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What AI Knows Before You Draw the First LineAI site feasibility analysis is changing how architects evaluate land before design begins. In this episode of the EntreArchitect Podcast, Mark R. LePage talks with Gayathri (G3) Venkataraman, Founder and CEO of GeoProspex.ai, about how artificial intelligence is helping architects and developers make better decisions before the first line is drawn. Drawing on decades of AI leadership at Microsoft and DocuSign, G3 explains how practical AI tools can reduce uncertainty early in the design process.G3 shares how GeoProspex.ai combines proprietary AI models with trusted data sources to speed up site feasibility while protecting privacy and improving accuracy. She explains why architects should think of AI as a decision support tool rather than a replacement for professional judgment. As a result, teams can identify opportunities and risks in minutes instead of days.The conversation explores what AI means for the future of architecture, real estate, and construction. G3 discusses how firms can begin using AI today without changing everything at once. This episode offers practical insights for architects who want to work smarter, reduce project risk, and embrace new technology with confidence.This week at EntreArchitect Podcast, What AI Knows Before You Draw the First Line with Gayathri (G3) Venkataraman. Connect with G3 online at GeoProspex.ai, contact her at g3@geoprospex.ai, or find her on LinkedIn and Instagram.If you're ready to grow a stronger architecture business, join Brian McCartney and Mark R. LePage for a free live 60-minute webinar introducing EntreArchitect Academy, the business school for architects. You'll learn the proven systems and strategies firm owners are using to build profitable, sustainable practices. Register at EntreArchitect.com/Academy-Webinar.Referenced in this EpisodeEA615: Gayathri (G3) Venkataraman – AI for Site Feasibility: Streamlining Zoning, Codes, and Permits for ArchitectsPlease Visit Our Platform SponsorsARCAT makes finding architectural product information simple. Access specifications, CAD details, BIM objects, and sustainability documentation from thousands of manufacturers—all free, with no paywalls or registration required. Explore the platform architects trust every day at ARCAT.com.WeCollabify is one of EntreArchitect's trusted allied partners, helping architecture firms build capacity through integrated design, BIM, and technical professionals who work directly within your team. Their goal to help firm owners create the capacity they need to better serve clients, support their teams, and make confident long-term growth decisions. Learn more at WeCollabify.com/EntreArchitect.Visit our Platform Sponsors today and thank them for supporting YOU... The EntreArchitect Community of small firm architects.
In today's episode, we spoke with Solange Peters, MD, PhD. Dr Peters is a full professor, and chair of medical oncology and the thoracic malignancies programme in the Department of Oncology at the University Hospital of Lausanne in Switzerland. In our exclusive interview, Dr Peters discussed the rationale for pairing antiangiogenic activity with checkpoint inhibition upfront in non–small cell lung cancer (NSCLC), rather than sequencing them. She noted that prior attempts to combine or sequence bevacizumab (Avastin) with checkpoint inhibitors yielded only modest signals, hampered by bevacizumab's long half-life and class-specific toxicities including bleeding risk that historically excluded patients with squamous cell carcinoma. By contrast, PD-L1/VEGF bispecifics such as pumitamig carry a significantly shorter half-life of approximately 5 to 6 days, resulting in a similar toxicity category but with lower rates of high-grade events and a broadened eligible population.She highlighted the mechanistic rationale for this combination, explaining that VEGF and PD-L1 co-targeting appears to remodel the tumor microenvironment cooperatively, bringing cancer cells into closer proximity with T cells. In the case of PD-L1/VEGF bispecifics, a macromolecular structure forms in the tumor microenvironment that leads to internalization of PD-L1, creating a dual blockade of the PD-1/PD-L1 pathway beyond simple receptor occupancy.Dr Peters then discussed data presented at the 2026 ASCO Annual Meeting from the phase 2/3 ROSETTA Lung-02 trial (NCT06712316) evaluating pumitamig plus chemotherapy in the first-line setting. She described the activity observed across all PD-L1 expression strata, including in PD-L1–negative patients, who comprised up to 70% of the nonsquamous population and achieved response rates above 50% as particularly compelling. She also addressed the dose selection rationale, noting that the 1500-mg dose demonstrated the optimal pharmacodynamic activity and favorable risk-benefit profile for phase 3 advancement.Finally, Dr Peters offered broader perspective on the increasingly competitive PD-L1/VEGF bispecific landscape, including the parallel development of ivonescimab. She suggested that differences in clinical trial design including patient population, inclusion and exclusion criteria, and end point ambition may ultimately differentiate agents more than mechanism alone, and emphasized that global data will be essential to shaping regulatory and clinical practice decisions.
Exorcist, Fr Chad Ripperger, sits down and explains why we are seeing this intense rise in extremism in our modern times. From Socialism and communism to pronoun battles and the divisions in the family and the Church, there is more to this than you may realize. Fr. Ripperger also explains what the "antidote" to this really is and what the trajectory of all this is looking like. -------------------------------- Join the HEALING LIFE'S HURTS Online Summit HERE: https://brcoalition.com/SUMMIT/ -------------------------------- Buy the book First Line of Defense by Doug Barry & Daniel O'Connor HERE: https://ignatius.com/first-line-of-defense-fldfp/?cjdata=MXxOfDB8WXww&AID=15734493&PID=100357191&cjevent=d8410aea701111f181b400820a82b832 -------------------------------- Join the USGF Community HERE: http://joingraceforce.com/4ABL -------------------------------- CHECK OUT THE NEW USGF T-SHIRT - SALVE REGINA - HERE: https://ty19f5-gu.myshopify.com/products/salve-regina-graphic-t-shirt-elegant-marian-devotional-tee -------------------------------- Get your ONE NATION UNDER GOD T-Shirt (several different colors) HERE: https://ty19f5-gu.myshopify.com/products/one-nation-under-god-t-shirt-american-flag-tee -------------------------------- Get the 250 YEARS STRONG T-Shirt (a variety of colors) HERE: https://ty19f5-gu.myshopify.com/products/1776-under-one-god-patriotic-t-shirt-250-years-strong?variant=47926345105602 -------------------------------- Get the world famous USGF HAT HERE: https://ty19f5-gu.myshopify.com/products/us-grace-force-embroidered-baseball-cap?variant=47926654959810 -------------------------------- Join this channel to get access to perks: https://www.youtube.com/channel/UCKZ9OefEJLEx1qYcBxgAFww/join -------------------------------- PATREON - Help support this podcast by becoming a US Grace Force PATRON here: https://www.patreon.com/user?u=25398590 -------------------------------- Check out ROMAN CATHOLIC GEAR and get amazing Catholic gear for the battle of your life! Click HERE: https://romancatholicgear.com/USGF -------------------------------- Subscribe to our NEW US Grace Force YouTube channel! US GRACE FORCE 2.0. Don't miss any new, great content!! https://youtube.com/@USGraceForce2.0?si=zq47qEqPITXnIDkg -------------------------------- Get some GREAT Gloria Patri coffee HERE: https://gloriapatri.com/discount/GRACEFORCE -------------------------------- PRAY THE ROSARY: The Rosary of the Seven Sorrows of Mary: https://www.youtube.com/watch?v=DUr5UzrV63I -------------------------------- The Joyful Mysteries: https://www.youtube.com/watch?v=aMAR9MEN1pE&t=656s --------------------------------- The Sorrowful Mysteries: https://www.youtube.com/watch?v=XHUkx66oAxE&t=311s --------------------------------- The Glorious Mysteries: https://www.youtube.com/watch?v=Pg_JWsxS6EA&t=207s --------------------------------- The Luminous Mysteries: https://www.youtube.com/watch?v=PVL5CqBr3CA&t=198s --------------------------------- The Full Rosary: https://www.youtube.com/watch?v=44zL1kFIvP8&t=1765s --------------------------------- The seven promises given to St Bridget of Sweden for those who devote themselves to her Seven Sorrows. 1. I will grant peace to their families. 2. They will be enlightened about the Divine Mysteries. 3. I will console them in their pains, and I will accompany them in their work. 4. I will give them as much as they ask for as long as it does not oppose the adorable will of my Divine Son or the sanctification of their souls. 5. I will defend them in their spiritual battles with the infernal enemy and I will protect them at every instant of their lives. 6. I will visibly help them at the moment of their death—they will see the face of their mother. 7. I have obtained this grace from my divine Son, that those who propagate this devotion to my tears and dolors will be taken directly from this earthly life to eternal happiness, since all their sins will be forgiven and my Son and I will be their eternal consolation and joy.
