Podcasts about Gho

Lex chats with Stani Kulechov - founder and CEO of Aave, a leading decentralized finance (DeFi) protocol. They explore the evolution of DeFi, Aave's growth, and its architectural shift from a peer-to-peer model to pooled liquidity. Stani reflects on the early days of DeFi, the impact of the FTX collapse, and the increasing adoption of DeFi over centralized exchanges. They discuss Aave's strategies for attracting assets, the importance of capital efficiency, and future innovations, including the tokenization of real-world assets and the role of stablecoins. Notable discussion points: 1. Aave Reaches $40 Billion in Net Deposits: Stani Kulechov shared that Aave has achieved a record-breaking $40 billion in net deposits and $25 billion in active liquidity, making it the largest DeFi lending protocol ever by total value locked (TVL). 2. DeFi's Evolution from Peer-to-Peer to Liquidity Hubs: The conversation detailed Aave's architectural shift from early peer-to-peer lending models to pooled liquidity and now to a hub-and-spoke model with Aave V4 — designed to balance capital efficiency and risk segregation for both native crypto and real-world assets (RWAs). 3. The Rise of Real-World Assets and Stablecoins in DeFi: Kulechov emphasized that tokenized real-world assets (like treasuries) and decentralized stablecoins (such as Aave's GHO) are reshaping the DeFi landscape, predicting RWAs will outgrow both stablecoins and native crypto assets in total value locked within five years. MENTIONED IN THE CONVERSATION Topics: Aave, Lens Protocol, GHO, Horizon, FTX, Project Guardian, AaveDAO, MakerDAO, Web3, DeFi, Lending, stablecoins, tokens, RWA, decentralized finance, capital markets, DAO, Digital Assets ABOUT THE FINTECH BLUEPRINT 

The Sepolia testnet encounters a bug from the Pectra fork. The ACI proposes the Aave Savings Rate for GHO. And Devconnect 2025 will be held in Argentina. Read more: https://ethdaily.io/660

Arbitrum BoLD goes live on mainnet. Lens Chain adopts GHO as its gas token. Paradigm releases Reth v1.2. And CBOE seeks SEC approval for an Ethereum Staking ETF. Read more: https://ethdaily.io/646

Aave launches native GHO on Base. Viem releases v2.23. Holonym acquires Gitcoin Passport. And Ethereum developers propose to increase the gas utilization target. Read more: https://ethdaily.io/644

Liveset by dj Vinyl Vinnie for Rokagroove Radio on the 23rd of December 2024 Video available: https://youtu.be/Waxpra1qA0Y Facebook: https://www.facebook.com/vinylvinnie Podcast: https://podcasts.apple.com/nl/podcast/vinyl-vinnie/id1520107151 Tracklist: 01 Sunscream - Love You More 02 Bizarre Inc. feat Angie Brown - Took My Love 03 Gat Decor - Passion 04 Dj Steve & Bobi Cacen - Moon 10 (Outer Orbit) 05 The Future Sound Of London - Papua New Guinea 06 Nexus 21 - Logical Progression 07 Orr-Some - We Can Make It 08 Forgemasters - Skies Over Sheffield 09 Ursula 1000 - Movin' 2 The Sound 10. Ghoßt Assembly - I Miss Your Love 11 Moy - Ratufa 11 Zodiac Childs - Basic Process 12 Zodiac Childs - Overstep 13 Dj Absolutely Shit - Lost In. Space 14 Lew E - Touched 15 Underkut - Both Ends 16 Unknown Artist - Untitled 17 Faithless - Insomniac 18 Unknown Artist - Untitled (Luis Patti Remix) 19 Luis Patti - My Dreams 20 Piranha - I Feel 21 Lennie De Ice - We Are I.E.

Ofisi ya Umoja wa Mataifa ya Kuratibu Masuala ya Kibinadamu (OCHA) ikizindua Ripoti ya Kimataifa ya mahitaji ya Kibinadamu (GHO) kwa mwaka ujao wa 2025 imetangaza ombi la ufadhili kwani takriban watu milioni 305 duniani kote watahitaji msaada wa kibinadamu katika mwaka ujao. Selina Jerobon na maelezo zaidi.

Hii leo jaridani tunaangazia uzinduzi wa ombi la ufadhili wa mahitaji ya Kibinadamu (GHO), na umuhimu wa lugha mama katika kukuza haki za binadamu. Makala tunasalia hapa makao makuu ya umoja wa mataifa na mashinani tunakupeleka nchini Senegal, kulikoni?Ofisi ya Umoja wa Mataifa ya Kuratibu Masuala ya Kibinadamu (OCHA) ikizindua Ripoti ya Kimataifa ya mahitaji ya Kibinadamu (GHO) kwa mwaka ujao wa 2025 imetangaza ombi la ufadhili kwani takriban watu milioni 305 duniani kote watahitaji msaada wa kibinadamu katika mwaka ujao.Haki si haki iwapo inatolewa kwa lugha ambayo haileweki kwa wahusika, wamejulishwa washiriki wa mkutano wa pili wa wanazuoni unaofanyika hapa makao makuu ya Umoja wa Mataifa New York, Marekani na pia mtandaoni ukimulika Madaraka, Haki na Binadamu: Utawala wa Sheria na mabadiliko Afrika.Makala tunasalia hapa makao makuu ya Umoja wa Mataifa ambapo mkutano wa mwaka 2024 wa Taaluma kuhusu Afrika leo katika leo umeingia siku ya pili hapa Makao Makuu ya Umoja wa Mataifa jijini New York, Marekani. Mkutano huo ulioandaliwa na Ofisi ya mshauri maalum wa Umoja wa Mataifa kuhusu Afrika UNOSAA ni wa siku tatu na umebeba maudhui "Nguvu, Haki, na watu” kwa ajili ya mabadiliko ya Afrika.Na mashinani fursa ni yake Antar sarr, Kijana mkulima wa mbogamboga kutoka Senegal ambaye ni mmoja wa wanufaika wa mradi wa Mfuko wa Umoja wa Mataifa wa Maendeleo ya kilimo, IFAD unaowawezesha vijana nchini humo kwa kilimo na biashara ndogondogo ili kuondokana na fikra za kwenda Ulaya kusaka Maisha bora na ajira, akisema mradi huo imempatia matumaini.Mwenyeji wako ni Assumpta Massoi, karibu!  

