Parallax by Ankur Kalra

In this essential episode of Parallax, Dr Ankur Kalra is joined by Dr Michelle O'Donoghue, cardiologist at Brigham and Women's Hospital and co-author of the recently updated AHA/ACC acute coronary syndrome guidelines. Together, they explore the revolutionary changes reshaping ACS management in 2025. Dr O'Donoghue shares insights from the landmark guideline development process that unified non-ST elevation ACS and ST elevation MI recommendations into a single comprehensive document. The conversation covers game-changing updates including new risk stratification approaches, the shift toward selective invasive strategies, and the introduction of bivalirudin as an alternative anticoagulation option. The discussion highlights the groundbreaking "lower is better" approach to LDL management with new targets below 55 mg/dL, evolving antiplatelet therapy strategies, and the emerging role of ticagrelor monotherapy. Dr O'Donoghue also addresses future directions in cardiovascular care, from GLP-1 agonists to mechanical circulatory support devices, emphasizing how these guidelines represent a fundamental shift toward more personalized, evidence-based ACS management. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

In this profound episode of Parallax, Dr Ankur Kalra welcomes Dr Pam Taub, Professor of Medicine and Director of Preventive Cardiology at UC San Diego, for an enlightening conversation about integrating spirituality, purpose, and scientific curiosity in cardiovascular practice. Dr Taub shares her unique philosophical foundation, shaped by exposure to diverse religions in South India. This experience fostered her belief that all faiths fundamentally center on being a good person and serving others. She explores how this spiritual perspective transforms medicine from a profession into a sacred calling, where patient interactions become profound privileges that fuel her desire to make meaningful impact beyond individual achievements. The episode highlights Dr Taub's groundbreaking work with POTS (Postural Orthostatic Tachycardia Syndrome), demonstrating how scientific curiosity serves as a spiritual path. Her research journey—from recognizing misdiagnosed conditions to conducting the first clinical trial for ivabradine in POTS—exemplifies how deeper questioning and evidence-based inquiry can transform patient lives on a broader scale. The episode also explores Dr Taub's research on time-restricted eating, connecting modern scientific evidence to fasting practices across many faiths. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

In this insightful episode of Parallax, Dr Ankur Kalra is joined by Dr Leslie Saxon, a professor of medicine at Keck School of Medicine USC and executive director for the USC Center for Body Computing. Together, they explore the potential network data have in transforming healthcare delivery and patient survival. Beginning with the origin and aim of the USC Center for Body Computing, the episode dives into the benefits of a network of connected implantable devices to engage patients in their own care. Dr Saxon also shares her vision of overseeing "life care” as well as "sick care" by collecting data on the mind and body, providing insights into her work with professional athletes and the military to understand how the body functions as a system. The discussion later turns to the evolution of computing devices and how we are moving past the concept of "wearables" with AI-centric devices designed specifically for continuous health monitoring.

In this inspiring episode of Parallax, Dr Ankur Kalra engages with Dr Srihari S. Naidu, current President of the Society for Cardiovascular Angiography and Interventions (SCAI) and tenured professor at New York Medical College. Their conversation explores Dr Naidu's compelling journey from his formative years and family influences to his strategic vision for elevating interventional cardiology's national profile. Dr Naidu shares his innovative "LINK" philosophy—Leadership, Innovation, Networking, and Knowledge—which has guided his approach to medicine and leadership. The discussion delves into SCAI's remarkable growth in education, publications, and advocacy under his stewardship, while addressing the critical need to increase public understanding of interventional cardiologists' life-saving contributions to healthcare. The conversation offers valuable insights on career progression in medicine, exploring the delicate balance between knowledge and wisdom across different career stages. Dr Naidu provides thoughtful perspectives on the "sweet spot" of mid-career practice, the importance of cross-generational learning, and SCAI's commitment to fostering diversity by removing barriers for women and underrepresented groups in the field. Essential listening for cardiologists at all career stages, healthcare leaders, and those interested in the evolving landscape of interventional cardiology and its impact on patient care and public health. Buy the SCAI Cap here. (https://shop.scai.org/) Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

In this compelling episode of Parallax, Dr Ankur Kalra explores South Asian cardiovascular health with preventive cardiology experts, Dr Jaideep Patel from Johns Hopkins, and Dr Romit Bhattacharya from Massachusetts General Hospital. The conversation begins with both specialists sharing personal motivations behind their focus on South Asian heart health, from family losses to scientific curiosity about potential genetic and metabolic distinctions. They examine whether South Asians truly face different cardiovascular risks - discussing observations of earlier disease onset, unique lipid patterns, and metabolic dysfunction at lower BMIs - while emphasizing that fundamental prevention strategies remain effective across populations. The episode culminates with powerful closing insights on prevention as an investment—how small, consistent lifestyle modifications can prevent cardiovascular disease onset even in those with genetic predispositions, ultimately enabling fuller, more functional lives in later years. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO

In this illuminating episode of Parallax, Dr Ankur Kalra engages with Dr Jonathan Drezner, Director of Sports Cardiology at the University of Washington, who explores the complex world of cardiovascular risk in competitive athletes. Dr Drezner traces the evolution of sports cardiology from watershed moments involving high-profile athletes like Hank Gathers and Reggie Lewis to today's sophisticated screening protocols. The conversation reveals startling statistics about sudden cardiac death—particularly among specific athlete populations where risks are significantly higher than previously thought. The discussion delves into the limitations of traditional screening questionnaires versus the enhanced detection capabilities of ECG testing, highlighting how proper interpretation has dramatically reduced false positives. Dr Drezner articulates the shift from universal disqualification to personalized risk assessment for athletes with cardiac conditions, emphasizing the critical elements of effective emergency action plans that can mean the difference between life and death on the playing field. Listeners will gain valuable insights into both common and rare cardiac conditions affecting athletes, from hypertrophic cardiomyopathy to anomalous coronary arteries, while understanding the three pillars of modern sports cardiology: epidemiology, screening, and management. This episode offers essential knowledge for cardiologists, sports medicine physicians, and other healthcare professionals involved in athlete cardiac care. Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts: https://www.radcliffecardiology.com/news/parallax-podcast-ankur-kalra-recognised-among-top-medical-podcasts?language_content_entity=en

In this episode of Parallax, host Dr Ankur Kalra sits down with Dr Ambarish Pandey to explore the transformative role of GLP-1 receptor agonists in cardiovascular medicine. Beyond their well-known effects on weight management, Dr Pandey reveals how these "blockbuster drugs" are fundamentally reshaping cardiovascular disease prevention and treatment, with compelling evidence from the landmark SELECT trial. The discussion navigates through real-world clinical scenarios where GLP-1s deliver significant cardiovascular benefits, from post-acute coronary events to established atherosclerotic disease. Dr Pandey provides nuanced, evidence-based recommendations for GLP-1 therapy across various heart failure phenotypes, while addressing common comorbidities like atrial fibrillation and obstructive sleep apnea. Recognizing practical challenges, the conversation offers actionable strategies for medication initiation, dose optimization, and navigating insurance hurdles. The episode concludes with an exciting look toward emerging frontiers, including GLP-1 benefits in chronic kidney disease and innovative metabolic accelerators that could complement existing therapies. For clinicians seeking to optimize cardio-metabolic care in 2025, this discussion provides essential insights into both current best practices and promising therapeutic horizons. Disclosures: Dr Ambarish Pandey is a consultant for Novo Nordisk, Eli Lilly, Roche, and Rivus Pharma. Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts: https://www.radcliffecardiology.com/news/parallax-podcast-ankur-kalra-recognised-among-top-medical-podcasts?language_content_entity=en

Join Dr Ankur Kalra on Parallax as he explores the evolving landscape of precision medicine in cardiology with Dr Calum MacCrae, Vice Chair for Scientific Innovation at Brigham and Women's Heart and Vascular Center. Dr MacCrae reflects on how the promise of matching treatments to individual risk and disease mechanisms has evolved, from its roots in molecular medicine to today's data-driven aspirations, revealing why progress has lagged behind expectations. The discussion dissects the complexities of modern cardiology, challenging assumptions about therapeutic precision by examining barriers like incomplete disease understanding, flawed electronic health records, and the high cost of integrating biomarkers into practice. Listeners will value Dr MacCrae's incisive breakdown of precision medicine's ecosystem, and how innovations at each level could redefine treatment strategies. The episode delivers practical insights for clinicians, while posing critical questions about how systemic inertia and fragmented healthcare delivery can impede meaningful change.

