Podcasts about Menin

In a plan that's now being echoed by the Trump administration, New York City has helped close to 400,000 public school students and their families pay for college by creating savings accounts, which include start-up seed money. Joining NY1's Errol Louis to discuss the program was City Council Speaker Julie Menin, who helped launch NYC Kids RISE in 2015 when she was the city's Consumer Affairs Commissioner. In their conversation, Menin also reflected on her career and her path into politics, including her work rebuilding Lower Manhattan after the Sept. 11 attacks and her push to release long-withheld 9/11 files. She also outlined her responsibilities as council speaker and her current priorities, including an oversight hearing on Legionnaires' disease; a proposed ban on horse-drawn carriages; and the creation of an office dedicated to insurance accountability.

A.M. Edition for Aug. 12. Centrist David Crowley scores an electoral upset in Wisconsin, narrowly defeating Democratic socialist Francesca Hong in a race to secure the Democratic nomination for governor. WSJ's Damian Paletta says Crowley's victory could mark a turning point for progressives. Plus, New York City launches a sweeping investigation into four prediction markets – probing Polymarket, Kalshi, Coinbase and Gemini Titan for alleged deceptive marketing practices and the targeting of minors. And could one of Hollywood's oldest studios be relocating from Tinseltown to Music City? Luke Vargas hosts. Sign up for the WSJ's free What's News newsletter. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Konuğumuz iktisatçı-yazar Mahfi Eğilmez ile iklim krizinin ekonomik boyutunu, büyüme anlayışını, karbon fiyatlandırmasını, yeşil dönüşümün maliyetlerini ve gezegenin sınırları içinde sürdürülebilir bir ekonomik düzenin mümkün olup olmadığını konuşuyoruz. 

This fall, 2000 2-year-olds will be enrolled in the city's free 2-K Program. WFUV's Mia Barth has more on New York City's efforts to provide more affordable childcare. In Connecticut, Governor Ned Lamont announced a virtual grocery card that allows those who lost their SNAP benefits to buy food. WFUV's Sienna Reinders explains who's eligible and how it'll work. At City Hall, Speaker Julie Menin spoke this morning for action against illegal sales of E-Bikes in New York City. WFUV's Tahlia Pearson highlights safety concerns and advocates' calls to reduce deaths and injuries. In Newark, New Jersey, another death was reported at Detention Center Delaney Hall. WFUV's Lainey Nguyen tells us about the situation and its call to close the detention center. Host/Producer: Xenia Gonikberg Editor: Nathan Ray Reporter: Mia Barth Reporter: Sienna Reinders Reporter: Tahlia Pearson Reporter: Lainey Nguyen Theme Music: Joe Bergsieker

"Menin kihloihin, koska en uskaltanut kieltäytyä kosinnasta" -kuuntelija. Kaheleilla on yksi yhteinen piirre, he eivät osaa kieltäytyä erilaisista pyynnöistä ja ovat sen takia joutuneet erilaisiin, jopa epämukaviin tilanteisiin. Pinja taistelee erilaisia myyjiä vastaan kun taas Iyad ottaa töissä niin paljon vastuuta että joutui burn outtiin.Ainutlaatuisen viihdyttävä podcast. Kaksi nuorta aikuista, jotka yrittävät tehdä elämällään enemmän sekä kokea paljon. Pinja ja Iyad ovat Kaheleita, joilla on vain vähän parempi huumorintaju kuin muilla. He ottavat kantaa ajankohtaisiin ilmiöihin sanomalla suorat sanat. Uusi jakso torstaisin klo 7:00!KUUNTELE KAHELI+ JAKSOT TÄÄLTÄ: https://podcasters.spotify.com/pod/show/kaheli/subscribeSeuraa meitä:Instagram https://www.instagram.com/kaheliofficial/TikTok https://www.tiktok.com/@kaheliofficial

Başarıyı gerçekten nasıl ölçüyorsunuz? Maaşınızla mı? Unvanınızla mı? Sahip olduğunuz ev, araba veya yatırımlarla mı? Yoksa sabah uyandığınızda hissettiğiniz mutlulukla mı? Bu videoda başarıyı ölçmenin farklı yollarını ele alıyoruz ve çoğu insanın gözden kaçırdığı önemli bir gerçeği konuşuyoruz: Başarı sadece sayılarla ölçülemez. Toplum bize gelir, kariyer, diploma ve statü gibi geleneksel başarı kriterleri sunar. Ancak hayatın en değerli unsurları çoğu zaman bu tabloların dışında kalır. Mutluluk, huzur, sağlık, güçlü ilişkiler, anlam duygusu ve kişisel gelişim gibi faktörler de gerçek başarının ayrılmaz parçalarıdır. Bu videoda; ✅ Geleneksel başarı kriterlerini ✅ Kendi başarı ölçütlerinizi nasıl oluşturabileceğinizi ✅ Başarıyı değerlendirmek için kullanabileceğiniz üç farklı pencereyi ✅ Ölçülebilir ve ölçülemeyen başarı kavramlarını ✅ Hayatınızın pusulasını oluşturacak güçlü koçluk sorularını birlikte inceleyeceğiz. Bu bölümün sonunda başarıyı başkalarının kriterleriyle değil, kendi değerleriniz doğrultusunda değerlendirmeye başlayacaksınız. Çünkü ölçmediğiniz şeyi yönetemezsiniz. Ama yanlış şeyi ölçerseniz, hayatınızı da yanlış yöne götürebilirsiniz. Videoyu izledikten sonra yorumlarda şu soruyu cevaplayın: “Siz başarıyı bugün hangi kriterlerle ölçüyorsunuz?”

