Podcasts about pneumococcal

There are more than 100 known kinds of pneumococcal bacteria. They can cause serious infections in the lungs and other parts of the body. Each year, the U.S. sees about 30,000 cases of pneumococcal disease, which includes blood infections, brain and spine inflammation, and other problems. About 30 percent of cases are among people aged 50 to 64. 有100种已知类型的肺炎球菌细菌。 它们可能在肺部和身体其他部位引起严重的感染。 每年，美国都会看到大约30,000例肺炎球菌疾病，其中包括血液感染，脑和脊柱炎症以及其他问题。 大约30％的病例是50至64岁的人群。 The first pneumococcal vaccine was licensed in the U.S. in 1977. Since then, drugmakers have been coming up with newer versions that target several bacteria in a single shot. 1977年，第一种肺炎球菌疫苗在美国获得了许可。从那时起，制药商就提出了较新的版本，这些版本针对几种细菌。 There are four vaccines now in use. They include Prevnar 20 from Wyeth-Pfizer, and Vaxneuvance and Pneumovax 23 made by Merck. The U.S. Food and Drug Administration this year also approved Merck's Capvaxive, which can cost around $300 a treatment. The new shot can protect against 21 kinds of bacteria, including eight not included in other pneumococcal vaccines. A Merck spokesperson said it is designed to help protect against the bacteria that cause the majority of severe disease in adults aged 50 and older.现在有四种疫苗正在使用。 它们包括来自Wyeth-Pfizer的Prevnar 20，以及由Merck制造的VaxNeuvance和Pneumovax 23。 今年美国食品药品监督管理局还批准了默克的Capvaxive，该公司的每处理费用约为300美元。 新镜头可以预防21种细菌，其中包括其他肺炎球菌疫苗中未包含的8种。 默克公司发言人说，旨在帮助预防50岁及以上成年人的大多数严重疾病的细菌。In June, the CDC advisors recommended the vaccine as a possible shot for adults at higher risk. At the time, the group also talked about the possibility of lowering the age recommendation for older adults. They noted that infections causing sickness peak at age 55 to 59 among Black Americans — a lower age than found among white Americans. 6月，CDC顾问建议该疫苗可能是面对较高风险的成年人的可能性。 当时，该小组还谈到了降低老年人年龄建议的可能性。 他们指出，在黑人美国人中导致疾病峰值55至59岁的感染峰 - 比美国白人的年龄低。 Some scientists have concerns about the CDC recommendation. They say a second treatment, called a booster, may be necessary in about 15 years. And some new vaccines in development could force another update to the recommendations. 一些科学家对CDC建议感到担忧。 他们说，在大约15年内可能需要第二次称为助推器的治疗方法。 开发中的一些新疫苗可能会迫使建议另一项更新。 Dr. Jamie Loehr is the chair of the committee's pneumococcal working group. He was the only person to vote against the proposal. 杰米·洛尔（Jamie Loehr）博士是委员会肺炎球员工作组的主席。 他是唯一反对该提案的人。 He said, “Pneumococcal has been a very confusing recommendation for many, many years and it's hard to have a new recommendation every two or three years.” 他说：“多年来，肺炎球菌一直是一个非常令人困惑的建议，很难每两三年提出新的建议。”

American health officials say people age 50 and older should get vaccinated against bacteria that cause pneumonia and other dangerous diseases. 美国卫生官员说，50岁及50岁以上的人应接种导致肺炎和其他危险疾病的细菌。Pneumonia is an infection that affects the lungs. It makes breathing difficult and can cause a rise in body temperature. Pneumonia can also lead to a cough that produces yellow, green or bloody substances. 肺炎是一种影响肺部的感染。 它使呼吸困难，并可能导致体温升高。 肺炎也会导致产生黄色，绿色或血腥物质的咳嗽。 The advice, or recommendation, was offered by a group of scientific advisors and approved by the Centers for Disease Control and Prevention (CDC). The former age recommendation for adult vaccinations was 65 and older. 该建议或建议是由一组科学顾问提供的，并得到了疾病控制与预防中心（CDC）的批准。 以前对成人疫苗接种的年龄建议为65岁以上。 CDC Director Mandy Cohen said in a statement, “Now is a great time to get vaccinated against pneumococcal disease in preparation for the winter respiratory season.” 疾病预防控制中心（CDC）主任曼迪·科恩（Mandy Cohen）在一份声明中说：“现在是接种肺炎球菌疾病的好时机，为冬季呼吸道季节做准备。” The advisors voted 14-1 to change the age recommendation during an October meeting in Atlanta, Georgia, home of the CDC headquarters. Doctors widely follow the agency's guidance. 顾问以14-1投票决定在10月在佐治亚州亚特兰大举行的CDC总部故居的10月会议上改变年龄的建议。 医生广泛遵循该机构的指导。 Pneumococcal shot recommendations are sometimes called the most complex vaccination guidance that the government issues. 肺炎球菌射击建议有时被称为政府发出的最复杂的疫苗接种指导。 The CDC currently recommends shots for children younger than five and adults 50 or older, as long as they have never been vaccinated against pneumococcal disease. Officials also recommend the shots for children and adults at increased risk for pneumococcal disease, such as those with diabetes, liver disease or a weakened immune, or defense, system. 疾病预防控制中心目前建议对五岁以下的50岁以上的儿童拍摄，只要从未接种肺炎球菌疾病疫苗。 官员们还建议对儿童和成人的枪击事件，患有肺炎球菌疾病的风险增加，例如患有糖尿病，肝病或免疫力弱或防御系统的患者。

Dr Anna Giolito and Professor Naïm Ouldali join Josefine Gibson to discuss their latest research on dexamethasone for paediatric pneumococcal meningitis.Read the full article:https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00029-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanchiContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://www.linkedin.com/company/lanchi/https://youtube.com/thelancettv

The widespread use of pneumococcal conjugate vaccine (PCV) in children has dramatically lowered the incidence of pneumococcal disease through direct and indirect effects. Despite this progress, pneumococcal pneumonia still leads to more than 200,000 adult hospitalizations annually in the United States. Older adults, individuals with underlying health conditions, and certain racial groups continue to experience higher rates of pneumococcal disease. Dr. John Schoen, Senior Clinical Manager of Drug Information at the Vizient Center for Pharmacy Practice Excellence, joins Program Host Stacy Lauderdale to discuss the newest adult pneumococcal vaccine, PCV21, and recent updates to age-based pneumococcal vaccine recommendations.   Guest speakers:  John Schoen, Pharm.D, BCPS Senior Clinical Manager of Drug Information Vizient Center for Pharmacy Practice Excellence   Host:  Stacy Lauderdale, Pharm.D, BCPS Associate Vice President Vizient Center for Pharmacy Practice Excellence VerifiedRx Host   Show Notes:  [01:25-02:53] Background on PCV21 [02:54-07:56] Difference between PCV20 and PCV21 [07:57-16:15] Discussing the new ACIP recommendation to move the universal age for pneumococcal vaccination from 65 years of age down to 50 years of age and older [08:31-16:15] Why a healthy 50-year-old who has no risk factors for invasive pneumococcal disease should get a pneumococcal vaccination [16:16-17:57] Summary of other changes in the most recent MMWR [17:58-19:34] What organizations consider when selecting specific pneumococcal vaccines [19:35-21:18] What's in the pipeline for  pneumococcal vaccines   Links | Resources:  Publicly available resources Previous VerifiedRx podcasts on pneumococcal vaccines: What's pneu with pneumococcal vaccines? – March 29, 2022 What's pneu part 2: pneumococcal vaccines update – February 13, 2024 January 2024 MMWR - ACIP recommendations for the use of PCV in adults ≥ 50 years of age Vizient client exclusive resources 2025 pneumococcal vaccines side-by-side comparison   Subscribe Today! Apple Podcasts Amazon Podcasts Spotify Android RSS Feed

Listen to the SBS Sinhala discussion on deadly Pneumococcal disease on the rise in Australia - ඕස්ට්‍රේලියාවේ වසර 20 ක ඉහළම අගයක් ගන්නා අසාදන අනුපාතයක් ඇති Pneumococcal disease යන බැක්ටීරියා ආසාදන තත්වය සහ එමගින් ආරක්ෂා වීමට කල යුතු දේ පිළිබඳව SBS සිංහල සේවය සිදු කල සාකච්චාවට සවන් දෙන්න

New research indicates that over ¾ people know little or nothing about pneumococcal disease, and that a majority don't know that its treatable by vaccine. This comes after a clear link between it and pneumonia has been identified. To discuss this further Pat was joined on the show by Dr Sumi Dunne Clinical Lecturer, General Practitioner, and a former ‘expert' on Operation Transformation.

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Is a new COVID vaccine coming out? Which RSV vaccine is better? Are there new PCV vaccines? Which vaccines can be given together? When is the new flu shot available? Our guest is Sandra Fryhofer, MD, AMA's liaison to the Advisory Committee on Immunization Practices (ACIP), and a member of ACIP's COVID-19 Vaccine Workgroup. American Medical Association CXO Todd Unger hosts.