This week's edition of Parallax features an illuminating conversation between host, Dr Ankur Kalra, and Dr Clif Knight. From practicing family physician to passionate advocate for systemic change, Dr Knight's remarkable career journey provides a unique lens through which to examine physician well-being in contemporary healthcare environments. Dr Knight shares how his early observations of colleagues struggling without adequate support systems sparked his dedication to addressing the fundamental inefficiencies and structural barriers undermining physician resilience. The discussion examines how the healthcare landscape has evolved over generations, challenging simplistic narratives about millennial physicians' susceptibility to burnout by contextualizing how documentation burdens, technological implementations, and regulatory frameworks have created unprecedented complexity. Listeners will appreciate Dr Knight's nuanced analysis of the physician ecosystem's five distinct levels and how interventions at each stage—from organizational leadership priorities to individual behavioural practices—can meaningfully enhance well-being. The episode offers actionable insights for healthcare professionals seeking to recalibrate their relationship with medical practice, while also raising important questions about how commercial influences in healthcare delivery may affect both physician autonomy and patient care. For anyone interested in sustainable healthcare systems that support both practitioners and patients, this discussion provides essential perspective on rebuilding resilience at personal and institutional levels. Resources: Action Collaborative on Clinician Well-Being and Resilience, National Academy of Medicine (https://nam.edu/our-work/programs/clinician-resilience-and-well-being/) Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being, National Academy of Medicine (https://nap.nationalacademies.org/catalog/25521/taking-action-against-clinician-burnout-a-systems-approach-to-professional) Joy in Medicine™ Health System Recognition Program, AMA ASSN (https://www.ama-assn.org/practice-management/physician-health/joy-medicine-health-system-recognition-program)

In this thought-provoking episode of Parallax, Dr Ankur Kalra explores the unexpected intersection of cardiology and popular culture with Dr Kristen Shaw and Dr Kevin Harris from the Minneapolis Heart Institute. Their conversation centers around their recently published systematic analysis, "Portrayal of Acute Myocardial Infarction in Popular Film: A Review of Gender, Race, and Ethnicity". Through examination of 100 popular films, our guests unpack striking statistics: 90% of on-screen heart attacks occur in men, and symptom presentation is dramatically overplayed compared to clinical reality. The conversation delves into how these media portrayals potentially shape both patient behavior and public health outcomes, particularly for underrepresented populations. From exploring the stark disconnect between cinematic drama and clinical presentation to discussing practical solutions for improving public health messaging, this episode offers crucial insights for healthcare providers working to bridge the gap between media perception and medical reality. The discussion extends into broader themes of healthcare mistrust in the post-pandemic era, offering valuable perspectives on how improved representation could enhance patient education and emergency response outcomes. Essential listening for cardiologists, healthcare educators, and anyone interested in how media shapes public understanding of cardiovascular disease.

In this eye-opening episode of Parallax, Dr Ankur Kalra sits down with Dr Stephen Cook to explore groundbreaking research on LGBTQ+ experiences in cardiology. Drawing from Dr Cook's recently published JACC Advances paper "Experiences of Lesbian, Gay, Bisexual, Transgender, and Queer Cardiology Physicians and Fellows in Training", they unpack crucial findings about workplace harassment, professional development, and the evolution of inclusivity in cardiac care. From examining the stark statistics on workplace experiences to discussing the importance of SOGI data collection, this conversation reveals both challenges and opportunities for positive change. Learn how the landscape shifts from medical school to fellowship, why mentorship matters, and what steps the American College of Cardiology is taking to create a more inclusive environment for all cardiac professionals. Whether you're a healthcare professional, trainee, or ally, this episode offers valuable insights into building a more equitable future in cardiology.

The COVID-19 pandemic forced cardiology practices to rapidly evolve - but which changes are here to stay? Join Dr Ankur Kalra in conversation with Dr Edward Fry, former President of the American College of Cardiology, as they explore how the pandemic catalyzed lasting changes in cardiovascular care delivery. From the rapid adoption of telehealth and remote monitoring to the repurposing of CT scan technology, discover how cardiology practices are innovating in response to unprecedented challenges. Dr Fry shares crucial perspectives on pressing issues including the growing workforce shortage amid an aging specialty, the complexities of private equity investment in comprehensive cardiology practices, and the critical need for value-based care solutions in an evolving reimbursement landscape. This episode offers vital insights into rebuilding patient trust through collaborative decision-making and physician advocacy. Dr Fry draws from his leadership experience during this challenging period to outline how cardiologists can actively shape healthcare's future through education, research, and policy engagement - providing an essential roadmap for healthcare leaders navigating the post-pandemic landscape.

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Sukhjinder Nijjer for their much-anticipated annual review of advancements in cardiovascular medicine that defined the year 2024. Dr Nijjer, a Consultant Cardiologist in the UK, serves as the President of the Royal Society of Medicine and is an Honorary Senior Clinical Lecturer at Imperial College London. This episode explores emerging trends in the treatment of valvular heart disease, focussing on TAVI procedures and transcatheter interventions. It also covers recent advancements in pharmacological management for cardiovascular conditions. Drs Kalra and Nijjer share their perspectives and experiences, offering valuable insights, practical tips and considerations when interpreting this year's most impactful trials: EARLY TAVR RESHAPE 2 MATTERHORN TRILUMINATE TOPSPIN FINEARTS-HF What are the most impactful cardiovascular trials of 2024? How do Dr Kalra and Dr Nijjer integrate the latest information into their daily practices?

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Sukhjinder Nijjer for their much-anticipated annual review of advancements in cardiovascular medicine that defined the year 2024. Dr Nijjer, a Consultant Cardiologist in the UK, serves as the President of the Royal Society of Medicine and is an Honorary Senior Clinical Lecturer at Imperial College London. This episode focuses on recent developments in interventional cardiology, covering coronary interventions, new device technologies and challenging patient populations. Drs Kalra and Nijjer share their perspectives and experiences, offering valuable insights, practical tips and considerations when interpreting this year's most impactful trials: REDUCE-AMI PREVENT FAVOR III ORBITA-COSMIC DANGer SHOCK SENIOR-RITA NOTION 3 What are the most impactful cardiovascular trials of 2024? How do Dr Kalra and Dr Nijjer integrate the latest information into their daily practices?

In this compelling episode of Parallax, host Ankur Kalra sits down with Dr Sharonne Hayes, a trailblazing Professor of Cardiovascular Medicine and the vice chair for academic advancement and faculty development at Mayo Clinic. Together, they explore the critical intersections of career flexibility, diversity, and inclusion in modern medicine. Drawing from her extensive experience, Dr Hayes challenges traditional career paradigms in cardiology, offering a nuanced perspective on professional growth that prioritizes personal well-being and systemic change. The conversation delves deep into the complex landscape of medical careers, addressing unconscious biases, workforce equity, and the transformative power of inclusive leadership. Listeners will gain profound insights into strategic career navigation, practical strategies for achieving academic recognition, and the critical importance of health equity in cardiovascular care. Throughout the episode, Dr Hayes provides a masterclass in professional development, sharing her unique approach to career management that balances personal priorities with professional aspirations. From founding the Women's Heart Clinic to her groundbreaking research on academic rankings, she offers a roadmap for cardiologists seeking meaningful and flexible career paths. A must-listen for medical professionals, educators, and anyone passionate about creating more equitable and supportive healthcare environments.

