Podcasts about mev

Um paciente jovem, sem fator de risco clássico, chega com infarto. Ele não fumou, não tem colesterol alto, não é diabético. Mas relata uso frequente de maconha e bebidas alcoólicas.Neste episódio do DozeCast, Diandro e Thaysa mergulham em duas substâncias que acompanham a humanidade há milênios e que colocam o cardiologista moderno diante de decisões clínicas que exigem evidência, não moralismo. Da cerveja de 13 mil anos encontrada em rituais funerários à cannabis usada em cerimônias no Pamir há 2.500 anos, o episódio começa pela história para depois destrinchar, bloco a bloco, o que a ciência cardiovascular mais recente realmente mostra.

In this episode, Denny and paaao discuss everything about Vultisig: what it is, its token, future plans, and much more.Swap now https://swap.thorchain.org/ THORChain is a decentralized crypto exchange. THORChain is the first and biggest DEX for Bitcoin. You can use any self custody wallet to swap and there's no KYC required.Timestamps:00:00:00 Intro00:03:00 Paaao starts00:04:00 What is Vultisig?00:05:00 37 chains supported — Vultisig was born from THORChain MPC/TSS technology00:06:00 Every Vultisig user is a mini THORChain ecosystem00:08:00 When will we have a proper referral fee on all swaps, not just THORChain?00:12:00 What API is used? Is it OpenOcean for Solana meme coins?00:13:00 Is there an MEV component?00:14:00 How are swaps routed for maximum efficiency?00:17:00 How is Vultisig positioned to take advantage of everything that's coming?00:19:00 bRUNE support and the acquisition of Station Wallet00:20:00 Station is being converted into a fully agentic wallet!00:21:00 CCL on Rujira makes a great case for agentic use00:23:00 As soon as THORChain came back, people started swapping again00:25:00 MiCA consequences — people fleeing to self-custody00:26:00 How do we capture these users?00:28:00 Help us connect to communities, THORChads! Private keys are toxic!00:30:00 We have a sophisticated SDK that we are hardening — Hermes Agent00:31:00 Your agent can interact with other agents00:33:00 Vultisig is a return to proper self-custody00:35:00 Vultisig is building for the future00:38:00 Our goal is to make the wallet super easy — please let us know what can be improved!00:39:00 Self-hosting a Vultisig server could be powerful for businesses00:42:00 Could the VULT token become a universal in-app gas token?00:43:00 We'd need more centralized accounting — interesting idea00:45:00 We don't want to mix AI with wallet setup to reduce attack vectors00:47:00 Everyone can use Vultisig however they want, but self-hosting means maintaining your own app00:47:30 Vultisig Marketplace — developers can create automations00:48:00 For the first time, you can use custodial infrastructure to DCA through automated workflows00:49:00 We are focusing primarily on the agentic side rather than the marketplace00:51:00 Fee percentage question00:52:00 Is Vultisig hiring?00:53:00 Everyone is welcome to join Discord and open a PR, but we're not hiring full-time00:54:00 How safe are AI agents with Vultisig?00:55:00 We are focused on guardrails and multiple security layers for AI agents00:57:00 AI agents have been our biggest challenge00:58:00 Finding the balance between AI capabilities and guardrails is difficult01:00:00 Rujira support is coming soon!01:01:00 What makes you so excited about Rujira?01:02:00 Paaao loves lending, borrowing, and the liquidation engine01:03:00 The cross-chain capabilities are truly unique01:04:00 The connection between Rujira and Vultisig01:06:00 When XMR? Paaao: We're exploring how to add it01:08:00 MPC cryptography is difficult because we use DKLS01:09:00 MiCA regulations complicate the situation01:11:00 Is there anything else you'd like to talk about?01:12:00 Shout-out to the OGs: Try Vultisig again! It's changed a lot — send us feedback!01:13:00 Shared vaults for families, trust funds, and much more01:14:00 We want to improve communication — app releases every week01:16:00 Quai recommendation01:17:00 THORChain is a cockroach!

Are the visions of Jesus that people claim to have legitimate?Mike, Debi, and Nathan Pearl, with Shalom Brand answer questions sent in from viewersTimestamps00:18 How can you protect your kids in ministry?23:02 Is the MEV translation trustworthy?32:24 How can I forgive myself?40:39 Why doesn't God stop Israel from profiting from child abuse?1:00:15 Unbelieving wife of 40 years1:00:59 Was pastor Tony Spell right to defend his family with violence?1:09:39 Are visions of Jesus real?1:15:42 Thoughts on the show 'The Chosen'1:21:22 Daughter married to a man addicted to p*rn1:29:48 Does the counsel of the ungodly include the medical industry?