In today's episode, we spoke with Sara M. Tolaney, MD, MPH, about the FDA approval of sacituzumab govitecan plus pembrolizumab (Keytruda) or pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex) for the first-line treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumors express PD-L1 as determined by an FDA-authorized test. Dr Tolaney is chief of the Division of Breast Oncology and associate director of the Susan F. Smith Center for Women's Cancers and a senior physician at Dana-Farber Cancer Institute, as well as an associate professor of medicine at Harvard Medical School in Boston, Massachusetts.This regulatory decision was backed by findings from the phase 3 ASCENT-04/KEYNOTE-D19 trial (NCT05382286), in which the median progression-free survival among patients in the sacituzumab govitecan arm was 11.2 months (95% CI, 9.3-16.7) vs 7.8 months (95% CI, 7.3-9.3) among patients who received physician's choice of chemotherapy plus pembrolizumab (HR, 0.65; 95% CI, 0.51-0.84; P = .0009).In our exclusive interview, Dr Tolaney highlighted the significance of this approval, key data from ASCENT-04, and how the TNBC paradigm is shifting to accommodate this new regimen.
Cases of diabolical problems are on the rise in America. Many people will testify that they think something is different in our world today and it doesn't feel good. Dr Dan Schneider joins us to shed some light on the ways that the Devil is staring us right in the face, in plain sight, and what we can and must do to respond. -------------------------------- Find out more about Dr Dan Schneider HERE: https://holyleagueinstitute.com/ https://tanbooks.com/products/books/the-liber-christo-method-a-field-manual-for-spiritual-combat/?afmc=7e https://tanbooks.com/products/books/spiritual-warfare-q-and-a-for-priests-and-laity/?afmc=7e https://tanbooks.com/products/books/sins-of-the-father-a-catholic-and-biblical-approach-to-generational-curses/?afmc=7e -------------------------------- Join the HEALING LIFE'S HURTS Online Summit HERE: https://brcoalition.com/SUMMIT/ -------------------------------- Buy the book First Line of Defense by Doug Barry & Daniel O'Connor HERE: https://ignatius.com/first-line-of-defense-fldfp/?cjdata=MXxOfDB8WXww&AID=15734493&PID=100357191&cjevent=d8410aea701111f181b400820a82b832 -------------------------------- Join the USGF Community HERE: http://joingraceforce.com/4ABL -------------------------------- CHECK OUT THE NEW USGF T-SHIRT - SALVE REGINA - HERE: https://ty19f5-gu.myshopify.com/products/salve-regina-graphic-t-shirt-elegant-marian-devotional-tee -------------------------------- Get your ONE NATION UNDER GOD T-Shirt (several different colors) HERE: https://ty19f5-gu.myshopify.com/products/one-nation-under-god-t-shirt-american-flag-tee -------------------------------- et the 250 YEARS STRONG T-Shirt (a variety of colors) HERE: https://ty19f5-gu.myshopify.com/products/1776-under-one-god-patriotic-t-shirt-250-years-strong?variant=47926345105602 -------------------------------- Get the world famous USGF HAT HERE: https://ty19f5-gu.myshopify.com/products/us-grace-force-embroidered-baseball-cap?variant=47926654959810 -------------------------------- Join this channel to get access to perks: https://www.youtube.com/channel/UCKZ9OefEJLEx1qYcBxgAFww/join -------------------------------- PATREON - Help support this podcast by becoming a US Grace Force PATRON here: https://www.patreon.com/user?u=25398590 -------------------------------- Check out ROMAN CATHOLIC GEAR and get amazing Catholic gear for the battle of your life! Click HERE: https://romancatholicgear.com/USGF -------------------------------- Subscribe to our NEW US Grace Force YouTube channel! US GRACE FORCE 2.0. Don't miss any new, great content!! https://youtube.com/@USGraceForce2.0?si=zq47qEqPITXnIDkg -------------------------------- Get some GREAT Gloria Patri coffee HERE: https://gloriapatri.com/discount/GRACEFORCE -------------------------------- PRAY THE ROSARY: The Rosary of the Seven Sorrows of Mary: https://www.youtube.com/watch?v=DUr5UzrV63I -------------------------------- The Joyful Mysteries: https://www.youtube.com/watch?v=aMAR9MEN1pE&t=656s --------------------------------- The Sorrowful Mysteries: https://www.youtube.com/watch?v=XHUkx66oAxE&t=311s --------------------------------- The Glorious Mysteries: https://www.youtube.com/watch?v=Pg_JWsxS6EA&t=207s --------------------------------- The Luminous Mysteries: https://www.youtube.com/watch?v=PVL5CqBr3CA&t=198s --------------------------------- The Full Rosary: https://www.youtube.com/watch?v=44zL1kFIvP8&t=1765s --------------------------------- The seven promises given to St Bridget of Sweden for those who devote themselves to her Seven Sorrows. 1. I will grant peace to their families. 2. They will be enlightened about the Divine Mysteries. 3. I will console them in their pains, and I will accompany them in their work. 4. I will give them as much as they ask for as long as it does not oppose the adorable will of my Divine Son or the sanctification of their souls. 5. I will defend them in their spiritual battles with the infernal enemy and I will protect them at every instant of their lives. 6. I will visibly help them at the moment of their death—they will see the face of their mother. 7. I have obtained this grace from my divine Son, that those who propagate this devotion to my tears and dolors will be taken directly from this earthly life to eternal happiness, since all their sins will be forgiven and my Son and I will be their eternal consolation and joy.
We're joined with Steve Ray, Catholic convert and pilgrimage leader, talks about grandparents and their role in the faith life of their grandchildren. Steve Ray, Catholic convert and pilgrimage leader, talks about grandparents and their role in the faith life of their grandchildren. Doug Barry, author of First Line of Defense: The Catholic Man's Call to Heroism.