Arbitrum Orbit supports LayerZero's OFT standard. Scroll releases details for its initial airdrop. Stripe acquires the Bridge stablecoin platform. And Chainlink CCIP supports GHO as a fee token. Read more: https://ethdaily.io/577

Ben Adams proposes to reduce Ethereum's slot time. Aztec Network releases its roadmap to mainnet. Aave proposes to launch native GHO on Base. And UniswapX goes live on mobile. Read more: https://ethdaily.io/568

Liveset by dj Vinyl Vinnie for Rokagroove Radio on the 4th of October 2024 Video available: https://youtu.be/aLlXpq-njqQ Facebook: https://www.facebook.com/vinylvinnie Podcast: https://podcasts.apple.com/nl/podcast/vinyl-vinnie/id1520107151 Tracklist: 01 Dj Steve & Bobi Cacen - Moon 4 (Inner Orbit) 02 Sasha & Super Flu - Astra (Saha's Daydream Mix) 03 Ursula 1000 - Movin' 2 The Sound 04 EBTG - Missing (Trance Wax Remix) 05 Ghoßt Assembly – I Miss Your Love 06 Corporation Of One - So Where Are You (Hashish Dub Mix) 07 Mike Ash - Robotik 08 M.A.S.C. - Grandstand 09 René Et Gaston - Vallée De Larmes 10 M.A.N.I.C. - I'm Coming Hardcore (UFO Project Remix) 11 ID - ID 12 Mutantbreakz - Frequency

For Episode 25 of Crypto Market Wizards, I am joined by Stani Kulechov, founder of Avara. He discusses how his childhood shaped his interest in crypto and why he decided to build ETHLend (now AAVE) in 2017. He discusses the truth about building in crypto and what he learned from having to have surgery earlier this year. Guest's Twitter: https://x.com/StaniKulechov Stani's post on health: https://hey.xyz/posts/0x05-0x2694-DA-1cd727a6 Crypto Market Wizards: https://www.youtube.com/playlist?list=PL6bwqqJO_txgGQySGK5-HSuTPp0LjeGqA Steady Lads: https://www.youtube.com/@0xSteadyLads Taiki is the founder of Humble Farmer Army, a community-driven research company founded in 2021 with a mission to create high-quality, digestible content that helps separate signal from noise for DeFi enthusiasts. Timestamps: 0:00 Stani's Childhood 3:49 Foray into Entrepreneurship 11:08 Discovering Ethereum & Building AAVE 15:16 Raising $16M in an ICO 18:24 Surviving the 2018-19 Bear Market 21:16 Memories of DeFi Summer 24:54 Neglecting Health & Requiring Surgery 30:33 Working with your Wife in Crypto 35:53 Avara's Endgame (AAVE, Lens, Family, GHO) 41:16 Advice to Younger Self 45:19 Does Vitalik Hate DeFi?

Alejandro Gutierrez, CEO of npayme Labs, joins me as we recap our recent panel at Dogpatch Labs on 'Finding Web3 Talent' and working in web3, touching on market sentiment, the cyclical nature of crypto investments, and strategies for early-stage and later-stage startups. Beyond working in web3, we delve into real-world asset tokenization, highlighting key initiatives by firms like Provenance, PayPal, Circle and Centrifuge. The conversation also covers the evolving landscape for content creators in web3, emphasizing the use of tokenization for new revenue streams and the role of AI in content creation. STORIES WE COVERED: Recap of 'Finding Talent in Web3' last week at Dogpatch Labs (Owen Healy on LinkedIn, 15-Sep-24) Friday Fund Tokenization Update (Eoin Motherway on Linkedin, 13-Sep-24) Provenance Blockchain Labs launches Fund Issuance platform, to tokenize, list, & lend RWA funds on Figure Markets (Marketwatch, 20-Aug-24) PayPal's stablecoin hits $1B market cap (Cointelegraph, 26-Aug-24) MakerDAO, rebranded as SKY to roll out new stablecoin USDS (The Block, 27-Aug-24) Circle's USDC in Brazil and Mexico Now Available to Businesses Via Banking System (CoinDesk, 17-Sep-24) Stablecoins: The Emerging Market Story (Nic Carter @ Castle Island Ventures, 12-Sep-24) Centrifuge launches a RWA lending market leveraging tokenized U.S. Treasury bills (CoinDesk, 27-Aug-24) AAVE (Avara) onboards BUIDL Shares as Collateral for GHO stablecoin (The Defiant, 29-Aug-24) Natixis launch €100M Digital Bond, secured by mortgage loan pools & operated by SC Ventures, DekaBank Deutsche Girozentrale & LBBW (Ledger Insights, 28-Aug-24) Siemens issues €300M digital bond, as the largest bond issued under Germany's eWpG. (Ledger Insights, 4-Sep-24) Creators' content is a real-world asset (Alejandro Gutierrez on X, 17-Sep-24) TIMESTAMPS: 01:40 Insights from the Web3 Talent Panel and Working in Web3 04:11 Market Sentiment and Investment Strategies 07:02 The Role of Tokenization in Web3 14:31 Real-World Asset Tokenization 28:24 Content Creation in the Web3 Era 34:01 Closing Thoughts and Farewell LINKS: Follow our guest co-host Alejandro Gutierrez: X(Twitter): https://twitter.com/A_gutierro LinkedIn: https://www.linkedin.com/in/alejandro-gutierrez-98979b43/ Learn more about:-npayme Labs: https://npayme.com/ ETH Dublin: https://ethdublin.io/ Techstars Web3 Accelerator: https://www.techstars.com/accelerators/web3 Leave a review and subscribe on Apple Podcasts: https://podcasts.apple.com/us/podcast/id1455819294 Spotify: https://open.spotify.com/show/4F8uOLxiscYVWVGEfNxTnd MoneyNeverSleeps website: https://www.moneyneversleeps.ie/ Email us: info@norioventures.com Follow on X(Twitter): Pete Townsend: https://twitter.com/petetownsendnv MoneyNeverSleeps: https://twitter.com/MNSshow Follow on LinkedIn: Pete Townsend: https://www.linkedin.com/in/pete-townsend-1b18301a/ MoneyNeverSleeps: https://www.linkedin.com/company/28661903/admin/feed/posts/ MoneyNeverSleeps newsletter on Substack: https://moneyneversleeps.substack.com/ More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page here: https://anchor.fm/irish-tech-news If you'd like to be featured in an upcoming Podcast email us at Simon@IrishTechNews.ie now to discuss. Irish Tech News have a range of services available to help promote your business. Why not drop us a line at Info@IrishTechNews.ie now to find out more about how we can help you reach our audience. You can also find and follow us on Twitter, LinkedIn, Facebook, Instagram, TikTok and Snapchat.

