Podcasts about Arni

Span, die legendäre Berner Mundartrock-Band, feiert ihr 50-jähriges Bestehen mit dem neuen Album «Auesiauem». Seit ihrer Gründung im Jahr 1972 als Grünspan haben sie die Schweizer Musikszene massgeblich geprägt und sind bis heute aktiv. Und nein, es gibt nicht nur «Louenesee»! Span hiessen ursprünglich Grünspan und wurden 1972 gegründet. 1975 änderte der Bandname zu Span – und auch 50 Jahre später existiert die Band weiterhin unter diesem Namen. Natürlich sind die Zeiten des alten Bauernhauses in der Hämlismatt bei Arni längst vorbei. Und vermutlich dient auch kein Kartoffelkeller mehr als Übungsraum. Fast ebenso klar ist, dass es auch Mitgliederwechsel gab, immerhin sind aus der Urformation noch zwei übriggeblieben: Sänger/Gitarrist Schöre Müller und Sänger/Bassist Christoph Kohli. Und natürlich singen sie auch heute noch auf Mundart, den Titel «älteste Mundartband der Schweiz» haben sie sich dabei redlich verdient. Und nun feiert die Band 2025 ihr 50-jähriges Jubiläum, mit Tour und dem neuen gelungenen Album «Auesiauem», ein Album, das man streamen kann – aber auch «altmodisch» physisch auf CD und Vinyl erwerben kann. 12 Jahre nach ihrem letzten Studioalbum hätte es etwas länger ausfallen dürfen als gerade mal 31 Minuten, doch gut zu wissen: Die Band ist sich und ihrem Stil treu geblieben und scheint kein Ablaufdatum zu kennen. Schöre Müller und Christoph Kohli sind live zu Gast im Swissmade bei Moderatorin Marietta Tomaschett. Für alle Alt-Hippies ist Einschalten ein Muss, für alle Fans sowieso.

This episode of Don't Miss a Beat, recorded at the American College of Cardiology (ACC) 2025 Annual Scientific Sessions, explores the evolving landscape of heart failure with preserved ejection fraction (HFpEF) treatment, focusing on the implementation of combination therapies. Hosts Steve Greene, MD, and Muthiah Vaduganathan, MD, MPH, discuss the transition from a previously limited treatment landscape to a new era with multiple proven therapeutic options. To open the episode, Greene argues in favor of rapid-sequence implementation of HFpEF therapies, drawing parallels to the established 4-pillar guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF). He highlights 3 key classes of medications—SGLT2 inhibitors, non-steroidal mineralocorticoid receptor antagonists (MRAs), and incretin-based therapies—as the foundation of HFpEF treatment. He emphasizes the importance of early and aggressive therapy initiation to maximize clinical benefits and reduce the risk of delayed or missed treatment opportunities among this population. Vaduganathan acknowledges the strength of the data supporting combination therapy but suggests a more risk-based approach, considering the broad clinical variability among HFpEF patients. He advocates for prioritizing rapid implementation in high-risk patients, such as those recently hospitalized, while allowing a more measured approach for lower-risk individuals. The discussion also touches on the role of phenotyping in tailoring treatment decisions, with GLP-1 receptor agonists being particularly relevant for patients with obesity and ARNi potentially benefiting those with mildly reduced ejection fraction. Looking ahead, the hosts preview upcoming trials, including CONFIDENCE and CONFIRMATION, which will evaluate combination therapy strategies in chronic kidney disease and HFpEF populations. They also discuss the potential of fixed-dose combination therapies to simplify implementation and improve adherence. The episode closes with both experts agreeing on the need for a structured, evidence-based approach to HFpEF treatment while emphasizing the importance of translating trial data into real-world practice. Relevant disclosures for Vaduganathan include Amgen, AstraZeneca, Bayer AG, Boehringer Ingelheim Pharmaceuticals, Cytokinetics, Lexicon, and others. Relevant disclosures for Greene include Amgen, AstraZeneca, Bayer Healthcare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, Cytokinetics, and others. Chapters 00:00-Intro 02:30-Argument for Rapid Sequencing 05:32-Argument Against Rapid Sequencing 10:00-Argument for Risk-Based Sequencing 14:25-Pillars of GDMT in HFpEF

In this episode of Creatives Grab Coffee, Arni Thor Jonsson from Republik (Iceland) dives into the intricacies of video production, documentary filmmaking, and running a creative business in Iceland. Arni shares his unique journey from growing up immersed in his father's pioneering production company to founding Republik with his brother, highlighting the lessons learned from working with international crews and navigating unpredictable conditions. Discover valuable insights on balancing commercial work with long-format documentaries, managing creative partnerships, and overcoming production challenges like unpredictable weather and tight budgets. This conversation is packed with practical advice and inspiration for marketers and filmmakers aiming to thrive in competitive, specialized markets.TIMESTAMPS00:00 - Episode Introduction and Guest Welcome02:19 - Guest Bio: Arni Thor Jonsson from Republik04:26 - Growing up in a family-run production business08:09 - Starting Republik and transitioning to independent projects10:07 - Navigating from commercials to documentaries and long-format content12:11 - Insights from buying out a business partner16:01 - Understanding the video production scene in Iceland19:37 - Standing out creatively in a competitive market22:23 - Navigating challenges of filming in unpredictable weather conditions27:13 - Overview of Iceland's corporate video industry31:09 - How freelance filmmakers are shaping Iceland's video market34:16 - Experience working with Kanye West on a music video shoot36:46 - Republik's future ambitions in long-format filmmaking38:41 - Returning to school to enhance documentary filmmaking skills43:58 - The importance of impartial storytelling in documentaries47:15 - Creating and selling original TV series to networks49:01 - Managing and collaborating with Republik's roster of directors57:46 - Origin of the name “Republik”59:00 - Closing Remarks and Final ThoughtsSPONSORS:Canada Film Equipment: www.CanadaFilmEquipment.comAudio Process: www.Audioprocess.ca

Kurz vor 03:00 Uhr habe es in Arni zweimal laut geknallt. Die Anwohner hätten dann beobachtet, wie die Täter mit einem Auto Richtung Oberlunkhofen geflüchtet sind, heisst es bei der Kantonspolizei Aargau auf Anfrage. Weiter in der Sendung: · Übernachtungen in der Notschlafstelle in Baden bleiben beliebt. 2023 haben 1660 Personen in der Notschlafstelle übernachtet, 2024 waren es gegen 1800. · 9 Millionen Franken für den Aargauer Wald. Dies beantragt der Regierungsrat dem Grossen Rat für das Naturschutzprogramm Wald (2026 - 2031). Mit dem Geld sollen unter anderem Waldränder ökologisch aufgewertet werden.

Is low blood pressure hindering your heart failure treatment? How do you balance life-saving medications with hypotension? We explore the definitions, causes, and practical solutions to optimize patient care. Learn how to navigate ARNI, beta-blockers, SGLT2 inhibitors, and MRAs effectively.

Ever since we invented makefiles, the programming world has been wrestling with the problem of building software stacks reliably. This week we're going to look at one of the most ambitious solutions available - Nix. Nix tries to do everything from invoking your compiler to installing your language, and even providing your operating system. But how does it work in theory, and how well does it work in practice?Joining me to discuss is Julian Arni, a Nix-enthusiast and creator of a build/test/deploy service called Garnix.Nix has been one of my go-to tools for years - I hope it'll find its way into your stack.–Nix Overview: https://nixos.org/explore/Nix Tutorial: https://nix.dev/tutorials/first-steps/Nix Flakes: https://nixos.wiki/wiki/FlakesThe Nix Package List: https://search.nixos.org/packagesGarnix.IO: https://garnix.io/Julian's NixCon Talk, Call by Hash: https://www.youtube.com/watch?v=fU9ogB9hZZASupport Developer Voices on Patreon: https://patreon.com/DeveloperVoicesSupport Developer Voices on YouTube: https://www.youtube.com/@developervoices/joinKris on Bluesky: https://bsky.app/profile/krisajenkins.bsky.socialKris on Mastodon: http://mastodon.social/@krisajenkinsKris on LinkedIn: https://www.linkedin.com/in/krisjenkins/

Preprost človek, ki je odraščal v vaškem okolju, je prvič prišel v mesto in poiskal prenočišče v ...Iz knjige Drobne zgodbe za dušo, ki je izšla pri založbi Ognjišče.

Infos zu Bechterew, Influenza, ARNI, Wochenendsport, Lipoprotein(a), Vitamin K2 und Klimakrise

Vi intervjuar idag nordiska koncernen Relais Groups VD Arni Ekholm som berättar om bolagets affärsmodell som förvärvsdrivet bolag, varför de valt att specialisera sig på den nordiska fordonseftermarknaden. Arni ger oss en inblick i hur bolaget arbetar för att driva vinsttillväxt genom både förvärv och organiska initiativ. Med oss i studion har vi även Pia Rosqvist-Heinsalmi, ansvarig aktieanalytiker för Relais. Pia delar med sig av sina tankar kring potential, potentiella utmaningar och Relais positionering.Länk till analyserna: www.carnegie.se/en/commissioned-research/relais/

Udesno bez povratka? Unija CDU/CSU je u Bundestagu uz pomoć AfD-a pokušala progurati zakon za ograničenje migracije - usprkos konsenzusu demokratskih stranaka da ne surađuju s populističkom desnicom. To je izazvalo burne reakcije javnosti ali i rasprave oko toga koliko je još jak "protupožarni zid" prema AfD-u u koji se zaklinje Unija CDU/CSU. Nenad Kreizer o odnosu demokratskih stranaka prema desnim populistima razgovara s profesorom Franom Osrečkim iz Berlina i reporterom Filipom Slavkovićem. Von Nenad Kreizer.

God’s focus on Israel – importance of the land, the people, the nation with Arni Klein For the previous discussion with Arni (Part 1) click here (for previous Heartbeat Israel episodes click here) We are back with Arni Klein live from the Galilee. Grant and Gregg facilitate a follow-on discussion and Q&A for those on the Zoom call. […]

God’s focus on Israel – importance of the land, the people, the nation with Arni Klein For the previous discussion with Arni (Part 1) click here (for previous Heartbeat Israel episodes click here) We are back with Arni Klein live from the Galilee. Grant and Gregg facilitate a follow-on discussion and Q&A for those on the Zoom call. […]

devocional Lucas leitura bíblica Quando Jesus começou a sua atividade tinha cerca de trinta anos. Era filho de José, como se pensava, filho de Eli, filho de Matat, filho de Levi, filho de Malqui, filho de Janai, filho de José, filho de Matatias, filho de Amós, filho de Naum, filho de Esli, filho de Nagai, filho de Maat, filho de Matatias, filho de Simei, filho de Josec, filho de Jodá, filho de Joanan, filho de Ressa, filho de Zorobabel, filho de Salatiel, filho de Neri, filho de Malqui, filho de Adi, filho de Cosam, filho de Elmadam, filho de Er, filho de Jessua, filho de Eliézer, filho de Jorim, filho de Matat, filho de Levi, filho de Simeão, filho de Judá, filho de José, filho de Jonam, filho de Eliaquim, filho de Melea, filho de Mená, filho de Matatá, filho de Nachon, filho de David, filho de Jessé, filho de Jobed, filho de Booz, filho de Salá, filho de Nachon, filho de Aminadab, filho de Admin, filho de Arni, filho de Hesron, filho de Peres, filho de Judá, filho de Jacob, filho de Isaac, filho de Abraão, filho de Tera, filho de Naor, filho de Serug, filho de Reú, filho de Peleg, filho de Éber, filho de Chela, filho de Quenan, filho de Arpaxad, filho de Sem, filho de Noé, filho de Lamec, filho de Matusalém, filho de Henoc, filho de Jared, filho de Malaliel, filho de Quenan, filho de Enós, filho de Set, filho de Adão, filho de Deus. Lucas 3.23-38 devocional Jesus fez tudo no tempo certo. Não foi dado a precipitações, a começos soluçados ou a arrancadas extemporâneas. Até o início do Seu ministério terreno aconteceu numa altura mais do que maturada. Antes de Se propor salvar o mundo cumpriu com as singelas responsabilidades familiares. Cuidou de ser fiel anonimamente para depois Se doar publicamente. A autoridade para ministrar adveio daquilo que também viveu no recato do lar. Jesus pregou o que experienciou da infância à idade adulta. Ao fim de trinta anos estava totalmente por dentro das lutas que qualquer ser humano enfrenta. A Sua encarnação deixa claro que não existem problemas na terra que Ele não tenha enfrentado. Daí ter desafiado os Seus seguidores a abraçar o Seu próprio estilo de vida. Sim, Jesus jamais negou as Suas origens para que nenhuma pessoa esquecesse as suas: Deus. - jónatas figueiredo Oramos para que este tempo com Deus te encoraje e inspire. Da a ti próprio espaço para processar as tuas notas e oração e sai só quando se sentires preparado.

Now when all the people were baptized, and when Jesus also had been baptized and was praying, the heavens were opened, and the Holy Spirit descended on him in bodily form, like a dove; and a voice came from heaven, "You are my beloved Son; with you I am well pleased." Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel, the son of Neri, the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalal

Po ponedeljkovem požaru v domu starejših v Beogradu, v katerem je umrlo osem ljudi, se postavlja vprašanje o požarni varnosti v slovenskih domovih za starejše. Na Združenju za požarno varnost pravijo, da je za požarno varnost bolje poskrbljeno v novejših zavodih, medtem ko je požarna varnost v starejših ustanovah v veliki meri odvisna od proaktivnosti direktorjev. Na Združenju dodajajo, da bi bilo to področje smiselno bolj natančno sistemsko urediti.

The annual Groove Cruise exploration from Miami to the Caribbean has arrived, and Markus Schulz will be heavily involved with a selection of sets throughout the duration. Prior to boarding, he checked in with a new edition of Global DJ Broadcast, and was in a position to world premiere his upcoming instrumental single piece, Enter the Portal. Markus was also joined by Coldharbour contributors ALAT for the guestmix, and included their own world premiere of their upcoming single, Lakes of the Dead.    Hope you enjoy the show. Markus' 30 minute streaming series Global DJ Broadcast Weekly Drive has resumed for 2025, with the newly released episode 35 available now on Spotify, Apple Music and Amazon Music.   Tracklist:   The Essentials with Markus Schulz 01. Armin van Buuren & Omnia - Love 02. Cendryma - Fracture [Deeper Shades] 03. JOA - Missing Part of Me 04. Purple Disco Machine & Friedrich Liechtenstein - Die Maschine 05. Nicky Elisabeth - The Lights (Nicky Elisabeth Remix) [In Bloom] 06. Robert Nickson - Spiral (Forty Cats Remix) [A Moment of Sunrise] 07. Protoculture & Freak E Beatz - Vespera 08. BLR, Matt Sassari & Truetone - Submerge 09. KhoMha - Tanha 10. Orjan Nilsen - Between Sheets 11. Paul Oakenfold - Theme for Great Cities (Revisited) 12. Massano - The Lights 13. DR. DRTY vs. Stefanno b2b Julianno - Feel Alive (Mostly Cloudy Tech Remix) 14. Ben Gold - Space Sex [Global Selection] 15. Spartaque - Falling Through Light [Down the Rabbit hole] 16. Markus Schulz - Enter the Portal [World Premiere] 17. Lemon & Einar K - Anticipation [Hall of Fame]   ALAT 01. ALAT & Cez Are Kane - Zero 02. ALAT - Lakes of the Dead 03. ID 04. ALAT vs. Solid Stone, Jennifer Rene & Arkham Knights - Pushing Up on Knull (Maciej Celewski Mashup) 05. Arni - Space (ALAT Remix) 06. Marcel Woods - Advanced (ALAT & Arni Remix) 07. Three Drives - Greece 2000 (Arni & ALAT Remix)   Back with Markus Schulz 18. Daxson - Intuition 19. Andy Moor & Adina Butar - Wild Dream 20. Markus Schulz x William Schneider - Let Your Mind Be Free 21. Jardin - Shift 22. Dan Thompson - Lost Soul 23. Radion6 - Salvation 24. ALAT - Feel Right 25. Artento Divini - Mangrove  

