Podcasts about nrx

Hans-Herman Hoppe is a German-born economist of the Austrian School, an anarcho-capitalist, professor emeritus of economics at the University of Nevada and, as the title of this book would suggest, not a democracy enjoyer.Considered a seminal work by, among others, NRx luminaries such as Mencious Moldbug and Nick Land, Democracy: The God That Failed offers a praxeological justification for why all states are bad, but democracies are worse than monarchies.For this episode, we were lucky to be joined by Gabe Sinclair of the Tooky's Mag Side Bar podcast, a grotesquely well-read Spenglermale and internet critter who can be found on Twitter as @EzraRunnaroundTooky's Mag: https://tookys.substack.com/Gabe on Twitter: @EzraRunnaroundVERY IMPORTANT INFORMATIONJack has published a novel called Tower!Amazon: https://www.amazon.com/Tower-Jack-BC-ebook/dp/B0CM5P9N9M/ref=monarch_sidesheetThe first nine chapters of Tower are available for free here: jackbc.substack.comOur Patreon: www.patreon.com/TheBookClubfromHellJack's Substack: jackbc.substack.comLevi's website: www.levioutloud.comwww.thebookclubfromhell.comJoin our Discord (the best place to interact with us): discord.gg/ZMtDJ9HscrWatch us on YouTube: https://www.youtube.com/channel/UC0n7r1ZTpsUw5exoYxb4aKA/featuredX: @bookclubhell666Jack on X: @supersquat1Levi on X: @optimismlevi

1. Indignados con Triple S médicos y otros proveedore por destacar a una enemiga de esos profesionales como directora de su Fundación 2. Peligra acreditación de la Oficina del Comisionado de Seguros 3. Eliezer Molina denuncia que están botando papeletas con su nombre. Molina reaccionó al video que circulé en mis plataformas de la ciudadana Wanda González quien reportó que, en la Comisión Estatal de Elecciones, se están desapareciendo papeletas 4. Auditoría revela precario panorama en el pago de las deudas del gobierno 5. Tres frases de Lolita Lebrón ante el machismo 6. En el día contra la violencia a la mujer, urgen más servicios de apoyo a las víctimas de agresión sexual en Puerto Rico 7. Hoy a las 5 PM, la Colectiva Feminista en Construcción convoca manifestación y espacio de encuentro entre mujeres y feministas, en conmemoración de Día de no más violencia contras las mujeres en el Atrio central, Plaza Las Américas “Queremos que este fogueo sirva de espacio de calentamiento, para juntar fuerzas, energías y voluntades entre las feministas militantes en el país”, dicen. 8. La Policía es responsable. El viernes los comerciantes de Piñones denunciaron temor por la criminal ya que la Policía cerró el cuartel de su zona y mandó a los dos oficiales al pueblo, dejando sin protección toda la zona turística. Ayer hubo un tiroteo en negocio de Piñones que cobró la vida de un comerciante. 9. Glenn Monroig estuvo apoteósico. No hay palabras para describir su grandeza. 10. NRx: el movimiento (subterráneo) que quiere cargarse la democracia Estas son algunas de las noticias que tenemos hoy En Blanco y Negro con Sandra. AUDIO: Este es un programa independiente y sindicalizado. Esto significa que se transmite simultáneamente por una serie de emisoras de radio y medios que son los más fuertes en sus respectivas regiones, por sus plataformas digitales, aplicaciones para dispositivos móviles y redes sociales. Estos medios son: 1. Cadena WIAC - WYAC 930 AM Cabo Rojo- Mayagüez 2. Cadena WIAC – WISA 1390 AM Isabela 3. Cadena WIAC – WIAC 740 AM Área norte y zona metropolitana 4. WLRP 1460 AM Radio Raíces La voz del Pepino en San Sebastián 5. X61 – 610 AM en Patillas 6. X61 – 94.3 FM Patillas y todo el sureste 7. WPAB 550 AM - Ponce 8. ECO 93.1 FM – En todo Puerto Rico 9. Mundo Latino PR.com Podcast disponible en Spotify, Soundcloud, Apple Podcasts, Google Podcasts y otras plataformas https://anchor.fm/sandrarodriguezcotto También nos pueden seguir en: REDES SOCIALES: Facebook, X (Twitter), Instagram, Threads, LinkedIn, Tumblr, TikTok BLOG: En Blanco y Negro con Sandra http://enblancoynegromedia.blogspot.com SUSCRIPCIÓN: Substack, plataforma de suscripción de prensa independiente https://substack.com/@sandrarodriguezcotto OTROS MEDIOS DIGITALES: ¡Ey! Boricua, Revista Seguros. Revista Crónicas y otros --- Support this podcast: https://podcasters.spotify.com/pod/show/sandrarodriguezcotto/support

In this episode of The International Risk Podcast, Roger Burrows and Dominic discuss the upcoming US Elections. They discuss the consequences of the influence of NRx on Republicans and extremist viewpoints that have been shared throughout the election process. Moreover, Roger gives us his view on the three most important risks that we are facing as a society. Tune in to find out which!Roger Burrows is Professor in Global Inequalities in the School of Policy Studies at the University of Bristol, UK and Honorary Professorial Fellow at the Centre for Cities at the University of Melbourne, Australia. His most recent research has been on the social impacts of the global superrich and, more recently, the role of digital risk profiling technologies in housing markets. His writings on NRx include Smith, H. and Burrows, R. (2021) 'Software, Sovereignty and the post-neoliberal Politics of Exit'.The International Risk Podcast is a weekly podcast for senior executives, board members, and risk advisors. In these podcasts, we speak with experts in a variety of fields to explore international relations. Our host is Dominic Bowen, Head of Strategic Advisory at one of Europe's leading risk consulting firms. Dominic is a regular public and corporate event speaker, and visiting lecturer at several universities. Having spent the last 20 years successfully establishing large and complex operations in the world's highest-risk areas and conflict zones, Dominic now joins you to speak with exciting guests around the world to discuss international risk.The International Risk Podcast – Reducing risk by increasing knowledge.Follow us on LinkedIn for all our great updates.

For the AMA Style cheat sheet learnamastyle.com See the full write ups for today's episode at nascentmc.com/podcast Here are the highlights:  Test for Risk of Opioid Addiction:The FDA has approved AvertD by SOLVD Health, a test for assessing opioid addiction risk in individuals over 18, using genetic variants to evaluate addiction risk before prescribing oral opioids for acute pain; however, it's met with skepticism and not intended for chronic pain patients. https://www.cnn.com/2023/12/20/health/opioid-use-disorder-test-avertd/index.html https://avertdtest.com/  Filsuvez for Junctional Epidermolysis Bullosa:Filsuvez, a birch triterpenes topical gel, received FDA approval for treating Junctional and Dystrophic Epidermolysis Bullosa (JEB/DEB) in individuals aged 6 months and older, marking the first FDA-approved therapy for JEB's partial thickness wounds and a significant advancement in managing this debilitating skin disorder.https://resources.chiesiusa.com/Filsuvez/FILSUVEZ_PI.pdf Budesonide for IgA Nephropathy:Budesonide (Tarpeyo) received full FDA approval for reducing kidney function loss in adults with IgA nephropathy (IgAN), targeting specific antibodies implicated in IgAN based on phase 3 NefIgArd clinical trial data, marking the first FDA approval for IgAN treatment based on kidney function measures. https://www.tarpeyo.com/prescribinginformation.pdf Eplontersen for hATTR Polyneuropathy:Eplontersen (Wainua) was approved by the FDA for treating polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR-PN), based on the NEURO-TTRansform Phase III trial, and is the only hATTR-PN treatment that can be self-administered via an auto-injector. https://pubmed.ncbi.nlm.nih.gov/37768671/ https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217388s000lbl.pdf NRX-101 for Complicated UTI:The FDA cleared an Investigational New Drug application for NRX-101, a D-cycloserine and lurasidone blend developed by NRx Pharmaceuticals for treating complicated urinary tract infections, with a pending request for Qualified Infectious Disease Product designation. https://www.prnewswire.com/news-releases/nrx-pharmaceuticals-announces-fda-clearance-of-its-investigational-new-drug-ind-application-for-nrx-101-in-the-treatment-of-complicated-urinary-tract-infections-302017523.html?utm_source=pocket_saves Gefapixant for Chronic Cough:Merck's gefapixant, a selective antagonist of P2X3 receptors for treating chronic cough, was rejected by the FDA for the second time due to insufficient evidence of effectiveness in treating refractory or unexplained chronic cough in adults. https://www.businesswire.com/news/home/20231220302305/en/Merck-Provides-U.S.-Regulatory-Update-on-Gefapixant V116 for Invasive Pneumococcal Disease:Merck's V116, a 21-valent pneumococcal conjugate vaccine, was accepted by the FDA for priority review to prevent invasive pneumococcal disease in adults, based on STRIDE-3 Phase 3 trial data, with a target action date set for June 17, 2024. https://www.merck.com/news/fda-grants-priority-review-to-mercks-new-biologics-license-application-for-v116-an-investigational-21-valent-pneumococcal-conjugate-vaccine-specifically-designed-to-protect-adults Sotorasib in NSCLC:Lumakras (sotorasib), already under accelerated approval for KRASG12C-mutated non-small cell lung cancer (NSCLC), faces uncertainty for full FDA approval after an advisory committee voted against it, though it will remain available for clinical use.https://www.onclive.com/view/codebreak-200-sotorasib-in-second-line-kras-g12c-mutated-nsclc nascentmc.comlearnAMAstyle.com

