Podcasts about First Line

Navigating the Evolving Landscape of Cybersecurity and AI: In-Depth Insights from Rick JordanIn this episode of The Thoughtful Entrepreneur, host Josh Elledge talks with Rick Jordan, speaker, coach, and Founder & CEO of ReachOut Technology. Rick unpacks the rapidly changing worlds of cybersecurity and artificial intelligence, and how business leaders can stay proactive in protecting their organizations. With practical advice, personal stories, and big-picture strategy, Rick shares what it really takes to succeed—and stay secure—in a digital-first world.Exploring the Human and Technical Sides of CybersecurityThe conversation begins on a personal note as Rick shares how technology, particularly gaming, creates meaningful connections with his daughter. Josh adds how gaming fosters deeper bonds in his own family, highlighting the positive impact of shared digital experiences. This sets the stage for the bigger conversation—how the human element influences technology, cybersecurity, and communication.Rick explains how ReachOut Technology addresses cybersecurity for small and mid-sized businesses by offering enterprise-level solutions through a clear and trusted brand. He shares his unique growth-by-acquisition strategy, integrating smaller IT service providers to create a unified, scalable, and culturally aligned company. He also outlines how his team helps SMBs implement practical steps like MFA, employee security training, and credit freezes to reduce risks from modern cyber threats.A consistent theme throughout the episode is the power of communication—whether between parents and kids or tech leaders and their teams. Rick emphasizes that cybersecurity is as much about people as it is about technology. His mission is to equip leaders with both the technical knowledge and communication skills needed to safeguard their organizations in an AI-driven world.About Rick Jordan:Rick Jordan is a nationally recognized speaker, coach, and cybersecurity expert. As the CEO of ReachOut Technology, Rick is committed to simplifying cybersecurity for SMBs and helping leaders take practical steps to protect their teams. He's also a media personality and author, using his platform to educate and inspire through books, interviews, and keynotes.About ReachOut Technology:ReachOut Technology is a managed IT and cybersecurity company that provides enterprise-level protection and support to small and mid-sized businesses. Through a unique acquisition strategy and customer-focused approach, ReachOut is creating a household name in the fragmented IT space.Links Mentioned in this Episode:Rick Jordan's WebsiteRick Jordan on LinkedInReachOut Technology WebsiteEpisode Highlights:The personal and professional ways technology fosters connectionHow ReachOut Technology is scaling through strategic acquisitionsThe biggest cybersecurity threats and why phishing remains a top concernWhy MFA and security awareness training are no longer optionalThe importance of communication in driving cultural change around cybersecurityConclusionJosh and Rick's conversation bridges the gap between technology and human behavior. From protecting digital assets to creating stronger family connections, Rick emphasizes the need for both technical tools and empathetic...

Janie is a certified Physician Assistant (PA-C) with a passion for getting to the root of health issues.  With over ten years in primary care, she has seen firsthand how the healthcare system often fell short when it came to prevention and long-term wellness. To better serve her patients, Janie earned certifications in nutrition (Precision Nutrition Level 1) and strength coaching for those with special health considerations (Certified Special Populations Specialist).  This better equips her to address the need to educate people on sustainable, lifestyle-driven health solutions that are greatly lacking in conventional medicine.   She strives to empower people with practical strategies and sustainable habits that support long-term physical and mental well-being. She believes that when people understand and own their health, they unlock a better way of living that makes them stronger, healthier, and more resilient. What we talk about in this episode: GLPs now FIRST LINE(?!) for weight loss??! Pills for every ill What the fuck are we doing We were freaks in PA school Pull-ups for prescription pads The presidential tests Who's funding the studies (and medical schools) Two things that will move the needle for your health How much do pharmacy reps make Why aren't strength coaches and dietitians doing lunch and learns? Diabetes med reps and Italian food What about CGMs? How I left my full-time job Getting kicked off the ticky tockies Learn more about working with me  Shop my masterclasses (learn more in 60-90 minutes than years of dr appointments) Follow me on IG Follow Empowered Mind + Body on IG  Learn more about working with Janie + Achieve The Lifestyle Follow Janie on IG  Follow Achieve The Lifestyle

