Podcasts about Powells

Ik was enigszins verbaasd over de forse reactie op de Amerikaanse beurzen op het nieuws dat Donald Trump Jerome Powell wilde ontslaan. Aandelen daalden met 2,5% en daar kwam voor ons eurobeleggers nog eens een 1% dollardaling bovenop. Het verbaast me, omdat Trumps mening niet nieuw is. Hooguit dat zijn tweet, of hoe je een bericht op zijn eigen sociale mediakanaal ook noemt, grof en heftig was. Maar dat zijn we zo langzamerhand wel gewend. Sommige economische commentatoren gaven aan dat de Amerikaanse president de Fed-voorzitter niet zal ontslaan, omdat dat wel heel dom zou zijn. Dat klopt, maar dat is geen argument meer, zo hebben we in de afgelopen drie maanden geleerd. De belegger van vandaag moet simpelweg rekening houden met een hoge mate van wispelturigheid. En inderdaad: slechts één dag na de koersdaling zei Trump dat hij niet de intentie had om Powell te ontslaan. Gelukkig kan Mr. Market Mr. Trump nog een beetje in toom houden. Waarom is een onafhankelijke Fed eigenlijk belangrijk? Die kan onplezierige beslissingen nemen, zoals de rente verhogen. Wil je te hoge inflatie bestrijden, dan is een renteverhoging een goed stuk gereedschap. Dat is geen prettig besluit, zeker niet als je, zoals de Amerikaanse overheid, veel schulden hebt. Diverse opkomende markten gingen al eens de kant van een veel te soepel monetair beleid op. Die weten dat vertrouwen van de financiële markten terugwinnen een moeilijke en pijnlijke weg is. Turkije en veel Zuid-Amerikaanse landen zouden een afschrikwekkend voorbeeld moeten zijn. Misschien hebben Trump en de Turkse president Erdogan samen hetzelfde vak gevolgd: ‘economie voor populisten’. De grootste verbazing zit misschien nog wel in het feit dat men zich er nu zo druk om maakt. Powells termijn eindigt al in mei 2026. Wie neemt dan zijn voorzittershamer over? Als je kijkt wie Trump in zijn regering heeft benoemd, geeft dat weinig vertrouwen. Er is een reële kans dat het een soort trekpop wordt die naar his master’s voice luistert. Beleggers hebben zo te zien wat moeite om risico’s die over een jaar plaatsvinden, in te schatten. Waarschijnlijk wordt de beoogde opvolger al in het najaar aangewezen. Omdat het fundament van de Amerikaanse staatschuld en de dollar gebaseerd is op vertrouwen, is een betrouwbaar boegbeeld bij de centrale bank erg belangrijk. Powell vervult die rol met verve. Grote kans dus dat dat vertrouwen over een jaar bij zijn afscheid flink op de proef wordt gesteld. Ik zou dus wat langer vooruitkijken dan die ene dag waarop beslissingen van de Amerikaanse president genomen kunnen worden of juist weer ingetrokken. Ik hoop dat Mr. Market een permanente zetel in de Oval Office krijgt. Nu Elon Musk het Witte Huis gaat verlaten, is er nog wel een plekje vrij. Over de column van Corné van Zeijl Corné van Zeijl is analist en strateeg bij Cardano en belegt ook privé. Reageer via c.zeijl@cardano.com. Deze column kun je ook iedere donderdag lezen in het FD.See omnystudio.com/listener for privacy information.

Chris talks with Dr. A. Michael Powell and Shirley Powell about their authoritative work in Trans-Pecos botany and Dr. Powell's role in recognizing and formally describing Ovicula biradiata, or "Wooly Devil," a previously unknown genus of plant recently discovered in Big Bend National Park.The find generated a spate of high-profile new headlines, such as this one from the Smithsonian magazine:https://www.smithsonianmag.com/smart-news/meet-the-wooly-devil-the-first-new-plant-genus-discovered-in-a-national-park-since-1976-180986117/Chris and the Powells also talked about Dr. Powell's many books on the flora of the larger Big Bend region, and their work in the herbarium at Sul Ross State University. This scientific collection of plant specimens is the fourth largest in the state.

Jeff and Rebecca debrief a little about their live recording at Powell's last week before talking about Meta Streisanding itself, the exciting/scary news of Scorsese's for actual life Gilead adaptation, and more of the week's book news. Subscribe to the podcast via RSS, Apple Podcasts, and Spotify. Sign up for the Book Riot Podcast Newsletter and follow the show on Instagram and Bluesky. Get more industry news with our Today in Books daily newsletter. Trust your reading list to the experts at Tailored Book Recommendations who have recommended over 160,000 books to readers of all kinds. Let TBR match you with your next favorite read! Get started for only $18 at mytbr.co! Discussed in this episode: Scorcese! Adapts! Gilead! Series! Austin Butler & Saoirse Ronan to star in Deep Cuts adaptation Moms for Liberty is shutting down BookLooks  Former Meta executive ordered to halt promotion of tell-all book Spotify launches program to publish audiobooks for independent authors WNDB announces first We Need Diverse Books Day April 3 Careless People White Light by Jack Lohmann We Tell Ourselves Stories by Alissa Wilkinson The Book Riot Podcast Patreon The Book Riot Podcast Newsletter The Book Riot Podcast on Instagram Learn more about your ad choices. Visit megaphone.fm/adchoices

Like so many families, Eric and Diana Powell entered into adoption with the best intentions. After their first international adoption from Thailand, they quickly started the paperwork for their second, knowing that the process is often long and fraught with delays. What they couldn't know is that the next few years of their adoption journey would include physical aggression, episodes of emotional dysregulation, marriage tension, a phenomenon known as “blocked care”, and an overwhelming sense of isolation. During this challenging period, they often didn't know where to turn next or what to do to help their family heal and connect. Blocked care is a response that can occur when a person rejects your attempts to provide for them, no matter how loving or compassionate those attempts may be. Over time, this pattern can lead to feelings of rejection, hostility, anxiety, and even compassion fatigue in the caregiver. Eric and Diana's story has been one of incredible challenges, but it is also one of tremendous growth. Today, the Powells are passionate about being a listening ear for others on their fostering or adoption journey. In this episode, they explain how they learned what blocked care is and how to navigate it, the importance of finding a supportive community as a foster or adoptive parent, where to find hope when reality doesn't match your expectations, and much more. Find resources mentioned and more in the show notes for this episode: https://theforgotteninitiative.org/eric-diana-powell-265/

I denne uge skal du lære to nye finansudtryk, som selvfølgelig har noget med Trump at gøre, og som er ganske afgørende i den nuværende situation på aktiemarkedet. Vi runder også den amerikanske forbruger med detailsalgsdata mandag, hvilket kan blive ugens vigtigste begivenhed fordi der er lidt begyndende vækstnervøsitet omkring USA's økonomi. På Fed-mødet onsdag er der mest fokus på de økonomiske forecast og Powells udtalelser. Kan der spores noget vækstnervøsitet og begynder toldforhøjelser at spille ind i inflationsforecastet?