Alejandro Gutierrez, CEO of npayme Labs and co-founder of ETH Dublin joins me again as guest co-host this week. In this episode, we recap our recent panel on ‘Finding Web3 Talent' at Dogpatch Labs, touching on market sentiment, the cyclical nature of crypto investments, and strategies for early-stage startups. We delve into the concept of real-world asset tokenization, highlighting key initiatives by firms like Provenance, PayPal, Circle and Centrifuge. The conversation also covers the evolving landscape for content creators in Web3, emphasizing the use of tokenization for new revenue streams and the role of AI in content creation. STORIES WE COVERED: Recap of ‘Finding Talent in Web3' last week at Dogpatch Labs (Owen Healy on LinkedIn, 15-Sep-24) Friday Fund Tokenization Update (Eoin Motherway on Linkedin, 13-Sep-24) Provenance Blockchain Labs launches Fund Issuance platform, to tokenize, list, & lend RWA funds on Figure Markets (Marketwatch, 20-Aug-24) PayPal's stablecoin hits $1B market cap (Cointelegraph, 26-Aug-24) MakerDAO, rebranded as SKY to roll out new stablecoin USDS (The Block, 27-Aug-24) Circle's USDC in Brazil and Mexico Now Available to Businesses Via Banking System (CoinDesk, 17-Sep-24) Stablecoins: The Emerging Market Story (Nic Carter @ Castle Island Ventures, 12-Sep-24) Centrifuge launches a RWA lending market leveraging tokenized U.S. Treasury bills.(CoinDesk, 27-Aug-24)  AAVE (Avara) onboards BUIDL Shares as Collateral for GHO stablecoin (The Defiant, 29-Aug-24) Natixis launch €100M Digital Bond, secured by mortgage loan pools & operated by SC Ventures, DekaBank Deutsche Girozentrale & LBBW (Ledger Insights, 28-Aug-24). Siemens issues €300M digital bond, as the largest bond issued under Germany's eWpG. (Ledger Insights, 4-Sep-24)  Creators' content is a real-world asset (Alejandro Guterrez on X, 17-Sep-24) TIMESTAMPS 01:40 Insights from the Web3 Talent Panel 04:11 Market Sentiment and Investment Strategies 07:02 The Role of Tokenization in Web3 14:31 Real-World Asset Tokenization 28:24 Content Creation in the Web3 Era 34:01 Closing Thoughts and Farewell LINKS: Follow our guest co-host Alejandro Gutierrez: -X(Twitter):  https://twitter.com/A_gutierro -LinkedIn: https://www.linkedin.com/in/alejandro-gutierrez-98979b43/ Learn more about: -npayme Labs: https://npayme.com/ -ETH Dublin:  https://ethdublin.io/ -Techstars Web3 Accelerator:  https://www.techstars.com/accelerators/web3 Leave a review and subscribe on  -Apple Podcasts:  https://podcasts.apple.com/us/podcast/id1455819294 -Spotify: https://open.spotify.com/show/4F8uOLxiscYVWVGEfNxTnd -Youtube:  https://www.youtube.com/channel/UCvaaHrJjizUEd0-93mjCKsQ MoneyNeverSleeps newsletter on Substack: https://moneyneversleeps.substack.com/ MoneyNeverSleeps website:  https://www.moneyneversleeps.ie/ Email us: info@norioventures.com Follow on X(Twitter):  -Pete Townsend: https://twitter.com/petetownsendnv -MoneyNeverSleeps: https://twitter.com/MNSshow   Follow on LinkedIn: -Pete Townsend: https://www.linkedin.com/in/pete-townsend-1b18301a/ -MoneyNeverSleeps: https://www.linkedin.com/company/28661903/admin/feed/posts/

Ethereum Follow Protocol goes live on public testnet. Aave proposes a GHO integration with BlackRock BUILD. And CoinCenter says recent CFTC enforcement actions fail to provide clear guidance. Read more: https://ethdaily.io/547

One of the bluechip DeFi projects and backbone of Ethereum liquidity markets, Aave has recently announced their V4 upgrade proposal, which aims (among others) to unify crosschain liquidity.We were joined by Stani Kulechov, founder & CEO of Aave, to discuss the DeFi (r)evolution since ETH Lend to Aave V4, expanding to non-EVM chains and potentially even building a self-sovereign chain. Topics covered in this episode:The evolution of AaveAave V3 risk management & MakerDAO feudAave V4Unified liquidity layer & risk pricingGHO stablecoinHow the unified liquidity layer improves UXRWA & liquidation strategies in Aave V4Expanding to non-EVM networksBuilding a self-sovereign chainAave's role in the future of DeFiHow stablecoins will evolveDeFi institutional adoptionFuture roadmapEpisode links:Stani Kulechov on TwitterAave on TwitterLens Protocol on TwitterSponsors:Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.ioChorus1: Chorus1 is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.oneThis episode is hosted by Sebastien Couture & Friederike Ernst.

Suzy Whaley has had an amazing career in golf -- member of the PGA of America Hall of Fame, 41st President of the PGA of America, nationally recognized teacher, first woman to qualify for a PGA tour event (2003 GHO) since Babe Zaharias, and the list goes on. We talk with Suzy about how she got started in the game, her college golf experience, her pivot from heading to law school to playing on the LPGA Tour, her subsequent transition to teaching while continuing to play at a high level, the challenges of facing COVID as President of the PGA, her current role with Golf Nation and her thoughts on how to increase the exposure for the women's game.

ZKsync introduces Elastic Chains. Balancer releases its V3 codebase. RISC Zero introduces Blobstream Zero. And Aave deploys native GHO on Arbirtum. Read more: https://ethdaily.io/499 Sponsor: Harpie is an onchain security solution that protects your wallet from theft in real time. Harpie helps you detect and block suspicious transactions before they execute, safeguarding your assets from malicious attacks and scams. Try Harpie for free at harpie.io/ethdaily.

Synthetix V3 goes live on Arbitrum. A vote to deploy GHO cross-chain goes live. Ronin introduces its zkEVM built on Polygon CDK. And Devcon opens its raffle ticket auction. Read more: https://ethdaily.io/489 Sponsor: Harpie is an onchain security solution that protects your wallet from theft in real time. Harpie helps you detect and block suspicious transactions before they execute, safeguarding your assets from malicious attacks and scams. Try Harpie for free at harpie.io/ethdaily.

With tracks from Kuna Maze, Laroye, Dangerous Dan, Nicky Night Time, Rhonda Intl., Eli Escobar & Nomi Ruiz, Ripperton, SidiRum, Paresse, Matias Aguayo, Field Of Dreams, Captain Mustache, Kimshies, Ghoßt Assembly, Vince Watson, Weval, Thatmanmonkz, Trulz & Robin, DJ Fudge & Kiko Navarro, Octo Octa, Adam Port, Keinemusik, Theus Mago, Rhauder, Paul St. Hilaire. Contact: dj@ribeaud.ch.

604 - Recorded live on January 30, 2024 Ambience for the night: Ghoëst - In Eternal Sleep darkdungeondoom.bandcamp.com/album/in-eternal-sleep **Playlist** 1) Vemod - True North Beckons 2) Hauntologist - Deathdreamer 3) Isolert - Burn Them 4) Abigor - Extermination Angel **talk* 5) Wulvyr - Burned Black Cold Hills 6) Ceremonial Energy - Moving Tombstones 7) Fealty - Curse Upon The Oathbreakers **talk** 8) Master's Hammer - Kovový chrám Live every Tuesday at 9pm ET on NSTMRadio.com

Dr. Bill Griffin shares about the exciting opportunities for dentists to use their skills on GHO mission trips. GHO Trip Calendar: https://gho.servicereef.com/events?sort=upcoming

Public Goods Network winds down its OP Stack chain. Dencun successfully activates on the Goerli testnet. AltLayer introduces its ALT token launch. And Aave Labs proposes to take GHO cross-chain. Sponsor: Harpie is an onchain security solution that protects your wallet from theft in real time. Harpie helps you detect and block suspicious transactions before they execute, safeguarding your assets from malicious attacks and scams. Try Harpie for free at harpie.io/ethdaily.

Phase Two is on the way in a month, and so the Countdown Crew sits down to discuss some of the issues that we hope are placed under the microscope as the new content arrives. Touching on Premades, Rogue tanking, PvP design, the release date and much, much more, please enjoy this all you can eat buffet of SoD chatter.Phase Two Date, Cata, & Rune reveals w/ Chainmeta, Craig, Fredmunroe, Gho, Holybones, Jooda, Punchy, & Ubiquitous, - 1:35Ashenvale Rep Change & STV in Phase 2 - 44:30Hunter Pet Issues in PvP - 1:12:25Meta Warlock PvP - 1:39:45Berking News, Hunters Have Been Nerfed - 1:42:35Starsurge - 1:52:15More Hunter PvE/PvP Thoughts Post Nerf - 2:02:05Priest Healing Nerfs - 2:32:50Constructive Criticisms - 2:51:15Rogue Tanking w/ Ubiquitous & Rollo - 3:20:10Questing for Gold w/ Ayle - 5:00:45Premades w/ Ayle, Rollo, Saverem, Tareyak & Ubiquitous - 5:05:20Buy Josh a beer & help keep Countdown on the airwaves over at Patreon here: https://www.patreon.com/joshcorbett Or if subscriptions aren't your thing, support Josh & Countdown by shouting him a one time beer here: https://ko-fi.com/countdowntoclassicCheck out Josh on YouTube for gameplay streams and live podcast recordings here: https://www.youtube.com/@countdowntoclassicJoin the Countdown To Classic discord here: https://discord.gg/83thqw2fBwCheck out Josh's hilarious movie podcast here: https://open.spotify.com/show/469qUDnQHBkCogdjZyFUjb?si=jNgDTiEnSvKBbZuNz2xcxw

Ethereum's validator withdrawal queue spikes to 2 weeks. Lyra plans to use Celestia DA for Lyra Chain. Arbitrum One hits $10 billion in TVL And applications open for Aave's GHO virtual hackathon. Sponsor: Harpie is an onchain security solution that protects your wallet from theft in real time. Harpie helps you detect and block suspicious transactions before they execute, safeguarding your assets from malicious attacks and scams. Try Harpie for free at harpie.io/ethdaily.