NRx Pharmaceuticals Founder Chief Scientist Dr Jonathan Javitt joined Steve Darling from Proactive to discusses groundbreaking developments in treating suicidal ideation and depression. NRX focuses on targeting the NMDA receptor in the brain, identified as crucial for turning off suicidal thoughts. Traditional antidepressants, which target the serotonin axis, often increase suicide risk, highlighting the need for a new approach. Javitt told Proactive the company is approaching the clinical trial enrollment goals for its partnered product NRX-101, while opening new clinical initiatives in chronic pain, urinary tract infection, and NRX-100 for suicidal depression. The company says the trial is near completion of enrollment of the originally-targeted 70 participants in the Phase 2b/3 trial of NRX-101. Top-line data from this cohort of patients is expected shortly after the last patient visit. Javitt told Proactive Chronic pain affects more than 50 million American adults, compared to the approximately 3 million who report thoughts of suicide on an annual basis. There has been no new non-opioid class of drugs to treat nociceptive pain in the past two decades and NRX-101 has the potential to be the first N-methyl-D-aspartate-antagonist drug to seek approval for this indication. #proactiveinvestors #nrxpharmaceuticalsinc #nasdaq #nrxp #SuicidePrevention #DepressionTreatment #NRXPharmaceuticals #InnovationInHealthcare #BrainHealth #MedicalBreakthroughs #NMDAReceptor #KetamineTherapy #BipolarDepression #FDAApproval #ChronicPainRelief #Antidepressant #HealthcareInnovation #MedicalResearch #NRX101 #NRX100 #ScientificAdvancements #HopeForPatients #MedicalScience #BreakingBarriers #CureForDepression #PatientAdvocacy #ResearchMilestones #EndingStigma #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

I hosted the great Philosopher Nick Land for a dialogue that's the best had on the show so far. We discuss Hyperagents, Ai, The Enigma of time, Acceleration harnessed for a Caesar's rise, and as a possible return of the mythicNick Land is an illustrious philosopher and father of Acceleration. In the late 1990s he founded the radically experimental CCRU Cultural Cybernetics Research Unit while a professor at Warwick University, where he made discoveries and developed methods that would heavily influence Speculative Realism, Philosophy, and Cognitive Science, decades after the fact. His tech predictions made decades ago continue to come true. Land's underground influence can't be escaped, reverberating through many disciplines and in the arts. Also a father of NRx. Get full access to Scott Mannion's Metalore at scottmannion.substack.com/subscribe