On this episode, Rebecca Schinsky and Jeff O'Neal of Book Riot sit down and talk to me about their reading lives. We talk about their professional work in the world of books, how Oliver Burkeman would feel about my bad bookish habit, and how any book can be interesting if you're curious enough.    Listen to the Book Riot Podcast  Listen to First Edition Better Living Through Books Newsletter (and the rest of the Book Riot Newsletters!)  Jeff and Rebecca Live at Powells!   Books mentioned in this episode:    What Betsy's reading:  B.F.F.: A Memoir of Friendship Lost and Found by Christie Tate  Tomorrow, and Tomorrow, and Tomorrow by Gabrielle Zevin  Madwoman by Chelsea Bieker   Books Highlighted by Rebecca & Jeff: Sula by Toni Morrison  The Remains of the Day by Kazuo Ishiguro  The Sparrow by Mary Doria Russel The English Understand Wool by Helen DeWitt  Lab Girl: A Memoir by Hope Jahren  Matterhorn by Karl Marlantes  We Ride Upon Sticks by Quan Barry The Street by Ann Petry How to Be Perfect: The Correct Answer to Every Moral Question by Michael Schur The Orchard: A Memoir by Adele Crockett Robertson Four Thousand Weeks: Time Management for Mortals by Oliver Burkeman  When Women Were Birds: Fifty-Four Variations on Voice by Terry Tempest Williams  Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity by Kim Scott  Conscious Business: How to Build Value through Values by Fred Kofman    All books available on my Bookshop.org episode page.   Other books mentioned in this episode: Post-Traumatic by Chantal V. Johnson  House of Cotton by Monica Brashears  Sipsworth by Simon Van Booy  Onyx Storm by Rebecca Yarros  Where the Crawdads Sing by Delia Owens Ingrained: The Making of a Craftsman by Callum Robinson  Cabin: Off the Grid Adventures with a Clueless Craftsman by Patrick Hutchinson  Life in Three Dimensions: How Curiosity, Exploration, and Experience Make a Fuller, Better Life by Shigehiro Oishi  Meditations for Mortals: Four Weeks to Embrace Your Limitations and Make Time for What Counts by Oliver Burkeman  Ender's Game by Orson Scott Card  The Hobbit: Or There and Back Again by J.R.R. Tolkien  The Shining by Stephen King  Never Let Me Go by Kazuo Ishiguro  My Brilliant Friend by Elena Ferrante  Fourth Wing by Rebecca Yarros  It Ends with Us by Colleen Hoover  All Fours by Miranda July  Passing by Nella Larsen

Jerome Powell at FOMC meeting is feeling the pressure to admit defeat to bitcoin SPONSORS ► Bitcoin Well: bitcoinwell.com/simplybtc ► Passport by Foundation: foundation.xyz/simply ► Compass Mining compassmining.io ► Stamp Seed: www.stampseed.com PROMO CODE: SIMPLY for a 15% discount ► HIVE Digital Technologies: hivedigitaltech.com ► BitBlockBoom: bitblockboom.com PROMO CODE: “bbb21” for $100 off FOLLOW US ► https://twitter.com/SimplyBitcoinTV ► https://twitter.com/bitvolt ► https://twitter.com/Optimistfields ► Nostr: npub1vzjukpr2vrxqg2m9q3a996gpzx8qktg82vnl9jlxp7a9yawnwxfsqnx9gc JOIN OUR TELEGRAM, GIVE US A MEME TO REVIEW! ► https://t.me/SimplyBitcoinTV SUBSCRIBE TO OUR YOUTUBE ► https://bit.ly/3QbgqTQ SUPPORT US ► On-Chain: bc1qpm5j7wsnk46l2ukgpm7w3deesx2mdrzcgun6ms ► Lightning: simplybitcoin@walletofsatoshi.com #bitcoin #bitcoinnews #simplybitcoin DISCLAIMER: All views in this episode are our own and DO NOT reflect the views of any of our guests or sponsors. Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. If you are or represent the copyright owner of materials used in this video and have a problem with the use of said material, please contact Simply Bitcoin.

In this week's episode the Powells discuss the the first week of the  #Trumppresidency and th flurry of #racist #executiveorders. More companies are scrubbing their #DEI programs including #Target and other retailers. The only solution is to economically boycott those companies that don't have your best interests in mind. #project2025 is in effect. The #constitution is under assault. A #ChristianNationalist agenda is the plan. Buckle up. In sports the #KansasCityChiefs will face the #PhiladelphiaEagles . #PatMaholmes facing #JalenHurts and #SaquanBarkley in the #SuperBowl

In this episode, the Powells are joined by long lost Powell. Mark rejoins the podcast to discuss the lie that has become America. America isn't a nation of laws where #Justice is blind . #Trump has been made a #king by the #SCOTUS . We no longer wear the white hat. We are the bad guys now. The #LosAngelesFires  are discussed as a failure of leadership instead of a feature of #GlobalWarming. The #NevadaBombing #BourbonStreet tragedy are all no longer newsworthy as the #TrumpAssasination was never really investigated. #AndrewCuomo is making a comeback as he plans to run for #MayorOFNYC . #MikeTomlin may be done as #PittsburgSteelers head coach and #JaydenDanials is a revelation for the #WashingtonCommanders in the #NFLPlayoffs

S&P Futures are positive this morning with multiple catalysts ahead. The key economic event today will be the FOMC announcement on monetary policy where a 25-basis point cut is expected. The latest dot plot data will be released which will likely show fewer and slower rate cuts in 2025. Powells press conference will likely be a source of market volatility. Congressional leaders reached a deal on government funding. Earnings reports after the bell today from MU, LEN, MKLN & SCS. Honda and Nissan are said to be exploring a merger. Post Holdings announces a deal for Potato Product of Idaho making a deal for Lamb Weston unlikely. Mastercard unveils new $12B stock buyback program. In Europe stocks trading higher and oil prices are displaying gains as the EU & the UK place sanctions tankers being used to transport Russian oil.

In this week's holiday preview the Powells share their thoughts on the last days of 2024. As we head into the holidays we learn that #Trump may pardon #SwaggyE , #MayorAdams for his criminal activity. We learn that for some (not the #Rockerfeller drug convicts) the legal #cannibis business in #NYC has reached a billion in sales. Crime pays when its not a crime. The U.S. problem  of #schoolshootings contiues unabated. The #AbundantLifeChristianSchool was the scene of the latest uniquely #AmericanTragedy. #MadisonWisconsin is on the map for the wrong reasons. #TravisHunter is the #2024HeismanTrophy winner. #CoachPrime has two potential top ten picks in the upcoming #2025NFLDraft . #ShadeurSanders is likely to be a top ten first round pick alongside #ColoradoBuffaloes teamate Hunter. #NYCMinimumWage is up to $16.50 an hour . Good news for kids getting their first jobs. We would like to wish you all a #MerryChristmas and a safe and prosperous #NewYear.

In this week's  post Thanksgiving episode the guys share their thoughts on the realities of the coming Trumpocalypse . #Walmart has decided they're done with #DEI for ....reasons. The Powells hope to convince you to use your #buyingpower to affect #change. In fact we suggest that you use the #GoodsUniteUsApp to buy from those that support you and your beliefs. Derek is surprised to learn that #KrispyKreme may be off the menu . Sacrifices must be made.Speaking of sacrifices, #Diddy was denied bail again . Good, he sacrificed any goodwill for his own demons. We hope that you all had wonderful #Thanksgiving . Remember that #PowelltothePeople will be #RebelBase1 providing you with content and entertainment for a dystopian #America #Lowes #HomeDepot #GoodsUniteUs #DunkinDonuts #family 

Adam Recap's Saturday's games: Powells heroics, Pistons scare Celtics --- Join the Fantasy Basketball International community for free via our website - www.fbi-basketball.com --- Buckle up and get ready to talk fantasy basketball! Join Adam King as he takes you on a journey through the 2023-24 NBA season. --- Become a member of the Fantasy Basketball International community for free, and gain a competitive edge. --- Interact with fellow managers on Discord at http://discord.gg/YbvGS98bwC. Subscribe to our YouTube channel for weekly episodes packed with insights and expert advice https://www.youtube.com/@FBIBasketball. --- Intro credit: All I Need - Anfa Rose & Manu Crooks

In this week's episode the Powells discuss the devastating #climatechange #globalwarming induced #hurricanes affecting #Florida #Georgia #NorthCarolina and parts of #Appalachia. Last week #HurricaneHelene slammed into the southeast causing widespread damage and #stormsurge. This week #HurricaneMilton has #Tampa in its bullseye. #Category5 hurricanes are becoming a niorm. #VoteBlue ! #VoteEarly Climate change is real. Other topics covered include more fallout from #MayorEricAdams #corruption . #DeputyMayorPhilBanks has resigned. We say goodbye to #JohnAmos #CissyHouston and #KrisKristopherson . More #Diddy news. Former New York Governor #DavidPatterson was in the news. #NewEnglandPatriots safety #JabrillPeppers is in the news for the wrong reasons

Talking about our trip to see AC/DC, my talk to the Withiel WI, being made patron of the John Betjeman Centre and more from the Powells. 