For this week's episode, Jacquelyn interviewed Stani Kulechov, the founder of Avara, formerly known as Aave Companies. The company is probably best known for Aave protocol, its platform-focused stablecoin GHO and its social network protocol Lens.The web3-focused software technology company announced exclusively on our podcast their rebranding as well as a strategic acquisition of an Ethereum-based crypto wallet. The name Aave will still exist, but through Aave Protocol and Aave Labs, two organizations' under Avara's umbrella brand. We discussed the rebrand, acquisition, changes to projects under the Avara umbrella and content creator monetization on decentralized social media platforms and what it can look like.We also talked about: Lens transitioning out of beta phaseDecentralized versus mainstream social media The future of social networksWhat's next for Avara  Chain Reaction comes out every Thursday at 12:00 p.m. ET, so be sure to subscribe to us on Apple Podcasts, Spotify or your favorite pod platform to keep up with the action.

Shib developers deploy Layer 2 Shibarium on the Ethereum mainnet, aiming to enhance scalability. Over $1.7 million worth of Ethereum is trapped in the Shibarium Layer 2 network. SEI price drops by 31% as users begin claiming the airdrop. Singapore authorities bust a $735 million alleged money laundering case involving cryptocurrencies. Bitcoin and Ethereum exhibit lower volatility than oil, according to Kaiko research. Aave's stablecoin GHO trades below its intended dollar peg, raising questions about its stability. Bitcoin hits an all-time high in Argentina following Javier Milei's surprising win. Asset manager Valkyrie files an Ethereum-focused ETF with the US SEC.#CryptoNews #Shibarium #SEI #Airdrop #CryptoLaundering #Bitcoin #Ethereum #Aave #GHO #Argentina #Valkyrie #ETF _________News Links

IntoTheBlock releases a risk radar dashboard for GHO. Starkware releases a short-term roadmap for Cairo. Aztec Network kicks off retroactive grants for Noir contributions. And Curve adds leveraged borrowing for crvUSD.

3rd Week of July 2023 ------

Worldcoin migrates to OP Mainnet. Espresso Systems launches its Doppio testnet. Core developers address edge cases with EIP-6780. And Balancer launches liquidity pools for GHO.  Read more: https://ether.fm/689

19th July: Crypto & Coffee at 8

Welcome to this week's podcast, where our expert panel dives into a wide range of topics shaping the crypto landscape.This week, Special guest Jordan Salberg, Senior Counsel, Product kicks off the discussion by providing insights on the recent XRP ruling, what that means for the industry and other assets. He also updates us on the ongoing ETF process and what we should be looking out for in the coming weeks.Georg delves into fund inflows and outperformance of certain alt coins. He also covers BTC/ETH dominance trends, his thoughts on the pull back towards the end of the week and some of the recent positive comments.David focuses on recent inflation print, discussing their implications for the broader economy. He also provides insights on the upcoming Fed meeting and the latest economic data from China, offering a comprehensive macroeconomic perspective.Greg takes a closer look at market flows, analyzing the impact of the recent summary judgment on market dynamics. He also explores the options markets, providing valuable insights into trading trends and also his perspective on the pull back.Tammy Yang, a Senior Blockchain Researcher steps in for Sid, providing an update on custodial and non-custodial stablecoins. She highlights the recent launch of Gho by Aave and offers insights into the evolving landscape of stablecoin solutions.Please, don't forget to like and subscribe so others can benefit from the team's great content!HostBen Floyd, Head of Execution ServicesSpecial GuestJordan Salberg, Senior Counsel, ProductPresentersGeorg Toropov, Senior CES SalestraderDavid Duong, Head of Institutional ResearchGreg Sutton, Senior CES SalestraderTammy Yang, Senior Blockchain ResearcherLink to Research and Insights Hubhttps://www.coinbase.com/institutional/research-insights

幻冬舎の暗号資産（仮想通貨）/ブロックチェーンなどweb3領域の専門メディア「あたらしい経済 https://www.neweconomy.jp/ 」がおくる、Podcast番組です。 ○解説したニュース ・Uniswap Labs、新たなルーティングプロトコル「UniswapX」リリース ・大阪万博のデジタルウォレット、ハッシュポートが協賛 ・米SECが各社の現物ビットコインETF申請を続々と受理、ブラックロックに続きヴァルキリーも ・アンストッパブル・ドメインズ、ENSの「.eth」ドメインをサポート開始 ・Gnosisが新決済サービスとデビットカードをローンチ、Visa・Safe協力で ・バイナンス、ビットコインの入出金をライトニングネットワークに対応開始 ・コインベース、米国4州でステーキングサービス提供を一時停止 ・Aave、イーサリアム上で米ドルステーブルコイン「GHO」ローンチ ・グッチがオークションハウスChristie'sでNFTコレクションリリースへ、草野絵美も参加 ・セルシウスが米当局らから提訴、元CEOは詐欺罪など複数の罪で逮捕 ・BNBビーコンチェーン、7月下旬に「ZhangHeng」アップグレード実施予定 ・Bリーグ「大阪エヴェッサ」、FiNANCiEでトークン発行 ○番組スポンサー この番組は株式会社フィナンシェの提供で送りします。 ・株式会社フィナンシェ 「FiNANCiE（フィナンシェ）」は、スポーツチームやエンタメプロジェクト、DAOなどのトークンを購入して支援ができる新しいクラウドファンディング・サービス。サッカーJリーグ、野球、バスケ、などのプロスポーツチームをはじめ、映画やアイドル、インフルエンサーなど100以上のプロジェクトのトークンがフィナンシェで購入できます。さらにトークン購入者はプロジェクトに応じたキャンペーン参加やNFTなどの特典も。ぜひiOSやAndroidで「FiNANCiE」のスマホアプリを入れて、新たな応援体験を味わってください。「あなたの夢が、みんなの財産になる」FiNANCiE →App Store（対応OS：iOS 12.0以上）はこちら https://apps.apple.com/jp/app/financie/id1470196162 →Google Play（対応OS：Android 6.0以上）はこちら https://play.google.com/store/apps/details?id=jp.financie.ichiba ○関連リンク ニュースの詳細や、アーカイブやその他の記事はこちらから www.neweconomy.jp/

Today's Daily Crypto News: SEC's review of BlackRock's spot Bitcoin ETF application, along with BlackRock's CEO making significant predictions about transcending the US dollar with cryptocurrencies. Explore the recent staff reduction at Binance and Brazil's CBDC allowing the central bank to freeze funds and adjust balances. Gain insights into Cathie Wood's Ark selling more Coinbase shares, the rise of Aave's dollar-pegged GHO stablecoin, the surge in 1inch token's value driven by South Korean trading volumes, and the movement of 30k Bitcoin supply during market dips. Stay informed with our comprehensive coverage of these notable developments in the crypto industry.#CryptoNews #SEC #BitcoinETF #BlackRock #Binance #CBDC #CathieWood #Stablecoin #MarketUpdate #Podcast_________News Links

Celo proposes to transition its L1 chain to an L2. Aave's GHO stablecoin goes live on mainnet. zkSync airdrops an experimental NFT collection. And Unstoppable Domains adds support for ENS domains.