Heartbeat Israel Arni Klein and Emmaus Way Join us as Grant and Gregg speak with Arni Klein in the land to gain a fresh perspective on what is happening in Israel, especially the spiritual battle over Jerusalem. Arni and Yonit Grant and Arni have been friends for over 35 years and met at One Accord Fellowship in […]

Heartbeat Israel Arni Klein and Emmaus Way Join us as Grant and Gregg speak with Arni Klein in the land to gain a fresh perspective on what is happening in Israel, especially the spiritual battle over Jerusalem. Arni and Yonit Grant and Arni have been friends for over 35 years and met at One Accord Fellowship in […]

Midnighters, Welcome to another electrifying episode of The Midnight Project! This week's session is a journey through pounding basslines, mesmerizing melodies, and a host of tracks to keep your energy soaring. We kick things off with NoNameLeft's "Oscillate," setting the perfect tone for what's to come. Get ready to lose yourself in the grooves of Calpas, Kos:mo, and Pablo Say's collaboration with Anna Tur—featuring my private edit of "My Life," a highlight you don't want to miss. The beats keep coming with PETER PAHN's infectious "Let The Beat Control Your Body" and the deep, cosmic sounds of Pleasurekraft's "At Home in the Universe." PAGANO, Mattia Saviolo, and Arni push us further into the heart of peak-hour techno, before Hanstler and Bart Skils (with a stellar Konstantin Sibold remix) close in on the finale. And to wrap it up—"Gentry," my release played on Awakenings by Joris Voorn, drops to ensure we end on a high. Don't miss a single track. Check out the full playlist right here: https://www.1001tracklists.com/source/80bhhv/the-midnight-project/index.html Thanks for tuning in and being part of the journey. See you next week! Sebastiaan

If you're curious about how to become a follower of Jesus, visit: https://MorningMindsetMedia.com/MeetJesus (this is an EXTERNAL resource, not owned by the Morning Mindset. Please do not leave messages for Carey there. See below for contact info). ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ⇒Check out all of Carey's books - for adults and kids, fiction and non-fiction : https://CareyGreen.com/books ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ TODAY'S SCRIPTURE: GENESIS 49: 10 - The scepter shall not depart from Judah, nor the ruler's staff from between his feet, until tribute comes to him; and to him shall be the obedience of the peoples.  LUKE 3:33 - the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ SUPPORT OUR WORK: (not tax-deductible) -- Become a monthly partner: https://mm-gfk-partners.supercast.com/ -- Support a daily episode: https://MorningMindsetMedia.com/daily-sponsor/ -- Give one-time: https://give.cornerstone.cc/careygreen ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ CONTACT US AT: Admin@MorningMindsetMedia.com 

Kun Relais listautui Helsingin pörssin First Northiin viisi vuotta sitten, se näyttäytyi autojen varaosien tukkukauppana, jolla oli omia valaistustuotteita. Yrityskaupat ovat muuttaneet Relaisin muotoa melkoisesti. Vuonna 2021 Relais osti Suomesta Raskonen ja Ruotsista STS:n eli Sydhamnens Trailer Service AB:n, jotka kumpikin ovat raskaan kaluston huoltoyhtiöitä. Tällä hetkellä korjaamotoiminta tuo suunnilleen kolmanneksen Relaisin liikevaihdosta. Yrityskaupat ovat olennainen osa Relaisin strategiaa. Yhtiö esittäytyykin olevansa "johtava konsolidoija ja yritysostoalusta ajoneuvojen jälkimarkkinoilla Pohjoismaissa ja Baltiassa". Relaisin voi mieltää toimialaerikoistuneeksi sarjayhdistelijäksi. Omistaja-arvoa pyritään kasvattamaan sillä, että yritysostokohteet ostetaan edullisilla kertoimilla, minkä jälkeen ostokohteita pyritään panemaan tehokkaampaan kuntoon toimialaosaamisen avulla. Lisäksi saattaa tulla synergiahyötyjä muiden Relaisiin kuuluvien yhtiöiden kanssa. Toimitusjohtaja Arni Ekholm korostaa yrityskaupoista kertyvää osaamista. "Kompetenssin kumulointi on ihan yhtä tärkeää kuin pääoman kumulointi." Relais tavoittelee 50 miljoonan euron EBITAa eli tulosta ennen poistoja ensi vuoden loppuun mennessä. Kyse on pro forma -luvusta: tavoitteena on, että ensi vuoden lopussa kasassa on sellainen kokonaisuus, joka vuositasolla tekee 50 miljoonan EBITAn. Omavaraisuusaste ei enää kovin paljon jousta, joten omaa pääomaa on luultavasti vahvistettava joko laskemalla liikkeelle uusia osakkeita tai hybridilaina. Piensijoittaja voi pelätä valikoiduille sijoittajille alihintaan suunnattua osakeantia. ”En näkisi sellaista kauhean järkevänä oikeastaan kenenkään kannalta. Uskon, että jos tällainen uuden osakepääoman kerääminen tulisi ajankohtaiseksi, ainoa oikeastaan järkevä motivaatio meille olisi joku partneri, joka toisi jotain siihen kuvioon”, Arni Ekholm sanoo. Yhteistyössä: Relais Relaisin sijoittajasivut: https://relais.fi/sijoittajat/

Pēc vērienīgas rekonstrukcijas Rīgas pilī šoruden atgriezies Latvijas Nacionālais vēstures muzejs (LNVM). Lai arī ar pilnu jaudu darbību tas atsāks tikai nākamajā gadā, jau šobrīd interesentiem ir iespēja apskatīt rekonstruētās telpas un apmeklēt pasākumus. Tieši tāpēc novembra pirmajā "Atsperē" tiekamies ar muzeja direktoru Arni Radiņu.  Inta Zēgnere: Skaists notikums, ko esam piedzīvojuši – Rīgas pils ir atvērta, un Latvijas Nacionālais vēstures muzejs sāk lēnām atgriezties šajās telpās. Šobrīd tās vēl skatāmas bez ekspozīcijām, taču varbūt visupirms, Arni, atgādiniet pašus elementārākos faktus par Rīgas pili... Arnis Radiņš: Tā, kuru mēs šobrīd redzam, ir trešā Rīgas pils. Pirmā tika nopostīta, un tika ierādīta vieta otrajai – šajā pašā vietā, kur atrodas trešā. Taču otru toreiz arī nopostīja, un šī ir 1515. gada versija, kura uzbūvēta uz 1330. gada versijas jeb otrās pils pamatiem. Izklausās diezgan sarežģīti, bet patiesībā viss ir ļoti vienkārši. Šīs mājas pamatos var redzēt kaut ko no 14. gadsimta pils, bet pamatkorpuss ir no 16. gadsimta. Vakar beidzot pati apmeklēju Rīgas pili un biju absolūtā sajūsmā – negribējās iet projām: iesaku visiem paskatīties uz šīm telpām un sajust patiešām neparastu atmosfēru… Lai arī veikti restaurācijas darbi, senumu var just. Vai varu lūgt jūs mūs iztēlē izvadāt pa pils telpām? Pa vārtiem ieejam dienvidu korpusā. Šie vārti ir jauni, tie nav no senajiem laikiem: šie vārti izveidoti vēlāk, lai būtu komunikācija [arī ar šo pilsētas daļu]. Īstie vārti, kas ved pilī, atrodas pretējā pusē – ziemeļu korpusā. Šobrīd tie nav pieejami. Pagriežamies pa labi un ieejam vienā no pils pirmā stāva telpām – vestibilā, un redzam ārkārtīgi skaistas velves. Labā ziņa ir tā, ka izdevās pazemināt šīs telpas līmeni: agrāk cilvēki bija pietiekami slinki: ja nu kas, tika uzlikta arvien jauna un jauna grīda. Tagad kādi četrdesmit centimetri atgūti no sākotnējā līmeņa, kaut gan pie vienas kolonnas var redzēt, ka vēl kādu četrdesmit centimetru pietrūkst...  Stāvu augstāk ir lielākās pārvērtības: atjaunota kapela un remteris jeb baznīca un ēdamtelpa – tādā izskatā, kādas tās kādreiz bija, jo [laika gaitā] tām tika iebūvēts viens starpstāvs. Restaurācijas gaitā tas tika izņemts ārā, un šobrīd telpa ir visu septiņu metru augstumā – tāda, kāda tā reiz bijusi.  Ceturtais stāvs arī ir pārveidots, nostiprināts. Tas tapis vēlāk tapis, bijušā ieroču stāva vietā, un nekādus senus brīnumus tur redzēt nevar, izņemot atsegtās dienvidu korpusa sienas: tagad var redzēt, kādas tās izskatījās kādreiz – ķieģeļu mūrējums. No visām telpām mans favorīts ir pagrabs… Tā ir vismazāk pārveidotā telpa. Pareizāk sakot – izņemot ārā visas starpsienas, telpas ir vistuvāk sākotnējai substancei – pieņemu, ka kopš 1515. gada tās neviens šādā izskatā nav redzējis, jo tūlīt, kā jau pagrabā, tika ierīkotas noliktavas, telpa tika sadalīta mazākās daļiņās. Tagad tam visam var iziet cauri, un šis skats simt metru garumā ir diezgan iespaidīgs... Arī šeit labā ziņa ir tā, ka pagrabs atjaunots tuvu tam augstumam, kāds tas bija. Jo arī šeit bija sakrājušies uzbērumi, bet tagad velves un kolonnas nolasās labāk nekā iepriekš: telpa ieguvusi majestātisku skatu! Pie tam interesanti, ka viens gals šai telpai ir ar labākām velvēm, proti, izpildīts kvalitatīvāk, bet otrs ir vienkāršāks, izskatās, ka būvēts ātrākā tempā. Ir divas teorijas: viena no tām – ka bijuši divi amatnieki, divi meistari, kas mūrējuši: viens bijis kārtīgāks, viens nekārtīgāks. Jo patiešām meistari bija divi. Tur, kur ir greznākās velves, bijusi paredzēta prestižāka vieta, nevis vienkārši pagrabs. Iespējams, bruņinieku kapenes vai kas cits.  Pagrabs sagādāja lielāko arheoloģisko pārsteigumu: pils izrakumu laikā atradām hipokausta krāsni, par kuru jau tagad plaši izskanējis. Tas interesantākais fakts ir tas, ka šī krāsns nav saistāma ar pili – tā ir vecāka. Vēl vecāka par 1330. gadu! Bet kā tas nākas? Jo parasti taču tādas krāsnis ierīkoja, ja bija kādi konventi, klosteri. Šķiet, arī Piritas klosterī ir šāda veida krāsns.  Šis ir ļoti tipisks apkures veids tā laika celtnēs.  Bet ko tad apkurināja, ja nebija pils? Pēc rakstītiem avotiem zinām, ka šai pilij pilsēta ierādīja vietu pie Svētā Gara hospitāļa – pie pilsētas mūra, kurā atradās Svētā Gara tornis ar vārtiem pie zirgu staļļiem, daļēji pilsētas teritorijā. Šajos izrakumos pagalma dziļumā atradām gan koka pilsētu ar koka ielām jeb koka bruģējumu un koka mājām, atradām arī pilsētas mūri un Svētā Gara torni. Zirga staļļus gan neatradām, lai gan... smaka bija saglabājusies! Patiešām?!  Jā, vienā izrakumu laukumā... Apmēram ir nojauta, kur tie varētu būt bijuši, bet konstrukciju ziņā šīs liecības neatradām. Bet krāsns ir no Svētā Gara hospitāļa, kura sienas atradām izrakumos. Tā ir ēka, kas iepriekš atradās pils vietā. Tad tā tikusi nojaukta un uzbūvēta pils. Tas bija hospitālis, vai tomēr konvents? Tur ir valodnieciska nianse. Ja tulko no latīņu valodas, tad tas ir hospitālis, ja tulko no vācu valodas – konvents. Tā bija patversme, kur pavadīt vecumdienas – arī bagātiem cilvēkiem. Šis bija ļoti bagāts konvents – tam bija gan pārtika, gan nauda, gan viss pārējais. Tas aprakstīts hronikās. Nonākot velvju pagrabu teritorijā, uzreiz rodas asociācijas: tā taču ir Ārzemju mākslas muzeja izstāžu zāle, tikai ar ieeju no citas puses. Jā un nē. Jo Ārzemju mākslas muzeja Velvju zāle aizņēma daļu no šīs telpas. Ieeja ir tieši turpat. Bet velves izskatījās savādāk tāpēc, ka tur bija ierīkota grīda, bet otra daļa, kas tagad redzama, greznākā daļa – tā bija Vēstures muzeja īpašums. Es to vēl atceros kā ogļu pagrabu, vēlāk tur atradās keramikas glabātuve. Bet kopumā, veselumā, visā šajā garumā šo telpu sen neviens nav redzējis – tagad ir unikāla iespēja to apskatīt. Pagrabs ir krāšņākā telpa… Negribu neko sliktu teikt par remteri un kapelu, arī tās ir vienreizējas un tādas Latvijas pilīs vairs nav saglabājušās. Taču tās ir stipri pārveidotas. Garu var just, bet faktiski tās ir ne tik oriģinālas, jo tur ir jauni, pārveidoti logi. Arī pagrabs izskatās tīri svaigs! Kā jau pēc restaurācijas – viss ir "uzfrišināts". Bet laiks darīs savu. Nosūbēs un viss atkal nostāsies savās vietās. Grīdās parādīsies pirmie papēžu nospiedumi, uz sienām – plecu nospiedumi un skrāpējumi. Tas ir neizbēgami. Māja nolietojas. Sterili izskatās tikai pašā sākumā. Cilvēks atstāj savas pēdas. Latvijas Nacionālā vēstures muzeja rīcībā ir visa kapelas daļa – četri korpusi. Pieejams šobrīd ir dienvidu korpuss: no 12 000 kvadrātmetriem šobrīd 4400 ir gatavi, un pils gaida vēl trešo kārtu, lai to pabeigtu. Tuvāko četru gadu laikā katru gadu nodosim pa vienai ekspozīcijai. Sāksim ar ekspozīciju "Straumējot laiku" ceturtajā stāvā – tā būs tāda ļoti saspiesta Latvijas vēsture no Akmens laikmeta līdz šodienai. Cilvēks varēs paātrinātā tempā iziet cauri visai mūsu vēsturei. Nākošā ekspozīcija būs pagrabā, tās nosaukums būs "Livonijas pilis", kas rādīs to lielisko materiālu, kas ir muzeja rīcībā no Latvijas arheoloģiskajos izrakumos iegūtajām liecībām. Tā varētu būt vēl pēc gada. Pēc tam būs ekspozīcija "Rīgas pils vēsture", bet vēl pēc tam – "Sakrālā māksla", kas atradīsies kapelā jeb baznīcas vietā. Remteris jeb ēdamtelpa netiks ekspozīcijām izmantota, bet paliks tāda, kāda tā ir šobrīd – lai var apjaust šīs telpas apjomu. Telpu varēs izmantot arī dažādiem pasākumiem. Vairāk – ierakstā.

Mit einem dringlichen Auftrag soll die Solothurner Regierung verpflichtet werden, alles zu unternehmen, um das Stahlwerk Gerlafingen zu retten. Eingereicht hat den Vorstoss die SP-Fraktion. Auch im Bundesparlament bleibt das Stahlwerk Thema, mehrere Kommissionen befassen sich damit. Die weiteren Themen dieser Sendung: * Halloween in den Kantonen Aargau und Solothurn: verhältnismässig wenig Vorfälle wurden der Polizei gemeldet. * Arni und Islisberg im Bezirk Bremgarten wehren sich gegen mögliche Windkraftanlagen im benachbarten Kanton Zürich. * Marc Thommen, Präsident des EHC Olten, nimmt Stellung nach der deutlichen 0:7-Niederlage gegen Visp.

