugenzi wa Elimu kwa Umma kutoka Taasisi ya kuzuia na kupambana na rushwa (TAKUKURU) ambapo leo tunaangazia juu ya Thamani ya kura wakati wa uchaguzi Mkuu. Studio Kuu Mikocheni mtangazaji wako ni mimi Esther Magai Hangu nikishirikiana na Geofrey Rweyunga kutpka studio ndogo Jijini […] L'articolo Je, unafahamu thamani ya ya kura yako katika kipindi cha uchaguzi Mkuu? proviene da Radio Maria.

Thuec Kura Basketball akutnhom Riëënythii Junup Thudan ciëëŋ pan Australa

Patch 11.2 is coming but everyone is busy chasing mounts first! Also, Kura made more Pandaren! (shocked pikachu face!)

This week on Sake On Air, host Cindy Bissig is joined by special guest host Julian Houseman to welcome back a familiar voice: Tom Wilson, co-founder and head brewer of Kanpai, London's first sake brewery! They recorded their conversation at Julian's sake bar, Sake House, in Umeda, Osaka. Listeners may remember Tom from “Episode #73: Future of Sake with Les Larmes du Levant & Kanpai London”, where he joined us for a lively conversation alongside Grégoire Boeuf. Now, several years later, Tom returns to share exciting updates from the Kanpai camp. In this episode, Tom reflects on his recent collaboration with a sake brewery in Nara, giving us a peek into the inspiration and process behind this unique Japan-U.K. brew, which will soon be available in both countries. He also offers insight into Kanpai's evolving philosophy and what's been happening at their new home in Peckham, London, where they continue to experiment, grow, and celebrate all things sake. And for a special treat, Tom brought along a bottle of Kanpai's 2021 vintage “Kura” sake, which was enjoyed during the recording—and let's just say, it didn't disappoint. Tune in to hear how the international sake scene continues to evolve, and what it means to brew Japanese sake with British roots. Join us for a special English / Japanese bilingual rakugo performance: https://jss-event16.peatix.com/ Subscribe to our newsletter: https://sakeonair.substack.com/ We'll be back very soon with plenty more Sake On Air. Until then, kampai! Sake On Air is made possible with the generous support of the Japan Sake & Shochu Makers Association and is broadcast from the Japan Sake & Shochu Information Center in Tokyo. Sake on Air was created by Potts K Productions and is produced by Export Japan. Our theme, “Younger Today Than Tomorrow” was composed by forSomethingNew for Sake On Air.

1^Kevin DuRard - Summer Poolside 2025 (Original Intro)2^Tommy Farrow f. House Gospel Choir - Angels (Extended Mix)3^David Guetta + Hugel f. Kehlani + Daecolm - Think Of Me (Extended Mix)4^EDX - Longlivedad (Extended Mix)5^Meduza f. Hayla - Another World (Volaris Extended Mix)6^Sistek - Nobody Like You (Topic Edit - Extended)7^Austin Leeds f. Eileen Jaime - Caliéntame (Original Mix)8^Corren Cavini - Listen to the Silence (Extended Mix)9^Lady Gagy v SAFARIS - LoveDrug v Beyond the Door (Kevin DuRard Mash-up)10^Nora En Pure f. Richard Walters - Protected (Extended Mix)11^Debbie Gibson v Croatia Squad - Tell Me Love v Into the Night (Kevin DuRard Mash-Up)12^Castlebrook - Kuja (Extended Mix) 13^Danny Verde + Eliad Cohen f. Maya Simantov - Forget You (Oscar Velazquez Extended Mix)14^Julien Fade f. Nu-La - Breathe in the Blue (Extended)15^Calvin Harris f. Clementine Douglas - Blessings (Original Mix) 16^Vintage Culture + Max Milner f. Layla Benitez - Nirvana (Original Mix) 17^Chris Lake - Savana (Extended Mix)18^Sultan + Shepard - Mio (Extended Mix)19^Sonny Fodera f. Clementine Douglas - Tell Me (Agents Of Time Extended Remix)20^Becky Hill v Milan Steenwinkel - Surrender v Inner Senses (Kevin DuRard Mash-Up)21^KURA f. Nuno Ribeiro - Eu Prometo (Extended Mix)22^Anyma f. Magnus - Leave A Mark (Extended Mix)

Presented by SmartStop Self Storage, this week's episode of SheEO Lead-In, we listen to our host, Rebecca Jones, engaging in a thought-provoking discussion with Kelly Cannan, Vice President, Human Resources, Kura Oncology. Kelly discusses her journey and insights on leadership. She emphasizes the importance of authenticity, flexibility, and positive intent in her role, which involves hiring, retaining, and engaging employees. Kura Oncology, with 225 employees, maintains a low turnover rate by focusing on core values and accountability. Kelly highlights the significance of balance, especially as a mother, and the evolving expectations of the workforce, particularly the gig economy. She advises young women to embrace their authenticity and to be intentional in their careers. Kura Oncology is notably female-dominated, with two-thirds of its leadership being women.We want to thank our incredible sponsor, SmartStop Self Storage, a leader in self storage real estate, and a company that upholds its core principles of leading together, embracing change and enhancing everyone's journey. To learn more about SmartStop, please visit SmartStop Self Storage. Thank you for being a part of the SheEO Lead-In community!  Please be sure to share our episodes and subscribe to this storage vault of wisdom and knowledge, built by women and for women.