幻冬舎の暗号資産（仮想通貨）/ブロックチェーンなどweb3領域の専門メディア「あたらしい経済 https://www.neweconomy.jp/ 」がおくる、Podcast番組です。 ○解説したニュース ・Uniswap v3、アバランチ（AVAX）で稼働開始 ・フィンシア財団、ガバナンス初期メンバーにソフトバンクやLINE NEXTなど参画 ・アスター渡辺創太のスターテイル、日本法人のトークン発行等サポートするBOBGと資本業務提携 ・イーサリアムL2「StarkNet」、Quantum Leapアップグレード完了 ・Aave、イーサリアムでの米ドルステーブルコイン「GHO」ローンチに向けガバナンス投票を開始 ・クロスチェーンプロトコル「Axelar」がマイクロソフトと提携、ブロックチェーンの相互運用性製品の提供に向け ・欧州銀行監督機構、ステーブルコイン基準の早期導入を要請＝ロイター ・韓国、企業に暗号資産保有情報などの情報開示を義務付け、2024年から ・マインクラフトのサーバーにビットコイン獲得機能を導入、ゲーム業界向けBTC決済Zebedeeが ○番組スポンサー この番組は株式会社フィナンシェの提供で送りします。 ・株式会社フィナンシェ 「FiNANCiE（フィナンシェ）」は、スポーツチームやエンタメプロジェクト、DAOなどのトークンを購入して支援ができる新しいクラウドファンディング・サービス。サッカーJリーグ、野球、バスケ、などのプロスポーツチームをはじめ、映画やアイドル、インフルエンサーなど100以上のプロジェクトのトークンがフィナンシェで購入できます。さらにトークン購入者はプロジェクトに応じたキャンペーン参加やNFTなどの特典も。ぜひiOSやAndroidで「FiNANCiE」のスマホアプリを入れて、新たな応援体験を味わってください。「あなたの夢が、みんなの財産になる」FiNANCiE →App Store（対応OS：iOS 12.0以上）はこちら https://apps.apple.com/jp/app/financie/id1470196162 →Google Play（対応OS：Android 6.0以上）はこちら https://play.google.com/store/apps/details?id=jp.financie.ichiba ○関連リンク ニュースの詳細や、アーカイブやその他の記事はこちらから www.neweconomy.jp/

Aave publishes an AIP to deploy $GHO on mainnet. BGD Labs introduces Aave Delivery Infrastructure. 20% of all ether is now staked on the Beacon Chain. And Stader Labs goes live on mainnet. Read more: https://mirror.xyz/ethdaily.eth/D7rT2o5T7p0R9PQ6lPpF6K7Z654WHp0MU0QVRUM1nqo

Join us on "Just Another Kill Team Podcast" as we take a captivating plunge into the North Carolina scene alongside our special guest, Straum. In this episode, we recount thrilling stories of battle during the Hot Melee Summer, unravel the sinister machinations of Chaos Cults, contemplate the unlikely allies found in goats, and confront the gruesome horrors of the Gellarpox Infected. Prepare to be enthralled by a captivating blend of war stories, tactics, and unexpected twists!Just Another Kill Team Podcast Discord Link:https://discord.gg/6653HG9XKb Atomic Empire https://www.atomicempire.com/ Straum plays Kill Team https://www.youtube.com/@georgepratt Just Another Kill Team podcast Patreon Link:https://www.patreon.com/JustAnotherKillteamPodcast Travis is running GHO!https://www.eventbrite.co.uk/e/goonhammer-open-kill-team-tournament-2023-tickets-660904211287  Support the show

Muneeb Ali joins us to discuss how Stacks is bringing DeFi to Bitcoin. We cover Stacks design, the Bitcoin DeFi thesis, L2 security guarantees, Stacks' recent implementation bug and more! And as usual, we start the episode with our analyst bullpen to discuss Aave's GHO, TradFi announcements, Optimism's Bedrock, Frax governance shenanigans and BitDAO. - - Timestamps: (00:00) Introduction (00:55) Hot Seat/Cool Throne (27:19) Interview Start: Stacks (42:22) The Proof-of-Transfer Mechanism (46:55) The Nakamoto Release: A Security Budget Upgrade (53:21) The Bitcoin DeFi Thesis (57:49) Bitcoin Subnets (1:01:10) The “Stack Increase” Bug (1:17:15) Bitcoin MEV and Censorship (1:25:03) Increasing Miner Competition (1:28:37) Reorg Concerns and Orphan Blocks - - Follow Muneeb: https://twitter.com/muneeb Follow Sam: https://twitter.com/swmartin19 Follow Dan: https://twitter.com/smyyguy Follow Ren: https://twitter.com/purplepill3m Follow Pibblez: https://twitter.com/0xpibblez Follow Blockworks Research: https://twitter.com/blockworksres Subscribe on YouTube: https://bit.ly/3foDS38 Subscribe on Apple: https://apple.co/3SNhUEt Subscribe on Spotify: https://spoti.fi/3NlP1hA Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ - - Today's episode is brought to you by the Atom Accelerator, now offering grants to build out the ATOM economic zone! It's the perfect time to build with Cosmos and join the thriving ATOM ecosystem. With Interchain Security live, and the power of IBC connecting the interchain, builders are flocking to Cosmos. Join the ranks of Neutron, Lido, Astroport, Gitcoin, Mars and numerous other projects harnessing Cosmos' leading infrastructure. Discover how to secure a grant from the Atom Accelerator by visiting https://www.atomaccelerator.com/ today!  - - Resources: Stacks https://www.stacks.co/ Stacks Roadblocks (Blockworks Research Twitter thread) https://twitter.com/blockworksres/status/1659228801384194049 - - Check out Blockworks Research today! Research, data, governance, tokenomics, and models – now, all in one place Blockworks Research: https://www.blockworksresearch.com/ Free Daily Newsletter: https://blockworks.co/newsletter - - Disclaimer: Nothing said on 0xResearch is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Dan, Sam, and our guests may hold positions in the companies, funds, or projects discussed.