Fed-baas Jerome Powell zal geen al te fijne herinneringen over hebben gehouden aan zijn bezoek aan Amsterdam, vorige week: hij bleek corona te hebben opgelopen en hoewel dat inmiddels geen reden meer is voor paniek, was het ongetwijfeld een smetje op zijn bezoek. Hoe anders was dat voor macro-econoom Edin Mujagic, die aan Powells lippen hing. Zeker toen hij ging uitleggen waarom het de Amerikaanse economie zo voor de wind gaat, sinds het einde de coronacrisis.   See omnystudio.com/listener for privacy information.

Fed-baas Jerome Powell zal geen al te fijne herinneringen over hebben gehouden aan zijn bezoek aan Amsterdam, vorige week: hij bleek corona te hebben opgelopen en hoewel dat inmiddels geen reden meer is voor paniek, was het ongetwijfeld een smetje op zijn bezoek. Hoe anders was dat voor macro-econoom Edin Mujagic, die aan Powells lippen hing. Zeker toen hij ging uitleggen waarom het de Amerikaanse economie zo voor de wind gaat, sinds het einde de coronacrisis.   See omnystudio.com/listener for privacy information.

Liz announces her "Lizness Not Business" plan for 2024-25: She's been accepted as a Fellow in Stanford University's Distinguished Careers Institute. On this new episode, she answers Julie and Lian's questions about the program and why she decided to make a big move this fall. You can also check out the program here. https://dci.stanford.edu/. Liz's 2024-25 DIC cohort is listed here: https://www.linkedin.com/school/stanford-dci/ Lian added a couple of special Satellite Sisters Meet-Ups on her book tour. On June 3 in Portland, there will be a no-host meet-up at McMenamins Cedar Hills not far from Powells Cedar Hills from 5:30 to 6:30 before her appearance at 7. Monica and Liz will both attend the meet-up and Powells. Woo hoo! Then in Santa Fe on June 23, there will be a book discussion, wine and mingling at Chomp https://www.chompsantafe.com/ in the Community Loft. Complete details for all events on Lian's website. In other news on this podcast episode, Julie reviews the details of her Regional Family Meeting in Bend, Oregon and the difference one Carvel ice cream cake can make and has a special shout-out for the crew and passengers of American Airlines #530 - we love your new DFW - RDM service! Liz recommends not just season 3 of Hacks on Max but the official podcast about Season 3: https://youtu.be/KOFFlCL-hUY?si=V8SlLcydaXx_HsKN Plus Pole Pedal Paddle happens in Bend, Oregon this weekend, a quintessential Bend athletic event that combines Alpine skiing, Nordic Skiing, biking down the mountain, running through dirt trails, paddling along the Deschutes River and a final sprint to the finish. https://www.bendsource.com/outside/from-the-mountain-to-the-river-embracing-bends-iconic-pole-pedal-paddle-tradition-21120015 Thank you to our sponsors and to listeners for using these special urls and codes to support them: Prose https://prose.com/sisters Framebridge https://framebridge.com Butcher Box https://butcherbox.com/sisters Use code sisters at checkout Osea https://oseamalibu.com Use code satsisters at checkout  New 2024 Satellite Sisters episodes to download: Fitness and Aging with guest Liz Neporent. 3/12/24 Colon Cancer Diagnosis, Treatment and Lessons Learned. 3/19/24 Women's Wellness Through Transitions like Menopause with MEA 3/26/24 Information about MEA Workshop Lian is attending in June: A Lifetime of Women's Wellness: Thriving Through Transitions with Dr. Suzanne Gilberg-Lenz The Marriage Sabbatical Pub Day Book Talk by Lian Dolan. No spoilers on this episode! 4/2/24 Lian Dolan's books: For information on Lian's novels, including The Marriage Sabbatical, her latest book out now, please visit liandolan.com Join our community: Facebook Page, Facebook Group and on Instagram and Twitter @satsisters. Visit the Satellite Sisters website here: https://satellitesisters.com Visit + subscribe to the Satellite Sisters YouTube channel here: https://www.youtube.com/@satellitesisters7265 Shop the Satellite Sisters store here: https://satellite-sisters-shop-5893.myshopify.com/collections/all Email Satellite Sisters at hello@satellitesisters.com. Follow Lian Dolan on @instagram @liandolan Follow Liz Dolan on @instagram @satellitesisterliz Follow Julie Dolan on @instagram @julieoldestsister Learn more about your ad choices. Visit megaphone.fm/adchoices

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we feature songs from Authentic Unlimited, The Powells, Eddie Sanders, Chosen Road and many, many more. This program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes to mention a few select sources for access to radio stations all across the globe.

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we feature songs from Authentic Unlimited, The Powells, Eddie Sanders, Chosen Road and many, many more. This program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes to mention a few select sources for access to radio stations all across the globe.

Geneveive lies to her new boyfriend about her age, much to Zoila's dismay. Rosie begins working at the Powells. Carmen learns Odessa is hiding something. Marisol goes with Taylor to a fertility clinic. --- Support this podcast: https://podcasters.spotify.com/pod/show/mo-sisco/support

In this week's episode the Powells learn that 3 of them are Generation Jones.  Say What? You heard , #GenerationJones AKA #BabyBoomer2 ./ The conversation continues with a discussion of the recent nuptuals of #cojoinedtwin #AbbyHensel. No coment from #BrittanyHensel . We say good bye to the late great #LouGossettJr . #MarchMadness continues with a showdown between #CaitlinClark and #Iowa vs #AngelReese and #LSU. Other topics #RasheeRice #KansasCityChiefs #JoelEmbid

