Podcasts about morphological

Episode #86 of the PhysioBib Podcast is the first in a series of three episodes on pelvic health. In which we had the honor to speak with Professor Kari Bø, who probably is one of the most well-known researchers in pelvic health physiotherapy worldwide.She's been a Professor of Exercise Science at the Norwegian School of Sport Sciences since 1997 and has published more than 350 peer-reviewed papers on various topics like pelvic floor dysfunction, incontinence, pelvic girdle pain, and exercise during pregnancy.She has also held visiting and guest professorships at multiple universities in Australia, New Zealand, and Brazil. And after our recording she did send us a short bio where she mentioned that she's currently supervising 11 PhD students. So with everything she's involved in, we feel very honored that she took the time to join us for this conversation — where we focused on stress incontinence and the importance of pelvic floor training in physiotherapy. We also touched on broader topics related to pelvic floor care, including the competencies physiotherapists need in this field, adherence to pelvic floor training and much more.

My links:My Ko-fi: https://ko-fi.com/rhetoricrevolutionSend me a voice message!: https://podcasters.spotify.com/pod/show/liam-connerlyTikTok: ⁠https://www.tiktok.com/@mrconnerly?is_from_webapp=1&sender_device=pc⁠Email: ⁠rhetoricrevolution@gmail.com⁠Instagram: https://www.instagram.com/connerlyliam/Podcast | Latin in Layman's - A Rhetoric Revolution https://open.spotify.com/show/0EjiYFx1K4lwfykjf5jApM?si=b871da6367d74d92YouTube: https://www.youtube.com/@MrConnerly 

This podcast summarises the article 'Clinical and morphological features of corneal lymphoma in 26 horses (27 eyes)' by Jacob M. Morris, Mary E. Lassaline, Catherine M. Nunnery, Leandro B. C. Teixeira, Bianca C. Martins, Bret A. Moore, Kelly E. Knickelbein, Nicole M. Scherrer and Caryn E. Plummer. 

Take a sneak peek at this month's Fertility & Sterility! Articles discussed this month are:   01:03 (Not) My body, my choice? - Should physicians be facilitating gestational carrier arrangements in the absence of medical indication? 05:22 Morphological changes of endometriomas during pregnancy and after delivery detected using ultrasound 12:17 Hormone-free vs. follicle-stimulating hormone–primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial 24:37 Association of in vitro fertilization with severe maternal morbidity in low-risk patients without comorbidities 33:59 The association between primary ovarian insufficiency and increased multimorbidity in a large prospective cohort (Canadian Longitudinal Study on Aging) 41:28 Target trial emulation of preconception serum vitamin D status on fertility outcomes: a couples-based approach 52:59 Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship View Fertility and Sterility February 2025, Volume 123, Issue 2:https://www.fertstert.org/issue/S0015-0282(24)X0015-1 View Fertility and Sterility at https://www.fertstert.org/

In this week's episode, we discuss the relationship between infectious and chronic disease, and between germ theory and terrain theory of disease. Pathogens are real, and exogenous treatments like antibiotics can kill them. The health of the body is affected by diet, exercise, stress, and the microbiome, all of which can affect how susceptible a person is to getting sick from pathogens. We discuss gastric ulcers, Covid-19, pneumococcal disease, and comorbidities. Also: how do traditional vs modern diets affect the health, dental and otherwise, of people? Why do pre-industrial people not get cavities, or need orthodontia? Why do squirrels fed by humans develop similarly malformed skulls as babies fed modern diets? Finally: do we have a responsibility to point out the carnage that will result as the Trump administration goes after decades of entrenched interests?*****Our sponsors:Caraway: Non-toxic, beautiful, light ceramic cookware. Save $150 on a cookware set over buying individual pieces, and get 10% off your order at http://carawayhome.com/DarkHorse.Manukora: the most flavorful, delicious, and nutritious honey you'll ever have. Get $25 off your starter kit at http://www.Manukora.com/DarkHorseARMRA Colostrum is an ancient bioactive whole food that can strengthen your immune system. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.Mentioned in this episode:*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:RFK Jr on chronic and infectious disease: https://x.com/ChildrensHD/status/1885018213701800387RFK Jr on The Real Anthony Fauci: https://amzn.to/40INnxF (commission earned)Marshall et al 1985. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 142:436–9:https://onlinelibrary.wiley.com/doi/abs/10.5694/j.1326-5377.1985.tb113443.xEvolutionary Lens Livestream #88 – w discussion of Covid x comorbidities: https://www.youtube.com/watch?v=KSWu6DUFFt4&t=337sHanada et al 2021. Multiple comorbidities increase the risk of death from invasive pneumococcal disease under the age of 65 years. Journal of Infection and Chemotherapy, 27(9): 1311-1318: https://www.sciencedirect.com/science/article/abs/pii/S1341321X21001252Nutrition and Physical Degeneration, by Weston Price (1939): https://amzn.to/4jXciXl (commission earned)Chandler et al 2025. Morphological change in an isolated population of red squirrels (Sciurus vulgaris) in Britain. Royal Society Open Science, 12(1): 240555.https://royalsocietypublishing.org/doi/10.1098/rsos.240555Support the show

Blindsnakes have taken over the continent of Australia at rapid speed. We chat about their different body types and finish with some listener-submitted wild observations of unusual reptile behaviour. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Tiatragul S, Skeels A, Keogh JS. 2024. Morphological evolution and niche conservatism across a continental radiation of Australian blindsnakes. Evolution 78:1854–1868. DOI: 10.1093/evolut/qpae132. Other Links/Mentions: Robles-Gil A. 2024.After the Death of Cassius, the World's Largest Captive Crocodile, Scientists Are Trying to Solve the Mystery of His Age. Available at https://www.smithsonianmag.com/smart-news/after-the-death-of-cassius-the-worlds-largest-captive-crocodile-scientists-are-trying-to-solve-the-mystery-of-his-age-180985422/ (accessed December 5, 2024). Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com Intro visuals – Paul Snelling

Alternate Current Radio Presents: Boiler Room - Learn to protect yourself from predatory mass mediaOn this episode of Boiler Room the Social Rejects Club learns about hidden DICKS, not only in human anatomy but also in our media, government and all the other places globalist turds collude. As we come closer and closer to the 2024 election we're taking a critical look at what could LIE ahead for the United States and the global chess board. mRNA is back on the menu and a man eats too many magic mushrooms and chops his phallus off... all this and more on this episode of Boiler Room.Featured: Hesher, Spore, Infidel Pharaoh & RuckusSupport BOILER ROOM & ACRPatreonShop BOILER ROOM Merch Store

Our plant this week is Desert Cotton, which is also known as Kapok Bush. It turns out there is also a Kapok Tree, and that was totally not confusing at all when we were researching this episode.

Everyone knows about phonics/phonology as it's high on the national agenda for intervention currently, but it doesn't always work. A lot of SENCOs, especially in secondary, are feeling trapped by phonics and Ofsted feeling they don't have permission to try a new approach. Teachers are also frustrated that they are just being told to do the same thing over and over. Our new special guest, Louise Selby, joins Dale today to delve into the fascinating world of ‘Morphology'. Louise explains that the English language is made up of 3 systems: phonology, morphology and etymology. Did you know that 80% of our words are made up of morphemes? “Morphology is those prefixes, suffixes and roots. Those units of meaning in words which are such an integral part of our language.” Louise Selby, Dyslexia Specialist Louise explains the 3 systems and breaks down word examples and highlights that phonic rules don't always help: Shouted Phonic = sh + ou + t + i + d Morphological = shout + -ed Louise highlights that research shows that a meaning-based approach with morphology can be effective in intervention and teaching literacy. Join us as we explore the significance of morphology and its potential to transform literacy learning for all children. Listening to this episode will provide valuable insights into how morphology can unlock language skills, nurturing both comprehension and confidence.   About Louise Selby Louise worked as a specialist advisory teacher in Hertfordshire Local Authority for 11 years, where she gained extensive experience in training teaching assistants and SENCOs in meeting the needs of learners with specific learning difficulties. Before this, Louise worked as a class teacher and SENCO in the primary sector and also as a teacher of learners with English as an Additional Language. She now works freelance in advising, training and supporting schools as well as assessing for specific learning difficulties (dyslexia). Louise's interest is in enabling and equipping staff in schools at grass roots level to meet learners' needs.   Contact Louise https://twitter.com/louiseselby21 http://facebook.com/LouiseSelbyDyslexia https://louiseselbydyslexia.com/ louise@louiseselbydyslexia.com   Useful Links Louise's book - Morph Mastery   ·         B Squared Website – www.bsquared.co.uk  ·         Meeting with Dale to find out about B Squared - https://calendly.com/b-squared-team/overview-of-b-squared-sendcast  ·         Email Dale – dale@bsquared.co.uk  ·         Subscribe to the SENDcast - https://www.thesendcast.com/subscribe   The SENDcast is powered by B Squared We have been involved with Special Educational Needs for over 25 years, helping show the small steps of progress pupils with SEND make. B Squared has worked with thousands of schools, we understand the challenges professionals working in SEND face. We wanted a way to support these hardworking professionals - which is why we launched The SENDcast! Click the button below to find out more about how B Squared can help improve assessment for pupils with SEND in your school.