www.goodluckgabe.life    The Perils of Audience Capture How influencers become brainwashed by their audiences The Man Who Ate Himself In 2016, 24 year old Nicholas Perry wanted to be big online. He started uploading videos to his YouTube channel in which he pursued his passion—playing the violin—and extolled the virtues of veganism. He went largely unnoticed.   A year later, he abandoned veganism, citing health concerns. Now free to eat whatever he wanted, he began uploading mukbang videos of himself consuming various dishes while talking to the camera, as if having dinner with a friend.   These new videos quickly found a sizable audience, but as the audience grew, so did their demands. The comments sections of the videos soon became filled with people challenging Perry to eat as much as he physically could. Eager to please, he began to set himself torturous eating challenges, each bigger than the last. His audience applauded, but always demanded more. Soon, he was filming himself eating entire menus of fast food restaurants in one sitting.   In some respects, all his eating paid off; Nikocado Avocado, as Perry is now better known, has amassed over six million subscribers across six channels on YouTube. By satisfying the escalating demands of his audience, he got his wish of blowing up and being big online. But the cost was that he blew up and became big in ways he hadn't anticipated. Top: Nicholas Perry when he first started making mukbang videos. Bottom: Perry transformed by his audience's desires into Nikocado. Nikocado, moulded by his audience's desires into a cartoonish extreme, is now a wholly different character from Nicholas Perry, the vegan violinist who first started making videos. Where Perry was mild-mannered and health conscious, Nikocado is loud, abrasive, and spectacularly grotesque. Where Perry was a picky eater, Nikocado devoured everything he could, including finally Perry himself. The rampant appetite for attention caused the person to be subsumed by the persona.   We often talk of "captive audiences," regarding the performer as hypnotizing their viewers. But just as often, it's the viewers hypnotizing the performer. This disease, of which Perry is but one victim of many, is known as audience capture, and it's essential to understanding influencers in particular and the online ecosystem in general.   Lost in the Looking Glass Audience capture is an irresistible force in the world of influencing, because it's not just a conscious process but also an unconscious one. While it may ostensibly appear to be a simple case of influencers making a business decision to create more of the content they believe audiences want, and then being incentivized by engagement numbers to remain in this niche forever, it's actually deeper than that. It involves the gradual and unwitting replacement of a person's identity with one custom-made for the audience.   To understand how, we must consider how people come to define themselves. A person's identity is being constantly refined, so it needs constant feedback. That feedback typically comes from other people, not so much by what they say they see as by what we think they see. We develop our personalities by imagining ourselves through others' eyes, using their borrowed gazes like mirrors to dress ourselves.   Just as lacking a mirror to dress ourselves leaves us disheveled, so lacking other people's eyes to refine our personalities leaves us uncouth. This is why those raised in isolation, like poor Genie, become feral humans, adopting the character of beasts.   Put simply, in order to be someone, we need someone to be someone for. Our personalities develop as a role we perform for other people, fulfilling the expectations we think they have of us. The American sociologist Charles Cooley dubbed this phenomenon “the looking glass self.” Evidence for it is diverse, and includes the everyday experience of seeing ourselves through imagined eyes in social situations (the spotlight effect), the tendency for people to alter their behavior when in the presence of pictures of eyes (the watching-eye effect), and the tendency for people in virtual spaces to adopt the traits of their avatars in an attempt to fulfill expectations (the Proteus effect).   When we lived in small tight-knit communities, the looking glass self helped us to become the people our loved ones needed us to be. The “Michelangelo phenomenon” is the name given to the semi-conscious cycle of refinement and feedback whereby lovers who genuinely care what each other think gradually grow closer to their partner's original ideal of them.   The problem is, we no longer live solely among those we know well. We're now forced to refine our personalities by the countless eyes of strangers. And this has begun to affect the process by which we develop our identities.   Gradually we're all gaining online audiences, and we don't really know these people. We can only gauge who they are by what some of them post online, and what people post online is not indicative of who they really are. As such, the people we're increasingly becoming someone for are an abstract illusion.   When influencers are analyzing audience feedback, they often find that their more outlandish behavior receives the most attention and approval, which leads them to recalibrate their personalities according to far more extreme social cues than those they'd receive in real life. In doing this they exaggerate the more idiosyncratic facets of their personalities, becoming crude caricatures of themselves.   The caricature quickly becomes the influencer's distinct brand, and all subsequent attempts by the influencer to remain on-brand and fulfill audience expectations require them to act like the caricature. As the caricature becomes more familiar than the person, both to the audience and to the influencer, it comes to be regarded by both as the only honest expression of the influencer, so that any deviation from it soon looks and feels inauthentic. At that point the persona has eclipsed the person, and the audience has captured the influencer.   The old Greek legends tell of Narcissus, a youth so handsome he became besotted by his own reflection. Unable to look away from his image in the surface of the waters, he fell still forever, and was transformed by the gods into a flower. Similarly, as influencers glimpse their idealized online personas reflected back at them on screens, they too are in danger of becoming eternally besotted by how they appear, and in so doing, forgetting who they were, or could be.   III. The Prostitution of the Intellect Audience capture is a particular problem in politics, due to both phenomena being driven by popular approval. On Twitter I've watched many political influencers gradually become radicalized by their audiences, starting off moderate but following their increasingly extreme followers toward the fringes.   One example is Louise Mensch, a once-respectable journalist and former Conservative politician who in 2016 published a story about Trump's alleged ties to Russia, which went viral. She subsequently gained a huge audience of #NotMyPresident #Resist types, and, encouraged by her new, indignant audience to uncover more evidence of Trump's corruption, she appears to have begun to view herself as the one who'd prove Russiagate and bring down the Donald. The immense responsibility she felt to her audience seems to have motivated her to see dramatic patterns in pure noise, and to concoct increasingly speculative conspiracy theories about Trump and Russia, such as the claim that Vladimir Putin assassinated Andrew Breitbart, the founder of Breitbart News, so his job would go to Trump ally Steve Bannon. When her former allies, such as the hacker known as "the Jester," expressed concern over her new trajectory toward fringe theories, she doubled down, accusing all her critics of being Trump shills or Putin shills.   Another, more recent victim of audience capture is Maajid Nawaz. I've always liked Maajid, and as someone who once worked with the organization he founded, the counter terrorism think-tank Quilliam, I'm aware of how careful and considered he can be. Unfortunately, since the pandemic, he's been different. His descent began with him posting a few vague theories about the virus being a fraud perpetrated on an unsuspecting public, and after his posts went viral he found himself being inundated with new "Covid-skeptic" followers, who showered him with new leads to chase.   In January, after he lost his position at the radio show LBC due to his increasingly careless theories about a secretive New World Order, he implied his firing was part of the conspiracy to silence the truth, and urged his loyal followers to subscribe to his Substack, as this was now his family's only source of income. His new audience proved to be generous with both money and attention, and his need to meet their expectations seems to have spurred him, consciously or unconsciously, to double down on his more extreme views. Now almost everything he writes about, from Covid to Ukraine, he somehow ties to the shadowy New World Order.   Motivated by his audience to continually uncover new truths about the conspiracy, Maajid has been forced to scrape the barrel of claims. His recent work is his wildest yet, combining common tropes like resurrected Nazi eugenics programs, satanic rituals, and the Bilderberg meeting. Among the fields he now relies on for his evidence are... numerology.   Twitter avatar for @MaajidNawaz Maajid أبو عمّار  @MaajidNawaz British MPs have begun voting on a motion of ‘no confidence' in the UK Parliament against Prime Minister Johnson.    The vote commenced at:   6pm, on the 6th day, of the 6th month.    No joke.    آل عمران:[54] وَمَكَرُوا وَمَكَرَ اللَّهُ وَاللَّهُ خَيْرُ الْمَاكِرِينَ  Twitter avatar for @MaajidNawaz Maajid أبو عمّار  @MaajidNawaz 3 of our British MPs were at this dodgy af global Bilderberg meeting:   Michael Gove (con) Tom Tugendhat (con) David Lammy (lab)   Their attendance alone must be remembered if they ever seek leadership of their respective political parties and hence try to become PM of Britain https://t.co/EKohVzfaiN 6:52 PM ∙ Jun 6, 2022 957 Likes 287 Retweets There is clear value in investigating the corruption that pervades the misty pinnacles of power, but by defining himself by his audience's view of him as the uncoverer of a global conspiracy, Maajid has ensured he'll see evidence of the conspiracy in all things. Instead of performing real investigation, he is now merely playing the role of investigator for his audience, a role that requires drama rather than diligence, and which can lead only to his audience's desired conclusions.   Muddying the Waters to Obscure the Reflection Maajid, Mensch, and Perry are far from the only victims of audience capture. Given how fundamental the looking glass self is to the development of our personalities, every influencer has likely been affected by it to some degree. And that includes me.   I'm no authority on the degree to which my mind has been captured by you, my audience. But I do suspect that audience capture affects me far less than most influencers because I've taken specific steps to avoid it. I was aware of the pitfall long before I became an influencer. I wanted an audience, but I also knew that having the wrong audience would be worse than having no audience, because they'd constrain me with their expectations, forcing me to focus on one tiny niche of my worldview at the expense of everything else, until I became a parody of myself.   It was clear to me that the only way to resist becoming what other people wanted me to be was to have a strong sense of who I wanted to be. And who I wanted to be was someone immune to audience capture, someone who thinks his own thoughts, decides his own destiny, and above all, never stops growing.   I knew there were limits to my desired independence, because, whether we like it or not, we all become like the people we surround ourselves with. So I surrounded myself with the people I wanted to be like. On Twitter I cultivated a reasonable, open-minded audience by posting reasonable, open-minded tweets. The biggest jumps in my follower count came from my megathreads of mental models, which cover so many topics from so many perspectives that the people who appreciated them enough to follow me would need to be willing to consider new perspectives. Naturally these people came to view me as, and expected me to be, an independent thinker as open to learning and growing as themselves.   In this way I ensured that my brand image—the person that my audience expects me to be—was in alignment with my ideal image—the person I want to be. So even though audience capture likely does affect me in some way, it only makes me more like the person I want to be. I hacked the system.   My brand image is, admittedly, diffuse and weak. My Twitter bio is “saboteur of narratives,” and few people can say for sure what I'm about, other than vague things like “thinker” or “dumb fuck.” And that's how I like it. My vagueness makes me hard to pigeonhole, predict, and capture.   For this same reason, I'm suspicious of those with strong, sharply delineated brands. Human beings are capricious and largely formless storms of idiosyncrasies, so a human only develops a clear and distinct identity through the artifice of performance.   Nikocado has a clear and distinct identity, but its clarity and distinctness make it hard to escape. He may be a millionaire with legions of fans, but his videos, filled with complaints-disguised-as-jokes about his poor health, hardly make him seem happy.   Unfortunately, salvation seems out of reach for him because his audience, or at least the audience he imagines, demands he be the same as he was yesterday. And even if he were to find the strength to break character and be himself again, he's been acting for so long that stopping would only make him feel like an imposter.   This is the ultimate trapdoor in the hall of fame; to become a prisoner of one's own persona. The desire for recognition in an increasingly atomized world lures us to be who strangers wish us to be. And with personal development so arduous and lonely, there is ease and comfort in crowdsourcing your identity. But amid such temptations, it's worth remembering that when you become who your audience expects at the expense of who you are, the affection you receive is not intended for you but for the character you're playing, a character you'll eventually tire of. So the next time you find yourself in the limelight of other people's gazes, remember that being someone often means being fake, and if you chase the approval of others, you may, in the end, lose the approval of yourself TikTok is a Time Bomb The ultimate weapon of mass distraction   For thousands of years, humans sought to subjugate their enemies by inflicting pain, misery, and terror. They did this because these were the most paralyzing emotions they could consistently evoke; all it took was the slash of a sword or pull of a trigger. But as our understanding of psychology has developed, so it has become easier to evoke other emotions in complete strangers. Advances in the understanding of positive reinforcement, driven mostly by people trying to get us to click on links, have now made it possible to consistently give people on the other side of the world dopamine hits at scale. As such, pleasure is now a weapon; a way to incapacitate an enemy as surely as does pain. And the first pleasure-weapon of mass destruction may just be a little app on your phone called TikTok. I. The Smiling Tiger TikTok is the most successful app in history. It emerged in 2017 out of the Chinese video-sharing app Douyin and within three years it had become the most downloaded app in the world, later surpassing Google as the world's most visited web domain. TikTok's conquest of human attention was facilitated by the covid lockdowns of 2020, but its success wasn't mere luck. There's something about the design of the app that makes it unusually irresistible. Other platforms, like Facebook and Twitter, use recommendation algorithms as features to enhance the core product. With TikTok, the recommendation algorithm is the core product. You don't need to form a social network or list your interests for the platform to begin tailoring content to your desires, you just start watching, skipping any videos that don't immediately draw your interest. Tiktok uses a proprietary algorithm, known simply as the For You algorithm, that uses machine learning to build a personality profile of you by training itself on your watch habits (and possibly your facial expressions.) Since a TikTok video is generally much shorter than, say, a YouTube video, the algorithm acquires training data from you at a much faster rate, allowing it to quickly zero in on you. The result is a system that's unsurpassed at figuring you out. And once it's figured you out, it can then show you what it needs to in order to addict you. Since the For You algorithm favors only the most instantly mesmerizing content, its constructive videos—such as “how to” guides and field journalism—tend to be relegated to the fringes in favor of tasty but malignant junk info. Many of the most popular TikTokers, such as Charli D'Amelio, Bella Poarch, and Addison Rae, do little more than vapidly dance and lip-sync. Individually, such videos are harmless, but the algorithm doesn't intend to show you just one. When it receives the signal that it's got your attention, it doubles down on whatever it did to get it. This allows it to feed your obsessions, showing you hypnotic content again and again, reinforcing its imprint on your brain. This content can include promotion of self-harm and eating disorders, and uncritical encouragement of sex-reassignment surgery. There's evidence that watching such content can cause mass psychogenic illness: researchers recently identified a new phenomenon where otherwise healthy young girls who watched clips of Tourette's sufferers developed Tourette's-like tics. A more common way TikTok promotes irrational behavior is with viral trends and “challenges,” where people engage in a specific act of idiocy in the hope it'll make them TikTok-famous. Acts include licking toilets, snorting suntan lotion, eating chicken cooked in NyQuil, and stealing cars. One challenge, known as “devious licks”, encourages kids to vandalize property, while the “blackout challenge,” in which kids purposefully choke themselves with household items, has even led to several deaths, including a little girl a few days ago.   As troublesome as TikTok's trends are, the app's greatest danger lies not in any specific content but in its general addictive nature. Studies on long term TikTok addiction don't yet exist for obvious reasons, but, based on what we know of internet addiction generally, we can extrapolate its eventual effects on habitual TikTokers. There's a substantial body of research showing a strong association between smartphone addiction, shrinkage of the brain's gray matter, and “digital dementia,” an umbrella term for the onset of anxiety and depression and the deterioration of memory, attention span, self-esteem, and impulse control (the last of which increases the addiction). These are the problems caused by internet addiction generally. But there's something about TikTok that makes it uniquely dangerous. In order to develop and maintain mental faculties like memory and attention span, one needs to practice using them. TikTok, more than any other app, is designed to give you what you want while requiring you to do as little as possible. It cares little who you follow or what buttons you click; its main consideration is how long you spend watching. Its reliance on machine learning rather than user input, combined with the fact that TikTok clips are so short they require minimal memory and attention span, makes browsing TikTok the most passive, uninteractive experience of all major platforms. If it's the passive nature of online content consumption that causes atrophy of mental faculties, then TikTok, as the most passively used platform, will naturally cause the most atrophy. Indeed many habitual TikTokers can already be found complaining on websites like Reddit about their loss of mental ability, a phenomenon that's come to be known as “TikTok brain.” If the signs are becoming apparent already, imagine what TikTok addiction will have done to young developing brains a decade from now. TikTok's capacity to stupefy people, both acutely by encouraging idiotic behavior, and chronically by atrophying the brain, should prompt consideration of its potential use as a new kind of weapon, one that seeks to neutralize enemies not by inflicting pain and terror, but by inflicting pleasure. Last month FBI Director Chris Wray warned that TikTok is controlled by a Chinese government that could “use it for influence operations.” So how likely is it that one such influence operation might include addicting young Westerners to mind-numbing content to create a generation of nincompoops? The first indication that the Chinese Communist Party is aware of TikTok's malign influence on kids is that it's forbidden access of the app to Chinese kids. The American tech ethicist Tristan Harris pointed out that the Chinese version of TikTok, Douyin, is a “spinach” version where kids don't see twerkers and toilet-lickers but science experiments and educational videos. Furthermore, Douyin is only accessible to kids for 40 minutes per day, and it cannot be accessed between 10pm and 6am. Has the CCP enforced such rules to protect its people from what it intends to inflict on the West? When one examines the philosophical doctrines behind the rules, it becomes clear that the CCP doesn't just believe that apps like TikTok make people stupid, but that they destroy civilizations. II. Seven Mouths, Eight Tongues China has been suspicious of Western liberal capitalism since the 1800s, when the country's initial openness led to the Western powers flooding China with opium. The epidemic of addiction, combined with the ensuing Opium Wars, accelerated the fall of the Qing Dynasty and led to the Century of Humiliation in which China was subject to harsh and unequal terms by Britain and the US. Mao is credited with eventually crushing the opium epidemic, and since then the view among many in China has been that Western liberalism leads to decadence and that authoritarianism is the cure. But one man has done more than anyone to turn this thesis into policy. His name is Wang Huning, and, despite not being well known outside China, he has been China's top ideological theorist for three decades, and he is now member number 4 of the seven-man Standing Committee—China's most powerful body. He advised China's former leaders Jiang Zemin and Hu Jintao, and now he advises Xi Jinping, authoring many of his policies. In China he is called “guoshi” (国师: literally, “teacher of the nation”).   