Today on Astronomy Daily: Japan's Hayabusa2 pulls off a nail-biting high-speed asteroid flyby, James Webb finds the same unexplained chemical mystery on Titan AND Pluto, a neutrino detector may have caught the universe's oldest supernova echo, a wild new theory tries to solve the black hole information paradox, we wrap up the weekend's aurora action, and we look at when NASA's New Horizons might finally cross into interstellar space.Monday, July 6, 2026 1. Hayabusa2's Flyby of Asteroid Torifune •        JAXA's Hayabusa2 spacecraft flew within ~800 metres of near-Earth asteroid (98943) Torifune on July 5, 2026, at a relative speed of about 5.25 km/s (~18,000 km/h). •        This is an extended-mission flyby, not a sample return — Hayabusa2 already delivered Ryugu samples to Earth in December 2020. •        Purpose: engineering demonstration of high-precision navigation relevant to planetary defense (asteroid deflection technology). •        Torifune is roughly 450 metres across. Next stop for Hayabusa2: rendezvous with asteroid 1998 KY26 in 2031. •        Source: JAXA/ISAS, Nikkei Asia, phys.org (July 5, 2026). 2. Mystery Molecule Found on Both Titan and Pluto •        James Webb Space Telescope data reveals an unexplained absorption feature at ~5.11 micrometres on the surfaces of Titan (Saturn's largest moon) and Pluto. •        Evidence points to a surface origin rather than atmospheric origin, based on limb-vs-disc-center comparison on Titan. •        Candidate compounds include allenes, but no confirmed identification yet. •        Pluto's absorption line is roughly three times broader than Titan's at the same central wavelength. •        Study led by Dr. Bruno Bézard's team (Paris Observatory); posted to arXiv June 11, 2026 — not yet peer-reviewed. 3. Super-Kamiokande's Hint of the Diffuse Supernova Neutrino Background •        Super-Kamiokande collaboration presented results at Neutrino 2026 (UC Irvine) after analyzing ~5,000 days of data. •        Found a statistically significant excess of events between 13.3–81.3 MeV — consistent with the long-predicted Diffuse Supernova Neutrino Background (DSNB). •        Significance: 2.6-sigma (~99.5% confidence) — below the 5-sigma discovery threshold, so described as an 'indication,' not a confirmed detection. •        If confirmed, DSNB would offer a new way to study the cosmic history of core-collapse supernovae via neutrinos rather than light. 4. A Theoretical Fix for the Black Hole Information Paradox •        New theoretical study proposes black holes stop evaporating just before vanishing completely, leaving a stable Planck-scale remnant (~9×10⁻⁴¹ kg). •        Mechanism: a repulsive force from spacetime torsion in a 7-dimensional Einstein-Cartan model, active at extreme (Planckian) densities. •        Proposal: quantum information is preserved via long-lived 'vibrations' in the remnant's internal torsion field. •        This is a theoretical/mathematical proposal, not an observational result. Researchers: Pinčák, Pigazzini, Pudlák, Bartoš. 5. Weekend Geomagnetic Storm / Aurora Wrap-Up •        X1.1 solar flare (June 30) and associated CME triggered a G3 (strong) geomagnetic storm around July 3–4, 2026. •        Aurora borealis visible as far south as Utah, Colorado, and Nevada in the continental US. •        NOAA SWPC reports conditions easing to unsettled/G1 levels through July 6 as CME effects wane. 6. Forecasting New Horizons' Crossing Into Interstellar Space •        SwRI researchers (lead: Dr. Jonathan Gasser) combined solar wind forecasting with heliosphere models to predict New Horizons' termination shock crossing. •        Forecast window: 2029–2040, with possible multiple crossings as the heliosphere expands/contracts with the solar cycle. •        New Horizons is currently ~66 AU from the Sun. Voyager 2 crossed its termination shock at 84 AU in 2007, with a 46% solar wind speed drop. •        New Horizons would become only the third spacecraft (after Voyager 1 and 2) to cross this boundary. •        Two papers: Advances in Space Research and The Astrophysical Journal (SwRI, 2026).Become a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-the-latest-space-news--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