David Van Essen is an Alumni Endowed Professor of Neuroscience at Washington University School of Medicine in St. Louis. In this conversation, we talk about David's path to becoming a neuroscientist, the Human Connectome project, hierarhical processing in the cerebral cortex, and much more.BJKS Podcast is a podcast about neuroscience, psychology, and anything vaguely related, hosted by Benjamin James Kuper-Smith.Support the show: https://geni.us/bjks-patreonTimestamps0:00:00: David's childhood: ravens, rockets, and radios0:05:00: From physics to neuroscience (via chemistry)0:13:55: Quantitative and qualitative approaches to science0:19:17: Model species in neuroscience0:31:35: Hierarchical processing in the cortex0:46:54: The Human Connectome Project0:55:00: A book or paper more people should read0:58:01: Something David wishes he'd learnt sooner1:00:31: Advice for PhD students/postdocsPodcast linksWebsite: https://geni.us/bjks-podTwitter: https://geni.us/bjks-pod-twtDavid's linksWebsite: https://geni.us/VanEssen-webGoogle Scholar: https://geni.us/VanEssen-scholarBen's linksWebsite: https://geni.us/bjks-webGoogle Scholar: https://geni.us/bjks-scholarTwitter: https://geni.us/bjks-twtReferences & linksDavid's autobiographical sketch for the Society for Neuroscience (in Volume 9): https://www.sfn.org/about/history-of-neuroscience/autobiographical-chaptersFelleman & Van Essen (1991). Distributed hierarchical processing in the primate cerebral cortex. Cerebral Cortex.Glasser, Coalson, Robinson, Hacker, Harwell, Yacoub, ... & Van Essen (2016). A multi-modal parcellation of human cerebral cortex. Nature.Hubel & Wiesel (1962). Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. The Journal of physiology.Maunsell & Van Essen (1983). The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey. Journal of Neuroscience.Sheldrake (2021). Entangled life: How fungi make our worlds, change our minds & shape our futures.Van Essen & Kelly (1973). Morphological identification of simple, complex and hypercomplex cells in the visual cortex of the cat. In Intracellular Staining in Neurobiology (pp. 189-198).Van Essen & Maunsell (1980). Two‐dimensional maps of the cerebral cortex. Journal of Comparative Neurology.Van Essen (2012). Cortical cartography and Caret software. Neuroimage.Van Essen, Smith, Barch, Behrens, Yacoub, Ugurbil & WU-Minn HCP Consortium. (2013). The WU-Minn human connectome project: an overview. Neuroimage.Wooldridge (1963). The machinery of the brain.

NR2F1 Foundation's mission is to support those impacted by an NR2F1 mutation, aka Bosch-Boonstra-Schaaf optic atrophy syndrome through education, advocacy, and research. BBSOAS, also known as Bosch-Boonstra-Schaaf Optic Atrophy Syndrome, is a rare neurological disorder caused by a disruption in the NR2F1 gene. BBSOAS is characterized by a wide array of clinical features, but the most common are vision impairment caused by optic atrophy, developmental delay, and intellectual disability. There are currently a few hundred known cases of BBSOAS worldwide with diagnoses rapidly increasing every month. The phenotypic spectrum of Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is broad and variable, but the most well-established characteristics include developmental delay/intellectual disability and visual impairment (including optic nerve atrophy, optic nerve hypoplasia, and cortical visual impairment). Other common features include hypotonia, oromotor dysfunction, and mild and inconsistent dysmorphic facial features. Morphological changes in brain structures including thinning of the corpus callosum, and autism spectrum disorder are also considered common. Individuals are at an elevated risk of seizures, including infantile spasms. Genotype-phenotype correlations have been proposed, with individuals with mutations in the DBD typically showing a more severe phenotype, and individuals with whole-gene deletions and truncating mutations tending to have moderate to mild symptoms. Individuals with point mutations outside of the DBD most often manifest the mildest phenotype. BBSOAS is considered a static encephalopathy and has not been shown to be progressive/degenerative. There is no progression of the eye phenotype known, including no known progression of optic atrophy. Connect to learn more: Email: info@nr2f1.org Website: https://nr2f1.org/ FB: @NR2F1 Foundation IG: @nr2f1foundation Transcript: https://docs.google.com/document/d/1tiJV3qJmtUPPokZvdbIdlBEF7pgbXEyi/edit?usp=sharing&ouid=117716030289987185197&rtpof=true&sd=true As an Amazon Associate, I earn commissions from qualifying purchases. For more information about True North Disability Planning you can find us here: Web: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://truenorthdisabilityplanning.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Waypoints - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://waypoints.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: @TrueNorthDisabilityPlanning X (Twitter): @NeedsNavigator --- Send in a voice message: https://podcasters.spotify.com/pod/show/abcs-disability-planning/message Support this podcast: https://podcasters.spotify.com/pod/show/abcs-disability-planning/support

Morphological influence of functionalized and non-functionalized α,ω-dicarboxylates on calcite crystallization Stephen Mann, Jon M. Didymus, Nigel P. Sanderson, Brigid R. Heywood and Eliseo J. Aso Samper Abstract The influence of a range of α,ω-dicarboxylates on the morphology of calcite crystals grown from supersaturated bicarbonate solutions was studied by optical and scanning electron microscopy. At Ca/malonate ≈ 3, spindle-shaped crystals elongated along the c axis and with curved {110} prismatic faces were formed. This effect was reduced with increasing chain length. The unsaturated derivative, maleate, was intermediate in potency compared with the saturated malonate and succinate compounds. In contrast, the trans isomer, fumarate, had minimal morphological effect. Functionalization of the lower chain acids had a marked influence on crystal morphology. Crystals grown in the presence of aspartate (α-aminosuccinate) exhibited well defined {110} prismatic faces at Ca/additive = 17, whilst γ-carboxyglutamate had a pronounced effect at ratios as high as 85. The stabilization of the {110} faces of calcite by αω-dicarboxylate binding is described in terms of electrostatic, geometric and stereochemical recognition at the crystal/additive interface. Modelling Biomineralization: Studies on the Morphology of Synthetic Calcite J. M. Didymus, S. Mann, N. P. Sanderson, P. Oliver, B. R. Heywood & E. J. Aso-Samper Conference paper 372 Accesses 5 Citations Abstract Many organisms possess the remarkable ability to deposit single crystals of calcite (CaCCO3) with morphologies not normally observed in the inorganic world [1]. Whilst it is true that single geological crystals of calcite can exhibit an enormous range of different habits, all these forms have common interfacial angles and symmetry as described by the R̄3c space group. By contrast, the external forms of some biological single crystals of calcite have symmetries that are non-crystallographic. The coccolith segments deposited by the unicellular marine alga Emiliania huxleyi illustrate this phenomenon particularly well:- Current theories of biomineralization suggest that calcifying organisms have adopted strategies for controlling morphology based on the deployment of functional organic molecules. For example, proteins rich in aspartate and glutamate residues and also phosphoserine, are common for molluscs [3] whilst coccoliths of E. huxleyi are deposited along with sulphated and carboxylated polysaccharides [4]. Thus, carboxylate groups and, to a lesser extent, sulphates and phosphates play an important role in the biomineralization of calcite. --- Send in a voice message: https://podcasters.spotify.com/pod/show/on-air-ediciones/message