In this thought-provoking episode of Parallax, Host, Dr Ankur Kalra engages in an illuminating conversation with Dr Karen Joynt Maddox, a distinguished cardiologist and health policy researcher at Washington University School of Medicine in St. Louis. Together, they navigate the complex intersection of cardiovascular medicine, health economics, and public health policy. Dr Joynt Maddox shares her unique journey into health economics research, offering valuable insights for cardiologists considering this vital career path. The discussion delves deep into the need for enhanced collaboration between clinicians and policymakers, emphasizing how physicians' frontline experiences can inform more effective healthcare policies. In examining the growing presence of private equity in cardiology practices, Dr Joynt Maddox provides nuanced insights into this transformative trend. Through thoughtful analysis, she explores how this financial model shapes healthcare delivery, innovation, and patient outcomes. The conversation extends to broader economic challenges in cardiovascular medicine, particularly the intricate balance between fostering medical innovation and ensuring accessible, affordable care for patients. Drawing from her extensive research experience, Dr Joynt Maddox emphasizes the role of social determinants in cardiovascular health outcomes. The episode concludes with a compelling discussion on integrating public health principles into medical education, offering a vision for a more holistic approach to cardiovascular care.

In this week's episode of Parallax, host Dr Ankur Kalra engages in a thought-provoking discussion with Dr Stephen Smith, a pioneer in electrocardiography and myocardial infarction diagnosis. They delve into the groundbreaking OMI/NOMI paradigm (Occlusion MI vs Non-Occlusion MI), challenging the traditional STEMI vs non-STEMI terminology that has long been the cornerstone of acute coronary syndrome management. Dr Smith presents compelling evidence highlighting the limitations of ST-elevation as a marker for acute coronary occlusion, discussing his recently published review paper: "From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction". The conversation explores the proposed shift to the OMI/NOMI terminology and the specific ECG criteria for diagnosing occlusion MI. Dr Smith discusses the challenges in disseminating this new paradigm and teaching these refined ECG interpretation skills to clinicians. Dr Kalra and Dr Smith explore exciting developments in AI-assisted OMI detection and ongoing studies aimed at validating the OMI/NOMI approach. How can clinicians effectively implement the OMI/NOMI criteria into daily practice? What challenges exist in teaching these new ECG interpretation skills, and how can they be overcome? What advice does Dr Smith have for our listeners? Full source library for this episode can be found on radcliffecardiology.com.

This week on Parallax, Dr Ankur Kalra welcomes Dr Brooke Aggarwal to dive deep into the fascinating intersection of behavioural science and nutrition education. Dr Brooke Aggarwal, an Assistant Professor at Columbia University Medical Center, focuses her research on how behavioural and psychological factors influence adherence to cardiovascular disease prevention guidelines. In this episode, Dr Aggarwal shares insights from her groundbreaking Family Intervention Trial for Heart Health (FIT Heart) study, unveiling the crucial role of social support and caregiver dynamics in maintaining healthy behaviours. Dr Kalra and Dr Aggarwal discuss innovative techniques such as motivational interviewing and cognitive behavioural therapy that are transforming the landscape of nutrition counselling. Dr Aggarwal shares her insights into the practical applications of behavioural science in clinical settings, emphasising the importance of addressing cognitive distortions with evidence-based approaches. The discussion highlights the need for healthcare providers to adapt their language to enhance accessibility, creating a supportive environment for sustainable lifestyle changes within patients. Join us as we explore how combining behavioural science with nutrition knowledge can empower individuals to take control of their health and create meaningful, sustainable improvements in their lives.

In this episode of Parallax, Dr Ankur Kalra reunites with Dr Purvi Parwani for a deep dive into the groundbreaking data unveiled at ESC Congress 2024. Dr Parwani, Director of the Women's Cardiovascular Disease Clinic and a leading expert in her field, serves as Associate Professor of Medicine and Director of the Echocardiography Laboratory for Advanced Cardiovascular Imaging at Loma Linda University Health. Dr Parwani offers a comprehensive analysis of the most impactful trials presented at the congress. She delves beyond the headlines, exploring the practical implications these findings hold for the future of patient care. Dr Kalra and Dr Parwani engage in a stimulating discussion, comparing the new data to prior research and exploring how these insights can be translated into real-world improvements for our patients. Key Trials included: MATTERHORN: Transcatheter versus surgical mitral valve repair in patients with heart failure and secondary mitral regurgitation (NCT02371512) RESHAPE-HF2: Percutaneous repair of moderate-to-severe or severe functional mitral regurgitation in patients with symptomatic heart failure (NCT02444338) TRI FR: Multicentric randomised evaluation of the transcatheter edge-to-edge repair in the treatment of severe isolated secondary tricuspid regurgitation (NCT04646811) RHEIA: Transcatheter versus surgical aortic valve replacement in women with severe aortic stenosis (NCT04160130) SENIOR RITA: Older patients with non-ST segment elevation myocardial infarction randomised interventional treatment trial

In this week's episode, Dr Ankur Kalra welcomes authors Dr Srihari Naidu and Lindsay Davis to discuss their newly published children's book, Lindsay's Big Heart. A leading interventional cardiologist, Dr Naidu, and patient advocate, Ms Davis, have collaborated to bring the complex heart condition hypertrophic cardiomyopathy (HCM) to life for young readers. Lindsay Davis shares her personal journey with HCM, offering a firsthand perspective on the challenges and triumphs of living with the condition. Dr Srihari Naidu discusses the importance of translating complex medical information into a format that children can understand and appreciate. As a parent himself, he was inspired to create a resource that would help families navigate the complexities of HCM. The authors share the challenges and rewards of bringing Lindsay's Big Heart to publication, from securing a publisher to finalising the illustrations. They believe that the book can help children feel more informed and empowered, reducing fear and anxiety associated with HCM. Additionally, they hope the book will raise awareness of the condition and encourage early diagnosis and treatment. Join us as we delve into the inspiration behind the book, the writing process, and the importance of accurate and engaging medical education for children.

This week on Parallax, Dr Ankur Kalra welcomes Dr Marc Gerdisch to discuss a groundbreaking study on reducing opioid use after cardiac surgery. Dr Marc Gerdisch is the Chief of Cardiovascular and Thoracic Surgery and Co-Director of the Heart Valve Center and Atrial Fibrillation Program at Franciscan St. Francis Health. He is a senior partner at Cardiac Surgery Associates and a Clinical Assistant Professor of Thoracic and Cardiovascular Surgery at Loyola University Medical Center in Chicago. Dr Gerdisch shares insights into his research on rigid sternal fixation and enhanced recovery protocols, which have shown promising results in postoperative pain management and patient recovery. In this episode, Dr Kalra and Dr Gerdisch discuss the specifics of the study, including the four-cohort design and the steps taken to expedite opioid-free recovery. Dr Gerdisch also shares valuable advice on overcoming physician inertia and building a strong case for implementing such a programme, including cost-benefit analysis considerations. What motivated the study? How can a holistic approach to cardiac surgery recovery be implemented? What advice does Dr Gerdisch have for our listeners? Sources: Gerdisch MW, et al. Ann Thorax Surg 2024. Rigid Sternal Fixation and Enhanced Recovery for Opioid-Free Analgesia After Cardiac Surgery. DOI: 10.1016/j.athoracsur.2024.06.032 CE Cox. TCTMD 2024. Holistic Approach to Cardiac Surgery Can Sharply Cut Opioid Use. Available at: https://www.tctmd.com/news/holistic-approach-cardiac-surgery-can-sharply-cut-opioid-use. Accessed August 12, 2024.