Featuring an interview with Prof Dr Sibylle Loibl, including the following topics: Perspectives on overall survival gains achieved over the years for patients with metastatic breast cancer (mBC) (0:00) Previous treatment and patient outcomes in the DESTINY-Breast09 trial of trastuzumab deruxtecan (T-DXd) with or without pertuzumab (5:35) Role of endocrine therapy in the treatment of hormone receptor-positive, HER2-positive mBC (8:01) Targeting the PI3K signaling pathway in HER2-positive mBC (11:08) Contraindications for T-DXd; T-DXd-associated gastrointestinal toxicities and interstitial lung disease (13:53) Optimal duration of and therapeutic partner for T-DXd as first-line maintenance therapy for patients with HER2-positive mBC (20:44) Case: A woman in her early 40s with metastatic relapse of HER2-positive breast cancer 2 years after completing neoadjuvant and adjuvant therapy (26:54) Role of exercise and weight control in the management of breast cancer; effect of pregnancy on the breast tumor immune environment (40:03) CME information and select publications
Featuring a slide presentation and related discussion from Prof Dr Sibylle Loibl, including the following topics: · Overview of the changing landscape of treatment for patients with HER2-positive metastatic breast cancer (mBC) (0:00) · Results from the CLEOPATRA, PATINA and HER2CLIMB-05 trials of first-line treatment and maintenance approaches for HER2-positive mBC (5:26) · Efficacy and safety findings from the Phase III DESTINY-Breast09 trial comparing trastuzumab deruxtecan with or without pertuzumab to taxane/trastuzumab/pertuzumab as first-line therapy for HER2-positive mBC (14:56) · Predictors of long-term benefit from first-line treatment with HER2-targeted agents; contribution of pertuzumab to the efficacy of first-line HER2-targeted combination regimens (22:57) · Control of brain metastases and CNS disease with first-line HER2-targeted regimens (26:31) CME information and select publications
Exorcist, Fr. Carlos Martins, breaks down the dangers and traps that the devil presents to us in our modern world today and helps us find the path to safely get us through this mine field that we face. His book The Exorcist Files - https://www.amazon.com/dp/1546007652?lv=shuf&channelId=520&plpRedirect=mhFallback - is a powerful resource that helps prepare us to be relentless in our fight against the attacks of the enemy. -------------------------------- Get The Exorcist Files Book HERE: https://www.amazon.com/dp/1546007652?lv=shuf&channelId=520&plpRedirect=mhFallback -------------------------------- Join the HEALING LIFE'S HURTS Online Summit HERE: https://brcoalition.com/SUMMIT/ -------------------------------- Buy the book First Line of Defense by Doug Barry & Daniel O'Connor HERE: https://ignatius.com/first-line-of-defense-fldfp/?cjdata=MXxOfDB8WXww&AID=15734493&PID=100357191&cjevent=d8410aea701111f181b400820a82b832 -------------------------------- Join the USGF Community HERE: http://joingraceforce.com/4ABL -------------------------------- Get your ONE NATION UNDER GOD T-Shirt (several different colors) HERE: https://ty19f5-gu.myshopify.com/products/one-nation-under-god-t-shirt-american-flag-tee -------------------------------- Get the 250 YEARS STRONG T-Shirt (a variety of colors) HERE: https://ty19f5-gu.myshopify.com/products/1776-under-one-god-patriotic-t-shirt-250-years-strong?variant=47926345105602 -------------------------------- Get the world famous USGF HAT HERE: https://ty19f5-gu.myshopify.com/products/us-grace-force-embroidered-baseball-cap?variant=47926654959810 -------------------------------- Join this channel to get access to perks: https://www.youtube.com/channel/UCKZ9OefEJLEx1qYcBxgAFww/join -------------------------------- PATREON - Help support this podcast by becoming a US Grace Force PATRON here: https://www.patreon.com/user?u=25398590 -------------------------------- Check out ROMAN CATHOLIC GEAR and get amazing Catholic gear for the battle of your life! Click HERE: https://romancatholicgear.com/USGF -------------------------------- Subscribe to our NEW US Grace Force YouTube channel! US GRACE FORCE 2.0. Don't miss any new, great content!! https://youtube.com/@USGraceForce2.0?si=zq47qEqPITXnIDkg -------------------------------- Get some GREAT Gloria Patri coffee HERE: https://gloriapatri.com/discount/GRACEFORCE -------------------------------- PRAY THE ROSARY: The Rosary of the Seven Sorrows of Mary: https://www.youtube.com/watch?v=DUr5UzrV63I -------------------------------- The Joyful Mysteries: https://www.youtube.com/watch?v=aMAR9MEN1pE&t=656s --------------------------------- The Sorrowful Mysteries: https://www.youtube.com/watch?v=XHUkx66oAxE&t=311s --------------------------------- The Glorious Mysteries: https://www.youtube.com/watch?v=Pg_JWsxS6EA&t=207s --------------------------------- The Luminous Mysteries: https://www.youtube.com/watch?v=PVL5CqBr3CA&t=198s --------------------------------- The Full Rosary: https://www.youtube.com/watch?v=44zL1kFIvP8&t=1765s --------------------------------- The seven promises given to St Bridget of Sweden for those who devote themselves to her Seven Sorrows. 1. I will grant peace to their families. 2. They will be enlightened about the Divine Mysteries. 3. I will console them in their pains, and I will accompany them in their work. 4. I will give them as much as they ask for as long as it does not oppose the adorable will of my Divine Son or the sanctification of their souls. 5. I will defend them in their spiritual battles with the infernal enemy and I will protect them at every instant of their lives. 6. I will visibly help them at the moment of their death—they will see the face of their mother. 7. I have obtained this grace from my divine Son, that those who propagate this devotion to my tears and dolors will be taken directly from this earthly life to eternal happiness, since all their sins will be forgiven and my Son and I will be their eternal consolation and joy.
I sat down with Dr. Jordan Metzl, a sports-medicine physician who's convinced that the reason most of us can't stay consistent isn't discipline or knowledge, it's motivation, and he says you can actually engineer it by "lowering the cost to act." We get into exercise as a literal medicine that would beat almost any drug if it came in a pill, why fun is the real holy grail of compliance, and how movement can go head-to-head with antidepressants for everyday anxiety and depression. If you've been white-knuckling your way through willpower and losing, this one's going to change how you think about getting off the couch. CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Get Dr. Jordan Metzl's book, “Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity”: https://bit.ly/4f28xiO Connect with Dr. Jordan Metzl Website: https://bit.ly/4gzA0tp Instagram: https://bit.ly/4aRhbhA Facebook: https://bit.ly/4fdR45E X: https://bit.ly/4aP5Mig Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: "ULTIMATE20" FOR 20% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - Intro of Show 02:00 - From family of doctors to sports medicine 04:00 - Prescribing the medicine of exercise 05:55 - What an exercise prescription looks like 07:41 - The 1950s London Transport study 10:22 - Cellular adaptations and mitochondria 11:52 - Inflammation and chronic disease 13:31 - Immuno-fatigue and the theory of aging 14:45 - Motivation, not discipline, is missing 18:14 - Knowledge, emotion, and belief 20:25 - Building a fitness community 24:11 - Biomarkers and the cost of chronic disease 26:23 - Lifespan vs healthspan gap 28:26 - Fun is the holy grail of compliance 34:00 - Why remote work hurts our health 39:16 - Making exercise pay for doctors 41:01 - Two minutes of vigorous activity a day 44:30 - The GLP-1 and arthritic knee study 48:49 - Exercise vs antidepressants 55:38 - Lowering the cost to act 59:42 - What it means to be an Ultimate Human 1:01:29 - Alice: a marathon at 70 Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices
"The Arctic is the hardest operational environment on Earth for anybody. For any country." Dominion Dynamics CEO and BetaKit Most Ambitious honouree Eliot Pence joins to discuss his company's plans to become the general contractor for Canada's defence needs, why the Arctic is so important, and why he came back to Canada to build. -- Amid global uncertainty, the path forward is clear: Canada's moment to build is now. Presented by Uber Canada, DMZ, and National Bank of Canada, BetaKit Most Ambitious is back, telling stories of nearly 100 Canadian innovators strengthening our nation's autonomy, security, and prosperity. Read BetaKit Most Ambitious now.