City Council Speaker Julie Menin (D-5, Upper East Side) talks about the latest news from City Council and takes calls from listeners. Photo:  Speaker Julie Menin speaking at a rally for Hands Off NYC (Photo courtesy of New York City Council) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

İran Savaşı'nın başlaması ve “mutlak butlan” kararının ardından yapılan örtülü faiz artışı ve ek sıkılaştırma adımlarının ne zaman gevşetileceği konusu piyasaların en önemli gündem maddelerinin başında geliyor. Zira her iki meselenin ardından atılan adımlar bu yılın ikinci çeyreği için gevşemesi beklenen finansal koşulları daha da sıkılaştırdığı için reel sektörün üzerindeki yük gereğinden fazla artmış durumda.

Crews have been stabilizing the Midtown high-rise in danger of collapse... Mamdani vows to disclose addresses of buildings that test positive for Legionella bacteria - Council Speaker Menin thinks the city shouldn't wait for the tests full 453 Wed, 08 Jul 2026 09:54:12 +0000 YJIjjJWS7Z40lVTQzCahn8rzJaK3q1jD news 1010 WINS ALL LOCAL news Crews have been stabilizing the Midtown high-rise in danger of collapse... Mamdani vows to disclose addresses of buildings that test positive for Legionella bacteria - Council Speaker Menin thinks the city shouldn't wait for the tests The podcast is hyper-focused on local news, issues and events in the New York City area. This podcast's purpose is to give New Yorkers New York news about their neighborhoods and shine a light on the issues happening in their backyard. 2024 © 2021 Audacy, Inc.

Festivalyje „IŠKROVOS“ baigėsi menininkų atranka į meno galeriją „GIJOS“. Šiemet organizatoriai sulaukė net 140 menininkų paraiškų iš Lietuvos ir užsienio.Laidoje „Be problemų“ svečiavosi paraiškų vertintojai – menininkė, festivalio „IŠKROVOS“ meninės programos ir projektų koordinatorė Milda Paužolytė ir dainininkas, kuratorius ir kultūros renginių prodiuseris Vaidas Bartušas.Ved. Unė Liandzbergytė ir Rimvydas Černiauskas.

Prof. Dr. Seda Demiralp ile Kemal Kılıçdaroğlu'nun CHP'ye mutlak butlan olarak atanmasından sonra seçmende oluşan duyguyu ve bunun seçime olası etkilerini konuştuk. İyi seyirler...

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Oncology Brothers podcast, we dived deep into the complexities of relapsed refractory acute myeloid leukemia (AML) with expert guest Dr. Joshua Zeidner, Chief of Leukemia Research at the University of North Carolina. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: ⁠X/Twitter: https://twitter.com/oncbrothers ⁠Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ Join us as we explore two challenging cases: Revumenib (menin inhibitor) demonstrated an overall response rate of ~63% in heavily pre-treated KMT2A rearrangement-positive AML patients based on the AUGMENT-101 study, with QTc prolongation and CYP3A4 drug interactions as key monitoring considerations. FLT3 inhibitors like gilteritinib and quizartinib play an important role in MRD-positive FLT3 ITD/NPM1-mutated AML post-transplant, with the MORPHO trial supporting gilteritinib as maintenance therapy.  Menin inhibitors may have a broader role in high-risk AML including NPM1-mutated disease, and re-evaluating mutational profiles at relapse is critical for optimal treatment selection.  Careful monitoring of side effect profiles, drug interactions, and MRD status is essential when navigating targeted therapy decisions in relapsed refractory AML. Throughout the episode, we discuss key practical points, including the importance of monitoring for QTc prolongation and the impact of drug interactions with CYP3A4 inhibitors. Tune in for an informative discussion that sheds light on the latest advancements in targeted therapies for AML and the evolving landscape of treatment options. Don't forget to like, subscribe, and check out our other episodes in the challenging case series, treatment algorithms, and conference highlights! #AcuteMyeloidLeukemia, #MeninInhibitor, #FLT3Inhibitor, #Hematology, #OncologyBrothers