In this enlightening episode of Parallax, which focuses on guideline directed medical therapy (GDMT), Dr Ankur Kalra is joined by two guests, Dr Georges Chahoud, a Heart Failure Cardiologist at St. Louis Cardiology Consultants in the US, and Dr Carsten Israel, Chief of Cardiology at Bethel-Clinic in Germany. Building on their expertise, they share insights on how they would personally consult colleagues on how to manage patients with new onset acute decompensated heart failure (ADHF) and how to optimise this management in the hospital setting. They cover key topics such as why early initiation of GDMT even before hospital discharge is important, what other imaging modalities can help in better stratifying patients at risk of sudden cardiac death and they address the management and assessment of the risk for sudden cardiac death in patients on quadruple backbone GDMT. This episode is a must-listen for all healthcare professionals dedicated to advancing their understanding and treatment of heart failure. This series is supported by ZOLL and is intended for Health Care Professionals.

In this compelling episode of the Parallax Podcast, host Dr Ankur Kalra sits down with Dr Janarthanan Sathananthan, an interventional and structural cardiologist and the Chief Medical Officer of Interventional Cardiology at Boston Scientific. Dr Sathananthan recounts his life's journey, from being born in Sri Lanka during the civil war, and moving to Zimbabwe, New Zealand, Canada, and finally North America. He shares how his diverse upbringing profoundly shaped his career in cardiology. Together, Dr Kalra and Dr Sathananthan delve into cultural challenges and lessons learned from Dr Sathananthan's father, a dentist who experienced significant discrimination throughout his career. They explore Dr Sathananthan's decision to pursue interventional cardiology, and his passion for the intersection of technology and medicine. This episode also delves into Dr Sathananthan's role as Chief Medical Officer at Boston Scientific, focusing on global initiatives to expand coronary therapies and the growth of PCI in the Asia-Pacific region. They also touch on the ongoing struggle to balance work and personal life in a demanding field. Listeners are invited to submit questions and comments to podcast@radcliffe-group.com, which may be addressed by Dr Kalra in the next episode. Join us for this insightful conversation with Dr Janarthanan Sathananthan on the Parallax Podcast. Guest: @J_Sathananthan Host: @AnkurKalraMD Produced by: @RadcliffeCARDIO

In this week's Parallax, Dr Ankur Kalra welcomes back Shelley Wood, best known for her work in the cardiology community as the editor-in-chief of TCTMD and Editorial Director of CFR. They discuss her work as a creative author and her second novel, "The Leap Year Gene," set to be published by Harper Collins in Canada and Union Square Press in the US in August 2024. Blending the intrigue of a medical thriller with a sweeping overview of the twentieth century, "The Leap Year Gene" tells the story of Kit McKinley, whose rare genetic condition causes her to age one year for every four. In this rich discussion, Ms Wood shares how her extensive experience as a medical writer and editor shaped her approach to crafting the novel. Dr Kalra and Ms Wood also explore one of the book's central themes: eugenics, tracing its historical roots and examining its long shadow on medicine. Ms Wood, who balances a demanding full-time job with her creative writing, shares candid insights into her routine and the challenges of writing and publishing fiction. Tune in for an inspiring conversation about creativity, the human condition, and balancing responsibilities. To pre-order Shelley Wood new novel search for The Leap Year Gene/ The Leap Year Gene of Kit McKinley in your favourite independent bookshop or click here: https://www.amazon.co.uk/Leap-Year-Gene-Novel/dp/1443473162

This week on Parallax, Dr Ankur Kalra welcomes Eric Radtke, Vice President at Worldwide Innovations & Technologies, Inc, and Barbara Breininger, a cardiovascular radiologic technologist and clinical manager with 26 years of experience. This special episode dives deep into the crucial topic of radiation hygiene, exploring it from the perspectives of both manufacturers and users of radiation safety products. Barbara Breininger shares her experiences traveling nationwide to educate healthcare professionals on radiation safety, emphasizing the need for collective awareness and best practices in cath labs. Eric Radtke discusses the company's evolving focus on radiation safety, the origins of their initiatives, and the concerning impacts of radiation exposure as revealed by recent studies. We'll also explore practical steps to enhance safety and delve into the RADPAD tools that can shield interventional cardiologists and allied professionals from exposure. How can we protect ourselves from radiation in the Cath lab? How can we raise awareness of radiation hygiene? Trials mentioned in the episode: Aizer A, Qiu JK, Cheng AV, et al. Utilization of a Radiation Safety Time-Out Reduces Radiation Exposure During Electrophysiology Procedures. JACC EP 2019; 5:5:626-634. https://doi.org/10.1016/j.jacep.2018.12.002 Ahmad IM, Abdalla YM, Moore TA, et al. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. Antioxidants 2019; 8:1. https://doi.org/10.3390/antiox8010012 Support: This episode is supported by Radcliffe Cardiology; it received no funding from Worldwide Innovations & Technologies.

In this week's Parallax, host Dr Ankur Kalra welcomes back Dr Jonathan Fisher, a cardiologist, organizational well-being leader, and bestselling author of Just One Heart: A Cardiologist's Guide to Healing, Health, and Happiness. In this compelling conversation, Dr Fisher shares his personal experience with burnout within the US healthcare system. He provides a concise overview of the roots of Western medicine's culture and the current epidemic of physician burnout and depression. Dr Kalra then invites him to explore solutions for reversing these negative trends and enhancing patient care. Dr Fisher discusses the workshops he leads, emphasizing core principles like positive attitude, compassion, connection, and teamwork. He also offers a sneak peek into his new book that extends the discussion to a wider audience. Tune in for a rich discussion on the future of healthcare, well-being, and rediscovering the human connection at the heart of medicine. Just One Heart: A Cardiologist's Guide to Healing, Health, and Happiness is available to order here: https://www.amazon.com/Just-One-Heart-Cardiologists-Happiness-ebook/dp/B0D1526W7D

Dr Ankur Kalra's guest this week is Dr Saraschandra Vallabhajosyula, Interventional and Critical Care Cardiologist, Assistant Professor of Medicine at the Warren Alpert Medical School of Brown University and the Director of the Cardiac Intensive Care Unit at Rhode Island Hospital, the Miriam Hospital and Lifespan Cardiovascular Institute. In this episode of Parallax, they delve into the latest insights from ACC.24 through the lens of five pivotal late-breaking trials. Dr Vallabhajosyula offers a deep dive into the nuances of each study. Together, Dr Kalra and Dr Vallabhajosyula distil the complexities of these trials into key messages for practice, grounded in their own clinical experiences. In the spotlight are five key trials: 1. DanGer Shock: Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock 2. RELIEVE-HF: Safety and effectiveness of the V-Wave® Ventura® Interatrial Shunt for the treatment of heart failure (HF) 3. PREVENT: Preventive PCI or medical therapy alone for vulnerable atherosclerotic coronary plaque 4. REDUCE AMI: Decreased usage of beta-blockers after acute myocardial infarction 5. ORBITA-COSMIC: Coronary sinus reducer for the treatment of refractory angina Dr Kalra and Dr Vallabhajosyula dissect the practical implications of these trials, answering pressing questions and addressing emerging dilemmas. What are the key takeaways from ACC.24? How do these findings shape contemporary clinical practice?

In this week's episode of Parallax, Dr Ankur Kalra welcomes Dr Shashank Sinha. Dr Sinha is an Advanced Heart Failure, Mechanical Circulatory Support, and Transplant Cardiologist at Inova Fairfax Medical Campus, where he serves as Co-Medical Director of the Cardiac Intensive Care Unit and Director of the Cardiovascular Critical Care Research Program. Additionally, he holds the position of Assistant Professor of Medical Education at the University of Virginia School of Medicine. In this episode, Dr Sinha shares his insights on leadership after participating in the prestigious Presidential Leadership Scholars Programme. This programme, designed for mid-career professionals with 10+ years of experience, aims to foster bipartisan, action-oriented leaders. Dr Sinha discusses what motivated him to apply for the programme and guides us through the practical details of the process. Ankur asks him about his modules and the lessons he derived from this multidisciplinary programme. Dr Sinha and Dr Kalra discuss civic duty and the values that can be nurtured to make a difference on a larger scale. Dr Kalra also asks about Dr Sinha's approach to conflict management and combating inherent bias. What is the Presidential Leadership Programme? What qualities constitute a good leader? How can individuals foster their leadership skills?