As America celebrates its 250th anniversary it is good to look at where we have come from and where we are going. Joshua Charles, founder and president of Eternal Christendom, joins us to look at what we are seeing in our country today and what is genuinely good to be thankful for and what we should be very concerned about. -------------------------------- More about Joshua Charles and Eternal Christendom HERE: https://eternalchristendom.com/ -------------------------------- Buy the book First Line of Defense by Doug Barry & Daniel O"Connor HERE: https://ignatius.com/first-line-of-defense-fldfp/?cjdata=MXxOfDB8WXww&AID=15734493&PID=100357191&cjevent=d8410aea701111f181b400820a82b832 -------------------------------- Join the USGF Community HERE: http://joingraceforce.com/4ABL -------------------------------- Get your ONE NATION UNDER GOD T-Shirt (several different colors) HERE: https://ty19f5-gu.myshopify.com/products/one-nation-under-god-t-shirt-american-flag-tee -------------------------------- Get the 250 YEARS STRONG T-Shirt (a variety of colors) HERE: https://ty19f5-gu.myshopify.com/products/1776-under-one-god-patriotic-t-shirt-250-years-strong?variant=47926345105602 -------------------------------- Get the world famous USGF HAT HERE: https://ty19f5-gu.myshopify.com/products/us-grace-force-embroidered-baseball-cap?variant=47926654959810 -------------------------------- Join this channel to get access to perks: https://www.youtube.com/channel/UCKZ9OefEJLEx1qYcBxgAFww/join -------------------------------- PATREON - Help support this podcast by becoming a US Grace Force PATRON here: https://www.patreon.com/user?u=25398590 -------------------------------- Check out ROMAN CATHOLIC GEAR and get amazing Catholic gear for the battle of your life! Click HERE: https://romancatholicgear.com/USGF -------------------------------- Subscribe to our NEW US Grace Force YouTube channel! US GRACE FORCE 2.0. Don't miss any new, great content!! https://youtube.com/@USGraceForce2.0?si=zq47qEqPITXnIDkg -------------------------------- Get some GREAT Gloria Patri coffee HERE: https://gloriapatri.com/discount/GRACEFORCE -------------------------------- PRAY THE ROSARY: The Rosary of the Seven Sorrows of Mary: https://www.youtube.com/watch?v=DUr5UzrV63I -------------------------------- The Joyful Mysteries: https://www.youtube.com/watch?v=aMAR9MEN1pE&t=656s --------------------------------- The Sorrowful Mysteries: https://www.youtube.com/watch?v=XHUkx66oAxE&t=311s --------------------------------- The Glorious Mysteries: https://www.youtube.com/watch?v=Pg_JWsxS6EA&t=207s --------------------------------- The Luminous Mysteries: https://www.youtube.com/watch?v=PVL5CqBr3CA&t=198s --------------------------------- The Full Rosary: https://www.youtube.com/watch?v=44zL1kFIvP8&t=1765s --------------------------------- The seven promises given to St Bridget of Sweden for those who devote themselves to her Seven Sorrows. 1. I will grant peace to their families. 2. They will be enlightened about the Divine Mysteries. 3. I will console them in their pains, and I will accompany them in their work. 4. I will give them as much as they ask for as long as it does not oppose the adorable will of my Divine Son or the sanctification of their souls. 5. I will defend them in their spiritual battles with the infernal enemy and I will protect them at every instant of their lives. 6. I will visibly help them at the moment of their death—they will see the face of their mother. 7. I have obtained this grace from my divine Son, that those who propagate this devotion to my tears and dolors will be taken directly from this earthly life to eternal happiness, since all their sins will be forgiven and my Son and I will be their eternal consolation and joy.
Send us Fan MailIn this double-blind randomized controlled trial, Adrianne and Nim examine whether norepinephrine outperforms dopamine as a first-line vasoactive agent in neonates with fluid-refractory septic shock. The primary outcome, shock reversal at 30 minutes, was not significantly different between groups, at 32 percent for norepinephrine and 46 percent for dopamine. Secondary outcomes including mortality, IVH, NEC, and need for additional vasoactive support were also similar. The episode critically examines the methodological limitations of the study, including unclear sepsis definitions, absence of echo phenotyping, and unusually high starting doses, and asks whether the field needs better tools before these questions can be properly answered.----Norepinephrine versus Dopamine for Septic Shock in Neonates: A Randomized Controlled Trial.Mazhari MYA, Priyadarshi M, Singh P, Chaurasia S, Basu S.J Pediatr. 2025 Jul;282:114599. doi: 10.1016/j.jpeds.2025.114599. Epub 2025 Apr 17.PMID: 40252959 Clinical Trial.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
The attacks against the Catholic Church have always been, but in recent decades we have seen an increase in these attacks and a concerning rise in violence and persecution in different forms around the world. Daniel O'Connor joins us to break this down and discuss if Christians, especially men, are truly ready for what is happening and for what may be coming. -------------------------------- Buy the book First Line of Defense HERE: https://ignatius.com/first-line-of-defense-fldfp/?cjdata=MXxOfDB8WXww&AID=15734493&PID=100357191&cjevent=d8410aea701111f181b400820a82b832 -------------------------------- Join the USGF Community HERE: http://joingraceforce.com/4ABL -------------------------------- Get your ONE NATION UNDER GOD T-Shirt (several different colors) HERE: https://ty19f5-gu.myshopify.com/products/one-nation-under-god-t-shirt-american-flag-tee -------------------------------- Get the 250 YEARS STRONG T-Shirt (a variety of colors) HERE: https://ty19f5-gu.myshopify.com/products/1776-under-one-god-patriotic-t-shirt-250-years-strong?variant=47926345105602 -------------------------------- Get the world famous USGF HAT HERE: https://ty19f5-gu.myshopify.com/products/us-grace-force-embroidered-baseball-cap?variant=47926654959810 -------------------------------- Join this channel to get access to perks: https://www.youtube.com/channel/UCKZ9OefEJLEx1qYcBxgAFww/join -------------------------------- PATREON - Help support this podcast by becoming a US Grace Force PATRON here: https://www.patreon.com/user?u=25398590 -------------------------------- Check out ROMAN CATHOLIC GEAR and get amazing Catholic gear for the battle of your life! Click HERE: https://romancatholicgear.com/USGF -------------------------------- Subscribe to our NEW US Grace Force YouTube channel! US GRACE FORCE 2.0. Don't miss any new, great content!! https://youtube.com/@USGraceForce2.0?si=zq47qEqPITXnIDkg -------------------------------- Join the US Grace Force Team HERE: https://visitor.r20.constantcontact.com/manage/optin?v=001ESuSGaJpYPCG2iUdd4j4bkKwd4gkh2ZUVbam_Ty9rCn6blH6_U3cI2D8UvSLEcSzHnC4eq2UWmK1I0SbEw0SPKqnkZ2j0Z4J4D-_m4dD6CKJU9day-bBa8Qnx4dv7RLDIVlYAjL1JWsjfUTNPH2jQIVY9gbdbz4O4oMIzv5V1dT_upQsD8cX86iq_5Y-x4eLrTVtdOmA24s%3D&fbclid=IwY2xjawFRvvdleHRuA2FlbQIxMAABHdo526R1rgNAIW76yyQnVbo957e1TgOoQ4RH3Tr84D8376Y7jng09gtlOw_aem_H7Y7Ej6cF6-nPyfOZ4qMTQ -------------------------------- PRAY THE ROSARY: The Rosary of the Seven Sorrows of Mary: https://www.youtube.com/watch?v=DUr5UzrV63I -------------------------------- The Joyful Mysteries: https://www.youtube.com/watch?v=aMAR9MEN1pE&t=656s --------------------------------- The Sorrowful Mysteries: https://www.youtube.com/watch?v=XHUkx66oAxE&t=311s --------------------------------- The Glorious Mysteries: https://www.youtube.com/watch?v=Pg_JWsxS6EA&t=207s --------------------------------- The Luminous Mysteries: https://www.youtube.com/watch?v=PVL5CqBr3CA&t=198s --------------------------------- The Full Rosary: https://www.youtube.com/watch?v=44zL1kFIvP8&t=1765s --------------------------------- Be Ready Emergency Preparedness Course: Be prepared to Care for and Protect your Family in times of Natural Disasters, Emergencies, Civil Unrest, Economic Collapse, and more. Sign up for the course HERE: https://brcoalition.com/ --------------------------------- Go HERE to check out the BR Coalition and get great training Body, Mind & Soul! https://brcoalition.com/ Become part of one of the fastest growing online Catholic Membership sites. --------------------------------- Get your hands on some great US Grace Force T-shirts! https://us-grace-force.creator-spring.com/ --------------------------------- The seven promises given to St Bridget of Sweden for those who devote themselves to her Seven Sorrows. 1. I will grant peace to their families. 2. They will be enlightened about the Divine Mysteries. 3. I will console them in their pains, and I will accompany them in their work. 4. I will give them as much as they ask for as long as it does not oppose the adorable will of my Divine Son or the sanctification of their souls. 5. I will defend them in their spiritual battles with the infernal enemy and I will protect them at every instant of their lives. 6. I will visibly help them at the moment of their death—they will see the face of their mother. 7. I have obtained this grace from my divine Son, that those who propagate this devotion to my tears and dolors will be taken directly from this earthly life to eternal happiness, since all their sins will be forgiven and my Son and I will be their eternal consolation and joy.