BUFFALO, NY- November 15, 2023 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.” Neurodegenerative disorders, such as Alzheimer's disease (AD), have the gradual onset of neurobiological changes preceding clinical diagnosis by decades. In their new study, researchers Qing Cao, Manasa Kumar, Allea Frazier, Jamal B. Williams, Shengkai Zhao, and Zhen Yan from the State University of New York at Buffalo's Jacobs School of Medicine and Biomedical Sciences aimed to elucidate how brain dysfunction proceeds in neurodegenerative disorders. “[...] we performed longitudinal characterization of behavioral, morphological, and transcriptomic changes in a tauopathy mouse model, P301S transgenic mice.” P301S mice exhibited cognitive deficits as early as 3 months old, and deficits in social preference and social cognition at 5–6 months. They had a significant decrease of arborization in basal dendrites of hippocampal pyramidal neurons from 3 months and apical dendrites of PFC pyramidal neurons at 9 months. Transcriptomic analysis of genome-wide changes revealed the enrichment of synaptic gene upregulation at 3 months of age, while most of these synaptic genes were downregulated in PFC and hippocampus of P301S mice at 9 months. These time-dependent changes in gene expression may lead to progressive alterations of neuronal structure and function, resulting in the manifestation of behavioral symptoms in tauopathies. “In conclusion, our longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model is to elucidate potential mechanisms that drive the progression of AD and related neurodegenerative disorders. Manipulation of key molecular players coupled with electrophysiological measurements of neuronal functions in future studies will help identify early intervention strategies for these diseases.” DOI - https://doi.org/10.18632/aging.205057 Corresponding author - Zhen Yan - zhenyan@buffalo.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205057 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Alzheimer's disease, tau, cognitive behaviors, transcriptomic, neuronal morphology About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.14.549060v1?rss=1 Authors: Stanczyk, P. J., Tatekoshi, Y., Shapiro, J. S., Nayudu, K., Chen, Y., Zeilber, Z., Schipma, M., De Jesus, A., Mahmoodzadeh, A., Akrami, A., Chang, H.-C., Ardehali, H. Abstract: BACKGROUND: Proper nuclear organization is critical for cardiomyocyte (CM) function, as global structural remodeling of nuclear morphology and chromatin structure underpins the development and progression of cardiovascular disease. Previous reports have implicated a role for DNA damage in cardiac hypertrophy, however, the mechanism for this process is not well delineated. AMPK family of proteins regulate metabolism and DNA damage response (DDR). Here, we examine whether a member of this family, SNF1-related kinase (SNRK), which plays a role in cardiac metabolism, is also involved in hypertrophic remodeling through changes in DDR and structural properties of the nucleus. METHODS: We subjected cardiac specific (cs)-Snrk-/- mice to trans-aortic banding (TAC) to assess the effect on cardiac function and DDR. In parallel, we modulated SNRK in vitro and assessed its effects on DDR and nuclear parameters. We also used phospho-proteomics to identify novel proteins that are phosphorylated by SNRK. Finally, co-immunoprecipitation (co-IP) was used to verify Destrin (DSTN) as the binding partner of SNRK that modulates its effects on the nucleus and DDR. RESULTS: cs-Snrk-/- mice display worse cardiac function and cardiac hypertrophy in response to TAC, and an increase in DDR marker pH2AX in their hearts. Additionally, in vitro Snrk knockdown results in increased DNA damage and chromatin compaction, along with alterations in nuclear flatness and 3D volume. Phospho-proteomic studies identified a novel SNRK target, DSTN, a member of F-actin depolymerizing factor (ADF) proteins that directly binds to and depolymerize F-actin. SNRK binds to DSTN, and DSTN downregulation reverses excess DNA damage and changes in nuclear parameters, in addition to cellular hypertrophy, with SNRK knockdown. We also demonstrate that SNRK knockdown promotes excessive actin depolymerization, measured by the increased ratio of globular (G-) actin to F-actin. Finally, Jasplakinolide, a pharmacological stabilizer of F-actin, rescues the increased DNA damage and aberrant nuclear morphology in SNRK downregulated cells. CONCLUSIONS: These results indicate that SNRK is a key player in cardiac hypertrophy and DNA damage through its interaction with DSTN. This interaction fine-tunes actin polymerization to reduce DDR and maintain proper CM nuclear shape and morphology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.03.547611v1?rss=1 Authors: Forsgren, E., Cloarec, O., Jonsson, P., Trygg, J. Abstract: Cell Painting is an established community-based, microscopy-assay platform that provides high-throughput, high-content data for biological readouts. In November 2022, the JUMP-Cell Painting Consortium released the largest annotated, publicly available dataset, comprising more than 2 billion cell images. This dataset is designed for predicting the activity and toxicity of 100k drug compounds, with the aim to make cell images as computable as genomes and transcriptomes. In this paper, we have developed a data analytics workflow that is both scalable and computationally efficient, while providing significant, biologically relevant insights for biologists estimating and comparing the effects of different drug treatments. The two main objectives proposed include: 1) a simple, yet sophisticated, scalable data analytics metric that utilizes negative controls for comparing morphological cell profiles. We call this metric the equivalence score (Eq. score). 2) A workflow to identify and amplify subtle morphological image profile changes caused by drug treatments, compared to the negative controls. In summary, we provide a data analytics workflow to assist biologists in interpreting high-dimensional image features, not necessarily limited to morphological ones. This enhances the efficiency of drug candidate screening, thereby streamlining the drug development process. By increasing our understanding of using complex image-based data, we can decrease the cost and time to develop new, life-saving treatments. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.30.547168v1?rss=1 Authors: Trotter, D., Pariz, A., Hutt, A., Lefebvre, J. Abstract: Non-invasive brain stimulation techniques are widely used for manipulating the behaviour of neuronal circuits and the excitability of the neurons therein. While the usage of these techniques is widely studied at the meso- and macroscopic scales, less is known about the specificity of such approaches at the level of individual cells. Here we use models based on the morphologies of real pyramidal and parvalbumin neurons from mouse primary visual cortex created by the Allen Institute for Brain Science to explore the variability and evoked response susceptibility of different morphologies to uniform electric fields. We devised a range of metrics quantifying various aspects of cellular morphology, ranging from whole cell attributes to net compartment length, branching, diameter to orientation. In supporting layer- and cell-type specific responses, none of these physical traits passed statistical significance tests. While electric fields can modulate somatic, dendritic and axonal compartments reliably and subtype-specific responses could be observed, the specificity of such stimuli was blurred by the variability in cellular morphology. These null results suggest that morphology alone may not account for the reported subtype specificity of brain stimulation paradigms, and question the extent to which such techniques may be used to probe and control neural circuitry. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.23.546309v1?rss=1 Authors: Xuan, W., Cheng, F., Han, X., Tipparaju, S., Ashraf, M. Abstract: Background: Extensive studies have been conducted in skeletal muscle and myocardium affected by Duchenne Muscular Dystrophy (DMD) disease but there is a significant gap of research in the role of vascular smooth muscle cells (VSMCs) in DMD. Here, we investigated the role of dystrophin deficiency in the maintenance of VSMCs contractile phenotype. Methods: 12-14 months old mdx mice and DMD induced pluripotent stem cells (iPSC) derived VSMCs were used as disease models. Morphological and immunohistochemistry analyses were performed to determine histological changes and the expression of contractile markers. Transmission Electron Microscopy (TEM) was used to assess ultrastructural changes in the VSMCs. Mito-tracker staining and TUNEL staining were performed to determine mitochondria fission-fusion and apoptosis respectively. mRNA Sequencing for normal iPSC derived VSMCs (WT-VSMCs) and DMD iPSC derived VSMCs (DMD-VSMCs) with or without oxidative stress was performed. KEGG signaling pathway enrichment, Go function enrichment and Gene set enrichment analysis (GESA) were conducted to explore the potential mechanism responsible for these changes. In addition, transcription factor enrichment analysis was performed to unravel mechanistic pathways of regulatory networks. Results: Spontaneous abnormal VSMCs proliferation, loss of vascular structure and degenerative changes occurred in VSMCs in aorta from 12-14 months old mdx mice. The DMD-VSMCs showed maturation defect, loss of mitochondrial hemostasis, and increased vulnerability to oxidative stress compared with WT-VSMCs. Transcriptome analysis revealed dysregulation of smooth muscle proliferation, differentiation, and vascular development in DMD-VSMCs. Transcriptional factor, target, and motif discovery analysis of the dysregulated gene set suggested potential contributions of transcriptional factors GADD45A, SOX9, TIA1, RBBP9 and FOXM to the phenotypes of DMD-VSMCs. Under oxidative stress, initiation of apoptotic process was significantly enhanced in DMD-VSMCs while their response to hypoxia and oxidative stress was downregulated. Conclusions: Dystrophin deficiency induced VSMCs phenotype switching and disrupted mitochondrial metabolism. The findings in this study underscore the importance of vascular dysfunction in DMD disease and therapeutic interventions to restore VSMC phenotype may ameliorate the propensity of disease progression. It is suggested that the transcriptome analysis may allow the discovery of potential signaling pathways involved in the dysregulation of transcription factors. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr Nathalie De Beukelaer KU-Leuven, University of GenevaPresentation title: Morphological muscle growth in infants and toddlers: a longitudinal study