In this informative episode of Parallax, Dr Ankur Kalra is joined by Dr Andrew Darlington, an Advanced Heart Failure Cardiologist at Piedmont Heart Institute in Georgia. Together, Dr Kalra and Dr Darlington delve into the significance of assessing volume status in patients with heart failure, highlighting its continued relevance in 2024 despite the availability of other diagnostic tools. They caution that mistakes in evaluating volume status can have significant consequences, potentially resulting in alterations in management and negative outcomes. Dr Kalra asks Dr Darlington about his approach to taking medical history. Dr Darlington shares some of the cues he looks for during a physical exam and the art of assessing neck veins. Together, they explore thoracic impedance, its definition, the technologies available to measure this, including a wearable remote monitor and strategies for effectively communicating this technology to patients with worsening heart failure. Dr Darlington gives a comprehensive overview of the recent clinical data presented at ACC 2023 on the BMAD trial, which aimed to assess the impact of this wearable remote monitor. This series is supported by ZOLL and is intended for Health Care Professionals.

In this week's Parallax episode, Dr Ankur Kalra welcomes Dr Haider Warraich, a cardiologist at Brigham and Women's Hospital. Dr Warraich is not only a Senior Advisor for Chronic Disease to the FDA Commissioner but also a prolific author, having written three books, including "Song of Our Scars: The Untold Story of Pain." He is a regular contributor to publications like the New York Times and the Washington Post. During the conversation, we learn more about Dr Warraich's journey into medicine and his current role at the FDA, along with his passion for writing. Dr Kalra asks about how Dr Warraich manages his busy schedule and what it takes to write a book. Dr Warraich openly shares his personal experience grappling with chronic pain, a pivotal event that not only influenced his career trajectory but also inspired his book "Song of Our Scars." Moreover, he discusses his role as a Senior Advisor to Dr Robert M Califf, offering insights into his day-to-day responsibilities within the FDA. The conversation also touches upon the agency's perspective on emerging technologies like artificial intelligence (AI). How does writing complement Dr Warraich's work as a physician? How did he become a senior advisor to Dr Robert M Califf at the FDA? What is his message to our listeners?

Join Dr Ankur Kalra on Parallax this week as he welcomes Dr Candice K Silversides, the first Editor-in-Chief of JACC: Advances. Dr Silversides, a cardiologist and professor at the University of Toronto, wears many hats. She leads the Obstetric Medicine program and directs the Cardio-Obstetric clinic at Mount Sinai Hospital, while simultaneously steering JACC: Advances in its exciting early stages. Dive into the unique synergy between her clinical practice and editorial leadership as Dr Silversides shares her vision for the journal. Learn how she navigates diverse responsibilities, manages peer reviews, and ensures fair evaluation of the submitted manuscripts. Get insights into launching a journal, from adapting to the needs of the readership and editorial board selection to time management. Dr Silversides joins Dr Kalra in exploring the evolving landscape of academic publishing, discussing the challenges and opportunities presented by AI and other advancements. What does the future of academic publishing look like? What is the role of AI? What are the day-to-day tasks of an Editor-in-chief?

In the season 6 premiere of Parallax, Dr Ankur Kalra welcomes Dr Alex Carter, a Senior Lecturer at the London School of Economics and Political Science (LSE) Department of Health Policy. As the course director for the executive MSc in Health Economics, Policy & Management, Dr Carter delves into the origins and evolution of LSE's health economics program, showcasing its transformation in response to the challenges facing health systems in 2024. The podcast embarks on an exploration of the program's three fundamental pillars: health economics, outcomes measurement, and management. Dr. Carter underscores the importance of efficiently allocating scarce resources, evaluating health system performance through population outcomes, and translating theoretical knowledge into practical application through leadership. Dr Kalra asks Dr Cater about his work with the HyperMarker project, an EU-funded initiative that leverages big data analytics to optimize the prescription of antihypertensives and generate personalized treatment recommendations for patients with hypertension. What do we gain by understanding health economics? How was one of the first health economics programs created? What is Dr Carter's message to our listeners?

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Sukhjinder Nijjer for their much-anticipated annual review of advancements in cardiovascular medicine that defined the year 2023. Dr Nijjer, a Consultant Cardiologist in the UK, serves as the President of the Royal Society of Medicine and is an Honorary Senior Clinical Lecturer at Imperial College London. Drs Kalra and Nijjer share their perspectives and experiences, offering valuable insights, practical tips and considerations when interpreting this year's most impactful trials: • ORBITA-2 (AHA Scientific Sessions): PCI for stable angina • FIRE (ESC Congress): Functional versus culprit-only revascularization in elderly patients with myocardial infarction and multivessel disease • DAPA-MI (AHA Scientific Sessions): SGLT2i in MI without diabetes or heart failure • ILUMIEN IV (ESC Congress): OCT vs angiography-guided PCI • OCTOBER (ESC Congress): OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions • ARTESIA (ESC Congress): Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation • SELECT (AHA Scientific Sessions): Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes What are the most impactful cardiovascular trials of 2023? How do Dr Kalra and Dr Nijjer integrate the latest information into their daily practices?

In this thought-provoking episode, Dr Ankur Kalra is joined by Dr Anuradha Lala, assistant professor of medicine at the Zena and Michael A Wiener Cardiovascular Institute and in the Department of Population Health Science and Statistics at Icahn School of Mount Sinai and Mount Sinai Hospital. Dr Lala is also the Deputy Editor of the Journal of Cardiac Failure. Dr Kalra and Dr Lala delve into the critical topic of disparities in care within the healthcare system from a cardiologist's point of view and explore actionable steps towards a more inclusive and fair healthcare landscape. Dr Lala advocates for an approach focused on the patient, valuing the unique needs and preferences of each individual as crucial elements in creating a personalised treatment strategy. In this podcast, she provides insight to her study on 'Acute Heart Failure Presentation to the Emergency Department: National Trends by Race and Ethnicity 2007-2019*' and how it shows there are differences based on race and ethnicity in terms of wait time and the demographic of patients presenting. The fundamental principle that healthcare is a basic human right is emphasised, setting the stage for a deeper exploration of the disparities prevalent within the system. Through candid discussions, the episode highlights the differences in healthcare access and quality and examines methods to prevent and mitigate these discrepancies. Addressing the 'why' behind these disparities is a central theme, exploring the presence of subconscious biases within healthcare. The conversation isn't just theoretical, Dr Kalra and Dr Lala present real-life scenarios and personal stories, offering a refreshingly honest and open perspective. Key questions are explored, such as identifying the top places where disparities in care exist and strategies to address these issues. This series is supported by ZOLL and is intended for Health Care Professionals.