Wang refuses to do press or to even speak with foreigners, but his worldview can be surmised from the books he wrote earlier in his life. In August 1988, Wang accepted an invitation to spend six months in the US, and traveled from state to state noting the way American society operates, examining its strengths and weaknesses. He recorded his findings in the 1991 book, America Against America, which has since become a key CCP text for understanding the US. The premise of the book is simple: the US is a paradox composed of contradictions: its two primary values—freedom and equality—are mutually exclusive. It has many different cultures, and therefore no overall culture. And its market-driven society has given it economic riches but spiritual poverty. As he writes in the book, “American institutions, culture and values oppose the United States itself.” For Wang, the US's contradictions stem from one source: nihilism. The country has become severed from its traditions and is so individualistic it can't make up its mind what it as a nation believes. Without an overarching culture maintaining its values, the government's regulatory powers are weak, easily corrupted by lobbying or paralyzed by partisan bickering. As such, the nation's progress is directed mostly by blind market forces; it obeys not a single command but a cacophony of three hundred million demands that lead it everywhere and nowhere. In Wang's view, the lack of a unifying culture puts a hard limit on the US's progress. The country is constantly producing wondrous new technologies, but these technologies have no guiding purpose other than their own proliferation. The result is that all technological advancement leads the US along one unfortunate trajectory: toward more and more commodification. Wang writes: “Human flesh, sex, knowledge, politics, power, and law can all become the target of commodification… Commodification, in many ways, corrupts society and leads to a number of serious social problems. These problems, in turn, can increase the pressure on the political and administrative system.” Thus, by turning everything into a product, Western capitalism devours every aspect of American culture, including the traditions that bind it together as a nation, leading to atomization and polarization. The commodification also devours meaning and purpose, and to plug the expanding spiritual hole that this leaves, Americans turn to momentary pleasures—drugs, fast food, and amusements—driving the nation further into decadence and decay. For Wang, then, the US's unprecedented technological progress is leading it into a chasm. Every new microchip, TV, and automobile only distracts and sedates Americans further. As Wang writes in his book, “it is not the people who master the technology, but the technology that masters the people.” Though these words are 30 years old, they could easily have been talking about social media addiction. Wang theorized that the conflict between the US's economic system and its value system made it fundamentally unstable and destined for ever more commodification, nihilism, and decadence, until it finally collapses under the weight of its own contradictions. To prevent China's own technological advancement leading it down the same perilous path, Wang proposed an extreme solution: neo-authoritarianism. In his 1988 essay, “The Structure of China's Changing Political Culture,” Wang wrote that the only way a nation can avoid the US's problems is by instilling “core values”—a national consensus of beliefs and principles rooted in the traditions of the past and directed toward a clear goal in the future. Such a consensus could eventually ward off nihilism and decadence, but cultivating it would in turn require the elimination of nihilism and decadence. This idea has been central to President Xi's governance strategy, which has emphasized “core socialist values” like civility, patriotism, and integrity. So how has the push for these socialist core values affected the CCP's approach to social media? The creator of TikTok and CEO of Bytedance, Zhang Yiming, originally intended for the content on TikTok and its Chinese version, Douyin, to be determined purely by popularity. As such, Douyin started off much like TikTok is now, with the content dominated by teenagers singing and dancing. In April 2018, the CCP began action against Zhang. Its media watchdog, the National Radio and Television Administration, ordered the removal from Chinese app stores of Bytedance's then-most popular app, Toutiao, and its AI news aggregator, Neihan Duanzi, citing their platforming of “improper” content. Zhang then took to social media to offer a groveling public apology, stating: "Our products took the wrong path, and content appeared that was incommensurate with socialist core values." Shortly after, Bytedance announced it would recruit thousands more people to moderate content, and, according to CNN, in the subsequent job ads it stated a preference for CCP members with “strong political sensitivity.” The CCP's influence over Bytedance has only grown since then. Last year, the Party acquired a “golden share” in Bytedance's Beijing entity, and one of its officials, Wu Shugang, took one of the company's three board seats. The CCP's intrusion into Bytedance's operations is part of a broader strategy by Xi, called the “Profound Transformation”, which seeks to clear space for the instituting of core socialist values by ridding China of “decadent” online content. In August 2021, a statement appeared across Chinese state media calling for an end to TikTok-style “tittytainment” for fear that “our young people will lose their strong and masculine vibes and we will collapse.” In the wake of that statement, there have been crackdowns on “sissy-men” fashions, “digital drugs” like online gaming, and “toxic idol worship.” Consequently, many online influencers have been forcibly deprived of their influence, with some, such as the movie star Zhao Wei, having their entire presence erased from the Chinse web. For Xi and the CCP, eliminating “decadent” TikTok-style content from China is a matter of survival, because such content is considered a herald of nihilism, a regression of humans back to beasts, a symptom of the West's terminal illness that must be prevented from metastasizing to China. And yet, while cracking down on this content domestically, China has continued to allow its export internationally as part of Xi's “digital Silk Road” (数字丝绸之路). TikTok is known to censor content that displeases Beijing, such as mentions of Falun Gong or Tiananmen Square, but otherwise it has free rein to show Westerners what it wants; “tittytainment” and “sissy men” are everywhere on the app. So why the hypocritical disparity in rules? Is the digital Silk Road intended as poetic justice for the original Silk Road, whereby the Western powers preached Christian values while trafficking chemical TikTok—opium—into China? Since Wang and Xi believe the West is too decadent to survive, they may have opted to take the Taoist path of wu wei (無為), which is to say, sit back and let the West's appetites take it where they will. But there's another, more sinister and effective approach they may have adopted. To understand it, we must consider one final piece of the puzzle: an amphetamine-fueled philosopher who lived in my hometown. III. The Matricide Laboratory At first glance the British philosopher Nick Land could hardly be more different from Wang Huning. Wang rose to prominence by being dour, discreet, and composed, while Land rose to prominence by ranting about cyborg apocalypses while out of his mind on weed and speed. In the late 1990s Land moved into a house once owned by the Satanist libertine Aleister Crowley (half a mile from where I grew up), and there he apparently binged on drugs and scrawled occult diagrams on the walls. At nearby Warwick University where he taught, his lectures were often bizarre (one infamous “lesson” consisted of Land lying on the floor, croaking into a mic, while frenetic jungle music pulsed in the background.)   Land and Wang were not just polar opposites in personality; they also operated at opposite ends of the political spectrum. While Wang would go on to be the top ideological theorist of the Chinese Communist Party, Land would become the top theorist (with Curtis Yarvin) of the influential network of far-right bloggers, NRx. And yet, despite their opposite natures, Land and Wang would develop almost identical visions of liberal capitalism as an all-commodifying, all devouring force, driven by the insatiable hunger of blind market forces, and destined to finally eat Western civilization itself. Land viewed Western liberal capitalism as a kind of AI that's reached the singularity; in other words, an AI that's grown beyond the control of humans and is now unstoppably accelerating toward inhuman ends. As Land feverishly wrote in his 1995 essay, “Meltdown:” “The story goes like this: Earth is captured by a technocapital singularity as renaissance rationalitization and oceanic navigation lock into commoditization take-off. Logistically accelerating techno-economic interactivity crumbles social order in auto-sophisticating machine runaway.” Land's drug-fueled prose is overwrought, so to simplify his point, Western capitalism can be compared to a “paperclip maximizer,” a hypothetical AI programmed by a paperclip business to produce as many paperclips as possible, which leads it to begin recycling everything on earth into paperclips (commodities). When the programmers panic and try to switch it off, the AI turns them into paperclips, since being switched off would stop it fulfilling its goal of creating as many paperclips as possible. Thus, the blind application of short term goals leads to long term ruin. Land believed that, since the runaway AI we call liberal capitalism commodifies everything, including even criticisms of it (which are necessarily published for profit), it cannot be opposed. Every attack on it becomes part of it. Thus, if one wishes to change it, the only way is to accelerate it along its trajectory. As Land stated in a later, more sober writing style: “The point of an analysis of capitalism, or of nihilism, is to do more of it. The process is not to be critiqued. The process is the critique, feeding back into itself, as it escalates. The only way forward is through, which means further in.” —A Quick-and-Dirty Introduction to Accelerationism (2017) This view, that the current system must be accelerated to be transformed, has since become known as “accelerationism.” For Land, acceleration is not just a destructive force but also a creative one; he came to believe that all democracies accelerate toward ruin but a visionary despot unfettered by the concerns of the masses could accelerate a country to prosperity. Land's own life followed the same course he envisioned for the liberal West; following years of high productivity, he fell into nihilism and the decadence of rampant drug use, which drove him to a nervous breakdown. Upon recovering in 2002, he embraced authoritarianism, moved to Shanghai, and began writing for Chinese state media outlets like China Daily and the Shanghai Star. A few years after Land moved to China, talk of accelerationism began to emerge on the Chinese web, where it's become known by its Chinese name, jiasuzhuyi (加速主义). The term has caught on among Chinese democracy advocates, many of whom view the CCP as the runaway AI, hurtling toward greater tyranny; they even refer to Xi as “Accelerator-in-Chief” (总加速师). Domestically, Chinese democracy activists try to accelerate the CCP's authoritarianism ad absurdum; one tactic is to swamp official tip-off lines with reports of minor or made-up infractions, with the intent of breaking the Party by forcing it to enforce all of its own petty rules. As for the CCP itself, it's known to have viewed former US president Donald Trump as the “Accelerator-in-Chief,” or, more accurately, “Chuan Jianguo” (川建国: literally “Build China Trump”) because he was perceived as helping China by accelerating the West's decline. For this reason, support of him was encouraged. The CCP is also known to have engaged in jiasuzhuyi more directly; for instance, during the 2020 US race riots, China used Western social media platforms to douse accelerant over US racial tensions. But the use of TikTok as an accelerant is a whole new scale of accelerationism, one much closer to Land's original, apocalyptic vision. Liberal capitalism is about making people work in order to obtain pleasurable things, and for decades it's been moving toward shortening the delay between desire and gratification, because that's what consumers want. Over the past century the market has taken us toward ever shorter-form entertainment, from cinema in the early 1900s, to TV mid-century, to minutes-long YouTube videos, to seconds-long TikTok clips. With TikTok the delay between desire and gratification is almost instant; there's no longer any patience or effort needed to obtain the reward, so our mental faculties fall into disuse and disrepair. And this is why TikTok could prove such a devastating geopolitical weapon. Slowly but steadily it could turn the West's youth—its future—into perpetually distracted dopamine junkies ill-equipped to maintain the civilization built by their ancestors. We seem to be halfway there already: not only has there been gray matter shrinkage in smartphone-addicted individuals, but, since 1970 the Western average IQ has been steadily falling. Though the decline likely has several causes, it began with the first generation to grow up with widespread TVs in homes, and common sense suggests it's at least partly the result of technology making the attainment of satisfaction increasingly effortless, so that we spend ever more of our time in a passive, vegetative state. If you don't use it, you lose it. And even those still willing to use their brains are at risk of having their efforts foiled by social media, which seems to be affecting not just kids' abilities but also their aspirations; in a survey asking American and Chinese children what job they most wanted, the top answer among Chinese kids was “astronaut,” and the top answer among American kids was “influencer.” If we continue along our present course, the resulting loss of brainpower in key fields could, years from now, begin to harm the West economically. But, more importantly, if it did it would help discredit the very notion of Western liberalism itself, since there is no greater counterargument to a system than to see it destroy itself. And so the CCP would benefit doubly from this outcome: ruin the West and refute it; two birds with one stone (or as they say in China, 箭双雕: one arrow, two eagles.) So, the CCP has both the means and the motive to help the West defeat itself, and part of this could conceivably involve the use of TikTok to accelerate liberal capitalism by closing the gap between desire and gratification. Now, it could be argued that we have no hard evidence of the CCP's intentions, only a set of indications. However, ultimately the CCP's intentions are irrelevant. Accelerationism can't alter an outcome, only hasten it. And TikTok, whether or not it's actively intended as a weapon, is only moving the West further along the course it's long been headed: toward more effortless pleasure, and resulting cognitive decline. The problem, therefore, is not China, but us. America Against America. If TikTok is not a murder weapon, then it's a suicide weapon. China has given the West the means to kill itself, but the death wish is wholly the West's. After all, TikTok dominated our culture as a result of free market forces—the very thing we live by. Land and Wang are correct that the West being controlled by everyone means it's controlled by no one, and without brakes or a steering wheel we're at the market's mercy. Of course, democracies do have some regulatory power. Indian lawmakers banned TikTok in 2020, and US lawmakers are now considering the same. However, while this may stop the theft of our data, it won't stop the theft of our attention; if TikTok is banned then another short-form video site will just take its place. Effortless dopamine hits are what consumers want, and capitalism always tries to give consumers what they want. Anticipating the demand, YouTube has added its own TikTok-style “YouTube Shorts” format, and Twitter recently implemented its own version of TikTok's For You algorithm. The market is a greater accelerator than China could ever hope to be. So what's the solution? Land and Wang may be right about the illness, but they're wrong about the cure. It's true that we in the West have little left of the traditions that once tied us together, and in their absence all that unites us are our animal hungers. But Wang's belief that meaning and purpose can be miraculously imposed on us all by a strongman leader is just a fantasy that has littered history with failed experiments. Sure, democracies are vulnerable because there's no one controlling their advancement, but autocracies are vulnerable precisely for the opposite reason: they're controlled by people, which is to say, by woefully myopic apes. China is currently suffering from the myopia of Xi's zero-covid policy, which has ravaged the country's economy, and from the disastrous one-child policy that's led to China's current population crisis. For all our problems, we'd be unwise to exchange the soft tyranny of dopamine for the hard tyranny of despots. That leaves only one solution: the democratic one. In a democracy responsibility is also democratized, so parents must look out for their own kids. There's a market for this, too: various brands of parental controls can be set on devices to limit kids' access (though many of these, including TikTok's own controls, can be easily bypassed.) But ultimately these are short term measures. In the long term the only way to prevent digital dementia is to raise awareness of the neurological ruin wrought by apps like TikTok, exposing their ugliness so they fall out of fashion like cigarettes. If the weakness of liberalism is its openness, then this is also its strength; word can travel far in democracies. We'll surely sound like alarmists; TikTok destroys so gradually that it seems harmless. But if the app is a time-bomb that'll wreck a whole generation years from now, then we can't wait till its effects are apparent before acting, for then it will be too late. The clock is ticking. Tik. Tok…   I just shit and cum. FAQ What does this mean? The amount of shit (and cum) on my computer and floor has increased by one. Why did you do this? There are several reasons I may deem a comment to be worthy of feces or ejaculation. These include, but are not limited to: Being gay Dank copypasta bro, where'd you find it walter Am I going to shit and cum too? No - not yet. But you should refrain from shitposting and cumposting like this in the future. Otherwise I will be forced to shit and cum again, which may put your shitting and cumming privileges in jeopardy. I don't believe my comment deserved being shit and cum at. Can you un-cum it? Sure, mistakes happen. But only in exceedingly rare circumstances will I put shit back into my butt. If you would like to issue an appeal, shoot me a hot load explaining what I got wrong. I tend to respond to retaliatory ejaculation within several minutes. Do note, however, that over 99.9% of semen dies before it can fertilize the egg, and yours is likely no exception. How can I prevent this from happening in the future? Accept the goopy brown and white substance and move on. But learn from this mistake: your behavior will not be tolerated in my mom's basement. I will continue to shit and cum until you improve your conduct. Remember: ejaculation is privilege, not a right.   I just came in your asshole. I just came in your asshole. FAQ What does this mean? A large load of baby gravy has been transferred from my testicles into your rectum. Why did I do this? There are several reasons why I came in your ass. These include, but are not limited to: Your comment turned me on You are cute Your dad was too busy How did I do this? I rammed your rectum with my handsome hog until I turned you into a frosting factory. Why am I telling you about this? Your ass will be leaking cum for at least 36 hours and may be a slipping hazard. Also you might be gay. How can you avoid this in the future? Unless you stop looking so breedable in the near future, you can't. I will always find a way to fill your tight little boyhole