This week, Mayor Zohran Mamdani and City Council Speaker Julie Menin appeared to set aside their differences to advance a new budget solution: scaling back a lucrative tax credit used by wealthy business owners to help close the city's budget gap. The proposal, which targets what's known as the Pass-Through Entity Tax (PTET) credit, was swiftly rejected by Gov. Kathy Hochul. NY1 investigative reporter Courtney Gross, and political reporters Bobby Cuza and Kelly Mena break down how the tax credit works, who benefits most, and why the governor pushed back. Plus: Did Mayor Mamdani take a political hit? His endorsement of Lindsey Boylan fell short in a special election for a Manhattan City Council seat, raising questions about his influence. Meanwhile, the mayor waded into international controversy after appearing to pick a fight with the King over a disputed gem. The "Off Topic" team looks at Mamdani's busy week.

A MRV é a maior empresa de habitação da América Latina. São 46 anos de história, mais de 600 mil apartamentos entregues e 1,8 milhão de brasileiros que hoje vivem em um imóvel construído por eles. Mas chegar até aqui não foi simples. Neste episódio, Rafael Menim senta com Fernando Ferreira, estrategista-chefe da XP e Ygor Altero, head de Real Estate no Research da XP, para falar abertamente sobre os ciclos do mercado imobiliário, os desafios de liderar uma das maiores construtoras do país e o momento de virada que a MRV está vivendo agora.Durante a conversa, Rafael conta como o Minha Casa Minha Vida transformou o setor e por que ele veio para ficar, explica o déficit de 6 milhões de moradias e os motivos pelos quais ele simplesmente não some, e faz um balanço honesto sobre a aventura da Résia nos Estados Unidos — o que deu errado e o que a empresa planeja para o futuro.Ele também fala sobre os desafios práticos do negócio, como a escassez de mão de obra e a pressão de custos, e detalha o novo ciclo de excelência da MRV, focado em rentabilidade, desalavancagem e geração de caixa. Tudo isso sem deixar de lado a história pessoal: de estagiário a CEO, 27 anos dentro da mesma empresa fundada pelo seu pai.-----------------------------------------------------------------------------Investir com a XP Investimentos é fácil, basta criar o seu cadastro e em minutos você já pode começar a investir: https://t2m.io/youtube-aqsAcompanhe todos os conteúdos da XP em https://t2m.io/8cxPp6xParticipe do canal do Telegram: https://t.me/xp_investimentosConfira nosso Instagram: https://www.instagram.com/expertxp/Glossário financeiro: https://conteudos.xpi.com.br/conteudos-gerais/glossario-financeiro/-----------------------------------------------------------------------------

In this podcast, experts Naval G. Daver, MD; Amir Fathi, MD; Guillermo Garcia-Manero, MD; and Aditi Shastri, MD, discuss current applications for menin inhibitors in patients with acute leukemia, combination approaches under investigation, and managing treatment-related adverse events with menin inhibitors.

24.04.2026 | Dijital Hayat Bölüm582 - TRT Radyo1 | "Dijitalleşmenin İklim Krizine Etkileri" Dr. Bilal Eren'in hazırlayıp, sunduğu Dijital Hayat programımızda bu hafta, Boğaziçi Üniversitesi İklim Değişikliği Araştırma Merkezi Yönetim Kurulu Üyesi ve İklim Bilimci Prof. Dr. Murat Türkeş ile; - Dijitalleşme ile İklim Krizi Arasındaki İlişki Nedir? - Dijitalleşmenin İklim Krizine Etkileri? - Dijitalleşme, İklim Krizi Sorununun mu, Çözümünün mü Parçası? - Karbon Ayak İzi, Sera Gazı, Elektronik Cihaz Kullanım Alışkanlıklarımız, E-Atık, Elektronik Cihaz Üretiminde Kullanılan Madenler gibi Hangi Başlıklar, İklim Krizinde Etkili? - Bireysel Dijital Kullanım Alışkanlıklarımız Nasıl Olmalı? - Birleşmiş Milletler İklim Değişikliği Konferansı (COP) Organizasyonu Konuyla İlgili Neler Yapıyor? - Türkiye'de Kasım 2026'de Düzenlenecek COP Organizasyonundan Neler Bekliyorsunuz? - Türkiye, İklim Krizi Mücadelesinde Fark Yaratabilir mi? Başlıklarını konuştuk. Dijital Hayat, her cuma saat 15:30'da TRT Radyo1 mikrofonlarında canlı yayında... Tüm geçmiş ve gelecek yayınlarımız için; Web: https://www.dijitalhayat.tv