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.22.537932v1?rss=1 Authors: Qi, L., Iskols, M., Shi, D., Reddy, P., Walker, C., Lezgiyeva, K., Voisin, T., Pawlak, M., Kuchroo, V. K., Chiu, I., Ginty, D. D., Sharma, N. Abstract: Mechanical and thermal stimuli acting on the skin are detected by morphologically and physiologically distinct sensory neurons of the dorsal root ganglia (DRG). Achieving a holistic view of how this diverse neuronal population relays sensory information from the skin to the central nervous system (CNS) has been challenging with existing tools. Here, we used transcriptomic datasets of the mouse DRG to guide development and curation of a genetic toolkit to interrogate transcriptionally defined DRG neuron subtypes. Morphological analysis revealed unique cutaneous axon arborization areas and branching patterns of each subtype. Physiological analysis showed that subtypes exhibit distinct thresholds and ranges of responses to mechanical and/or thermal stimuli. The somatosensory neuron toolbox thus enables comprehensive phenotyping of most principal sensory neuron subtypes. Moreover, our findings support a population coding scheme in which the activation thresholds of morphologically and physiologically distinct cutaneous DRG neuron subtypes tile multiple dimensions of stimulus space. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.11.536299v1?rss=1 Authors: Iyer, M., Kantarci, H., Ambiel, N., Novak, S. W., Andrade, L. R., Lam, M., Munch, A. E., Yu, X., Khakh, B. S., Manor, U. S., Zuchero, J. B. Abstract: Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length and thickness are regulated by neuronal activity and can precisely tune conduction velocity, but the mechanisms controlling sheath morphology are poorly understood. Local calcium signaling has been observed in nascent myelin sheaths and can be modulated by neuronal activity. However, the role of calcium signaling in sheath formation and remodeling is unknown. Here, we used genetic tools to attenuate oligodendrocyte calcium signaling during active myelination in the developing mouse CNS. Surprisingly, we found that genetic calcium attenuation did not grossly affect the number of myelinated axons or myelin thickness. Instead, calcium attenuation caused striking myelination defects resulting in shorter, dysmorphic sheaths. Mechanistically, calcium attenuation reduced actin filaments in oligodendrocytes, and an intact actin cytoskeleton was necessary and sufficient to achieve accurate myelin morphology. Together, our work reveals a novel cellular mechanism required for accurate CNS myelin formation and provides mechanistic insight into how oligodendrocytes may respond to neuronal activity to sculpt myelin sheaths throughout the nervous system. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The gang discusses two papers that use morphometric studies to investigate patterns of ecomorphy in the fossil record. Specifically, they look at two papers that investigate how morphology in sloths and pterosaurs changes over time, and how well these changes map onto changes in body size and ecological shifts. Meanwhile, Amanda could be dean, Curt has opinions on figures, and James provides butchery advice.   Up-Goer Five (Curt Edition): The friends talk about two papers that look at how things look and how that changes over time, and looks to see if these things are changing because of what they do. The first paper looks at animals with hair and long arms that move very slow. There are not a lot of these animals today, but in the past there was a lot of these animals and they did a lot of other things that we do not see them do today. These animals were also looking different as well. But it seems that the things that look different are closer to each other by being close sisters to each other. They also do find that these animals are also doing different things when they look different. The second paper looks at angry animals who can fly but are not the animals that can fly today. These animals start small and get big over time. They actually get big a few times. This paper looks at the parts of these animals and shows the many different ways that parts can change to make these animals big or small. It also shows that, when these things get really big is when the group seems to be doing really bad.   References: Yu, Yilun, Chi Zhang, and Xing Xu. "Complex macroevolution of pterosaurs." Current Biology 33.4 (2023): 770-779. Casali, Daniel M., et al.  "Morphological disparity and evolutionary rates of cranial and  postcranial characters in sloths (Mammalia, Pilosa, Folivora)." Palaeontology 66.1 (2023): e12639.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.30.534941v1?rss=1 Authors: Ingram, S., DeCorte, A., Gentry, A. E., Philpott, M. K., Moldenhauer, T., Stadler, S., Steinberg, C., Millman, J., Ehrhardt, C. J. Abstract: Analysis of DNA mixtures from sexual assault evidence is an ongoing challenge for DNA casework laboratories. There is a significant need for new techniques that can provide information as to the source of DNA, particularly for sexual assault samples that do not involve semen. The goal of this study was to develop a new biological signature system that provides additional probative value to samples comprised of mixtures of epidermal and vaginal cells, as may be observed in cases involving digital penetration. Signatures were based on morphological and autofluorescence properties of individual cells collected through Imaging Flow Cytometry (IFC). Comparisons to reference cell populations from vaginal tissue and epidermal cells collected from hands showed strong multivariate differences across greater than 80 cellular measurements. These differences were used to build a predictive framework for classifying unknown cell populations as originating from epithelial cells associated with digital penetration or epidermal tissue. As part of the classification scheme, posterior probabilities of specific tissue group membership were calculated for each cell, along with multivariate similarity to that tissue type. We tested this approach on cell populations from reference tissue as well as mock casework samples involving digital penetration. Many more cells classifying as non-epidermal tissue were detected in digital penetration samples than control hand swabbings. Minimum interpretation thresholds were developed to minimize false positives; these thresholds were also effective when screening licked hands, indicating the potential utility of this method for a variety of biological mixture types and depositional events relevant to forensic casework. Results showed that samples collected subsequent to digital penetration possessed markedly higher numbers of cells classifying as vaginal tissue as well as higher posterior probabilities for vaginal tissue ( greater than or equal to 0.90) compared to cell populations collected from hands without prior contact with vaginal tissue. Additionally, digital penetration cell populations may be resolved from saliva cell populations and other non-target tissue types. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Old clip: "The Relationship Between Designing New Materials and The Morphological Structure" by Marwa ElDiwiny

Genetic engineering is a controversial topic. From vaccines to fetal cells to transhumanism, the debate rages. Yet, there are certain aspects to genetic engineering that are demonstrably good. How are we supposed to make heads or tails of this new technology, especially since it is impacting every aspect of our lives? I thought that a simple explanation (at least, as simple as I could make it!) of the things I did while earning my PhD could help increase our understanding. I, as a conservative Christian, made the 'frankenfish'. I stole the genes for the bright green and red fluorescent proteins in corals, engineered them into bacteria, then into fish. There is nothing inherently difficult in what I did, but there were a LOT of steps. Perhaps, after this explanation, we can have a more civil discussion on the pros and cons. Links and notes: Gibbs PDL, Carter RW, and Schmale MC (2008) Nucleic acid encoding fluorescent proteins from aquatic species. US Patent #7,413,874. Gibbs PDL, Carter RW, and Schmale MC (2007) Fluorescent Proteins from Aquatic Species. US Patent #7,291,711. Carter RW, Schmale MS, and Gibbs PDL (2004) Cloning of anthozoan fluorescent protein genes. Comparative Biochemistry and Physiology, Part C 138:259–270. Carter RW (2003) Cnidarian Fluorescent Proteins. PhD Dissertation. University of Miami. Manica A, Carter RW (2000) Morphological and fluorescence analysis of the Montastraea annularis species complex in Florida. Marine Biology 137:899–906. Monkeying around with human embryos? Harnessing God's design to help prevent sickness, but will the new vaccine technology alter our DNA? Unnatural selection: CRISPR on Netflix Gene editing babies? A dangerous, pointless experiment Human/animal hybrids? Human Cloning? Mammoth clones coming to a zoo near you

Genetic engineering is a controversial topic. From vaccines to fetal cells to transhumanism, the debate rages. Yet, there are certain aspects to genetic engineering that are demonstrably good. How are we supposed to make heads or tails of this new technology, especially since it is impacting every aspect of our lives? I thought that a simple explanation (at least, as simple as I could make it!) of the things I did while earning my PhD could help increase our understanding. I, as a conservative Christian, made the 'frankenfish'. I stole the genes for the bright green and red fluorescent proteins in corals, engineered them into bacteria, then into fish. There is nothing inherently difficult in what I did, but there were a LOT of steps. Perhaps, after this explanation, we can have a more civil discussion on the pros and cons. Links and notes: Gibbs PDL, Carter RW, and Schmale MC (2008) Nucleic acid encoding fluorescent proteins from aquatic species. US Patent #7,413,874. Gibbs PDL, Carter RW, and Schmale MC (2007) Fluorescent Proteins from Aquatic Species. US Patent #7,291,711. Carter RW, Schmale MS, and Gibbs PDL (2004) Cloning of anthozoan fluorescent protein genes. Comparative Biochemistry and Physiology, Part C 138:259–270. Carter RW (2003) Cnidarian Fluorescent Proteins. PhD Dissertation. University of Miami. Manica A, Carter RW (2000) Morphological and fluorescence analysis of the Montastraea annularis species complex in Florida. Marine Biology 137:899–906. Monkeying around with human embryos? Harnessing God's design to help prevent sickness, but will the new vaccine technology alter our DNA? Unnatural selection: CRISPR on Netflix Gene editing babies? A dangerous, pointless experiment Human/animal hybrids? Human Cloning? Mammoth clones coming to a zoo near you