Episode 178. This is a foundational episode of First Line that covers what it means to have a whole person, holistic approach to mental health and wellness (for you or your patients)! We also discuss the 6 pillars of lifestyle medicine and how each relates to the practice of psychiatry.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

In today's episode we will be ranking the top ten strongest characters in Naruto. This is a slightly subjective podcast with some people's opinions differing from ours. We did a messy job explaining the forms of these characters, so it is the characters STRONGEST form. Also, unlike we mention in the FIRST LINE, we are CLEARLY not ranking every Naruto character. It is a top ten list. Sorry about that.Rules:No Otsutsuki's will be included in this ranking.No Boruto characters will be included (characters who were born in Naruto who reached their peak in Boruto will be included in their Boruto forms)

Episode 177. We'll explore the science behind cannabis, including how it affects the brain and body. Learn about its potential medical uses for conditions like anxiety, chronic pain, and insomnia and what risks to be aware of.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

What if healing your body started with what you put on your plate?In this episode, I speak with Neka Pasquale, founder of Urban Remedy, whose background in Traditional Chinese Medicine inspired a revolutionary way to think about food. Neka shares how she went from private practice to building a national organic food brand rooted in healing, anti-inflammatory, and low-glycemic meals.We talk about the “food as medicine” philosophy, the reality of scaling a fresh-food company to over 370 locations, and the everyday rituals that keep her grounded while growing a purpose-driven brand. If you're a founder, a health seeker, or simply love hearing how someone builds from their passion—this one's for you.

Episode 176. Prevent picky eating and increase diet diversity by having your toddler try these foods! This is my list of different foods I gave my own toddler for the first time between 12 and 15 months of age.Here are some of the products I mentioned in this episode (some are affiliate links):Amaranth from Whole FoodsFonioBob's Red Mill TeffKidney Beans with no added saltTarget's Mixed Nut ButterNutty PuffsOrganic Sunflower ButterWhole Foods Frozen Cut OkraSoft-Dried Apricot from Trader Joe'sMy Favorite Fig Spread (All Natural)My Daughter 's Favorite Fruit Bar (Contains Fig) from TargetVisit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

In today's episode, we spoke with Paolo Tarantino, MD, about key updates in HER2-positive breast cancer presented at the 2025 ASCO Annual Meeting