On October 28th, 2023, the Canadian Cardiovascular Society (CCS) released a new classification system for acute atherothrombotic myocardial infarction (MI) based on stages of tissue injury severity (CCS-AMI). This expert consensus is the result of decades of data on acute MI with reperfusion therapy. Dr Ankur Kalra is joined this week on Parallax by Dr Andreas Kumar, Chairperson of the Writing Group of the Expert Consensus Statement, Associate Professor of Medicine at the Northern Ontario School of Medicine, Cardiologist at Health Sciences North, and President of the Canadian Society of Cardiovascular MRI. In this informative episode, Dr Kumar shares what led his team and the CCS to introduce a new classification scheme for acute MI. He discusses how research from the past 15 years highlighted the need to incorporate tissue changes resulting from acute myocardial infarction (MI) into clinical practice. Dr Kumar outlines the four stages of CCS-AMI, and we gain insight into how this novel classification scheme could impact bedside medicine. Dr Kalra asks about treatment optimization based on stages of tissue injury severity. Dr Kumar delves into the risks associated with the four stages, with a particular focus on CCS Stage 4, MI with reperfusion haemorrhage. Finally, Dr Kumar highlights how the use of the classification system can lay the foundation for future research studies and bring us closer to finding answers and identifying agents suitable for different stages of acute MI. What are the key messages from CCS-AMI? What are the data behind the new scheme? How might the new classification scheme impact the development of new treatment options? Resources: Kumar A, et al. The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement. CJC 2023. https://doi.org/10.1016/j.cjca.2023.09.020 Gaba P & Bhatt DL. Promise of a Novel Classification System for Acute Myocardial Infarction. CJC 202. https://doi.org/10.1016/j.cjca.2023.10.011 Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: @AndreasKumarMD Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In this week's episode of Parallax, Dr Ankur Kalra's guest is Dr Craig R Smith, Cardiac Surgeon and Chairman of the Department of Surgery at Columbia Presbyterian Hospital. In 2020, The Wall Street Journal called Dr Smith the pandemic's most powerful writer. Each day throughout the COVID-19 crisis, Dr Smith provided the faculty and staff with updates on pandemic response and priorities, offering both vital information and unwavering support. This month, Dr Smith released his book, 'Nobility in Small Things: A Surgeon's Path'. In this inspiring episode, Dr Smith delves into the story behind his book and the motivating circumstances that led him to become an author. Dr Kalra asks Dr Smith about his experience as a leader during the pandemic as a surgeon. Dr Smith shares the story of his unconventional journey into medicine, emphasizing how hard physical labor built his resilience and prepared him for his residency. Dr Kalra also asks about Dr Smith's experience as a surgeon for President Bill Clinton in 2004. We learn more about some of the highlights of Dr Smith's book and his advice for listeners aspiring to become writers. Nobility in Small Things is available for purchase here: https://us.macmillan.com/books/9781250278531/nobilityinsmallthings Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: Dr Craig R SmithHost: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In this week's episode of Parallax, Dr. Ankur Kalra welcomes Dr. John Mandrola, a cardiac electrophysiologist practicing in Louisville and the host of the popular podcast "This Week in Cardiology" and co-author of Sensible Medicine, among other forums. In this insightful episode, we delve into Dr. Mandrola's career journey. He discusses how the beginnings of his career during a period of significant innovations and the reversal of expert opinions profoundly influenced his perspective on medicine, leading to a more conservative stance. Dr. Kalra then invites Dr. Mandrola to share the motivations that drive his work as a medical journalist and communicator, along with his methods of selecting studies to highlight in his writings and show. Dr. Mandrola emphasizes the importance of bedside medicine and the critical role of translating and interpreting evidence in modern healthcare. Together, Dr. Kalra and Dr. Mandrola explore the complexities of practicing medicine today and ponder the value propositions associated with the latest innovations. Dr. Mandrola sheds light on what he considers the most promising new advances in the field. He concludes the episode by offering valuable advice to our listeners, advocating for the implementation of innovations grounded in medical evidence and supported by sound policies. Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: @drjohnm Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In the landmark centennial episode of Parallax, Dr Ankur Kalra welcomes a true luminary in the field of cardiology, Dr Valentin Fuster. Dr Valentin Fuster, a renowned cardiologist, currently holds multiple roles. He serves as the Director of the Cardiovascular Institute and as the Physician-in-Chief at the Mount Sinai Medical Center in New York. Additionally, Dr Fuster is the General Director of the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid. Notably, he also holds the position of Editor-in-Chief at the Journal of the American College of Cardiology (JACC). In this candid and rich episode, Dr Fuster delves into his upbringing in Barcelona and reflects on the influential role his family played in providing him with role models and a sense of freedom during his formative years. Dr Fuster invites us to contemplate the concepts of mentorship and trust by recounting pivotal moments from his life, revealing how these principles propelled him towards a life of fulfilment. Dr Kalra and Dr Fuster revisit one of the central questions explored in Dr Fuster's book, "The Circle of Motivation" – how can one maintain a positive outlook and prepare for life's inevitable fluctuations? Dr Fuster shares insights into his daily routine, which aids him in reflection, tuning into his intuition, and making choices that align with his true self. While discussing his priorities, we gain insight into Dr Fuster's projects, driven by the concern that we do not intervene early enough in the treatment of individuals. Dr Kalra and Dr Fuster engage in a discussion about Dr Fuster's thoughts on JACC and Dr Fuster outlines the key principles of leadership in various contexts, accompanied by examples from his own life. Dr Kalra seeks Dr Fuster's perspective on augmentative intelligence and the future of medicine, shedding light on what Dr Fuster believes is essential for contemporary medical education in light of the transformative impact of AI. Finally, Dr Fuster shares three influential books that have shaped his thinking, along with a message for our listeners. Resources: JACC Journals' Pathway Forward With AI Tools: The Future Is Now https://www.jacc.org/doi/10.1016/j.jacc.2023.02.030 The Circle of Motivation https://www.amazon.com/Circle-Motivation-Valentin-Fuster-ebook/dp/B07YLVMSKH

In this week's Parallax, Dr Ankur Kalra's guest is Dr Mirvat Alasnag. Dr Alasnag is an interventional cardiologist at King Fahad Armed Forces Hospital (KFAFH) in Saudi Arabia. Additionally, she serves as the Editor-in-Chief at Current Cardiovascular Imaging Reports and is a member of the Board of Trustees at SCAI. Dr Alasnag and Dr Kalra provide a comprehensive review of the key highlights from ESC Congress 2023. Dr Alasnag distills the background and latest evidence from key interventional trials, emphasizing their significance for patient care. Tune in to discover the strategies that Dr Kalra and Dr Alasnag are currently employing and gain insights into how these data will shape their future decision-making in the catheterization laboratory. Don't miss this informative discussion at the forefront of interventional cardiology. Trials included: FIRE: Physiology-Guided Complete PCI in Older MI Patients MULTISTARS AMI: MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction ILUMIEN IV: Optical coherence tomography-guided coronary stent implantation compared to angiography OCTOBER: European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction OCT Vs IVUS Vs Angiography Guidance OCTIVUS: Optical coherence tomography non-inferior to intravascular ultrasound for stent guidance What are the take-home messages from ESC 2023 for interventional cardiologists? How can we interpret the results for patient care? What new data have the power to change guidelines? Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guests: @mirvatalasnag Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Jag Singh to discuss Dr Singh's recently published book, "Future Care," which delves into the exciting evolution of medicine over the next 5 to 10 years. Dr Jagmeet Singh is a Cardiac Electrophysiologist and a Professor of Medicine at Harvard Medical School. He is also the Founding Director of the Resynchronization and Advanced Cardiac Therapeutics Program at Massachusetts General Hospital. "Future Care" wasn't written overnight; it had been simmering in Dr Singh's mind for nearly a decade. The catalyst for this book was a convergence of factors, including the COVID-19 pandemic and Dr Singh's personal health journey. Drawing from his experiences across three different countries, his role in patient care and leadership and his unique perspective as a patient himself, Dr Singh explores the crucial question of how medicine can and should evolve. In this episode, Dr Kalra and Dr Singh delve deeply into the ideation, research, and writing process that brought "Future Care" to life. We learn more about Dr Singh's valuable tips for aspiring authors. Dr Singh unpacks the four key chapters of his book: Sensors, Virtual Care, AI, and the Establishment of a sustainable healthcare system. Looking into the future, Dr Singh paints a vivid picture of the hospital of tomorrow—a place where technology and human touch harmoniously converge. As we adapt to the changes brought about by the pandemic, Dr Singh outlines the necessary steps to foster a reality in which we can utilize these technologies to create more time for human connection. What advice does Dr. Singh have for our listeners? What does the future of medicine look like? How can we scale high-tech solutions effectively? Order Dr Singh's book today: https://mcpress.mayoclinic.org/product/future-care/