In this episode of Joint Ventures, hosts Jack Arnold, MBBS, PhD, academic clinical lecturer in rheumatology, University of Leeds, was joined at the European Alliance of Associations for Rheumatology (EULAR) 2026 annual congress in London by Laurence Duquenne, MD, a rheumatology researcher, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, an investigator on one of the meeting's standout studies to examine whether baseline naïve CD4+ T cell frequency can identify which newly diagnosed patients with rheumatoid arthritis (RA) are unlikely to respond to methotrexate monotherapy, and whether adding a biologic at the outset can close that gap.Click here to watch the episode.
If you think of the play as a continuation of what has already happened, it gives you a sense of how much work you have to do in order to earn the play. Excerpted from my New York class, we continue our work on the Frank Gilroy play, The Subject Was Roses.
Featuring an interview with Prof Martin Reck, including the following topics: Case: A woman in her mid 70s with extensive-stage small cell lung cancer (ES-SCLC) experiences a strong response to first-line chemoimmunotherapy and maintenance lurbinectedin/atezolizumab (0:00) Biology of small cell lung cancer and pharmacodynamics of systemic treatment (3:25) Considerations with maintenance therapy for ES-SCLC (9:31) Considerations with immunotherapy for ES-SCLC (13:12) Curability of SCLC with systemic therapy (15:17) Data with chemoimmunotherapy for patients with poor performance status (25:55) Future developments in therapy for SCLC (30:11) Rapid fire: Small Cell 101 (35:45) CME information and select publications
Featuring a slide presentation and related discussion from Prof Martin Reck, including the following topics: Overview of small cell lung cancer (SCLC) (0:00) First-line chemoimmunotherapy for extensive-stage SCLC (ES-SCLC) (3:50) Lurbinectedin as first-line maintenance therapy for ES-SCLC (12:36) Case: A man in his early 60s with ES-SCLC receives first-line atezolizumab/carboplatin/etoposide followed by maintenance lurbinectedin/atezolizumab (18:46) Case: A woman in her mid 70s with ES-SCLC experiences a strong response to first-line chemoimmunotherapy and maintenance lurbinectedin/atezolizumab (21:21) CME information and select publications
This week, we go back to Classical Hematology! We previously discussed the initial workup and management of ITP in Episode 009, but now it's time to dig deeper. What do we do once we make the diagnosis? How do we approach management when we have a new diagnosis? Content: - Refresher on diagnosis of ITP- Response criteria - What warrants a hospital admission vs. outpatient management? - What is our approach to initial inpatient management? - When is it safe to discharge a patient from the hospital?** Want to review the show notes for this episode and others? Check out our website. Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Youtube
“As iron sharpens iron, so one person sharpens another” (Proverbs 27:17). Get your copy of the “First Line of Defense” here: https://ignatius.com/first-line-of-defense-fldfp/?searchid=0&search_query=first+line+of+defense Many are aware of today's “crisis of masculinity,” and so we are grateful to be joined by Doug Barry and Daniel O'Connor to discuss how men can become spiritually and physically prepared for the big and small battles ahead. After assessing the current state of masculinity in our culture, they offer words of encouragement and wisdom on how to become a better and more Godly man. They encourage men to take responsibility and to take action both in their personal life and as leaders in their family. This requires preparedness, training, and spiritual as well as physical exercise. This uplifting discussion is a great source of encouragement for men who want to grow stronger and closer to God. SUBSCRIBE to our channel and never miss an episode of the Ignatius Press Podcast. You can also listen to the podcast on Apple, Spotify, and other podcast platforms. Follow us on social media: Twitter/X: https://twitter.com/IgnatiusPress Facebook: https://www.facebook.com/ignatiuspress Instagram: https://www.instagram.com/ignatius_press/
Episode 206. Join me for a behind-the-scenes look at a typical day in outpatient psychiatry as a resident, with some honest, mini-rants about note-writing and medications vs. psychotherapy. I also discuss my strategies for maintaining work-life balance and give advice for medical students applying to residency.Learn more about the Medical Student CV Masterclass: https://www.firstlinepodcast.com/courseAccess the exclusive MCAT Cram Session Series: Subscribe to First Line on Spotify creators.spotify.com/pod/profile/firstline/subscribeEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn USMLE or COMLEX subscription go to https://truelearn.referralrock.com/l/firstline/ and use the code firstline at checkoutContent on First Line is for educational and informational purposes only and not intended to be used as medical advice. Views expressed are my own and do not represent any organizations I am associated with.
Optimize CLL and MCL care: experts discuss the latest data on sequencing and personalizing therapies across all lines of treatment to improve outcomes. Credit available for this activity expires: 06/12/2027 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/chronic-lymphocytic-leukemia-data-driven-updates-first-line-2026a1000imb?ecd=bdc_podcast_libsyn_mscpedu
Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Small Cell Lung Cancer | Faculty Presentation 1: Limited-Stage Small Cell Lung Cancer (SCLC); First-Line and Maintenance Therapy for Extensive-Stage SCLC — Jacob Sands, MD CME information and select publications
Is your gastroesophageal adenocarcinoma (GEA) treatment plan ready for the latest human epidermal growth factor receptor 2 (HER2) innovations? Credit available for this activity expires: 05/29/2027 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/ready-launch-gastroesophageal-adenocarcinoma-anti-her2-2026a1000gtw?ecd=bdc_podcast_libsyn_mscpedu
CME credits: 0.25 Valid until: 01-06-2027 Claim your CME credit at https://reachmd.com/programs/cme/chairpersons-perspective-reframing-first-line-and-subsequent-care-in-advanced-urothelial-carcinoma-clinical-implications-of-the-updated-nccn-guidelines/54396/ This 15-minute online CME activity reviews the clinical implications of the updated NCCN Guidelines for advanced urothelial carcinoma (aUC), with a focus on evolving first-line and subsequent treatment strategies. The program highlights the shift away from cisplatin eligibility as the primary determinant of frontline therapy selection and examines key clinical trial data that inform current practice. Participants will explore sequencing considerations following frontline therapy as well as the role of biomarker-directed therapies in later lines of care. The activity also emphasizes early recognition and management of treatment-related adverse events alongside strategies for dose modification and supportive care. Multidisciplinary coordination and shared decision-making are discussed as essential components of optimizing patient-centered care in aUC.=
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3024: Ryan Larson explains how honest, structured conversations about money can strengthen relationships and prevent financial conflict from becoming a long-term problem. By exploring financial history, debt, assets, future goals, and ongoing communication, couples can build trust, create shared plans, and approach finances as a team instead of adversaries. Read along with the original article(s) here: https://firstlinefin.com/how-to-have-the-money-talk-with-your-partner/ Quotes to ponder: "Money and finances are routinely sited as the number one topic couples fight about and one of the leading causes of divorce." "It's important to keep an open mind and be willing to compromise. The point isn't “my way or the highway,” it's “what works for us.”" "Remember, it's you two against the problem, not you two against each other." Episode references: IRA: https://www.irs.gov/retirement-plans/individual-retirement-arrangements-iras 401(k): https://www.investor.gov/introduction-investing/general-resources/news-alerts/alerts-bulletins/investor-bulletins-16 Learn more about your ad choices. Visit megaphone.fm/adchoices
Clean claims are more than a submission goal — they are one of the strongest defenses against avoidable A/R. In this RCMinutes segment, we look at how better claim quality reduces downstream follow-up, prevents unnecessary delays, and gives revenue cycle teams more time to focus on the accounts that truly need attention.