There have been quite a few updates to certain vaccinations over the past several years, so Anna and I are here this week to review these important updates with you. Regardless of the population you care for, these vaccines are ones you'll see in your clinical rotations or in practice, and you'll probably be asked about them by your patients.   Tune in this week to learn the updates in indication, administration schedule, and important patient education guidance concerning RSV, COVID, pneumococcal, and meningococcal vaccinations.   Get full show notes and more information here: https://blog.npreviews.com/vaccination-updates-covid/

Visit nascentmc.com for the full writup of this episode and medical writing assistance.  Visit learnamastyle.com for free downloads directed towards medical writing and editing. • The FDA has approved the 21-valent pneumococcal conjugate vaccine, CAPVAXIVE™ (Merck), for the prevention of invasive disease and pneumonia in adults aged 18 years and older caused by 21 Streptococcus pneumoniae serotypes. Capvaxive includes eight serotypes not covered by other pneumococcal vaccines, addressing approximately 27% of IPD cases in adults aged 50 and older, and 30% in adults aged 65 and older, based on CDC data from 2018-2021. The approval follows an FDA Priority Review and is based on immune responses measured in the Phase 3 STRIDE-3 trial, with continued approval contingent upon verification of clinical benefit in a confirmatory trial.  • The FDA has approved delandistrogene moxeparvovec-rokl (Elevidys) for Duchenne muscular dystrophy (DMD) in ambulatory individuals aged 4 and older with a confirmed mutation in the DMD gene, as well as granting accelerated approval for non-ambulatory individuals. Elevidys, a one-time intravenous gene therapy, delivers a working copy of the DMD gene to address the muscle degeneration caused by mutations in this gene. The approvals are based on findings from a confirmatory trial that, while not meeting its primary endpoint, showed success in several secondary measures, with the Phase 3 ENVISION study underway to serve as a postmarketing requirement. • The FDA has approved adagrasib (Krazati) plus cetuximab for adults with KRAS G12C-mutated locally advanced or metastatic colorectal cancer (CRC) who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. Adagrasib targets the KRAS G12C mutation, a common driver mutation in several cancers including colorectal cancer, while cetuximab enhances its antitumor activity. The approval was based on findings from the KRYSTAL-1 trial, which demonstrated a confirmed overall response rate (ORR) of 34% and a median duration of response (DOR) of 5.8 months. • The FDA has approved pembrolizumab (Keytruda) in combination with carboplatin and paclitaxel, followed by pembrolizumab monotherapy, to treat primary advanced or recurrent endometrial carcinoma in adults, marking the third endometrial carcinoma indication for Keytruda in the US. Keytruda enhances the body's immune response against tumor cells by blocking the interaction between PD-1 and its ligands, PD-L1 and PD-L2. The approval is based on results from the phase 3 KEYNOTE-868 clinical trial, which demonstrated significant improvements in progression-free survival for patients treated with Keytruda plus chemotherapy compared to those receiving a placebo with chemotherapy.  • The FDA has approved risankizumab-rzaa (Skyrizi) for the treatment of moderately to severely active ulcerative colitis in adults, making it the first specific anti–interleukin 23 monoclonal antibody indicated for both ulcerative colitis and moderate to severe Crohn's disease. Risankizumab-rzaa inhibits interleukin-23 (IL-23), a cytokine involved in inflammatory and immune responses, thereby reducing inflammation. The approval is based on data from two phase 3 clinical trials, INSPIRE and COMMAND, which demonstrated the achievement of clinical remission and endoscopic improvement. • A supplemental Biologics License Application (sBLA) has been submitted for guselkumab (Tremfya) for the treatment of adults with moderately to severely active Crohn's disease. Guselkumab, a fully-human, dual-acting monoclonal antibody that blocks IL-23 and binds to CD64, was previously approved for moderate-to-severe plaque psoriasis and active psoriatic arthritis. Support for the BLA is based on findings from the Phase 3 GALAXI and GRAVITI clinical trials.

Skyrizi has been approved for ulcerative colitis; New pneumococcal vaccine approved; An indictment may impact as much as 50,000 patients who need ADHD meds; Results announced for Moderna's next-gen COVID-19 vaccine; Farxiga approval expanded.

Broadcast from KSQD Santa Cruz on 6-13-2024 Alzheimer's Disease and APOE4 Gene Listener asks about the APOE4 gene and its association with Alzheimer's disease in the light of a recent sensationalistic Nature publication. The impact of amyloid beta and TAU proteins on Alzheimer's pathology. Differences in Alzheimer's risk among different ethnic groups with APOE4 with emphasis on the importance of cholesterol levels as a risk multiplier. Advice for a listener's husband dealing with chronic back pain and sciatica Dr. Dawn presents a basic checklist for evaluating back pain symptoms and determining the need for urgent medical intervention. Potential causes are discussed such as spinal nerve compression from various sources. In this case, Dr. Dawn made a specific suggestion of McKenzie exercises and emphasized the importance of seeing a sports medicine doctor or physiatrist for a comprehensive evaluation. Dr. Dawn responds to a caller about managing knee osteoarthritis The role of glucosamine, chondroitin, and topical diclofenac in treatment. Discussion on non-pharmaceutical approaches like heat application and massage. Potential interventions like steroid injections, hyaluronic acid, platelet rich plasma and their benefits and risks. Dr. Dawn answers a question about dietary oxalates and their impact on kidney stones She emphasizes the importance of the oxalate content in foods and its limited role in kidney stone formation. She emphasizes the importance of hydration and maintaining a healthy microbiome. For specific dietary guidelines on oxalate in foods she suggests using oxalate.org. A concerned parent asks about aluminum and other vaccine adjuvants like formaldehyde for their infant's 2 month well child visit She expresses conflicting fears of being mischaracterized as a vaccine denier by merely expressing concern about vaccination for her infant. Dr. Dawn provides a breakdown of the necessity, immediate urgency and risks of each recommended vaccine (Hepatitis B, DTaP, Polio, Hib, Pneumococcal, Rotavirus) and suggests a social contextualization strategy to perhaps delay Polio, rotavirus and Hep B in this family's social context while emphasizing the importance of certain vaccinations to prevent serious illnesses. Dr. Dawn cites intriguing ambiguities in the literature that support the counterintuitive idea that smaller doses of aluminum may have a greater accumulation in tissues of brain and reproductive tissues than larger doses, and promises to research this further in a future program.

Recorded and first published prior to the advent of PCV20.

Pink Sheet editors discuss Medicare spending projections for the Alzheimer's treatment Leqembi (:28), Janet Woodcock's new post-FDA role (12:28), and ongoing preparations for new pneumococcal vaccines that will reach the market soon (17:28). #business #pharma More On These Topics From The Pink Sheet Medicare Spending Forecast For Leqembi Reflects CMS Angst About Alzheimer's Drug Costs: https://pink.citeline.com/PS150095/Medicare-Spending-Forecast-For-Leqembi-Reflects-CMS-Angst-About-Alzheimers-Drug-Costs Woodcock Takes On Rare Disease Challenges In Retirement, Keeps FDA, Industry At Arm's Length: https://pink.citeline.com/PS150111/Woodcock-Takes-On-Rare-Disease-Challenges-In-Retirement-Keeps-FDA-Industry-At-Arms-Length Change Is Constant For Pneumococcal Vaccines: US CDC Prepares For Merck's V116: https://pink.citeline.com/PS150029/Change-Is-Constant-For-Pneumococcal-Vaccines-US-CDC-Prepares-For-Mercks-V116