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.17.533103v1?rss=1 Authors: Gallardo, G., Eichner, C., Sherwood, C. C., Hopkins, W. D., Anwander, A., Friederici, A. D. Abstract: Human language is supported by a cortical network involving Broca's area which comprises Brodmann Areas 44 and 45 (BA44, BA45). While cytoarchitectonic homolog areas have been identified in nonhuman primates, it remains unknown how these regions evolved to support human language. Here, we use histological data and advanced cortical registration methods to precisely compare the morphology of BA44 and 45 between humans and chimpanzees. We found a general expansion of Broca's areas in humans, with the left BA44 enlarging the most, growing anteriorly into a region known to process syntax. Together with recent functional studies, our findings show that BA44 evolved from a purely action-related region to a more expanded region in humans, with a posterior portion supporting action and an anterior portion supporting syntactic processes. Furthermore, our findings provide a solution for the long- standing debate concerning the structural and functional evolution of Broca's area and its role in action and language. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.20.528549v1?rss=1 Authors: Harmata, G. I. S., Barsotti, E. J., Casten, L. G., Fiedorowicz, J. G., Williams, A. J., Shaffer, J. J., Richards, J. G., Sathyaputri, L., Schmitz, S. L., Christensen, G. E., Long, J. D., Gaine, M. E., Xu, J., Michaelson, J. J., Wemmie, J. A., Magnotta, V. A. Abstract: Background: The neural underpinnings of bipolar disorder (BD) remain poorly understood. The cerebellum is ideally positioned to modulate emotional regulation circuitry yet has been understudied in BD. Previous studies have suggested differences in cerebellar activity and metabolism in BD, however findings on cerebellar structural differences remain contradictory. Methods: We collected 3T anatomical MRI scans from participants with (N = 131) and without (N = 81) BD type I. Differences in cerebellar volumes were assessed along with factors that influence the results. Results: The cerebellar cortex was smaller bilaterally in participants with BD. Polygenic propensity score (bipolar N = 103, control N = 64) did not predict any cerebellar volumes, suggesting that non-genetic factors may have greater influence on the cerebellar volume difference we observed in BD. Cerebellar white matter volumes increased with more adverse childhood events, but we did not observe any associations with parental psychiatric illness. We also evaluated time from onset and symptom burden and found no associations with cerebellar volumes, suggesting neurodevelopment may differ prior to onset. Finally, we found taking sedatives was associated with larger cerebellar white matter and non-significantly larger cortical volume. Limitations: This study was cross-sectional, limiting interpretation of possible mechanisms. Most of our participants were White, which could limit the generalizability. Additionally, we did not account for potential polypharmacy interactions. Conclusions: These findings suggest that external influences, such as medications, may influence cerebellum structure in BD and may mask underlying differences. Accounting for medication may be critical for consistent findings in future studies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Chris interviews Rupeshika Gunawardana from the University of Kelaniya, Sri Lanka. Contacts: haswell247@gmail.com, LostInCitations@gmail.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.25.525394v1?rss=1 Authors: Tillotson, R., Yan, K., Ruston, J., de Young, T., Cordova, A., Turcotte-Cardin, V., Yee, Y., Taylor, C., Visuvanathan, S., Babbs, C., Ivakine, E. A., Sled, J. G., Nieman, B. J., Picketts, D. J., Justice, M. J. Abstract: ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological function remains elusive. Hypomorphic mutations in the X-linked ATRX gene cause a rare form of intellectual disability combined with alpha-thalassemia called ATR-X syndrome in hemizygous males. Patients also have facial dysmorphism, microcephaly, musculoskeletal defects and genital abnormalities. Since complete deletion of ATRX in mice results in early embryonic lethality, the field has largely relied on conditional knockout models to assess the role of ATRX in multiple tissues. Given that null alleles are not found in patients, a more patient-relevant model was needed. Here, we have produced and characterised the first patient mutation knock-in model of ATR-X syndrome, carrying the most common patient mutation, R246C. This is one of a cluster of missense mutations located in the chromatin interaction domain that disrupts its function. The knock-in mice recapitulate several aspects of the patient disorder, including craniofacial defects, microcephaly and impaired neurological function. They provide a powerful model for understanding the molecular mechanisms underlying ATR-X syndrome and for testing potential therapeutic strategies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Okay, so don't let the title put you off. Morphological Analysis is neither as close to being as scary as it sounds nor as complicated to execute. What it can do is help you make interesting new connections between seemingly unrelated things. Those kinds of connections can result in stories no one saw coming. (I'm looking at you, Pride and Prejudice and Zombies.) Many moons ago, when I worked at Ford Motor Company, and later at what is now Warner Bros. Discovery, I ran innovation workshops and Morphological Analysis was one tool I used with my students. Of all the innovation tools I used, Morphological Analysis stuck with me because it's great for writers. Back then, it was all about problem statements, functions, and morphologies, but what stood out to me were dimensions. Stories have dimensions. They have genre, character, style, structure, content and so on. I've used the tool with clients as part of my Story Development package, but I thought it'd be useful to share it with you. Here's the blog post that goes with this episode and it has diagrams so you can better visualise how it all fits together: https://www.thebookcoach.co/post/how-to-create-story-ideas-using-morphological-analysis

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.27.522042v1?rss=1 Authors: Labitigan, R. L. D., Sanborn, A. L., Hao, C. V., Chan, C. K., Belliveau, N. M., Brown, E. M., Mehrotra, M., Theriot, J. A. Abstract: The contributions of individual genes to cell-scale morphology and cytoskeletal organization are challenging to define due to the wide intercellular variation of these complex phenotypes. We leveraged the controlled nature of image-based pooled screening to assess the impact of CRISPRi knockdown of 366 genes on cell and nuclear morphology in human U2OS osteosarcoma cells. Screen scale-up was facilitated by a new, efficient barcode readout method that successfully genotyped 85% of cells. Phenotype analysis using a deep learning algorithm, the {beta}-variational autoencoder, produced a feature embedding space distinct from one derived from conventional morphological profiling, but detected similar gene hits while requiring minimal design decisions. We found 45 gene hits and visualized their effect by rationally constrained sampling of cells along the direction of phenotypic shift. By relating these phenotypic shifts to each other, we construct a quantitative and interpretable space of morphological variation in human cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.22.521541v1?rss=1 Authors: Weis, M. A., Papadopoulos, S., Hansel, L., Lueddecke, T., Celii, B., Fahey, P. G., Bae, J. A., Bodor, A. L., Brittain, D., Buchanan, J., Bumbarger, D. J., Castro, M. A., Cobos, E., Collman, F., da Costa, N. M., Dorkenwald, S., Elabbady, L., Froudarakis, E., Halageri, A., Jia, Z., Jordan, C., Kapner, D., Kemnitz, N., Kinn, S., Lee, K., Li, K., Lu, R., Macrina, T., Mahalingam, G., Mitchell, E., Mondal, S. S., Mu, S., Nehoran, B., Patel, S., Pitkow, X., Popovych, S., Reid, R. C., Schneider-Mizell, C. M., Seung, H. S., Silversmith, W., Sinz, F. H., Takeno, M., Torres, R., Turner, N. L., Wong, W., Abstract: Neurons in the neocortex exhibit astonishing morphological diversity which is critical for properly wiring neural circuits and giving neurons their functional properties. The extent to which the morphological diversity of excitatory neurons forms a continuum or is built from distinct clusters of cell types remains an open question. Here we took a data-driven approach using graph-based machine learning methods to obtain a low-dimensional morphological "bar code" describing more than 30,000 excitatory neurons in mouse visual areas V1, AL and RL that were reconstructed from a millimeter scale serial-section electron microscopy volume. We found a set of principles that captured the morphological diversity of the dendrites of excitatory neurons. First, their morphologies varied with respect to three major axes: soma depth, total apical and basal skeletal length. Second, neurons in layer 2/3 showed a strong trend of a decreasing width of their dendritic arbor and a smaller tuft with increasing cortical depth. Third, in layer 4, atufted neurons were primarily located in the primary visual cortex, while tufted neurons were more abundant in higher visual areas. Fourth, we discovered layer 4 neurons in V1 on the border to layer 5 which showed a tendency towards avoiding deeper layers with their dendrites. In summary, excitatory neurons exhibited a substantial degree of dendritic morphological variation, both within and across cortical layers, but this variation mostly formed a continuum, with only a few notable exceptions in deeper layers. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.13.519447v1?rss=1 Authors: Bergaglio, T., Bhattacharya, S., Thompson, D., Nirmalraj, P. N. Abstract: Understanding the dose-dependent effect of over-the-counter drugs on red blood cells (RBCs) is crucial for hematology and digital pathology. Yet, it is challenging to continuously record the real-time, drug-induced nanoscopic shape changes of RBCs in a label-free manner. Here, we demonstrate digital holotomography (DHTM) enabled real-time, label-free concentration-dependent and time-dependent monitoring of ibuprofen on RBCs from a healthy donor. The RBCs are segmented based on 3D and 4D refractive index tomograms and their morphological and chemical parameters are retrieved with their shapes classified using machine learning. We directly observed the formation and motion of spicules on the RBC membranes when aqueous solutions of ibuprofen were drop cast on wet blood, creating rough-membraned echinocyte forms. At low concentrations of 0.25-0.50 mM, the ibuprofen-induced morphological change was transient but at high concentrations (1.5-3 mM) the spiculated RBC remained over a period of up to 1.5 hours. Molecular simulations confirmed that aggregates of ibuprofen molecules at high concentrations significantly disrupted the RBC membrane structural integrity and lipid order, but produced negligible effect at low ibuprofen concentrations. Control experiments on the effect of urea, hydrogen peroxide and aqueous solutions on RBCs showed zero spicule formation. Our work elucidates the dose-dependent chemical effects on RBCs using label-free microscopes that can be deployed for the rapid detection of overdosage of over-the-counter and prescribed drugs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.29.514375v1?rss=1 Authors: Han, X., Guo, S., Ji, N., Li, T., Liu, J., Ye, X., Wang, Y., Yun, Z., Xiong, F., Rong, J., Liu, D., Ma, H., Wang, Y., Huang, Y., Zhang, P., Wu, W., Ding, L., Hawrylycz, M., Lein, E., Ascoli, G. A., Xie, W., Liu, L., Zhang, L., Peng, H. Abstract: Quantification of individual cells' morphology and their distribution at the whole brain scale is essential to understand the structure and diversity of cell types. Despite recent technological advances, especially single cell labeling and whole brain imaging, for many prevailing animal models, it is exceedingly challenging to reuse similar technologies to study human brains. Here we propose Adaptive Cell Tomography (ACTomography), a low-cost, high-throughput, high-efficacy tomography approach, based on adaptive targeting of individual cells suitable for human-brain scale modeling of single neurons to characterize their 3-D structures, statistical distributions, and extensible for other cellular features. Specifically, we established a platform to inject dyes into cortical neurons in surgical tissues of 18 patients with brain tumors or other conditions and 1 donated fresh postmortem brain. We collected 3-D images of 1746 cortical neurons, of which 852 neurons were subsequentially reconstructed to quantify their local dendritic morphology, and mapped to standard atlases both computationally and semantically. In our data, human neurons are more diverse across brain regions than by subject age or gender. The strong stereotypy within cohorts of brain regions allows generating a statistical tensor-field of neuron morphology to characterize 3-D anatomical modularity of a human brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Aging of galaxies along the morphological sequence, marked by bulge growth and disk quenching by Louis Quilley et al. on Tuesday 18 October We revisit the color bimodality of galaxies using the extensive EFIGI morphological classification of nearby galaxies. The galaxy SDSS images in the g, r and i bands are decomposed as bulge+disk using SourceXtractor++. The spectral energy distributions made of our gri photometry complemented with GALEX NUV are fitted with ZPEG in order to estimate the stellar masses and specific star formations rates (sSFR) of whole galaxies as well as their bulge and disk components. The absolute NUV-r color versus stellar mass diagram shows a continuous relationship between the present sSFR of galaxies and their stellar mass, that spans all morphological types of the Hubble sequence. Irregular galaxies to Sab spirals make up the Blue Cloud, the Green Plain (formerly Valley) is made up of early-type spirals (S0a-Sa) while the Red Sequence contains all lenticular and elliptical galaxies, with systematically higher masses for the ellipticals. Galaxies across the Green Plain undergo a marked growth by a factor 2 to 3 in their bulge-to-total mass ratio and a systematic profile change from pseudo to classical bulges, as well as a significant reddening interpreted as star formation fading in their disks. Therefore, the Green Plain is a transition region, and we exclude a predominantly quick transit due to rapid quenching. We suggest that tracers of increased star formation (bright HII regions, spiral arms, flocculence) determine the limited scatter of the Main Sequence of star-forming galaxies. The high frequency of bars for all spirals as well as the stronger spiral arms and flocculence in the knee of the Green Plain suggest that internal dynamics, likely triggered by flybys or mergers, may be the key to the bulge growth of massive disk galaxies, marker of the aging of galaxies from star forming to quiescence. The Hubble sequence can then be considered as an inverse sequence of galaxy physical evolution. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2206.04707v2