नमस्कार, जासूसी कथा और कमांडो मिशन के किस्सों में किसे दिलचस्पी नहीं होती। हालिया, आईसी-814 के हाईजैक पर सीरीज़ के चलते ये किस्सा फिर से चर्चा में है, तो हमने सोचा कि क्यों न किसी ऐसे मेहमान से बात की जाए जो खुद इस घटना में शामिल थें। आज की पुलियाबाज़ी पर हमारे मेहमान हैं आनंद आरणिजी जो IC-814 की घटना में उन पांच अफसरो में से थे जिन्हें भारत सरकार के द्वारा अपहर्ताओं के साथ बातचीत करने के लिए कंदहार भेजा गया था। आज की पुलियाबाज़ी पर वे अपने इस अनुभव को साझा करते हैं। आनंद आरणिजी के साथ पुलियाबाज़ी पर ये दूसरी बातचीत है। इस पहले वे एक R&AW अफसर होने के अनुभव और पाकिस्तान और अफगानिस्तान से संबंधित बातों पर विस्तार से चर्चा कर चुके हैं। इन एपिसोड के लिंक्स आपको शो नोट्स में मिलेंगे।पुलियाबाज़ी अब यूट्यूब पर वीडियो के साथ भी प्रस्तुत है। अगर आप हमारी बातें वीडियो के साथ देखना चाहते हैं तो हमारे यूट्यूब चैनल Puliyabaazi Hindi Podcast को ज़रूर सब्सक्राइब करें। पुलियाबाज़ी की वेबसाइट puliyabaazi.in पर आप हमारे अन्य एपिसोड्स को आसानी से ढूंढ सकते हैं। तो आइए सुनते हैं आज की पुलियाबाज़ी। Mr Anand Arni is a Distinguished Fellow and Advisor at the Takshashila Institution, and retired as the Special Secretary in the Cabinet Secretariat. He served for over 37 years in the Research and Analysis Wing (R&AW), India's external intelligence agency. He was a part of the hostage rescue team during the Flight IC814 hijacking crisis. Post-retirement, he continues to focus on India's western neighbours.This is the second conversation on Puliyabaazi with Mr. Arni. In an earlier episode, he has shared about his experience of being an R&AW officer, and his insights on Pakistan and Afghanistan. You will find the episode links in the show notes.Puliyabaazi is now available on YouTube with video. If you want to watch our conversations with video, then do subscribe to our YouTube channel Puliyabaazi Hindi Podcast. Related Puliyabaazi:भारत और अफ़ग़ानिस्तान : काबुलीवाला से तालिबान तक. Understanding Afghanistan ft. Anand Arniख़ुफ़िया बातें. Espionage, India Style. ft. Former R&AW Chief Vikram Sood.If you have any questions for the guest or feedback for us, please comment here or write to us at puliyabaazi@gmail.com. If you like our work, please subscribe and share this Puliyabaazi with your friends, family and colleagues.Website: https://puliyabaazi.inGuest: @anand_arniHosts: @saurabhchandra @pranaykotas @thescribblebeeTwitter: @puliyabaazi Instagram: https://www.instagram.com/puliyabaazi/Subscribe & listen to the podcast on iTunes, Google Podcasts, Castbox, AudioBoom, YouTube, Spotify or any other podcast app. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.puliyabaazi.in

Enjoy this podcast? Your support on Patreon helps us in so many ways... Patreon: patreon.com/commonprayerdaily_________________________________________________________________OpeningBlessed be God: Father, Son, and Holy Spirit.And blessed be his kingdom, now and for ever. Amen.Come, let us worship God our King.Come, let us worship Christ, our King and our God.Come, let us worship Christ among us, our King and our God.Holy God,holy and mighty,holy immortal one,have mercy upon us. (3x)Glory be to the + Father and to the Son and to the Holy Spirit,now and always and forever and ever. Amen. From Psalm 51Open my lips, O Lord, *and my mouth shall proclaim your praise.Create in me a clean heart, O God, *and renew a right spirit within me.Cast me not away from your presence *and take not your holy Spirit from me.Give me the joy of your saving help again *and sustain me with your bountiful Spirit.Glory be to the + Father and to the Son and to the Holy Spirit,now and always and forever and ever. Amen. A PsalmPsalm 96Cantate DominoSing to the Lord a new song; sing to the Lord, all the whole earth.Sing to the Lord and bless his Name; proclaim the good news of his salvation from day to day.Declare his glory among the nations and his wonders among all peoples.For great is the Lord and greatly to be praised; he is more to be feared than all gods.As for all the gods of the nations, they are but idols; but it is the Lord who made the heavens.Oh, the majesty and magnificence of his presence! Oh, the power and the splendor of his sanctuary!Ascribe to the Lord, you families of the peoples; ascribe to the Lord honor and power.Ascribe to the Lord the honor due his Name; bring offerings and come into his courts.Worship the Lord in the beauty of holiness; let the whole earth tremble before him.Tell it out among the nations: “The Lord is King! he has made the world so firm that it cannot be moved; he will judge the peoples with equity.”Let the heavens rejoice, and let the earth be glad; let the sea thunder and all that is in it; let the field be joyful and all that is therein.Then shall all the trees of the wood shout for joy before the Lord when he comes, when he comes to judge the earth.He will judge the world with righteousness and the peoples with his truth. Glory be to the + Father and to the Son and to the Holy Spirit,now and always and forever and ever. Amen. The ReadingsEphesians 5:20–26giving thanks always and for everything to God the Father in the name of our Lord Jesus Christ, submitting to one another out of reverence for Christ.Wives, submit to your own husbands, as to the Lord. For the husband is the head of the wife even as Christ is the head of the church, his body, and is himself its Savior. Now as the church submits to Christ, so also wives should submit in everything to their husbands.Husbands, love your wives, as Christ loved the church and gave himself up for her, that he might sanctify her, having cleansed her by the washing of water with the word, The Word of the LordThanks Be to God Luke 3:23–4:1Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel, the son of Neri, the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, the son of Enos, the son of Seth, the son of Adam, the son of God.And Jesus, full of the Holy Spirit, returned from the Jordan and was led by the Spirit in the wilderness The Word of the LordThanks Be to GodThe Apostles' CreedI believe in God, the Father almighty, creator of heaven and earth;I believe in Jesus Christ, his only Son, our Lord. He was conceived by the power of the Holy Spirit and born of the Virgin Mary. He suffered under Pontius Pilate, was crucified, died, and was buried. He descended to the dead. On the third day he rose again. He ascended into heaven, and is seated at the right hand of the Father. He will come again to judge the living and the dead.I believe in the Holy Spirit, the holy catholic Church, the communion of saints, the forgiveness of sins the resurrection of the body, and the life everlasting. Amen. ExamenIn God's presence, think through the day ahead:the work you will do, the people you will encounter, the dangers or uncertainties you face, the possibilities for joy and acts of kindness, any particular resolutions you need to renew, consider what might draw you from the love of God and neighbor, the opportunities you will have to know and serve God and to grow in virtue, remember those closest to you and all for whom you have agreed to pray, ask God's blessings, guidance, and strength in all that lies before you. Gather up these thoughts and reflections in the wordsOur Savior taught us to say: The Lord's PrayerOur Father, who art in heaven, hallowed be thy Name, thy kingdom come, thy will be done, on earth as it is in heaven. Give us this day our daily bread. And forgive us our trespasses, as we forgive those who trespass against us. And lead us not into temptation, but deliver us from evil. For thine is the kingdom, and the power, and the glory, for ever and ever. Amen. The Collects of the DayO God, because without you we are not able to please you, mercifully grant that your Holy Spirit may in all things direct and rule our hearts; through Jesus Christ our Lord, who lives and reigns with you and the Holy Spirit, one God, now and for ever. Amen. Lord God, almighty and everlasting Father, you have brought us in safety to this new day: Preserve us with your mighty power, that we may not fall into sin, nor be overcome by adversity; and in all we do, direct us to the fulfilling of your purpose; through Jesus Christ our Lord. Amen. Closing PrayersA Prayer of St. ChrysostomAlmighty God, you have given us grace at this time with one accord to make our common supplication to you; and you have promised through your well-beloved Son that when two or three are gathered together in his Name you will be in the midst of them: Fulfill now, O Lord, our desires and petitions as may be best for us; granting us in this world knowledge of your truth, and in the age to come life everlasting. Amen. Glory be to the + Father and to the Son and to the Holy Spirit,now and always and forever and ever. Amen.Lord, have mercy! (3x)God, be gracious to us and bless us and shine Your countenance upon us and have mercy on us.This is the day that the Lord has made; let us rejoice and be glad in it!The Father+ is my hope; the Son, my refuge; the Holy Spirit, my protection: All-Holy Trinity, glory to You!Amen!

Co robić, kiedy obrażają naszą wiarę, kiedy publicznie kpią ze spraw dla nas świętych, depczą sacrum? Zapraszamy na rozmowę z red. Dominiką Szczawińską - teologiem, teatrologiem i dziennikarką pracującą w redakcji katolickiej TVP oraz w Radiu Plus. Napisz do nas! Wesprzyj nas! Wszystkie odcinki z podziałem na cykle tematyczne znajdziesz na www.koinoniagb.pl/podcast Obserwuj kanał Podcast Koinonii Jan Chrzciciel w WhatsAppieRead transcript

Benvenuti ai 4 Vangeli-letture in 1 anno 5 gg a settimanaOggi: Battesimo di Gesu' e genealogia21 Un giorno, dopo che tutte le persone erano state battezzate, anche Gesù si fece battezzare. Dopo il battesimo, mentre era in preghiera, i cieli si aprirono, 22 e lo Spirito Santo sotto forma di colomba si fermò su di lui. Una voce dal cielo disse: «Tu sei il mio amatissimo Figlio, in te mi sono compiaciuto.»23 Gesù aveva circa trentʼanni, quando cominciò il suo pubblico ministero. Era conosciuto come figlio di Giuseppe. Il padre di Giuseppe era Eli, 24 il padre di Eli era Matthat, il padre di Matthat era Levi, il padre di Levi era Melchi, il padre di Melchi era Iannai, il padre di Iannai era Giuseppe, 25 il padre di Giuseppe era Mattatia, il padre di Mattatia era Amos, il padre di Amos era Naum, il padre di Naum era Esli, il padre di Esli era Naggai, 26 il padre di Naggai era Maat, il padre di Maat era Mattatia, il padre di Mattatia era Semein, il padre di Semein era Iosech, il padre di Iosech era Ioda, 27 il padre di Ioda era Ioanan, il padre di Ioanan era Rhesa, il padre di Rhesa era Zorobabele, il padre di Zorobabele era Salatiel, il padre di Salatiel era Neri, 28 il padre di Neri era Melchi, il padre di Melchi era Addi, il padre di Addi era Cosam, il padre di Cosam era Elmadam, il padre di Elmadam era Er, 29 il padre di Er era Giosuè, il padre di Giosuè era Eliezer, il padre di Eliezer era Iorim, il padre di Iorim era Mattat, il padre di Mattat era Levi, 30 il padre di Levi era Simeone, il padre di Simeone era Giuda, il padre di Giuda era Giuseppe, il padre di Giuseppe era Ionam, il padre di Ionam era Eliacim, 31 il padre di Eliacim era Melea, il padre di Melea era Menna, il padre di Menna era Mattatha, il padre di Matthata era Nathan, il padre di Nathan era Davide, 32 il padre di Davide era Iesse, il padre di Iesse era Iobed, il padre di Iobed era Boaz, il padre di Boaz era Sala, il padre di Sala era Naàsson, 33 il padre di Naàsson era Aminadab, il padre di Aminadab era Admin, il padre di Admin era Arni, il padre di Arni era Esrom, il padre di Esrom era Fares, il padre di Fares era Giuda, 34 il padre di Giuda era Giacobbe, il padre di Giacobbe era Isacco, il padre di Isacco era Abramo, il padre di Abramo era Tare, il padre di Tare era Nacor, 35 il padre di Nacor era Seruk, il padre di Seruk era Ragau, il padre di Ragau era Falek, il padre di Falek era Eber, il padre di Eber era Sala, 36 il padre di Sala era Cainam, il padre di Cainam era Arfàcsad, il padre di Arfàcsad era Sem, il padre di Sem era Noè, il padre di Noè era Lamech, 37 il padre di Lamech era Matusalemme, il padre di Matusalemme era Enoch, il padre di Enoch era Iaret, il padre di Iaret era Malleèl, il padre di Malleèl era Cainam, 38 il padre di Cainam era Enos, il padre di Enos era Set, il padre di Set era Adamo, il Padre di Adamo era Dio.Support the Show.Support the Show.

Epic new music by U-G, Bryn Whiting, Alexander Popov, Somnia, Arni, AYDA and more.

Neil Bemenderfer, a key role player on Purdue's Big Ten title team in 1979, celebrates his 68th birthday with us. The 6-foot-10-inch forward/center from Rochester, Ind., was a backup to All-American center Joe Barry Carroll and played for coaches Fred Schaus and Lee Rose after transferring to Purdue from Vanderbilt.  Bemenderfer went on to have a long career in the legal community, most recently as a civil mediator with a company he founded, The Mediation Group, in Indianapolis. From its website:  Bemenderfer began full-time dispute resolution in 2000. Neil has mediated thousands of cases and has been consistently named one of the top mediators in Indiana. He mediates all civil cases, including serious injury and death, complex commercial disputes and workouts, product liability, employment, construction, real estate, and land use. Besides mediating, Neil also chairs medical panel review proceedings under Indiana's medical malpractice laws and is a regular speaker at seminars and training sessions. He is a Fellow of the American College of Civil Mediators, is consistently recognized as an Indiana Super Lawyer (Top 50), and is listed in Best Lawyers in America and The International Who's Who of Commercial Mediation. Born and raised in Rochester, Indiana, Neil attended Purdue University, where he majored in English and played basketball. He was twice awarded the Red Mackey Award for Academic and Athletic Excellence. In 1999, he was named to the Indiana High School Basketball Hall of Fame Silver Anniversary Team and is a Sagamore of the Wabash. He is also an instrument-rated pilot.

Every Purdue fan knows it has been 44 years since the Boilermakers made the Final Four. In today's Arni's Birthday Zoom, we talk with former Purdue basketball manager Ed Potts, who celebrates his 64th birthday today (April 2, 2024). Potts was a student manager for the 1980 team and shares some insightful stories with host Alan Karpick (fellow manager). But there's much more, as Potts provided background on his famous great uncle Ray Kroc and how Potts and his family navigated the McDonald's system in West Lafayette and Lafayette. It's a story of family perseverance, occasional strife, and a trip down memory lane for those who lived on or near campus in the 1970s and 80s.

We celebrate the 43rd birthday (March 25, 2024) of former Purdue All-Big Ten linebacker Niko Koutouvides. We caught up with the Boilermaker who was a key cog (2000-03) in one of the best Boilermaker defenses ever. Koutouvides, who now lives in his home state of Connecticut, helped the Boilermakers to four straight bowl appearances during his standout Purdue career and was one of a couple of handfuls of Boilermaker defenders that spent significant time in the NFL.

Javed Butler, MD, MPH, MBA - Practical Perspectives and Straightforward Strategies for Optimising GDMT in HFrEF: The Role of ARNI as a Fundamental Building Block

We talk to Cardiologist Dr. Jonathan Davis, Director of the Heart Failure program from San Francisco General about goal directed medical therapy in heart failure with reduced ejection fraction (HFrEF). This is part 1 of 2 parts which will cover an overview of GDMT medications, and dive into Beta-blockers and ARNIs. Part 2 to come out next week! | 00.34 - Introduction | | 01.55 - Consult Q: GDMT for HF | Heart failure outcomes | 05.20 - GDMT medication summary and overview | | 07.17 - Effect on blood pressure and relative risk reduction for each drug | | 10.59 - What order to start in | Hint: ALL AT ONCE… if you can | 11.53 - Beta-blockers | When not to start (new HF in VOL), and when to re/start (almost all other times) Tartrate vs Succinate: duration of action | 15.40 - ARNI (Sacubitril-Valsartan) | Potent natriuresis effect Balancing the orthostatics | 20.37 - Outro | [The appearance of external hyperlinks does not constitute endorsements by UCSF of the linked websites, or the information, products, or services contained therein. UCSF does not exercise any editorial control over the information found therein, nor does UCSF make any representation of their accuracy or completeness. All information contained in this episode are the opinions of the respective speakers and not necessarily the views their respective institutions or UCSF, and is only provided for information purposes, not to diagnose or treat.] Music by Amit Apte. Medical Heart Vectors by Vecteezy

The longtime voice of Purdue football and women's basketball Tim Newton celebrates birthday No. 63 (Dec. 5, 2023) with GoldandBlack.com. Newton will be broadcasting his 1000th Boilermaker women's game this season. He was named the 2021 Indiana Sportscaster of the Year by the National Sports Media Association (NSMA). As the top sportscaster in the state, Newton became the first Purdue broadcaster to earn the award since Joe McConnell in 2000. A Boilermaker for most of his life, the Irving, New York, native has worked at Purdue for 33-plus years and graduated from the university in 1981 as a mass communication major.   The fall of 2023 was Newton's 29th football season with the Boilermaker Sports Network. He spent the first 15 years with the network as a producer and host before transitioning into the play-by-play chair as the "Voice of Purdue Football" for the past 14 seasons.  