Dr. Lisa Law and Dr. Randy Taplitz share the latest evidence-based recommendations from ASCO on vaccines in adults with cancer. They discuss recommended routine preventative vaccinations, additional vaccinations and revaccinations for adults undergoing HSCT, CD19 CAR-T treatment, or B cell-depleting therapy, guidance for adults with cancer traveling outside the U.S., and recommendations for vaccination of household and close contacts of adults with cancer. Dr. Law and Dr. Taplitz also share their insights on the guideline, including the importance of this guideline for adults with cancer and their clinicians, future advances in research, and current unmet needs. Read the full guideline, “Vaccination of Adults with Cancer: ASCO Guideline” at www.asco.org/supportive-care-guidelines. TRANSCRIPT This guideline, clinical tools, and resources are available at http://www.asco.org/supportive-care-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO.24.00032       The ASCO Specialty Societies Advancing Adult Immunization (SSAAI) Project is supported by the Centers for Disease Control and Prevention (CDC) of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award to the Council of Medical Specialty Societies (CMSS) (with 100 percent funded by CDC/HHS). The contents are those of the authors and do not necessarily represent the official views of nor endorsement, by CDC/HHS or the U.S. Government. Brittany Harvey: Hello, and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.  My name is Brittany Harvey, and today, I am interviewing Dr. Lisa Law from Kaiser Permanente and Dr. Randy Taplitz from City of Hope Comprehensive Cancer Center, authors on “Vaccination of Adults with Cancer: ASCO Guideline.” Thank you for being here, Dr. Law and Dr. Taplitz. Dr. Lisa Law: Thank you. Dr. Taplitz: Thank you, Brittany. Brittany Harvey: Before we discuss this guideline, I'd like to take note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Taplitz and Dr. Law, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes.  So then, to dive into the content, here first, Dr. Taplitz, can you provide a general overview of both the scope and purpose of this guideline on vaccination of adults with cancer? Dr. Randy Taplitz: Yes, so people with cancer often experience a compromised immune system due to a variety of factors. This includes chronic inflammation, impaired or decreased function of the hematopoietic system, and treatments that compromise their immune function. Because of this, people with cancer are at a higher risk for infection, including with vaccine-preventable diseases. Also, response to vaccines in patients with cancer may well be affected by this underlying immune status, and their anticancer therapy, as well as the severity of the underlying malignancy. The purpose of vaccination in this group of patients is to prevent infection or to attenuate the severity of the disease when infection cannot be fully prevented.   This ASCO review builds on a 2013 guideline by the Infectious Diseases Society of America, or IDSA, and uses what's called a systematic literature review of 102 publications between 2013 and 2023. This includes 24 systematic reviews, 14 randomized clinical trials, and 64 non-randomized studies. The largest body of evidence in these studies, not surprisingly, addresses COVID vaccines on the efficacy and safety of vaccines used by adults with cancer or their household contacts. ASCO convened an expert panel to review this evidence and formulate recommendations for vaccinations in this population. Brittany Harvey: Understood. I appreciate that context, Dr. Taplitz. So then, next, Dr. Law, I'd like to review the key recommendations of this guideline. The guideline addresses four overarching clinical questions. So starting with the first question, what are the recommended routine preventative vaccinations for adults with cancer? Dr. Lisa Law: Thank you, Brittany. Before I start, I just want to wholeheartedly thank the first author of this paper, Dr. Mini Kamboj, Dr. Elise Kohn from the NCI, as well as the ASCO staff in putting this publication and guideline together. It is a very, very important guideline, and I echo everything Dr. Taplitz just said.  So going back to your question, what are the recommended routine preventative vaccines for adults with cancer? As per this guideline, there are about 7 to 8 based on patient age and risk. Namely, they are: seasonal flu, RSV for those aged 60 or above, COVID-19, Tdap, Hepatitis B, Shingrix, Pneumococcal vaccine, and the HPV vaccine. These vaccines should ideally be given two to four weeks before therapy. However, non-live vaccines can be given anytime during or after chemo, immunotherapy, hormonal treatment, radiation, or surgery. Brittany Harvey: Excellent. Thank you for reviewing those vaccinations and the timing of them as well. So then, following those recommendations, Dr. Taplitz, what additional vaccinations and revaccinations are recommended for adults undergoing hematopoietic stem cell transplantation, CD19 CAR-T treatment, or B-cell depleting therapy?  Dr. Randy Taplitz: Many studies have shown that stem cell transplant recipients essentially lose immunity from childhood immunizations, and we know that these individuals are very vulnerable to infection, particularly in the first year after transplant. Revaccination is critical to help restore their immunity. The optimal timing of vaccination is based on our understanding of adequate immune reconstitution with B and T-cell recovery so that the individual can mount a response to the vaccine. We know that a lot of factors influence this immune reconstitution, including the age of the stem cell transplant recipient, the source of the donor, the time from transplant, graft-versus-host disease prophylaxis, the treatment and severity of graft-versus-host disease, and the vaccine type and antigens used.   There are a number of bodies throughout the world, IDSA as I mentioned, CDC, American Society for Transplant and Cellular Therapy, European Society for Blood and Marrow Transplant, and European Conference for Infections and Leukemia. All of these bodies have guidelines that approach vaccination in stem cell transplants. However, variation does exist in the use of a variety of things including whether to use immune predictors to help guide vaccination, and there is really not consensus on whether this immune predictor guided vaccination is more likely to produce a protective immune response versus a standardized schedule. In addition, the duration of protection is incompletely understood.  The bottom line in these guidelines is that they recommend complete revaccination starting for most vaccines at 6 to 12 months after stem cell transplant, in order to restore vaccine-induced immunity. And I just want to go through a few of the particulars. For COVID-19, which is a three-dose series in the primary series, influenza - generally high-dose influenza - and pneumococcal vaccine, PCV20 in general, ultimately four doses, can be administered, starting as early as three months after transplant. Although there is really not much data to guide the use of the recombinant zoster vaccine in allogeneic stem cell transplant, the vaccine can be administered after the end of antiviral prophylaxis, which in general is 12 to 18 months after allogeneic and 3 to 12 months after autologous stem cell transplant. Some of the other vaccines, such as hepatitis B, Tdap, meningococcal vaccines, and HPV revaccination in those less than 45 are also recommended.   I want to also spend the moment talking about the two recently licensed RSV vaccines, which were essentially studied in less compromised hosts and really without any immunogenicity data in stem cell transplant, and thus, there is no recommendation in this guideline for the use of these vaccines after transplant. Live vaccines, such as MMR and varicella – varicella would be in varicella-seronegative patients without a prior history of varicella – should be delayed for at least two years and only given in the absence of active graft-versus-host disease or immunosuppression.  Moving briefly to CAR T, which is an immunotherapy that involves adoptive cell therapy, given the available data and after a review by the group, it was recommended that adults with hematopoietic malignancies receiving CAR T therapy directed against B-cell antigens should receive influenza and COVID-19 vaccines either two weeks before lymphodepletion or no sooner than three months after the completion of therapy. Administration of non-live vaccines preferably should occur before CAR T treatment or at least 6 to 12 months after, following the same timing as what we recommend for stem cell transplant. There is really little data to guide the safety and timing of administration of live vaccines after CAR T therapy.   In terms of adults receiving B-cell depleting therapy, they are generally unable for time to mount an effective humoral response but may have at least partially intact cellular immune responses. They are encouraged to be revaccinated for COVID-19 no sooner than six months after completion of B-cell depleting therapy, and they should receive influenza vaccine approximately four weeks from the most recent treatment dose for patients on chronic therapy. For other non-seasonal immunizations, vaccines ideally should be given two to four weeks before commencing anti-CD20 therapy or delayed until 6 to 12 months after completion, except for the recombinant zoster vaccine, which can be given one month after the most recent dose of B-cell depleting therapy. Brittany Harvey: I appreciate you reviewing each of those vaccinations and when they should be given, and reviewing the available data – albeit, limited data – in these situations.  So beyond these routine preventative vaccinations and revaccinations that you've both just described, Dr. Law, what additional vaccinations does the expert panel recommend for adults with cancer traveling outside the United States? Dr. Lisa Law: Good question. As per these ASCO guidelines, adults with solid or blood cancer traveling outside of the United States should follow the CDC standard recommendations for their destination. For the 2024 CDC Yellow Book, travel vaccines, in general, should be delayed until three months from the last chemotherapy or, and for those with solid tumors, ideally when the disease is in remission. Of note, hepatitis A, typhoid, inactivated polio, Hep B, rabies, meningococcal vaccine, and Japanese encephalitis vaccines are considered to be safe. In all cases of travel, patients should be counseled by their healthcare provider about the travel timing, with the additional attention to the regional seasonality of infections, for instance, influenza is more common in late summer in Australia, and also with attention to any outbreaks that may be occurring globally at the time of travel. Brittany Harvey: Absolutely. Those are key points for clinicians to discuss with their patients as they consider upcoming travel.  So then, the final clinical question that the panel addressed, Dr. Taplitz, what vaccinations does the panel recommend for household and close contacts of adults with cancer?  Dr. Randy Taplitz: Thank you. Yes, it is recommended that all household members and close contacts, when possible, be up to date on their vaccinations. And the only further thing I would say is that there are some special considerations for the use of live vaccines in household contacts, particularly in stem cell transplant recipients. Contacts of people who receive stem cell transplants should preferably receive inactivated influenza vaccines. As was mentioned, MMR and varicella vaccines are both safe to administer to close contacts. Vaccine strain transmission to immunocompromised hosts has not been associated with MMR use in family members.   Eleven cases of the varicella vaccine strain transmission are described in the published literature, but none occurred in compromised hosts. Because the vaccine strain can cause severe and fatal varicella in profoundly immunocompromised people, precautions are advised to avoid close contact with a person with a vaccine-induced rash. For household contact travelers, MMR and yellow fever vaccines are considered safe. Oral cholera should be avoided. For smallpox vaccines, the second-generation ACAM2000 has rarely been associated with vaccinia transmission and should be avoided because of this. But the live replication-deficient MVA-based JYNNEOS vaccine is felt to be safe for household contacts of immunocompromised individuals. Brittany Harvey: I appreciate you reviewing the importance of vaccination for household and close contacts, and some of those precautions that individuals should take. I appreciate you both for reviewing all of these recommendations.  So then in your view, Dr. Law, what is the importance of this guideline, and how will it impact both clinicians and adults with cancer? Dr. Lisa Law: In my opinion, this is a very important guideline that is long overdue in the oncology community and will have a huge impact on both clinicians and adults with cancer. Over the years, I have often been asked by my colleagues and patients, “Can I have the flu vaccine, and if so, when?” So this guideline really is going to be helpful. More importantly, our cancer patients are living much longer. They may have years of quality of life even with third or fourth line of treatment, especially, for instance, like CAR T for myeloma and lymphoma. However, we know that with additional treatment, that carries a substantial risk of infection complication among these immunocompromised patients. So it is of paramount importance to inform our patients and colleagues to be proactive in advocating preventive therapy ahead of time, meaning trying to get the patients appropriately vaccinated as early as possible to generate immunity.  Another case in point is the Shingrix vaccine. I used to see lots of shingles, but ever since we have the recombinant Shingrix, I have fewer encounters. And this is huge because post-herpetic neuralgia robs a patient's quality of life. So, again, it is very important to recommend appropriate vaccines for our cancer patients.  Brittany Harvey: Absolutely. It is key to ensure patients receive these preventative vaccines, and we hope that this guideline puts an emphasis on that for clinicians and patients.  So finally, to wrap us up, Dr. Taplitz, what are the current gaps in knowledge regarding the vaccination of people with cancer? Dr. Randy Taplitz: There are a number of really important gaps in knowledge and really critical unmet needs that require research and other dedicated efforts. Among these are, and I think paramount, are really the participation of people with cancer with varied types of immunocompromise in vaccine trials. Where vaccine trials are only for cancer patients, obviously is ideal, testing vaccines in the appropriate population. But when that's not feasible, pre-existing cancer should not preclude eligibility, and inclusion of cohorts of people receiving anticancer treatment should be incorporated prospectively. So that's really critical because the quality of our guidelines is based upon the data. We use the data for developing guidelines and gathering more data in the particular patient population is really, really critical.  Secondly, work for creating more immunogenic vaccines and research to understand the immune response to vaccines after immuno-depleting therapies, particularly with newer therapies such as CAR T and newer B cell therapies, bispecific antibodies, etc. is really critical. We need to really understand the immune response and have the most potent vaccines available to these people who may have impaired immune responses.  Switching gears a little bit, we really need mechanisms to promote institutional commitment to integrate and sustain immunization best practices for people with cancer. This will largely be through multidisciplinary, team-based approaches, protocol-based vaccination standing orders, and leveraging data sharing so that we can all be on the same page with giving vaccines to these individuals. We also need education and evidence-based decision-making tools, emphasizing preventive care through immunization, the availability of educational resources to clinicians and patients to address commonly asked questions and also misconceptions about vaccination, that's absolutely critical.  And finally, I think we need to develop strategies for addressing unique challenges and factors contributing to vaccine hesitancy during cancer therapy. We need to focus on patient and clinician communication, and very importantly, we need to consider health equity considerations in the development and approach to vaccines in these compromised patients. Brittany Harvey: Definitely, we'll look forward to research and advances in these areas that you've just described to support these guidelines and increase vaccine uptake.  So I want to thank you both so much for your work on this important guideline, and thank you for your time today, Dr. Law and Dr. Taplitz. Dr. Lisa Law: Thank you.  Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/supportive-care-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast, and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.      