How can patients and their families become more integral in the clinical research process? How can patient-led research become more accepted in the scientific community? How are inspiring groups forging new, collaborative paths for science and medicine, and reshaping how medical research is conducted?  We will tackle those questions and much more in this episode with Amy Dockser Marcus, a Pulitzer Prize-winning journalist and author of the recently published book, “We the Scientists: How a daring team of parents and doctors forged a new path for medicine.” Amy is a veteran reporter at the Wall Street Journal and won her Pulitzer Prize for Beat Reporting in 2005 for her series of stories about cancer survivors and the social, economic, and health challenges they faced living with the disease. She has covered science and health at the Journal for years, and she also earned a Masters of Bioethics from Harvard Medical School.  -------------------------------------------------------- Episode Transcript: 00;00;00;00 - 00;00;24;19  How can patients and their families become the centers of research? What is open science and who are citizen scientists? We'll explore those questions and more on this episode of Research and Action in the lead in. Hello and welcome back to Research and Action, brought to you by Oracle Life Sciences. I'm your host, Mike Stiles, and our guest is Amy.     00;00;24;19 - 00;00;48;22  Dr. Marcus That's right, that Amy Marcus, the Pulitzer Prize winning journalist, reporter at the Wall Street Journal, a Pulitzer Prize, was won for her series of stories in 2005 about cancer survivors and the social and financial challenges of living with cancer. Her beat, as you would imagine, has long been science and health. And she holds a master's of bioethics from Harvard Medical School, and she's an author.     00;00;48;22 - 00;01;04;26  Her book is We The Scientists How a Daring Team of Parents and Doctors Forged a New Path for Medicine. So this should be interesting as we talk about collaborative, open science and the rise of citizen scientists and patient led research. So thanks for being with us, Amy.     00;01;05;01 - 00;01;06;22  I'm happy to speak with you today.     00;01;06;22 - 00;01;26;29  Great to have you. In your new book, you take readers through some really, frankly, heart wrenching experiences that patients and their families have gone through with a rare and devastating disease called Niemann-pick. Hopefully I'm pronouncing that correctly. Tell us about the book and that disease and what fascinated you about this story.     00;01;27;14 - 00;02;01;21  The origin of the book really is a personal story, which is my mother got diagnosed with a rare type of cancer. And when I tried to do research on her behalf, I started to learn how challenging it is to develop drugs for rare diseases. After she passed away, I took some time off from the Journal. I had a research grant from the Robert Wood Johnson Foundation and I started traveling around the country looking to see if there were new models that might accelerate drug discovery.     00;02;01;29 - 00;02;25;21  And during the course of that research, I was introduced to a group of parents whose children have this rare and fatal genetic disorder, NIEMANN-PICK type C disease. It's a cholesterol metabolism disorder, so the cholesterol doesn't get out of the lysosome and that compartment in the cell and it starts to build up and it causes all kinds of problems.     00;02;25;21 - 00;02;52;12  And the children eventually lose the ability to walk and to talk and to feed themselves. But the parents that I met wanted to do something novel. They had found a group of scientists and researchers and clinicians and even some policymakers in the government that wanted to work together as partners and to see if they could accelerate the search for a cure or an effective therapy for an epic disease.     00;02;52;19 - 00;02;58;11  And they let me follow along during the course of that partnership for over ten years.     00;02;58;24 - 00;03;05;24  That's amazing that you got that kind of insight. And what did you learn over the course of that ten years?     00;03;06;22 - 00;03;34;15  Well, I was really interested in how they saw the production of science in a different way. They all wanted to try to save or extend the children's lives The disagreements lay in. How do you go about prioritizing drugs? What amount of risk is a patient or a patient's family willing to take compared to the level of risk that a doctor or scientist wants the patients to take?     00;03;34;15 - 00;03;54;14  These sorts of tensions arose, I think, in part because they were modeling a new method of where the patients expertise was considered as valuable or even at the center of this of this project. And that's not usually how it is.     00;03;54;14 - 00;04;09;09  But that's rare, right? I mean, in our in the culture of our health care system, it's not really common that the patients input or the patients families input is invited at all.     00;04;09;19 - 00;04;34;11  Yeah, I think that that you're right about that. I mean, the traditional way of setting things up is that the scientists devise the hypotheses and they then construct trials in conjunction with clinicians and sometimes with pharmaceutical companies, of course. But in this particular collaboration that I was describing, the drug was not in the hands of a pharmaceutical company.     00;04;34;11 - 00;04;59;06  It was widely available. And so the partnership was truly about, you know, going to be conducted at the NIH. And therefore it gave the parent and the families, I think, more leeway to do this experimental idea. What if we all recognized each other's expertise? What if we all saw each other as equal partners? What if we got to weigh in?     00;04;59;13 - 00;05;20;24  Not in once. You've already set up the clinical trial, but at the very, very outset, when you're simply going through the scientific literature to come up with potential compounds, when you're thinking about what might work, when you're trying to prioritize what to do first, second and third, all of those things where patients don't always have a voice. But in this case they really did.     00;05;21;07 - 00;05;43;16  You know, we just had Hilary Hannah Ho on the show. She's secretary general of the Research Data Alliance, and we talked about open science and open data and how important all that is to getting the scientific breakthroughs that will actually help people and get to those breakthroughs faster. But open science can kind of be polarizing. There's some confusion around what exactly it means.     00;05;43;23 - 00;05;48;14  How would you define or describe open science and citizen scientists?     00;05;48;27 - 00;06;34;22  Yeah, I think that's a really good point, that there isn't one sort of accepted name and that there are many names and people use different phrases when they're thinking about different things. For me, I used the term patient LED research and I often use the term citizen science. And what I meant by that was, again, what we've been talking about from the outset, which is a recognition that the patient, the patient experience should be at the center of everything, a recognition that the patient and the families are experts, that they have the ability not only to be beneficiaries of scientific knowledge, but also creators of scientific knowledge.     00;06;34;27 - 00;06;46;15  And to me, that shift the idea that you can be a creator of scientific knowledge is the fundamental one that needs to happen if we're going to really reach the goals that I think we all want to reach.     00;06;46;29 - 00;07;11;10  So here's something we highlighted in your book. Quoting here Science is inherently a social enterprise. Yet too often scientists operate behind closed doors, removed from the very people they intend to help. That's struck me as kind of a mike drop statement with a lot of truth to it. But did the pandemic change anything? Was the work still removed from those patients on ventilators and ICU?     00;07;11;20 - 00;07;52;04  So I do make a point in the book to draw some parallels between the various patient led research movement experiences that I describe and the COVID 19 pandemic, and in particular the group of patients that call themselves long COVID patients, where they're suffering symptoms for many, many months. I argue that COVID allowed us in real time to to recognize that anyone can be an expert and that now that is something that it was easier to see during the pandemic because there was a novel virus, there weren't established experts yet.     00;07;52;14 - 00;08;25;28  And so while doctors and scientists and the government were scrambling to try to help patients, I think they also saw themselves for the first time as part of this effort to understand the disease. Together, there wasn't already an understanding of COVID 19. And so what I say in the book is that we can draw from from that experience and sort of take that part of it forward where we say patients should be at the center of things.     00;08;26;06 - 00;09;07;01  Patients are experts. Patients are able to identify things that many scientists or doctors didn't have time to recognize because they were they had to focus on trying to save lives and, you know, working in a vacuum at that point. So there also was a sense of urgency. Like one of the things that I was struck by during the pandemic as a as a science reporter was that scientists were able to put their papers online right away on these websites before it had gone through the full peer review process because it was recognized is so essential to get this information out there as quickly as possible.     00;09;07;09 - 00;09;29;16  And everyone understood that maybe there were going to be some mistakes. It wasn't fully vetted, but it was out there. Not only was it publicly available to the doctors and scientists who are also studying it, it was publicly available to patients and people who are simply interested. And long COVID patients organized themselves, did research on themselves, and they also published their papers on these websites.     00;09;29;16 - 00;09;43;22  I think those types of models where patient researchers can be contributors and can benefit from the information to fuel their own research, I think that should move forward and is it shouldn't be just a relic of the COVID 19 pandemic.     00;09;44;07 - 00;10;05;03  But what isn't there a risk of chaos a little bit? Because we're always told, hey, whatever condition you have, don't go Googling it on the Internet. You'll just go down a rabbit hole and, you know, worry about all these conditions that you may or may not have. So what is the risk of, like you said, mistakes and wrong information being published?     00;10;05;13 - 00;10;27;11  Well, even the traditional peer review process in science publishes papers that turn out to have mistakes in them. Papers are retracted all the time. And there is a well-known phenomenon that peer reviewed papers sometimes the results can't be replicated. I mean, that's the problem for science. I don't think that's a problem just for having patient researchers get involved.     00;10;27;28 - 00;10;54;27  I also think that the advice not to Google something is both old fashioned at this point and probably unrealistic given that almost all of us are connected in some way through the Internet. My sort of idea, rather, is that let's use the Internet and other methods to become better partners. Let's share good quality information online that people have access to.     00;10;55;06 - 00;11;20;20  Let's form partnerships where we can collaborate, where among experts, the people that I was talking to and interviewing and spending time with the parents, they weren't saying, Hey, we're trying to go it alone. We know everything. No, the opposite. What they were saying is we have very relevant and valuable information. We are experts because we live with this disease and we know what level of risk we're willing to tolerate.     00;11;20;20 - 00;11;43;28  And we do our own research. But we need partners who can also help us fill the gaps where we don't have knowledge. We want to collaborate with scientists, we want to collaborate with clinicians treating our children. We want to collaborate with government scientists who have access to data and and robots and things that we're not going to have in lab equipment that we don't have access to.     00;11;44;06 - 00;12;02;19  So no one's saying, go down a rabbit hole by yourself. What people are arguing is let's find ways to pool information, and by pooling everyone's information, we can sort through more quickly what's good, what we think is good, but might turn out not to be good later. And what can benefit all of us.     00;12;03;04 - 00;12;20;02  Yeah, and from a technology standpoint, gathering that data and organizing it and working with it is becoming more possible than ever. COVID should have scared our health system out of its mind. Did it? And is that leading to any systemic changes in science and health?     00;12;20;15 - 00;12;46;19  Well, I'd like to focus on what my book was focusing on, which is can a group of patient activists and scientists and clinicians and government policymakers working together make changes to the system? And I think the answer is yes. You can make changes to the system. The patient researchers that I was talking to and the families I was talking to, they built on activist patient work that had gone before.     00;12;46;19 - 00;13;10;06  And there have been responses in the past. HIV activists were able to influence the FDA to pass the accelerated approval rule that now allows drugs to be approved more quickly. And I think that, you know, compassionate use program that FDA has the patients in my family, the patients in my book and the families benefited from that as well.     00;13;10;17 - 00;13;48;01  So there have been changes along the way. But I think what my book is arguing for, and I think this message came out of the COVID 19 pandemic as well, is that even with all the changes that have been made in the past, the patient experience is still not at the heart of the system. And I think that's the message that all of these families are saying put the patient experience at the heart of things, and then you will see that the system, when you configure the system around the patient centric experience, you'll see that it will work in a different way and an I think, a better way.     00;13;48;02 - 00;13;50;02  But we need to run that experiment.     00;13;50;17 - 00;14;12;20  So we mentioned the concept of citizen scientists. That's what we've been talking about. These are people that pursue what they pursue, driven by mostly love and urgency for their kids, which is just a whole different level of motivation than most researchers have. I think you have a few stories about, you know, people like Chris and Hugh Hempel and and some others that went through this experience.     00;14;13;02 - 00;14;34;21  I want to make a point here that I think also is really important for people to understand who are listening to this. The parents in my book and you know, you cited Chris and Hugh, they were definitely among the pioneers who did this. And there was Phil and Andrea Morella, and there were also Darrel and Mark Poppea who are who are part of this, too.     00;14;34;21 - 00;14;57;29  And many, many other parents. I mean, the Parseghian Research Foundation and the National Niemann-pick Disease Foundation, all family driven. The people who are doing this. Yes, they are driven by their love of their children. They are driven by a sense of urgency. But they're not going to the FDA and saying, Hey, please pass and approve a drug because we love our children.     00;14;58;05 - 00;15;24;05  Please pass and approve a drug based on our emotion. No, not at all. They want to give effective drugs to their children. What they are saying is we are creating scientific knowledge and we think that that should be part of this approval process, that should be part of the drug development process. I just want to give some examples that I cite in the book where the parents were creators of scientific knowledge.     00;15;24;24 - 00;16;07;11  You had parents who read the scientific literature, published scientific literature, called up. The scientists interviewed the scientists came up with hypotheses themselves that they proposed to scientists, contributed to the two scientific experiments, coauthored papers that were published in the peer reviewed scientific literature. You know, went to the NIH regularly to have meetings where they helped contribute to assessing and prioritizing which compounds should go first in terms of advancing them into clinical trials, contributed their thoughts on the risk benefit analysis in devising the clinical trials.     00;16;07;22 - 00;16;34;28  One of the parents went to an FDA sponsored workshop for how to file an orphan drug designation, which is part of the approval process and the long process to getting approval for rare disease drugs. And went to the workshop, participated in the workshop, presented scientific data to the regulators, met with the regulators, and earned an orphan drug designation for one of the compound Cyclodextrin that got moved forward.     00;16;35;07 - 00;16;46;24  So yeah, they have a sense of urgency and yes, they love their children and want to save their lives, but they're producing real scientific knowledge and I really hope that that people take that message away from reading the book.     00;16;47;10 - 00;17;08;15  So those are great examples of exactly what citizen scientists do that sets them apart from just patients who are not doing that level of research, that depth of research. You talk about Chris Austin and the book, and I'm going to read another quick excerpt here, The Promise of Genetics to Deliver new interventions, new drugs and new treatments for patients is not going to happen.     