The Looming Crisis Few Want to Confront Paul Daneshrad, CEO of StarPoint Properties and author of Money and Morons, is sounding the alarm: the United States is barreling toward a sovereign debt reckoning – and real estate professionals are not nearly prepared.   Citing economists Reinhart and Rogoff, along with voices as diverse as Jamie Dimon, Jerome Powell, and Ray Dalio, Daneshrad warns that the U.S. has not only crossed the 100% debt-to-GDP threshold, widely viewed as a critical danger zone, but has kept accelerating. "We're at 120 to 140% on-balance-sheet," he notes. "If you include off-balance-sheet liabilities, we're at 300%." While the exact timing of the crisis is unknowable, Daneshrad argues that its inevitability is not. “It's not a question of if – it's when.”   Politics, Populism, and Normalcy Bias Daneshrad is quick to dismiss the conventional partisan narrative. The deficit is no longer a left-right issue, it's a bipartisan affliction. Both political parties, he argues, are fueling structural imbalances. Worse, the electorate, while voicing concern, refuses to vote for hard choices.   This disconnect is the heart of his book's provocative title: Money and Morons. “86% of Americans say they're worried about the debt,” he says. “But they won't vote for politicians willing to solve it, because that solution involves pain.”   The result is what psychologists call “normalcy bias” – an instinct to ignore looming threats and retreat into the comfort of the familiar.   Fixed-Rate Fortresses: Real Estate's First Line of Defense If the debt crisis triggers hyperinflation and a spike in interest rates, as Daneshrad expects, the implications for real estate will be seismic. His response? Radical preparation.   StarPoint has already begun shifting its portfolio into 20+ year fixed-rate debt and is moving toward 30-year structures. “It's painful. It's more expensive. But if the crisis comes in eight years, and you've got two years left on a 10-year loan, you're vulnerable.”   He emphasizes that this is not a fringe view. “Even Powell, whose mandate doesn't include the deficit, felt compelled to warn the public. That's how serious it is.”   Deleveraging with Purpose Debt levels at StarPoint are also coming down – fast. The firm is targeting 40% leverage, down from a peak of 70%. They currently sit at 54%, and the journey continues.   The rationale is clear: when interest rates jump from 6% to 15%, the re-pricing of real estate will be brutal. “That's trillions in lost value,” says Daneshrad. “You have to de-risk now.”   The Forgotten Asset: Cash Cash, often derided for its lack of yield in boom times, plays a central role in Daneshrad's playbook. “The Rockefellers, Kennedys, Guggenheims – they had cash when it mattered. They bought at two cents on the dollar.”   Berkshire Hathaway's record cash holdings reinforce this strategy. “Buffett sees limited opportunity right now and high risk. That should tell you something.”   Daneshrad recommends targeting cash reserves as a percentage of either AUM or annual free cash flow, steadily building them over time. "Public companies get punished for it. Private firms like ours have more flexibility and we're using it."   Why He's Not Buying (Yet) Despite market dislocation, Daneshrad says StarPoint is mostly sitting on the sidelines. Cap rate spreads don't justify the risk, and few deals offer the deep value he's targeting.   “We're looking for rebound plays where sellers are on their third buyer and need certainty of close. That's where the discounts are. But those opportunities are rare.”   Asked whether the mispricing stems from short-term underwriting or optimism bias, he shrugs. “We've flooded the system with liquidity. Asset prices are artificially propped up.”   Diversification and the Limits of Real Estate Daneshrad is not betting the farm on U.S. real estate. He's pursuing modest geographic diversification abroad and expanding into non-real estate asset classes. “Historically, real estate hedges inflation well but a debt crisis changes everything.”   He's candid about the difficulty: “We're not that smart. Timing a crisis is hard. But we can prepare for one.”   The Aging America Conundrum One of the more nuanced points Daneshrad raises is the intersection of demography and fiscal sustainability. Aging, he agrees, is inevitable. But the care infrastructure it requires is not financially supported. “The trustees for Social Security and Medicare, not politicians, say the funds go bankrupt in under ten years. That's $90 trillion in off-balance-sheet liabilities.” Senior housing? “A great idea if the elderly can pay. But with savings rates at historic lows, I'm not optimistic.”   Market Signals That Matter Daneshrad watches for three early signs of crisis: A gradual rise in interest rates – not driven by Fed hikes but by market demands for higher risk premiums. Breakdown of the flight-to-safety dynamic – if equities fall but bond yields rise, that's a red flag. The ‘bang moment' – as coined by Reinhart and Rogoff, when confidence evaporates overnight. As Hemingway once said about bankruptcy, it happens "gradually, then suddenly."   What He'd Do with $1 Million Today If handed an extra million in cash, Daneshrad says he'd hold 80% in cash and invest the rest. “Protect the capital. Diversify over multiple asset classes. Liquidity is opportunity.”   Final Word Paul Daneshrad's message is sobering but clear: “Protect. Prepare. Don't pretend.” He doesn't claim to predict the future. But if you accept the warnings from the smartest voices in finance and economics, the case for defensive posturing is overwhelming.   And if they're wrong? You lose a few basis points. But if they're right you survive the bang.   *** In this series, I cut through the noise to examine how shifting macroeconomic forces and rising geopolitical risk are reshaping real estate investing.   With insights from economists, academics, and seasoned professionals, this show helps investors respond to market uncertainty with clarity, discipline, and a focus on downside protection.    Subscribe to my free newsletter for timely updates, insights, and tools to help you navigate today's volatile real estate landscape. You'll get: Straight talk on what happens when confidence meets correction - no hype, no spin, no fluff. Real implications of macro trends for investors and sponsors with actionable guidance. Insights from real estate professionals who've been through it all before. Visit GowerCrowd.com/subscribe Email: adam@gowercrowd.com Call: 213-761-1000