“The last nine months, no matter what we want to talk about, our customers want to talk about one thing, which is Gen AI.”One year ago, ChatGPT woke the entire world up to the possibilities of Generative AI. Since then, the conversation around AI has not ceased, with constant questions being raised about its safety, accuracy, and potential implications for the tech world. In this episode, Dan hosts a panel at NYC Tech Week 2023, discussing the evolution and potential of Generative AI with Jacopo Tagliabue of Bauplan, Catherine Miller of Flatiron Health, Raghvender Arni of AWS Industries, and Justin Zhao of Predibase. Together, they discuss their companies' adoption of AI, delving into the need for a stable foundation in order to move Generative AI from prototype to production and the works of science fiction today that could be commonplace in the near future.

One of our listeners, Arni, posed an interesting question: "To prevent cats from coming into my house, is it better to keep the balcony doors closed and let sunlight come in through the windows, or should I have the shutters closed to keep out the sun but allow fresh air to enter?" Her dilemma highlights the conflict between the desire to keep cats out and the benefits of natural light and fresh air. Let's go deeper into this issue and explore how we can achieve the best of both worlds.   Key Takeaways: Balancing yin and yang energies in the home is important for creating a harmonious space. Sunlight brings yang energy and is beneficial for energizing and uplifting the space. Fresh air can be brought in through a window while keeping the balcony doors closed to prevent cats from entering   Resources: Feng Shui Checklist - https://www.powerhousefengshui.com/feng-shui-checklist-1 Free Feng Shui Mini Course or Feng Shui 101 - https://www.powerhousefengshui.com/101-fengshui-v2-1   Connect with Patricia Lohan: Instagram - https://www.instagram.com/powerhouse.fengshui/ YouTube - https://www.youtube.com/@PatriciaLohan Website - https://patricialohan.com/ Send us an email: miracles@patricialohan.com

With family: 1 Chronicles 13–14; James 1 1 Chronicles 13–14 (Listen) The Ark Brought from Kiriath-Jearim 13 David consulted with the commanders of thousands and of hundreds, with every leader. 2 And David said to all the assembly of Israel, “If it seems good to you and from the LORD our God, let us send abroad to our brothers who remain in all the lands of Israel, as well as to the priests and Levites in the cities that have pasturelands, that they may be gathered to us. 3 Then let us bring again the ark of our God to us, for we did not seek it1 in the days of Saul.” 4 All the assembly agreed to do so, for the thing was right in the eyes of all the people. Uzzah and the Ark 5 So David assembled all Israel from the Nile2 of Egypt to Lebo-hamath, to bring the ark of God from Kiriath-jearim. 6 And David and all Israel went up to Baalah, that is, to Kiriath-jearim that belongs to Judah, to bring up from there the ark of God, which is called by the name of the LORD who sits enthroned above the cherubim. 7 And they carried the ark of God on a new cart, from the house of Abinadab, and Uzzah and Ahio3 were driving the cart. 8 And David and all Israel were celebrating before God with all their might, with song and lyres and harps and tambourines and cymbals and trumpets. 9 And when they came to the threshing floor of Chidon, Uzzah put out his hand to take hold of the ark, for the oxen stumbled. 10 And the anger of the LORD was kindled against Uzzah, and he struck him down because he put out his hand to the ark, and he died there before God. 11 And David was angry because the LORD had broken out against Uzzah. And that place is called Perez-uzza4 to this day. 12 And David was afraid of God that day, and he said, “How can I bring the ark of God home to me?” 13 So David did not take the ark home into the city of David, but took it aside to the house of Obed-edom the Gittite. 14 And the ark of God remained with the household of Obed-edom in his house three months. And the LORD blessed the household of Obed-edom and all that he had. David's Wives and Children 14 And Hiram king of Tyre sent messengers to David, and cedar trees, also masons and carpenters to build a house for him. 2 And David knew that the LORD had established him as king over Israel, and that his kingdom was highly exalted for the sake of his people Israel. 3 And David took more wives in Jerusalem, and David fathered more sons and daughters. 4 These are the names of the children born to him in Jerusalem: Shammua, Shobab, Nathan, Solomon, 5 Ibhar, Elishua, Elpelet, 6 Nogah, Nepheg, Japhia, 7 Elishama, Beeliada and Eliphelet. Philistines Defeated 8 When the Philistines heard that David had been anointed king over all Israel, all the Philistines went up to search for David. But David heard of it and went out against them. 9 Now the Philistines had come and made a raid in the Valley of Rephaim. 10 And David inquired of God, “Shall I go up against the Philistines? Will you give them into my hand?” And the LORD said to him, “Go up, and I will give them into your hand.” 11 And he went up to Baal-perazim, and David struck them down there. And David said, “God has broken through5 my enemies by my hand, like a bursting flood.” Therefore the name of that place is called Baal-perazim. 12 And they left their gods there, and David gave command, and they were burned. 13 And the Philistines yet again made a raid in the valley. 14 And when David again inquired of God, God said to him, “You shall not go up after them; go around and come against them opposite the balsam trees. 15 And when you hear the sound of marching in the tops of the balsam trees, then go out to battle, for God has gone out before you to strike down the army of the Philistines.” 16 And David did as God commanded him, and they struck down the Philistine army from Gibeon to Gezer. 17 And the fame of David went out into all lands, and the LORD brought the fear of him upon all nations. Footnotes [1] 13:3 Or him [2] 13:5 Hebrew Shihor [3] 13:7 Or and his brother [4] 13:11 Perez-uzza means the breaking out against Uzzah [5] 14:11 Baal-perazim means Lord of breaking through (ESV) James 1 (Listen) Greeting 1 James, a servant1 of God and of the Lord Jesus Christ, To the twelve tribes in the Dispersion: Greetings. Testing of Your Faith 2 Count it all joy, my brothers,2 when you meet trials of various kinds, 3 for you know that the testing of your faith produces steadfastness. 4 And let steadfastness have its full effect, that you may be perfect and complete, lacking in nothing. 5 If any of you lacks wisdom, let him ask God, who gives generously to all without reproach, and it will be given him. 6 But let him ask in faith, with no doubting, for the one who doubts is like a wave of the sea that is driven and tossed by the wind. 7 For that person must not suppose that he will receive anything from the Lord; 8 he is a double-minded man, unstable in all his ways. 9 Let the lowly brother boast in his exaltation, 10 and the rich in his humiliation, because like a flower of the grass3 he will pass away. 11 For the sun rises with its scorching heat and withers the grass; its flower falls, and its beauty perishes. So also will the rich man fade away in the midst of his pursuits. 12 Blessed is the man who remains steadfast under trial, for when he has stood the test he will receive the crown of life, which God has promised to those who love him. 13 Let no one say when he is tempted, “I am being tempted by God,” for God cannot be tempted with evil, and he himself tempts no one. 14 But each person is tempted when he is lured and enticed by his own desire. 15 Then desire when it has conceived gives birth to sin, and sin when it is fully grown brings forth death. 16 Do not be deceived, my beloved brothers. 17 Every good gift and every perfect gift is from above, coming down from the Father of lights, with whom there is no variation or shadow due to change.4 18 Of his own will he brought us forth by the word of truth, that we should be a kind of firstfruits of his creatures. Hearing and Doing the Word 19 Know this, my beloved brothers: let every person be quick to hear, slow to speak, slow to anger; 20 for the anger of man does not produce the righteousness of God. 21 Therefore put away all filthiness and rampant wickedness and receive with meekness the implanted word, which is able to save your souls. 22 But be doers of the word, and not hearers only, deceiving yourselves. 23 For if anyone is a hearer of the word and not a doer, he is like a man who looks intently at his natural face in a mirror. 24 For he looks at himself and goes away and at once forgets what he was like. 25 But the one who looks into the perfect law, the law of liberty, and perseveres, being no hearer who forgets but a doer who acts, he will be blessed in his doing. 26 If anyone thinks he is religious and does not bridle his tongue but deceives his heart, this person's religion is worthless. 27 Religion that is pure and undefiled before God the Father is this: to visit orphans and widows in their affliction, and to keep oneself unstained from the world. Footnotes [1] 1:1 For the contextual rendering of the Greek word doulos, see Preface [2] 1:2 Or brothers and sisters. In New Testament usage, depending on the context, the plural Greek word adelphoi (translated “brothers”) may refer either to brothers or to brothers and sisters; also verses 16, 19 [3] 1:10 Or a wild flower [4] 1:17 Some manuscripts variation due to a shadow of turning (ESV) In private: Amos 8; Luke 3 Amos 8 (Listen) The Coming Day of Bitter Mourning 8 This is what the Lord GOD showed me: behold, a basket of summer fruit. 2 And he said, “Amos, what do you see?” And I said, “A basket of summer fruit.” Then the LORD said to me,   “The end1 has come upon my people Israel;    I will never again pass by them.3   The songs of the temple2 shall become wailings3 in that day,”      declares the Lord GOD.  “So many dead bodies!”  “They are thrown everywhere!”  “Silence!” 4   Hear this, you who trample on the needy    and bring the poor of the land to an end,5   saying, “When will the new moon be over,    that we may sell grain?  And the Sabbath,    that we may offer wheat for sale,  that we may make the ephah small and the shekel4 great    and deal deceitfully with false balances,6   that we may buy the poor for silver    and the needy for a pair of sandals    and sell the chaff of the wheat?” 7   The LORD has sworn by the pride of Jacob:  “Surely I will never forget any of their deeds.8   Shall not the land tremble on this account,    and everyone mourn who dwells in it,  and all of it rise like the Nile,    and be tossed about and sink again, like the Nile of Egypt?” 9   “And on that day,” declares the Lord GOD,    “I will make the sun go down at noon    and darken the earth in broad daylight.10   I will turn your feasts into mourning    and all your songs into lamentation;  I will bring sackcloth on every waist    and baldness on every head;  I will make it like the mourning for an only son    and the end of it like a bitter day. 11   “Behold, the days are coming,” declares the Lord GOD,    “when I will send a famine on the land—  not a famine of bread, nor a thirst for water,    but of hearing the words of the LORD.12   They shall wander from sea to sea,    and from north to east;  they shall run to and fro, to seek the word of the LORD,    but they shall not find it. 13   “In that day the lovely virgins and the young men    shall faint for thirst.14   Those who swear by the Guilt of Samaria,    and say, ‘As your god lives, O Dan,'  and, ‘As the Way of Beersheba lives,'    they shall fall, and never rise again.” Footnotes [1] 8:2 The Hebrew words for end and summer fruit sound alike [2] 8:3 Or palace [3] 8:3 Or The singing women of the palace shall wail [4] 8:5 An ephah was about 3/5 bushel or 22 liters; a shekel was about 2/5 ounce or 11 grams (ESV) Luke 3 (Listen) John the Baptist Prepares the Way 3 In the fifteenth year of the reign of Tiberius Caesar, Pontius Pilate being governor of Judea, and Herod being tetrarch of Galilee, and his brother Philip tetrarch of the region of Ituraea and Trachonitis, and Lysanias tetrarch of Abilene, 2 during the high priesthood of Annas and Caiaphas, the word of God came to John the son of Zechariah in the wilderness. 3 And he went into all the region around the Jordan, proclaiming a baptism of repentance for the forgiveness of sins. 4 As it is written in the book of the words of Isaiah the prophet,   “The voice of one crying in the wilderness:  ‘Prepare the way of the Lord,1    make his paths straight.5   Every valley shall be filled,    and every mountain and hill shall be made low,  and the crooked shall become straight,    and the rough places shall become level ways,6   and all flesh shall see the salvation of God.'” 7 He said therefore to the crowds that came out to be baptized by him, “You brood of vipers! Who warned you to flee from the wrath to come? 8 Bear fruits in keeping with repentance. And do not begin to say to yourselves, ‘We have Abraham as our father.' For I tell you, God is able from these stones to raise up children for Abraham. 9 Even now the axe is laid to the root of the trees. Every tree therefore that does not bear good fruit is cut down and thrown into the fire.” 10 And the crowds asked him, “What then shall we do?” 11 And he answered them, “Whoever has two tunics2 is to share with him who has none, and whoever has food is to do likewise.” 12 Tax collectors also came to be baptized and said to him, “Teacher, what shall we do?” 13 And he said to them, “Collect no more than you are authorized to do.” 14 Soldiers also asked him, “And we, what shall we do?” And he said to them, “Do not extort money from anyone by threats or by false accusation, and be content with your wages.” 15 As the people were in expectation, and all were questioning in their hearts concerning John, whether he might be the Christ, 16 John answered them all, saying, “I baptize you with water, but he who is mightier than I is coming, the strap of whose sandals I am not worthy to untie. He will baptize you with the Holy Spirit and fire. 17 His winnowing fork is in his hand, to clear his threshing floor and to gather the wheat into his barn, but the chaff he will burn with unquenchable fire.” 18 So with many other exhortations he preached good news to the people. 19 But Herod the tetrarch, who had been reproved by him for Herodias, his brother's wife, and for all the evil things that Herod had done, 20 added this to them all, that he locked up John in prison. 21 Now when all the people were baptized, and when Jesus also had been baptized and was praying, the heavens were opened, 22 and the Holy Spirit descended on him in bodily form, like a dove; and a voice came from heaven, “You are my beloved Son;3 with you I am well pleased.”4 The Genealogy of Jesus Christ 23 Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, 24 the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, 25 the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, 26 the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, 27 the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel,5 the son of Neri, 28 the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, 29 the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, 30 the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, 31 the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, 32 the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, 33 the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, 34 the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, 35 the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, 36 the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, 37 the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, 38 the son of Enos, the son of Seth, the son of Adam, the son of God. Footnotes [1] 3:4 Or crying, Prepare in the wilderness the way of the Lord [2] 3:11 Greek chiton, a long garment worn under the cloak next to the skin [3] 3:22 Or my Son, my (or the) Beloved [4] 3:22 Some manuscripts beloved Son; today I have begotten you [5] 3:27 Greek Salathiel (ESV)