00;17;08;15 - 00;17;27;28  Chris told his boss, unless there's some way to get through the valley of death. Francis gave Chris a green light to pursue his vision. So the boss in that excerpt is former National Institutes of Health director Francis Collins. What is the Valley of Death and Chris's role in citizen led research?     00;17;28;06 - 00;17;54;21  Great. No, that's a great question. So Chris Austin is a Harvard Medical School trained neurologist, also with a background in genetics who worked at pharmaceutical companies as well, and then found his way to the niche where he worked for Dr. Collins and became also a director of one of the institutes at NIH called Ed Katz, the National Center for Advancing Translational Science.     00;17;55;06 - 00;18;23;29  And one of the sort of green lights he got from Dr. Collins was to set up a lab that would have robots that were sort of at the same type of robots that pharmaceutical companies have that would work around the clock and could rapidly screen drugs to try to find compounds that might work for diseases. And what Chris Austin's idea was is that let's screen these vast libraries.     00;18;24;04 - 00;18;50;06  Let's find some drugs that might be promising, and let's also find patient partners. Let's find scientist partners, and let's then try to take all this data and move it forward together. One of the hypotheses that Chris Austin said he had as a scientist was can drug development go faster if patients and families are part of that process from the very beginning?     00;18;50;18 - 00;19;17;02  And one of the things that Chris Austin was trying to get around is this valley of death, which is this, you know, where compounds kind of go to die. You have a great idea as a scientist. But how do you get that idea from the bench to the clinic and to a patient's bedside? And the Valley of Death is just all the various obstacles that end up making it hard to develop a drug.     00;19;17;13 - 00;19;39;21  Some of it can be scientific. You know, you test it in a in a mouse or an animal, you test it in the lab and it turns out to be toxic for the cells or the amount of drug that you need to give to a person is so high it's not realistic or a drug company decides they want they don't want to put any money into it anymore or it gets or a drug company gets bought and they don't want to pursue it anymore.     00;19;39;21 - 00;20;02;08  And there's a million things that happen in the Valley of Death. But Chris Austin's vision was if we can involve patients and families as partners, along with scientists and drug developers and government officials from the beginning, maybe we can get things out of the Valley of Death, or maybe we can fail faster and find the successful compounds more quickly.     00;20;02;25 - 00;20;22;23  Yeah, a big takeaway from your book is the need to build bridges between science and citizens. But and we talked touched on this a little bit. You can't sacrifice scientific rigor or safety. So what are the challenges to building these bridges? What's holding that process back, especially when it does come to drug discovery and clinical trials?     00;20;23;09 - 00;20;47;05  So I think that there is a variety of issues that make it challenging to build bridges. For one thing, there's often a tension between, you know, people who are sick or are advocating on behalf of people who are sick, who really want to focus on the here and now. They they really need something to help their loved one right now.     00;20;47;19 - 00;21;22;19  And often, you know, clinical trials are an experiment. And when you enroll in a clinical trial, you're told this is not designed for the benefit of you. This is designed to benefit future patients. And therefore, it's not a treatment and it's not the equivalent of clinical care. And that can be a source of frustration and tension. And often also when research crews are doing research, they weigh the risk benefit assessment of moving drugs forward differently than people who are trying to you know, solve a problem now.     00;21;23;00 - 00;21;48;14  So I think that and that came up in this partnership in my book. It came up in this partnership in my book a lot. And yet I think each side was able to get a sense of what the points were, what the what the tensions were. But again, in my opinion, one of the ways that they overcame this divide was by both sides saying patient centric medicine is the way to go.     00;21;48;15 - 00;22;16;29  Patient centric science is the way to go. There are ways to collect data in a rigorous manner that can both benefit patients now and also not stop you from insights that will lead to benefits in the future. There are ways to come to terms with that. Some people have a higher acceptance of risk than others. I mean, we see movement towards that already right now.     00;22;17;01 - 00;22;23;01  I think that one of the messages of my book is to try to accelerate that even further.     00;22;23;25 - 00;22;37;19  Well, to that point, you say in the book, government and agencies like the FDA and NIH have a vested interest in helping these science and citizen partnerships succeed. Do they understand that? And what role should government be playing to move this forward?     00;22;38;01 - 00;22;57;01  Well, government is not one person. You know, so but I think that the book shows that there are people in the government who were partners with the patients and the families and the scientists and the clinicians. I mean, this whole book is about a partnership. And Chris Austin, although he's no longer in the government, he left the government.     00;22;57;10 - 00;23;28;05  He was in the government at the time, and he was a partner with these people. So I think that the government has shown in the book that, you know, and outside of my book, obviously interest in investing in new ways to do science, interest in investing in new ways to accelerate science, the government is supposed to represent the interests of the people, and the people's interest is in being healthy and in and trying to find solutions for drugs.     00;23;28;14 - 00;23;56;15  So in the book, I do talk about how the patients and the families in my book were able to directly talk to FDA regulators. Some of the parents went to workshops that the FDA was sponsoring. They had conversations with FDA regulators. I think those types of workshops are really novel and they really are fruitful because they allow the families and the patients to really think like scientists and to produce science as they can and should do.     00;23;56;16 - 00;24;21;16  They want to produce science. And I think also one of the messages that Chris Austin gave at representing the NIH was that the NIH is here to be your partner, and we're open to coming up with novel ways of accelerating science. So I think that there's there's openness to doing this, but of course, always more can be done.     00;24;21;17 - 00;24;51;16  I mean, patients have a sense of urgency, and that's the message that they bring to the government all the time. I mean, in the book, I, I describe FDA advisory committee hearings that are held when the FDA isn't sure about the data and they want to have a public hearing about it. And many of the parents and families showed up and gave testimony not just about their thoughts and their opinions, but about the data that they had gathered, the science that they were generating, that they wanted to share with the FDA and be heard.     00;24;52;00 - 00;25;16;13  What role does Rules Framework's guidelines play and what we're talking about here? I think you even your former advisor, was part of a group of scientists that worked on this framework. And the platform for patient led research, I think was spearheaded by that advisor, former advisor and a group of scientists. What's the infrastructure that needs to be put in place for this to work?     00;25;17;08 - 00;25;46;03  So, yes, So the advisor that you were referring to, Effie Diana was my advisor in my bioethics program and she does a lot of pioneering research on patient led research movements. And she and a group of collaborators, scientists and, and social scientists and clinicians and, and policymakers got together and tried to devise what they called a new social contract.     00;25;46;13 - 00;26;14;17  What they argued is, is that patient led research is a novel form of research that doesn't fit into the traditional regulatory standards that have guided, you know, clinical trials and human subjects research up until now. And that's because the traditional methods of regulation are based on the idea that scientists are going to be leading the research and doctors are going to be leading the research.     00;26;14;26 - 00;26;42;04  And that still is the traditional model. And they usually are leading the research. And in those cases, they often have more information and more power than the traditional patient or human subject. So Effie and her collaborators weren't arguing. We're arguing that the traditional rules should be thrown out because obviously patients do need protection and human subject research does need regulatory guidance.     00;26;42;11 - 00;27;17;26  But what she and the others were saying is let's also think about these new ways of doing research and how we can get scientists and clinicians to accept the results. That patient led research arrives at. And one of the ways she and the others said is let's come up with ways that patient researchers can seek ethical guidance. Let's put tools online that they can use so that they can devise experiments in ways that approach the rigor that traditional scientific experience experiments do.     00;27;18;06 - 00;27;52;04  Let's generate research that's of benefit to the people now, but also can be useful in guiding treatments in the future. Let's make a path towards publishing their data in peer reviewed journals. Let's make them part of the peer review process. I mean, you do have journals now that have patient researchers participating in peer review of scientific papers. And you have groups like Pachauri that ask scientists and patients to collaborate together on experiments.     00;27;52;13 - 00;28;24;24  So I think I think what she and the others were getting at is the current contract that we have may still be fine in certain circumstances, but isn't set up to address this new kind of research that's being done. And if we want it to be generalizable, scientific knowledge, which is always the gold standard, then we need to work together to help all of the partners to do better research that meets the standards that we can all except.     00;28;25;09 - 00;28;40;27  When you kind of make the promise of patient led research obvious. But, you know, how many times do we see things with great promise get tied up in knots? Is a paradigm shift likely? And if so, how long of a runway is that going to need?     00;28;41;15 - 00;29;01;11  I mean, I don't know how long it's going to take, but if there is a message in my book, if there is a message from the people that I focused on in my book, I mean, they've been working together for more than ten years. They've made a lot of progress, but they're not where they want to be yet.     00;29;01;20 - 00;29;23;29  So that's a long time. And I think that they want to go faster. I think the message of long COVID patients is we need to go faster. I think the message of HIV activists and breast cancer activists and disability activists is we need to go faster. And I don't think that you need to change a paradigm in a day.     00;29;24;12 - 00;29;53;19  Paradigms, by definition, take time to change, and they involve a lot of debate and discussion, dissension. And that's what happens in a society. People have different, different views. But I think what we're getting at here as a society is that patients need to be at the center of any paradigm that exists and that if everyone works together towards that goal, they may not agree how to get to that.     00;29;53;24 - 00;30;14;21  They may have different ideas on how to ensure that the science is rigorous and works. But if they keep this notion always at the center that the purpose is, is patient centered science, then I do think that you can end up with a paradigm that works better for more people.     00;30;15;16 - 00;30;27;10  One of the chapters in your book is Cathedral of Science, and in it a professor at Harvard. Had you read the story Cathedral by Raymond Carver. Why did they have you read that? And how does that relate to what we've been talking about?     00;30;28;04 - 00;30;55;26  Yeah, I mean, I say in the book that when we were told to read Cathedral by Raymond Carver, I was really surprised because usually in in my bioethics classes when we talk about stories and narrative bioethics, many of them involve sort of cases drawn from real life and cathedrals, really a quiet story that involves a married couple that seems to be drifting apart.     00;30;56;06 - 00;31;16;24  And the wife invites a friend who happens to be a blind man to come and stay with her and her husband. And the husband's a little bit jealous of the relationship that this person has with his wife and he doesn't really know what to say to him. And the wife goes to sleep and leaves these two men alone watching TV together.     00;31;17;00 - 00;31;38;19  And they start to watch a program about the building of a cathedral. And the narrator says to the blind man, Have you ever seen a cathedral? Do you know how to build a cathedral? And the blind man says, Let's draw one together. And the two of them construct a cathedral together. The man places his hand on the husband's hand, and they draw that cathedral.     00;31;38;27 - 00;32;01;23  And at the end of creating this cathedral, it's the blind man who says, Let's put some people inside, inside the cathedral. What's a cathedral without people? And I thought about this story all the time as I was spending time with the families and the scientists, because so many of the scientists were products of the Cathy trial of science.     00;32;01;23 - 00;32;34;13  They were the products of the best medical schools. They worked at the NIH. They I mean, they they really were, you know, part of this edifice that's been constructed and that has benefited so many people. And one of the things I kept thinking about is how do we put more people in this cathedral? I mean, that's really one of the messages that came through in this partnership that the parents and families and scientists and doctors and government officials were constructing a cathedral without people isn't really what you're looking for.     00;32;34;20 - 00;32;52;05  You're you're looking to use the power of science and research to help people. That's should be the goal of everything. And that's really the message I took from this story, that it touched me in just such a fundamental way. And it wasn't even a story about science.     00;32;53;27 - 00;32;57;18  As literature often does. That inspires us in many different ways.     00;32;57;21 - 00;32;58;20  Absolutely.     00;32;58;27 - 00;33;20;02  What did I miss? I mean, what is it that our listeners should know that you cover in the book that's important for them to know or some way that they can help or participate in this kind of effort? Or is there something that a follow up book might cover, something that you think needs additional exploration?     00;33;20;11 - 00;33;53;25  Well, I mean, I think that the message of the book is that we can all be scientists, right? I mean, it's in the title. We, the scientists, and I chose a title that echoes We the People, because I wanted people to think about the fact that what works best is a partnership. What works best is when we all come together and try to bring our different visions forward and to come up with something that will benefit all of us.     00;33;54;07 - 00;34;15;25  I think, you know, one of the things that I was struck by during during the research, not only for this book, but also when I, you know, covering health and science as a reporter is that all of us really are patients. We're either patients now or we were in the past or we will be in the future, or we love people who are patients.     00;34;16;04 - 00;34;50;28  We're advocates for those people, even if we're a doctor or a scientist, we're often on the other side of the table either trying to advocate for people we love or because we're patients. And so I think we all have a vested interest in creating a system that works well for all of us that remembers that we need treatments and that we that we need science and that all of us are experts in our own lives and that we can do research in a way that can contribute to advancing health and wellness for us all.     00;34;50;29 - 00;34;56;00  So I feel like that's the message that I hope is the takeaway of the book.     00;34;56;12 - 00;35;03;10  Well, I'm pretty sure there are listeners who are interested in the book and getting it or getting in touch with you. How can they do that?     00;35;04;00 - 00;35;26;00  So there are a variety of ways to get in touch with me. My email is publicly available. It's Amy Marcus at WSJ dot com. I'm on Twitter at Amy D Marcus. You can go into the bookstore and get the book, you know, in person, or you can order it online. You can get it from bookshop. You can get it from Powells.     00;35;26;00 - 00;35;32;18  You can get it from Amazon, Barnes and Noble. I mean, they're, you know, any, any, any place online. You can order the book.     00;35;32;26 - 00;36;03;05  Great. We appreciate that. And we want to thank you for being faithful listeners to Oracle Life Sciences, Research and Action. As always, we invite you to subscribe so you don't miss a single episode. And also maybe tell your friends and colleagues about the show as well. And we'll be back next time with more research and action.

