Podcasts about P38

Riding Shotgun With Charlie #220 Matthias Quellenberg San Diego Firearms Academy   In 2022, I went to GunProm, hosted by San Diego Gun Owners. It was a huge event with over 750 attendees, the biggest 2A dinner I've attended. I was there with John Petrolino and we didn't really know many folks. We were put at the table with Matthais. We talked all night and exchanged contact info. The next day, he messaged me via Instagram and said he's seen the show, but didn't put it together after seeing me. The next week, Petrolinio messages me and says he's been messaging Matthias. I asked who and he replied “The German.” The name stuck.    In 2024, GRPC was held in San Diego, where he lives. We were able to film a show at the end of GRPC. Everyone was talking about “the wall” and I thought it was some sort of Pink Floyd tribute. Alas, it was the border wall. When he asked where we were driving, I replied “the wall.” We had to make sure we didn't cross into Mexico. I don't have a passport. He was packing.    Matthias grew up in Germany and served in the army. That was his first exposure to shooting and firearms. If it was a choice and an option for the citizens, he would have been a gun owner. But it's very elitist in Germany. The first gun he got to shoot was a Walther P1, the predecessor to the P38. He did boot camp, specialized training, then some office work, and ended up in the Ministry of Defense, similar to the Pentagon here. Then he became a boot camp instructor.    He met an American woman and they had a long distance relationship. Eventually, he made it to Boston. After they got married, he was able to get a green card and he applied for a License To Carry right away. They moved to California and settled in San Francisco. He found out there were only 2 carry permits issued in the city when he got there. In the same time, Fresno County issued over 6,000 permits.    Then life brought them to San Diego. Doing some research, he found out you needed to list your guns and serial numbers on your license and you could only have three guns on that carry license. He looked for an attorney who may want to pursue suing the state about this and ended up talking with the lawyers from the Peruta case. The lawyers thought they may be able to pair the cases, but it didn't fit their strategy.    Back in 2020 while he was Ubering, he would talk with his riders and gun owning came up. They were looking for guidance and opinions. Realizing that there could be a market, he became an NRA certified instructor and started San Diego Firearms School.    We got into talking about teaching gun classes. He teaches a couple classes a month. The next step for him is to get certified by the sheriff's department to be an instructor. In California, you have to take a short test to get the firearm safety certificate, which you need to purchase a firearm. Then you have to do a shooting qualification to be able to take the 16 hour course needed for the CCW permit.     Matthais won tickets to the GunProm back in 2022. That's when he started to see that there are so many more people involved in firearms and the bigger gun community in general. He's good friends with Desi Bergman (RSWC #217) and they both do lots for San Diego County Gun Owners. He even presented for one of their seminars.    I had a great time with Matthais. He's a great guy and he's out there busting his tail to make things happen. He's very active on Instagram, so follow him.  If you end up in San Diego, get an Uber driver with a German accent, and his good dog, Lucky,  there's a good chance it's Matthias!   Favorite quotes: “We don't have gun rights. Guns is not a thing in Germany.” “Within a week of me getting a greencard, I got my first gun and I applied for a License To Carry.”  “At the time, you can only have three guns on your license.” “So many people were asking me questions and looking for help and guidance.” San Diego Firearms School Website https://sandiegofirearmssc.wixsite.com/home   San Diego Firearms School Instagram https://www.instagram.com/sandiegofirearmsschool/   San Diego County Gun Owners https://sandiegocountygunowners.com/   Gun Owners Radio https://www.gunownersradio.com/ Second Amendment Foundation https://secure.anedot.com/saf/donate?sc=RidingShotgun    Citizens Committee for the Right to Keep and Bear Arms https://www.ccrkba.org/     Please support the Riding Shotgun With Charlie sponsors and supporters.    Dennis McCurdy Author, Speaker, Firewalker http://www.find-away.com/   Self Defense Radio Network http://sdrn.us/   Buy a Powertac Flashlight, use RSWC as the discount code and save 15% www.powertac.com/RSWC   SABRE Red Pepper Spray  https://lddy.no/1iq1n   Or listen on: iTunes/Apple podcasts https://podcasts.apple.com/us/podcast/riding-shotgun-with-charlie/id1275691565

慈濟的故事 壹 靜思 壹部曲 為什麼？1937年~1958年 「屯子腳」大地震 P38~42 一九三七‧清水後車巷 P44~47

In this week's episode, Martin's been to the auction, Steve hurts his back and the pair discuss timing chain failures for a US listener.The boys also debate the most reliable Range Rover in the world, and (unrelated) Martin's ambition to use a P38 for a 1990s-inspired Instagram account. Plus – how long have you owned your Land Rover?Also on the agenda is the many different types of Land Rover meets, and how getting involved with a club or group is easier now than ever.Feature of the Week and Product of the Week also star, from the current issue of Land Rover Monthly, and the guys chat about a cracking rustproofing guide in the magazine.Many thanks to the sponsors of this week's LRM Podcast, Adrian Flux Insurance.