Episode 154: Heart Failure and GDMTDr. Malave explains the four main medications that are part of the guideline-directed medical therapy of heart failure with reduced ejection fraction. Dr. Arreaza added comments and questions.  Written by Maria Fernanda Malave, MD. Edits by Hector Arreaza, MD.  You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Brief introduction: Heart failure (HF) is a common condition that affects about 23 million people in the world, and it is estimated that 50% of cases are due to heart failure with reduced ejection fraction (HFrEF). It is a major public health concern because of the high morbidity and mortality with a 5-year survival rate of 25% after hospitalization due to HFrEF.In recent years, the management of HFrEF has evolved due to increased evidence in favor of certain medications. Guideline-directed medical therapy (GDMT) is the foundation of medical therapy for these patients, and it is the result of multiple randomized controlled trials and reviews favoring four main drug classes: 1. renin-angiotensin system inhibitors (angiotensin-converting enzyme inhibitors -ACEi- and angiotensin receptor blockers -ARB), 2. evidence-based β-blockers, 3. mineralocorticoid inhibitors, and 4. sodium-glucose cotransporter 2 inhibitors -SGLT-2i-. The benefit of this therapy is mostly seen when these four groups of medications are used in conjunction. During this episode, we will provide some key elements about the prescription of these medications, but this is only an overview, and you are invited to continue learning from reputable sources.Definitions: HF is defined as the impairment of the heart to meet the metabolic demands of the body. It can be caused by multiple conditions that interfere with the filling up of the heart or conditions that prevent an effective ejection of blood out of the heart. Classification of HFrEF: Based on the EF by echocardiogram, heart failure can be classified as:Heart failure with preserved ejection fraction (HFpEF) when the EF is 50% or more.Heart failure with mildly reduced ejection fraction when EF ranges between 41-49%.Heart failure with reduced ejection fraction (HFrEF) when EF is 40% or less.GDMT: Once we make the diagnosis of HF, it is key to educate our patients and re-educate them every single visit about the importance of guideline-directed medical therapy (GDMT) and lifestyle modifications, because this can change the prognosis and exacerbation rates. Many patients think that since they are feeling well after starting GDMT they can stop it, but that's going to increase exacerbations, hospitalizations, and decrease quality of life. Key points to discuss with patients.First, discuss that GDMT are disease-modifying drugs that regulate the neurohormonal system to stop the progression of the disease. We should explain to our patients that medications should be taken despite feeling well. Also, patients should be educated about regular follow-ups and medication titration. We can even instruct our patients about increasing their furosemide dose if they observe signs of overload, such as a weight increase of 2-3 kgs in 3-4 days, tight rings, socks or bracelets, also Paroxysmal nocturnal dyspnea, dyspnea on exertion, and more.  Second, lifestyle modifications such as: quit smoking and alcohol. Additionally, in general, water restriction between 1.2-1.5L daily, salt restriction (there is no official recommendation about how many grams, but in general we recommend less than 2g daily). Third, it is highly recommended to do aerobic exercise that produces mild dyspnea since this improves cardiovascular capacity and decreases hospitalization risk. Patients should be encouraged to have their annual influenza vaccine and pneumococcal vaccine according to their own immunization schedule. According to the AFP journal, in September 2022, researchers found a clinically and statistically significant reduction in all-cause mortality for patients who received an influenza vaccine right after an MI, with a number needed to treat of 50, the effectivity of the vaccine may vary by season.GDMT, groups of medications:What are the basic medications any patient with HF should be on? At least, patients should be on angiotensin receptor blockers ARBs/ACEIs and Beta-blockers. Let's keep in mind that beta-blockers should be given cautiously in cases of exacerbation, but in general low doses are safe. We also have the angiotensin receptor/neprilysin inhibitors (ARNIs), a group of medications whose representative is the combination of sacubitril/valsartan, aka Entresto®. This medication should be the target once ARBs/ACEIs are tolerated. ARBs/ACEIs/ARNIs should be discontinued in the setting of advanced CKD, with a GFR of 30 or less. This applies to other medications used in HF such as SGLT-2 and mineralocorticoid receptor antagonist (MRA, such as spironolactone/eplerenone). Remember that SGLT-2 inhibitors should be started regardless diabetes status, and BB are safe in the setting of CKD. We also have other groups that are considered safe in patients with advanced CKD such as hydralazine/isosorbide dinitrate (combined or not), which are used in African Americans whose BP and HF symptoms do not improve with maximally tolerated dose of ARBs/ACEIs + BB.Ivabradine: Let's not forget about ivabradine, which is an SA node inhibitor like BB. Patients need to meet criteria such as a maximally tolerated dose of beta-blocker, heart rate of a least 70 or more and being on normal sinus rhythm to be started on this medication. Ivabradine does not improve survival as BB do, so even though they are not contraindicated in HF exacerbation, BB are still preferred since ivabradine does not decrease mortality.Titration and follow-ups in the HF management:-ARBs/ACEIs/ARNIs should be titrated approx. Q2 weeks until the maximally tolerated dose is achieved, ARNI should be titrated up Q2-4weeks. With these medications, we should monitor BP, potassium levels and Glomerular Filtration Rate (GFR). -BB can also be titrated up Q2weeks until the maximally tolerated dose is achieved. HR, BP and signs of congestion should be observed in patients on BB. Same for hydralazine/isosorbide, with BP follow-up. -MRA, such as spironolactone/eplerenone, these meds can be added in patients who remain symptomatic despite maximally tolerated doses of “ARBs or ACEIs or ARNIs” plus Beta-blockers. For MRA, potassium level, and GFR should be monitored every 2-3 days after initiation, 7 days after titration, monthly for 3 months, and then Q3 months. To start a patient on MRA, K+ must be lower than 5.Patients with HF should be followed up at least in a 2-week interval either via telephone, telemedicine, or clinic visit to assess symptoms, vital signs, bloodwork and to perform a physical exam. Monitoring EF: After 3-6 months of the patient´s stabilization, we should reorder an echo, EKG, BNP and Basic Metabolic Panel. The ejection fraction improves in all patients after GDMT initiation and compliance, and in some patients, this improvement is very significant, so we need to reassess EF after stabilization. Comorbidities: Also, let´s keep in mind that most of the patients have associated comorbidities such as Afib, diabetes, valve disease, or anemia. These comorbidities must be addressed either by starting anticoagulation, adjusting anti-diabetes medications, starting iron, or referring to cardiology if a valve replacement is needed.When to refer to Cardiology? Some patients will qualify for device therapy (ICD) as a primary prevention for ventricular arrhythmias that can degenerate either into torsades or ventricular fibrillation. These patients must be symptomatic, at least in 3 months of maximally tolerated GDMT, and EF between 30-35%. Symptomatic

Luke 2–3 Luke 2–3 (Listen) The Birth of Jesus Christ 2 In those days a decree went out from Caesar Augustus that all the world should be registered. 2 This was the first registration when1 Quirinius was governor of Syria. 3 And all went to be registered, each to his own town. 4 And Joseph also went up from Galilee, from the town of Nazareth, to Judea, to the city of David, which is called Bethlehem, because he was of the house and lineage of David, 5 to be registered with Mary, his betrothed,2 who was with child. 6 And while they were there, the time came for her to give birth. 7 And she gave birth to her firstborn son and wrapped him in swaddling cloths and laid him in a manger, because there was no place for them in the inn.3 The Shepherds and the Angels 8 And in the same region there were shepherds out in the field, keeping watch over their flock by night. 9 And an angel of the Lord appeared to them, and the glory of the Lord shone around them, and they were filled with great fear. 10 And the angel said to them, “Fear not, for behold, I bring you good news of great joy that will be for all the people. 11 For unto you is born this day in the city of David a Savior, who is Christ the Lord. 12 And this will be a sign for you: you will find a baby wrapped in swaddling cloths and lying in a manger.” 13 And suddenly there was with the angel a multitude of the heavenly host praising God and saying, 14   “Glory to God in the highest,    and on earth peace among those with whom he is pleased!”4 15 When the angels went away from them into heaven, the shepherds said to one another, “Let us go over to Bethlehem and see this thing that has happened, which the Lord has made known to us.” 16 And they went with haste and found Mary and Joseph, and the baby lying in a manger. 17 And when they saw it, they made known the saying that had been told them concerning this child. 18 And all who heard it wondered at what the shepherds told them. 19 But Mary treasured up all these things, pondering them in her heart. 20 And the shepherds returned, glorifying and praising God for all they had heard and seen, as it had been told them. 21 And at the end of eight days, when he was circumcised, he was called Jesus, the name given by the angel before he was conceived in the womb. Jesus Presented at the Temple 22 And when the time came for their purification according to the Law of Moses, they brought him up to Jerusalem to present him to the Lord 23 (as it is written in the Law of the Lord, “Every male who first opens the womb shall be called holy to the Lord”) 24 and to offer a sacrifice according to what is said in the Law of the Lord, “a pair of turtledoves, or two young pigeons.” 25 Now there was a man in Jerusalem, whose name was Simeon, and this man was righteous and devout, waiting for the consolation of Israel, and the Holy Spirit was upon him. 26 And it had been revealed to him by the Holy Spirit that he would not see death before he had seen the Lord's Christ. 27 And he came in the Spirit into the temple, and when the parents brought in the child Jesus, to do for him according to the custom of the Law, 28 he took him up in his arms and blessed God and said, 29   “Lord, now you are letting your servant5 depart in peace,    according to your word;30   for my eyes have seen your salvation31     that you have prepared in the presence of all peoples,32   a light for revelation to the Gentiles,    and for glory to your people Israel.” 33 And his father and his mother marveled at what was said about him. 34 And Simeon blessed them and said to Mary his mother, “Behold, this child is appointed for the fall and rising of many in Israel, and for a sign that is opposed 35 (and a sword will pierce through your own soul also), so that thoughts from many hearts may be revealed.” 36 And there was a prophetess, Anna, the daughter of Phanuel, of the tribe of Asher. She was advanced in years, having lived with her husband seven years from when she was a virgin, 37 and then as a widow until she was eighty-four.6 She did not depart from the temple, worshiping with fasting and prayer night and day. 38 And coming up at that very hour she began to give thanks to God and to speak of him to all who were waiting for the redemption of Jerusalem. The Return to Nazareth 39 And when they had performed everything according to the Law of the Lord, they returned into Galilee, to their own town of Nazareth. 40 And the child grew and became strong, filled with wisdom. And the favor of God was upon him. The Boy Jesus in the Temple 41 Now his parents went to Jerusalem every year at the Feast of the Passover. 42 And when he was twelve years old, they went up according to custom. 43 And when the feast was ended, as they were returning, the boy Jesus stayed behind in Jerusalem. His parents did not know it, 44 but supposing him to be in the group they went a day's journey, but then they began to search for him among their relatives and acquaintances, 45 and when they did not find him, they returned to Jerusalem, searching for him. 46 After three days they found him in the temple, sitting among the teachers, listening to them and asking them questions. 47 And all who heard him were amazed at his understanding and his answers. 48 And when his parents7 saw him, they were astonished. And his mother said to him, “Son, why have you treated us so? Behold, your father and I have been searching for you in great distress.” 49 And he said to them, “Why were you looking for me? Did you not know that I must be in my Father's house?”8 50 And they did not understand the saying that he spoke to them. 51 And he went down with them and came to Nazareth and was submissive to them. And his mother treasured up all these things in her heart. 52 And Jesus increased in wisdom and in stature9 and in favor with God and man. John the Baptist Prepares the Way 3 In the fifteenth year of the reign of Tiberius Caesar, Pontius Pilate being governor of Judea, and Herod being tetrarch of Galilee, and his brother Philip tetrarch of the region of Ituraea and Trachonitis, and Lysanias tetrarch of Abilene, 2 during the high priesthood of Annas and Caiaphas, the word of God came to John the son of Zechariah in the wilderness. 3 And he went into all the region around the Jordan, proclaiming a baptism of repentance for the forgiveness of sins. 4 As it is written in the book of the words of Isaiah the prophet,   “The voice of one crying in the wilderness:  ‘Prepare the way of the Lord,10    make his paths straight.5   Every valley shall be filled,    and every mountain and hill shall be made low,  and the crooked shall become straight,    and the rough places shall become level ways,6   and all flesh shall see the salvation of God.'” 7 He said therefore to the crowds that came out to be baptized by him, “You brood of vipers! Who warned you to flee from the wrath to come? 8 Bear fruits in keeping with repentance. And do not begin to say to yourselves, ‘We have Abraham as our father.' For I tell you, God is able from these stones to raise up children for Abraham. 9 Even now the axe is laid to the root of the trees. Every tree therefore that does not bear good fruit is cut down and thrown into the fire.” 10 And the crowds asked him, “What then shall we do?” 11 And he answered them, “Whoever has two tunics11 is to share with him who has none, and whoever has food is to do likewise.” 12 Tax collectors also came to be baptized and said to him, “Teacher, what shall we do?” 13 And he said to them, “Collect no more than you are authorized to do.” 14 Soldiers also asked him, “And we, what shall we do?” And he said to them, “Do not extort money from anyone by threats or by false accusation, and be content with your wages.” 15 As the people were in expectation, and all were questioning in their hearts concerning John, whether he might be the Christ, 16 John answered them all, saying, “I baptize you with water, but he who is mightier than I is coming, the strap of whose sandals I am not worthy to untie. He will baptize you with the Holy Spirit and fire. 17 His winnowing fork is in his hand, to clear his threshing floor and to gather the wheat into his barn, but the chaff he will burn with unquenchable fire.” 18 So with many other exhortations he preached good news to the people. 19 But Herod the tetrarch, who had been reproved by him for Herodias, his brother's wife, and for all the evil things that Herod had done, 20 added this to them all, that he locked up John in prison. 21 Now when all the people were baptized, and when Jesus also had been baptized and was praying, the heavens were opened, 22 and the Holy Spirit descended on him in bodily form, like a dove; and a voice came from heaven, “You are my beloved Son;12 with you I am well pleased.”13 The Genealogy of Jesus Christ 23 Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, 24 the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, 25 the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, 26 the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, 27 the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel,14 the son of Neri, 28 the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, 29 the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, 30 the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, 31 the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, 32 the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, 33 the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, 34 the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, 35 the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, 36 the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, 37 the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, 38 the son of Enos, the son of Seth, the son of Adam, the son of God. Footnotes [1] 2:2 Or This was the registration before [2] 2:5 That is, one legally pledged to be married [3] 2:7 Or guest room [4] 2:14 Some manuscripts peace, good will among men [5] 2:29 Or bondservant [6] 2:37 Or as a widow for eighty-four years [7] 2:48 Greek they [8] 2:49 Or about my Father's business [9] 2:52 Or years [10] 3:4 Or crying, Prepare in the wilderness the way of the Lord [11] 3:11 Greek chiton, a long garment worn under the cloak next to the skin [12] 3:22 Or my Son, my (or the) Beloved [13] 3:22 Some manuscripts beloved Son; today I have begotten you [14] 3:27 Greek Salathiel (ESV)