01. Anyma, Script - In My Mind 02. Nora En Pure - Train of Thoughts 03. Tony Romera - Time To Move 04. Kvsh, Future Skies - DNA 05. Jacknife - Real 06. Kasia, Skuro (It), Arkaden - Luminate 07. Jeonghyeon, Madzi - Crazy 08. Jerro - Kick It 09. Kygo, Hayla, Joel Corry - Without You 10. Dj Kuba, Neitan, Emdi, Nicci - Drake 11. Caroline Roxy, Amero, Hallasen - Another Life 12. Capozzi - MARE 13. Melsen, Dwight Steven - One More Night 14. Body Ocean, Merc The Big Body Benz - Sauce 15. Justus - Flashback 16. Alle Farben, Maurice Lessing - Apollo 2 17. Frankie Corsano - Backroom 18. Miss Monique, Genesi, Carl Bee - Nomacita 19. Camelphat, Vomee - Needed You 20. Honu - Down and Dirty 21. Vintage Culture, Dj Glen - Brava 22. Oliver Heldens, Ian Asher, Sergio Mendes - Mas Que Nada 23. Kura, Awiin - Told You So 24. Edx - Desire 25. Alvin, Iint - Feel It 26. Freejak - My House 27. Don Diablo, Echoboy - Only God Knows 28. Haddadi Von Engst - Path to Paradise 29. Cat Dealers - Scarlett 30. Mafo - Jack The Beat 31. Bingo Players, Mohtiv - Want It All 32. Dj Varda - Fallin Love 33. Cedric Gervais, Sick Individuals - Feel Better 34. Lucas & Steve, Laura White - Are You Ready 35. Adrian Knows - Move 36. Dubdogz, Chemical Surf, Lothief - Girl On Fire 37. Crunkz, Philip Strand - Friends 38. Josement, Moti - God Of The Sun

Owen Campbell is the operations director at Kura. He is based in Glasgow, Scotland. Kura is a BPO based in the UK, but also with operations in South Africa. They have a number of clients from various regulated industries and Owen talked to Mark Hillary about the differences between a client that has complete control over all their services and a client from a more regulated environment. What needs to be considered when working to design CX for a regulated industry? https://www.linkedin.com/in/owen-campbell-a4602b173/ https://www.wearekura.com/   SUMMARY Mark Hillary and Peter Ryan discuss the complexities of customer experience (CX) in regulated industries with Owen Campbell, Operations Director at Kura, a BPO focused on culture and people development. Campbell highlights Kura's work with heavily regulated sectors like healthcare, utilities, and financial services, emphasizing the importance of compliance and agent training. He notes that while innovation may take longer in regulated environments, it is still possible. Campbell also discusses Kura's strategic planning sessions, the importance of data security, and the shift towards outcome-based models for advisors. He predicts increased use of AI and automated compliance in the coming years.

01. Anyma, Script - In My Mind 02. Nora En Pure - Train of Thoughts 03. Tony Romera - Time To Move 04. Kvsh, Future Skies - DNA 05. Jacknife - Real 06. Kasia, Skuro (It), Arkaden - Luminate 07. Jeonghyeon, Madzi - Crazy 08. Jerro - Kick It 09. Kygo, Hayla, Joel Corry - Without You 10. Dj Kuba, Neitan, Emdi, Nicci - Drake 11. Caroline Roxy, Amero, Hallasen - Another Life 12. Capozzi - MARE 13. Melsen, Dwight Steven - One More Night 14. Body Ocean, Merc The Big Body Benz - Sauce 15. Justus - Flashback 16. Alle Farben, Maurice Lessing - Apollo 2 17. Frankie Corsano - Backroom 18. Miss Monique, Genesi, Carl Bee - Nomacita 19. Camelphat, Vomee - Needed You 20. Honu - Down and Dirty 21. Vintage Culture, Dj Glen - Brava 22. Oliver Heldens, Ian Asher, Sergio Mendes - Mas Que Nada 23. Kura, Awiin - Told You So 24. Edx - Desire 25. Alvin, Iint - Feel It 26. Freejak - My House 27. Don Diablo, Echoboy - Only God Knows 28. Haddadi Von Engst - Path to Paradise 29. Cat Dealers - Scarlett 30. Mafo - Jack The Beat 31. Bingo Players, Mohtiv - Want It All 32. Dj Varda - Fallin Love 33. Cedric Gervais, Sick Individuals - Feel Better 34. Lucas & Steve, Laura White - Are You Ready 35. Adrian Knows - Move 36. Dubdogz, Chemical Surf, Lothief - Girl On Fire 37. Crunkz, Philip Strand - Friends 38. Josement, Moti - God Of The Sun

Rei had a good pug, Kura had a bad pug. Eric's tank is back in action and Nick is ranting about leveling.

W orędziu premiera Tuska padło słowo kohabitacja. Plan awaryjny, zakładający trudną kohabitację z prezydentem, jest przygotowany. Co to jest ta kohabitacja? Słowo to składa się z trzech części: pierwszej, na początku, drugiej w środku i trzeciej na końcu. Pierwsza część to ko. Kura robi ko, ko, ale w tym przypadku ko, znaczy KO, czyli Koalicja Obywatelska.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. Roche and Jazz Pharmaceuticals presented data at ASCO showing that their drug combination improved survival in a phase III lung cancer trial, with analysts noting a strong treatment effect. Jazz has filed for FDA approval for the combination, which could provide an alternative to monotherapy treatments from Roche and AstraZeneca. Trump's tariffs could potentially endanger the rare disease space, according to industry experts. Other news includes Kymera's success with a protein degrader candidate, Amgen's IMDelltra boosting survival in small cell lung cancer, and concerns about the impact of FDA guidelines on nitrosamine testing. BioAgilytix will be at BIO International to discuss their drug production capabilities. Other news includes Kura's new data in acute myeloid leukemia, Keros' layoffs, Regeneron's investment in a Chinese obesity drug, and Sanofi's acquisition of Blueprint to expand their rare disease portfolio. Upcoming events include webinars on AI in life science R&D and the crisis facing the pharma industry. Job opportunities in clinical data management, regulatory affairs, and scientific roles are also highlighted.

Il-Ġimgħa tal-Kura Paljattiva din is-sena kellha t-tema x'inhu l-pjan tiegħek, bil-għan li tinħoloq konverżazzjoni dwar it-tmiem tal-kura fil-ħajja. Parti minn din id-diskussjoni tista' tinkludi u timplimenta użanzi u tradizzjonijiet xierqa li għadhom x'jaqsmu mal-mewt għall-individwi u l-familji tagħhom.