On revient sur la question du règlement du P38. Entrevue avec Jean-François Plouffe, porte-parole d'Action Autonomie.Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Ben, Ted, and Brian catch up, then Ben talks with Chris C about his flight simulator use. The community shares opinions and suggestions, then Ted shares a clip from Chris C's recent video talking about having "jitters" after not flying for a while. Mentioned on the show: * Chris C, Flying Past 50, Rebuilding Confidence and Proficiency: https://www.youtube.com/watch?v=8a9eZQsle8Y * Flight sim discord thread: https://discord.com/channels/1016100180325564418/1257478939371114616 * Flight sim saves 5.5 hours of training: https://generalaviationnews.com/2024/05/29/study-confirms-flight-simulation-benefits-pilot-training/ * Full report: https://flightsimassociation.com/report * FlightChops, multi-engine IFR: https://www.youtube.com/watch?v=PSjDEQ5E6xQ * Freedom Aviation Network: https://www.freedomaviationnetwork.org/ * MPP EP37 - Looking for a flying purpose? Join the Freedom Aviation Network: https://podcasters.spotify.com/pod/show/midlifepilotpodcast/episodes/EP37---Looking-for-a-flying-purpose--Join-the-Freedom-Aviation-Network-e25oshp * ABY, Albany Georgia: https://www.airnav.com/airport/ABY * Eagles of America FBO, Albany Georgia: https://www.eaglesfbo.com/ * FlyVolar's scale P38 replica: https://www.flyvolar.com/ttp38 * Meigs Field in MSFS: https://fsnews.eu/simcident-report-massacre-at-meigs-field-the-ill-fated-fight-to-save-flight-sims-most-famous-airport/#:~:text=The%20airport%20served%20as%20Microsoft,Field%20and%20the%20downtown%20area.&text=Meigs%20made%20perfect%20sense%20as%20a%20default%20starting%20location. * MS Flight Simulator v1.0, which ran on the Osborne computer: https://www.mobygames.com/game/4003/microsoft-flight-simulator-v10/screenshots/pc-booter/779935/ * Erica Gilbert, Aerosafe, recurrent training in the TBM: https://www.patreon.com/posts/tbm-recurrent-106988865 * Riddle paper, "Transfer of Training from Flight Training Devices to Flight for Ab-Initio Pilots": https://commons.erau.edu/publication/149/ * "flight sims save 5.5 hours in training" survey: https://generalaviationnews.com/2024/05/29/study-confirms-flight-simulation-benefits-pilot-training/ * full report of the survey: https://flightsimassociation.com/report Flight sim add on links: * https://navigraph.com/ * https://www.simbrief.com/home/ * https://hifisimtech.com/asfs/ * https://www.sayintentions.ai/ * https://www.spadnext.com/home.html * https://gameglass.gg/ * https://www.siminnovations.com/ * https://www.pilotedge.net/ * https://www.trackir.com/ * https://gaming.tobii.com/product/eye-tracker-5/ * https://smoothtrack.app/

This month on our Refuel podcast, get ready for the ultimate showdown as we pit the P38 and L322 Range Rovers in a battle of Top Trumps! Featuring the two exquisite limited edition Holland and Holland models up for auction in the upcoming sale, on Saturday 11th May. View lot listings: https://www.historics.co.uk/buying This episode is bound to make your decision anything but straightforward. Which one would you choose? Let us know in the comments. You'll join our esteemed panel of auction specialists, including Dominic Lake, Mathew Priddy, and John Dutton, as they dissect every detail. Let the Range Rover Rumble begin!

Ever wonder how a modeler's passion stays ignited through every meticulous build? Grab your favorite modeling fluid and join Mike and  Kentucky Dave as they traverse the ins and outs of keeping our scale-modeling fires burning. From the details on new P38 book from Detail and Scale to the fascinating finds at HeritageCon, we cover it all. And while we're sharing a toast to our recent endeavors with a delightful black cherry hard cider and a smooth Bulleit bourbon, we'll delve into the importance of crystal-clear model instructions – a heartfelt shout-out to Flyhawk's BT-7 kit for leading by example.Scale modeling isn't just about the kits; it's about the journey and the community. In this episode, we'll get caught up with our Canadian friend Ian MacAulay at HeritageCon, where we're also joined by the insightful John Chung, who reveals the transformative experience of shifting from space shuttle builds to mastering the F-16. We'll reminisce about the camaraderie at HeritageCon, touch upon the trials of complex armor kit assembly, and ponder over the reflective moments post-completion. Our benchtop adventures are a testament to the joys and lessons learned from each project – something every modeler can resonate with.To cap it off, we'll share the latest from our benchtops: the completion of a Trumpeter LCM3 kit and the anticipation of fresh enhancements to the SAM model, all thanks to nifty CAD work. We're not just about the models, though; we're also about creative solutions and inspirations, like transforming an imperfect kit into a glossy die-cast toy replica. So, whether you're a seasoned builder or new to the craft, this episode is brimming with the kind of shared wisdom, expertise, and unexpected joys that can only come from true devotees of the hobby.Support the Show with any of these options!PatreonBuy Me a BeerPaypalThe Plastic Model Mojo Merchandise Store Mike's Modeling FluidDavid's Modeling FluidFlyhawk BT-7SQUADRON Adding to the stash since 1968Model Podcasts Please check out the other pods in the modelsphere!PMM Merchandise Store Support the show with PMM Merchandise!Model Paint Solutions Your source for Harder & Steenbeck Airbrushes and David Union Power ToolsDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Mike and Kentucky Dave thank each and everyone of you for participating on this journey with us. We are grateful for having you as listeners, and the community that has grown around Plastic Model Mojo makes it all worth while.

Car-Chum feels the long arm of the law in this episode.  Tony's joined by his regular Car-Chum and motoring journalist, Mike to tell the stories of cars and their drivers getting nicked!  From Bonnie and Clyde's letter to Henry Ford, through the-most-stolen Ford Capri, to modern-day dodgy data dealings, it's all here on this edition of Car-Chum.Support the show

On today's show with GunBroker.com, we're exploring the history of Walther Firearms. We start all the way back at the beginning with a nice history lesson on how Walther came to be. We discuss Walther's history in Germany, the firearms that Walther started with, and the opening of the United States location. We discuss the WA 2000, which is a super cool gun that Walther still gets questioned about today and why they still don't make it. It was a crazy-hard gun to make, but due to popularity in video games it has a pretty big cult following. We also talk about the Walther P38 and what it means for the history of Walther. Designed during WWII to replace the Luger P08 that was expensive to produce, the P38 skyrocketed into popularity. Arguably the most iconic gun Walther made besides the PPK, the P38 is easily recognizable in firearms history.  Closing out we talk about ergonomics and how Walther really kick started the importance of it when they launched the P99. Cody tells us about an amazing example of a P99, the Walther P99 La Chase Deluxe Special Edition. An absolute beautiful example of a P99, it was an awesome example of taking a polymer framed gun and upping the quality to the next level. The P99 is in the “Final Edition” phase now, this year will be the last year for the P99 so make sure to head over to GunBroker.com to pick one up today! The show launches every Thursday morning. Subscribe wherever you listen to podcasts. ### Learn more about your ad choices. Visit megaphone.fm/adchoices