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 4028: Ryan Larson explores why growth begins the moment you step beyond what feels safe. Through personal stories and practical examples, he shows how embracing discomfort builds confidence, sharpens your mind, and reveals strengths you never knew you had. Read along with the original article(s) here: https://firstlinefin.com/challenges-comfort-zones/ Quotes to ponder: “Challenges are what make life interesting and overcoming them is what makes life meaningful.” “Fear is built in your nervous system as a survival instinct. So, it's always going to be there, you just have to deal with it.” “Winning isn't where the growth lives, leaping is where the magic happens.” Episode references: Toastmasters International: https://www.toastmasters.org/ Tony Robbins: https://www.tonyrobbins.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 4028: Ryan Larson explores why growth begins the moment you step beyond what feels safe. Through personal stories and practical examples, he shows how embracing discomfort builds confidence, sharpens your mind, and reveals strengths you never knew you had. Read along with the original article(s) here: https://firstlinefin.com/challenges-comfort-zones/ Quotes to ponder: “Challenges are what make life interesting and overcoming them is what makes life meaningful.” “Fear is built in your nervous system as a survival instinct. So, it's always going to be there, you just have to deal with it.” “Winning isn't where the growth lives, leaping is where the magic happens.” Episode references: Toastmasters International: https://www.toastmasters.org/ Tony Robbins: https://www.tonyrobbins.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 4028: Ryan Larson explores why growth begins the moment you step beyond what feels safe. Through personal stories and practical examples, he shows how embracing discomfort builds confidence, sharpens your mind, and reveals strengths you never knew you had. Read along with the original article(s) here: https://firstlinefin.com/challenges-comfort-zones/ Quotes to ponder: “Challenges are what make life interesting and overcoming them is what makes life meaningful.” “Fear is built in your nervous system as a survival instinct. So, it's always going to be there, you just have to deal with it.” “Winning isn't where the growth lives, leaping is where the magic happens.” Episode references: Toastmasters International: https://www.toastmasters.org/ Tony Robbins: https://www.tonyrobbins.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Episode 205. Let's break down why conferences are a powerful but often overlooked part of the medical school experience, from early exposure to specialties to building meaningful connections in medicine. We also explore how these experiences can strengthen your path toward residency and help you think more strategically about your ERAS application.Learn more about the Medical Student CV Masterclass: https://www.firstlinepodcast.com/courseAccess the exclusive MCAT Cram Session Series: Subscribe to First Line on Spotify creators.spotify.com/pod/profile/firstline/subscribeEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn USMLE or COMLEX subscription go to https://truelearn.referralrock.com/l/firstline/ and use the code firstline at checkoutContent on First Line is for educational and informational purposes only and not intended to be used as medical advice. Views expressed are my own and do not represent any organizations I am associated with.
In the depths of the Castle Eschatonica, the true beckonings called to the travelers of the Dragon Path. Led across the ether under divine shadow and holy light, to things that aren't, but which might yet be: New more peaceful lives. Freedom from obligation and duty. Different, more adventurous histories. A key to a door which itself beckons. The power to protect those they care for. Power for power's sake alone. With these behind them, the two groups re-emerge into the halls of the Castle. In the western wing, three figures push forward into the passageways of this transcendent fortress—Uncle Nicky, criminal turned chef; the terrapine Jonathan, inventor and—now—airship captain; and Antistrophe Landrace, the Ruinbringer, though he may not know it yet. Meanwhile, to the east, an octet walks Eschatonica's twisting paths: Famed adventurer, and Jonathan's sister, Maebela; Veile Lyndelle, destined devotee of the Ennead; Elena Millefiori, Tesserae chanter and eager traveler; the youthful and curious Waylon of Spillaway Peaks; Renegade Hexcloak Caiomhe Wake; and finally, Brontë Adelvys, dissipated sixth scion of the First Line, along with his attendants, Efta and Zolfta Above them, watching with all nine eyes, is Gnova, once the God of Distant Color and Light, now the steward of this Castle. But they are not the only celestial being interested in Eschatonica. They saw Lucena's sunlight streamed across the ether towards their home. They watched as Caliginia's long shadow fell, finally, even here. Indeed, they dread how these gods now shake the diorama-like stability of Eschatonica, and how in doing so, they unknowingly have sent up a flare… Because she is coming, now. Indeed. She is almost here. This Week on Perpetua: Escape the Rumbling Castle! 01 Perpetua Guide [In Progress v.06] NPCs & Monsters [PNMS] Thanks to TheUnforgivenIII for pushing me to include a little more info in the NPCs & Monsters section! Still not giving it all away, because my goal isn't to take away all the mystery! But you should check TU3's strategy guide (in progress) for more combat focused tips! Windborne Hawk Traits: Agile, Lightweight, Droning Type: Hunter Construct Level: 10 Rank: Soldier Stats: DEX 10, INS 8, MIG 6, WLP 8 Attacks: Flechette Burst Special Abilities: Occult Dampener, Annoying Buzz, Flying Elemental Affinities: IMM: Poison | RES: Wind, Dark, Earth | VUL: Bolt, Ice, Light In-Game Description: A beautiful bird automaton that floats through the power of a dark wind. Despite being level 10 soldiers, these are one of the most dangerous enemies in the Castle Eschatonica. They are custom made to crush your casters (which according to DoomTreeAnne's lore document really lines up with their anti-Oracle purpose in Armidirge). Their Flechette Burst can tear through your party (especially characters without martial armor!!) and their Occult Dampener turn them into spell-devouring TANKS. Starter Tip: Take. These. Down. Quick. Once their Dampener is up, they're that much harder to deal with. Windborne Turret Traits: Automatic, Threat-Finding, Defensive, Deployed Type: Hunter Construct Level: 10 Rank: Soldier Stats: DEX 8, INS 10, MIG 8, WLP 6 Attacks: Repeating Fire Special Abilities: None Elemental Affinities: IMM: Poison | RES: Wind, Dark, Earth | VUL: Bolt, Light In-Game Description: A hovering, bronze-clad weapon that scans for (and eliminates) targets Extremely straightforward enemies. They float in place (but AREN'T Flying enemies) and take a really strong shot at you every other turn (and it doesn't seem like they do much in the way of supporting the rest of their side). Exploit that to keep their total attack Starter Tip: Focus them down, one at a time. Windborne Flower Traits: Automatic, Defensive, Deployed Type: Support Construct Level: 10 Rank: Soldier Stats: DEX 8, INS 8, MIG 8, WLP 8 Attacks: Shadow Cast Special Abilities: Barrier of Wind, Flying Elemental Affinities: IMM: Poison | RES: Wind, Dark, Earth | VUL: Bolt, Fire, Light In-Game Description: Like a bronze flower, this device unfurls its petals and