This episode is sponsored by PayPal.The most valuable crypto stories for Wednesday, June 7, 2023."The Hash" panel explores today's top stories moving the crypto markets: a U.S. judge ordered the SEC to respond to Coinbase's rulemaking petition within a week. Separately, in stablecoin land, Circle Singapore received its Major Payment Institution (MPI) license for digital payment token services in Singapore, while lending protocol Aave's gho (GHO) stablecoin took a step closer to an Ethereum mainnet launch. Plus, Louis Vuitton is releasing physical-backed NFTs, and pepecoin (PEPE) investors may only have a limited window for potential gains.See also:Coinbase CEO Armstrong Says Not Shutting Down Staking Service The SEC Is Fighting the Last WarSEC Sues Crypto Exchange Binance and CEO Changpeng Zhao, Alleging Multiple Securities ViolationsStablecoin Issuer Circle Receives Digital Token License in SingaporeLouis Vuitton To Release $42,000 Physical-Backed NFTs3 Reasons Why Beauty on the Blockchain Makes SenseThis episode has been edited by senior producer Michele Musso and the executive producer is Jared Schwartz. Our theme song is “Neon Beach.”From our Sponsor:PayPal provides a secure and convenient platform for converting dollars into crypto. Start exploring new web3 applications with peace of mind knowing that PayPal has your back. Buy, Sell, Hodl, Transfer, Send, and Checkout with Crypto. All with PayPal. Get started today at PayPal.com/crypto.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode is sponsored by PayPal.The most valuable crypto stories for Wednesday, June 7, 2023."The Hash" panel explores today's top stories moving the crypto markets: a U.S. judge ordered the SEC to respond to Coinbase's rulemaking petition within a week. Separately, in stablecoin land, Circle Singapore received its Major Payment Institution (MPI) license for digital payment token services in Singapore, while lending protocol Aave's gho (GHO) stablecoin took a step closer to an Ethereum mainnet launch. Plus, Louis Vuitton is releasing physical-backed NFTs, and pepecoin (PEPE) investors may only have a limited window for potential gains.See also:Coinbase CEO Armstrong Says Not Shutting Down Staking Service The SEC Is Fighting the Last WarSEC Sues Crypto Exchange Binance and CEO Changpeng Zhao, Alleging Multiple Securities ViolationsStablecoin Issuer Circle Receives Digital Token License in SingaporeLouis Vuitton To Release $42,000 Physical-Backed NFTs3 Reasons Why Beauty on the Blockchain Makes SenseThis episode has been edited by senior producer Michele Musso and the executive producer is Jared Schwartz. Our theme song is “Neon Beach.”From our Sponsor:PayPal provides a secure and convenient platform for converting dollars into crypto. Start exploring new web3 applications with peace of mind knowing that PayPal has your back. Buy, Sell, Hodl, Transfer, Send, and Checkout with Crypto. All with PayPal. Get started today at PayPal.com/crypto.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Aave Companies publishes a proposal to launch GHO on mainnet. Optimism successfully upgrades to Bedrock. Coinbases faces a lawsuit from the SEC. And Sushi introduces a DEX aggregator. Read more: https://ethdaily.io/644

Stani Kulechov joins us to discuss how Aave and Lens are building scalable primitives to accelerate crypto's adoption curve. We explore crypto's killer app, why decentralized social matters, how the Momoca DA layer scales Lens, the incentives behind building GHO and more! And as usual, we start the episode with our analyst bullpen to discuss Coinbase's new subscription product, Lido exit liquidity games and Curve's LLAMA lending protocol. - - Timestamps: (00:00) Introduction (00:43) Hot Seat/Cool Throne (34:59) Interview Start: Crypto's Adoption Curve and Killer App (46:35) Should Protocols Share Revenue With Token Holders? (51:00) Why Decentralized Social Media? (57:07) Building on Polygon (1:03:16) Lens Tx Process Flow and the Momoca DA Layer (1:14:46) Aave's GHO (1:18:38) How Spark Will Influence Aave's Market for DAI Lending (1:21:57) Building Core Infrastructure (1:24:49) Decentralized Identity Solutions & Undercollateralized Loans - - Follow Stani: https://twitter.com/StaniKulechov Follow Sam: https://twitter.com/swmartin19 Follow Dan: https://twitter.com/smyyguy Follow Purplepill: https://twitter.com/purplepill3m Follow EffortCapital: https://twitter.com/EffortCapital Follow Blockworks Research: https://twitter.com/blockworksres Subscribe on YouTube: https://bit.ly/3foDS38 Subscribe on Apple: https://apple.co/3SNhUEt Subscribe on Spotify: https://spoti.fi/3NlP1hA Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ - - Today's episode is brought to you by the Atom Accelerator, now offering grants to build out the ATOM economic zone! It's the perfect time to build with Cosmos and join the thriving ATOM ecosystem. With Interchain Security live, and the power of IBC connecting the interchain, builders are flocking to Cosmos. Join the ranks of Neutron, Lido, Astroport, Gitcoin, Mars and numerous other projects harnessing Cosmos' leading infrastructure. Discover how to secure a grant from the Atom Accelerator by visiting https://www.atomaccelerator.com/ today!  - - Resources: Check out Blockworks Research today! Research, data, governance, tokenomics, and models – now, all in one place Blockworks Research: https://www.blockworksresearch.com/ Free Daily Newsletter: https://blockworks.co/newsletter - - Disclaimer: Nothing said on 0xResearch is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Dan, Sam, and our guests may hold positions in the companies, funds, or projects discussed.

Aave's $GHO stablecoin is now live on testnet. Kraken shuts down staking services for U.S. clients. MakerDAO announces a DAI lending protocol. And Optimism conducts a surprise OP token airdrop. Newsletter: https://ethdaily.substack.com

In this week's episode, Anna (https://twitter.com/annarrose) and Josh Cincinnati (https://twitter.com/acityinohio) chat with Matt Green (https://twitter.com/matthew_d_green), a cryptographer and professor at Johns Hopkins University (https://isi.jhu.edu/). They explore Matt's background in security, blockchain and privacy technologies. He shares his thoughts on early ZK blockchain research, the founding of Zcash, growth in the ZK space, how the industry is ready for tangible use-cases and navigating anonymity and regulatory bodies. This episode closes with a review of Matt's perspective on the Tornado Cash sanctions and what this means for the space. Here are some additional links for this episode: * Radiant Commons Website (https://radiantcommons.com/) * Sealance Website (https://www.sealance.io/) * Zerocash: Decentralized Anonymous Payments from Bitcoin by Ben-Sasson, Chiesa, Garman, Green, Miers, Tromer, and Virza, 2014 (http://zerocash-project.org/paper) * An approximate introduction to how zk-SNARKs are possible by Vitalik Buterin (https://vitalik.ca/general/2021/01/26/snarks.html) * Episode 245: Sanctions against Tornado Cash: a Legal Perspective (https://zeroknowledge.fm/245-2/) Join the ZK HACK III - kick off event here (https://hopin.com/events/zk-hack3-1-d5d6ce6b-9a79-496f-9a82-be39ebd22e84) Join the ZK HACK Discord (https://discord.com/invite/tHXyEbEqVN) This week's episode is sponsored by Aave (https://aave.com/). Aave Grants (https://aavegrants.org/) is a community-led grants program, focused on growing a thriving ecosystem of contributors within Aave by funding ideas, projects and events that benefit the protocol or surrounding ecosystem. Aave's latest deployment, V3, was launched on 6 networks and introduces new features like Isolation Mode, Efficiency Mode and Portals. A decentralized, collateral-backed stablecoin native to Aave called GHO has also been announced. Look out for more details on the testnet and release coming soon. Explore the protocol at Aave.com (https://aave.com/) and if you're building in the ecosystem, apply for a grant through aavegrants.org (https://aavegrants.org/). If you like what we do: * Find all our links here! @ZeroKnowledge | Linktree (https://linktr.ee/zeroknowledge) * Subscribe to our podcast newsletter (https://zeroknowledge.substack.com) * Follow us on Twitter @zeroknowledgefm (https://twitter.com/zeroknowledgefm) * Join us on Telegram (https://zeroknowledge.fm/telegram) * Catch us on Youtube (https://zeroknowledge.fm/) * Head to the ZK Community Forum (https://community.zeroknowledge.fm/) * Support our Gitcoin Grant (https://zeroknowledge.fm/gitcoin-grant-329-zkp-2)

Aave founder Stani Kulechov joins Dan Roberts and Stacy Elliott to talk about his vision for the next iteration of DeFi, Aave V3 and Lens Protocol, the Web3 company he wishes he had founded, and why now is the right time for the $5B lending protocol to launch its GHO stablecoin. Hosted on Acast. See acast.com/privacy for more information.