On today's show with GunBroker.com, we're exploring the history of Walther Firearms. We start all the way back at the beginning with a nice history lesson on how Walther came to be. We discuss Walther's history in Germany, the firearms that Walther started with, and the opening of the United States location. We discuss the WA 2000, which is a super cool gun that Walther still gets questioned about today and why they still don't make it. It was a crazy-hard gun to make, but due to popularity in video games it has a pretty big cult following. We also talk about the Walther P38 and what it means for the history of Walther. Designed during WWII to replace the Luger P08 that was expensive to produce, the P38 skyrocketed into popularity. Arguably the most iconic gun Walther made besides the PPK, the P38 is easily recognizable in firearms history. Closing out we talk about ergonomics and how Walther really kick started the importance of it when they launched the P99. Cody tells us about an amazing example of a P99, the Walther P99 La Chase Deluxe Special Edition. An absolute beautiful example of a P99, it was an awesome example of taking a polymer framed gun and upping the quality to the next level. The P99 is in the “Final Edition” phase now, this year will be the last year for the P99 so make sure to head over to GunBroker.com to pick one up today!The show launches every Thursday morning. Subscribe wherever you listen to podcasts.###

Classic Jaguar's editor, Sam Skelton, joins Tony and Mike on this edition of the Car-Chum Podcast.  There's a bit of Jag stuff, but oh so much more besides.  Sam also reveals the most comfortable car on sale – and it is not what you would expect.  Go on:  take a guess.  And then take a listen to this edition of the ever-entertaining Car-Chum.  www.car-chum.com Support the show

Eric et Francois nous parlent du livre de francois sur l'histoire du Range Rover, anecdotes, catalogues, publicités, 240 pages et 2,2 kg de beau et gros papier. a commander avec de nombreux cadeaux sur www.alifeinrangerover.com ( page web de l'épisode)

Eric et Francois nous parlent du livre de francois sur l'histoire du Range Rover, anecdotes, catalogues, publicités, 240 pages et 2,2 kg de beau et gros papier. a commander avec de nombreux cadeaux sur www.alifeinrangerover.com ( page web de l'épisode)

Eric et Francois nous parlent du livre de francois sur l'histoire du Range Rover, anecdotes, catalogues, publicités, 240 pages et 2,2 kg de beau et gros papier. a commander avec de nombreux cadeaux sur www.alifeinrangerover.com ( page web de l'épisode)

In this portion of my interview with co-authors Racquel Ramsey and Tricia Aurand, Racqui reads a passage from Taking Flight: The Nadine Ramsey Story, in which her sister-in-law and WASP pilot, Nadine, purchases a P38. Thanks so much for listening! Stay up to date on book releases, author events, and Aviatrix Book Club discussion dates with the Literary Aviatrix Newsletter. Visit the Aviatrix Book Review website to find over 600 books featuring women in aviation in all genres for all ages. Become a Literary Aviatrix Patron and help amplify the voices of women in aviation. Follow me on social media, join the book club, and find all of the things on the Literary Aviatrix linkt.ree. Blue skies, happy reading, and happy listening!-Liz Booker

In part 2 of this series Miyanovich and Mags discuss: the venerable Garand and its realties, semi-auto v. bolt action in the European theater, the M1918A3 BAR, the German K98 Kurz, hating fucking Nazis, the Luger P08 pistol and its weird-cool toggle action, expensive P08 holsters, the so-so P38, and various other pieces from Jon's collection. 

Puntata andata in onda il 12/05/2022 negli studi di UniRadio Cesena. L'ennesimo dramma sociale delle istituzioni: c'è chi sminuisce le numerose molestie degli alpini sulle donne a Rimini, e c'è chi ferocemente attacca la libertà di fare musica con una gogna mediatica sulla P38, accusata di incitamento al terrorismo. Poi la leggenda del Tsuchinoko, il criptide che non è stato nemmeno catturato da Sampei. Si chiude con qualche riflessione sulle nostre paure nel futuro.

The value of Debswana's rough diamond sales over the course of 2021 registered P38.1bn, 60.7% higher than in 2020 (P23.7bn).  See omnystudio.com/listener for privacy information.

Notre invitée est Manon Francoeur. Elle nous livre un témoignage en tant que parent d'une enfant ayant des problèmes de santé mentale. Malgré les difficultés, il y a de l'aide disponible et de l'espoir. Aux segments Espresso, le sujet est : la thérapie par réalité virtuelle. Notre collaborateur Jean-François Plouffe, d'Action Autonomie, nous renseigne sur la garde en établissement (loi P38), surtout du point de vue de la personne concernée. Animateur, intervieweur et producteur: Yvan Bujold Preneur de son et chroniqueur aux segments Espresso: Pierre Laporte Site Web de Folie Douce: antenne.qc.ca © Copyright Antenne Communications Tous droits réservés