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Menin Inhibitors in Acute Myeloid Leukemia | Faculty Presentation 2: Potential Role of Menin Inhibitors as a Component of Combination Therapy — Amir Fathi, MD CME information and select publications

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Menin Inhibitors in Acute Myeloid Leukemia | Faculty Presentation 1: Biology Underlying the Utility of Menin Inhibitors in Acute Leukemias: Use of These Agents as Monotherapy — Eunice S Wang, MD CME information and select publications

Featuring perspectives from Dr Amir Fathi and Dr Eunice S Wang, including the following topics: Introduction: Overview — Biopharmacologic Considerations (0:00) Menin Inhibitor Monotherapy (21:51) Differentiation Syndrome (36:12) Menin Inhibitor Combination Approaches (45:15) Future Directions (49:59) PARADIGM — Randomized Phase II Trial (53:24) CME information and select publications

Why Brotherhood Matters for MenIn this episode, we break down why men were never meant to do life alone. Isolation is not strength—it is risk. We talk about how isolation impacts your faith, leadership, and family, and what the Bible says about building real brotherhood.What We CoverThe Danger of IsolationIsolation weakens men over time and creates space for poor decisions and spiritual attacks. When a man disconnects, his family feels it first.

Sivas'ta devrilen beton pompasının çarpmasıyla kalıbın içine düşen 23 yaşındaki gencecik bir işçinin yarım kalan hayalleri… Amasya'da, torun sevecek yaşta, 65 yaşında bir işçi ağabeyimizin inşaatın çatısından düşerek hayatını kaybetmesi… Eskişehir'de elektrik arızasını gidermeye çalışırken akıma kapılan işçi kardeşimiz… İzmir'de arıtma tesisinde kullandığı atık toplama kamyonu çamurla dolu çukura düşen işçi kardeşimiz… Ve Dilovası'ndaki Çolakoğlu Metalurji… Birkaç metrelik basit bir yaşam halatının çok görülmesi yüzünden metrelerce yükseklikten beton zemine çakılarak yaşamını yitiren sınıf kardeşlerimiz… 8 Kasım'da Dilovası'nda Ravive Kozmetik adlı parfüm fabrikasında, bir dizi ihmal sonucu hayatını kaybeden 3 evladımız, 4 kız kardeşimiz…Ülkede resmen her gün yeni bir isimsiz mezar kazılıyor, fabrikalardan, şantiyelerden, tersanelerden, madenlerden çıkan cansız bedenler bu isimsiz mezarları dolduruyor. Yaşanan ölümlerin hiçbiri tesadüf değil. Hiçbiri talihsizlik değil. Hiçbiri işçinin bir anlık dalgınlığının sonucu değil. Ve en önemlisi, hiçbiri “görünmez kaza” değil. Her biri göz göre göre gelen, patronların kârını her şeyin üstünde tutan bu düzenin eseri. Ve sermaye düzeni bu cinayetlerin sadece faili değil, aynı zamanda sorumluları aklamanın, cezasızlıkla cesaretlendirmenin de aracı. 3'ü çocuk 7 işçi kardeşimizin yaşamını yitirdiği Ravive Kozmetik davası en çarpıcı örneklerden birisiydi. Ravive Kozmetik'te fabrika binası kaçaktı. İşçiler kayıt dışı ve sigortasız çalıştırılıyordu. Fabrikada herhangi bir güvenlik önlemi alınmadığı gibi, denetim de yapılmıyordu. Bu şartlarda göz göre gelen iş cinayetinin tek sorumlusu yalnızca patron değil. Patrona bu denli göz yuman, adeta her türlü denetimden muaf tutan düzenin kurumları da sorumluydu. Giden geri gelmiyor ama işçi ailelerinin yüreğine bir nebze olsun su serpecek şey “adaletin yerini bulması” olurdu. Ne var ki devlet, mahkemenin kendisini emekçi halktan, sorumluları da adaletten kaçırmaya çalıştı. Mahkeme heyeti türlü ihlaller yaptı, işçi ailelerinin avukatlarının her türlü talebini reddetti. Emekçi halkın adalet talebi, sermayenin yasalarının hâkim olduğu mahkeme koridorlarında yankısız kaldı. Birkaç yetkilinin feda edildiği, patronların “taksir” kelimesinin arkasına saklanarak kendini kurtardığı, caydırıcılıktan uzak cezalarla geçiştirilen bir tablo ortaya çıktı. Soma'da, Ermenek'te, Amasra'da gördük. İliç'te, Gayrettepe'de, Dilovası'nda görüyoruz. Bu durumun değişmesi gerek ama bu, servetinden başka bir şey düşünmeyen patronların insafına da onları koruyup kollayan yasalarla sözde adaleti sağlayacak mahkemelerin vicdanına da bırakılamaz. Elbette mahkemelerde sorumluların ceza alması için mücadele edeceğiz. Elbette işyerlerinde, fabrikalarda gerekli tedbirlerin alınmasını sağlamak için mücadele edeceğiz. Ama yarım hayatların önüne gerçekten geçmek için, fabrikalarda, işyerlerinde patronların orman kanunlarının hüküm sürdüğü değil, işçi sağlığının ve iş güvenliğinin gereklerini hâkim kılacak bir düzen gerek. Patronların işçinin hayatından çalmasını engellemek için işçi denetimi gerek. Bu da ancak örgütlenerek mümkün. Tek tek fabrikalarda, işyerlerinde sendikalarımızda örgütlenerek... Ama tek bir kişi daha eksilmeyeceğiz diyorsak o zaman bu kanlı çarkın son bulması, patronların kâr hırsının değil, işçi sınıfının iktidarının hâkim olması gerek. Bunun için tek tek fabrikalarda sendikalarda örgütlenmek yetmez, bunun için çağrımız devrimci sınıf siyasetinde örgütlenme çağrısı. 28 Nisan “İş Cinayetlerinde Hayatını Kaybeden İşçileri Anma Günü”. İlk kez 1914'te 28 Nisan günü, Kanada'da bir mahkemenin iş kazalarında patronların sorumlu olduğuna dair verdiği bir karara atfen bu tarih kabul edilmiş. 28 Nisan'da onları anacağız. 28 Nisan'dan sonra 1 Mayıs var. 1 Mayıs meydanlarında, iş cinayetlerinde yitirdiğimiz işçiler için de yürüyeceğiz. Hem onların hesabını sormak hem tek bir kişi daha eksilmemek için sınıf siyasetinin sesini yükseltmek için!