Introduction: False positive RPR. By Hector Arreaza, MD. Read by Alinor Mezinord, MS III, Ross University School of Medicine.  Today we will talk about syphilis. Significant research has been done to determine the origin of this ancient infection. Some experts support that syphilis originated in the New World (the Americas) because the first cases in Europe were reported after the Christopher Columbus crew returned from their expeditions. On the other hand, some people defend the idea of the origin of syphilis in the Old World. Whatever its origin, syphilis is still affecting thousands of people worldwide. According to the World Health Organization, “syphilis in pregnancy is the second leading cause of stillbirth globally and also results in prematurity, low birth weight, neonatal death, and infections in newborns.”[1] The cases in the US are not as high as in other countries, but certain areas have cases higher than the national or state average. Such is the case in Kern County. Our incidence of syphilis is higher than the national average.That's why it is important to screen for this disease. RPR is the most common test to screen for syphilis; however, it may not be completely accurate. RPR is a non-treponemal test that can cause false positive results. On December 20, 2021, the CDC released a letter announcing an FDA alert regarding a high RPR false positive rate when done with Bio-Rad Laboratories BioPlex 2200 Syphilis Total & RPR kit. You may not know which kit was used for the test, but you need to know what to do with a positive RPR. Some conditions associated with false positive RPR include COVID-19 vaccines, tuberculosis, endocarditis, rickettsial disease, recent immunizations (smallpox), and pregnancy. In case of RPR positive, you need to confirm syphilis with a treponemal test, which will be more reliable regardless of the possibility of a false positive RPR. We still need to screen because syphilis continues to increase in our nation. I hope you enjoy this episode.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.___________________________Latent Syphilis. By Carol Avila, MD. Comments by Hector Arreaza, MD. Dr. Avila: I had the amazing opportunity to do inpatient pediatrics during my first rotation at a local hospital, and I often treated patients with neonatal syphilis. I was curious to know what is happening in this area (Bakersfield) that made syphilis (seems to me) a very frequent diagnosis of admission in peds, especially because newborns are impacted by a preventable disease.Epidemiology:The latest update available on the CDC website is the 2020 Surveillance Report of Nationally Notifiable STDs which showed:-In 2020, the national rate of syphilis was about 40 per 100,000 population (all stages).-The rate of national congenital syphilis was about 57 cases per 100,000 live births.-During that year, California was ranked #7 for primary and secondary syphilis (P&S), with a 19.5 per 100,000 population. Nevada was the number #1 state.Local data:In 2018 data, the Kern County Public Health Services Department reported:-A total of 1,520 cases of syphilis (all stages) were diagnosed during that year, about 4 cases/day. It is important to mention that there was a spike in the number of cases of syphilis by 86% compared to the prior year, 2017.-In 2020, 250 cases of congenital syphilis per 100,000 live births were reported in Kern County. Significantly higher than the national average (mentioned above, 40 cases per 100,000 residents). -For primary and secondary syphilis, Kern County was 62% higher than the state average, with almost 35 per 100,000 population, and was ranked #6 in the state of California. -San Francisco was ranked #1.-Bottomline: The rate of syphilis and congenital syphilis in Kern County is higher than the state and national average.Definition:Syphilis is a systemic bacterial infection caused by the gram-negative spirochete Treponema pallidum. Transmission:Syphilis is well known as a sexually transmitted disease; however, while many cases happen due to sexual activity, there are a few other ways that syphilis can also be spread.-It can be transmitted during pregnancy, resulting in congenital syphilis.-Also, passing on syphilis via blood transfusions was very common but is now rare thanks to blood supply screening.-Syphilis transmission is also possible through an organ donor, which nowadays is very rare.-Before healthcare providers were wearing gloves as a standard precaution, it was common for syphilis lesions to appear on their fingers and noses.-It can also be transmitted through close and repetitive contact with mucosal or skin lesions of people with active syphilis.Classification:-Syphilis is divided into stages based on clinical findings. Primary, secondary, and tertiary.-The latent phase occurs between secondary and tertiary. -Patients pass through secondary syphilis and may not realize it.-The most contagious stages are primary and secondary, and syphilis could still be contagious in the early latent phase.-Easy classification: Early (primary, secondary, early latent); Late (tertiary and late latent); Neurosyphilis (which occurs any time).Primary syphilis:-It usually happens 3 weeks after the initial contact with the spirochete, but it can also be seen after 90 days. The bacteria will destroy the local tissue when we see the syphilitic chancre, a painless, well-demarcated lesion with firm, indurated margins. It might go unnoticed; without treatment, the bacteria will spread to the bloodstream, and the infection will progress to the secondary stage.Secondary syphilis:-In the secondary stage, the patient can have a wide variety of signs and symptoms. General constitutional symptoms are common; however, it is characterized by a body-wide rash, prominent in palms and soles. This rash can be macular, papular, or pustular; patients can also develop patches in oral mucosa and tongue, as well as wart-like sores called condylomata lata. Tertiary syphilis:-In the pre-antibiotic era, 15 to 30 years after the initial infection, patients could develop any of the three forms of tertiary syphilis. -Cardiovascular syphilis involves the ascending thoracic aorta. Patients may present with aorticaneurysm or left heart failure. -Gummatous syphilis is uncommon, but it is especially important in patients coinfected with HIV. Gummas can appear in the skin, bones, or internal organs. -Central Nervous System syphilis presents with general paresis, tabes dorsalis, meningitis, hearing and vision loss, and dementia.Latent syphilis:-It occurs when the patient has positive serology for T. pallidum, but the patient is asymptomatic. -Latent syphilis can also be divided into early latent (when the primary infection occurred within the previous 12 months); and late latent syphilis (when the primary stage happened more than 12 months ago.)-Differentiating early and late latent syphilis is vital because the treatment will differ.Congenital syphilis:-The infection occurs during pregnancy.-It can cause miscarriage, stillbirth, or birth defects like nasal cartilage destruction, and frontalbossing, among others. Screening and Diagnostic Testing:-The USPSTF recommends screening asymptomatic, nonpregnant adults and adolescents at increased risk for syphilis infection (Grade A).-The USPSTF recommends early screening for syphilis infection in all pregnant women. as early as possible when they first present to care. -Repeat screening: The CDC and joint guidelines from the American Academy of Pediatrics (AAP) and the ACOG endorse repeat screening, especially for women at risk, early in the third trimester (at about 28 weeks of gestation) and again at delivery.-High-risk patients include men who have sex with men (MSM) and men and women living with HIV. -Also, people with a history of incarceration, a history of commercial sex work, certain racial/ethnic groups (African Americans and Hispanics), and being a male younger than 29 years.How to screen: -Initial screening should be done with a nontreponemal test (RPR or VDRL); if positive, a treponemal test (TP-PA or FTA-ABS) would be the next step. -Nontreponemal tests can be positive in patients with preexisting conditions, e.g., collagen vascular diseases, pregnancy, malignancy, tuberculosis, etc.-The USPSTF also refers to the reverse sequence screening algorithm, where we perform a treponemal test first in those patients that could be missed after a nontreponemal test, for example, people who are homeless, also in nontraditional and nonclinical settings. -A treponemal test will be followed by a nontreponemal test, however, there is no evidence of the accuracy of this screening algorithm, so it is an open field for researchers.-Remember that most patients will have positive antibodies for life, irrespective of treatment or disease stage.Treatment:-One word: Penicillin is the treatment of choice.-Additionally, every patient diagnosed with primary and secondary syphilis should be tested for HIV and other sexually transmitted diseases at the time of diagnosis. Primary, secondary, and early latent syphilis: Benzathine penicillin G, 2.4-million-unit IM, in a single dose.-Children/Infant age > 1 month of age: Benzathine PCN G, 50,000 units/kg body weight IM up to 2.4 million-unit in a single dose. -Children > 1 month with P&S syphilis should be evaluated for sexual abuse.Arreaza:-Pregnancy: Treatment is still penicillin G, if there is a penicillin allergy, desensitization should be done in a controlled setting.-In non-pregnant with PCN allergy- alternatives are doxycycline 100 mg BID x14 days or Ceftriaxone 1 G daily IM or IV for 10-14 days.-For P&S syphilis: clinical and serological evaluation should be done at 6 to 12 months after treatment. Late latent syphilis and tertiary: Benzathine penicillin G, 7.2-million-unit total, administered as 2.4 million units IM each week x3 doses. (2.4 x3 = 7.2). A good strategy is to assume all latent syphilis are late latent. -Follow up with a quantitative nontreponemal serologic test at 6, 12, and 24 months, and compare thistiter with the initial titer at the time of diagnosis.-Special recommendation: Check RPR titer the same day you give the first dose of penicillin.Neurosyphilis: -CSF examination is recommended if neurologic findings are present.-If neurosyphilis is confirmed, it will require aqueous penicillin G, 3-4 million units IV every 4 hours for 10-14 days. Alternative ceftriaxone 2 G IV daily x14 days. Get guidance from an ID specialist. We will continue talking about syphilis in another episode, which was an excellent introduction.____________________________Conclusion: Now we conclude episode number 112, “Syphilis Basics.” Dr. Avila raised our awareness of syphilis in our community and the importance of screening all adolescents and adults at risk of infection, and especially ALL pregnant persons, during their first prenatal visit or as early as possible. Timely treatment with penicillin is important to prevent late complications of syphilis and especially to prevent the devastating consequences of congenital syphilis. This week we thank Hector Arreaza, Carol Avila, and Alinor Mezinord. Audio edition by Adrianne Silva.Even without trying, every night, you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you; send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!References:1. Data on syphilis, The Global Health Observatory, World Health Organization, who.int, https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/data-on-syphilis,  accessed September 14, 2022. 2. Center for Disease Control and Prevention. (2022, April 11). National Overview of STD.  https://www.cdc.gov/std/statistics/2020/overview.htm#CongenitalSyphilis. 3. STDs in Kern County, Kern County Public Health Services Department, STDS in Kern County 2018, https://kernpublichealth.com/wp-content/uploads/STDs-in-Kern-County-2018-slide-set-comparison.pdf, downloaded on Sep 12, 2022. 4. Center for Disease Control and Prevention. (2022, April 4). Reported Cases and Rates of Reported Cases by State, Ranked by Rates, United States, 2020. https://www.cdc.gov/std/statistics/2020/tables/13.htm 5. Morgen, Sam, Reported cases of STDs in Kern County dropped in 2020, but decrease could be misleading, The Bakersfield Californian, Apr 17, 2022, bakersfield.com, https://www.bakersfield.com/news/reported-cases-of-stds-in-kern-county-dropped-in-2020-but-decrease-could-be-misleading/article_6e7d8d36-bd18-11ec-a98f-7f247bc2517e.html. 6. U.S. Preventive Services Task Force. (2016, June 7). Syphilis Infection in Nonpregnant Adults and Adolescents: Screening. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/syphilis-infection-in-nonpregnant-adults-and-adolescents. 7. Center For Disease Control And Prevention. (2022, July 21). Sexually Transmitted Infections Treatment Guidelines. https://www.cdc.gov/std/treatment-guidelines/syphilis.htm. 8. Calonge N; U.S. Preventive Services Task Force. Screening for syphilis infection: recommendation statement. Ann Fam Med. 2004 Jul-Aug;2(4):362-5. doi: 10.1370/afm.215. Erratum in: Ann Fam Med. 2004 Sep-Oct;2(5):517. PMID: 15335137; PMCID: PMC1466700. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1466700/. 9. Royalty-free music used for this episode: Good Vibes Alt Mix by Videvo, downloaded on May 06, 2022 from https://www.videvo.net/royalty-free-music-track/good-vibes-alt-mix/1017292/ 