Franceschini, ci sei o ci fai? Da mesi si cercava chi fosse nel Palazzo il vero nemico di ristoratori e baristi, chi nell’ombra avesse tramato per addossare a loro il falso ruolo di untori. Altro che inutili allarmismi dei virologi o il silenzio assordante del ministro della Salute Roberto Speranza o, peggio ancora, le bugie dell’ex premier Giuseppe Conte. Stavolta il ministro della Cultura ha finalmente gettato la maschera e ha svelato il suo vero volto: è lui il “killer” dei pubblici esercizi. Con abilità da politico della Prima Repubblica, Dario Franceschini era sempre riuscito a nascondere la mano dopo aver tirato il sasso. Né qualcuno avrebbe mai pensato di fare l’antica prova del guanto di paraffina al Ministro che quale titolare “anche” del Turismo avrebbe dovuto essere il difensore d’ufficio del mondo dell’accoglienza, e invece usava una P38 contro chi serve spritz o spaghetti al pomodoro. È bastato che nel nuovo Governo il Turismo prendesse una sua autonoma identità, con tanto di ministro ad hoc, perché Franceschini si liberasse del fardello che lo angustiava da sempre: per lui bar e ristoranti dovrebbero stare chiusi per sempre, o quasi, perché sarebbero luoghi pericolosi. E la confessione non l’ha fatta in Chiesa o in un gruppo ristretto di amici. L’ha dichiarato pubblicamente in un’intervista al Corriere della sera dove sembra che l’unica cosa che lo rassereni sia essersi liberato di questa zavorra che non avrebbe mai gradito: «In questi mesi - ha dichiarato - abbiamo capito che i luoghi più pericolosi sono quelli dove ti togli la mascherina: ristoranti, bar, case private». Questa la follia di un Ministro che senza una sola prova scientifica, anzi contro i pareri dello stesso Comitato tecnico scientifico, spara a zero nel mucchio senza che nessuno (Draghi dove sei?) lo richiami all’ordine. Una semplice riga in cui si mettono alla berlina le imprese che più di tutte hanno pagato prezzi altissimi e spesso senza ragione, nonostante le prove di serietà e sicurezza date in più occasioni. Un’operazione che sul piano sociale e culturale si può tranquillamente definire da criminalità politica. Ma perché queste idiozie non le ha dette quand’era anche ministro del Turismo? Quindi per Franceschini nelle zone gialle chi frequenta un pubblico esercizio è come se entrasse nella tana del mostro Covid... Peccato che non ci siano stati focolai accertati nei ristoranti, mentre episodi di contagi a catena ci sono stati in occasione di spettacoli, che pure per Franceschini sono invece “sicuri”. «Nei teatri e nei cinema - ha aggiunto nella sua delirante dichiarazione - già nella riapertura estiva, c’erano misure di sicurezza molto rigide che si sono rivelate efficienti: mascherina, distanziamento, igienizzazione delle mani, sanificazione dei locali». Ma il ministro della Cultura ha forse alzato il gomito? Non lo sa che i protocolli di sicurezza dei ristoranti prevedono le stesse cose (mascherina, distanziamento, igienizzazione delle mani, sanificazione dei locali) e anche di più? Se poi pensiamo che in un teatro o in cinema nessuno può controllare se per circa due ore al buio l’utente indossa o meno la mascherina, c’è da chiedersi come faccia a sedere al governo. In un altro Paese, dopo simili dichiarazioni ci sarebbero state sollevazioni di piazza e magari le dimissioni immediate dell’improvvido ministro. Ma siamo in Italia e concludiamo con l’amaro commento del direttore generale di Fipe, Robeto Calugi, secondo cui «lascia stupiti leggere queste dichiarazioni, in particolare da un Ministro della Repubblica. Se si applicano i protocolli previsti dal Comitato tecnico scientifico i ristoranti sono luoghi assolutamente sicuri. Basta ricordare che furono riaperti il 18 di maggio e non ci risulta che a giugno, a luglio o ad agosto ci furono impennate dell’epidemia. La ristorazione e i pubblici esercizi in generale meritano certamente maggior rispetto, dopo un anno drammatico come questo». E forse ha ragione Calugi, meglio fermarsi qui. Scrivere di più sarebbe come sparare sulla Croce Rossa.

You all voted for it and we delivered... Well we did something. Tonight we talk shit! We introduce Luke, discuss his terrible cars and the sandwich collection he brought with him, Snaker talks about how nice Reg's P38 is to drive. The shit also includes pornhub, bikers vs lorry drivers and Reg shouts out Huw Thomas. Thanks to dranken.co.uk for importing Four Lokos! Go check them out if you want a 440ml 8.5% can of punch your nan!!! (This episode is not sponsored or endorsed by Dranken or Four Lokos, we bought this shit with our own god damn pennies)

This week we speak to Michael Vagnino about his early forging work and transition into folders and automatics with the help of D.B Fraley and Larry Chew. Vagnino also tells us about his recent team up with Patrick Mah of Prometheus Design Werx to form Terrain 365 and utilize cast Cobalt blades and Patrick's famous Invictus Design along with Michael's premiere P38 knife.

Nous recevons Myreille Bédard, qui nous présente son livre : vaincre la dépression et échange avec nous sur des enjeux de santé mentale. Au segment Espresso et à l'Espresso allongé avec Pierre et Yvan, il est question de la médecine vaudou. En début de deuxième partie de l’émission, notre collaborateur Jean-François Plouffe, d’Action Autonomie, nous parle du protocole de garde en santé mentale (loi P38). Animateur, intervieweur et producteur: Yvan Bujold Preneur de son et chroniqueur aux segments Espresso: Pierre Laporte Site Web de Folie Douce: antenne.qc.ca © Copyright Antenne Communications Tous droits réservés