Městečko Mccheta leží na soutoku řek Kura a Aragvi ve východní Gruzii. Kdysi tudy měla vést jedna z větví Hedvábné stezky. Obchod a projíždějící karavany přinášely prosperitu a metropole tak narostla až do velikosti 100 tisíc obyvatel. Tyhle časy jsou už dávno pryč, Mccheta je ale pořád domovem možná nejvýznamnější gruzínské památky.Všechny díly podcastu Zápisník zahraničních zpravodajů můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

What does it take to build a fiercely loyal customer base in the competitive casual dining world? Newton Hoang, VP, Head of Marketing for Kura Sushi, pulls back the curtain on their winning formula. In this episode, explore Kura Sushi's deep-rooted commitment to its customers, delivering a unique and interactive dining experience unlike any other. Learn how understanding customer demographics and thoughtful representation fuels their impactful marketing. We also delve into the fun – how Kura Sushi gamifies the meal with exciting prizes – and the accessible, making exceptional food available to all without breaking the bank. Tune in to hear how Kura Sushi is redefining value and connection.

On today's show, we chat with Melody Noel!For Melody Noel, music is a life force. Born into a family of mariachis spanning across seven generations — with the earliest musician dating back to the 1870s — Melody forged her own path as the first to create music outside the Mexican folk genre.  Melody began her journey in pop music as a member of teen girl group Runway MMC. This experience opened her eyes to the American music scene, working with the likes of Grammy nominated Alex Cantrall (“Leave (Get Out)” by JoJo) and Brandon Howard (“I Ain't Gotta Tell You” by Ne-Yo) for Runway MMC's debut EP “Forever Yours” (2008).  Melody pursued higher education at NYU's Clive Davis School of Recorded Music, graduating in 2014.  Her class project, an EP titled “The Living Room Sessions,” sparked the interest of music publisher Imagem Music; they signed her soon after in 2012.She continued her path as a songsmith in Los Angeles, toplining for songs such as “IDon't Wanna Love You” (Casablanca Records/UMG) by Prince Fox, “In My Head (feat.Georgia Ku)” (Mad Decent) by Party Favor, and “Paper Roses” (Spinnin' Records) by Kura.  In 2016, she co-wrote the single “Love Make the World Go Round” recorded by Jennifer Lopez and Lin Manuel Miranda. Released exclusively on iTunes, all proceeds were donated to those affected by the Pulse nightclub shooting in Orlando, FL. The song peaked at no. 72 on the US Billboard Hot 100 and no. 9 on the Digital Songs chart. After feeling the pull to write songs for something bigger than herself, Melody pivoted to the Christian music genre, establishing Influence Music in 2017. In 2018, Melody led the worship collective in creating iTunes no. 1 and Billboard no. 2 album “Touching Heaven.” Melody's single “Mistakes” made it on Billboard's Christian Airplay chart for 20weeks. She continues writing and performing songs that are utilized by churches globally.  To date, Melody's songs have been streamed 228 million times across DSPs. Whether writing music for pop icons, film and television or for local congregants, the banner Melody carries over it all is "Soli Deo gloria,” meaning “Glory to God alone.With the release of “Back to Praise” via Influence Music (distr. via Capitol Christian Music Group), Melody is stepping out in faith to accomplish such a mission. This EP consists of five pop-infused worship songs that remind believers that no matter what life brings, God is good, and our response is to keep coming “Back to Praise.” melodynoelmusic.com@melodynoelmusicchristianmusicguys.com@christianmusicguys

Baadhi ya wanachama wa jumuiya yawa Afrika wanao ishi Melbourne, Victoria wame kuwa waki kabiliana na wakati mgumu katika kipindi cha kampeni za uchaguzi wa jimbo na shirikisho.

On election day the Australian Electoral Commission anticipates one million voters to pass through their voting centres every hour. Voting is compulsory for everyone on the electoral roll, so all Australians should familiarise themselves with the voting process before election day. - Siku ya uchaguzi Tume ya Uchaguzi ya Australia inatarajia wapiga kura milioni moja, watapita katika vituo vya kupiga kura kila saa moja. Ni lazima kupiga kura kwa kila mtu ambaye yuko katika sajili yakupiga kura, kwa hiyo wa Australia wote wana stahili jifahamisha na mchakato wa kupiga kura kabla ya siku ya kupiga kura.

Pavasaris ieskrienas, un ieskrienas arī aktīvisti, kas par savu hobiju un sportu izvēlējušies skriešanu. Tuvojas Rīgas maratons, kurā piedalīsies arī Edgars Šumskis, gargabalnieks, kurš nesen pārstāvēja Latviju pirmajā Eiropas skriešanas čempionātā, veicot pusmaratona distanci. Podkāstā "Ārpus kadra" viņš dalījās padomos jaunajiem skrējējiem, paskaidroja šīs disciplīnas nianses un neslēpa savu pieredzi. Sportacentrs.com podkāsts Ārpus kadra – katru trešdienas vakaru kanālā TV4, portālā Sportacentrs.com un visās populārākajās audio straumēšanas platformās. Ārpus kadra 2025. gadā uz priekšu dzen oficiālais KTM un MERIDA velosipēdu pārstāvis Latvijā AstraVelo, bet podkāstam veldzi nodrošina Akvile minerālūdens

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there's a lot they don't know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they'd known about when they were starting out in science. This week, a Māori marine scientist is combining indigenous knowledge with marine science to save the oceans that are so integral to her heritage.Growing up in 1970s New Zealand, Kura-Paul Burke faced stigma due to her Māori roots. But, after finding herself studying marine science as an adult, Kura leaned on her heritage to take on a problem where many had already failed: restoring a lost population of precious, green-lipped mussels. Discover how Māori ancestresses, tribal elders and centuries-old knowledge inspired the ingenious methods of Aotearoa's first female Māori professor of marine science.Presenters: Ella Hubber and Julia Ravey Guest Speaker: Dr Kura Paul-Burke Producers: Ella Hubber and Julia Ravey Assistant Producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire(Image: Dr Kura Paul-Burke. Credit: Dr Kura Paul-Burke)