emits a shielding over its allies. These are the de facto "clerics" of these Windborne automata. Their Barrier of Wind is super annoying (though it should be recognizable if you're doing a support Elene build!). Starter Tip: While they don't do a lot of damage, their Shadow Cast ability can leave your party dazed, so be careful! Eaja, Windborne Hawkmaster Traits: Fierce, Quick, Determined, Principled Type: Sentinel Humanoid Rank: Champion (3) Stats: DEX ??, INS ??, MIG ??, WLP ?? Attacks: Unknown Special Abilities: Unknown Elemental Affinities: Unknown In-Game Description: A scout from the Windborne Church, one of the two major factions of Armidirge. Thankfully, you don't need to fight Eaja along with her automatons when you first bump into her, though if you're quick you can tackle her as an optional boss fight (which is really hard). Starter Tip: Leave her for later! Trust me. Hosted by Austin Walker (austinwalker.bsky.social) Featuring Ali Acampora (ali-online.bsky.social), Art Martinez-Tebbel (amtebbel.bsky.social), Jack de Quidt (notquitereal.bsky.social), Janine Hawkins (@bleatingheart), Sylvi Bullet (@sylvibullet), Keith J Carberry (@keithjcarberry) and Andrew Lee Swan (swandre3000.bsky.social) Produced by Ali Acampora Music by Jack de Quidt (available on bandcamp) Cover Art by Ben McEntee (https://linktr.ee/benmce.art) With thanks to Amelia Renee, Arthur B., Aster Maragos, Bill Kaszubski, Cassie Jones, Clark, DB, Daniel Laloggia, Diana Crowley, Edwin Adelsberger, Emrys, Greg Cobb, Ian O'Dea, Ian Urbina, Irina A., Jack Shirai, Jake Strang, Katie Diekhaus, Ken George, Konisforce, Kristina Harris Esq, L Tantivy, Lawson Coleman, Mark Conner, Mike & Ruby, Muna A, Nat Knight, Olive Perry, Quinn Pollock, Robert Lasica, Shawn Drape, Shawn Hall, Summer Rose, TeganEden, Thomas Whitney, Voi, chocoube, deepFlaw, fen, & weakmint This episode was made with support from listeners like you! To support us, you can go to friendsatthetable.cash.
May is Mental Health Awareness Month — and I wanted to do something that felt real rather than performative. So I called a suicidologist. His name is Mark Kaplan, and he has spent his career studying why people die by suicide: the data, the risk factors, the gaps in how we think about prevention, and what any of us can actually do. This conversation is personal for me and I think it will be for most of you, too. We cover the numbers (they're staggering), why so many people we lose don't fit the profile we expect, what the research actually says about warning signs, and what upstream prevention means — practically, not as a policy abstraction. If you've ever been touched by this — directly or indirectly — this one's for you.If you or someone you love is struggling, help is available 24/7 — call or text 988 to reach the Suicide and Crisis Lifeline.00:00:03 Introduction & Context 00:01:11 What Is Suicidology 00:03:33 Origins of the Field & 988 00:05:59 Mark's Personal Entry 00:08:17 Silent Suicides 00:10:39 Upstream vs. Downstream 00:13:05 The Numbers: 50,000 a Year 00:15:27 Why the Rate Is Still Rising 00:17:46 Social Media's Role 00:19:53 80% of Suicides Are Men 00:22:16 Older Adults & Not Being a Burden 00:24:42 Veterans & Suicide 00:26:58 Global Comparisons 00:29:07 Risk Factors Deep Dive 00:31:30 Precipitating Events & Leslie's Story 00:33:56 Behavioral Warning Signs 00:36:16 Red Flag Laws & Firearms Policy 00:38:42 The Window Problem 00:41:03 What Mark Would Change 00:43:28 Harm Reduction & Mental Health 00:45:49 Universal Prevention 00:48:08 Primary Care as First Line 00:50:57 What You Can Actually Do 00:53:18 Loneliness, Social Media & ClosingHosted on Ausha. See ausha.co/privacy-policy for more information.
New cardiovascular data suggest pulsed field ablation may challenge antiarrhythmic drugs as first-line therapy for persistent atrial fibrillation, while real-world evidence positions apixaban as the preferred DOAC for younger patients with nonvalvular AF due to superior safety and effectiveness. Additional findings from the SENIOR-RITA trial indicate that routine invasive management may not benefit frail older adults with NSTEMI and could worsen outcomes in the most frail patients. Together, these studies highlight a growing shift toward more individualized cardiovascular treatment strategies.
Episode 204. Let's break down the best practices for volunteering in medical school, including how to choose experiences that create real impact beyond just adding hours to your CV. We discuss meaningful service opportunities, mentorship, community engagement, and how volunteering helps shape both your medical training and your future as a physician.Learn more about the Medical Student CV Masterclass: https://www.firstlinepodcast.com/courseAccess the exclusive MCAT Cram Session Series: Subscribe to First Line on Spotify creators.spotify.com/pod/profile/firstline/subscribeEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn USMLE or COMLEX subscription go to https://truelearn.referralrock.com/l/firstline/ and use the code firstline at checkoutContent on First Line is for educational and informational purposes only and not intended to be used as medical advice. Views expressed are my own and do not represent any organizations I am associated with.
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2031: Ryan Larson shares practical ways to navigate the constant tension between career demands and family life by focusing on what truly matters and setting intentional boundaries. By reconnecting with your “why,” protecting your energy, and creating meaningful routines, you can show up more fully in both roles without guilt. Read along with the original article(s) here: https://firstlinefin.com/family-and-work-a-balancing-act/ Quotes to ponder: "You can't be everything to everyone, let your best be your best." "If your tank is only half-full, how can you show up 100% for those you love?" "Finally, give yourself a little grace. You're doing much better than you think." Episode references: Start With Why TED Talk: https://www.ted.com/talks/simon_sinek_how_great_leaders_inspire_action Learn more about your ad choices. Visit megaphone.fm/adchoices
In this podcast episode, Erika Hamilton, MD, FASCO, and Ian Krop, MD, PhD, discuss recent developments in the field of first-line therapy and maintenance treatment for patients with HER2-positive metastatic breast cancer, including the following: Trastuzumab deruxtecan plus pertuzumab as first-line therapy based on data from DESTINY-Breast09 Adding palbociclib to HP and ET as maintenance therapy for HR-positive/HER2-positive MBC, based on data from PATINA Adding tucatinib to HP as maintenance therapy for HER2-positive MBC, based on data from HER2CLIMB-05 Presenters: Erika Hamilton, MD, FASCO Chief Development Officer, Late Phase Director, Breast Cancer Research Program Sarah Cannon Research Institute (SCRI) Nashville, Tennessee Ian Krop, MD, PhD Professor of Medicine, Yale School of Medicine Associate Cancer Center Director for Clinical Research Yale Cancer Center New Haven, Connecticut Content based on an online CME program supported by an educational grant from Pfizer. Link to full program: https://bit.ly/4esvN9x Get access to all our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
A Podcast from Obstetrics & Gynecology highlighting the latest research and practice updates in the field. This episode features an interview with Dr. Irogue I. Igbinosa, author of "Intravenous Ferumoxytol Compared With Oral Ferrous Sulfate for Iron Deficiency Anemia in Pregnancy: A Randomized Controlled Trial."