NYC Council member Tiffany Cabán (District 22, Astoria, Jackson Heights, East Elmhurst, Woodside and Rikers Island) talks about the Delivery Protection Act, which would regulate "last mile" delivery subcontracting by retail giants like Amazon, and Mayor Mamdani's first 100 days in office. Photo: An Amazon Prime delivery van parked in Hillcrest, Queens. Credit: Tdorante10 via Wikimedia Commons.    

It's Casual Friday on The Majority Report   On today's program:   Julie Menin, the multimillionaire Speaker of the New York City Council, is opposing Mayor Zohran Mamdani's budget proposal by responding to a moderate tax increase on the ultra-wealthy with cuts to city programs. Unrelated, Menin owns a $22 million mansion in the Hamptons and a $7 million apartment on the Upper East Side. No conflict of interest there.   Heather 'Digby' Parton joins the program to recap the week's news. Check out Digby's work at Salon as well as her blog Hullabaloo. Topics include the American right-wing's desperation to keep Victor Orban in power in Hungary, Trump firing all the women around him, Iran and more. Trump In the Fun Half:   Harry Enten presents polling that shows Congressional democrats' ratings are in the toilet.   Joe Rogan gets very uncomfortable every time Theo Von brings up the genocide in Palestine.   Matt Gaetz tells Benny Johnson about an alleged briefing he got from a uniformed servicemember about an interspecies breeding program between aliens and people captured in warzones operated by the CIA.   Karoline Leavitt is fighting to keep her job by flattering Trump in typical North Korean style ass kissing.   Megyn Kelly is not happy with the Trump's administration's handling of the war of Iran.   A couple of pastors from Pete Hegseth's denomination perform unconvincing toxic masculinity - these guys are certainly not hiding from themselves.   all that and more   Preorder Molly Crabapple's book: Here Where We Live is Our Country.   To connect and organize with your local ICE rapid response team visit ICERRT.com The Congress switchboard number is (202) 224-3121. You can use this number to connect with either the U.S. Senate or the House of Representatives. Follow us on TikTok here: https://www.tiktok.com/@majorityreportfm Check us out on Twitch here: https://www.twitch.tv/themajorityreport Find our Rumble stream here: https://rumble.com/user/majorityreport Check out our alt YouTube channel here: https://www.youtube.com/majorityreportlive Gift a Majority Report subscription here: https://fans.fm/majority/gift Subscribe to the AMQuickie newsletter here: https://am-quickie.ghost.io/ Join the Majority Report Discord! https://majoritydiscord.com/ Get all your MR merch at our store: https://shop.majorityreportradio.com/ Get the free Majority Report App!: https://majority.fm/app Go to https://JustCoffee.coop and use coupon code majority to get 10% off your purchase Check out today's sponsors: WILD GRAIN: Get $30 off your first box + free Croissants in every box. Go to Wildgrain.com/MAJORITY to start your subscription..   SUNSET LAKE: Use coupon code "Left Is Best" (all one word) for 20% off of your entire order at SunsetLakeCBD.com  Follow the Majority Report crew on Twitter: @SamSeder @EmmaVigeland @MattLech On Instagram: @MrBryanVokey Check out Matt's show, Left Reckoning, on YouTube, and subscribe on Patreon! https://www.patreon.com/leftreckoning Check out Matt Binder's YouTube channel: https://www.youtube.com/mattbinder Subscribe to Brandon's show The Discourse on Patreon! https://www.patreon.com/ExpandTheDiscourse Check out Ava Raiza's music here! https://avaraiza.bandcamp.com