Curtis Yarvin, also known by the pen name Mencius Moldbug, is an American blogger. He is known, along with philosopher Nick Land, for founding the anti-egalitarian and anti-democratic philosophical movement known as the Dark Enlightenment or neoreactionary movement (NRx). He argues that American democracy is a failed experiment which should be replaced by an accountable monarchy, similar to the governance structure of corporations. SPONSORED BY: Manscaped. Get 20% off and free shipping when you use the code TRIGGER20 at https://www.manscaped.com/ SPONSORED BY: ExpressVPN. Go to https://www.expressvpn.com/trigger/ and get an extra 3 months free on a one-year package! Join our exclusive TRIGGERnometry community on Locals! https://triggernometry.locals.com/ OR Support TRIGGERnometry Here: Bitcoin: bc1qm6vvhduc6s3rvy8u76sllmrfpynfv94qw8p8d5 Music by: Music by: Xentric | info@xentricapc.com | https://www.xentricapc.com/ YouTube:  @xentricapc   Buy Merch Here: https://www.triggerpod.co.uk/shop/ Advertise on TRIGGERnometry: marketing@triggerpod.co.uk Join the Mailing List: https://www.triggerpod.co.uk/sign-up/ Find TRIGGERnometry on Social Media:  https://twitter.com/triggerpod https://www.facebook.com/triggerpod/ https://www.instagram.com/triggerpod/ About TRIGGERnometry:  Stand-up comedians Konstantin Kisin (@konstantinkisin) and Francis Foster (@francisjfoster) make sense of politics, economics, free speech, AI, drug policy and WW3 with the help of presidential advisors, renowned economists, award-winning journalists, controversial writers, leading scientists and notorious comedians.