In this episode of The Non-Prophets, the panel reacts to the alarming halt in CDC communications, with the U.S. now flying blind on public health threats. Budget cuts, mass firings, and political meddling have silenced disease alerts that once informed doctors, hospitals, and the public. The team dives into how dismantling the CDC's outreach endangers lives, erodes trust in science, and shows contempt for evidence-based governance. It's not about public safety—it's about control.NPR, “CDC's public health warnings go dark after staff firings, media freeze”By Elijah Nouvelage, May 21, 2025https://www.npr.org/2025/05/21/nx-s1-5387723/cdc-communications-cuts-social-media-public-healthThe Non-Prophets 24.23.1 with Eli Slack, Kelley Laughlin, and AJAmerica's Disease Watchdog Has Gone Silent

Episode 175. Let's discuss what the normal grief process looks like, going through each of the 5 stages of grief with associated defense mechanisms. We'll also touch on the difference between the normal grief process and when it becomes pathological.This episode contains content about death and suicide.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Welcome to a special edition of We get work®, recorded live from Workplace Horizons 2025 in New York City, Jackson Lewis's annual Labor and Employment Law Conference. Over 500 representatives from 260 companies gathered together to share valuable insights and best practices on workplace law issues impacting their business today. Here's your personal invitation to get the insights from the conference, delivered directly to you.   

What can we say? We love a game!!! And dare I say, this may be the hardest one yet? Hailey takes the girls through a guessing game to see who has the best memory of the first few lines of our favorite reads! Play along, and see who comes on top! Join our book club for June! We are reading Blood Over Bright Haven by M.L. Wang, and will be discussing June 24th! Follow us on Instagram and TikTok for more content!

Episode 174. Ever since medical school, I have been making bowls with dark leafy greens as the foundation, and this is my favorite hack to make healthy whole-food meals on a budget and with limited time to cook. I share my personal favorite ingredients with tangible tips so you can make your own bowls and greatly increase your vegetable intake with less effort.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Drs Park and Malla began by talking through the clinical utility of ctDNA in patients with stage II and III colon cancer. Dr Malla referenced the DYNAMIC (ACTRN12615000381583) and observational BESPOKE CRC (NCT04264702) trials, noting that ctDNA serves as a prognostic biomarker for recurrence and is increasingly used to guide post-surgical surveillance.

Episode 173. Hear about the increasing evidence we have for how physical health and mental health are interrelated and why you can't truly have wellness in one area without the other. I bring my unique perspective as a psychiatry resident with osteopathic medicine training (DO) that focuses on the interconnection of body, mind, and spirit while offering ideas for lifestyle changes you can make today.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Episode 172. What do you feed your toddler after baby-led weaning ends? I share how I continued introducing a variety of foods to my child between 12 and 18 months, avoiding the picky-eater pitfalls and embracing realistic, sustainable meals beyond the baby phase—without the pressure of Pinterest-perfect bento boxes.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

In this episode, we get into some freight fraud trends that are more commonplace than double brokering. Our guest, Michael Grace, VP of Customer Risk Management at Highway breaks down how carrier sales reps and shippers can be a first line of defense against fraud.  For more information subscribe to Check Call the newsletter or the podcast. Follow the Check Call Podcast Other FreightWaves Shows Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we get into some freight fraud trends that are more commonplace than double brokering. Our guest, Michael Grace, VP of Customer Risk Management at Highway breaks down how carrier sales reps and shippers can be a first line of defense against fraud.  For more information subscribe to Check Call the newsletter or the podcast. Learn more about your ad choices. Visit megaphone.fm/adchoices

Drs. VanderPluym and Starling review the updated position statement from the American Headache Society indicating that CGRP-targeting migraine therapies should be considered as a first-line option.