In this podcast, experts Naval Daver, MD; Courtney DiNardo, MD; and Eunice Wang, MD; discuss the rationale for treatment with menin inhibitors—and the data showing their efficacy and safety—in acute myeloid leukemia (AML).

Former New York City Councilman Bob Holden calls in to discuss Council Speaker Julie Menin's tweet about combating Islamophobia, which Sid and Holden criticize in light of recent terrorist attacks and rising antisemitism; Holden argues Menin and most City Council Democrats cater to the far-left for ambition and electoral security. They discuss internal Council dynamics, Holden's view that prior Speaker Adrienne Adams was the worst, and Sid's belief Menin is more dangerous because she presents as moderate. Both condemn Menin's actions against Councilwoman Vicki Paladino and praise Paladino's popularity and outspoken views. Learn more about your ad choices. Visit megaphone.fm/adchoices

Chalkbeat, Kamar Samuels' cabinet: Your guide to the Education Department's new leadership team https://www.chalkbeat.org/newyork/2026/03/05/kamar-samuels-nyc-education-department-cabinet-leadership-team/ NY Times, U.S. Schools Are Betting Big on A.I. Will New York City Be Next?, https://www.nytimes.com/2026/03/02/nyregion/nyc-ai-schools-mamdani.html Petition calling for Moratorium on AI https://actionnetwork.org/petitions/please-enact-a-two-year-moratorium-on-the-use-of-ai-in-nyc-public-schools?clear_id=true Why bills restricting protests around schools are unwise and unfair by Rasheedah Brown-Harris, https://nycpublicschoolparents.blogspot.com/2026/03/why-bills-restricting-protests-around.html Columbia Spectator, Demonstrators outside of City Hall protest ‘buffer zone' legislation to limit protests outside schools and religious spaces, [https://www.columbiaspectator.com/city-news/2026/03/02/demonstrators-outside-of-city-hall-protest-buffer-zone-legislation-to-limit-protests-outside-schools-and-religious-spaces At hearing, Menin gets mixed feedback on her protest barrier billhttps://www.cityandstateny.com/politics/2026/02/hearing-menin-gets-mixed-feedback-her-protest-barrier-bill/411699/ Unions, NYCLU Slam Bills That Would Grant Police More Power Over Protestshttps://www.thecity.nyc/2026/02/25/faculty-unions-menin-protest-bill/ What to Know About the ‘Abortion Clinic' Law Being Used to Charge Don Lemonhttps://www.nytimes.com/2026/01/30/us/politics/face-act-lemon-explainer.html AQE letter, Tell City Council: NO NYPD buffer zones, protect free speech, protect students!https://actionnetwork.org/letters/tell-city-council-no-nypd-buffer-zones-protect-free-speech-protect-students

Mental Wealth: Why Emotional Intelligence Is the Real Power Move for MenIn a world that constantly tells men to focus on money, success, and status, one of the most important skills for long-term success is often ignored — emotional intelligence.Many men are taught to suppress emotions rather than understand them. Over time, that lack of emotional awareness can lead to burnout, relationship struggles, isolation, and mental health challenges.In this episode of SAUNAIE, we explore why emotional intelligence is one of the most powerful tools a man can develop for leadership, personal growth, and mental well-being.You'll learn why emotional awareness isn't weakness — it's a strategic advantage that improves communication, decision-making, and long-term success.If you've ever felt disconnected, misunderstood, or emotionally overwhelmed while trying to maintain discipline and focus, this conversation will help you understand why.What You'll Learn in This Episode• What emotional intelligence actually is and why it matters• The five core components of emotional intelligence• Why many men struggle with emotional awareness• How suppressed emotions affect mental health and relationships• Practical ways to build emotional intelligence in daily life• How emotional intelligence improves leadership and communication• Why self-awareness is the foundation of personal growthKey TakeawayTrue success isn't just about external achievements like money, status, or productivity.Real success also requires mental clarity, emotional awareness, and internal stability.Developing emotional intelligence helps you build stronger relationships, make better decisions under pressure, and maintain peace of mind while pursuing your goals.This is what we call mental wealth.Join the SAUNAIE CommunityThe conversations don't stop when the episode ends.Visit the SAUNAIE website to join the growing community focused on:• Mental health• Personal growth• Discipline• Self-awareness• Building stronger menSubscribe to the email list to receive new episodes, insights, and resources designed to help you grow mentally and emotionally.Share the EpisodeIf this episode resonated with you, share it with someone who may benefit from the conversation.Mental health discussions become more powerful when more people are willing to talk about them.Connect With SAUNAIEPodcast: SAUNAIEListen on: Apple Podcasts | Spotify