Mokslininkai sugriovė mitą, kad cigarečių alternatyvos nekenkia sveikatai. Nors tradicinės cigaretės išlieka dažniausias rūkymo pasirinkimas, per pastaruosius du dešimtmečius atsirado ir išpopuliarėjo kitos alternatyvos, tokios kaip elektroninės cigaretės ir kaitinamasis tabakas. Nors buvo manoma, kad tai mažiau kenksmingas rūkymo būdas, moksliniai tyrimai rodo, kad bet koks rūkymas yra žalingas. Pokalbis su Vilniaus universiteto Medicinos fakulteto profesore Natalija Istomina.Portugalijoje, Lisabonoje ir Porte, atveriamos pirmosios lituanistinės mokyklos,įkurtos siekiant saugoti lietuvių kalbą, puoselėti tradicijas, tautinę tapatybę ir kurti jaunosios kartos ryšį su Lietuva. Nuo šių metų rugsėjo prie pamokų nuotoliniu būdu taip pat prisijungs Brazilijos lietuviai.Balandžio 13 d. Japonijoje, Osakos mieste, startuoja pasaulinė paroda „EXPO 2025“, kurioje dalyvaus daugiau nei 160 šalių ir tarptautinių organizacijų. Parodos lankytojai, kurių tikimasi sulaukti net 28 mln., turės unikalią galimybę mėgautis Lietuvą reprezentuojančiu išskirtiniu patiekalu – šaltibarščiais. Oficialaus „EXPO 2025“ parodos restorano „Kura sushi“ virėjas atkūrė lietuvišką patiekalą pagal autentišką receptą ir adaptavo jį japoniškam gomuriui.Šalia Kauno, Kačerginėje, gyvenanti Rodica Morari (RodIka MorAri) į Lietuvą prieš kelerius metus atvyko iš Moldovos ir mūsų šalyje atsiskleidė kaip menininkė. Taip pat pramoko lietuvių kalbos. Neseniai dailininkė Kačerginėje atidarė ir savo naują kūrybos erdvę. Ten užsuko kolega Andrius Baranovas.

It's a Thursday in Auckland, and you know what that means: Autumn is upon us. Or maybe Spring. Tim is pioneering a new way of assigning seasons to days of the week, and Guy has some opinions. Kura Forrester, fresh off the release of Bryn & Ku's Singles Club, is gearing up for a living arrangement at MICF that has genuine sitcom potential, which the boys relate to the only way they know how: by trying to figure out which one is the Samantha of the group.Get episodes early and in video on our Substack! Hosted on Acast. See acast.com/privacy for more information.

Wa Australia milioni kumi na nane wame sajiliwa kupiga kura katika uchaguzi wa shirikisho mwezi ujao.

The Police Deputy Commissioner says staff are pleasantly surprised at the effectiveness of banning gang patches. Rival gang tensions in Gisborne mean officers have just been given extra powers to search and impound vehicles and seize weapons, following eight incidents in a week. Tania Kura told Mike Hosking the gang patch ban has been really good for them. She says it's brought more control to the situation, with staff admitting it's probably gone better than they thought. However, Kura says this doesn't mean they can rest on their laurels either. LISTEN ABOVE See omnystudio.com/listener for privacy information.

With another federal election due this year, there are steps you will need to take before casting your vote for the first time. Plenty of resources are available to help you enrol to vote and have your say in shaping our nation. - Uchaguzi mwingine wa shirikisho ukitarajiwa mwaka huu, kuna hatua utahitaji chukua kabla yakupiga kura yako kwa mara ya kwanza. Kuna rasilimali nyingi zaku kusaidia kujisajili kupiga kura na kutoa maoni yako katika mustakabali wa nchi yetu.

Na początek taka dana statystyczna: na jednego Polaka przypada półtorej kury, a na jednego obywatela USA kura i ćwierć kury. Amerykanie chyba starają się nadrobić tę statystykę, tym bardzie, że teraz płaca pawie 10 dolców za tuzin jajek. Amerykanie postanowili wziąć jajka we własne ręce i pojawił się nowy trend: wypożyczalnie kur. Można wynająć sobie kurę na kilka miesięcy i cieszyć się świeżymi jajkami prosto spod, powiedzmy metaforycznie dzioba. Firmy takie jak Rent The Chicken, po polsku rent a kura, czy pożycz se kurę oferują sześciomiesięczny wynajem kur niosek

Akili ya bandia ni teknolojia mpya ambayo watu wanajaribu kuelewa. Watafiti waki jumuishwa.

Uchaguzi mwingine wa shirikisho unatarajiwa kufanywa mwaka huu, kuna hatua unastahili chukua kabla yakupiga kura yako kwa mara ya kwanza.

Experts say AI could have significant impacts on democracy and trust. - Watalaam wanasema AI inaweza kuwa na madhara makubwa kwa demokrasia na uaminifu.

Robert Kluger, Chief Development Officer at Kura Sushi, joins Matt to share the story behind Kura Sushi, a revolving sushi bar restaurant originating from Japan. He discusses how Kura Sushi leverages technology, such as revolving sushi belts and drink robots, to enhance labor efficiency and create unforgettable customer experiences. Robert, who has held leadership roles at industry giants like Panda Express, Panera Bread, and Blaze Pizza, also shares his personal expertise in scaling restaurant brands and selecting prime real estate in today's competitive market.About Robert KlugerMr. Kluger has served as Chief Development Officer of Kura Sushi USA since May 2020. Most recently, Mr. Kluger served for four years as Senior Vice President of Development and Vice President of Real Estate for Blaze Pizza, LLC, a fast casual artisan pizza brand with approximately 340 units worldwide. Blaze Pizza added over 200 franchise-operated restaurants during Mr. Kluger's tenure. Prior to Blaze Pizza, he spend 6 years at Panera Bread, the largest bakery-café concept in the U.S. also with a presence in Canada, as their Senior Development Manager. During his first 3 years at Panera Bread, Mr. Kluger rapidly grew Panera Bread's footprint in Southern California opening both company and franchise operated bakery-cafés, then in his last 3 years was charged with leading franchise development nationwide. During Mr. Kluger's tenure, Panera Bread opened approximately 800 bakery-cafes. Previously, he spent 12 years at Panda Restaurant Group and held various roles including Vice President of Real Estate. Panda Restaurant Group, parent to Panda Express, Panda Inn and Hibachi San is the largest quick service Chinese restaurant chain in the U.S. and internationally. Mr. Kluger was charged with growing Panda Express in traditional and non-traditional venues across the United States. Panda Express opened approximately 1,300 restaurants during Mr. Kluger's tenure. Mr. Kluger started his career in field operations and a corporate capital planner and financial analyst at The Vons Companies Inc., at the time the largest grocery chain in Southern California with over 300 units and $5 billion in total sales. About Kura SushiSince the opening of its first restaurant in 1977, our parent company, Kura Corporation and Kura Sushi USA have grown to over 600 locations across Japan, Taiwan, and the United States. As pioneers of the “revolving sushi” concept, the Kura family of companies have improved upon the idea and developed innovative systems that combine advanced technology, premium ingredients, and affordable prices to create a unique revolving sushi dining experience.We pay particular attention to the taste, sourcing, and preparation of all of our dishes. Nothing is more important to sushi than the rice and the vinegar. We evaluated over 100 varieties of rice before selecting the perfect one to mix with our secret vinegar recipe. Also, our philosophy of “muten” or “nothing added” is an ongoing promise that our food is prepared using natural ingredients with no additives or artificial preservatives.