Episode 171. Learn how to build a daily and weekly study plan to organize lectures, resources, Anki, and practice questions. I walk you through a system (including the number of practice to complete each day) that will help you ace your school exams while optimizing your success on Step 1.The giveaway has ended, but I still hope you rate and review First Line, share this episode on your Instagram story, and enroll in the Medical Student CV Masterclass. For more information about the masterclass, check out my episode from March 31st (episode 167) and then sign up at firstlinepodcast.com on the course tab. This is a course that provides a template specific for medical students and guides you step by step, section by section to craft a competitive CV that you can use for away rotations, letter of recommendation, dean's letters, research opportunities, leadership roles, an outline for your ERAS application, and whatever else comes your way as a medical student. I have years of experience helping students one on one and have helped hundreds of clients with the process of applying to away rotations and residency. This course unveils my proven method I have used to help students craft exceptional CVs that make them stand out.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): https://www.firstlinepodcast.com/servicesFor a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Episode 170. I'll share my top recommended resources for the USMLE Step 1, including specifics about the best question banks for Step 1. Plus, I'm giving away a brand-new copy of Crush Step 1! There are three ways to enter this special giveaway: 1. Rate on Spotify OR rate and review on Apple (5-stars please!) Screenshot and email me (firstlinepodcast@yahoo.com) or post on Instagram and tag me @fristlinepodcast2. Post the episode in your Instagram story (and tag me) with a key takeaway from the episode3. Sign up for the Medical Student CV Masterclass hereThe winner will be announced on May 12th, so you have until then to enter up to 3 times!Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): ⁠https://www.fiverr.com/firstlinepod⁠ For a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Featuring an interview with Dr Adam M Brufsky, including the following topics: Case: A woman in her early 50s with ER-positive, HER2-low de novo metastatic breast cancer (0:00) Case: A woman in her late 70s with ER-positive, HER2-low metastatic breast cancer after 5 years of an adjuvant aromatase inhibitor (6:52) Clinical Investigator Survey Results (10:05) CME information and select publications

Dr Adam M Brufsky from the University of Pittsburgh discusses first-line treatment selection for patients with HR-positive metastatic breast cancer and preexisting medical conditions. CME information and select publications here.

Featuring a slide presentation and related discussion from Dr Adam M Brufsky, including the following topics: Mechanism of action of and long-term data with CDK4/6 inhibitors in the management of metastatic breast cancer (mBC) (0:00) Comparing safety profiles of CDK4/6 inhibitors (9:49) Role of CDK4/6 inhibitors in therapy for older patients with mBC (24:06) Real-world evidence with CDK4/6 inhibitors (27:31) CME information and select publications

Interview with Benjamin N. Rome, MD, MPH, author of Use and Cost of First-Line Biologics to Treat Plaque Psoriasis in the US: Use of and Cost of First-Line Biologics to Treat Plaque Psoriasis in the US. Hosted byAdewole S. Adamson, MD. Related Content: Use and Cost of First-Line Biologic Medications to Treat Plaque Psoriasis in the US

Interview with Benjamin N. Rome, MD, MPH, author of Use and Cost of First-Line Biologics to Treat Plaque Psoriasis in the US: Use of and Cost of First-Line Biologics to Treat Plaque Psoriasis in the US. Hosted byAdewole S. Adamson, MD. Related Content: Use and Cost of First-Line Biologic Medications to Treat Plaque Psoriasis in the US

CME credits: 0.25 Valid until: 16-04-2026 Claim your CME credit at https://reachmd.com/programs/cme/first-line-chemotherapy-options-in-metastatic-pdac/33135/ Pancreatic ductal adenocarcinoma, also known as PDAC, is a lethal disease that is usually diagnosed at an advanced stage with an extremely poor prognosis. Advancements in treatment regimens have improved survival rates, but early diagnosis is crucial for improving outcomes, and awareness of risk factors is vital for early diagnosis. Cytotoxic chemotherapy is the cornerstone of treatment for advanced or metastatic cases, although molecularly targeted therapies and immunotherapies may benefit select patients. Treatment selection depends on several factors, including patients' performance status and comorbidities, which should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens. This two-part programme provides an overview of the different first- and second-line chemotherapy options. Complete both modules, answer pre- and post-test questions and start earning CME credits. This programme is also featured on the COR2ED website, here: Chemotherapy Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

Episode 169. Is coffee good for you? Can it fit into a healthy diet? Let's dive into the health benefits and potential risks of coffee, including its role in disease prevention and how many cups I've decided to have daily.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): ⁠https://www.fiverr.com/firstlinepod⁠ For a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