Dr Carolyn Lam:                Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr Greg Hundley:             And I'm Dr Greg Hundley, associate editor for Circulation, from the Pauley Heart Center at VCU Health in Richmond, Virginia. Well, Carolyn, our feature article, this issue reminds us of the importance of the physical exam in patients with heart failure and reduced ejection fraction involving those that were enrolled in the PARADIGM-HF. Remember a trial of sacubitril/valsartan versus ACE inhibition in those with a reduced ejection fraction? Can't wait to hear more of the discussion of the importance of that physical exam. Carolyn, how about you talk about your first article? Dr Carolyn Lam:                I will because this first paper reports a novel ventricular tachycardia or VT ablation strategy guided by a voltage independent mapping display during sinus rhythm. Dr Greg Hundley:             Well, Carolyn, since many of us don't do VT ablations every day, how about a little background on this one first? Dr Carolyn Lam:                Substrate modification during sinus rhythm is actually the mainstay ablation strategy for scar related VT. With the recent trend being more extensive ablation, aimed to homogenize the entire scar region. These authors are led by Dr Tung from the University of Chicago Medicine Center for Arrhythmia Care, and colleagues. They had hypothesized that a greater understanding of the nature and characteristics of the scar would be most prone to reentry, may actually improve the precision and yield of ablation. Now, they had previously demonstrated that sites critical for reentrant VT localized to regions of activation slowing during sinus rhythm or so-called deceleration zones rather than regions with latest activation. In the current study, they aim to prospectively assess the outcomes of VT ablation guided primarily by targeting these deceleration zones identified by propagational analysis of ventricular activation during sinus rhythm. Dr Greg Hundley:             Interesting. What did they find, Carolyn? Dr Carolyn Lam:                They studied 120 patients with scar related VT who are prospectively enrolled in the U Chicago VT ablation registry between 2016 and 2018, who underwent 144 ablation procedures for scar related VT. They performed high density mapping during baseline rhythm and identified the deceleration zones which all localized to successful termination sites in 95% of cases. The median total radio frequency application duration was 29 minutes to target the deceleration zone, representing ablation of 18% of the low voltage area. At a mean of 12 months, 70% freedom from VT recurrence was achieved with an overall survival rate of 87%. A novel voltage independent high-density mapping display may further identify the functional substrate for VT during sinus rhythm and guide targeted ablation thus obviating the need for extensive radio frequency delivery. Dr Greg Hundley:             Fantastic, Carolyn.                                                 Well, my first paper is from Professor Mark Nicolls from Stanford University. It's entitled Phenotypically Silent Bone Morphogenic Protein Receptor 2 or Bmpr2 mutations, that predispose rats to inflammation induced pulmonary arterial hypertension by enhancing the risk for neointimal transformation. While being the most common inherited risk factor for pulmonary arterial hypertension, Bmpr2 germ line mutations only result in disease in 20% of mutation carriers. A finding that suggest a second hit is required to elicit vascular pathology. Transgenic mouse models of Bmpr2 mutations were developed in this study to better understand the relationship between these phenotypically silent gene mutations and the predisposition to pulmonary arterial hypertension. Dr Carolyn Lam:                Huh. What did they find Greg? Dr Greg Hundley:             In this new two hit model of disease, Bmpr2 mutant rats subjected to pulmonary inflammation, developed severe pulmonary arterial hypertension with vascular remodeling and the pulmonary arterial endothelial cell transformation that occurred did so in three phases. An initial apoptosis phase induced by exogenous LTB4. Second, a proliferative phase relying on P38 mediated noncanonical TGF-beta signaling. And then finally a terminal inflammatory phase in which pulmonary arterial endothelial cells utilized the canonical TGF-beta pathway, expressed mesenchymal markers and produced LTB4, IL6 and NF-kappa beta signaling molecules. The clinical implications include that in phenotypically silent Bmpr2, haploinsufficient individuals, a second hit of pulmonary inflammation may put them at risk for subsequently developing pulmonary arterial hypertension. And this lung inflammation while usually self-limited may cause durable and inflammatory vascular lesions in these genetically susceptible patients. Dr Carolyn Lam:                Wow, that is super interesting. Thanks Greg for that great summary.                                                 Well, my next paper really looks at the temporal trends in survival after pediatric in hospital cardiac arrest in the United States. This is from Dr Holmberg from Beth Israel Deaconess Medical Center and colleagues who performed an observational study of hospitalized pediatric patients who received CPR from January 2000 to December 2018 and were included in the Get With the Guidelines resuscitation registry. Dr Greg Hundley:             Carolyn, what did they find? Dr Carolyn Lam:                They found that survival has improved for pediatric events requiring CPR in the US with a 19% absolute increase in survival for in hospital pulseless cardiac arrests and a 9% absolute increase in survival for non-pulseless events between 2000 and 2018. However, survival from pulseless cardiac arrest appeared to have reached a plateau following 2010. The increase in survival over time is reassuring and perhaps provides some evidence for the progress of quality improvement efforts. However, given the plateau and survival following 2010, there is a continued need for clinical focus and new interventions to improve outcomes of pediatric in hospital cardiac arrests. And Greg, are you now going to tell us what's in the mailbag? Dr Greg Hundley:             Absolutely Carolyn. Professor Wei, from Harvard, provides a new perspective on using the restricted mean survival time difference as an alternative to the proportional hazards model and hazard ratios for analyzing risk in clinical cardiovascular studies. In another article, Eric Peterson from Duke provides a white paper discussing randomized clinical trials versus EMR extracted data to inform new therapies in cardiovascular disease. And he really reviews what are the issues we need to overcome using these EMR strategies? And on my mind piece from Dr Glenn Levine from Baylor, discusses the role of psychological wellbeing as it relates to cardiovascular disease. And then we have a large series of letters in this issue.                                                 First, Otmar Pfister and Kari Nytrøen, each have letters regarding high intensity interval training. Dong-Vu Nguyen, asked for several points of clarification regarding the utility of BNP assessments in syncope and whether other metrics incorporating clinical information could be useful. There's a corresponding response from Christian Müller from the PRICIPLE study with great discourse. And then finally an important research letter from Dr Rodés-Cabau in Quebec, evaluates the left atrial occlude or thrombus occurrence among eight centers in Canada and in this letter provides data that suggests thrombi can occur in those that have implanted left atrial occluders and raises considerations for anticoagulation of these patients. Great set of letters in this issue of the journal. Dr Carolyn Lam:                Absolutely Greg and thanks for sharing that. Let's go onto our feature discussion. Dr Greg Hundley:             You bet.                                                 Welcome everyone to discussion of our featured article and today we have Senthil Selvaraj from University of Pennsylvania and our own Mark Drazner, associate editor at Circulation from the University of Texas Southwestern and we're going to be discussing some very interesting results regarding the physical exam as they've been generated from the PARADIGM heart failure trial. And remember that's a prospective comparison of an Angiotensin Receptor-Neprilysin inhibitor with an angiotensin converting enzyme inhibitor to determine the impact of those two therapies on all-cause mortality and also morbidity in heart failure. Senthil, welcome to this discussion. We're very excited to have the opportunity to discuss your article and I wonder before we get started, could you tell us a little bit about the background and the hypothesis for why you wanted to perform the study and then afterwards tell us a little bit about the study population and the methods. Dr Senthil Selvaraj:          I think the impetus for this study torn out of the fact that we do the clinical exam so often, and I think like many cardiology clinicians in the community, we perform this so often, but we don't know what the actual impact is of performing the clinical exam. What I wanted to understand and the primary motivation was to really understand what the change in the physical exam meant in terms of subsequent prognosis. Does decreasing congestion actually relate to improved cardiovascular outcomes? I think this is an area that is hard to study by randomized controlled trials. In my opinion I think there is not so much equipoise in performing a trial of decongestion versus no decongestion. I think this is sort of one way that we can understand epidemiologic methods, whether lowering congestion improve outcomes.                                                 