Following the success of Fonk Radio and Front Of House Radio, Dannic returns with a fresh episode of Fonk Monthly Mix—his signature monthly show packed with high-energy beats and exclusive selections. Expect a handpicked blend of tracks from his live sets, new originals, remixes, the latest from Fonk Recordings, and music from rising talents. Plus, you'll hear exclusive mashups, bootlegs, edits, and more! Get ready to turn up the volume and bring the Fonk! Fonk Monthly Mix 014 – Tracklist 1. Nairi - Musica   2. Dannic & Roc Dubloc - PUT 'M UP (SO MUCH IN LOVE MASHUP)   3. Javi Torres, KALMA - Buen Flow (Extended Mix)   4. Bingo Players & Oomloud - Like This Like That (Extended Mix) [Hysteria Records]   5. ManyFew x A-Tribe - Feelin' (Extended Mix) [MLAB]   6. Don Diablo - The Way I Are (Extended Mix)   7. Dubvision - ACID DREAM BABY Bootleg 8. Dannic - Push Me (Extended Mix)   9. Nari & Milani - Atom (JareB34R Edit)   10. Language Seanyy 2025 Remix   11. Dannic & Kristianex vs. Swedish House Mafia - Everything vs. Greyhound vs. Survivors (Tyo & Tro MashUp)   12. Vion Konger - Palante (Extended Mix)   13. NoBoundariez - ID 14. Vluarr & ONEDUO - Senses (Now We Go) (Extended Mix)   15. KURA feat Niko - Talking Dirty (Extended Mix)   16. Tujamo - Slip And Slide (feat Alimish) (Extended Mix)   17. Tommy Jayden - Stupid (Extended Mix)   18. NLW - Free Your Mind (Extended Mix) [Wall Recordings]   19. Raffa Guido - Famax (Dannic Bootleg)   20. Tiesto x Lucas & Steve - Free Your Mind   21. Dannic & Ryos - The Underground (Extended Mix)   22. Justin Mylo & Ryos feat. Alessia Labate - Out Of Time (Extended Mix)  

01. R3HAB & Skytech - Hypnotising [PREMIERE]  02. SIDEPIECE feat. Barney Bones - Ménage à Trois  03. Chris Lake x Abel Balder - Ease My Mind  04. Nosi - So Good  05. Steve Angello & Modern Tales - Darkness In Me [TRACK OF THE WEEK]  06. R3HAB, Michael Patrick Kelly, Shaggy - Rebellion  07. A7S x Paul Oakenfold - Lose It  08. Chapter & Verse - Can't Stop  09. Genesi, Meduza - Take It  10. FAST BOY - Loveless [CYB3RSTAR]  11. Anyma, Argy, Son Of Son - Voices In My Head  12. Luis Torres & Corporate Slackrs - Beat Rock  13. Alok & Kylie - last night i dreamt i fell in love  14. Nicky Romero x David Guetta - Shout  15. Cat Dealers, Felguk, Kyra Mastro - Otherside  16. HAÌWK, PÃP CULTUR - The Illest  17. KURA feat. Niko - Talking Dirty  18. Dimitri Vegas, Steve Aoki, Ann Lee, Sound Of Legend – 2 Times (REESE Remix)  

Turn up your sound systems - it's Blasterjaxx with Maxximize On Air! Have a great weekend, and keep it Maxximized! 01 Cat Dealers, Felguk, Kyra Mastro – Otherside 02 KURA feat Niko - Talking Dirty 03 Genesi, Meduza (Feat. Aya Anne) - Freak 04 MISS DRE, Dansyn - Light The Fire 05 Teddy Swims - Bad Dreams (Jay Hardway Remix) 06 The Weeknd - São Paulo (Ape Rave Club Bootleg) 07 Human Resource - Dominator (Just_us Extended Remix) 08 NERVO x Tigerlily - Mickey 09 DJ PEACH, JEEN SEIGO & Kohey - Radiant Sky 10 Ernesto vs. Bastian - Thrill 11 SAMDMA - Connection 12 01 Sacha Harland Ft. Bina - The City 13 Dark Monks - Insane (Hardwell Remix) 14 Ben Gold & SUPERSTRINGS - The Whip 15 Mandy - The Flow 16 Vision X & EDL - Left 2 Right 17 Armin van Buuren & Ben Hemsley feat. Lucy Pullin - Is It Beautiful 18 1991 & Subsonic & IVD - Castles In The Sky

Turn up your sound systems - it's Blasterjaxx with Maxximize On Air! Have a great weekend, and keep it Maxximized! 01 Cat Dealers, Felguk, Kyra Mastro – Otherside 02 KURA feat Niko - Talking Dirty 03 Genesi, Meduza (Feat. Aya Anne) - Freak 04 MISS DRE, Dansyn - Light The Fire 05 Teddy Swims - Bad Dreams (Jay Hardway Remix) 06 The Weeknd - São Paulo (Ape Rave Club Bootleg) 07 Human Resource - Dominator (Just_us Extended Remix) 08 NERVO x Tigerlily - Mickey 09 DJ PEACH, JEEN SEIGO & Kohey - Radiant Sky 10 Ernesto vs. Bastian - Thrill 11 SAMDMA - Connection 12 01 Sacha Harland Ft. Bina - The City 13 Dark Monks - Insane (Hardwell Remix) 14 Ben Gold & SUPERSTRINGS - The Whip 15 Mandy - The Flow 16 Vision X & EDL - Left 2 Right 17 Armin van Buuren & Ben Hemsley feat. Lucy Pullin - Is It Beautiful 18 1991 & Subsonic & IVD - Castles In The Sky

Rei and Eric are acheiving things, Kura is crafting, and Nick says that all these rewards are not enough.