The International Risk Podcast is a weekly podcast for senior executives, board members and risk advisors. In these podcasts, we speak with risk management specialists from around the world. Our host is Dominic Bowen, one of Europe's leading international risk specialists. Having spent the last 20 years successfully establishing large and complex operations in the world's highest risk areas and conflict zones, Dominic now joins you to speak with exciting guests from around the world to discuss risk.The International Risk Podcast – Reducing risk by increasing knowledgeFollow us on Facebook, Twitter, Instagram, and LinkedIn for all our great updates.This week, Dominic talks with Rodger Burrows. Roger Burrows is Professor in Global Inequalities in the School of Policy Studies at the University of Bristol, UK and Honorary Professorial Fellow at the Centre for Cities at the University of Melbourne, Australia. His most recent research has been on the social impacts of the global superrich and, more recently, the role of digital risk profiling technologies in housing markets. His writings on NRx include Smith, H. and Burrows, R. (2021) 'Software, Sovereignty and the Post-neoliberal Politics of Exit', Theory, Culture & Society, 38, 6:143-166, which is Open Access. 

In this week's episode we'll learn how HLA-E-restricted immune responses help control Epstein-Barr virus infection, discuss the activity of NRX-0492 in chronic lymphoblastic leukemia, and learn more about the efficacy of non-steroid inflammatory drugs in the treatment of bone marrow failure associated with Ghosal Hematodiaphyseal Dysplasia.

On today's episode we review the most expensive rod I've ever bought. Is it worth it? I'll give you my 100% honest opinion as we break down it's sensitivity, balance, price, feel, components, and more! Brought to you by: American Legacy Fishing & Outdoors www.americanlegacyfishing.com Use Code: TACKLETALK10 for 10% Off* Additional Support by: RTIC Coolers & Dakota Lithium

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.28.526024v1?rss=1 Authors: Feller, B., Fallon, A., Luo, W., Nguyen, P. T., Shlaifer, I., Lee, A. K., Karkout, S., Bourgault, S., Durcan, T. M., Takahashi, H. Abstract: Synucleinopathies form a group of neurodegenerative diseases defined by misfolding and aggregation of alpha-synuclein (-syn). Abnormal accumulation and spreading of -syn aggregates lead to synapse dysfunction and neuronal cell death. Yet, little is known about synaptic mechanisms underlying -syn pathology. Here we identified {beta}-isoforms of neurexins ({beta}-NRXs) as presynaptic organizing proteins that interact with -syn preformed fibrils (-syn PFFs), toxic -syn aggregates, but not -syn monomers. Our cell surface protein binding assays and surface plasmon resonance assays reveal that -syn PFFs bind directly to {beta}-NRX through their N-terminal histidine-rich domain (HRD) at nanomolar range (Kd: ~500 nM monomer equivalent). Furthermore, our artificial synapse formation assays show that -syn PFFs diminish excitatory and inhibitory presynaptic organization induced by a specific isoform of neuroligin 1 that binds only {beta}-NRXs, but not -isoforms of neurexins. Thus, our data suggest that -syn PFFs interact with {beta}-NRXs to inhibit {beta}-NRX-mediated presynaptic organization, providing novel molecular insight into how -syn PFFs induce synaptic pathology in synucleinopathies such as Parkinson's disease and dementia with Lewy bodies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

I speak to CA about Twitter's new management and what it means for the regime, biting the bullet on anti-liberalism and charging through the chaos, NRx as a valuable framework, effective altruism, and much more. Covfefe Anon is a Twitter poster @covfefeanon and recent Substack Owner/Operator at Tradeoffs and Conflicts; Institutions and Egregores --- Send in a voice message: https://anchor.fm/aksubversive/message

The NASCAR America Motormouths crew talks about who is running out of time and who is losing their nerves heading into the final Round of 8 race at Martinsville Speedway. Also, Nitro Rallycross founder and driver Travis Pastrana joins the show to talk about the remaining NRX schedule

Engineering News – Imaging Technology for Autonomous Cars (3:20) This week's engineering failure is the Chalk River Nuclear Accidents (11:05). The Chalk River Nuclear Facility north of Ottawa suffered two nuclear accidents in the 1950s. The first with the NRX reactor in 1952 (17:00) and the second with the NRU reactor in 1958 (27:35). Check out our Patreon page for Mini Failure bonus episodes - https://www.patreon.com/failurology Photos/Sources/Summary from this episode - https://www.failurology.ca/ Ways to get in touch Twitter - https://twitter.com/failurology Email - thefailurologypodcast@gmail.com Linked In - https://www.linkedin.com/company/failurology-podcast YouTube - https://www.youtube.com/channel/UCh1Buq46PYyxKbCDGTqbsDg

Lorsqu'on les regarde de loin, les pensées de Guillaume Faye, dépeintes dans l'Archéofuturisme, et celles de Curtis Yarvin et de Nick Land, nommées NRx, développées au fil d'articles, peuvent sembler convergentes. Il semble pourtant que les deux n'aient jamais cultivé de correspondance. Quand on y regarde de plus près, des différences évidentes apparaissent entre une pensée qui a pris pour point de départ les thèses d'une Nouvelle Droite traditionaliste, sur laquelle s'est greffé le futurisme, et l'autre reposant sur des bases libertariennes et cybernétiques qui ont muté vers une forme autoritaire. RAGE Site : rage-culture.com/ Tipeee: fr.tipeee.com/rage Twitter : twitter.com/RageCultureMag Discord : discord.gg/GXeSJ7XuNS Instagram : www.instagram.com/rage_cult/?hl=fr Telegram : t.me/rage_culture Facebook : www.facebook.com/RageCultureMag

Covfefe Anon joins me to discuss the ongoing dysfunction of the West, the 54th Clause of the Magna Carta, the woman question, history entangled with technology and the market, "do-somethingism" and much more. Covfefe Anon is a Twitter poster offering commentary from an NRx perspective. The threads and resources referenced in our chat: 1-2% execution per generation: https://evoandproud.blogspot.com/2015/03/in-wrong-place-at-wrong-time.html Rosedale thread: https://twitter.com/GodCloseMyEyes/status/1414619671056297984 Ethnic cleansing in the Bronx: http://bronxhistoricalsociety.org/wp-content/uploads/2018/07/M.Roby_.pdf --- Send in a voice message: https://anchor.fm/aksubversive/message