I had a number of other interesting analysis. I think the first is we've had a number of studies that have evaluated the physical exam, but I think that an updated analysis in a population receiving contemporary management was particularly important, particularly given the fact that the risk rad versus insignificantly in the past couple of decades essentially related to improvements in therapy. The second is we formed the physical exam in conjunction with a number of other additional forensic markers in the use of validated risk scores that to understand those and have utility above and beyond this. For instance, can I just check a natural aside and will that be doing a physical exam. And I think while that's easier, I don't know that that necessarily is the right thing to do. And that was another motivation. Dr Greg Hundley:             What was your overall study design and your study population? Dr Senthil Selvaraj:          The overall study design was to use the PARADIGM-HF cohort. And in our analysis, we did a time updated analysis, which is different than many other analyses previously done. That means that every single point that a patient goes into a clinical trial visit, we updated their physical exam, possible because the study investigators did perform an exam at each of these visits. And so what we did was we used the physical exam and number of signs of congestion as the time bearing covariate and looked at its relationship to outcomes, but also just as importantly why might think decreasing congestion or changing congestion has really stuck out as very important about to want to feel better. And I anything quantifying that relationship while it's intuitive I think is also very important. Dr Greg Hundley:             And just remind us who's in PARADIGM heart failure? Well what was the study population? And just very quickly the randomization arms? Dr Senthil Selvaraj:          PARADIGM-HF was a randomized controlled international multicenter trial of patients with heart failure ejection fraction which has been defined in this study as less than or equal to 40%, near two, three or four symptoms, elevated natriuretic peptides, depending on the trial compared an angiotensin converting enzyme inhibitor and Angiotensin Neprilysin inhibitor to control valsartan. Dr Greg Hundley:             Tell us what were your study results? And how did they pertain to the outcomes that were gathered in PARADIGM-HF? Dr Senthil Selvaraj:          We first divided our cohort based upon the total number of signs and as might imagine increasing congestion was associated with a number of adverse clinical features. We then looked at the association between the number of signs and the efficacy outcomes, which included a primary composite outcome of time to heart failure, hospitalization as well as cardiovascular mortality and then we individually looked at those as well as all-cause mortality. And as we show in our paper, there was really a striking relationship between time updated times of congestion as well as all of the efficacy adjusted for baseline natriuretic peptides which are available in all of our participants in PARADIGM-HF as well as MAGGIC risk score and New York Heart Association class to get at the question of whether improving congestion, where the relationship congestion above and beyond symptoms is still valid.                                                 The other thing that we did is because we only looked at natriuretic peptides at baseline is that we've formed a sub study where we evaluated, since you had natriuretic peptides during follow-up as well at the one month visit and eight month visit and compare the utility of signs of congestion and outcomes and you can still see that there was a significant relationship in this sub analysis. The participants would complete NP data. We further looked at relationship and congestion and quality of life and there is a significant relationship such that for every sign of congestion that you decrease, there is a five-point increase in KCCQ, the quality of life score which some have considered to be a clinically significant increase in times of congestion.                                                 We also looked at the relationship between the treatment arm and reduction of congestion as sacubitril/valsartan was associated with significant reduction in clinical congestion, which has mirrored its impact on natriuretic peptides as well. And finally to understand whether reducing congestion was actually associated with improved outcomes, we entered both the baseline congestion and change of congestion into models that looked at the relationship with outcomes and found that change of congestion was a very strong predictor of outcomes even after baseline congestion, which we interpreted to mean that reduction in congestion was a mutable factor, and that reducing congestion is actually associated with improved outcomes. Dr Greg Hundley:             Signs of congestion on the physical exam, you had JVD, peripheral edema, rales, and then an S3 and so you're adding those up and making a score. And so when one of those particular findings dropped off in terms of score, that's what you're indicating by change in congestion, is that correct? Dr Senthil Selvaraj:          That's really correct. We analyzed this in two methods. The first is a dichotomous presence of a physical exam science. As you said, the presence or absence of JVD, the presence or absence of a DMO rales and an aspirate. The investigators also graded two of those signs of congestion, which included a DMN rale that we formed a complimentary analysis where we created a sign score where we gave partial credits to gradations of the physical exam and we saw very similar outcomes as well. Dr Greg Hundley:             Mark Drazner at UT Southwestern has done a lot looking at the importance of our physical exam and assessing patients with heart failure. Mark, how do you feel the results of this study compare with previously published works? Dr Mark Drazner:             Thanks Greg. First, always a pleasure to join you on this and I do want to congratulate Dr Selvaraj and his team on this outstanding paper to generate considerable enthusiasm among the editorial team and reviewers I'd say. It's a really interesting study for several fold and you've heard a lot of the important methods by Dr Selvaraj already. I would just highlight there've been a number of previous studies that have looked at markers of congestion from physical exam and showed that they had prognostic utility, but a major question that has been addressed to me personally and I think in the field, does that add any independent information beyond just sending BMPR natriuretic peptide level measurement?                                                 And this analysis here as you've heard, one of the big advances was that they were able to adjust for natriuretic peptide levels and showed that the exam or the markers of congestion did add independent prognostic information. I think that's an important step forward, as is bringing the relevance again about the markers of congestion and prognostic utility to patients being receiving the most modern-day therapy including ARNI therapy, which is unparalleled opportunity because of the PARADIGM trial to look at that question. I think those two are really set this paper. I think this is going to be a standard, this is the standard for assessing prognostic utility congestion in heart failure by far in the literature in my opinion. Dr Greg Hundley:             What we're saying is that our following the patients and identifying these physical exam changes during an initiation of ARNI therapy can be really helpful in determining that particular patient's long-term prognosis. Coming back to both of you, maybe first Mark and then we'll come back to Senthil, what do you see is the next study in this field? Both in terms of new therapies in heart failure and the relationship of physical exam and then also perhaps just briefly some thoughts on ARNI therapy. Dr Mark Drazner:             I think this paper highlights the incredible importance of congestion in modern day therapy. And there are a number of other studies that looked at this recently, including there's an analysis of TOPCAT preserved heart failure showing again congestion being linked to adverse outcomes. I think that question is resolved that even in modern day therapy. The next step in my opinion is to understand why clinical congestion, the pathway from clinical congestion to adverse outcomes. What are the links? Can we target those links to try to interrupt that cycle? And what is the most effective way to achieve decongestion? We heard that now ARNI appears to be a mediator of decongestion and we need more work on that I think. I would say looking at the pathway from congestion to adverse outcomes and then what is the optimal way to decongest our patients. Dr Greg Hundley:             Very good. Senthil, do you have anything to add to that? Dr Senthil Selvaraj:          I think that's great. I completely agree with Dr Drazner on this. I think one question would be to understand truly as Dr Drazner said, the optimal way to decongest patients and so for instance, the way that we have traditionally done this is by increasing diuretic. There are a number of experimental and novel ways that we can decongest patients. I think one unanswered question actually is does increasing a diuretic potentially at the expense of activating the renin angiotensin aldosterone access, actually afford benefit if you decongest patients. It's an analysis that I think is ripe and timely and not been adequately addressed. I think that that would be one potential way to go. And the second is, I think as you mentioned in clinical trials, I think clinical congestion may not be an outcome, a pre-specified outcome of course. But I do think that it is an important outcome aside from just looking at decreases in other surrogate markers such as natriuretic peptides. It's easy to perform. It's collected on many investigator visits during these trials and therefore these are ripe analyses. Dr Greg Hundley:             Listeners, we look forward to speaking with you next week and have a great week. Dr Carolyn Lam:                This program is copyright American Heart Association 2019.  