Luke 2–3 Luke 2–3 (Listen) The Birth of Jesus Christ 2 In those days a decree went out from Caesar Augustus that all the world should be registered. 2 This was the first registration when1 Quirinius was governor of Syria. 3 And all went to be registered, each to his own town. 4 And Joseph also went up from Galilee, from the town of Nazareth, to Judea, to the city of David, which is called Bethlehem, because he was of the house and lineage of David, 5 to be registered with Mary, his betrothed,2 who was with child. 6 And while they were there, the time came for her to give birth. 7 And she gave birth to her firstborn son and wrapped him in swaddling cloths and laid him in a manger, because there was no place for them in the inn.3 The Shepherds and the Angels 8 And in the same region there were shepherds out in the field, keeping watch over their flock by night. 9 And an angel of the Lord appeared to them, and the glory of the Lord shone around them, and they were filled with great fear. 10 And the angel said to them, “Fear not, for behold, I bring you good news of great joy that will be for all the people. 11 For unto you is born this day in the city of David a Savior, who is Christ the Lord. 12 And this will be a sign for you: you will find a baby wrapped in swaddling cloths and lying in a manger.” 13 And suddenly there was with the angel a multitude of the heavenly host praising God and saying, 14   “Glory to God in the highest,    and on earth peace among those with whom he is pleased!”4 15 When the angels went away from them into heaven, the shepherds said to one another, “Let us go over to Bethlehem and see this thing that has happened, which the Lord has made known to us.” 16 And they went with haste and found Mary and Joseph, and the baby lying in a manger. 17 And when they saw it, they made known the saying that had been told them concerning this child. 18 And all who heard it wondered at what the shepherds told them. 19 But Mary treasured up all these things, pondering them in her heart. 20 And the shepherds returned, glorifying and praising God for all they had heard and seen, as it had been told them. 21 And at the end of eight days, when he was circumcised, he was called Jesus, the name given by the angel before he was conceived in the womb. Jesus Presented at the Temple 22 And when the time came for their purification according to the Law of Moses, they brought him up to Jerusalem to present him to the Lord 23 (as it is written in the Law of the Lord, “Every male who first opens the womb shall be called holy to the Lord”) 24 and to offer a sacrifice according to what is said in the Law of the Lord, “a pair of turtledoves, or two young pigeons.” 25 Now there was a man in Jerusalem, whose name was Simeon, and this man was righteous and devout, waiting for the consolation of Israel, and the Holy Spirit was upon him. 26 And it had been revealed to him by the Holy Spirit that he would not see death before he had seen the Lord's Christ. 27 And he came in the Spirit into the temple, and when the parents brought in the child Jesus, to do for him according to the custom of the Law, 28 he took him up in his arms and blessed God and said, 29   “Lord, now you are letting your servant5 depart in peace,    according to your word;30   for my eyes have seen your salvation31     that you have prepared in the presence of all peoples,32   a light for revelation to the Gentiles,    and for glory to your people Israel.” 33 And his father and his mother marveled at what was said about him. 34 And Simeon blessed them and said to Mary his mother, “Behold, this child is appointed for the fall and rising of many in Israel, and for a sign that is opposed 35 (and a sword will pierce through your own soul also), so that thoughts from many hearts may be revealed.” 36 And there was a prophetess, Anna, the daughter of Phanuel, of the tribe of Asher. She was advanced in years, having lived with her husband seven years from when she was a virgin, 37 and then as a widow until she was eighty-four.6 She did not depart from the temple, worshiping with fasting and prayer night and day. 38 And coming up at that very hour she began to give thanks to God and to speak of him to all who were waiting for the redemption of Jerusalem. The Return to Nazareth 39 And when they had performed everything according to the Law of the Lord, they returned into Galilee, to their own town of Nazareth. 40 And the child grew and became strong, filled with wisdom. And the favor of God was upon him. The Boy Jesus in the Temple 41 Now his parents went to Jerusalem every year at the Feast of the Passover. 42 And when he was twelve years old, they went up according to custom. 43 And when the feast was ended, as they were returning, the boy Jesus stayed behind in Jerusalem. His parents did not know it, 44 but supposing him to be in the group they went a day's journey, but then they began to search for him among their relatives and acquaintances, 45 and when they did not find him, they returned to Jerusalem, searching for him. 46 After three days they found him in the temple, sitting among the teachers, listening to them and asking them questions. 47 And all who heard him were amazed at his understanding and his answers. 48 And when his parents7 saw him, they were astonished. And his mother said to him, “Son, why have you treated us so? Behold, your father and I have been searching for you in great distress.” 49 And he said to them, “Why were you looking for me? Did you not know that I must be in my Father's house?”8 50 And they did not understand the saying that he spoke to them. 51 And he went down with them and came to Nazareth and was submissive to them. And his mother treasured up all these things in her heart. 52 And Jesus increased in wisdom and in stature9 and in favor with God and man. John the Baptist Prepares the Way 3 In the fifteenth year of the reign of Tiberius Caesar, Pontius Pilate being governor of Judea, and Herod being tetrarch of Galilee, and his brother Philip tetrarch of the region of Ituraea and Trachonitis, and Lysanias tetrarch of Abilene, 2 during the high priesthood of Annas and Caiaphas, the word of God came to John the son of Zechariah in the wilderness. 3 And he went into all the region around the Jordan, proclaiming a baptism of repentance for the forgiveness of sins. 4 As it is written in the book of the words of Isaiah the prophet,   “The voice of one crying in the wilderness:  ‘Prepare the way of the Lord,10    make his paths straight.5   Every valley shall be filled,    and every mountain and hill shall be made low,  and the crooked shall become straight,    and the rough places shall become level ways,6   and all flesh shall see the salvation of God.'” 7 He said therefore to the crowds that came out to be baptized by him, “You brood of vipers! Who warned you to flee from the wrath to come? 8 Bear fruits in keeping with repentance. And do not begin to say to yourselves, ‘We have Abraham as our father.' For I tell you, God is able from these stones to raise up children for Abraham. 9 Even now the axe is laid to the root of the trees. Every tree therefore that does not bear good fruit is cut down and thrown into the fire.” 10 And the crowds asked him, “What then shall we do?” 11 And he answered them, “Whoever has two tunics11 is to share with him who has none, and whoever has food is to do likewise.” 12 Tax collectors also came to be baptized and said to him, “Teacher, what shall we do?” 13 And he said to them, “Collect no more than you are authorized to do.” 14 Soldiers also asked him, “And we, what shall we do?” And he said to them, “Do not extort money from anyone by threats or by false accusation, and be content with your wages.” 15 As the people were in expectation, and all were questioning in their hearts concerning John, whether he might be the Christ, 16 John answered them all, saying, “I baptize you with water, but he who is mightier than I is coming, the strap of whose sandals I am not worthy to untie. He will baptize you with the Holy Spirit and fire. 17 His winnowing fork is in his hand, to clear his threshing floor and to gather the wheat into his barn, but the chaff he will burn with unquenchable fire.” 18 So with many other exhortations he preached good news to the people. 19 But Herod the tetrarch, who had been reproved by him for Herodias, his brother's wife, and for all the evil things that Herod had done, 20 added this to them all, that he locked up John in prison. 21 Now when all the people were baptized, and when Jesus also had been baptized and was praying, the heavens were opened, 22 and the Holy Spirit descended on him in bodily form, like a dove; and a voice came from heaven, “You are my beloved Son;12 with you I am well pleased.”13 The Genealogy of Jesus Christ 23 Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, 24 the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, 25 the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, 26 the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, 27 the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel,14 the son of Neri, 28 the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, 29 the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, 30 the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, 31 the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, 32 the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, 33 the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, 34 the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, 35 the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, 36 the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, 37 the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, 38 the son of Enos, the son of Seth, the son of Adam, the son of God. Footnotes [1] 2:2 Or This was the registration before [2] 2:5 That is, one legally pledged to be married [3] 2:7 Or guest room [4] 2:14 Some manuscripts peace, good will among men [5] 2:29 Or bondservant [6] 2:37 Or as a widow for eighty-four years [7] 2:48 Greek they [8] 2:49 Or about my Father's business [9] 2:52 Or years [10] 3:4 Or crying, Prepare in the wilderness the way of the Lord [11] 3:11 Greek chiton, a long garment worn under the cloak next to the skin [12] 3:22 Or my Son, my (or the) Beloved [13] 3:22 Some manuscripts beloved Son; today I have begotten you [14] 3:27 Greek Salathiel (ESV)

The following question refers to Section 7.3 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. The question is asked by Palisades Medical Center medicine resident & CardioNerds Academy Fellow Dr. Maryam Barkhordarian, answered first by Hopkins Bayview medicine resident & CardioNerds Academy Faculty Dr. Ty Sweeny, and then by expert faculty Dr. Gregg Fonarow. Dr. Fonarow is the Professor of Medicine and Interim Chief of UCLA's Division of Cardiology, Director of the Ahmanson-UCLA Cardiomyopathy Center, and Co-director of UCLA's Preventative Cardiology Program. The Decipher the Guidelines: 2022 AHA / ACC / HFSA Guideline for The Management of Heart Failure series was developed by the CardioNerds and created in collaboration with the American Heart Association and the Heart Failure Society of America. It was created by 30 trainees spanning college through advanced fellowship under the leadership of CardioNerds Cofounders Dr. Amit Goyal and Dr. Dan Ambinder, with mentorship from Dr. Anu Lala, Dr. Robert Mentz, and Dr. Nancy Sweitzer. We thank Dr. Judy Bezanson and Dr. Elliott Antman for tremendous guidance. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. Question #28 Mr. Gene D'aMeTi, a 53-year-old African American man with ischemic cardiomyopathy and heart failure with reduced ejection fraction (LVEF 30-35%), is recently admitted with acutely decompensated heart failure and acute kidney injury on chronic kidney disease stage III. His outpatient regiment includes sacubitril-valsartan 97-103mg BID, carvedilol 25mg BID, and hydralazine 50mg TID. Sacubitril-valsartan was held because of worsening renal function. Despite symptomatic improvement with diuresis, his renal function continues to decline. He is otherwise well perfused & with preservation of other end organ function.   Throughout this hospitalization, he has steadily become more hypertensive with blood pressures persisting in the 170s/90s mmHg. What would be an appropriate adjustment to his medication regimen at this time? A Resume Losartan only B Start Amlodipine C Increase current Hydralazine dose D Start Isosorbide dinitrate therapy E Both C & D Answer #28 ExplanationThe correct answer is E – both increasing the current hydralazine dose (C) and starting isosorbide dinitrate therapy (D). Although ACEI/ARB therapy (choice A) has shown a mortality and morbidity benefit in HFrEF, caution should be used in patients with renal insufficiency. In this patient with ongoing decline in renal function, RAAS-inhibiting therapies (ACEi, ARB, ARNI, MRA) should be avoided. In this case, as his RAAS-I has been stopped, it would be reasonable to increase current therapies to target doses (or nearest dose tolerated), as these demonstrated both safety and efficacy in trials (Class 1, LOE A). Considering that his high dose ARNI was stopped, it is unlikely that either hydralazine or isosorbide dinitrate alone, even at maximal doses, would be sufficient to control his blood pressure (Options C and D, respectively). Interestingly, in the original study by Massie et. Al (1977), the decision was made to combine these therapies as the result was thought to be superior to either medication alone. ISDN would provide preload reduction, while Hydralazine would decrease afterload. Consequently, we do not have data looking at the individual benefit of either medication in isolation. In self-identified African Americans with NYHA class III or IV HFrEF already on optimal GDMT, the addition of hydralazine & isosorbide dinitrate is recommended to improve symptoms and reduce mortality and morbidity (Class 1, LOE A). In this case, as the patient has evidence of progressive renal disfunction, we are limited in using traditional RAAS-I, such as ACEI, ARB, or ARNI.

It's Thursday night in a Reykjavík bar. Arni, coming down from a recent loss, is hoping for a good thing. He takes a chance on a bartender's smile, just as a series of strange, bright objects enter the solar system from interstellar space. Narrated by host Matt Gomez. Published in Metaphorosis on 22 September 2023. Find the original at magazine.metaphorosis.com.