In this week's episode the Powells discuss the recent sexual abuse allegations lawsuit filed against #SeanCombs by his former producer #RodneyJones AKA #LilRod . It doesn't look good as these allegations closely mirror allegations filed previously by #PDiddy ex #Cassie. Its truly #MoMoneyMoProblems. #RKelly may soon have company. #BadBoyEntertainment honcho #Puffy could end up in the pokey. #HaitiPrisonBreak has become another disaster for the troubled island of #Haiti that was once the crown jewel of the #Caribbean . This human tragedy is on par with #Gaza who is suffering a humanitarian crisis. #GazaStarving #GazaUnderAttack #GazaCeaseFireNow . #KaitlinClark is now the all time #NCAA college basketball points leader. Or is she? #AllenIversonKobeLetter is a tear jerker. #TikTok. #IsraelWar #israel #Palestine

In this week's episode the Powells discuss the recent sexual abuse allegations lawsuit filed against #SeanCombs by his former producer #RodneyJones AKA #LilRod . It doesn't look good as these allegations closely mirror allegations filed previously by #PDiddy ex #Cassie. Its truly #MoMoneyMoProblems. #RKelly may soon have company. #BadBoyEntertainment honcho #Puffy could end up in the pokey. #HaitiPrisonBreak has become another disaster for the troubled island of #Haiti that was once the crown jewel of the #Caribbean . This human tragedy is on par with #Gaza who is suffering a humanitarian crisis. #GazaStarving #GazaUnderAttack #GazaCeaseFireNow . #KaitlinClark is now the all time #NCAA college basketball points leader. Or is she? #AllenIversonKobeLetter is a tear jerker. #TikTok. #IsraelWar #israel #Palestine