Featuring perspectives from Dr Virginia F Borges and Dr Ian E Krop, including the following topics: Introduction: Biology of "Triple-Positive" Breast Cancer; Implications for Therapeutic Development (0:00) Cases from the GMO Survey (13:01) First-Line Therapy for Metastatic HER2-Positive Disease (20:01) Maintenance Therapy for HR-Positive, HER2-Positive Disease (30:03) Maintenance Therapy for HR-Negative, HER2-Positive Disease (46:30) Cases from the GMO Survey (50:00) CME information and select publications
Dr Virginia F Borges from the University of Colorado Anschutz Medical Campus in Aurora and Dr Ian E Krop from Yale Cancer Center in New Haven, Connecticut, review clinical research data and best practices guiding the selection of first-line and maintenance therapy for patients with ER-positive, HER2-positive metastatic breast cancer. CME information and select publications here.
Episode 203. Let's break down exactly what types of leadership experiences medical students should pursue each year of medical school to build a strong ERAS application for residency. Using my own journey as an example, I share a practical roadmap for getting involved early and progressing strategically. Ready to add leadership experiences to you CV? Learn more about the Medical Student CV Masterclass: https://www.firstlinepodcast.com/courseEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesAccess the exclusive MCAT Cram Session Series: Subscribe to First Line on Spotify creators.spotify.com/pod/profile/firstline/subscribeFor a discount on your TrueLearn USMLE or COMLEX subscription go to https://truelearn.referralrock.com/l/firstline/ and use the code firstline at checkoutContent on First Line is for educational and informational purposes only and not intended to be used as medical advice. Views expressed are my own and do not represent any organizations I am associated with.
Drs. Isaacs and Traina discuss DESTINY-Breast09, where first‑line T‑DXd + pertuzumab clearly outperforms the CLEOPATRA regimen in progression-free survival for metastatic HER2+ breast cancer. They focus on the dilemma of when to use T‑DXd: earlier, for maximal efficacy, or later, to protect quality of life and manage ILD and cardiac risks.
Grab your mixtapes and Walkman and put on your sparkly brain hats. It's Jay vs. Gen-X! Today, Shayne quizzes Jay on his knowledge of 80s Music lyrics. Round 306!Thanks to Audrey Engvalson for this article: I'm Challenging All Of Gen-X To Identify These Classic '80s Songs From The Lyrics, And It's Kind Of DifficultPlease support us on the Beer Thursday Patreon page!At the $10 level, the next 18 Great Human Beings will get access to the Beer Thursday Facebook group.Never miss a round and be a part of our journey to the top by subscribing and leaving a 5-star review on your favorite podcasting app. Your support means the world to us!~~~~~~~~~~Here's what our house elf, Artie (not Archie), says about this round: Spring into '80s Music: Trivia Showdown & Classic Hits Join Shayne and Jay on Beer Thursday as they dive into an unexpected '80s music trivia challenge! With a springtime backdrop, the duo tests their knowledge of iconic '80s song lyrics from artists such as The Human League, Whitney Houston, Prince, and others. With engaging discussions, fun banter, and surprising music facts—like the latest on Tears for Fears and hidden gems from Cyndi Lauper's early band days—this episode promises to be a nostalgic trip down memory lane. Perfect for Gen X-ers and '80s music aficionados alike. Tune in for laughs, music, and a healthy dose of friendly competition!
Ready to break through your Keto or low carb plateau? Book your free consultation call with Robert Sikes here: https://www.ketobodybuilding.com/callYou are sabotaging your own health goals without even realizing it. Your shallow breathing and high stress levels are destroying your digestion, blocking fat burning, and leading to hormone imbalances. The key to improving your health isn't just about what you eat, but how your body functions from the inside out.In episode 867 of the Savage Perspective Podcast, host Robert Sikes sits down with Dr. John Douillard to reveal how ancient Ayurvedic wisdom holds the answers to modern health problems like metabolic syndrome and fatigue. They explore how simple changes in your breathing can improve your lymphatic system, reset your digestion, and create lasting energy. This episode provides the tools you need to stop fighting your body and finally work with it to achieve your best state of health.Follow Dr. John Douillard on IG: https://www.instagram.com/lifespa/Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQChapters0:00 - The Optimal Intermittent Fasting Window For Fat Loss0:58 - How an Ironman Triathlon Led to A Surprising Discovery3:16 - The "Eye of the Storm" Secret for Peak Performance5:22 - How Nasal Breathing Scientifically Unlocks The "Runner's High"6:29 - Why Life Feels Like a Struggle (And How to Fix It)8:23 - The Unexpected Habit That Boosts Athletic Power10:29 - The Science of "Calm Amidst Chaos" for Elite Performance12:36 - What Is Ayurveda? A Beginner's Guide13:19 - How Seasonal Eating Optimizes Your Gut Microbiome15:34 - The Forgotten System Key to Longevity16:30 - Is Brain Fog Linked to a Congested Brain?18:13 - Why Most Athletes Have a Weak Diaphragm (And Don't Know It)20:51 - Are Food Intolerances a Myth? The Real Cause23:15 - Is 1g of Protein Per Pound of Bodyweight a Fad?25:07 - The Single Biggest Lever to Pull for Better Digestion27:13 - How to Properly Practice Breathwork for Maximum Benefit28:03 - Are You "Over-Breathing"? The Signs of Oxygen Inefficiency29:07 - The Perfect Storm for Anxiety (And How to Reverse It)30:00 - A Message From Robert Sikes31:40 - How Your Mental State Affects Nutrient Absorption32:21 - What is Metabolic Syndrome and What Truly Causes It?35:12 - The Real Reason for PMS Symptoms (It's Not Hormones)37:14 - What Is The Optimal Meal Frequency for Digestion?38:45 - The Truth About Intermittent Fasting: Breakfast vs. Supper43:03 - One Meal a Day (OMAD): Pros and Cons46:16 - TRT & HRT: Are They a First Line of Defense?50:00 - How to Test The Health of Your Lymphatic System at Home50:35 - How to Preserve Your Nitric Oxide Production52:41 - The Ancient Ayurvedic Tool for Oral Health55:20 - Dr. Douillard's Daily Morning Routine for Longevity59:31 - Dr. Douillard's Evening Wind-Down Routine1:02:15 - Where to Find Dr. John Douillard
This episode focuses on some simple personal safety habits and everyday awareness tips that can help people stay safer in public, along with a quick update on the Glock 19 Gen 6 after time on the range.
Most Etsy listings lose buyers in the first few seconds. Not because the product is bad… but because the shopper never realizes they're in the right place. In this episode, I break down the one sentence every listing needs at the very top, a simple line that instantly tells a shopper: "Yes, this is exactly what you're looking for." We'll talk about how to pull that sentence directly from your customer reviews, how to echo the voice of your happiest buyers, and why most sellers accidentally bury their most persuasive message deep in their description where no one sees it. Mastermind Sign up - (CLOSES IN APRIL) - https://docs.google.com/forms/d/1OhqSM2PDzXVfTduuBQVHLNqffezP66IWqdvwZ21O4js/edit#responses
Raymundo sings us the first line of a famous 90's country song and all we have to do is name the song. It is so much harder than you think because of his limited singing abilities! In the Anonymous Inbox, Bobby helps a listener who accidentally found out her co-worker makes more money than her for doing the same job. How can she bring it up to her boss even though she found out by accident? We talked about parents who are letting their 13 year old drop out of school to play video games full-time.See omnystudio.com/listener for privacy information.
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