In the finale of our series "Conversations about Hypertrophic Cardiomyopathy", Dr Ankur Kalra welcomes, Dr Anjali Tiku Owens, for a dynamic and practical discussion. Dr Owens is Medical Director of the Center for Inherited Cardiac Disease and Associate Professor of Medicine at the Hospital of the University of Pennsylvania. This series is supported by an unrestricted educational grant from Bristol Myers Squibb. Please see www.camzyosrems.com for important safety information. In this week's episode, Dr Kalra and Dr Owens take us on a journey through the complexities of hypertrophic cardiomyopathy (HCM), with focus on the diagnostic challenges and breakthroughs in this field. Emphasising with the critical importance of making accurate diagnoses, Dr Owens shares her insights into identifying the common mimickers of HCM through a structured approach starting with taking the patients history. As the conversation delves deeper, Dr Owens discusses the various diagnostic tools and tests used to rule out other conditions and uncover the underlying aetiology. She navigates us through the algorithm for interpreting genetic test results, differentiating pathogenic variants, benign variants and variants of uncertain significance (VUS). Dr Owens talks about the wider implications for family members and the cases in which she recommends screening. Dr Kalra asks Dr Owens about her approach to exercise in HCM patients. Additionally, they cover the debated topic of defibrillator therapy and the use of HCM Risk-SCD risk calculator. Dr Owens provides an overview of the treatment paradigms for HCM, touching on haemodynamic classifications, symptomatology and the evaluation of sudden death risk. What are the most common mimickers of HCM? What is Dr Owens and her heart team approach to decision making? What is the role of genetic testing in patients with HCM? This content is intended for US-based physicians.

In the second episode of our series "Conversations about Hypertrophic Cardiomyopathy", Dr Ankur Kalra sat down with Dr Ahmad Masri to have a deep-dive into the management paradigms of hypertrophic cardiomyopathy (HCM), considering the evolution of medical therapy in recent years. Dr Ahmad Masri is a Cardiologist and the Director of OHSU Hypertrophic Cardiomyopathy Center. This series is sponsored by an unrestricted educational grant from Bristol Myers Squibb. Please see www.camzyosrems.com for important safety information. Dr Kalra invites Dr Masri to guide us through his decision-making process in evaluating medical and surgical options in patients with obstructive hypertrophic cardiomyopathy. Dr Masri delves into first and second-line treatment strategies while exploring the significance of FDA-approved cardiac myosin inhibitors in the management of hypertrophic cardiomyopathy. Dr Kalra asks Dr Masri about the practical office-based clinical course for patients deemed suitable candidates to receive mavacamten. Dr Masri provides a clear and practical outline of what it entails to opt for this second-line medical therapy including the REMS programme required for therapy (www.camzyosrems.com). Dr Masri highlights the importance of looking at HCM patients holistically to find the treatment which best fits their circumstances and preferences in choosing surgical and medical therapy options. What are the available management options for patients with HCM? How does Dr Masri approach shared decision-making in the management of HCM? What are some of the practical considerations regarding the cardiac myosin inhibitor, mavacamten? This content is intended for US-based physicians.

Join Dr Ankur Kalra in this episode of our mini-series, "Conversations about Hypertrophic Cardiomyopathy," as he engages in an in-depth discussion with Dr Carolyn Yung Ho. Together, they explore the journey from symptoms to diagnosis and management options for hypertrophic cardiomyopathy (HCM). Dr Ho, Medical Director of the Cardiovascular Genetics Center and an Associate Professor at Harvard Medical School. Dr Ho offers a comprehensive examination of HCM, providing valuable insights on diagnosing the condition and distinguishing it from other conditions. The discussion addresses important questions, such as when to refer patients suspected of having HCM. The episode explores the significance of cardiac MRI in diagnosing and distinguishing HCM, with a focus on the distinctive features that aid in assessment. The differentiation between sarcomeric and non-sarcomeric forms of HCM is examined for its clinical relevance, with an emphasis on identifying individuals at risk. Dr Ho sheds light on the diagnostic tools used for risk stratification in both obstructive and non-obstructive cases of HCM. The conversation delves into management strategies for non-obstructive HCM patients, including additional approaches to alleviate symptoms such as exertional dyspnoea. The episode concludes by discussing cardiac myosin inhibition as a potential therapy, covering important considerations and providing a comprehensive checklist for initiating treatment. Additionally, the latest evidence on exercise training in HCM patients is highlighted. Tune in to gain insights into the diagnosis and management of HCM as Dr Ankur Kalra and Dr Carolyn Yung Ho illuminate this intricate cardiovascular condition. the diagnosis and management of HCM as Dr Ankur Kalra and Dr Carolyn Yung Ho illuminate this intricate cardiovascular condition. This series is supported by an unrestricted educational grant from Bristol Myers Squibb. This content is intended for US-based physicians.

“You should neither take the outcome personally nor fall into the trap of thinking that doing nothing better.” In this special episode of Parallax, we bring you Dr Ankur Kalra's thought-provoking lecture delivered at the IU School of Medicine Department of Anaesthesia Grand Rounds and introduced by Dr Nandan Anavekar. In this episode, Dr. Kalra explores the intersection of spirituality and healthcare, encouraging us to reflect on its significance for both patients and providers. Dr. Kalra begins by defining spirituality and highlighting its interconnectedness with patient care and the broader concept of life. He invites us to think about the various mechanisms behind spiritual experiences and practices, sharing his own personal journey with meditation. Examining studies on the impact of meditative practices like yoga and mindfulness on heart outcomes, he sheds light on their place in healthcare. Delving into his experiences as a physician, Dr. Kalra presents two patient cases, illustrating how he navigates disparate outcomes. Drawing from Eastern perspectives, Dr. Kalra offers insights from the Bhagavad Gita to encourage a re-evaluation of medicine beyond metrics and focusing on the effort invested in care. He raises important questions about leading a mindful life and the challenge of remaining unattached to outcomes in a metric-driven healthcare system. What does spirituality mean in the context of healthcare? How can physicians take control of their mindset? And what does the data reveal about the benefits of mindfulness in patient care?

In this week's Parallax, Dr Ankur Kalra is joined by guests, Dr Rama Ellauzi, Dr Nandan Anavekar and Dr Anthony Kashou, also known as The EKG Guy. Together, they delve into cardiovascular education and the Global Cardiology University (GCU). The genesis of GCU traces back to Dr Kashou's time as an intern at Mayo Clinic. Recognizing the challenges of postgraduate education, Dr Kashou embarked on a journey to enhance early-level training. Drawing inspiration from his own struggle to comprehend electrocardiograms (EKGs), he set out to build a comprehensive database. This eventually led to the birth of GCU. Dr Ellauzi, Dr Anavekar and Dr Kashou share their passion for education and the devotion that drew them to the GCU. They explore the vision of GCU, which revolves around creating a community space where knowledge is shared, aligning with educational trends, and empowering learners. Through scientific content evaluation and a commitment to providing premium yet affordable materials, GCU embraces community ownership. As the team has grown, teachers and students now find themselves in the same virtual room, fostering a collaborative and supportive environment. The conversation moves to the platforms and interactions offered by GCU. Dr Ellauzi and Dr Kashou shed light on the diverse formats available. They discuss the process of content vetting, emphasizing the importance of explanations and foundations for learners at all levels. They stress that GCU, serves as a complementary resource, enhancing traditional education methods for learners at different stages of knowledge acquisition. How can we empower learners in the digital age? How do we build global learning communities and cultures? When should new knowledge become part of a curriculum? Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guests: @nandananavekar, @EllauziRama, @TheEKGGuy host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In this final episode of our mini-series on value in academic medicine, Dr Ankur Kalra welcomes back Dr Nandan Anavekar, a Professor of Medicine at Mayo Clinic College of Medicine and consultant for both the Cardiovascular and Radiology Departments at Mayo Clinic, who also serves as the Program Director for the Adult Cardiovascular Diseases Fellowship program. In this inspiring conversation, Dr Anavekar and Dr Kalra discuss the education of postgraduate medical students and reflect on Dr Anavekar's role as a Program Director. Dr Anavekar shares his motivations and the moral framework he uses to approach his responsibility towards his students. The conversation then shifts towards the learning environment provided for medical students. Dr Anavekar contrasts the prevalent competitive culture and draws on Vedic philosophies to outline how we can strive for a student-centric culture that fosters a more collaborative environment and supports autonomous decision-making. Dr Anavekar asks listeners to look at medical education with fresh eyes by reframing what value means within this context. Finally, Dr Anavekar talks about the Global Cardiology University Project and his work on democratizing medicine on a global scale. How can we create a safe learning environment for medical students? What is Dr Anavekar's thoughts on the role of teachers and students in medical setting? What is Dr Anavekar's message to early-career faculty? Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: @nandananavekar, host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