New York City Council Speaker Julie Menin makes her debut on the morning show with Sid to discuss Mayor Mandani's warning that property taxes could rise 9.5% if Albany, under Governor Hochul, does not raise income and corporate taxes. Menin says only the City Council has the authority to raise property taxes and states the Council has made clear any property tax increase is not up for discussion during an affordability crisis, nor are cuts to essential services. She argues the city can find savings elsewhere, highlighting escalating public sector and retiree healthcare costs (nearly $11 billion, up from $6 billion five years ago) and describing her healthcare accountability office as a way to save an estimated $2 billion annually by leveraging city purchasing power and renegotiating hospital pricing disparities. She also cites reducing reliance on no-bid contracts as another major savings opportunity, and notes upcoming budget hearings and negotiations leading to a June 30 budget deadline. Learn more about your ad choices. Visit megaphone.fm/adchoices

Councilwoman Joann Ariola calls into the show to discuss her relationships with figures like Julie Menin and Adrienne Adams, as well as their influence in New York City's political landscape. Ariola highlights Menin's effectiveness as a city council speaker and reflects on Adams joining Kathy Hochul's ticket for re-election. Transitioning to the city's pressing issues, Ariola critiques Mayor Mamdani for inadequate responses to street homelessness, particularly during a cold snap that resulted in several deaths. Ariola argues for more proactive and compassionate measures, indicating a significant alignment among council members in holding the administration accountable. Learn more about your ad choices. Visit megaphone.fm/adchoices

New York City Council speaker Julie Menin (D-5, Upper East Side) talks about the council's priorities, working with Mayor Mamdani, and new proposals—including year-round outdoor dining.

Councilwoman Vickie Paladino calls in to discuss her disappointment and anger towards New York City Council Speaker Julie Menin. Despite initially supporting Menin's bid for the position and expecting a centrist leadership approach, Paladino feels betrayed by Menin's public criticism. Paladino explains that she had a positive conversation with Menin before the criticism and maintains that the handling of the situation was inappropriate. She emphasizes her commitment to her district and her open communication across political lines, strongly defending her actions and asserting her First Amendment rights. Paladino also highlights the need for respectful and transparent interactions within the council. Learn more about your ad choices. Visit megaphone.fm/adchoices

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

Julie Menin, the presumptive next Speaker of the New York City Council, joined host Ben Max and Andrew Rein, president of Citizens Budget Commission, for a conversation at New York Law School on her path to the speakership, her priorities when she takes the position in January, how she plans to work with Mayor Zohran Mamdani, and more. The event took place on December 10, 2025 and was hosted by NYLS' Center for New York City and State Law and Citizens Budget Commission. Menin declared victory in the speaker race in late November, and will have to be officially voted into the position by her Council colleagues in early January. (Ep 553)

Following right-wing Democrat Julie Menin's victory in the race for City Council Speaker, we spoke with Brandon West, a former member of the City Council's central staff, about how Menin and her supporters outmaneuvered progressives, the powers she will wield as speaker and how she might try to obstruct Zohran Mamdani when he is mayor.

Eksik Olan'ın bu bölümünde Ömer Çeşit ile Alp Kozanoğlu, Mike Davis'in kült eseri “Gecekondu Gezegeni” üzerinden şehirleşmenin karanlık yüzünü tartışıyor. 2003'te yayımlanan kitap, hızla büyüyen gecekondu yerleşkelerini ve neoliberal düzenin yarattığı yapısal eşitsizlikleri mercek altına alıyor. Mega-gecekondu kentlerinin kendi iç dinamikleri, kültürel etkileri ve ekolojik sonuçları konuşuluyor. Learn more about your ad choices. Visit megaphone.fm/adchoices

Featuring an interview with Dr Ghayas Issa, including the following topics: Mechanism of action and efficacy of menin inhibitors (0:00) Presentation and management of differentiation syndrome (13:31) Role of menin inhibitors in other cancers (18:19) Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51) Mechanisms of resistance to menin inhibition in AML (26:53) Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31) Mechanism of action of menin inhibitors as differentiation agents (38:05) Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55) Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25) Other investigational therapeutic strategies in AML (54:39) CME information and select publications

Dr Ghayas Issa from The University of Texas MD Anderson Cancer Center in Houston discusses data guiding the use of menin inhibitors for patients with acute myeloid leukemia and select alterations. CME information and select publications here.