Hallowedwaters.com An Addiction for Steelhead, Salmon and Trout on the Swing - From the Great Lakes to the West Coast - Spey Casting Dynamics - Reading Steelhead Rivers and Bite Trigger Windows - Evolution of Modern Spey Flies and Swinging Tom Larimer established his steelhead and spey passion in Wisconsin and Michigan on Great Lakes Tributaries before heading to the west coast and the allure of the salty steel chrome brought him to the true indigenous Mecca of Oregon and Washington rivers where he guided for steelhead for many years and established his spey virtuosity talents. Besides writing some sweet pieces for magazines like Fly Fisherman and many others like Swing The Fly ,Chasing Silver and our Hallowed Waters Journal, Tom is a You Tube spey specialist and was also the host of” Skagit Masters”. He has done dozens of instructional videos that so many spey casters have found super helpful and instructional. Tom is now with G LOOMIS whose NRX technology I can't say enough amazing things about. - Matt --- Send in a voice message: https://anchor.fm/hallowedwaters/message

You can support this podcast and get early releases and bonus content at https://www.patreon.com/aksubversive Or check out my writing and the early releases on Substack at https://alexkaschuta.substack.com/ I chat to Auron about the IDW model of reality and why it is broken, Christianity and its role in the west, "no friends to the right", postmodernism and a right-wing critique of positivism, moral relativism vs. facts, NRx in the mainstream, anarchotyranny, class and the culture war and much more. Auron MacIntyre is a youtube and Twitter personality who offers political analysis and cultural critique from a right-wing, reactionary perspective. --- Send in a voice message: https://anchor.fm/aksubversive/message

Follow Buck on Twitter- @Ace_ArchistWatch Buck on the CounterFlow pod- https://www.youtube.com/channel/UC0RyQTjGxMeNGlfAFgeLS_APlease consider supporting my work-Patreon- https://www.patreon.com/nowayjose2020Check out TopLobsta's kickass threads- toplobsta.comGet No Way, Jose! merch- https://www.toplobsta.com/collections/no-way-josehttps://www.toplobsta.com/collections/no-way-jose-nwo#libertarian #josegalison #thelibertymovement #anarchy #anarchocapitalism #liberty #agorism #TLM #nowayjose #buckjohnson #buck #counterflow #NRX #paleo #WPI #libertarianpartyNo Way, Jose! Odysee Channel- https://odysee.com/@NoWayJose:7?r=JChxx9RMmW9PuL49z3PvTq4sxE2GjJrpNo Way, Jose! YouTube Channel- https://youtube.com/channel/UCzyrpy3eo37eiRTq0cXff0gMy Podcast Host- https://redcircle.com/shows/no-way-joseApple podcasts- https://podcasts.apple.com/us/podcast/no-way-jose/id1546040443Spotify- https://open.spotify.com/show/0xUIH4pZ0tM1UxARxPe6ThStitcher- https://www.stitcher.com/show/no-way-jose-2Amazon Music- https://music.amazon.com/podcasts/41237e28-c365-491c-9a31-2c6ef874d89d/No-Way-JoseGoogle Podcasts- https://www.google.com/podcasts?feed=aHR0cHM6Ly9mZWVkcy5yZWRjaXJjbGUuY29tL2ZkM2JkYTE3LTg2OTEtNDc5Ny05Mzc2LTc1M2ExZTE4NGQ5Yw%3D%3DRadioPublic- https://radiopublic.com/no-way-jose-6p1BAO Vurbl- https://vurbl.com/station/4qHi6pyWP9B/Feel free to contact me at thelibertymovementglobal@gmail.comAlso check me out on The Liberty Movement YouTube/BitChute ChannelTLM YouTube- https://www.youtube.com/c/TheLibertyMovement TLM BitChute- https://www.bitchute.com/channel/fke1BcIpm8mc/Check out The Liberty Movement on social mediaTLM FB group- https://www.facebook.com/groups/2362301217405657/?ref=shareTLM MeWe- https://mewe.com/join/thelibertymovement1Get TLM merch- https://teespring.com/stores/my-store-10232166?aid=marketplaceAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

#FordLightning #GloomisNRX+ #SegwayDirtBike Another day , Another Pod! Episode 479 Ford has announced their fully electric F-150 to be released on 19th of may the first one will be called the "Lightning " Harking back to the 90's classic powerhouse F-150 that was the worlds fastest ute when released! CEO of ford in an interview said it will be faster then the original which doesn't really mean anything as most cars especially electric are now faster 30 years later ? Hopefully it will be an insane electric beast the same as the lightning with its monster supercharger and big V8 was when it was released ! will be in show rooms mid 2022! so won't be long will keep you informed for prices and spec levels after release. Gloomis has announced its new rod series the NRX+ series 28 models to suit your style of fishing and $595 usd so not for the cheap at heart ! im sure like always will be a fantastic rd using spiral X tech and Multi taper tech to reduce even more weight ! As always looks like australia misses out to start with at least i have asked them if they will be releasing in australia? will let you know if they respond .. Segway Dirt E-Bike looks like a hell of a lot of fun !

Welcome to the showIt’s been fun to get to know other creators in this space, talking with Drew was no different. I’m not that old, but damn it’s cool to see these young dudes making a name for themselves.Real quick - go to follow.beenawake.com and catch me on your favorite social media outlet!We start out discussing the police and what it’s like to talk with people about your philosophy when it’s so outside of the mainstream. Drew discusses his influences growing up, and why he choose to produce such (awesome) short content. To the people still learning long form podcasting my advice is this: throw this conversation on the next time you’re driving somewhere, cleaning your house, or doing something menial. The cerebral fireworks will help you along your work better than whistling can accomplishChapters:0:00:00 - introductions0:08:00 - The police0:22:00 - why anarchy0:32::00 - what's in a name?0:34:00 - who can we talk to?0:39:00 - the racializing0:43:00 - victims of the algorhithm0:51:00 - Drew's process0:57:00 - 4GW, NRX, BLM1:03:00 - being serious in PoliticsAll the goodiesSubscribe to Drew’s youtube by visiting lockoutdays.comFollow Drew on TwitterIf you gained value from this interview, donate to the mission.buymeacoffee.com/beenawake This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit beenawake.substack.com/subscribe

QS/1 will release Service Pack 19.1.34 for NRx soon. It includes the new RedSail Technologies Patient Chart. Zach Princell, Pharm.D. and Assistant Product Manager, tells us more on how the new patient chart can help pharmacies as well as a few other of the new features included in the enhancements in the new service pack.

First of all, if you are on the New Calendar, Merry Christmas. I've recently gotten a lot of questions from fellow Orthodox people who aren't politically engaged as to what The America First and Groyper movement is about, so I've decided to hop on today and give a quick overview. Entropy let's me keep more of your Super Chats so......https://entropystream.live/app/SaintsEdwardMediaOnly 218 signatures away from our goal: http://chng.it/zVLxQ6VkOnly two more slots available for the New Years Eve Psalter reading: https://www.signupgenius.com/go/10c0d4da5ae23a7ffc07-newyearsFollow me on IG for West Virginia photos:@michaelsiscoseSupport the show (https://www.patreon.com/SaintsEdward)

Busy pharmacists rely on NRx to handle everything a day brings. It’s a complete solution built with decades of experience in the tools and integrations community pharmacists need. QS/1's Brian Sullivan talks about its streamlined workflow, modern health tools, flexible patient service, and how pharmacies can make sure they are getting all of the performance available.Visit www.qs1.com/nrx for more details.

Pharmacy is navigating tremendous demands now. QS/1 affirms its commitment to be here with you now – and well into the future. Our new parent company, RedSail Technologies, LLC, reflects the direction and confidence that come from game-changing new investment: in support services, core platforms, and accelerated innovation. Listen now to The Community of Now. You can also get more information at www.qs1.com/now.  