Special guests James and Brittany Powell join the guys to talk about relationships, marriage, parenting, and James' latest sermon "We Need to Talk"

In this week's episode the Powells discuss the unfortunate passing of #Dr.MartinLutherKing Jr's son #DexterKing who succumbed to #prostatecancer. The fellas strongly advise Black men, all men, to get checked out. While you're at it, sign up for a #colonoscopy too. #RonDeSantis has quit his campaign leaving only #Cheetolini , and #NimrataRandhawa AKA #NikkiHaley left to lie to the American people. Are you ready for some football?? DP may give up his boycott of the #NFL to watch #LamarJackson vs #PatMahomes as the #Ravens take on the #chiefs in the #AFCChampionship. All of the guys are rooting for the #Lions.   #DetroitLions #Motown #49ERS #NFCChampionship

The topic of Gone Girl was an inevitable for this show. The 2012 bestselling phenomenon by Gillian Flynn blew millions of readers away with its stunning plot twist, but it also caused one of the biggest plot twists in Allison's own life. This episode, featuring Jayson Blair of the Silver Linings Handbook, explores the dark and faceted marriage of Nick and Amy Dunne, and they discuss the way so many of its themes resonate in real human psychology and relationships. Listen to Jayson Blair's show, The Silver Linings Handbook Podcast: https://silverliningshandbook.com/ Essay by Gillian Flynn: "I Was Not a Nice Little Girl" https://medium.com/@Powells/i-was-not-a-nice-little-girl-c2df01e0ae1

Dagens erhvervsoverblik: De store fald i markedsrenterne kan tvinge den amerikanske centralbank til at justere kursen, Fragtraterne er stigende efter missilangreb i Det Røde Hav - Det kan ramme mindre virksomheder særligt hårdt, Olieprisen stiger. Vært: Sofie Rud (soru@borsen.dk)

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we're enjoying a variety of wonderful heartfelt songs from the station library including Gospel music selections from The Nunn Sisters, Sisters, The Powells, and more. This program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes to mention a few select sources for access to radio stations all across the globe.

The Gospel Gold Radio Hour is a weekly all Gospel music program with your Host - Danny Hensley. This week we'll feature some new tunes from Stowtown Records Artists plus some very heartfelt songs from The Powells, The Nunn Sisters and more. You can hear this program four times each week on www.sbbradio.org or www.sbbradio.net and 91.7 FM Community Radio. Wednesdays at 2 AM, Fridays at 12 AM, Saturday mornings at 8 AM and and Sundays at 11 PM - all times Eastern. Join us at 91.7 FM Community Radio and streaming at live365 under Southern Branch Bluegrass and www.sbbradio.org

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we're enjoying a variety of wonderful heartfelt songs from the station library including Gospel music selections from The Nunn Sisters, Darin & Brooke Aldridge, Sisters, The Powells, Authentic Unlimited, The Kruger Brothers and more. This program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes to mention a few select sources for access to radio stations all across the globe.

In this final episode of 2023 the Powells share their thoughts on Christmas toys that they would like if they were 10 year olds today. The conversation shifts to the #JonathanMajorsVerdict and its ramifications. the guys also chop it up about the biggest surprises of #2023 . From our family to yours we wish you a #MerryChristmas a #HappyNewYear #HappyKwanza and #HolidayCheer. Until next year. Stay safe, stay healthy, and thanks for listening.

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we're enjoying a variety of wonderful heartfelt songs from the station library including Gospel music selections from these fine singers The Nunn Sisters, Darin & Brooke Aldridge, Sisters, The Powells, Authentic unlimited and more. The program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes just to mention a few select resources for immediate access for replay to radio stations all across the globe.

Fed reserve chair J Pow poured lighter fluid over a market that was already betting on a pivot in monetary policy in 2024. Bonds, share prices, commodities, have all surged after Powells announcement this Wednesday. Listen in to Mike and Jeff this week on the Feds pivot along with a cattle market update. 

The Appalachian Sunday Morning is a two hour all Gospel Music Radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net This week we're enjoying a variety of wonderful heartfelt songs from the station library including Gospel music selections from these fine singers The Nunn Sisters, Darin & Brooke Aldridge, Sisters, The Powells, 7 Mile Bluegrass and more. The program is uploaded to SoundCloud, RSS.com, radio4all, Podbean and iTunes just to mention a few select resources for immediate access for replay to radio stations all across the globe.

S&P Futures are slightly lower this morning. Markets weakness is due to Fed Chair Powell's hawkish comments, yet markets are not expecting a rate hike in December. Powells hawkish narrative was echoed by other cental bankers. Next Fed meeting is Dec 13th and according to the CEM fedWatch tool, odds are 85% that there will not be a rate hike. The U.S. arm of China's biggest bank suffered a cyber-attack. In Europe, markets are trading lower. Oil prices are higher as Saudi Arabia's Energy Minister indicates his belief that the recent sell off is due to speculators and not demand.

Tom & Ben discussed Powell's upcoming speech, Goldman Sachs looks to offload its GM credit card business, & Fund Management Takeaways.For information on how to join the Zoom calls live each morning at 8:30 EST, visit https://www.narwhalcapital.com/blog/daily-market-briefingsPlease see disclosures:https://www.narwhalcapital.com/disclosure

In this election day episode the Powelll men discuss the importance of doing your civic duty. All elections matter, and affect our lives so get out there and vote today. The guys also share their thoughts on ever evolving fashion. Hoops fans say their goodbyes to legendary Indiana University coach Bob Knight and Phoenix Suns all time leading scorer Walter Davis AKA The Greyhound. Jonathan Majors goes to trial this month. Lastly, video of R. Kelly crooning in prison shows up and the Powells give their take. #ElectionDay2023 #ElectionDay #MiamiVice #DonJohnson #PhilipMichaelThomas #SeanConnery #JamesBond #BobbyKnight #IndianaUniversity #WalterDavis #PhoenixSuns #JonathanMajors #Loki #JonathanMajorsTrial #RKelly 

Hans von Spakovski stops by the studio to discuss Former Donald Trump campaign lawyer Sidney Powell's stunning plea deal in the Georgia election subversion case on the eve of her trial.