Psalms and Wisdom: Psalm 34 Psalm 34 (Listen) Taste and See That the Lord Is Good 1 Of David, when he changed his behavior before Abimelech, so that he drove him out, and he went away. 34   I will bless the LORD at all times;    his praise shall continually be in my mouth.2   My soul makes its boast in the LORD;    let the humble hear and be glad.3   Oh, magnify the LORD with me,    and let us exalt his name together! 4   I sought the LORD, and he answered me    and delivered me from all my fears.5   Those who look to him are radiant,    and their faces shall never be ashamed.6   This poor man cried, and the LORD heard him    and saved him out of all his troubles.7   The angel of the LORD encamps    around those who fear him, and delivers them. 8   Oh, taste and see that the LORD is good!    Blessed is the man who takes refuge in him!9   Oh, fear the LORD, you his saints,    for those who fear him have no lack!10   The young lions suffer want and hunger;    but those who seek the LORD lack no good thing. 11   Come, O children, listen to me;    I will teach you the fear of the LORD.12   What man is there who desires life    and loves many days, that he may see good?13   Keep your tongue from evil    and your lips from speaking deceit.14   Turn away from evil and do good;    seek peace and pursue it. 15   The eyes of the LORD are toward the righteous    and his ears toward their cry.16   The face of the LORD is against those who do evil,    to cut off the memory of them from the earth.17   When the righteous cry for help, the LORD hears    and delivers them out of all their troubles.18   The LORD is near to the brokenhearted    and saves the crushed in spirit. 19   Many are the afflictions of the righteous,    but the LORD delivers him out of them all.20   He keeps all his bones;    not one of them is broken.21   Affliction will slay the wicked,    and those who hate the righteous will be condemned.22   The LORD redeems the life of his servants;    none of those who take refuge in him will be condemned. Footnotes [1] 34:1 This psalm is an acrostic poem, each verse beginning with the successive letters of the Hebrew alphabet (ESV) Pentateuch and History: 1 Samuel 25 1 Samuel 25 (Listen) The Death of Samuel 25 Now Samuel died. And all Israel assembled and mourned for him, and they buried him in his house at Ramah. David and Abigail Then David rose and went down to the wilderness of Paran. 2 And there was a man in Maon whose business was in Carmel. The man was very rich; he had three thousand sheep and a thousand goats. He was shearing his sheep in Carmel. 3 Now the name of the man was Nabal, and the name of his wife Abigail. The woman was discerning and beautiful, but the man was harsh and badly behaved; he was a Calebite. 4 David heard in the wilderness that Nabal was shearing his sheep. 5 So David sent ten young men. And David said to the young men, “Go up to Carmel, and go to Nabal and greet him in my name. 6 And thus you shall greet him: ‘Peace be to you, and peace be to your house, and peace be to all that you have. 7 I hear that you have shearers. Now your shepherds have been with us, and we did them no harm, and they missed nothing all the time they were in Carmel. 8 Ask your young men, and they will tell you. Therefore let my young men find favor in your eyes, for we come on a feast day. Please give whatever you have at hand to your servants and to your son David.'” 9 When David's young men came, they said all this to Nabal in the name of David, and then they waited. 10 And Nabal answered David's servants, “Who is David? Who is the son of Jesse? There are many servants these days who are breaking away from their masters. 11 Shall I take my bread and my water and my meat that I have killed for my shearers and give it to men who come from I do not know where?” 12 So David's young men turned away and came back and told him all this. 13 And David said to his men, “Every man strap on his sword!” And every man of them strapped on his sword. David also strapped on his sword. And about four hundred men went up after David, while two hundred remained with the baggage. 14 But one of the young men told Abigail, Nabal's wife, “Behold, David sent messengers out of the wilderness to greet our master, and he railed at them. 15 Yet the men were very good to us, and we suffered no harm, and we did not miss anything when we were in the fields, as long as we went with them. 16 They were a wall to us both by night and by day, all the while we were with them keeping the sheep. 17 Now therefore know this and consider what you should do, for harm is determined against our master and against all his house, and he is such a worthless man that one cannot speak to him.” 18 Then Abigail made haste and took two hundred loaves and two skins of wine and five sheep already prepared and five seahs1 of parched grain and a hundred clusters of raisins and two hundred cakes of figs, and laid them on donkeys. 19 And she said to her young men, “Go on before me; behold, I come after you.” But she did not tell her husband Nabal. 20 And as she rode on the donkey and came down under cover of the mountain, behold, David and his men came down toward her, and she met them. 21 Now David had said, “Surely in vain have I guarded all that this fellow has in the wilderness, so that nothing was missed of all that belonged to him, and he has returned me evil for good. 22 God do so to the enemies of David2 and more also, if by morning I leave so much as one male of all who belong to him.” 23 When Abigail saw David, she hurried and got down from the donkey and fell before David on her face and bowed to the ground. 24 She fell at his feet and said, “On me alone, my lord, be the guilt. Please let your servant speak in your ears, and hear the words of your servant. 25 Let not my lord regard this worthless fellow, Nabal, for as his name is, so is he. Nabal3 is his name, and folly is with him. But I your servant did not see the young men of my lord, whom you sent. 26 Now then, my lord, as the LORD lives, and as your soul lives, because the LORD has restrained you from bloodguilt and from saving with your own hand, now then let your enemies and those who seek to do evil to my lord be as Nabal. 27 And now let this present that your servant has brought to my lord be given to the young men who follow my lord. 28 Please forgive the trespass of your servant. For the LORD will certainly make my lord a sure house, because my lord is fighting the battles of the LORD, and evil shall not be found in you so long as you live. 29 If men rise up to pursue you and to seek your life, the life of my lord shall be bound in the bundle of the living in the care of the LORD your God. And the lives of your enemies he shall sling out as from the hollow of a sling. 30 And when the LORD has done to my lord according to all the good that he has spoken concerning you and has appointed you prince4 over Israel, 31 my lord shall have no cause of grief or pangs of conscience for having shed blood without cause or for my lord working salvation himself. And when the LORD has dealt well with my lord, then remember your servant.” 32 And David said to Abigail, “Blessed be the LORD, the God of Israel, who sent you this day to meet me! 33 Blessed be your discretion, and blessed be you, who have kept me this day from bloodguilt and from working salvation with my own hand! 34 For as surely as the LORD, the God of Israel, lives, who has restrained me from hurting you, unless you had hurried and come to meet me, truly by morning there had not been left to Nabal so much as one male.” 35 Then David received from her hand what she had brought him. And he said to her, “Go up in peace to your house. See, I have obeyed your voice, and I have granted your petition.” 36 And Abigail came to Nabal, and behold, he was holding a feast in his house, like the feast of a king. And Nabal's heart was merry within him, for he was very drunk. So she told him nothing at all until the morning light. 37 In the morning, when the wine had gone out of Nabal, his wife told him these things, and his heart died within him, and he became as a stone. 38 And about ten days later the LORD struck Nabal, and he died. 39 When David heard that Nabal was dead, he said, “Blessed be the LORD who has avenged the insult I received at the hand of Nabal, and has kept back his servant from wrongdoing. The LORD has returned the evil of Nabal on his own head.” Then David sent and spoke to Abigail, to take her as his wife. 40 When the servants of David came to Abigail at Carmel, they said to her, “David has sent us to you to take you to him as his wife.” 41 And she rose and bowed with her face to the ground and said, “Behold, your handmaid is a servant to wash the feet of the servants of my lord.” 42 And Abigail hurried and rose and mounted a donkey, and her five young women attended her. She followed the messengers of David and became his wife. 43 David also took Ahinoam of Jezreel, and both of them became his wives. 44 Saul had given Michal his daughter, David's wife, to Palti the son of Laish, who was of Gallim. Footnotes [1] 25:18 A seah was about 7 quarts or 7.3 liters [2] 25:22 Septuagint to David [3] 25:25 Nabal means fool [4] 25:30 Or leader (ESV) Chronicles and Prophets: Daniel 6 Daniel 6 (Listen) Daniel and the Lions' Den 6 It pleased Darius to set over the kingdom 120 satraps, to be throughout the whole kingdom; 2 and over them three high officials, of whom Daniel was one, to whom these satraps should give account, so that the king might suffer no loss. 3 Then this Daniel became distinguished above all the other high officials and satraps, because an excellent spirit was in him. And the king planned to set him over the whole kingdom. 4 Then the high officials and the satraps sought to find a ground for complaint against Daniel with regard to the kingdom, but they could find no ground for complaint or any fault, because he was faithful, and no error or fault was found in him. 5 Then these men said, “We shall not find any ground for complaint against this Daniel unless we find it in connection with the law of his God.” 6 Then these high officials and satraps came by agreement1 to the king and said to him, “O King Darius, live forever! 7 All the high officials of the kingdom, the prefects and the satraps, the counselors and the governors are agreed that the king should establish an ordinance and enforce an injunction, that whoever makes petition to any god or man for thirty days, except to you, O king, shall be cast into the den of lions. 8 Now, O king, establish the injunction and sign the document, so that it cannot be changed, according to the law of the Medes and the Persians, which cannot be revoked.” 9 Therefore King Darius signed the document and injunction. 10 When Daniel knew that the document had been signed, he went to his house where he had windows in his upper chamber open toward Jerusalem. He got down on his knees three times a day and prayed and gave thanks before his God, as he had done previously. 11 Then these men came by agreement and found Daniel making petition and plea before his God. 12 Then they came near and said before the king, concerning the injunction, “O king! Did you not sign an injunction, that anyone who makes petition to any god or man within thirty days except to you, O king, shall be cast into the den of lions?” The king answered and said, “The thing stands fast, according to the law of the Medes and Persians, which cannot be revoked.” 13 Then they answered and said before the king, “Daniel, who is one of the exiles from Judah, pays no attention to you, O king, or the injunction you have signed, but makes his petition three times a day.” 14 Then the king, when he heard these words, was much distressed and set his mind to deliver Daniel. And he labored till the sun went down to rescue him. 15 Then these men came by agreement to the king and said to the king, “Know, O king, that it is a law of the Medes and Persians that no injunction or ordinance that the king establishes can be changed.” 16 Then the king commanded, and Daniel was brought and cast into the den of lions. The king declared2 to Daniel, “May your God, whom you serve continually, deliver you!” 17 And a stone was brought and laid on the mouth of the den, and the king sealed it with his own signet and with the signet of his lords, that nothing might be changed concerning Daniel. 18 Then the king went to his palace and spent the night fasting; no diversions were brought to him, and sleep fled from him. 19 Then, at break of day, the king arose and went in haste to the den of lions. 20 As he came near to the den where Daniel was, he cried out in a tone of anguish. The king declared to Daniel, “O Daniel, servant of the living God, has your God, whom you serve continually, been able to deliver you from the lions?” 21 Then Daniel said to the king, “O king, live forever! 22 My God sent his angel and shut the lions' mouths, and they have not harmed me, because I was found blameless before him; and also before you, O king, I have done no harm.” 23 Then the king was exceedingly glad, and commanded that Daniel be taken up out of the den. So Daniel was taken up out of the den, and no kind of harm was found on him, because he had trusted in his God. 24 And the king commanded, and those men who had maliciously accused Daniel were brought and cast into the den of lions—they, their children, and their wives. And before they reached the bottom of the den, the lions overpowered them and broke all their bones in pieces. 25 Then King Darius wrote to all the peoples, nations, and languages that dwell in all the earth: “Peace be multiplied to you. 26 I make a decree, that in all my royal dominion people are to tremble and fear before the God of Daniel,   for he is the living God,    enduring forever;  his kingdom shall never be destroyed,    and his dominion shall be to the end.27   He delivers and rescues;    he works signs and wonders    in heaven and on earth,  he who has saved Daniel    from the power of the lions.” 28 So this Daniel prospered during the reign of Darius and the reign of Cyrus the Persian. Footnotes [1] 6:6 Or came thronging; also verses 11, 15 [2] 6:16 Aramaic answered and said; also verse 20 (ESV) Gospels and Epistles: Luke 3:23–4:13 Luke 3:23–4:13 (Listen) The Genealogy of Jesus Christ 23 Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, 24 the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, 25 the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, 26 the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, 27 the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel,1 the son of Neri, 28 the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, 29 the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, 30 the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, 31 the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, 32 the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, 33 the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, 34 the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, 35 the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, 36 the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, 37 the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, 38 the son of Enos, the son of Seth, the son of Adam, the son of God. The Temptation of Jesus 4 And Jesus, full of the Holy Spirit, returned from the Jordan and was led by the Spirit in the wilderness 2 for forty days, being tempted by the devil. And he ate nothing during those days. And when they were ended, he was hungry. 3 The devil said to him, “If you are the Son of God, command this stone to become bread.” 4 And Jesus answered him, “It is written, ‘Man shall not live by bread alone.'” 5 And the devil took him up and showed him all the kingdoms of the world in a moment of time, 6 and said to him, “To you I will give all this authority and their glory, for it has been delivered to me, and I give it to whom I will. 7 If you, then, will worship me, it will all be yours.” 8 And Jesus answered him, “It is written,   “‘You shall worship the Lord your God,    and him only shall you serve.'” 9 And he took him to Jerusalem and set him on the pinnacle of the temple and said to him, “If you are the Son of God, throw yourself down from here, 10 for it is written,   “‘He will command his angels concerning you,    to guard you,' 11 and   “‘On their hands they will bear you up,    lest you strike your foot against a stone.'” 12 And Jesus answered him, “It is said, ‘You shall not put the Lord your God to the test.'” 13 And when the devil had ended every temptation, he departed from him until an opportune time. Footnotes [1] 3:27 Greek Salathiel (ESV)

Boilermaker Hall-of-Fame member Billy Keller shares his experiences as a Boilermaker legendary basketball player (1967-69) on this 76th birthday (August 30, 2023). Keller, the only Boilermaker to experience Purdue's two final four appearances as a player (1969) and as an (assistant coach, 1980), shares his experiences about his successful basketball life. Keller's remarkable basketball career included a state title in Indianapolis, Washington H.S.(1965) and being named Indiana Mr. Basketball later that same year. In college, he was a three-year starter for coach George King and was the point guard on coach George King's 1969 Final Four Team. Professionally, Keller was a key cog in the Indiana Pacers' three ABA titles in the early 1970s. One of the most beloved figures in the history of basketball in the state of Indiana, Keller continued his basketball life coaching in college at Indiana Central (now UIndy), working for the Indiana Pacers and hosting basketball camps.  During the warmer months in Indiana, he and his wife Joyce follow their four grandchildren's athletic exploits. His two granddaughters play college volleyball in Ohio (Dayton and Marietta), one of his grandsons, Luke Almodovar, was a guard on the Indiana All-Star team and the other is a basketball player as well and is considering attending Purdue in engineering after this year.  "I have been very fortunate, but it has given me so many great memories," Keller said.   

We celebrate birthday No. 100 (Aug. 17, 2023) with arguably Purdue's oldest living Knucklehead, GoldandBlack.com subscriber Howell Wheaton celebrated his 100th birthday on Thursday (August 17, 2023) and we caught up with him for a Arni's Birthday Zoom from his Missouri home.