Join Sally as she talks with Suzanne Koucheravy about dancers with scoliosis. Learn tools to best handle working with these beautiful bodies in your dance studio. Dancers with Scoliosis NotesSuzanne Koucheravyskoucheravy56@gmail.comWebsite: www.benemotus.comInstagram: benemotus_scolio_pilatesskoucheravy@bodydynamicsinc.comScolio-Pilates website: www.osteopilates.comFounder Karena ThekIADMS: International Association of Dance Medicine and Sciencewww.iadms.org 2022 Conference October 27-31 Limerick Ireland Scoliosis Research Society: www.srs.org International Society on Scoliosis Orthopaedic and Rehabilitation Treatment(SOSORT): www.sorsort.orgSchroth Method:www.schrothmethod.com Stephanie Sorota: “Dancing with Scoliosis”https://www.washingtonballet.org/a-dancers-diary-stephanie-sorota-and-dancing-with-scoliosis/ ReferencesLongworth B, Fary R, Hopper D. Prevalence and predictors of adolescent idiopathic scoliosis in adolescent ballet dancers. Arch Phys Med Rehabil. 2014 Sept;95(9): 1725-30. Stienberg N, Herskovitz I, Peleg S, dar G, Masharawi Y, Zeev A, Siev-Ner I. Morphological characteristics of the young scoliotic dancer. Phys Ther in Sport 2013 Nov;14(4). www.sciencedirect.com/science/article/abs/pii/S1466853.Steinburg N, Tenenbaum S, Zeev A, Pantanowitz M, Waddington G, Dar G, Siev-Ner I, Generalized joint hypermobility, scoliosis, patella femoral pain and physical abilities in your dancers. BMC Musculoskeletal Disorders (2021) 22:161. Https://doi.org/10.1186/s12891-021-04023-z.Stienberg N, Siev-Ner I, Peleg S, dar G, Masharawi Y, Zeev A, Hershkovitz I. Injuries in female dancers aged 8 to 16 years. J Athl train 2013 Jan-Feb;48(1):118-23.Czaprowski D, Kotwicki T, Pawlowska P, Stolinski L.  Joint Hypermobility in Children with Idiopathic Scoliosis: SOSORT award 2011 winner. Scoliosis. 2011;6: 22. PubMedPMC3204294.. Air M, Grierson M, Davenport K, Krabak B, Dissecting the doctor-dancer relationship: health care decision making among American collegiate dancers  PM R 2014 Mar;6(3): 241-9. Doe:10.1016/j.pmrj.2013.09.001 Pub 2013 Sept 10.Wong A, Chan C, Hiller,C, Yung P, Lau K, Samartzis, Surgenor,B  Is scoliosis associated with dance injury in young recreational dancers?  A large-scale cross -sectional epidemiological study J Dance Med Sci 2022 Mar 15:26 (1);41-49.doi: 10.12678/1089-313X.031522f. Epub 2021 Dec 5.Monticone M, Ambrosini E, Cazzaniga D, Rocca B, Ferrante S. Active self-correction and task oriented exercises reduce spinal deformity and improve quality of life in subjects with mild adolescent idiopathic scoliosis. Results of a randomized controlled trail. Eur Spine J (2014) 23:1204-1214 doi: 10.007/s00586-014-3241-y.Have an idea or suggestion for a future podcast? Call our voicemail:703-981-0718How to rate and review this podcast.Step by Step Instructions on Leaving a Review on AppleStep OneOpen the Podcasts app on your iPhone, iPad, or Mac.Step TwoNavigate to the page of the podcast you want to leave a review for. You can find it by searching for The Dance Studio Podcast or selecting it from your library. Just note that you'll have to go to the series page which shows all the episodes, not just the page for a single episode.Step ThreeScroll down to find the subhead titled “Ratings & Reviews.”Step FourUnder the highlighted reviews, sOriginal music and audio production provided by Jarrett Nicolay at Mixtape Studios. www.mynewmixtape.com

ABOUT TODAY's EPISODE Following up from last week's episode on the hair cuticle, today's episode focuses on all we can do to preserve the cuticle. If you want to see inches, and you have not been paying attention to the hair cuticle, then this episode is for you. I discuss why the cuticle is important, what is causes damage and steps we can take to preserve it, as long as possible. Cuticle damage will lead to exposure of the hair cortex, leading to split ends and we do not want that! Enjoy and make sure you apply the knowledge. SUPPORT! Thank you SO much for your constant support. It means the world to me. If you are wondering how you can support, please see below Share share share to the ends of the world: You can share this podcast to as many people as you know and love. You does not love a fun podcast about hair and skin? See links for that here https://linktr.ee/ChiomaAgha Support financially: https://anchor.fm/chioma-agha Download: Do you know that you can download any episode? Take me (well my voice, LOL) anywhere you are. Just click on download, and voila! Listen: Errmmm listen listen and listen again. You can listen one zillion uncountable billion times. LOL. Listen to the Ads ooooooo. T for Tenks REFERENCES 1. Takahashi, Mamada, Kiwaza et al. "Age dependent damage for hair cuticle: contribution of S100A3 protein and its citrullination". Journal of cosmetic dermatology. 2015 2. BIRBECK, M S, and E H MERCER. “The electron microscopy of the human hair follicle. II. The hair cuticle.” The Journal of biophysical and biochemical cytology vol. 3,2 (1957): 215-22. doi:10.1083/jcb.3.2.215 3. M. Richena, C.A. Rezende. "Morphological degradation of human hair cuticle due to simulated sunlight irradiation and washing". Journal of Photochemistry and Photobiology B: Biology, Volume 161, 2016, Pages 430-440, ISSN 1011-1344. 4. Robbins, C.R. (2012) Chemical and Physical Behavior of Human Hair. 5th Edition. Disclaimer The information provided on this podcast, including but not limited to, text, graphics, are for informational purposes only and does not serve as a diagnosis, treatment or substitute for medical advice. Always seek the advice of a qualified health care professional for any medical condition you may be experiencing. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/chioma-agha/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.05.510951v1?rss=1 Authors: Dzyubenko, E., Willig, K. I., Yin, D., Sardari, M., Tokmak, E., Labus, P., Schmermund, B., Hermann, D. M. Abstract: Stroke remains one of leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic recovery mechanisms in the brain. Here, we explored the involvement of perineuronal nets (PNNs), the facet-like layers of extracellular matrix surrounding fast-spiking interneurons, in brain remodeling and neurological recovery after focal cerebral ischemia in mice with and without induced stroke tolerance. Due to insufficient resolution of conventional microscopy methods, the contribution of ultrastructural changes in PNNs to post stroke brain plasticity remained unknown. Using superresolution stimulated emission depletion (STED) and structured illumination (SR-SIM) microscopy, we revealed that PNN facets become larger and less dense in the post-acute stroke phase. Morphological alterations in PNNs are likely mediated by activated microglia cells, which preferentially enwrap the PNN-coated neurons. The loosening of PNNs is transient and associates with the increased number of GABAergic axonal terminals on inhibitory interneurons in the motor cortical layer 5. The coherent remodeling of PNNs and inhibitory synapses precedes the recovery of motor coordination during the late post-acute stroke phase. In the chronic stroke phase, the initial morphology of PNNs is restored, and the number of GABAergic axonal terminals on motor cortical interneurons is reduced. Our data suggests a novel mechanism of motor cortical plasticity after stroke, and we propose that prolonging PNN loosening during the post-acute period can extend the opening neuroplasticity window into the chronic stroke phase. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.27.509759v1?rss=1 Authors: Watanabe, A., Guo, C., Sjostrom, P. J. Abstract: Though once thought of as passive support cells for neurons, it is now clear that astrocytes signal via calcium (Ca2+) to trigger gliotransmission that impacts surrounding neurons and synapses. We therefore investigated how astrocytes in layer-5 (L5) mouse visual cortex mature electrophysiologically and morphologically over postnatal days (P) 3 - 30 and how these relate to changes in spontaneous Ca2+ events. Across this age range, resting membrane potential increased, and input resistance decreased. Astrocytes also revealed different membrane responses to voltage steps: notably, membrane responses became more passive with age. Two-photon (2p) imaging of dye-loaded patched cells and confocal imaging revealed that gap-junction coupling increased starting around P7. Morphological reconstructions revealed increased branch density but also shorter branches after P20, suggesting that astrocyte branches may get pruned as dense tiling is established. Finally, we visualized spontaneous Ca2+ transients with 2p microscopy and found that Ca2+ events decorrelated, became more frequent as well as briefer with age. As astrocytes mature, spontaneous Ca2+ activity thus changes from relatively cell-wide, synchronous waves to local transients. Several astrocyte properties were stably mature from ~P15 onwards, although morphology continued to develop further. Our findings provide a descriptive foundation of astrocyte maturation, useful for the study of astrocytic impact on visual cortex critical period plasticity. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Machine learning technique for morphological classification of galaxies from the SDSS III Image-based inference of detailed features by V. Khramtsov et al. on Monday 26 September This paper follows series of our works on the applicability of various machine learning methods to the morphological galaxy classification (Vavilova et al., 2021, 2022). We exploited the sample of 315776 SDSS DR9 galaxies with absolute stellar magnitudes of -24m