1、小米盒子4发布支持4K HDR 249起售 2、联发科P38曝光对彪632 3、支持超线程的酷睿i3来了 4、格力手机2开启强买强卖模式 5、vivo xPlay 7或首发骁龙845

P38 by Ilyaspeaker

In this Episode, the team talks with WWII P-38 and P-51 Pilot Ira Comstock.  Ira was Born in 1924 in Van Buren, Arkansas.  He served in the US Air Corps, flying P-38's and P-51's for the Photo Reconnaissance Group. 

Le 31 juillet 1944, Antoine de Saint Exupery disparaît alors qu'il vole bord d'un P38 américain. Une longue enquête archéologique et historique permet de refaire le déroulement de cette journée.

Bouyakah sobre el soldel los coldos wave, here comes DJ Sainte Rita. DJ du bassin parisien depuis 2011, la jeunesse en toile de fond, pas mal de contributions à Radioclash et Ouïdire  (projet radiophonique lancé via Musiques Incongrues) dans le rétroviseur et une soirée au Chinois avec les légendaires Crash Course Science, il prend les commandes du Sandwich Triangle ce samedi soir 24 octobre. Une passion vaste pour les cultures synthétiques, l'homme prend un malin plaisir à mélanger la culture du ghetto cainRi type booty bass, ghetto house avec des influences européennes type post-punk, synth wave, EBM.... le tout passé dans la moulinette des gros classiques electro from Motor City.Il a l'habitude de se présenter devant les platines avec son ami Goupil Acnéique, mais ce samedi c'est seul qu'il chauffera le DJ booth de Campus Paris.Vous l'aurez compris, enfermez Tata Monique dans la placard et Mamie Jeannie sur la logia, barricadez la porte, sortez le P38, appelez votre dealer et déshabillez-vous, ghetto blaster reglé sur MAXIMUM pour un MasterBlaster mix by our guest DJ Sainte Rita !Info exclusive comme sur les sérieuses chaines d'informations à cravates uni-couleur 24/24 7to7, la bête sera avec le Vagina Dentata Crew le 11 décembre pour l'annuelle Frakkance party @Péniche Antipode, mais chut !!... PS: c'est toujours le Serendip festival les copains, et ce samedi Fourmi joue en live et Pétard Pétante Robert aka El Pil Poil Riposte ouvre le bal dès 23h00. Endroit magique, soirée immanquable avec Fah, Cachette à Branlette et Synapscape, le tout pour 7 euros. Merci qui ? Merci Serendip. TRACKLIST The Cure - ThreeThe Hacker - InIke Yard - NCRWeekend money ft Heems - YellowRyr Rye - Shake it to the ground (CVS mix)Aux 88 - Break it DownSeth Nemec - Count zeroGolden Teacher - LoveTuxedomoon - What is the use (Heinrich Mueller Technik Mix)Orphx - OutcastArabian Prince - Innovative life (DBS remix)Beek - NakedDeejay Punk-Roc - Far OutThe Hacker - The BrutalistLady Bee - Smile on your facePoison Clan- Shake Watcha Mama Gave YaSteril - Wipe your tears awayDJ Chip Dilla - CarbootiesSudanim - Pleasure FoodDJ Puncho - Get Down LowDJ Topcat - I Need Weed in my lifeDisko Baller Clique - Where U From?Slick Rogers - Drive me to a secret placeP1/E - RomanceDJ Deeon - Shake Dat ButtFeminnielli Noir - ExoticoBassman - Trans Europe ExpressPoladroid - UntitledOris Jay - Trippin (2010 Dub)Cosmetics - The CriesMuschi Muschi Magic Circus - SnakeConrad Schnitzler - ElektroklangGalaxian - Dosing the populationBjörk - Hunter (µ-ziq remix) - Fah - Mattel Mint FluteCeephax - Voyage of Excellox

Bouyakah sobre el soldel los coldos wave, here comes DJ Sainte Rita. DJ du bassin parisien depuis 2011, la jeunesse en toile de fond, pas mal de contributions à Radioclash et Ouïdire  (projet radiophonique lancé via Musiques Incongrues) dans le rétroviseur et une soirée au Chinois avec les légendaires Crash Course Science, il prend les commandes du Sandwich Triangle ce samedi soir 24 octobre.Une passion vaste pour les cultures synthétiques, l'homme prend un malin plaisir à mélanger la culture du ghetto cainRi type booty bass, ghetto house avec des influences européennes type post-punk, synth wave, EBM.... le tout passé dans la moulinette des gros classiques electro from Motor City.Il a l'habitude de se présenter devant les platines avec son ami Goupil Acnéique, mais ce samedi c'est seul qu'il chauffera le DJ booth de Campus Paris.Vous l'aurez compris, enfermez Tata Monique dans la placard et Mamie Jeannie sur la logia, barricadez la porte, sortez le P38, appelez votre dealer et déshabillez-vous, ghetto blaster reglé sur MAXIMUM pour un MasterBlaster mix by our guest DJ Sainte Rita !Info exclusive comme sur les sérieuses chaines d'informations à cravates uni-couleur 24/24 7to7, la bête sera avec le Vagina Dentata Crew le 11 décembre pour l'annuelle Frakkance party @Péniche Antipode, mais chut !!... PS: c'est toujours le Serendip festival les copains, et ce samedi Fourmi joue en live et Pétard Pétante Robert aka El Pil Poil Riposte ouvre le bal dès 23h00. Endroit magique, soirée immanquable avec Fah, Cachette à Branlette et Synapscape, le tout pour 7 euros. Merci qui ? Merci Serendip.TRACKLISTThe Cure - ThreeThe Hacker - InIke Yard - NCRWeekend money ft Heems - YellowRyr Rye - Shake it to the ground (CVS mix)Aux 88 - Break it DownSeth Nemec - Count zeroGolden Teacher - LoveTuxedomoon - What is the use (Heinrich Mueller Technik Mix)Orphx - OutcastArabian Prince - Innovative life (DBS remix)Beek - NakedDeejay Punk-Roc - Far OutThe Hacker - The BrutalistLady Bee - Smile on your facePoison Clan- Shake Watcha Mama Gave YaSteril - Wipe your tears awayDJ Chip Dilla - CarbootiesSudanim - Pleasure FoodDJ Puncho - Get Down LowDJ Topcat - I Need Weed in my lifeDisko Baller Clique - Where U From?Slick Rogers - Drive me to a secret placeP1/E - RomanceDJ Deeon - Shake Dat ButtFeminnielli Noir - ExoticoBassman - Trans Europe ExpressPoladroid - UntitledOris Jay - Trippin (2010 Dub)Cosmetics - The CriesMuschi Muschi Magic Circus - SnakeConrad Schnitzler - ElektroklangGalaxian - Dosing the populationBjörk - Hunter (µ-ziq remix)-Fah - Mattel Mint FluteCeephax - Voyage of Excellox