In the second part of our mini-series exploring the concept of value in academic medicine, Dr. Ankur Kalra once again engages in a compelling discussion with Dr. Nandan Anavekar. Dr Anavekar, a Professor of Medicine at Mayo Clinic College of Medicine and consultant for both the Cardiovascular and Radiology Departments at Mayo Clinic, also serves as the Program Director for the Adult Cardiovascular Diseases Fellowship program. In this stimulating and thought-provoking episode, Dr. Kalra and Dr. Anavekar delve into the topic of measuring success in medicine. Dr. Anavekar puts forward the argument that the ambiguous definition of academic achievement often results in damaging biases that have long-term repercussions on the medical field. As a program director, Dr. Anavekar believes that the number of published articles should not be the only or most crucial criterion for evaluating early-career faculty. He argues that it's important to also consider the "distance travelled" by candidates. Dr. Kalra raises pertinent questions about the practical implications of this approach, and Dr. Anavekar provides candid insights into his responsibilities. The conversation also sheds light on the "publish or perish" mentality and highlights the need to prioritize patient needs over the ideals of the experts treating them. Can we move beyond binary thinking when it comes to measuring success in medicine? How does Dr. Anavekar tackle research questions? What is the true essence of being "academic"? Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: @nandananavekar, host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.

Bullying is a phenomenon that most of us are familiar with, whether through personal experience or through the stories of friends and colleagues. But what exactly is the impact of bullying on an individual and, in turn, on their community or field of work? In the context of medical science, the consequences can be particularly dire. In the latest episode of Parallax, Dr Ankur Kalra's guests are Dr Susanne Täuber and Dr Morteza Mahmoudi. Dr Täuber, an expert in organisational behaviour, was recently terminated for speaking out against discrimination at her institution. Dr Mahmoudi is a radiologist at Michigan State University and co-founder of @AcademicParity movement. Dr Mahmoudi and Dr Täuber teamed up to explore bullying in academic settings. Together with Dr Kalra they discuss why bullies thrive in such environments and the ways institutions enable such behaviour. Dr Täuber offers solutions and a critical overview of institutional narratives, while Dr Mahmoudi highlights the long-term effects on academic work and medicine. They call for action against toxic behaviour and for stakeholders to eliminate incentives for universities to support perpetrators. What prompted Dr Mahmoudi to write about academic bullying? How do we disrupt toxic behaviours? What is Dr Täuber's and Dr Mahmoud's message to individuals who have been targeted by perpetrators? Join the petition to reinstate Dr Susanne Täuber: https://openletter.earth/reinstate-susanne-tauber-protect-social-safety-and-academic-freedom-at-the-rug-ed83c085 Support Dr Susanne Täuber: https://www.gofundme.com/f/crowdfunding-campaign-to-support-susanne-tauber Resources: Täuber S & Mahmoudi M. Disrupting targets' dependency on bullies. Science 2022. https://doi.org/10.1126/science.abo3412 Mahmoudi M. Academic bullying slows the evolution of science. Nat Rev Mater 2023. https://doi.org/10.1038/s41578-023-00549-x Mahmoudi M. Academic bullying: How to be an ally. Science 2021. DOI: 10.1126/science.abl7492 Mahmoudi M. A survivor's guide to academic bullying. Nat Hum Behave 2020. https://doi.org/10.1038/s41562-020

In 2018, the loss of a friend to suicide compelled Dr Anavekar to embark on a profound journey of contemplative self-exploration. Now, he uses his experience to encourage and guide trainees to pose thought-provoking questions that challenge the status quo of the materialistic approach to medicine, ultimately leading to a more outcome-focused perspective. In this week's episode of Parallax, Dr Ankur Kalra sits down with guest Dr Nandan Anavekar, a Professor of Medicine at Mayo Clinic College of Medicine and Science. Dr Anavekar also serves as a consultant for both the Cardiovascular and Radiology Departments at Mayo Clinic and is the Program Director for the Adult Cardiovascular Diseases Fellowship program. In this episode, Dr Nandan Anavekar emphasizes the importance of inner exploration for physicians. He encourages questions such as "Who am I?" and "What is this world that I reside in?" to foster a deeper understanding of the human condition and patient care. Dr Anavekar also addresses the current cultural shift in cardiology toward measuring success by material possessions and procedures, advocating instead for a focus on outcomes. Dr Kalra probes further, asking how this philosophy can be applied in the Western, and particularly the US healthcare system. What is the Global Cardiology University project? How does Dr Anavekar encourage trainees to re-examine their role in patient care? What is his advice to our listeners?

In the latest episode of Parallax, Dr. Ankur Kalra invites Dr. Vijay Rao, the Governor of the Indiana Chapter of the American College of Cardiology, to share his experience and insights with the audience. Dr. Rao, who also serves as the Director of Heart Failure, Cardio-oncology, and Co-Director of Anticoagulation at Franciscan St. Francis Health, discusses what initially drew him to the Indiana State Chapter of ACC. As Dr. Kalra asks Dr. Rao about the ways in which early career faculty members can get involved with the organization at a state level. Dr. Rao shares his insider tips and highlights key events where individuals can further their participation. Dr. Rao also sheds light on the governorship election process and shares his learnings from his new role. He emphasizes the importance of advocacy and describes the chapter's efforts to amplify the voice of cardiologists in relation to Roe v. Wade. Dr. Rao encourages healthcare professionals to reframe their perspectives and get involved with advocacy. Dr Rao shares his future plans as a governor and previews the upcoming annual event of the Indiana Chapter. Join Dr. Kalra and Dr. Rao in this engaging and thought-provoking episode of Parallax. How can you get involved with your local ACC chapter? How can you improve your leadership skills? What is Dr Rao's advice for our listeners?

“We're providing about 20,000 different ingredients in our diet to a gut microbiome that has 4 million genes. And they're processing these 20,000 ingredients at a flood of chemicals.” In this episode of Parallax, Dr Ankur Kalra speaks with Dr. Momchilo Vuyisich, co-founder and chief science officer of Viome Life Sciences. Dr Vuyisich shares his personal journey with rheumatoid arthritis and how it led him to explore the intersection of nutrition and the gut microbiome function. He explains how the complexity of nutrition and the compounds generated by the gut microbiome can impact our health. We learn more about three compounds produced by our gut microbiome that have a strong connection with heart disease. Through this conversation, Dr Vuyisich invites us to reframe our approach to nutrition and prevention as a question of food education and data-driven science. What is the effect of red meat and processed food on our gut biome? What can we learn about prevention through understanding gut biome function? How can data-driven science help us make informed choices about nutrition and health? Questions and comments can be sent to “podcast@radcliffe-group.com” and may be answered by Ankur in the next episode. Guest: Dr Momo Vuyisich, host: @AnkurKalraMD and produced by: @RadcliffeCARDIO.