Welcome to the Juras-Sick Park-Cast podcast, the Jurassic Park podcast about Michael Crichton's 1990 novel Jurassic Park, and also not about that, too.  Find the episode webpage at: Episode 26 - Control  In this episode (stream it here), my terrific guest Dr. Jordan Mallon returns to chat with me about: Tyrannosaurus imperator, T-regina, and T-rex, amorphous reptile bones, lumping and splitting, species diversity, extinctions, Triceratops trivia, big dinosaurs in Late Cretaceous North America, the bias in the fossil record towards large dinosaurs, naming dinosaurs like Spiclypeus, dinosaur names based on the Jurassic Park film, dinosaurs named in honour of Michael Crichton, dino-mania, styracosterna v. ankylopollexa, comparative anatomy, hadrosaurs v. saurolphines, synonymizing dinosaur names, Gryposaurus, Edmontosaurus v . Ugrunaaluk, phylogenetic mapping, why DNA doesn't preserve (hint, it's water!), and more! Plus dinosaur news about: Insufficient Evidence for Multiple Species of Tyrannosaurus in the Latest Cretaceous of North America: A Comment on “The Tyrant Lizard King, Queen and Emperor: Multiple Lines of Morphological and Stratigraphic Evidence Support Subtle Evolution and Probable Speciation Within the North American Genus Tyrannosaurus” A specimen-level phylogenetic analysis and taxonomicrevision of Diplodocidae (Dinosauria, Sauropoda) Featuring the music of Snale https://snalerock.bandcamp.com/releases  Intro: Supergroovy.  Outro: T-Shirts. The Text: This week's text is Control, spanning from pages 126 - 133.  Synopsis: As Jurassic Park's employees conclude their demonstration of all their systems of control, Grant and Malcolm find themselves uneasy with the park's approach to controlling living, breathing animals in an artificial setting, which is aiming to recreate a natural park setting. Discussions surround: The Dinosaurs, Version 4.4, Control is a Hoax, the Timeline, and the God Complex. Corrections: Side effects:  May cause animals like the Gila monster and rattlesnake to share their hemotoxins. Find it on iTunes, on Spotify (click here!) or on Podbean (click here). Thank you! The Jura-Sick Park-cast is a part of the Spring Chickens banner of amateur intellectual properties including the Spring Chickens funny pages, Tomb of the Undead graphic novel, the Second Lapse graphic novelettes, The Infantry, and the worst of it all, the King St. Capers. You can find links to all that baggage in the show notes, or by visiting the schickens.blogpost.com or finding us on Facebook, at Facebook.com/SpringChickenCapers or me, I'm on twitter at @RogersRyan22 or email me at ryansrogers-at-gmail.com.  Thank you, dearly, for tuning in to the Juras-Sick Park-Cast, the Jurassic Park podcast where we talk about the novel Jurassic Park, and also not that, too. Until next time!  #JurassicPark #MichaelCrichton

Timestamps: 1:09 - The relationship between training volume and strength adaptations vs training intensity and strength adaptations 6:48 - How Brian prefers to periodize training for long term strength development 15:01 - Beginner vs intermediate vs advanced lifter differences in programming & periodization & the importance of occasional submaximal phases of training 21:47 - Morphological adaptations driven by higher intensities 24:32 - Neurological adaptations driven by higher intensities 29:24 - How to individualize training priorities (volume vs intensity) based off of athlete needs and athlete psychology 39:57 - Body fat percentages & powerlifting performance - how lean should you be to optimize performance and competitiveness 52:02 - How to optimize gaining muscle & moving up a weight class as a powerlifter Brain's Website - https://myojournal.com/ Brian's Instagram - https://www.instagram.com/bdminor/ 3DMJ - https://3dmusclejourney.com/ Coaching and Programming - https://adampeeler-fitness.com/ My Instagram - https://www.instagram.com/adamdpeeler/ Built Bar (code PEELER for 10% off) - https://builtbar.com/

Lizards can live in some tough environments, but does any lizard top the chubby Phymaturus living on the side of an active volcano? This episode we explore how they are coping with repeated ashfall events, as well as highlighting a newly described Phymaturus species. Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Boretto JM, Cabezas-Cartes F, Kubisch EL, Sinervo B, Ibargüengoytía NR. 2014. Changes In Female Reproduction And Body Condition In An Endemic Lizard, Phymaturus spectabilis, Following The Puyehue Volcanic Ashfall Event. Herpetological Conservation and Biology:11. Species of the Bi-Week: Lobo F, Barrasso DA, Hibbard T, Quipildor M, Slodki D, Valdecantos S, Basso NG. 2021. Morphological and Genetic Divergence within the Phymaturus payuniae Clade (Iguania: Liolaemidae), with the Description of Two New Species. South American Journal of Herpetology 20:41. Other Mentioned Papers/Studies: Becker, L. A., Boretto, J. M., Cabezas-Cartes, F., Márquez, S., Kubisch, E., Scolaro, J. A., ... & Ibargüengoytía, N. R. (2019). An integrative approach to elucidate the taxonomic status of five species of Phymaturus Gravenhorst, 1837 (Squamata: Liolaemidae) from northwestern Patagonia, Argentina. Zoological Journal of the Linnean Society, 185(1), 268-282. Cabezas-Cartes F, Kubisch EL, Ibargüengoytía NR. 2014. Consequences of volcanic ash deposition on the locomotor performance of the Phymaturus spectabilis lizard from Patagonia, Argentina: Effect Of Volcanic Ash In Locomotion Of Lizards. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 321:164–172. DOI: 10.1002/jez.1846. Other Links/Mentions: Frog call of Boana faber from Rodrigo Dela Rosa – https://amphibiaweb.org/cgi/amphib_query?special=call&genus=Boana&species=faber Editing and Music: Podcast edited by Emmy – https://www.fiverr.com/emmyk10  Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