Anyikööl tɛn ke jɔk Makuach Maker Maluach thuëc kura Baɛketball ciök thin.

I veckans avsnitt poddar Janni och Mickis från exotiska Curaçao och delar med sig av sina första intryck av ön – eller är det "Kuraçao"? De pratar om de intensiva dagarna med plåtningar och filmningar, där de fått jobba med ett otroligt proffsigt crew som tar hand om varje detalj. Dessutom berättar de om flygresan som bjöd på allt från turbulens och en ofrivillig "random check" till mötet med en mycket speciell medpassagerare. Välkommen att hänga med bakom kulisserna på resan! Produceras av More Than Words Hosted on Acast. See acast.com/privacy for more information.

So Bhaktivinod Ṭhākur had come to see the Siddha Mahātmā and received many important instructions from him. Around those instructions for worshiping Lord Caitanya Mahāprabhu in the age of Kali Yuga, he passed them on to his followers and disciples. Therefore, this particular place is our home. Home is where the heart is. The mood of bhakti that we've received through our disciplic succession, and continue to receive today, comes from the great souls, and very specifically, Jagannāth Dās Bābājī Mahārāj, who gave us this strong emphasis on worshiping Nityānanda and Gaurāṅga in the Age of Kali. In order to come to the perfection of life, not to approach Kṛṣṇa directly, but to go through the mercy of Lord Caitanya. (excerpt from the talk) ------------------------------------------------------------ To connect with His Grace Vaiśeṣika Dāsa, please visit https://www.fanthespark.com/next-steps/ask-vaisesika-dasa/ ------------------------------------------------------------ Add to your wisdom literature collection: https://iskconsv.com/book-store/ https://www.bbtacademic.com/books/ https://thefourquestionsbook.com/ ------------------------------------------------------------ Join us live on Facebook: https://www.facebook.com/FanTheSpark/ Podcasts: https://podcasts.apple.com/us/podcast/sound-bhakti/id1132423868 For the latest videos, subscribe https://www.youtube.com/@FanTheSpark For the latest in SoundCloud: https://soundcloud.com/fan-the-spark ------------------------------------------------------------ #vaisesikaprabhu #vaisesikadasa #vaisesikaprabhulectures #spirituality #bhaktiyoga #krishna #spiritualpurposeoflife #krishnaspirituality #spiritualusachannel #whybhaktiisimportant #whyspiritualityisimportant #vaisesika #spiritualconnection #thepowerofspiritualstudy #selfrealization #spirituallectures #spiritualstudy #spiritualexperience #spiritualpurposeoflife #spiritualquestions #spiritualquestionsanswered #trendingspiritualtopics #fanthespark #spiritualpowerofmeditation #spiritualgrowthlessons #secretsofspirituality #spiritualteachersonyoutube #spiritualhabits #spiritualclarity #bhagavadgita #srimadbhagavatam #spiritualbeings #kttvg #keepthetranscendentalvibrationgoing #spiritualpurpose

2024 was a special year for Carnival and the Japan-New Orleans connection! Lafcadio Hearn's life & works inspired the theme for Rex Parade 2024: "The Two Worlds of Lafcadio Hearn - New Orleans & Japan". But why Hearn? What went into the float design? What other ways has Hearn left a lasting impact on both New Orleans & Japan? Find out today with a super-sized special Mardi Gras bonus episode, featuring insights from Rex historian/archivist Will French & historian/archivist emeritus Dr. Stephen Hales, Royal Artists float designer/artistic director Caroline Thomas, Lafcadio Hearn's great grandson Bon Koizumi,  legendary chef John Folse, Captain of the Krewe of Lafcadio John Kelly, JSNO's resident Lafcadio Hearn expert Matthew Smith, and even the Mayor of Matsue Akihito Uesada! Get ready for Mardi Gras 2025 by reflecting on this unique connection between New Orleans & Japan!------ About the Krewe ------The Krewe of Japan Podcast is a weekly episodic podcast sponsored by the Japan Society of New Orleans. Check them out every Friday afternoon around noon CST on Apple, Google, Spotify, Amazon, Stitcher, or wherever you get your podcasts.  Want to share your experiences with the Krewe? Or perhaps you have ideas for episodes, feedback, comments, or questions? Let the Krewe know by e-mail at kreweofjapanpodcast@gmail.com or on social media (Twitter: @kreweofjapan, Instagram: @kreweofjapanpodcast, Facebook: Krewe of Japan Podcast Page, TikTok: @kreweofjapanpodcast, LinkedIn: Krewe of Japan LinkedIn Page, Blue Sky Social: @kreweofjapan.bsky.social, & the Krewe of Japan Youtube Channel). Until next time, enjoy!------ Music Credits ------Background music provided by: Royalty Free Music by Giorgio Di Campo for Free Sound Music http://freesoundmusic.eu FreeSoundMusic on Youtube  Link to Original Sound Clip------ Audio Clip Credits ------Thanks to Dominic Massa & everyone at WYES for allowing us to use some of the audio from the below Rex Clips:Segment about Royal Artist & Float DesignFull 2024 Rex Ball Coverage (Krewe of Lafcadio/Nicholls State segment)Thanks to Matsue City Hall & Mayor Akihito Uesada for their video message below:Message from Matsue Mayor Akihito Uesada------ Support the Krewe! Offer Links for Affiliates ------Use the referral links below & our promo code from the episode!Support your favorite NFL Team AND podcast! Shop NFLShop to gear up for football season!Zencastr Offer Link - Use my special link to save 30% off your 1st month of any Zencastr paid plan! ------ Past KOJ Hearn/Matsue/History Episodes ------Foreign-Born Samurai: William Adams ft. Nathan Ledbetter (Guest Host, Dr. Samantha Perez) (S5E17)Foreign-Born Samurai: Yasuke ft. Nathan Ledbetter (Guest Host, Dr. Samantha Perez) (S5E16)Explore Matsue ft. Nicholas McCullough (S4E19)Jokichi Takamine: The Earliest Bridge Between New Orleans & Japan ft. Stephen Lyman (S4E13)The Life & Legacy of Lafcadio Hearn ft. Bon & Shoko Koizumi (S1E9)Matsue & New Orleans: Sister Cities ft. Dr. Samantha Perez (S1E2)------ Links about Rex ------2024 Rex Parade/Float PDF with Full DesignsCaroline Thomas's Website------ JSNO Upcoming Events ------JSNO Event CalendarJoin JSNO Today!