Pneumococcal vaccines have been instrumental in decreasing invasive disease since their introduction in the 1980s. 2021 brought regulatory changes and recent ACIP recommendations were published in the Morbidity and Mortality Weekly Report, also known as MMWR. Dr. John Schoen, Senior Clinical Manager of Evidence-Based Medicine and Drug Information shares his insights on these changes with host Gretchen Brummel.      Guest speakers:   John Schoen, PharmD, BCPS Senior Clinical Manager of Evidence-Based Medicine and Drug Information Vizient Center for Pharmacy Practice Excellence      Host:   Gretchen Brummel, PharmD, BCPS   Pharmacy Executive Director   Vizient Center for Pharmacy Practice Excellence     Show Notes:   Recorded in the Fall of 2023 [01:00-03:34] What's new since March 2022 with pneumococcal vaccines  [03:35-06:51] Changes with the adult recommendations [06:52-13:10] New recommendations from CDC as well as published recommendations for adults [13:11-19:05] Recommendations for Pneumococcal vaccines in pediatrics [19:06-21:46] The area of biggest risk moving forward [21:47-24:07] What we are looking at for the future        Links | Resources:   Vizient pneumococcal vaccine side-by-side comparison Click Here ACIP pneumococcal vaccine recommendations Click Here   Subscribe Today! Apple Podcasts Amazon Podcasts Google Podcasts Spotify Android RSS Feed

For the AMA Style cheat sheet learnamastyle.com See the full write ups for today's episode at nascentmc.com/podcast Here are the highlights:  Test for Risk of Opioid Addiction:The FDA has approved AvertD by SOLVD Health, a test for assessing opioid addiction risk in individuals over 18, using genetic variants to evaluate addiction risk before prescribing oral opioids for acute pain; however, it's met with skepticism and not intended for chronic pain patients. https://www.cnn.com/2023/12/20/health/opioid-use-disorder-test-avertd/index.html https://avertdtest.com/  Filsuvez for Junctional Epidermolysis Bullosa:Filsuvez, a birch triterpenes topical gel, received FDA approval for treating Junctional and Dystrophic Epidermolysis Bullosa (JEB/DEB) in individuals aged 6 months and older, marking the first FDA-approved therapy for JEB's partial thickness wounds and a significant advancement in managing this debilitating skin disorder.https://resources.chiesiusa.com/Filsuvez/FILSUVEZ_PI.pdf Budesonide for IgA Nephropathy:Budesonide (Tarpeyo) received full FDA approval for reducing kidney function loss in adults with IgA nephropathy (IgAN), targeting specific antibodies implicated in IgAN based on phase 3 NefIgArd clinical trial data, marking the first FDA approval for IgAN treatment based on kidney function measures. https://www.tarpeyo.com/prescribinginformation.pdf Eplontersen for hATTR Polyneuropathy:Eplontersen (Wainua) was approved by the FDA for treating polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR-PN), based on the NEURO-TTRansform Phase III trial, and is the only hATTR-PN treatment that can be self-administered via an auto-injector. https://pubmed.ncbi.nlm.nih.gov/37768671/ https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217388s000lbl.pdf NRX-101 for Complicated UTI:The FDA cleared an Investigational New Drug application for NRX-101, a D-cycloserine and lurasidone blend developed by NRx Pharmaceuticals for treating complicated urinary tract infections, with a pending request for Qualified Infectious Disease Product designation. https://www.prnewswire.com/news-releases/nrx-pharmaceuticals-announces-fda-clearance-of-its-investigational-new-drug-ind-application-for-nrx-101-in-the-treatment-of-complicated-urinary-tract-infections-302017523.html?utm_source=pocket_saves Gefapixant for Chronic Cough:Merck's gefapixant, a selective antagonist of P2X3 receptors for treating chronic cough, was rejected by the FDA for the second time due to insufficient evidence of effectiveness in treating refractory or unexplained chronic cough in adults. https://www.businesswire.com/news/home/20231220302305/en/Merck-Provides-U.S.-Regulatory-Update-on-Gefapixant V116 for Invasive Pneumococcal Disease:Merck's V116, a 21-valent pneumococcal conjugate vaccine, was accepted by the FDA for priority review to prevent invasive pneumococcal disease in adults, based on STRIDE-3 Phase 3 trial data, with a target action date set for June 17, 2024. https://www.merck.com/news/fda-grants-priority-review-to-mercks-new-biologics-license-application-for-v116-an-investigational-21-valent-pneumococcal-conjugate-vaccine-specifically-designed-to-protect-adults Sotorasib in NSCLC:Lumakras (sotorasib), already under accelerated approval for KRASG12C-mutated non-small cell lung cancer (NSCLC), faces uncertainty for full FDA approval after an advisory committee voted against it, though it will remain available for clinical use.https://www.onclive.com/view/codebreak-200-sotorasib-in-second-line-kras-g12c-mutated-nsclc nascentmc.comlearnAMAstyle.com

Topical gel approved to treat partial thickness wounds in epidermolysis bullosa; Priority Review given to 21-valent pneumococcal conjugate vaccine; sensory and motor stimuli video game for ADHD gains expanded age approval; on-demand HIV prevention for women; multiple food allergy drug

Dr. Aileen Marty, Infectious Disease Specialist and Professor at Florida International University, joined Bob Sirott to talk about the latest health news. Dr. Marty talks about a new recommendation from the CDC concerning a pneumococcal vaccine for people who are nineteen years old and older.

In this episode Sean O'Leary, MD, MPH, FAAP, chair of the AAP Committee on Infectious Diseases, joins hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, for an “immunizations omnibus.” He describes newly approved products to protect against RSV, COVID and pneumococcal disease, and he predicts a difficult flu season. For resources go to aap.org/podcast.

Pneumococcal vaccination recommendations are arguably some of the most difficult to maneuver. With the approval of two new pneumococcal vaccines, guidelines have significantly changed. This podcast aims to discuss these changes in vaccines and recommendations, and provide resources to ensure patients are receiving the right vaccine at the right time. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Host: Joyce Riley Guest: Lance Sloan, MD Pneumococcal vaccination isn't restricted to a specific season. Patients can get vaccinated with Prevnar 20 at any time. Clinicians can help their patients better understand the importance of pneumococcal vaccination. Join Joyce Riley as she gets expert insights from Dr. Lance Sloan, Endocrinologist, Nephrologist, and Metabolist in Lufkin, Texas. Continuing medical education credits are not available for this program.© 2023 Pfizer Inc. All rights reserved. PP-PRV-USA-0378

Drs Michael S. Saag and David H. Spach discuss HIV and the nuances of primary care treatment, with a special focus on vaccines, including COVID, hepatitis, varicella zoster virus, and mpox. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986508). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources HIV Infection and AIDS https://emedicine.medscape.com/article/211316-overview HIV and Immunizations https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-and-immunizations HRSA Ryan White HIV/AIDS Program https://ryanwhite.hrsa.gov/about/parts-and-initiatives Pneumococcal Vaccination https://www.cdc.gov/pneumococcal/vaccination.html Incidence and Risk Factors for Invasive Pneumococcal Disease in HIV-Positive Individuals in the Era of Highly Active Antiretroviral Therapy https://pubmed.ncbi.nlm.nih.gov/30999829/ Pneumococcal 7-Valent Conjugate Vaccine https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pneumococcal-7-valent-conjugate-vaccine Immunizations for Preventable Diseases in Adults and Adolescents Living With HIV https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/immunizations Drug Database: Hepatitis B Vaccine https://clinicalinfo.hiv.gov/en/drugs/hepatitis-b-vaccine/patient Interpretation of Hepatitis B Laboratory Results https://www.cdc.gov/hepatitis/statistics/surveillanceguidance/docs/viral-hepatitis-surveillance-table-3-1_508.pdf Screening and Testing for Hepatitis B Virus infection: CDC Recommendations — United States, 2023 https://www.cdc.gov/mmwr/volumes/72/rr/rr7201a1.htm?s_cid=rr7201a1_w Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV: Hepatitis B Virus Infection https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/hepatitis-b-0?view=full Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/what-start-initial-combination-regimens Cabotegravir/Rilpivirine (Rx) Cabenuva (cabotegravir/rilpivirine) dosing, indications, interactions, adverse effects, and more https://reference.medscape.com/drug/cabenuva-cabotegravir-rilpivirine-4000156 Dolutegravir/Lamivudine as a First-Line Regimen in a Test-and-Treat Setting for Newly Diagnosed People Living With HIV https://pubmed.ncbi.nlm.nih.gov/34115650/ Systematic Review and Meta-analysis of Immune Response of Double Dose of Hepatitis B Vaccination in HIV-Infected Patients https://pubmed.ncbi.nlm.nih.gov/32334887/ Heplisav-B® (HepB-CpG) Vaccine https://www.cdc.gov/vaccines/schedules/vacc-updates/heplisav-b.html PreHevbrio: A New 3-Antigen Hepatitis B Vaccine for Adults https://pubmed.ncbi.nlm.nih.gov/35906803/ Hepatitis A Vaccine Inactivated (Rx) https://reference.medscape.com/drug/vaqta-havrix-hepatitis-a-vaccine-inactivated-343150 Hepatitis A/B Vaccine (Rx) https://reference.medscape.com/drug/twinrix-hepatitis-a-b-vaccine-343152 Zoster Vaccine Recombinant (Rx) https://reference.medscape.com/drug/shingrix-zoster-vaccine-recombinant-1000163 Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 https://www.cdc.gov/mmwr/volumes/71/wr/mm7103a2.htm#:~:text=On%20October%2020%2C%202021%2C%20ACIP,for%20use%20in%20immunocompromised%20persons. Live Attenuated Influenza Vaccine [LAIV] (The Nasal Spray Flu Vaccine) https://www.cdc.gov/flu/prevent/nasalspray.htm MMR Vaccine https://www.ncbi.nlm.nih.gov/books/NBK554450/

In this episode of Matter of Vax Podcast, host Steph O'Connell interviews Professor Robert Booy about pneumococcal and meningococcal diseases. Pneumococcal and meningococcal are caused by a bacterium that can quickly lead to serious disease including pneumonia, meningitis and septicemia. Vaccination is critical for prevention. Professor Booy emphasizes the importance of implementing routine vaccination for all at-risk individuals to effectively combat these dangerous diseases. Visit Immunisation Foundation of Australia for more information Host Steph O'Connell is a public health advocate with 25 years' experience in strategic communications. She became a public voice for vaccinations when her daughter, Lily (23), narrowly survived W strain of Meningococcal on Christmas Day, 2017. Nine months later her sister, Grace, donated a kidney that has since transformed Lily's life.  Steph's advocacy for immunisation awareness and vaccination became a collaboration in 2018 with Meningococcal Australia and resulted in Meningococcal vaccination campaigns by the Australian Government Department of Health and NSW Health. Lily's story quickly resonated with audiences and became a national and international appeal for awareness, education and vaccination.  Steph's work expanded during the pandemic and today she continues to advocate for improved access to vaccines, public education for lifelong vaccination behaviour and policy reform. MatterofVax, in collaboration with Immunisation Foundation of Australia takes a look at topical immunisation issues on video and podcast.  Matter of Vax is produced by Ampel, for Immunisation Foundation of Australia. See omnystudio.com/listener for privacy information.