READY RADIO: First Line of Defense Against Unconstitutional Overreach 4.11.25 by John Rush

Featuring an interview with Dr Justin F Gainor, including the following topics: Duration of responses observed with ALK inhibitors in patients with ALK-positive metastatic non-small cell lung cancer (mNSCLC) (0:00) Current role of other systemic therapy options for the treatment of ALK-positive mNSCLC; management of oligometastatic disease (8:38) Local therapy approaches for treating CNS disease in ALK-positive mNSCLC (18:32) Tolerability profile of lorlatinib (23:28) Review of clinical investigator survey results (37:08) Novel ALK inhibitors under clinical development (53:22) CME information and select publications

Dr Justin F Gainor from Massachusetts General Hospital in Boston reviews available clinical data on ALK inhibitors and first-line treatment strategies for ALK-positive metastatic non-small cell lung cancer. CME information and select publications here.

Featuring a slide presentation and related discussion from Dr Justin F Gainor, including the following topics: Duration of responses observed with ALK inhibitors in patients with ALK-positive metastatic non-small cell lung cancer (mNSCLC) (0:00) Current role of other systemic therapy options for the treatment of ALK-positive mNSCLC; management of oligometastatic disease (8:38) Local therapy approaches for treating CNS disease in ALK-positive mNSCLC (18:32) Tolerability profile of lorlatinib (23:28) Review of clinical investigator survey results (37:08) Novel ALK inhibitors under clinical development (53:31) CME information and select publications

Episode 168. We explore how each Enneagram type can reflect traits of specific personality disorders in an unhealthy state and how knowing this can encourage self-awareness and personal growth.Visit First Line's website and blog: ⁠https://www.firstlinepodcast.comEditing Service for Pre-Med and Medical Students (CV, personal statement, applications): ⁠https://www.fiverr.com/firstlinepod⁠ For a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

In today's episode, supported by EMD Serono, we had the pleasure of speaking with Chandler Park, MD, about the first-line treatment of patients with bladder cancer. Dr Park is a medical oncologist at the Norton Cancer Institute in Louisville, Kentucky.  In our exclusive interview, Dr Park discussed the core regimens in the current frontline bladder cancer treatment paradigm, ways that this paradigm is expected to evolve in the coming months and years, and how the choice of frontline therapy influences treatment decision-making regarding subsequent lines of therapy.

Parenting teens today can feel like trying to hold back a tidal wave. We want to protect them, guide them, and set them up for success—but how do we do that without burning out or pushing them away? In this episode, we're tackling three crucial parenting strategies: Setting Boundaries with Technology—How to create limits that actually stick, without constant battles. Why Kids Don't Always Need Therapy, Parents Need to Learn Tools—Understanding when their struggles are really a reflection of their environment. Raising Independent Teens—How to help them take responsibility for their own lives instead of constantly relying on you to manage everything. If parenting feels like an uphill battle, there's a better way. Let's make it easier. Book a free Peaceful Parenting Call, and in 45 minutes, we'll create a plan that actually works for your family. About my guest: Nicole Runyon, LMSW, is an esteemed psychotherapist specializing in parenting, author, and keynote speaker renowned for her expertise in child and adolescent mental health, backed by an extensive 21-year career in the field. Nicole is also the mother of 2 children. You can find her book, Free to Fly right HERE Instagram and FB- @igenerationmentalhealth  LinkedIn- Nicole Runyon

Episode 167. Learn how to create a standout CV as a medical student with expert insights from someone who has successfully navigated the process and helped hundreds others do the same. Listen in to hear how to access my CV template crafted just for medical students.Visit https://www.firstlinepodcast.com/ to access the course tab for my NEW Medical Student CV Masterclass and the services tab to learn more about my one-on-one individualized editing services.For a discount on your TrueLearn subscription use ⁠https://truelearn.referralrock.com/l/firstline/⁠ and code firstlineContent on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

Join Professors Iain McInnes and Peter Nash for the latest episode on The Immune-Mediated Inflammatory Disease Forum, where they discuss the latest updates in RA. In this episode, they discuss two papers: effectiveness of JAKi compared with bDMARDs on pain reduction and effective second‑line b/tsDMARD for patients with rheumatoid arthritis unresponsive to first‑line b/tsDMARDs.