Ayahuasca isn't right for everyone, but if you have decided to dive down this psychedelic rabbit hole, hopefully you have already discovered the necessity to support, respect, and listen to the indigenous cultures that have had intergenerational relationships with this powerful plant medicine. That necessity is the catalyst for inviting indigenous rights activist and psychedelic leader, Dr. Glauber Loures de Assis, as a guest on this episode of Open Deeply. Glauber is the founder and president of Céu da Divina Estrela, a legal and tax-exempt Santo Daime ayahuasca church in Brazil, a Ph.D. in sociology, and has led more than 500 ceremonies in Brazil, Europe and the United States. He points out that, “While some investors in the psychedelic sector considered the flooding at Burning Man to be their most dangerous experience in many years, communities in the Amazon are fighting daily for their lives amid both fire and flood, state-sponsored famine and the threat of death from illegal miners.” And yet we shouldn't be so short sighted to believe that this is a one-way relationship. If we listen, then we will discover that they can help us profoundly when we need it most. For instance, Glauber states, ““Indigenous contexts offer awareness beyond the psychotherapeutic, where illness and healing are social processes oriented within a collective experience.” Our culture founded on individualism knows little of that. He speaks beyond, psychedelics to kindelics and somadelics, all concepts that we are unfamiliar with, but shamans and indigenous cultures, like the Brazilian Yanomami know so well. Glauber teaches us about these concepts, expands our horizons, and even speaks on the Psychedelic Parenthood Community. Get ready to have your mind blown as we once again dare to Open Deeply. Glauber's Bio: Dr. Glauber Loures de Assis is a researcher of sacred plants and their traditions and a psychedelic dad. He has a Ph.D in sociology from the Federal University of Minas Gerais (UFMG). He is the author of numerous articles and book chapters, and the co-editor of the book Women and Psychedelics: Uncovering Invisible Voices (Synergetic Press). He has built his Santo Daime practice in dialogue with his local Brazilian ayahuasca community and with the blessings of Indigenous elders and activists in Brazil. He is also the co-founder of Jornadas de Kura, a plant medicine center in Brazil that promotes an alliance between the ceremonial use of sacred plants, public education on plant medicine and psychedelic science. He is father to 3 children and lives with his wife Jacqueline Rodrigues in Santa Luzia, Minas Gerais, Brazil.Glauber is driven by the desire to collectively co-create a plant medicine community in which all families are safe, welcome and integrated into the psychedelic field. A community in which diversity is embraced, children and elders are taken seriously, ancestral Indigenous traditions are honored, and where all kinds of families can coexist in solidarity. How to find Glauber: glauber@psychedelicparenthood.org IG: http://instagram.com/glauberloures How to find Sunny Megatron: Website: http://sunnymegatron.com Facebook http://facebook.com/sunnymegatron Twitter http://twitter.com/sunnymegatron Instagram http://instagram.com/sunnymegatron Tiktok https://www.tiktok.com/@sunnymegatron YouTube https://www.youtube.com/sunnymegatron American Sex Podcast https://open.spotify.com/show/2HroMhWJnyZbMSsOBKwBnk How to find Kate Loree: Website http://kateloree.com Instagram: http://instagram.com/opendeeplywithkateloree Tiktok: https://www.tiktok.com/@opendeeplywithkateloree Facebook: https://www.facebook.com/kateloreelmft Twitter http://twitter.com/kateloreelmft YouTube https://youtube.com/channel/UCSTFAqGYKW3sIUa0tKivbqQ Book referenced: The Falling Sky: Words of a Yanomami Shaman by Davi Kopenawa and Bruce Albert. Open Deeply podcast is not therapy or a replacement for therapy.

Bhaktivinoda Ṭhākura had this vision that everyone in the world could align with Lord Caitanya. Mahāprabhu's mission.Prabhupāda writes, "If one takes Lord Chaitanya Mahāprabhu as the universal guru and Lord Jagannāth as the Supreme Personality of Godhead, then one's path in life is complete." So Bhaktivinoda Ṭhākura saw this opportunity, and he also saw that people around the world, everywhere they're attracted to music and song. The most famous people and leaders of ideological movements in the world, even de facto, are musicians and poets. In the 1960s, it was Peter, Paul, and Mary, Joan Baez, and Bob Dylan, and others like that who would sing about their ideology. People would listen to the music, and even when they didn't intend to sing about something, people would say, "Oh, yeah, I know what that means," and they would become enlivened by it. So the Vaiṣṇavas come to town singing a song that resonates with the desire for us to go back home, back to Godhead through their songs and lyrics, which are perfect because they're informed by Kṛṣṇa within the heart of the Vaiṣṇava, and the haunting tunes that they compose, they urge us to wake up, just like the song "Jīve Jāgo." When we heard it the second time in that melancholy tune that Prabhupāda sings, it brings a sense of longing for a time when I can become free from the lower modes of nature and follow along with the Vaiṣṇavas, even if it says their dog, I'll just go with you guys. (excerpt from the talk) ------------------------------------------------------------ To connect with His Grace Vaiśeṣika Dāsa, please visit https://www.fanthespark.com/next-steps/ask-vaisesika-dasa/ ------------------------------------------------------------ Add to your wisdom literature collection: https://iskconsv.com/book-store/ https://www.bbtacademic.com/books/ https://thefourquestionsbook.com/ ------------------------------------------------------------ Join us live on Facebook: https://www.facebook.com/FanTheSpark/ Podcasts: https://podcasts.apple.com/us/podcast/sound-bhakti/id1132423868 For the latest videos, subscribe https://www.youtube.com/@FanTheSpark For the latest in SoundCloud: https://soundcloud.com/fan-the-spark ------------------------------------------------------------ #vaisesikaprabhu #vaisesikadasa #vaisesikaprabhulectures #spirituality #bhaktiyoga #krishna #spiritualpurposeoflife #krishnaspirituality #spiritualusachannel #whybhaktiisimportant #whyspiritualityisimportant #vaisesika #spiritualconnection #thepowerofspiritualstudy #selfrealization #spirituallectures #spiritualstudy #spiritualexperience #spiritualpurposeoflife #spiritualquestions #spiritualquestionsanswered #trendingspiritualtopics #fanthespark #spiritualpowerofmeditation #spiritualgrowthlessons #secretsofspirituality #spiritualteachersonyoutube #spiritualhabits #spiritualclarity #bhagavadgita #srimadbhagavatam #spiritualbeings #kttvg #keepthetranscendentalvibrationgoing #spiritualpurpose