Tune in to hear Charles Jones, Vaccine Industry Leader at Pfizer, discuss the future of vaccines in the marketplace. Topics include: Changes seen in the marketplace and the competitive landscape Challenges of the changing schedule for preventative products such as flu immunization, COVID-19, Pneumococcal, shingle vaccines, and moreThe role of policy makers, like The Advisory Committee on Immunization Practices (ACIP) in the US and all the various participants, and the impacts they have on the value chain and the future of the ecosystemSpeakers:Charles Jones, Vaccine Industry Leader, Pfizer Amy Hunckler, Pharma and Life Sciences Managing Director, PwC May Weiser, Pharma and Life Sciences Director, PwC Igor Belokrinitsky, Strategy& Principal, PwCFor more information, please visit us at: https://www.pwc.com/us/en/industries/health-industries/health-research-institute/next-in-health-podcast.html.

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

- How to Protect Yourself & Your Loved Ones from COVID, Omicron & Delta Variants - COVID Vaccines & Booster Vaccines - Other Vaccines - Flu, Pneumococcal & Shingles Vaccines - COVID & People Living with Cancer - Where to Find Reliable Information Regarding this Pandemic & Its Variants - How to Protect Yourself, Loved Ones & Children from COVID & Its Variants - The Increasing Role of Telemedicine/Telehealth Appointments - How to Prepare for Your Telemedicine/Telehealth Appointments, including Prepared List of Questions, Follow-Up Appointments, Quality-of-Life Concerns & Discussion of OpenNotes - Working Closely with Your Health Care Team about Your Wishes & Health Care Directives - Tips to Manage the Practical, Emotional & Financial Stresses Related to COVID, Omicron Variants & Cancer - Self-Care & Stress Management Tips - Questions for Our Panel of Experts

A recent study from Otago University, Christchurch supports the need for a stronger strain of immunisations against pneumococcal, know as PVC-13. Co-author of the study, Professor Tony Walls speaks to Jesse.

Medicare now covers the Shingles Vaccine at no out of pocket cost to you! Find out about Medicare Part D and Medicare Part B and what is covered, such as Hepatitis B, Influenza and Pneumococcal vaccine shots. Questions? Call Toni at 832-519-8664, or write info@tonisays.com and visit www.seniorresourcebooks.com for your free Medicare Prescription Drug Survival Guide and other free E-books. See omnystudio.com/listener for privacy information.