In this episode of K9 Conservationists, Kayla speaks with Misa Winters and Tara Wilson about laboratory analysis of scat after field collection. Science Highlight: Duration of urination does not change with body size What can we learn from our scat samples? Genetic analysis (what species, what individual, what did it eat, sex typing) Morphological diet analysis (fur, bones, teeth, plants, insects) Microbiome (bacteria and immune system interaction) Parasites, pathogen analysis (bacteria and viral disease) Hormonal analysis (stress, pregnancy, nutrition, relative age) Age (isotope data) Hormones in particular are great from scat because it is more representative of an animal over time, versus a blood sample which is a smaller snapshot in time and could be skewed by the stress of capturing or darting an animal. What questions from samples are harder/easier to answer? Easier: Species ID from mitochondrial DNA (if you have good reference data) Prey analysis (if you have a targeted strategy - e.g. it's hard to use a single genetic marker to analyze ALL prey but it depends on if you're looking for mammals, birds, fish, etc.) Pregnancy (but actually need three assays estrogen, testosterone, and progesterone which can also point to a juvenile or adult). Stress - is it nutritional or environmental (T3 or cortisol) Harder: Individual capture-mark-recapture since it uses nuclear DNA and relies on a good resampling scheme. How many animals are on the landscape? Especially when using prey data, you have to make a lot of assumptions about how many predators can eat from the same prey species. We also know that DNA from prey is not equally represented after digestion, it will depend on the tissue ingested too. Where to find Misa Winters:  Website | Instagram | Lab Instagram Where to find Tara Wilson: Instagram You can support the K9 Conservationists Podcast by joining our Patreon at patreon.com/k9conservationists. K9 Conservationists Website | Merch | Support Our Work | Facebook | Instagram | TikTok

The gang discusses two taxonomy papers about dinosaurs, fulfilling their contractual obligation to produce one dinosaur-centric podcast every 8 to 10 years. The first paper finds strong evidence to support the validity of Torosaurus as a genus separate from Triceratops and is quite cool. The second paper is that awful T-rex paper from about a month ago. Meanwhile, Curt remembers too much, Amanda enjoys self-righteous fury, James goes too far, and we all get way too drunk and rambley for our own good. CONTENT WARNING: This episode gets very salty and pushes past our usual frequency of just a few expletives per podcast. You have been warned.   Up-Goer Five (Curt Edition): Our friends talk about two papers that look at big angry animals with no hair from the past. The first paper looks at a type of big angry animal that had a big thing coming out of the back of its head. There are a lot of these types of animals, but there are two of these types that have been a problem for some time. Some people think that these two types are two different things. However, some other people think that there is just one type and we are seeing the same animal get old and calling that old animal a new type that isn't real. This paper looks at some new parts from this other type that some people think is just one type that is old. They find that the parts show the animal was not old by looking at how the hard parts grow. This means that the two types have to be different and not the same. They also talk about the other parts of the animal that do not make sense if these two types are the same. So they show that we should instead see these as two different types of angry animals with a big thing coming out of the back of their heads. The second paper is bad and no one should read it.   References: Paul, Gregory S., W. Scott Persons,  and Jay Van Raalte. "The Tyrant Lizard King, Queen and Emperor: Multiple  Lines of Morphological and Stratigraphic Evidence Support Subtle  Evolution and Probable Speciation Within the North American Genus  Tyrannosaurus." Evolutionary Biology (2022): 1-24. Mallon, Jordan C., et al. "The record of Torosaurus (Ornithischia: Ceratopsidae) in Canada and its taxonomic implications." Zoological Journal of the Linnean Society (2022).

Paleontologists propose in a controversial paper that the beloved T rex is actually three different species — T rex, T regina, and T imperator. While the authors lay out morphological differences to support their reclassification, not all experts agree. ThePrint's Sandhya Ramesh explains the findings. Subscribe to the Pure Science Telegram Channel https://t.me/PureScienceWithSandhyaRamesh Supplementary reading: Paul et al., Evolutionary Biology (2022). The Tyrant Lizard King, Queen and Emperor: Multiple Lines of Morphological and Stratigraphic Evidence Support Subtle Evolution and Probable Speciation Within the North American Genus Tyrannosaurus https://link.springer.com/article/10.1007/s11692-022-09561-5

Conflicts in genetic phylogenetic trees and morphological phylogenetic trees pose a big problem for common ancestry.

Get .1 ASHA CEU hereEpisode Summary:This just in! Students do better when they are engaged and motivated! Okay... maybe that's not a newsflash for you, but perhaps you haven't yet thought about the role of engagement and motivation in academics, specifically writing endeavors for students who struggle with language. In this week's episode, Dr. Robin Danzack of Emerson College in Boston floods the podcast newswaves with her expertise on the role of “authentic” student writing intervention in school-based SLP practice. Tune in to discover why you should be thinking about writing (specifically “authentic” writing) as an SLP and how you can join forces with your fellow educators to integrate meaningful, dual-purpose, curriculum-based, writing interventions into your assessment and support practices. Got any comic book or video game fans on your caseload? You'll get some great tips to further bolster your existing strength as an SLP in customizing interventions to meet your students' unique needs and interests while fostering growth in language and literacy, simultaneously. As with many thought-provoking episodes in the Nerdcast library, you won't take your ear off this one, and I guarantee you'll leave inspired to weave writing into the fabric of your language intervention, and to spread the news across the virtual or physical break room!Learn more about Robin hereLearning Outcomes1. Explain the value of “authentic writing” to promote student engagement, motivation, and sociocultural-linguistic identity. 2. Analyze a student writing sample for microstructural vs. macrostructural features.3. Connect writing goals to language and speech outcomes, as well as to grade-level curriculum and learning standards. ReferencesCollins, G., & Wolter, J. A. (2019). Morphological awareness strategies to promote academic success at tier 1 through interprofessional collaboration. Perspectives of the ASHA Special Interest Groups, 4, 781-789.Danzak, R. L. (2011). Defining identities through multiliteracies: ELL teens narrate their immigration experiences as graphic stories. Journal of Adolescent and Adult Literacy, 55, 187-196.Harris, R. K. (2008). Powerful writing strategies for all students. Paul H. Brookes.Kamhi, A. G., & Catts, H. W. (2012). Language and reading disabilities (3rd ed.). Boston, MA: Pearson.Moll, L. C., Amanti, D., Neff, D., & González, N. (1992). Funds of knowledge for teaching: Using a qualitative approach to connect homes and classrooms. Theory into Practice, 21 (2), 132–141.Schuele, C. M., & Boudreau, D. (2008). Phonological awareness intervention: Beyond the basics. Language, Speech, and Hearing Services in Schools, 39, 3-20.Ukrainetz, T. A. (2015). Telling a good story: Teaching the structure of narrative. In T. A. Ukrainetz (Ed.), School-age language intervention: Evidence-based practices, pp. 335-377. Austin, TX: Pro-Ed. Westby, C. (2014). A language perspective on executive functioning, metacognition, and self-regulation in reading. In C. A. Stone, E. R. Silliman, B. J. Ehren, & G. P. Wallach (Eds.), Handbook of language and literacy: Development and disorders (2nd ed.), pp. 339-358. New York, NY: Guilford Press.Online Resources:ASHA Position statement on Reading and Writing in Children and Adolescents: https://www.asha.org/policy/ps2001-00104/Self-Regulated Strategy Development (SRSD): https://www.thinksrsd.com/Comic Life Software: http://plasq.com/apps/comiclife/macwin/Disclosures:Robin Danzak Financial Disclosures: Robin is an employee of Emerson College. Robin Danzak non-financial disclousres: Robin is a member of ASHA and the corresonding SIG 14. Kate Grandbois financial disclosures: Kate is the owner / founder of Grandbois Therapy + Consulting, LLC and co-founder of SLP Nerdcast. Kate Grandbois non-financial disclosures: Kate is a member of ASHA, SIG 12, and serves on the AAC Advisory Group for Massachusetts Advocates for Children. She is also a member of the Berkshire Association for Behavior Analysis and Therapy (BABAT), MassABA, the Association for Behavior Analysis International (ABAI) and the corresponding Speech Pathology and Applied Behavior Analysis SIG. Amy Wonkka financial disclosures: Amy is an employee of a public school system and co-founder for SLP Nerdcast. Amy Wonkka non-financial disclosures: Amy is a member of ASHA, SIG 12, and serves on the AAC Advisory Group for Massachusetts Advocates for Children. Time Ordered Agenda:10 minutes: Introduction, Disclaimers and Disclosures20 minutes: Descriptions of “authentic writing” to promote student engagement, motivation15 minutes: Descriptions of microstructural vs. macrostructural features10 minutes: Descriptions of writing goals to language and speech outcomes5 minutes: Summary and ClosingDisclaimerThe contents of this episode are not meant to replace clinical advice. SLP Nerdcast, its hosts and guests do not represent or endorse specific products or procedures mentioned during our episodes unless otherwise stated. We are NOT PhDs, but we do research our material. We do our best to provide a thorough review and fair representation of each topic that we tackle. That being said, it is always likely that there is an article we've missed, or another perspective that isn't shared. If you have something to add to the conversation, please email us! Wed love to hear from you!__SLP Nerdcast is a podcast for busy SLPs and teachers who need ASHA continuing education credits, CMHs, or professional development. We do the reading so you don't have to! Leave us a review if you feel so inclined!We love hearing from our listeners. Email us at info@slpnerdcast.com anytime! You can find our complaint policy here. You can also:Follow us on instagramFollow us on facebookWe are thrilled to be listed in the Top 25 SLP Podcasts!Thank you FeedSpot!

This week on UnDisciplined, we're talking about movement. Our first guest is a scientist whose research is helping us understand the ways the world's largest animal moves its body. Our second guest is a researcher whose recent studies uncover the ways animals are moved as part of complex global trafficking networks.