Featuring a slide presentation and related discussion from Dr Ghayas Issa, including the following topics: Evolution of menin inhibitors for acute myeloid leukemia (AML) (0:00) Side effects of menin inhibition (10:54) Mechanisms of resistance to menin inhibition in AML (15:08) CME information and select publications

On September 20th, 1917, at the Battle of Menin Road, Private Roy Inwood lay in the mud east of Ypres. His brother had died at Pozières the year before. In three hours, Roy would earn the Victoria Cross. The day after, he'd be dead.Nearby, three brothers from Petersham waited with their unit. By nightfall, their mother would have lost all three sons.After weeks of catastrophic failures under General Gough, Field Marshal Haig transferred command to General Herbert Plumer. In this episode, Mat McLachlan reveals how Plumer's methodical genius transformed the offensive: three weeks of preparation, limited objectives, overwhelming firepower—one gun for every five yards of front—and revolutionary tactics that reversed traditional doctrine.From predawn assembly through torrential mist to the devastating creeping barrage, we follow the 1st and 2nd Australian Divisions executing what Charles Bean called "probably their zenith"—the most perfectly coordinated attack of the war.Why did German counter-attacks fail so catastrophically? How did Plumer's "bite and hold" change tactical doctrine? What drove Roy Inwood to advance alone through his own barrage—twice?"Nothing I have heard in this world or can in the next could possibly approach its equal." - Australian soldier describing the barrageEpisode Length: 42 minutesFeatures: Frank Hurley's battlefield diary, German assessments of defensive collapse, and the Seabrook brothers' final day.Next Episode: Polygon Wood—the high point of the offensive.Presenter: Mat McLachlanProducer: Jess StebnickiReady to walk the battlefields? Join Mat's exclusive European tours: https://battlefields.com.au/Find everything Mat is doing at https://linktr.ee/matmclachlanFor more history: https://www.LivingHistoryTV.com Hosted on Acast. See acast.com/privacy for more information.

In this week's episode we'll learn about targeting NPM1 in acute myeloid leukemia. Researchers report the first clinical evidence of a menin inhibitor inducing complete remissions in AML with a NPM1 mutation. This validates NPM1 as a new therapeutic target in AML, alongside FLT3, IDH1/2, and KMT2A. Also on the podcast: targeting CD137 to prevent graft-versus-host disease. In nonhuman primates, a single dose of a CD137 antibody-drug conjugate provided long-term protection, with one important caveat: the potential for viral reactivation.Featured Articles: Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 studyA single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/WFS865. CME credit will be available until August 21, 2026.All Rise for Innovation in AML: Processing New Developments With Menin Inhibitors in Challenging AML Subtypes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/WFS865. CME credit will be available until August 21, 2026.All Rise for Innovation in AML: Processing New Developments With Menin Inhibitors in Challenging AML Subtypes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

In this episode, we took a deep dive intro the landscape of menin inhibitors in AML with Dr. Eytan Stein from MSKCC. Here are the key trials and studies we discussed: ELN 2022 AML Classification https://ashpublications.org/blood/article/140/12/1345/485817/Diagnosis-and-management-of-AML-in-adults-2022Predictors of outcomes in adults with AML and KMT2A rearrangements: https://www.nature.com/articles/s41408-021-00557-6DOT1L inhibitor https://ashpublications.org/blood/article/131/24/2661/37193/The-DOT1L-inhibitor-pinometostat-reduces-H3K79AUGMENT 101: https://ascopubs.org/doi/10.1200/JCO.24.00826Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study: https://ashpublications.org/blood/article/doi/10.1182/blood.2025028357/537139/Menin-inhibition-with-revumenib-for-NPM1-mutatedKOMET-001: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(24)00386-3/abstractSAVE trial: https://ashpublications.org/blood/article/144/Supplement%201/216/530724/Phase-I-II-Study-of-the-All-Oral-Combination-ofKOMET-007: https://library.ehaweb.org/eha/2025/eha2025-congress/4159213/harry.erba.ziftomenib.combined.with.intensive.induction.chemotherapy.2872B329.in.html?f=menu%3D6%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D3%2Ace_id%3D2882%2Aot_id%3D31560%2Amarker%3D5843%2Afeatured%3D19595MEN1 mutations: https://www.nature.com/articles/s41586-023-05755-9 

Continuing our journeys along the roads which crisscross the landscape of the Western Front, we travel to Flanders in Belgium, and take the old Roman road between the city of Ypres and the town of Menin which follows the story of four years of conflict here in the First World War and discuss once more the 'culture' of The Old Front Line.Got a question about this episode or any others? Drop your question into the Old Front Line Discord Server or email the podcast.Send us a textSupport the show