At every moment, personal desires interfere without our realizing it. By taking shelter of the holy name, all these obstacles are removed, and we can obtain the fulfillment of our true desire, which is to dwell in the realm of pure love of Kṛṣṇa. In this world, no one is the special object of my affection, nor do I have the slightest hostility towards anyone. Whatever arrangements we make in this world are temporary. There is no need to waste time thinking about gain or loss here. The only thing anyone should strive for is the one supreme goal of life that is the treasure of love for Kṛṣṇa's lotus feet. So join together, all of you, and strive for this goal. Work together harmoniously with a single thing in mind and a single understanding. Working together with the same purpose, we will become qualified for the service of Rādhārāṇī, the original reservoir of love for Kṛṣṇa. May the stream of ideas promoted by Rūpa Gosvāmī and his followers ever flow. We must never try to be independent of his doctrine. May we never become indifferent or disinterested in the sacrifice of the holy name with its fire of seven flames. In the performance of saṅkīrtana if your single-minded devotion goes on increasing, then all your desires will be fulfilled and all your goals achieved. Take hold of the feet of the followers of Śrīla Rūpa Gosvāmī and follow them with exclusive commitment. Preach the message of Śrī Rūpa and Raghunātha fearlessly and with great enthusiasm. Through this preaching, you will attain all perfection. Through this preaching, you will attain all perfection. Through this preaching, you will attain all perfection from His Divine Grace Śrīla Bhaktisiddhānta Sarasvatī Ṭhākura. We are here on earth not to work as artisans for making big buildings with wood and stone, but to work only as messengers of the Divine Śrī Caitanya Deva. Śrīla Bhaktisiddhānta Sarasvatī Ṭhākura Ki Jai! (excerpt from the reading ) ------------------------------------------------------------ To connect with His Grace Vaiśeṣika Dāsa, please visit https://www.fanthespark.com/next-steps/ask-vaisesika-dasa/ ------------------------------------------------------------ Add to your wisdom literature collection: https://iskconsv.com/book-store/ https://www.bbtacademic.com/books/ https://thefourquestionsbook.com/ ------------------------------------------------------------ Join us live on Facebook: https://www.facebook.com/FanTheSpark/ Podcasts: https://podcasts.apple.com/us/podcast/sound-bhakti/id1132423868 For the latest videos, subscribe https://www.youtube.com/@FanTheSpark For the latest in SoundCloud: https://soundcloud.com/fan-the-spark ------------------------------------------------------------ #vaisesikaprabhu #vaisesikadasa #vaisesikaprabhulectures #spirituality #bhaktiyoga #krishna #spiritualpurposeoflife #krishnaspirituality #spiritualusachannel #whybhaktiisimportant #whyspiritualityisimportant #vaisesika #spiritualconnection #thepowerofspiritualstudy #selfrealization #spirituallectures #spiritualstudy #spiritualexperience #spiritualpurposeoflife #spiritualquestions #spiritualquestionsanswered #trendingspiritualtopics #fanthespark #spiritualpowerofmeditation #spiritualgrowthlessons #secretsofspirituality #spiritualteachersonyoutube #spiritualhabits #spiritualclarity #bhagavadgita #srimadbhagavatam #spiritualbeings #kttvg #keepthetranscendentalvibrationgoing #spiritualpurpose

Tracklist: 01. Mark Sixma, Orjan Nilsen & Push - Urban Shakedown (nilsix Remix) [Revealed] 02. Age Of Love vs Charlotte Witte & Enrico Sangiulian - The Age Of Love (Will Sparks Edit) 03. Andrew Rayel - The Abyss [Armind] 04. MIYUKI & Pablo Artigas - Y M C Acid [Find Your Harmony] 05. Alex di Stefano - Dark Factory [Outburst] 06. Marcel DK - Avantgarde (Cosmic Boys Remix) [Legend] 07. Hardwell & AVAO - I'm The Devil [Revealed] 08. Chukiess & Whackboi - Outta Control [SubHarmony] 09. Paul Denton - Acid Rave [Subculture] 10. Space 92 - Robot [Filth On Acid] 11. Mark Sherry & David Forbes - Black Sky [Outburst] 12. Corti Organ - Joker 2.0 [Find Your Harmony] 13. Maarten de Jong - Mystère [Armada Captivating] 14. Nifra - Hypnotize [VII] 15. Maddix feat. Sarah de Warren - Love Takes Over [EXTATIC] 16. D72 - The First Rebirth [Black Hole] 17. Hardwell - XTC [Revealed] 18. Space 92 - Polaris [Filth On Acid] 19. KURA & Giuseppe Ottaviani - Aria [Revealed] 20. Mauro Picotto - Verdi (Eftihios Remix) [Armada Captivating] 21. Maddix - I'm From Holland [EXTATIC] 22. David Forbes - 1994 [Dreamstate] 23. onTune - Panaceum [Subculture] 24. KASST - 2084 (Space 92 Remix) [Flyancce Records] 25. Brynx - Annihilation [SubHarmony] 26. One Off - Bass Line [SubHarmony] 27. Oskah - Good Old Rave 2 [Reaching Altitude] 28. RAM & Richard Durand pres Digital Culture vs Space Frog & Derb - Follow Me 2024 [Nocturnal Knights] 29. Key4050 - Feel Less [Subculture] 30. David Forbes - Techno Is My Only Drug [Armind] 31. Linka & Gregor Potter - Space [SubHarmony]  32. Taylor Torrence & Kristian Llov - To The Underground [CLUBWRK] 33. Felix - Dont You Want Me (KIKI Remix) [Armada] 34. Dimitri Vegas & Like Mike x Maddix x Da Hool feat. Kiki Solvej - Meet Her At The Love Parade [Smash The House]