【小听童中英文双语故事】原始人斯坦利 Stanley2下集 P36. Stanley saw a field. “Does anybody mind if I live here?” he asked. 斯坦利看见田野。 “有人介意我住这里吗？”他问。 P37. “I don't mind if you don't snore,” said an animal who was going to sleep. “只要你不打呼噜，我就不介意。”正在睡觉的一只动物说。 P38. “I don't mind if you don't eat too much grass.” said an animal who was eating. “只要你不吃太多的草，我就不介意。”正在吃草的动物说。 P39. “I don't mind if you don't take up too much room.” said a very, very big animal. “只要你不占用太多的空间，我就不介意。”一个很大很大的动物说。 P40. Stanley made himeself at home. “This is not bad,” he said. 斯坦利像在家里一样。“这里还不太糟”他说。 P41. But suddenly the wind blew and Stanley was cold. The rain fell and he was wet. 但是，忽然风吹过来，斯坦利觉得很冷。 下雨了，他浑身湿透。 P42. “This is worse than the cave,” said Stantley. He made walls to keep out the wind. “这里比洞穴还糟糕。”斯坦利说。 他砌墙来阻挡风。 P43. He made a roof to keep out the rain. 他做屋顶来阻挡雨。 P44. He made a door, windows and chimney. He made a house! 他制作了门、窗子和烟囱。 他建造了一个房子！ P45. “That's the first house I ever saw,” said a field mouse. “这是我见过的第一个房子。”一只田鼠说。 P46. “It's the first one I ever made,” said Stanley. “Won't you stay here and live with me?” “它是我建的第一个房子。”斯坦利说。“你愿意留下来和我一起住吗？” P47. “I can't. I belong in the field. But I will come and visit you from time to time,” said the field mouse. “我不能。我住在田野里。但是我会不时的拜访您的。”田鼠说。 P48. Stanley painted pictures. 斯坦利绘画。 P49. He planted seeds in the ground and watched them grow. 他在地里播种，看着作物长大。 P50. He loved his house. But he was lonesome. “I wonder how my friends are,” he said. 他喜爱他的房子。但是他很孤单。 “我想知道我的朋友们怎么样了。”他说。 P51. The cavemen were out hunting for animals. They carried their clubs. 洞穴人出去狩猎动物，他们扛着棍棒。 P52. “Look who's after us with their silly clubs,” said the animals. “Let's chase them out of here!” “快看，我们后面那些拿着愚蠢的棍棒的家伙们”动物们说。“让我们把他们赶出这里！” P53. They chased the cavemen. Stanley saw the cavemen running. 他们追赶洞穴人。斯坦利看到洞穴人在跑。 P54. “Don't be afraid,” he said. “I won't let them hurt you.” “不要怕”他说。“我不会让他们伤害你们。” P55. He made the animals go away. 他让动物们离开。 P56. “You saved us, Stanley,” said the cavemen. “Thank you.” “你救了我们，斯坦利。”洞穴人说。“谢谢你。” P57. “Come back and live in our cave,” said one caveman. “回洞穴来住吧。”一个洞穴人说。 P58. “Cave are old-fashioned,” said Stanley. “Come and see where I live.” “洞穴都过时了。”斯坦利说。“来，看看我住的地方。” P59. He showed them his house. 他给他们展示他的房子。 P60. “A cave is for bears. A house is for people,” said Stanley. “洞穴是熊住的。房子才是人住的。”斯坦利说。 P61. “Yor are right, Stanley,” said the cavemen. “This is the way we want to live.” “你说的对，斯坦利。”洞穴人说。“这才是我们要居住的方式。” P62. They all made houses. 他们都开始建房子。 P63. Stanley showed them how to paint pictures and plant seeds. 斯坦利给大家演示怎样绘画和种植。 P64. He showed them how to be nice to each other and kind to animals, and everybody was happy. 他给他们演示怎样对人友好，和对动物友善，每个人都很快乐。

Greg's High School Reunion, Amazon, Hollywood, Independence, Nervousness, 20 Years, Old People, P-38, Filming, Kid Actors, World Of Crazy, Underwire, Mayonnaise, Wine Sushi, Combat, Ronda Rousey, Running Sucks, POPINA, Shame Chips

Caspases work as branch managers When a growing axon nears its target, it arborizes, or branches, to form numerous synaptic connections. Campbell and Okamoto reveal that localized caspase activation downstream of Slit-Robo signaling promotes arbor dynamics and restricts arbor growth. This biosights episode presents the paper by Campbell and Okamoto from the November 25, 2013, issue of The Journal of Cell Biology and includes an interview with lead author Douglas Campbell (formerly at the RIKEN Brain Science Institute, Japan, and currently at the Max Planck Institute for Brain Research, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research. Subscribe to biosights via iTunes or RSS View biosights archive The Rockefeller University Press biosights@rockefeller.edu

Walther HP - An early and rare version of the now famous P38.