In this episode Endeavour joins the show to discuss The Cathedral, and whether or not it is Marxist, Progressive, or both. Is there conflict between the two ideologies? Will either prevail? Support the Saints Edward Media: https://www.patreon.com/SaintsEdwardPlaces to Watch: https://dlive.tv/MichaelSiscohttps://www.youtube.com/channel/UCIlR-stl0yx0HmCnZnA_b1Q?view_as=subscriberhttps://twitter.com/MichaelSiscoSEhttps://www.facebook.com/SaintsEdwardMediaLLCPlease visit our website: https://www.saintsedwardmedia.com/Support the show (https://www.patreon.com/SaintsEdward)

Buenas tardes con todos, hoy conversaremos con dos camaradas argentinos, ellos se autodenominan como "Reaccionarios" y son Reaxionario y Francisco; nosotros conversaremos esta tarde sobre el significado de "reaccionario" en su sentido tradicional y en su sentido actual, las bases y pensadores que toman como referencia cada uno dentro de su pensamiento, cómo los pintan los marxistas, autores reaccionarios en Latinoamérica, el mal uso y desuso de la palabra así también como uno de los temas más importantes del sector disidente: la mentalidad, ¿es más recomendable una mentalidad reaccionaria o revolucionaria? También conversaremos un poco sobre los pensadores del movimiento neoreaccionario (NRx) y/o Ilustración Oscura. Encuentralos en Twitter! El Reaccionario: https://twitter.com/altrightar Francisco: https://twitter.com/__almafuerte__ El blog de El Reaccionario: https://elreaccionarioarg.wordpress.com

NRx YouTuber, Endeavour, joins the show to discuss the Enlightenment and how it relates to our problems today, and how to go about fixing. Also discussed is the positive developments within the the America First movement! Endeavour's YouTube Channel: https://www.youtube.com/channel/UCsKBqLQmB1aCVuUC3e14riAFor updates on the show: https://twitter.com/PrytaneumTimesTo join our new meet up group network: https://www.patreon.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

Fr. Chris Johnson joins the show with a critique of the Reactionary Right. While I disagree, I do appreciate his insight and perspective. I'm looking forward to more interesting discussions with him going forward. Support the show (https://www.patreon.com/SaintsEdward)

Frank from Let's Be Frank comes on to discuss how exactly he became a Trump Supporter, and started his show. Apparently also he doesn't eat Mexican food very often. Below is his YouTube channel: https://www.youtube.com/user/MrFrankthetank30/featuredFollow him on Twitter: https://twitter.com/Letsbefrank2410Support our show for more great content! https://www.patreon.com/PrytaneumTimes$5 or more and you can join our exclusive Telegram community. Follow Michael on Twitter: https://twitter.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

On average, community pharmacies interact with patients with chronic disease(s) 35 times per year. In comparison, patients may only visit their primary care physician four times per year. This provides a huge opportunity for pharmacists to have an impact on their patients. QS/1’s Dr. Zachary Princell, PharmD talks about the value of eCare Plans.

Curt Doolittle in his humility, briefly and concisely describes Propertarianism and its differences with NRx. Follow him at: https://twitter.com/curtdoolittleSupport this show: https://www.patreon.com/PrytaneumTimes$5 or gets you in our private Telegram chat. Follow Michael Sisco for constant updates: https://twitter.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

Zachery Miller comes on to discuss how the motives of the El Paso shooter, and the root of cause of the violence inflicting our society. Support us on Patreon: https://www.patreon.com/PrytaneumTimesFollow Michael on Twitter: https://twitter.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

Deacon Nicholas Kotar returns quickly for another great episode! In this one he discusses the addictive nature of social media, the Amish approach to technology, and even participates in transhumanist thought experiment with Michael. Support the show (https://www.patreon.com/SaintsEdward)

Dcn. Nicholas Kotar comes joins us graciously to discuss the role of story telling in re-building a Christian culture. Join our exclusive Telegram chat by supporting us on Patreon:https://www.patreon.com/PrytaneumTimesTake the listener survey (copy & past)https://s.surveyplanet.com/33lB5Z4xWFollow Michael Sisco on Twitter:https://twitter.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

A GOP challenger to Trump! Thomas Kawczynski, author of "Becoming Civil War," explains how he will accomplish what Donald Trump has failed to do, and overcome the systems fatal flaws. https://www.endthecon.com/Support the show: https://www.patreon.com/PrytaneumTimesFollow Michael Sisco on Twitter: https://twitter.com/PrytaneumTimesAnd Facebook: https://www.facebook.com/PrytaneumTimes/Support the show (https://www.patreon.com/SaintsEdward)

Dave Martel comes on the show to explain his Asatru faith, particularly the Sedian Epicism branch. He also explains the commonalities shared with Traditional Christians, and why they make good allies in the fight against our secular degenerate world. Please consider supporting us here: https://www.patreon.com/PrytaneumTimesAlso, follow Michael Sisco on Twitter. https://twitter.com/PrytaneumTimesSupport the show (https://www.patreon.com/SaintsEdward)

Windows 7 will reach "end-of-life" on January 14, 2020. This means Microsoft will no longer update or support the operating system after that date. QS/1 is recommending pharmacies begin planning now about replacing any workstations and servers running Windows 7. QS/1's Les Hutchins talks about the process of sunsetting an operating system and how pharmacies can react to avoid a huge capital investment at one time.

Matthew Gerber comes on the show to discuss the philosophy behind his music, professional wrestling, and the Australian political scene. Did you know that in Australia the "liberal" party is actually the conservatives? Support the show (https://www.patreon.com/SaintsEdward)

Nathan Duffy appears as a guest to discuss Orthodox Christianity, tradition, and its relation to Reactionary thought. They also explore the role that the Church should play in relation to the State, and why Orthodoxies structure is well suited for a restoration of sovereign rule. Forgive the technical difficulties. The hosts audio was a little choppy in this one. Support the show (https://www.patreon.com/SaintsEdward)

The human experience has dramatically changed in recent years thanks in large part to social media and the internet. Special guest Stefanie Nicholas discusses the pros and cons of the digital revolution. Support the show (https://www.patreon.com/SaintsEdward)

Michael Sisco and Michael Witcoff discuss and critique a manifesto related to a certain unfortunate event.Support the show (https://www.patreon.com/SaintsEdward)

Neoreaction, or NRx, is a confusing topic with many implications on the current world of political ideology. It can not be understood without a deep familiarity with the mind of contemporary philosopher Nick Land, a detailed analysis of the concept Accelerationism, and a serious confrontation with the threat of Artificial Intelligence. Since these are concepts that we, two guys, have literally no expertise on, it's a pretty fun discussion.

DC Miller is a controversial but misunderstood person. He is a writer in London outcast from polite society after his opposition to the Shutdown LD50 campaign two years ago. I've talked with him enough to know he is not the evil caricature his enemies make him out to be, but I still don't understand his views fully. In this livestream we will try to get to the bottom of what DC really thinks. In doing so we make a series of distinctions about conservatives, fascists, neoreactionaries, and free-speech leftists. DC wrote the book, Dracula Rules the World and Mark Zuckerberg is His Son. You can find a list of his other writings at dcxmiller.tumblr.com. This was first recorded on March 8, 2019 as a livestream on Youtube. To receive notifications when future livestreams begin, subscribe to my channel with one click, then click the little bell. If you'd like to discuss this podcast with me and others, suggest future guests, or read/watch/listen to more content on these themes, request an invitation. Big thanks to all the patrons who keep this running.

Nyx Land is a blogger and internet persona in the accelerationist sphere. She explains to me her ideas about gender accelerationism and lesbian neoreaction. I believe this is the longest podcast I have ever done, clocking in just shy of 4 hours. Nyx's website is nyxus.xyz and her Twitter handle is @NyxLandUnlife. This podcast and my blog have now been unified! The website is now theotherlifenow.com. Big thanks to my supporters at patreon.com/jmrphy. You can also find other ways to support at theotherlifenow.com/support.

On this edition of Parallax Views returning guest Doug Lain, author of the sci-fi novel Bash Bash Revolution and publisher at Zero Books, discusses Zero Books severed ties with author Nicolas Hausdorf after finding out that he had began writing for the "post-political" (reactionary) magazine Jacobite. You can hear Doug discuss this issues with the author in question on Zero Squared #171: Pssst... Socialist Oppose Reaction.During the course of the conversation we discuss a number of topics ranging from how leftists activists end up going down the reactionary rabbit hole, free speech, the anti-SJW industry, Neoreaction (NRx) and its idea of The Cathedral, Doug's memories of the occult-flavored synchromystic subsculture of the 00's and how it may tie into these matters, whether "politics is downstream from culture", Moishe Postone's essay "History and Hopelessness: Mass Mobilization and Contemporary Forms of Anticapitalism" and unrefined manifestations of anti-imperialism on the Left, Adorno and the Frankfurt School's views on culture, alienation in political activists and the youth, Angela Nagle's critique of transgressive or "edgelord" culture, psychedelic and New Age reactionarism, socialism as "The Loyal Opposition", Jordan Peterson and the IDW vs. the reactionaries of the alt right and NRx, and more.And yes, Doug does speak about the recent kerfuffle around the recent Angela Nagle vs. Sargon of Akkad debate in this conversation.

The second episode of CURSED WITH GOOD IDEAS, an hour of free-wheeling takes with Joy Zhu (Hong Kong) and hosts Joshua Cader, Dino Chang & Gabriele de Seta. In this episode: uninformed opinions on Hong Kong's something-colonial identity, Wan Chin fandom, attempts at triggering Yuk Hui, and a broad sweeps over the city's political spectrum beyond the Umbrella Movement. Background noises courtesy of recording this thing over a total distance of 24,518 km. LINKS:- Tommy Cheung's article on Wan Chin: http://www.emeraldinsight.com/doi/abs/10.1108/AEDS-07-2015-0032 - Laika's take on Hong Kong's exit: https://jacobitemag.com/2017/09/23/colonialism-hong-kong-exit/ - Bruce Gilley's defense of colonialism: http://www.independent.co.uk/news/world/americas/colonialism-academic-article-bruce-gilley-threats-violence-published-withdrawn-third-world-quarterly-a7996371.html - Yuk Hui on NRx: http://www.e-flux.com/journal/81/125815/on-the-unhappy-consciousness-of-neoreactionaries/ Support CWGI: https://en.liberapay.com/CWGI/