Old Testament: Nehemiah 12–13 Nehemiah 12–13 (Listen) Priests and Levites 12 These are the priests and the Levites who came up with Zerubbabel the son of Shealtiel, and Jeshua: Seraiah, Jeremiah, Ezra, 2 Amariah, Malluch, Hattush, 3 Shecaniah, Rehum, Meremoth, 4 Iddo, Ginnethoi, Abijah, 5 Mijamin, Maadiah, Bilgah, 6 Shemaiah, Joiarib, Jedaiah, 7 Sallu, Amok, Hilkiah, Jedaiah. These were the chiefs of the priests and of their brothers in the days of Jeshua. 8 And the Levites: Jeshua, Binnui, Kadmiel, Sherebiah, Judah, and Mattaniah, who with his brothers was in charge of the songs of thanksgiving. 9 And Bakbukiah and Unni and their brothers stood opposite them in the service. 10 And Jeshua was the father of Joiakim, Joiakim the father of Eliashib, Eliashib the father of Joiada, 11 Joiada the father of Jonathan, and Jonathan the father of Jaddua. 12 And in the days of Joiakim were priests, heads of fathers' houses: of Seraiah, Meraiah; of Jeremiah, Hananiah; 13 of Ezra, Meshullam; of Amariah, Jehohanan; 14 of Malluchi, Jonathan; of Shebaniah, Joseph; 15 of Harim, Adna; of Meraioth, Helkai; 16 of Iddo, Zechariah; of Ginnethon, Meshullam; 17 of Abijah, Zichri; of Miniamin, of Moadiah, Piltai; 18 of Bilgah, Shammua; of Shemaiah, Jehonathan; 19 of Joiarib, Mattenai; of Jedaiah, Uzzi; 20 of Sallai, Kallai; of Amok, Eber; 21 of Hilkiah, Hashabiah; of Jedaiah, Nethanel. 22 In the days of Eliashib, Joiada, Johanan, and Jaddua, the Levites were recorded as heads of fathers' houses; so too were the priests in the reign of Darius the Persian. 23 As for the sons of Levi, their heads of fathers' houses were written in the Book of the Chronicles until the days of Johanan the son of Eliashib. 24 And the chiefs of the Levites: Hashabiah, Sherebiah, and Jeshua the son of Kadmiel, with their brothers who stood opposite them, to praise and to give thanks, according to the commandment of David the man of God, watch by watch. 25 Mattaniah, Bakbukiah, Obadiah, Meshullam, Talmon, and Akkub were gatekeepers standing guard at the storehouses of the gates. 26 These were in the days of Joiakim the son of Jeshua son of Jozadak, and in the days of Nehemiah the governor and of Ezra, the priest and scribe. Dedication of the Wall 27 And at the dedication of the wall of Jerusalem they sought the Levites in all their places, to bring them to Jerusalem to celebrate the dedication with gladness, with thanksgivings and with singing, with cymbals, harps, and lyres. 28 And the sons of the singers gathered together from the district surrounding Jerusalem and from the villages of the Netophathites; 29 also from Beth-gilgal and from the region of Geba and Azmaveth, for the singers had built for themselves villages around Jerusalem. 30 And the priests and the Levites purified themselves, and they purified the people and the gates and the wall. 31 Then I brought the leaders of Judah up onto the wall and appointed two great choirs that gave thanks. One went to the south on the wall to the Dung Gate. 32 And after them went Hoshaiah and half of the leaders of Judah, 33 and Azariah, Ezra, Meshullam, 34 Judah, Benjamin, Shemaiah, and Jeremiah, 35 and certain of the priests' sons with trumpets: Zechariah the son of Jonathan, son of Shemaiah, son of Mattaniah, son of Micaiah, son of Zaccur, son of Asaph; 36 and his relatives, Shemaiah, Azarel, Milalai, Gilalai, Maai, Nethanel, Judah, and Hanani, with the musical instruments of David the man of God. And Ezra the scribe went before them. 37 At the Fountain Gate they went up straight before them by the stairs of the city of David, at the ascent of the wall, above the house of David, to the Water Gate on the east. 38 The other choir of those who gave thanks went to the north, and I followed them with half of the people, on the wall, above the Tower of the Ovens, to the Broad Wall, 39 and above the Gate of Ephraim, and by the Gate of Yeshanah,1 and by the Fish Gate and the Tower of Hananel and the Tower of the Hundred, to the Sheep Gate; and they came to a halt at the Gate of the Guard. 40 So both choirs of those who gave thanks stood in the house of God, and I and half of the officials with me; 41 and the priests Eliakim, Maaseiah, Miniamin, Micaiah, Elioenai, Zechariah, and Hananiah, with trumpets; 42 and Maaseiah, Shemaiah, Eleazar, Uzzi, Jehohanan, Malchijah, Elam, and Ezer. And the singers sang with Jezrahiah as their leader. 43 And they offered great sacrifices that day and rejoiced, for God had made them rejoice with great joy; the women and children also rejoiced. And the joy of Jerusalem was heard far away. Service at the Temple 44 On that day men were appointed over the storerooms, the contributions, the firstfruits, and the tithes, to gather into them the portions required by the Law for the priests and for the Levites according to the fields of the towns, for Judah rejoiced over the priests and the Levites who ministered. 45 And they performed the service of their God and the service of purification, as did the singers and the gatekeepers, according to the command of David and his son Solomon. 46 For long ago in the days of David and Asaph there were directors of the singers, and there were songs2 of praise and thanksgiving to God. 47 And all Israel in the days of Zerubbabel and in the days of Nehemiah gave the daily portions for the singers and the gatekeepers; and they set apart that which was for the Levites; and the Levites set apart that which was for the sons of Aaron. Nehemiah's Final Reforms 13 On that day they read from the Book of Moses in the hearing of the people. And in it was found written that no Ammonite or Moabite should ever enter the assembly of God, 2 for they did not meet the people of Israel with bread and water, but hired Balaam against them to curse them—yet our God turned the curse into a blessing. 3 As soon as the people heard the law, they separated from Israel all those of foreign descent. 4 Now before this, Eliashib the priest, who was appointed over the chambers of the house of our God, and who was related to Tobiah, 5 prepared for Tobiah a large chamber where they had previously put the grain offering, the frankincense, the vessels, and the tithes of grain, wine, and oil, which were given by commandment to the Levites, singers, and gatekeepers, and the contributions for the priests. 6 While this was taking place, I was not in Jerusalem, for in the thirty-second year of Artaxerxes king of Babylon I went to the king. And after some time I asked leave of the king 7 and came to Jerusalem, and I then discovered the evil that Eliashib had done for Tobiah, preparing for him a chamber in the courts of the house of God. 8 And I was very angry, and I threw all the household furniture of Tobiah out of the chamber. 9 Then I gave orders, and they cleansed the chambers, and I brought back there the vessels of the house of God, with the grain offering and the frankincense. 10 I also found out that the portions of the Levites had not been given to them, so that the Levites and the singers, who did the work, had fled each to his field. 11 So I confronted the officials and said, “Why is the house of God forsaken?” And I gathered them together and set them in their stations. 12 Then all Judah brought the tithe of the grain, wine, and oil into the storehouses. 13 And I appointed as treasurers over the storehouses Shelemiah the priest, Zadok the scribe, and Pedaiah of the Levites, and as their assistant Hanan the son of Zaccur, son of Mattaniah, for they were considered reliable, and their duty was to distribute to their brothers. 14 Remember me, O my God, concerning this, and do not wipe out my good deeds that I have done for the house of my God and for his service. 15 In those days I saw in Judah people treading winepresses on the Sabbath, and bringing in heaps of grain and loading them on donkeys, and also wine, grapes, figs, and all kinds of loads, which they brought into Jerusalem on the Sabbath day. And I warned them on the day when they sold food. 16 Tyrians also, who lived in the city, brought in fish and all kinds of goods and sold them on the Sabbath to the people of Judah, in Jerusalem itself! 17 Then I confronted the nobles of Judah and said to them, “What is this evil thing that you are doing, profaning the Sabbath day? 18 Did not your fathers act in this way, and did not our God bring all this disaster3 on us and on this city? Now you are bringing more wrath on Israel by profaning the Sabbath.” 19 As soon as it began to grow dark at the gates of Jerusalem before the Sabbath, I commanded that the doors should be shut and gave orders that they should not be opened until after the Sabbath. And I stationed some of my servants at the gates, that no load might be brought in on the Sabbath day. 20 Then the merchants and sellers of all kinds of wares lodged outside Jerusalem once or twice. 21 But I warned them and said to them, “Why do you lodge outside the wall? If you do so again, I will lay hands on you.” From that time on they did not come on the Sabbath. 22 Then I commanded the Levites that they should purify themselves and come and guard the gates, to keep the Sabbath day holy. Remember this also in my favor, O my God, and spare me according to the greatness of your steadfast love. 23 In those days also I saw the Jews who had married women of Ashdod, Ammon, and Moab. 24 And half of their children spoke the language of Ashdod, and they could not speak the language of Judah, but only the language of each people. 25 And I confronted them and cursed them and beat some of them and pulled out their hair. And I made them take an oath in the name of God, saying, “You shall not give your daughters to their sons, or take their daughters for your sons or for yourselves. 26 Did not Solomon king of Israel sin on account of such women? Among the many nations there was no king like him, and he was beloved by his God, and God made him king over all Israel. Nevertheless, foreign women made even him to sin. 27 Shall we then listen to you and do all this great evil and act treacherously against our God by marrying foreign women?” 28 And one of the sons of Jehoiada, the son of Eliashib the high priest, was the son-in-law of Sanballat the Horonite. Therefore I chased him from me. 29 Remember them, O my God, because they have desecrated the priesthood and the covenant of the priesthood and the Levites. 30 Thus I cleansed them from everything foreign, and I established the duties of the priests and Levites, each in his work; 31 and I provided for the wood offering at appointed times, and for the firstfruits. Remember me, O my God, for good. Footnotes [1] 12:39 Or of the old city [2] 12:46 Or leaders [3] 13:18 The Hebrew word can mean evil, harm, or disaster, depending on the context (ESV) Psalm: Psalm 39 Psalm 39 (Listen) What Is the Measure of My Days? To the choirmaster: to Jeduthun. A Psalm of David. 39   I said, “I will guard my ways,    that I may not sin with my tongue;  I will guard my mouth with a muzzle,    so long as the wicked are in my presence.”2   I was mute and silent;    I held my peace to no avail,  and my distress grew worse.3     My heart became hot within me.  As I mused, the fire burned;    then I spoke with my tongue: 4   “O LORD, make me know my end    and what is the measure of my days;    let me know how fleeting I am!5   Behold, you have made my days a few handbreadths,    and my lifetime is as nothing before you.  Surely all mankind stands as a mere breath! Selah6     Surely a man goes about as a shadow!  Surely for nothing1 they are in turmoil;    man heaps up wealth and does not know who will gather! 7   “And now, O Lord, for what do I wait?    My hope is in you.8   Deliver me from all my transgressions.    Do not make me the scorn of the fool!9   I am mute; I do not open my mouth,    for it is you who have done it.10   Remove your stroke from me;    I am spent by the hostility of your hand.11   When you discipline a man    with rebukes for sin,  you consume like a moth what is dear to him;    surely all mankind is a mere breath! Selah 12   “Hear my prayer, O LORD,    and give ear to my cry;    hold not your peace at my tears!  For I am a sojourner with you,    a guest, like all my fathers.13   Look away from me, that I may smile again,    before I depart and am no more!” Footnotes [1] 39:6 Hebrew Surely as a breath (ESV) New Testament: Luke 3 Luke 3 (Listen) John the Baptist Prepares the Way 3 In the fifteenth year of the reign of Tiberius Caesar, Pontius Pilate being governor of Judea, and Herod being tetrarch of Galilee, and his brother Philip tetrarch of the region of Ituraea and Trachonitis, and Lysanias tetrarch of Abilene, 2 during the high priesthood of Annas and Caiaphas, the word of God came to John the son of Zechariah in the wilderness. 3 And he went into all the region around the Jordan, proclaiming a baptism of repentance for the forgiveness of sins. 4 As it is written in the book of the words of Isaiah the prophet,   “The voice of one crying in the wilderness:  ‘Prepare the way of the Lord,1    make his paths straight.5   Every valley shall be filled,    and every mountain and hill shall be made low,  and the crooked shall become straight,    and the rough places shall become level ways,6   and all flesh shall see the salvation of God.'” 7 He said therefore to the crowds that came out to be baptized by him, “You brood of vipers! Who warned you to flee from the wrath to come? 8 Bear fruits in keeping with repentance. And do not begin to say to yourselves, ‘We have Abraham as our father.' For I tell you, God is able from these stones to raise up children for Abraham. 9 Even now the axe is laid to the root of the trees. Every tree therefore that does not bear good fruit is cut down and thrown into the fire.” 10 And the crowds asked him, “What then shall we do?” 11 And he answered them, “Whoever has two tunics2 is to share with him who has none, and whoever has food is to do likewise.” 12 Tax collectors also came to be baptized and said to him, “Teacher, what shall we do?” 13 And he said to them, “Collect no more than you are authorized to do.” 14 Soldiers also asked him, “And we, what shall we do?” And he said to them, “Do not extort money from anyone by threats or by false accusation, and be content with your wages.” 15 As the people were in expectation, and all were questioning in their hearts concerning John, whether he might be the Christ, 16 John answered them all, saying, “I baptize you with water, but he who is mightier than I is coming, the strap of whose sandals I am not worthy to untie. He will baptize you with the Holy Spirit and fire. 17 His winnowing fork is in his hand, to clear his threshing floor and to gather the wheat into his barn, but the chaff he will burn with unquenchable fire.” 18 So with many other exhortations he preached good news to the people. 19 But Herod the tetrarch, who had been reproved by him for Herodias, his brother's wife, and for all the evil things that Herod had done, 20 added this to them all, that he locked up John in prison. 21 Now when all the people were baptized, and when Jesus also had been baptized and was praying, the heavens were opened, 22 and the Holy Spirit descended on him in bodily form, like a dove; and a voice came from heaven, “You are my beloved Son;3 with you I am well pleased.”4 The Genealogy of Jesus Christ 23 Jesus, when he began his ministry, was about thirty years of age, being the son (as was supposed) of Joseph, the son of Heli, 24 the son of Matthat, the son of Levi, the son of Melchi, the son of Jannai, the son of Joseph, 25 the son of Mattathias, the son of Amos, the son of Nahum, the son of Esli, the son of Naggai, 26 the son of Maath, the son of Mattathias, the son of Semein, the son of Josech, the son of Joda, 27 the son of Joanan, the son of Rhesa, the son of Zerubbabel, the son of Shealtiel,5 the son of Neri, 28 the son of Melchi, the son of Addi, the son of Cosam, the son of Elmadam, the son of Er, 29 the son of Joshua, the son of Eliezer, the son of Jorim, the son of Matthat, the son of Levi, 30 the son of Simeon, the son of Judah, the son of Joseph, the son of Jonam, the son of Eliakim, 31 the son of Melea, the son of Menna, the son of Mattatha, the son of Nathan, the son of David, 32 the son of Jesse, the son of Obed, the son of Boaz, the son of Sala, the son of Nahshon, 33 the son of Amminadab, the son of Admin, the son of Arni, the son of Hezron, the son of Perez, the son of Judah, 34 the son of Jacob, the son of Isaac, the son of Abraham, the son of Terah, the son of Nahor, 35 the son of Serug, the son of Reu, the son of Peleg, the son of Eber, the son of Shelah, 36 the son of Cainan, the son of Arphaxad, the son of Shem, the son of Noah, the son of Lamech, 37 the son of Methuselah, the son of Enoch, the son of Jared, the son of Mahalaleel, the son of Cainan, 38 the son of Enos, the son of Seth, the son of Adam, the son of God. Footnotes [1] 3:4 Or crying, Prepare in the wilderness the way of the Lord [2] 3:11 Greek chiton, a long garment worn under the cloak next to the skin [3] 3:22 Or my Son, my (or the) Beloved [4] 3:22 Some manuscripts beloved Son; today I have begotten you [5] 3:27 Greek Salathiel (ESV)

We celebrate birthday No. 64 (July 31, 2023) with former Purdue running back Ben McCall, the Chicago native that played a key role in the Boilermaker backfield during its three-straight bowl championship seasons under coach Jim Young (1978-80).

We celebrate birthday No. 32 (July 13, 2023) with former Purdue standout guard Terone Johnson who played for coach Matt Painter from 2011-14 earning third-team All-Big Ten honors and playing a major role in two NCAA appearances. Johnson, a tough-minded physical guard, appeared in 134 games as a Boilermakers, ranking ninth all-time in school annals. The Indianapolis native averaged 9.8 points per game and averaged 13.5 and 12.0 points over his final two seasons.

The following question refers to Section 7.6 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.The question is asked by premedical student and CardioNerds Intern Pacey Wetstein, answered first by Mayo Clinic Cardiology Fellow and CardioNerds Academy Chief Dr. Teodora Donisan, and then by expert faculty Dr. Nancy Sweitzer.Dr. Sweitzer is Professor of Medicine, Vice Chair of Clinical Research for the Department of Medicine, and Director of Clinical Research for the Division of Cardiology at Washington University School of Medicine. She is the editor-in-chief of Circulation: Heart Failure. Dr. Sweitzer is a faculty mentor for this Decipher the HF Guidelines series.The Decipher the Guidelines: 2022 AHA / ACC / HFSA Guideline for The Management of Heart Failure series was developed by the CardioNerds and created in collaboration with the American Heart Association and the Heart Failure Society of America. It was created by 30 trainees spanning college through advanced fellowship under the leadership of CardioNerds Cofounders Dr. Amit Goyal and Dr. Dan Ambinder, with mentorship from Dr. Anu Lala, Dr. Robert Mentz, and Dr. Nancy Sweitzer. We thank Dr. Judy Bezanson and Dr. Elliott Antman for tremendous guidance.Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. /*! elementor - v3.13.3 - 28-05-2023 */ .elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}Clinical Trials Talks Question #21 Ms. Betty Blocker is a 60-year-old woman with a history of alcohol-related dilated cardiomyopathy who presents for follow up. She has been working hard to improve her health and is glad to report that she has just reached her 5-year sobriety milestone. Her current medications include metoprolol succinate 100mg daily, sacubitril-valsartan 97-103mg BID, spironolactone 25mg daily, and empagliflozin 10mg daily. She is asymptomatic at rest and up to moderate exercise, including chasing her grandchildren around the yard. A recent transthoracic echocardiogram shows recovered LVEF from previously 35% now to 60%. Ms. Blocker does not love taking so many medications and asks about discontinuing her metoprolol. Which of the following is the most appropriate response to Ms. Blocker's request? A Since the patient is asymptomatic, metoprolol can be stopped without risk B Stopping metoprolol increases this patient's risk of worsening cardiomyopathy regardless of current LVEF or symptoms C Because the LVEF is now >50%, the patient is now classified as having HFpEF and beta-blockade is no longer indicated; metoprolol can be safely discontinued D Metoprolol should be continued, but it is safe to discontinue either ARNi or spironolactone Answer #21 Explanation The correct answer is D – continue current therapy. The patient described above was initially diagnosed with HFrEF and experienced significant symptomatic improvement with GDMT, so she now has heart failure with improved ejection fraction (HFimpEF). In patients with HFimpEF after treatment, GDMT should be continued to prevent relapse of HF and LV dysfunction, even in patients who may become asymptomatic (Class 1, LOE B-R). Although symptoms, functional capacity, LVEF and reverse remodeling can improve with GDMT,

The following question refers to Sections 7.3.2, 7.3.8, and 7.6.2 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. The question is asked by Palisades Medical Center medicine resident & CardioNerds Intern Dr. Maryam Barkhordarian, answered first by Hopkins Bayview medicine resident & CardioNerds Academy Fellow Dr. Ty Sweeny, and then by expert faculty Dr. Robert Mentz. Dr. Mentz is associate professor of medicine and section chief for Heart Failure at Duke University, a clinical researcher at the Duke Clinical Research Institute, and editor-in-chief of the Journal of Cardiac Failure. Dr. Mentz is a mentor for the CardioNerds Clinical Trials Network as lead principal investigator for PARAGLIDE-HF and is a series mentor for this very Decipher the Guidelines Series. For these reasons and many more, he was awarded the Master CardioNerd Award during ACC22. The Decipher the Guidelines: 2022 AHA / ACC / HFSA Guideline for The Management of Heart Failure series was developed by the CardioNerds and created in collaboration with the American Heart Association and the Heart Failure Society of America. It was created by 30 trainees spanning college through advanced fellowship under the leadership of CardioNerds Cofounders Dr. Amit Goyal and Dr. Dan Ambinder, with mentorship from Dr. Anu Lala, Dr. Robert Mentz, and Dr. Nancy Sweitzer. We thank Dr. Judy Bezanson and Dr. Elliott Antman for tremendous guidance. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. Question #20 Ms. Betty Blocker is a 60-year-old woman with a history of alcohol-related dilated cardiomyopathy who presents for follow up. She has been working hard to improve her health and is glad to report that she has just reached her 5-year sobriety milestone. Her current medications include metoprolol succinate 100mg daily, sacubitril-valsartan 97-103mg BID, spironolactone 25mg daily, and empagliflozin 10mg daily. She is asymptomatic at rest and up to moderate exercise, including chasing her grandchildren around the yard. A recent transthoracic echocardiogram shows recovered LVEF from previously 35% now to 60%. Ms. Blocker does not love taking so many medications and asks about discontinuing her metoprolol. Which of the following is the most appropriate response to Ms. Blocker's request? A Since the patient is asymptomatic, metoprolol can be stopped without risk B Stopping metoprolol increases this patient's risk of worsening cardiomyopathy regardless of current LVEF or symptoms C Because the LVEF is now >50%, the patient is now classified as having HFpEF and beta-blockade is no longer indicated; metoprolol can be safely discontinued D Metoprolol should be continued, but it is safe to discontinue either ARNi or spironolactone Answer #20 Explanation The correct answer is B – stopping metoprolol would increase her risk of worsening cardiomyopathy. Heart failure tends to be a chronically sympathetic state. The use of beta-blockers (specifically bisoprolol, metoprolol succinate, and carvedilol) targets this excess adrenergic output and has been shown to reduce the risk of death in patients with HFrEF. Beyond their mortality benefit, beta-blockers can improve LVEF, lessen the symptoms of HF, and improve clinical status. Therefore, in patients with HFrEF, with current or previous symptoms, use of 1 of the 3 beta blockers proven to reduce mortality (e.g., bisoprolol, carvedilol, sustained-release metoprolol succinate) is recommended to reduce mortality and hospitalizations (Class 1, LOE A). Beta-blockers in this setting provide a high economic value. Table 14 of the guidelines provides recommendations for target doses for GDMT medications. Specifically for beta blockers, those targets are 25-50mg twice daily for carvedilol (or 80mg once daily for the continuous release formulation), 200mg once daily for metoprolol succinate,