A phase 3 study showed that combining pelabresib with ruxolitinib significantly improved spleen volume reduction and symptom relief in myelofibrosis patients compared to ruxolitinib alone, offering a promising new treatment option. Long-term use of gantenerumab may delay Alzheimer's dementia onset in individuals with inherited Alzheimer's, supporting the amyloid hypothesis and paving the way for future prevention strategies. Phase 3 trials demonstrated that povorcitinib, an oral JAK1 inhibitor, significantly improved clinical outcomes in adults with moderate to severe hidradenitis suppurativa, potentially offering a new treatment option. Research linked red meat allergy to bites from additional tick species, expanding the geographic risk area and highlighting the need for clinicians to consider this diagnosis in patients with unexplained allergic symptoms following tick bites.

In this episode, listen to Stephanie L. Graff, MD, FACP, FASCO; and Laura M. Spring, MD, share their clinical insights and takeaways regarding the current treatment landscape for first-line treatment of patients with HER2-positive metastatic breast cancer including:Data from multicenter, single-arm, phase IIIb/IV DESTINY-Breast12 evaluating trastuzumab deruxtecan (T-DXd) in patients with advanced HER2-positive metastatic breast cancer and 2 or fewer previous therapiesTreatment sequencing and preferred treatment options in patients with brain metastasesResults from phase III PATINA trial of trastuzumab, pertuzumab, plus endocrine therapy with or without palbociclib in hormone-receptor positive/HER2-positive metastatic breast cancerThoughts on the use of T-DXd earlier in the treatment paradigm in light of recent results from the PATINA trial and highly anticipated results from the DESTINY-Breast09 trialProgram faculty:Stephanie L. Graff, MD, FACP, FASCODirector of Breast Oncology, Brown University HealthCo-Lead, Breast Cancer Translational Disease Research GroupLegorreta Cancer Center at Brown UniversityAssociate Professor of MedicineWarren Alpert Medical School of Brown UniversityProvidence, Rhode IslandLaura M. Spring, MDBreast Medical OncologistMass General Hospital Cancer CenterHarvard Medical SchoolBoston, Massachusetts Resources:To access the patient cases associated with this podcast discussion, please visit the program page and register for an upcoming webinar on this topic.

To close out this series on prayer, we delve into the raw honesty of Jeremiah's lament in Lamentations 3 and Jesus' anguish in Gethsemane. These biblical accounts reveal that it's okay to struggle with God's will and express our pain to Him. We learn that being godly doesn't mean always feeling okay or having a positive attitude. Instead, true faith allows us to bring our burdens, confusion, and even anger to God. The message emphasizes the difference between isolation and solitude in our spiritual journey. While isolation can be dangerous, solitude with God can be transformative. This teaching encourages us to run to the Father with our problems rather than away from them. Ultimately, we're reminded that God's love is steadfast, His mercies are new every morning, and His faithfulness endures even in our darkest valleys. This message challenges us to be honest in our prayers and to cling to hope, even when we can't feel or see God's presence.