Restoration of the Saints (11) (Audio) David Eells - 11/2/22 Destroying Your DNA or Restoring Your DNA     First - We will talk about things to pray down. Last we will see the ultimate cure for your DNA the criminals can do nothing about. The injured will soon be dead unless they turn to God and believe His Word about health. Please read our free book titled, God's Vaccine Deaths are rising geometrically from the jab and the carriers. This fits with the reports of deaths in Revelations in the Tribulation.  Rev 6:8  And I saw, and behold, a pale horse: and he that sat upon him, his name was Death; and Hades followed with him. And there was given unto them authority over the fourth part of the earth, to kill with sword, and with famine, and with death (Numeric - pestilence), and by the wild beasts of the earth. This clearly show the tribulation is close. In Rev 6:1-4 at the beginning of Tribulation the Man-child body of reformers come and then the first real World War with multitudes dead.  So now we have the DS facing off with the “Earth Alliance" of nations all over the World. This is truly a world civil war.  Obviously, biologicals have been used and nukes will be used (eventually). Riots are coming over food, heating, job losses, stolen elections, and vaccine mandates.  Then Martial Law and all-out war against the DS.     20 Million Dead from the Jab, 2.2 Billion Injured – Analyst Estimates The Vigilant Fox - Oct 10, 2022 (David's notes in red) One of the big pieces of news to come out recently is this Substack piece from Peter Halligan, which then turned into an article by The Exposé. Peter is a most-experienced analyst in the financial industry and is very skilled at looking at and translating statistics into a summary statement. Now, the number 20 million dead sounds absolutely ridiculous at first glance, but when you dig into the data, it makes sense. Here is how Peter came to the 20 million number. So, EU+US deaths (EUDRA + VAERS) = 13,972 + 46,999 = 60,971 deaths and EU+US injuries = 854,084 + 6,089,773 = 6,943,857 (multiple per person, half of which are “serious”). Multiply by 40 for URF (underreporting factor) and then (multiply) by 8 to “globalize” (the total number). Global deaths are around 19.5 million SO FAR, and global injuries are around 2.2 billion. Those injuries are likely to develop into “conditions” and then morbidities. WHO do you believe?   Dr. Roger Hodkinson, an esteemed Canadian pathologist, joined Laura-Lynn Tyler Thompson in a video interview, where he discussed these horrifying numbers. These numbers are best estimates, at this point in time, using government data for the global consequences of the clot shot in terms of death and morbidity … Now, these numbers are beyond staggering. To contrast that with history, vaccines have typically been pulled from the market – the last one, the bird flu vaccine – was pulled with only 35 … deaths. I hope people can appreciate the scale of what is going on here. An unimaginable carnage WHICH ISN'T OVER because that number – first of all, is the current estimate. It does not include future deaths of a similar type, which will be cumulative on top of that. It does not include stillbirths. It does not include those avoidable deaths due to having had a one-disease healthcare system for two and a half years, with people not being treated or investigated for cancer …, for example. Those numbers are not included. The numbers from the lockdowns, the suicides, are not included. And also not included are the future deaths that we're anticipating from a rapid increase in the rate of cancer presentations and fatal infections because of immune suppression induced by the clot shot. Those factors are IN ADDITION TO those jaw-dropping numbers that I just mentioned. This is truly horrifying to think about, and there's no doubt – this is a war on humanity. Those responsible and complicit in this crime against humanity NEED to be held accountable. Luckily, we have people like attorney Tom Renz, Dr. Henry Ealy, Dr. David Martin, and others working hard to make that happen.   Biden's Executive Order Designed to Release Transhumanist Hell on America Gateway Pundit by Jim Hoft - 9/13/22 If anyone needed proof that the powers pushing the levers behind the mindless moron who sits in the Oval Office are fully on board with the World Economic Forum/United Nations agenda of biomedical tyranny and trans-humanism, look no further than the executive order that Joe Biden signed on Monday, September 12. By quietly getting Biden's signature on this document, his handlers may have given us the most ominous sign yet that we stand on the threshold of a technocratic one-world beast system. Prepare to make your stand because it's about to get much more intense. This document's Orwellian title, Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy, will assure that its significance will fly right over the heads of 99 percent of the media, even the conservative media. They will read it and yawn. I plead with everyone reading this article to please not make that same mistake. Here is a quote from the Biden Executive order:   "For biotechnology and biomanufacturing to help us achieve our societal goals, the United States needs to invest in foundational scientific capabilities, We need to develop genetic engineering technologies and techniques to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers; unlock the power of biological data, including through computing tools and artificial intelligence; and advance the science of scale‑up production while reducing the obstacles for commercialization so that innovative technologies and products can reach markets faster."   Because of the arcane scientific language in which this document (above) is written, even most of those who take the time to read and study it (I assure you Biden did not) will not fully grasp what is being ordered by the White House. Karen Kingston, a former Pfizer employee and current analyst for the pharmaceutical and medical-device industries, helps us decipher what's going on in this executive order. Kingston stated in a Twitter post: “Let me read between the lines for America. Biden's Sept. 12, 2022, executive order declares that Americans must surrender all human rights that stand in the way of trans-humanism. Clinical trial safety standards and informed consent will be eradicated as they stand in the way of universally unleashing gene-editing technologies needed to merge humans with A.I. In order to achieve the societal goals of the New World Order, crimes against humanity are not only legal, but mandatory.” Patrick Wood, an economist and author of several books on technocracy, has been following the trans-humanist and global technocracy movements for four decades. He told me that Kingston is not overstating the issue. He said this E.O. is proof that the executive branch is now owned lock, stock and barrel by the biomedical/pharmaceutical industry. It will be Katy bar the door from here on out. “The trans-humanists within Big Pharma have completely taken over government policy and taxpayer funds to promote their own anti-human agenda of hacking the software of life,” Wood told me. “It also clearly demonstrates who has the power, and who sets the policies in America.” The mRNA injections that have already gone into the bodies of at least 70 percent of adults in the U.S. mark the gateway to trans-humanism. We have been told this by Kingston as well as by the late Dr. Zev Zelenko and Dr. Robert Malone, a co-inventor of the mRNA platform. LeoHohmann.com was one of the first sites to blow the whistle on Moderna's former chief medical officer, Tal Zaks, who told the world straight up in December 2017 that “We have hacked the software of life,” and that this mRNA gene-editing biotechnology would be incorporated into vaccines to treat and prevent all manner of illnesses. We've seen how well they work, with millions getting sick and even dying after getting two or more doses of the Covid injections offered up by Moderna and Pfizer. With the FDA and CDC now totally on board, this mRNA technology is being included in scores of other vaccines, including flu shots. The September 12 executive order was no doubt put in place as back up for the continued experimentation on the human population, and I expect the vaccine industry will exploit it to the max. Soon we will see the return of vax mandates, this time more ferociously policed and enforced than before. This E.O. may also have been timed at least partly in anticipation of the new pandemic treaty that the Biden administration is hoping to get passed through the United Nations World Health Organization next year. This treaty will transfer sovereignty over matters of “health emergencies” from the national level to the WHO. Wood said the E.O.'s intended consequences is to push the frontier of genetic modification of all living things and especially humans. He believes this will ultimately spark the biggest public backlash in modern history. “Biden pledges not only funding but an all-of-government transformation to support this anti-human scheme from top to bottom,” Wood writes. “It also automatically blocks any agency or department from dissent.” Below are just a few of the highlights quoted directly from the document:   The term “biotechnology” means technology that applies to or is enabled by life sciences innovation or product development.   The term “bio-manufacturing” means the use of biological systems to develop products, tools, and processes at commercial scale.   The term “bioeconomy” means economic activity derived from the life sciences, particularly in the areas of biotechnology and biomanufacturing, and includes industries, products, services, and the workforce.   The term “biological data” means the information, including associated descriptors, derived from the structure, function, or process of a biological system(s) that is measured, collected, or aggregated for analysis.   The term “key R&D areas” includes fundamental R&D of emerging biotechnologies, including engineering biology; predictive engineering of complex biological systems, including the designing, building, testing, and modeling of entire living cells, cell components, or cellular systems; quantitative and theory-driven multi-disciplinary research to maximize convergence with other enabling technologies; and regulatory science, including the development of new information, criteria, tools, models, and approaches to inform and assist regulatory decision-making.  These R&D priorities should be coupled with advances in predictive modeling, data analytics, artificial intelligence, bioinformatics, high-performance and other advanced computing systems, metrology and data-driven standards, and other non-life science enabling technologies.   The term “life sciences” means all sciences that study or use living organisms, viruses, or their products, including all disciplines of biology and all applications of the biological sciences (including biotechnology, genomics, proteomics, bioinformatics, and pharmaceutical and biomedical research and techniques), but excluding scientific studies associated with radioactive materials or toxic chemicals that are not of biological origin or synthetic analogues of toxins.   What this means is that human beings will be data mined for their most personal possession, their DNA and genomic properties, and the government will offer no protection. It will actually be encouraged and seen as a green light for biomedical practitioners worldwide. It is the goal of the technocratic proprietors of Agenda 2030 to catalogue, map out, and monitor every living thing on earth. This was spelled out in the early 2000s by the late researcher Rosa Koire and put into book form in 2011 with “Behind the Green Mask: U.N. Agenda 21.” Koire was a Democrat, but she understood that the takedown of America and indeed every nation of the formerly free world, would not be accomplished by the left or the right but by supranational globalists with an allegiance to no nation. In fact, these globalists detest the nation-state model that has dominated the world for thousands of years. Their goal is a “global governance” and they say it out loud in their own documents. Have no fear. Do not be intimidated. Truth will not be defeated. Humanity will prevail against these anti-human eugenicist monsters because we have living souls and are created in the image of a Holy God with individual free wills. Because of that, we humans are capable of having a personal relationship with Jesus Christ and the one and only triune God of the Bible. Those who take the bait of the globalists and submit to the world system will in essence be handing over their humanity in exchange for empty promises of safety and security. They will become trans-humans, thus foregoing, at some point, their ability to connect with God. That's a very big step and a decision that will face every human being sooner or later as this technology ramps up. Your very soul will depend on the choice you make. Will you follow God or will you follow man? Above all, this is a spiritual battle. Expose the sinister trans-humanist agenda that these globalist predators did their best to keep hidden within a scientific vernacular that they know will wow and mystify the average person. We have decoded it for you in this article from two of the best Christian experts on the topic available in the world today – Karen Kingston and Patrick Wood.   JABBED UNTIL DEATH: Endless mRNA jabs are now planned for multiple vaccine types, including influenza, HIV, RSV, Pneumococcal, Zika and many more Newstarget.com - 08/19/2022 / By Lance D Johnson Now that pharmaceutical companies like Pfizer and Moderna have caused widespread immunosuppression using covid mRNA vaccines, there will soon be a surge of new infections and a gold-rush for new mRNA vaccines. Pharmaceutical companies have already positioned themselves to capitalize on upcoming infections and illnesses that will inevitably plague an excessively immunocompromised population. Endless mRNA jabs are now planned for multiple vaccine types, including coronaviruses, influenza, HIV, leukemia, RSV, Pneumococcal, EBV, HPV, CMV, Nipah Virus, Zika, metapneumovirus and human parainfluenza. In fact, there are currently 80 clinical trials for mRNA vaccines underway, and most of these hasty clinical trials are already convincing people to take part in these experiments. Big Pharma poised to unleash mRNA experiments for multiple infections and illnesses Big Pharma is already promoting vaccines for infections that were once considered rare, like pox viruses (monkeypox) and polio enteroviruses. As new infections spread in heavily vaccinated populations, vaccine campaigns will continue their cycle of fraud and deception. The spike protein mRNA that was unleashed during the covid-19 scandal was a “foot in the door” to program human immune systems for failure (vaccine acquired immunodeficiency syndrome) and to make more people dependent on a never-ending chain of injections, infections, mandates and medical tyranny. One of the new mRNA vaccines includes an updated sequence of the gain-of-function coronavirus spike protein along with influenza virus RNA. Moderna is currently testing out an influenza-covid mRNA vaccine on 1050 participants, with recruitment taking place across the United States. Many of the upcoming clinical trials for new mRNA vaccines are set to be conducted on vulnerable populations and children, with very little oversight. The pre-clinical phase for these combo vaccines has already been approved by the FDA. Big Pharma plans to continue using these lipid nano-particles to circumvent the T-cell response of the human immune system, while programming human cells to churn out foreign toxins. It's an inflammatory, autoimmune nightmare, and it's going to continue without remorse if the developers and enforcers are not held to account for the disasters they helped create with the original covid vaccines. FDA ignores all safety signals for botched mRNA covid vaccine rollout, approves dozens of new mRNA experiments These new genetic experiments are still considered immunizations and are considered biologics in pre-clinical studies. This is fraud, because there are major differences between traditional biologics (vaccines) and these new mRNA experiments. The FDA is ignoring all previous safety signals recorded in the government's pharmacovigilance system. There are no scientific studies being conducted investigating the duration of the mRNA transcription process. Likewise, there are no studies on the quantity and persistence of these foreign proteins in animal bodies, and how they may burden distal organs, inflame the heart or cause protein misfolding. Furthermore, the toxicity of the foreign proteins themselves are not being assessed in any pre-clinical trials. To make matters worse, the vaccine makers are allowed to use the immunosuppressant pseudouridine yet again, with no pre-clinical testing on its safety. Pseudouridine is a synthetic nucleotide used in the covid-19 vaccines. Researchers found that it can stay in the lymph nodes for at least sixty days after injection. The immune system is not breaking down this so-called mRNA from the vaccines in the same way natural mRNA degrades, even though the government regulatory agencies have promised that it would degrade rapidly. To get the initial covid-19 vaccine out to the public, Pfizer and the FDA ignored serious health risks observed in the clinical trials, including issues like antibody dependent enhancement, heart inflammation and immunosuppression. These issues are obviously going unaddressed again as the government advances new experiments that will continue the cycle of sickness and death in the population.   