On this episode of “Out of Office: A Travel Podcast,” Kiernan recounts his travels in the secluded mountain kingdom of Bhutan, which just last week reopened its borders to tourists after 2.5 years of COVID restrictions. Extraordinary scenery, Gross National Happiness, and penis deities abound! Things We Talked About: https://en.wikipedia.org/wiki/Bhutan https://en.wikipedia.org/wiki/Gho https://en.wikipedia.org/wiki/Kira_(Bhutan) https://en.wikipedia.org/wiki/Gross_National_Happiness https://www.nytimes.com/2013/06/29/opinion/bhutan-is-no-shangri-la.html https://en.wikipedia.org/wiki/Paro_Taktsang https://en.wikipedia.org/wiki/Drukpa_Kunley https://themalamarket.com/ http://time.com/5534495/hot-abraham-lincoln-statue/

Dr. Trish Burgess talks about her new book God Sightings, a collection of stories of the best God sightings from GHO mission trips around the world with Dr. Mike Chupp on this week's CMDA Matters podcast.

Today we will be discussing the possibility of the release of 150K BTC onto the market and its effect it could have on the price of BTC. Next we'll look at DeFi protocol Aave's proposal to create a new stablecoin called GHO, and last we'll talk about Meta ditching their facebook login for a new metaverse ID system. Around the Blockchain is your favorite Cryptocurrency show discussing Bitcoin, Ethereum, Cardano, and the top altcoins. Our four crypto experts Jenna Kady, Crypto Lifer, Crypto Blood, & Ben Armstrong. Tune in for their insightful crypto analysis.

Andris Nelsons is Music Director of the Boston Symphony Orchestra and the the Leipzig Gewandhaus Orchestra. With both appointments, and in leading a pioneering alliance between these two esteemed institutions, Nelsons is widely considered as one of the most renowned and innovative conductors on the international scene today. In October 2020, the BSO and GHO jointly announced extensions to Mr. Nelsons' contracts. His contract with the BSO was extended until 2025, and his GHO contract until 2027. Tonight's BSO Opening Night concert begins with a benediction by Leonard Bernstein, a setting in Hebrew for baritone that was the composer's last work with orchestra; baritone Jack Canfield makes his BSO debut. The brilliant Chinese pianist Yuja Wang performs Franz Liszt's Piano Concerto No. 1. And Igor Stravinsky's revolutionary 1913 ballet score The Rite of Spring will be performed.