“Primary care physicians are your first line of defense against cancer,” said Matthew Farrell, M.D., an Ohio State Wexner Medical Center primary care physician and a clinical associate professor of family and community medicine. Prevention, screenings and early detection are crucial and begins with a patient's family history with cancer and other medical issues. “We are thorough and ask about their first-degree relatives, their parents, siblings and children, and their secondary relatives, such as grandparents and aunts and uncles,” Farrell said. “If I see a pattern, a certain number of relatives with the same cancer, especially at an early age, there could be a genetic factor.” A patient with an inherited genetic mutation will then be screened at an earlier age and more often. Dr. Farrell also talked about the importance of children receiving the Human Papillomavirus (HPV) vaccine that prevents certain types of cancer. He examines patients to detect skin cancer and melanoma in the early stages. “Skin cancer is the most common form of cancer and it's personal for me; my mother was diagnosed with melanoma three times … and she's doing fine.” Breast cancer and prostate cancer are two of the most common forms of cancer. Dr. Farrell discussed when women should begin getting yearly mammograms, and why and when men should begin to undergo regular Prostate-Specific Antigen (PSA) tests. Men and women without a family history of colorectal cancer should get their first colonoscopy at 45. “My brother-in-law was 52 when he had his first colonoscopy,” Dr. Farrell said. “They found a large tumor in his colon; it was removed, and he's been cancer free for 20 years now.” Lung cancer screenings are relatively new and recommended for long-time smokers. They are vital because “if you wait until there are symptoms it's very hard to treat and cure,” Dr. Farrell said, adding “I'm fortunate to be part of the Ohio State system and the James where we have experts and specialists for every type of cancer and medical issue my patients have.”

On this episode of The Sick Podcast, Pierre McGuire joins Tony Marinaro to discuss the Montreal Canadiens win over the Vancouver Canucks and much more. Later in the show, Tony and Pierre take questions from fans. Learn more about your ad choices. Visit megaphone.fm/adchoices

Cybersecurity and the role of internal audit, an urgent call to action: The forces driving business growth and efficiency contribute to a broad attack surface for cyber assaults. How is the end user protected with good service while not being compromised? First Line includes internet, cloud, mobile, and social technologies, now mainstream, are platforms inherently oriented for sharing. Outsourcing, contracting, and remote workforces are shifting operational control. Second line includes information and technology risk management leaders who establish governance and oversight, monitor security operations, and take-action as needed, often under the direction of the chief information security officer (CISO) Third line of cyber defense—independent review of security measures and performance by the internal audit function. Internal audit should play an integral role in assessing and identifying opportunities to strengthen enterprise security. At the same time, internal audit has a duty to inform the audit committee and board of directors that the controls for which they are responsible are in place and functioning correctly, a growing concern across boardrooms as directors face potential legal and financial liabilities.  

In this First Line episode of the Pro Hockey News Podcast, Adam, Lonny and Richard talk about the buyers and sellers a week out of the NHL Trade Deadline and critique the 4 Nations Quarter Century Teams. The episode is capped off with the #PHNPicks of the week. Follow us on on Bluesky @PHNPodcast.Thanks to our sponsors:My Custom Sports Chair Enter code PHN15 for 15% off your purchaseManscaped save 20% on your purchase going to manscaped.com/prohockeynewsLDE Affinity JewelryFoCo

We often focus on addressing problems after they've occurred in the nonprofit and social sector, but what if we could intervene earlier?After 30 years of research in prevention science, the evidence is clear: many behavioral health issues and related challenges can be prevented.I'm joined by Mitchell Moore, an advanced certified prevention specialist, to discuss the power of early intervention in preventing behavioral health problems—specifically in the context of youth and families.(01:02) Why Mitchell believes funding should shift from reactive solutions like treatment and incarceration to proactive prevention.Skip Ahead:(04:44)  The role of data in helping Prevention Training Services reach out and train so many people.(07:57) What a 9-month community assessment revealed and how it shifted their prevention strategy.(16:45) How media literacy, a key aspect of prevention work, has made him hyper-aware of product placement in movies and commercials.Connect with Mitchell Moore and learn more about Prevention Training Services.Read the full show notes HERE.

Meet Rickard Rakell, first-line former snub! Hear award-winning columnist Dejan Kovacevic's Daily Shots of Steelers, Penguins and Pirates -- three separate podcasts -- every weekday morning on the DK Pittsburgh Sports podcasting network, available on all platforms: https://linktr.ee/dkpghsports Learn more about your ad choices. Visit megaphone.fm/adchoices

#OKINAWA: Observations re the Okinawa chain of islands, also known as the Ryuku chain, the serves as the first line of defense against a PLA attack on Taiwan. Grant Newsham, author, "When China Attacks." https://japan-forward.com/okinawa-its-still-important-and-often-misunderstood/1945 Okinawa Bailey Bridge constructed after the concrete bridge was destroyed in the Battle of Okinawa.