Triple Helix DNA; The Operating Platform for the Mark of the Beast   The following is a rough transcription by Eve Brast of this video link: DNA is the code of life that gives cells the ability to function and gives organisms the ability to develop. mRNA is a tool much like a text editor that can cut, paste and edit DNA strands. We were able to engineer this as a two component system consisting of a single protein and a single RNA that provides scientists the ability to program this enzyme as a molecular scalpel to cut double stranded DNA at sights in the strand that are directed by this piece of RNA. There is a study that just came out of Lund University in Sweden that is very alarming. They have witnessed the first demonstration in a human hepatic or liver cell line of the Pfizer vaccine in fact reverse transcribes and installs DNA into the human genome. Robert Malone the inventor of mRNA technology says that there is a joint report from the government of the UK and Germany about trans humanism. This is one of the agendas of the WEF (World Economic Forum). It's not hidden and it's not a conspiracy. In these reports they talk about mRNA vaccines as an entry point [into the human body to initiate their plans for trans humanism.] A Scientist who was studying the human genome for over 25 years discovered that the human genome is a double helix and each side of the helix is made up of 72,000 genes. 72,000 from the mother and 72,000 from the father. Combined, they equal 144,000 genes total in the human genome. This is a significant number in the Bible in Rev. 7:3-4 and is a signature from God showing that we are created by Him. Now this new mRNA technology that they've come out with introduces a third strand that breaks the double helix and inserts itself, creating a triple helix and adding another 72,000 genes to the DNA strands which equals 216,000 genes. The number of the Beast is 666 or 600+60+6. Now if we multiply 600x60x6 it equals 216,000. It is evident that satan is wanting to re-create mankind in his image by adding in this third strand into the DNA of mankind. If you watch the Queen's Jubilee ceremony on 6/2/22 (=66) in the video link above, you'll see what she did. She lit up a triple helix light strand that traveled to the “Tree of trees” that was also shaped like a strand of DNA. This was symbolic of their Luciferian plans to implement the Mark of the Beast.   The Component System for the Mark Of The Beast Thomas Fulger - 10/26/22 (David's notes in red) As a born again believer I have been studying both the virus and the vaccination ingredients for two years plus now, through both a scientific, lens but most importantly, through a Biblical lens. The Mark Of The Beast is a component system based on the “Charagma” or puncture of the skin via injections.  It consists of such components as: 1.The vaccination's ingredients which are the foundational operating system. See accompanying short video: (a must)   This video below is the science of “The Mark”.  It is from La Quinta Columna and the director is Ricardo Delgado.   They have put in more than twenty thousand hours of research on the virus and the so called vaccines.  They have had their hand on the pulse of the nanotechnology factor from the beginning.   This video pretty much sums up this science with graphics and narrative.  I do not speak Spanish so I turned off the volume and watched the captions along with the pictures.  Truly amazing information! 2. 5G and possibly 6G—This is the symbiotic radiation that ties all components together 3. AI – artificial intelligence/Super Quantum computers 4. Smart phones and applications forthcoming         This component system of The Mark Of The Beast may yet utilize a computer chip implant as well as the Digital ID laws have yet to be fulfilled with a deadline of May 2023 as I understand it. This ID digitalization will also be our “passport” to making purchases.  Another method can also be used to complete the “component system' of The Beast and that is Quantum Dot Technology used as an invisible patch: Once all of these components are integrated and turned on, an individual will be a captured entity; wirelessly wedded to “the world” and not betrothed to The Lord.  Satan will have stolen your soul.  We are entering the harvest season of the last days and Satan, mimicking the Lord, is taking his harvest of souls as well. This is truly the abomination that makes the temple desolate.  As Paul points out Your body is the temple.  1 Co 6:19-20  Or do you not know that your body is a temple of the Holy Spirit who is in you, whom you have from God, and that you are not your own? 20 For you have been bought with a price: therefore glorify God in your body. My answer to Thomas: Yes, I believe almost all is known of their system and though it may have a setback with all this coming to light, it is ready for the time appointed to bring down all lost humanity who are members of the beast body already. God prophesied it and it will come to pass to gather the tares to burn them. The forced abomination that maketh desolate will come about in the middle of the Tribulation. The covenant with many is being made. The wise will be hidden in the secret place of the Most High.   Divine Protection from the Evil Seed Claire Pienaar - 9/25/22 (David's notes in red) I dreamed Riaan owned a large group of chickens. (Riaan represents the Man-Child body, as his name means “little king”.) He had appointed me as the “marketing assistant”. There were no other employees. (The Bride is the “marketing assistant” because she always promotes the Man-child, Jesus, and His business to every “chicken" who will listen.) (I likely represent the Bride body as my name, Claire, means brilliance which denotes the righteous acts of the saints, Rev. 19: 7-8  Let us rejoice and be exceeding glad, and let us give the glory unto him: for the marriage of the Lamb is come, and his wife hath made herself ready. 8 And it was given unto her that she should array herself in fine linen, bright and pure: for the fine linen is the righteous acts of the saints).(These “chickens” are a play on words. They represent the majority of Christians who are currently in the apostate religious system. They don't understand the sovereignty of God and are worried and fearful about many things. Just as Jesus came to speak to these people in His day, so He is in ours.) Three people came to Riaan in business suits and sought to use his chickens for their breeding purposes. There were two men, one younger and one older, and then a woman. (These three represent the DS international corporations who want to use the “chickens of the world” for their own trans humanist agendas. They could also represent the apostate church leadership who is in bed with the DS and seek to place their own seed into Christians.) These 3 were intent on inseminating our chickens with a strange sticky substance. They placed it onto the chicken's wings, and then they would give the chicken a shower and hope the substance would mix with the water and do the insemination. (The chicken wings represent the people's arms that the DS mRNA is injected into. Also, the chicken's wings are what help them overcome the world through flight, but when the seed of men is mixed with the water of the Word, it is powerless to enable the Christians to be over-comers.) I tried to protect all our chickens, but I was no match for these fast-moving professionals. (I really try to protect all my chickens too but some are merely called and others are elect. It's the Bride's job to try to protect God's people from the dangers of the DS in the Government and Church by countering their attempts to defile God's people.) In the dream, we easily had about 1,000 chickens all lined up in rows. Our real-life, white chicken, called Mercy was in the first row. I especially tried to protect Mercy, but they placed this sticky stuff on her wings and I was so upset. (The Mercy chicken represents those that God will have mercy on.) (I received the following verse by faith at random, Eze 39:25  Therefore thus saith the Lord Jehovah: Now will I bring back the captivity of Jacob, and have mercy upon the whole house of Israel; and I will be jealous for my holy name.) I reminded them, then, that nothing would happen because there is only one way to inseminate anything and they had done it incorrectly by placing the stuff on the chickens' wings. They were so frantic in their approach that they failed… [to cause the chickens to bear any good fruit.]. (Christians with totally corrupt DNA want to sow their seed in others. Also, the DS has gotten very sloppy because of their hubris and now their deceptions are seen. The vaccine agenda failed to kill as many people as they wanted.) Nothing gets impregnated from an external application. Then I woke up. Thank you, Lord, for protecting your people from the evil seed!!     Words Heal or Curse Your DNA Deb Horton - 10/26/11 (David's notes in red) Below are Cliffs Notes by Deb Horton of an article which reports that science has finally acknowledged that words have physical power. After removing all the New Age gobbledygook, the article acknowledges that Russian scientists have discovered that spoken words alone can and do reprogram DNA. So the tongue conquers the curse or the tongue can bring the curse. Key points quoted from the article, which is translated from German, so the terminology will sound a little strange in English (my comments in parentheses):   1. DNA can be influenced and reprogrammed by words and frequencies WITHOUT cutting out and replacing single genes. 2. The Russian linguists found that the genetic code, especially in the apparently useless 90% (which has been called "junk DNA"), follows the same rules as all our human languages...(and that) human languages ... are a reflection of our inherent DNA. 3. One can simply use words and sentences of the human language ... to influence genetic information! (i.e. agreeing with the Words that we are not under the curse, that by His stripes we were healed, etc.) This, too, was experimentally proven! Living DNA substance (in living tissue, not in vitro) will always react to language-modulated laser rays and even to radio waves, if the proper frequencies are being used. 4. This finally and scientifically explains why affirmations ...(can) repair genetic defects.(Our confessions of the positive promises of God concerning us and our circumstances change us. Death and life are in the power of the tongue. Pro 18:21  Death and life are in the power of the tongue; And they that love it shall eat the fruit thereof.) 5. ...our body is programmable by language, words and thought. This has now been scientifically proven and explained....The individual person must work on the inner processes and maturity in order to establish a conscious communication with the DNA.(i.e., 2Co. 10:5 casting down imaginations, and every high thing that is exalted against the knowledge of God, and bringing every thought into captivity to the obedience of Christ;) 6. The Russian scientists also found out that our DNA can cause disturbing patterns ....Stress, worries or a hyperactive intellect prevent (or) distort the communication (and) make it useless. (Isa. 26:3 Thou wilt keep him in perfect peace whose mind is stayed on thee.) 7.  An ordered group consciousness creates order in its whole surroundings! When a great number of people get together very closely, potentials of violence also dissolve. (Rom. 15:5 Now the God of patience and of comfort grant you to be of the same mind one with another according to Christ Jesus:. Rom. 10:10 for with the heart man believeth unto righteousness; and with the mouth confession is made unto salvation.) 8. Researchers think that if humans with full individuality would regain group consciousness, they would have a god-like power to create, alter and shape things on Earth! (That would be Christ in us, the hope of glory. Mat 18:19 Again I say unto you, that if two of you shall agree on earth as touching anything that they shall ask, it shall be done for them of my Father who is in heaven. 9. And Mar. 11:23-24 Verily I say unto you, Whosoever shall say unto this mountain, Be thou taken up and cast into the sea; and shall not doubt in his heart, but shall believe that what he saith cometh to pass; he shall have it. 24 Therefore I say unto you, All things whatsoever ye pray and ask for, believe that ye receive them, and ye shall have them. ) …   Select Language Afrikaans Albanian Amharic Arabic Armenian Assamese Aymara Azerbaijani Bambara Basque Belarusian Bengali Bhojpuri Bosnian Bulgarian Catalan Cebuano Chichewa Chinese (Simplified) Chinese (Traditional) Corsican Croatian Czech Danish Dhivehi Dogri Dutch Esperanto Estonian Ewe Filipino Finnish French Frisian Galician Georgian German Greek Guarani Gujarati Haitian Creole Hausa Hawaiian Hebrew Hindi Hmong Hungarian Icelandic Igbo Ilocano Indonesian Irish Italian Japanese Javanese Kannada Kazakh Khmer Kinyarwanda Konkani Korean Krio Kurdish (Kurmanji) Kurdish (Sorani) Kyrgyz Lao Latin Latvian Lingala Lithuanian Luganda Luxembourgish Macedonian Maithili Malagasy Malay Malayalam Maltese Maori Marathi Meiteilon (Manipuri) Mizo Mongolian Myanmar (Burmese) Nepali Norwegian Odia (Oriya) Oromo Pashto Persian Polish Portuguese Punjabi Quechua Romanian Russian Samoan Sanskrit Scots Gaelic Sepedi Serbian Sesotho Shona Sindhi Sinhala Slovak Slovenian Somali Spanish Sundanese Swahili Swedish Tajik Tamil Tatar Telugu Thai Tigrinya Tsonga Turkish Turkmen Twi Ukrainian Urdu Uyghur Uzbek Vietnamese Welsh Xhosa Yiddish Yoruba Zulu Powered by Translate Printer-friendly version