In this week's episode the Powell men say goodbye to one of their favorite Powells. Two of us called him dad, the other two called him uncle Thurman. The conversation moves on to celebrate Prime Time Deion Sanders, or Coach Prime as his University of Colorado football team calls him. The guys share their thoughts on the arrest of Houston Rockets guard Kevin Porter Jr. NFL football is back!. Big shout out to U.S. Open women's champ Coco Gauff. #coachPrime #PrimeTime #DeionSanders #UniversityofColorado #ColoradoFootball #ColoradoBuffalos  #HoustonRockets #KevinPorterJr #KevinPorterJrArrest #NFLOpeningWeekend #Jets #AaronRogers #GiantsFootball #CocoGauff #FlashMovie 

The Gospel Gold Radio Hour is a weekly all Gospel music program with your Host - Danny Hensley. This week features music from Tim Menzies, The Powells, The Perrys, Dan Tyminiski, High Fidelity and others. You can hear this program four times each week on www.sbbradio.org or www.sbbradio.net and 91.7 FM Community Radio. Wednesdays at 2 AM, Fridays at 12 AM, Saturday mornings at 8 AM and and Sundays at 11 PM - all times Eastern. Join us at 91.7 FM Community Radio and streaming at live365 and www.sbbradio.org

Partial Transcript: After Hazel had married Congressman, Adam Clayton Powell Jr. her music career changed from late-night jazz to a more conservative, classical approach which proved to be very successful. Hazel said goodbye to 1945 and to her mother Alma but 1946 brought new life. On July 17th, Hazel gave birth to a son, Adam Clayton Powell The Third, or affectionately called, Skipper. She said, “My greatest thrill was the first time I saw Skipper.” Adam and Hazel were both very busy but they made sure they would be home on weekends. During the week, a housekeeper cared for their son. Skipper, later on, said, “They decided to try to have as normal a life as possible. (Dad) would be in Washington during the week at least January through May, and (Mom) would be traveling a lot but on Saturday and Sunday, we were going to be a family. And so wherever they were, the deal was they would have to get back to New York by Friday night.”The Powells were famous, being a celebrated and high-profile black power couple. However, behind closed doors, it was not easy, Hazel admitted, “We fought bitterly but loved each other deeply.” She confessed that she did think of ending her marriage in the first year. The constant pressure of everyday life, their bustling careers, and their public persona along with the death of her mother and a new baby were all so much for Hazel. She tried to repress her emotions which would eventually end with almost dire consequences. Along with all of her responsibilities and attention, she still dealt with constant racism. Learn and listen more:https://shows.acast.com/who-was-she-podcastAlso available on:https://podcasts.apple.com/us/podcast/who-was-she/id1548368026https://www.amazon.com/dp/B08JJS5J2T/ref=cm_sw_em_r_mt_dp_H6paGbTR63EK9https://open.spotify.com/show/78a4pv6tYgad4C0mEftAgBYou can also find more information on our social media:http://instagram.com/whowasshepodcasthttps://www.facebook.com/whowasshepodcasthttps://www.pinterest.com/whowasshepodcast Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

The Appalachian Sunday Morning is a two hour all Gospel music radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net Some of the artists featured on this week's program are The Powells, Tim Menzies, The Gaither Vocal Band and more. The program is uploaded to SoundCloud, Buzzsprout, radio4all, Podbean and iTunes just to mention a few select resources for immediate access for replay to radio stations all across the globe.

The Appalachian Sunday Morning is a two hour all Gospel music radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net Some of the artists featured on this week's program are The Powells, Deano Graham, Val Story, Clint Brown w/Sonya Isaacs and more. The program is uploaded to SoundCloud, Buzzsprout, radio4all, Podbean and iTunes just to mention a few select resources for immediate access for replay to radio stations all across the globe.

The Appalachian Sunday Morning is a two hour all Gospel music radio program with radio station & program host Danny Hensley. The program is recorded live each Sunday morning while being broadcast on 91.7 FM Community radio and streamed world wide on www.sbbradio.org and/or www.sbbradio.net Some of the artists featured on this week's program are The Powells, Deano Graham, John Berry, Clint Brown w/Sonya Isaacs and more. The program is uploaded to SoundCloud, Buzzsprout, radio4all, Podbean and iTunes just to mention a few select resources for immediate access for replay to radio stations all across the globe.

In this week's episode the Powell men discuss Tik Tok thread "Unserious Generational Curses" and share if the wisdom of the ages has been passed down to the younger Powells. Derek is missing in action this week. He's vacationing in an undisclosed location. The conversation turns to the prison stabbing of former U.S. Women's Gymnastics team doctor , and pedophile Lawrence Nasser. The guys end the pod talking summer hoops . #TikTok #UnseriousGenerationalCurses ##LawrenceNasser #DamianLillard #Wembanyama #NBASummerLeague 

In this week's episode the Powell Men open the chat with a discussion of the Web telescope (Yes we are scientifically curious). The convo continues with our thoughts on the new movie Air which chronicles the creation of the Air Jordan. The Powells reflect on the Air Jordan effect on sneakers, and sneaker culture. No one knows who Chuck Taylor was but we all know Michael Jordan. The conversation continues with a discussion of Uncle Ruckus, SCOTUS Justice Clarence Thomas and new revelations about his corruption. #WebbTelescope #NASA #WebbPhotos #Air #MattDamon #BenAffleck #ChrisTucker #JasonBateman #PhilKnight #Nike #AirJordan #Jordan1 #Converse #Adidas #ViolaDavis #SonnyVaccaro #RobStrasser #ChuckTaylor #SCOTUS #ClarenceThomasCorruption #GinniThomas

Ivy Ross is the Vice President of Design for hardware product area at Google, where she leads a team that has won over 225 design awards. She is a National Endowment for Arts grant recipient and was ninth on Fast Company's list of the one hundred Most Creative People in Business in 2019. Ross believes that the intersection of arts and sciences is where the most engaging and creative ideas are found.Susan Magsamen is the founder and director of the International Arts + Mind Lab, Center for Applied Neuroaesthetics at Johns Hopkins University School of Medicine, where she is a faculty member. She is also the co-director of the NeuroArts Blueprint. Susan works with both the public and private sectors using arts and culture evidence-based approaches in areas including health, child development, education, workforce innovation, rehabilitation, and social equity.Your Brain on Art BOOK - AMAZON, POWELLS ___________________________________Join our COMMUNITY - sign up at EastForest.orgPlease support the show by joining our East Forest COUNCIL on Patreon.  Monthly Council, live-streams, demos, and more. JOURNEY SPACE - founded by East Forest.  Online Journey Facilitation and Support. JourneySpace.com.EAST FOREST MUSIC: Spotify / AppleGuided Meditations on Spotify & AppleShop: http://eastforest.org★★★★★ Please rate Ten Laws with East Forest in iTunes & SpotifyConnect with the Forest -Mothership: http://eastforest.orgIG:  https://www.instagram.com/eastforest/Facebook: http://facebook.com/eastforestmusic

On today's show, we discuss reaction to Powells testimony, richsession in chart form, Silvergate drama, Michaels humble brags, Karen-Batnick, and much more!    Find complete shownotes on our blogs...  Ben Carlson's A Wealth of Common Sense  Michael Batnick's The Irrelevant Investor  Like us on Facebook  And feel free to shoot us an email at animalspiritspod@gmail.com with any feedback, questions, recommendations, or ideas for future topics of conversation.      (Wealthcast Media, an affiliate of Ritholtz Wealth Management, received compensation from the sponsor of this advertisement. Inclusion of such advertisements does not constitute or imply endorsement, sponsorship or recommendation thereof, or any affiliation therewith, by the Content Creator or by Ritholtz Wealth Management or any of its employees. Investments in securities involve the risk of loss. Any mention of a particular security and related performance data is not a recommendation to buy or sell that security. The information provided on this website (including any information that may be accessed through this website) is not directed at any investor or category of investors and is provided solely as general information.)