Dr. Shamez Ladhani, a pediatric infectious disease consultant at the UK Health Security Agency in London, and Sarah Gregory discuss an increase of invasive pneumococcal disease in children after the COVID-19 pandemic in England.

On episode #9 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 8/4/22 – 8/17/22.   Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Zoonotic henipavirus in febrile patients in China (NEJM) Role of prospective monitoring, pre-emptive and prophylactic therapy for human Herpesvirus-6 after stem cell transplantation (OFID) Tuberculosis outbreak in the USA linked to bone graft product (Lancet ID) Surgical and medical management of Diabetic Foot Osteomyelitis (OFID) Increase in Pediatric Intracranial Infections during COVID-19 Pandemic (CDC) Incidence of Acute Chest Syndrome in children with Sickle Cell Disease following Pneumococcal vaccine (JAMA) Antibiotic resistance genes in the gut microbiota of mothers (Nature Microbiology) Clinical characteristics, health care utilization, and outcomes among patients for Invasive Mold Disease (OFID) Low-Dose subcutaneous/intravenous Monoclonal Antibody to prevent Malaria (NEJM) Revisiting practice of the treatment of Toxoplasmic Encephalitis Phase two trial of oral fexinidazole in adults with chronic indeterminate Chagas disease (CID) Half of human pathogenic diseases can be aggravated by climate change (Nature) The Impact of standardized infectious diseases consultation on Postsplenectomy care and outcomes Potential value and patient confidentiality implications of infectious disease clinician peer consultations via social media (OFID) Music is by Ronald Jenkees

In this episode, we will discuss the rationale behind the FDA approval of two new pneumococcal conjugate vaccines (PCV20 and PCV15), the characteristics of these vaccines, their place in therapy as recommended by the ACIP, and subsequent CDC immunization schedule changes. Key Concepts Pneumococcal disease is mainly caused by various serotypes of Streptococcus pneumoniae and presentation can vary from mild forms (sinusitis, otitis media) to more severe (pneumonia, bacteremia, or meningitis). Previously we used PCV13 and PPSV23 vaccines for adults ages 18 years and older for prevention of pneumococcal disease, but the recommendations were rather complicated based on age, underlying condition/immune status, and vaccination status.  Two new conjugate-type pneumococcal vaccines, PCV20 (Prevnar 20) and PCV15 (Vaxneuvance) are now approved by the FDA and were recently added to the CDC's adult immunization schedules. These updated recommendations are more simplified where adults with high-risk conditions and those ages 65 years and older should receive either 1 dose of PCV20 vaccine or 1 dose of PCV15 and then 1 dose of PPSV23 a year later to complete their pneumococcal vaccine series.   PCV15 is now FDA approved for children and updated recommendations for children have been voted upon by the Advisory Committee on Immunization Practices (ACIP) and will be final once it is made official policy by the CDC. References and Resources Kobayashi M, Farrar JL, Gierke R, Britton A, Childs L, Leidner AJ, et al. Use of 15-Valent Pneumococcal Conjugate Vaccine and 20-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022. MMWR. 2022;71(4);109–117. https://www.cdc.gov/mmwr/volumes/71/wr/mm7104a1.htm?s_cid=mm7104a1_w Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. 14th ed. Hall E., Wodi A.P., Hamborsky J., et al., eds. Washington DC: Public Health Foundation; 2021. Goldblatt D, O'Brien KL. Pneumococcal Infections. In: Loscalzo J, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. eds. Harrison's Principles of Internal Medicine 21e. McGraw Hill; 2022. Accessed August 04, 2022. Wagner AL, Boulton ML. Pneumococcal Infections. In: Boulton ML, Wallace RB. eds. Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e. McGraw Hill; 2022. Accessed August 04, 2022. CDC's PneumoRecs VaxAdvisor mobile app: https://www.cdc.gov/vaccines/vpd/pneumo/hcp/pneumoapp.html CDC's Pneumococcal vaccine timing for adults: https://www.cdc.gov/vaccines/vpd/pneumo/downloads/pneumo-vaccine-timing.pdf

In this week's episode, we discuss the "ACR's 2022 Guideline Summary for Vaccinations in Patients with Rheumatic and Musculoskeletal Diseases" with lead author Dr. Anne Bass, Attending Physician in the Division of Rheumatology at Hospital for Special Surgery and a Professor of Clinical Medicine at Weill Cornell Medicine. During our conversation we consider the importance of guidelines for vaccines, the impact certain drugs like rituximab and methotrexate have on vaccinations, cover some vaccine highlights within the guidelines, how these guidelines can aid in navigation with insurance companies and much, much more. 

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-277 Overview: Join us to discuss a summary of the newly published guidelines for pneumococcal vaccines and to review the most recently approved vaccines. We'll begin by describing the challenges from the previous guidelines and how these new guidelines address these challenges. Given the burden of pneumococcal disease and that vaccination is our best weapon to combat the disease, you won't want to miss this episode.  Episode resource links: Morga, A., Kimura, T., Feng, Q., Rozario, N., & Schwartz, J. (2022). Compliance to Advisory Committee on Immunization Practices recommendations for pneumococcal vaccination. Vaccine.   https://www.medscape.com/viewarticle/967675#vp_1   Schulz, P. S., Moore, S. E., Smith, D., Javed, J., & Wilde, A. M. (2022, April). Missed Pneumococcal Vaccination Opportunities in Adults With Invasive Pneumococcal Disease in a Community Health System. In Open Forum Infectious Diseases (Vol. 9, No. 4, p. ofac075). US: Oxford University Press.   Center for disease Control and Prevention Resources: App for iphone and android PneumoRecs Guest: Mariyan L. Montaque, DNP, FNP-BC   Music Credit: Richard Onorato

Continuing on with our 2 month vaccines according to the CDC schedule, we are diving into the pneumococcal vaccine and all the the things regarding this disease, the vaccine, the ingredients, the side effects and more.One of the most common causes for irritability in babies comes from this vaccine, that MANY parents don't even realize are being given to their children.Informed consent is SO So important! Subscribe and hang out with me every Wednesday to stay up to date on this show.  If you enjoy, please share this on your social media and tag me (@brookebrewer20) and give me a rating/review. Thank you!For Text updates when each episode releases textPODCAST to (248) 301-9919 Sponsors:Get your Fat Burning Collagen today (linked the chocolate flavored goodness)https://modere.co/3jxbzyBUse code 4842132 to save $10 off your first orderShow notes and references: Current CDC Vaccine Schedulehttps://www.cdc.gov/vaccines/schedules/index.htmlFDA website for package inserts: https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htmVaccine Ingredient Summary https://vaccine.guide/vaccine-ingredients/overview/cdc-vaccine-excipient-and-media-summary/Vaccine Glossery and Detailshttps://vaccine.guide/vaccine-ingredients/overview/vaccine-ingredient-glossary-and-details/Harvard Study on VAERS reporting https://vaccine.guide/ncvia-vicp-vaers/vaccine-adverse-events-reporting-system/hhs-funded-vaers-investigation/Pneumococcal Diseasehttps://www.cdc.gov/pneumococcal/index.htmlPrevnar13 Inserthttps://vaccine.guide/vaccine-inserts/pneumococcal/prevnar-13/The vaccine conversationhttp://www.thevaccineconversation.com 

Researchers look to licorice for promising cancer treatments   University of Illinois Chicago, April 6, 2022   Licorice is more than a candy people either love or hate—it may play a role in preventing or treating certain types of cancer, according to researchers at the University of Illinois Chicago. Gnanasekar Munirathinam and his research team are studying substances derived from the licorice plant Glycyrrhiza glabra to determine if they could be used to prevent or stop the growth of prostate cancer. "When we look at the research out there and our own data, it appears that glycyrrhizin and its derivative glycyrrhetinic acid have great potential as anti-inflammatory and anti-cancer agents," Munirathinam said. "We hope our research on prostate cancer cells advances the science to the point where therapies can be translated to help prevent or even cure prostate and other types of cancer."   (NEXT)   Not all dietary fiber is equal: Cereal fiber linked with lower inflammation, but not fruit or vegetable fiber   Columbia University, April 6, 2022   Researchers at Columbia University Mailman School of Public Health and colleagues evaluated whether dietary fiber intake was associated with a decrease in inflammation in older adults and if fiber was inversely related to cardiovascular disease. The results showed that total fiber, and more specifically cereal fiber but not fruit or vegetable fiber, was consistently associated with lower inflammation and lower CVD incidence. The research confirmed previously observed associations between dietary fiber and CVD and extended those investigations to include the source of the fiber, the relationship of fiber with multiple inflammatory markers, and to test whether inflammation mediated the relationship between dietary fiber and CVD.   (NEXT)   How to reduce loneliness: Meaningful activities can improve health, well-being   Pennsylvania State University   Free time is sometimes idealized, but research shows free time can sometimes be unhealthy by increasing loneliness. A new Penn State study demonstrated that engaging in meaningful, challenging activities during free time can reduce people's loneliness and increase their positive feelings. Across two different studies, the researchers found that people who had meaningful, challenging experiences were less lonely—even when higher levels of social contact and support were not available. Our research shows that both of these ideas are true. By engaging in meaningful activities during free time that demand focus, people can reduce loneliness and increase momentary happiness."  "Loneliness is very connected to our health," Dattilo explained. "Psychological, emotional, and cognitive health are all challenged when people are lonely. Loneliness is associated with depression and other mental health challenges."   (NEXT)   Curcumin Found To Outperform Pneumococcal Vaccines In Protecting Infants   UCLA, April 1, 2022   Now new research finds a substance in turmeric, curcumin, may outperform the vaccine in providing long lasting protection against potentially deadly lung damage in infants. Pneumococcal bacteria are the most common cause of bacterial infections in children and a frequent cause of infections in adults. Infection starts in the nose or throat where it may persist for weeks or months. Pneumococcal infections are also the most common complication of seasonal influenza. Researchers at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), using disease models, found curcumin provided long-term protection against the damage caused by inadequate lung function. Their study, published online by the American Journal of Physiology, Lung Cellular and Molecular Physiology, found curcumin provided protection against bronchopulmonary dysplasia (BDP), a condition characterized by scarring and inflammation, and against hyperoxia, in which too much oxygen enters the body through the lungs.   Scott Ritter   via ZOOM   Scott Ritter is a former US Marine Corp intelligence officer and military strategist during the Cold War with the Soviet Union and in the Middle East. He served as a lead analyst for Marine deployment during the Soviet invasion of Afghanistan and the Iran-Iraq war. During Operation Desert Storm, Scott was the ballistic missile advisor to General Schwarzkopf. Later he assumed the role of the lead United Nations weapons inspector for seven years overseeing the disarmament of Iraq's weapons of mass destruction and biological agents program. He was one of the most forceful critics of the Bush administration's claims that Sadaam Hussain possessed WMDs. Scott is now an author and lecturer who has been very public about the American media's misinformation campaign about Russia's incursion into Ukraine and the gross failure's of the Biden White House foreign affairs policies and actions.