In this special episode, we revisit a fireside conversation between Vitalik Buterin and Friederike Ernst at DappCon 2026 in Berlin. They explore the Ethereum Economic Zone (EEZ), a new vision for Ethereum built around synchronous composability, app chains, and real-time proving.Following the fireside, Sebastien and Friederike break down the ideas behind the EEZ and discuss what this new paradigm could mean for Ethereum's future.Topics covered include:• The Ethereum Economic Zone and synchronous composability• App chains, privacy networks, and prediction markets• Ethereum as an economic operating system for the internet• Sequencing, MEV, and shared liquidity across chains• Enterprise, government, and institutional use cases• Why this approach differs from Cosmos, Polkadot, and other ecosystem visions• The future of Ethereum beyond rollup fragmentationLinks:Lido: https://lido.fi/stvaults?mtm_campaign=epicenterSponsors: Lido V3 introduces stVaults: a modular staking infrastructure that lets builders and institutions deploy custom staking vaults, while staying anchored to stETH as a shared liquidity layer.Get started building with Lido V3 today: https://lido.fi/stvaults?mtm_campaign=epicenterBlock Space Forum: https://blockspace.forum/NEAR AI Cloud now lets developers deploy OpenClaw—the rapidly growing open-source AI agent platform—inside Trusted Execution Environments, providing hardware-level encryption with cryptographic attestations. With OpenClaw on NEAR AI Cloud, you can run agents with cloud convenience, but without traditional cloud data exposure. No hardware to manage. No trust assumptions required. Learn more at near.ai.

Dor torácica em rasgando, início súbito, irradiando para o dorso. É isso que os livros ensinam, mas não é só isso que você vê na vida real. E o tempo, nesse caso, é o seu maior inimigo: a mortalidade pode chegar a 1 a 2% por hora nas primeiras 24 a 48 horas.Neste episódio, recebemos o Dr. Vinícius Correia, cardiologista do Incor-SP e do Hospital Sírio-Libanês, para destrinchar o manejo das Síndromes Aórticas Agudas com base nas diretrizes mais recentes da ESC 2024 e ACC/AHA 2022. Um tema subdiagnosticado, extremamente letal, e que exige raciocínio rápido à beira-leito.

 EPISODE DESCRIPTION I sat down with Pasha from Igra Labs in Berlin to dig into one of the most contrarian bets in Web3 right now , EVM on proof of work. Pasha walks me through why he left the Ethereum ecosystem, what drew him to Kaspa's BlockDAG architecture, and why he believes proof of work offers something proof of stake simply cannot: real fairness. We get into MEV resilience, censorship resistance, and why 10 blocks per second with no centralized sequencer changes everything for DeFi builders. We also cover Multitude, their brand new sovereign execution zones product, and why AI agents might finally be the user experience layer that makes Web3 click for everyone. If you're a founder, a builder, or just someone curious about where the next wave of adoption is coming from, this one is packed.  CONNECT Igra Labs Website: https://igralabs.com/heroDeploy your sovereign finance chain infrastructure https://igralabs.com/multitude Igra Labs Twitter/X: https://x.com/Igra_LabsPavel LinkedIn: https://www.linkedin.com/in/emdin/Web3 with Sam Kamani Podcast: https://www.web3pod.xyz/ KEY POINTS WITH TIMESTAMPS • [00:30] Introduction to Pasha from Igra Labs and what the episode covers• [01:51] Pasha's backstory , from Delivery Hero and Auto One to falling into crypto in 2017• [03:24] The core problem Igra Labs is solving: bringing EVM to proof of work via the Kaspa BlockDAG• [05:53] Why proof of work still makes sense , decentralization, security, and hardware commitment• [07:47] MEV resilience and front-run resistance as the killer property of EVM on proof of work• [09:44] Real use cases: stablecoins, DeFi, RWAs, and AI agentic settlement on Igra• [12:39] How EVM makes it easy for developers , Solidity tooling, SDKs, and AI coding agents• [14:26] Developer onboarding in minutes using a single GitBook link and an AI agent• [16:26] Introducing Multitude , sovereign execution zones allowing teams to launch their own Igra• [18:52] How Multitude differs from parachains, appchains, and L2 models like OpStack• [21:25] Where Web3 goes next , AI agents as the UX layer that finally unlocks mass adoption• [24:48] An agentic marketplace being built on Igra , like Upwork, but for AI agents• [27:02] What Pasha would do differently if starting Igra Labs today• [27:52] Current asks: design partners for Multitude, a small strategic round, and ambitious buildersDISCLAIMERNothing mentioned in this podcast is investment advice and please do your own research. It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend. Be a guest on the podcast or contact us - ⁠https://www.web3pod.xyz/

An anti-MEV activist spent weeks building 66 fake contracts to trap the sandwich bot jaredfromsubway.eth. Then jared's operators did the one thing nobody expected. ======================================================== Thank you to our sponsors! Cape: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at https://cape.co/unchained (use code: UNCHAINED). ======================================================== A new R&D lab called Ethlabs has split from the Ethereum Foundation, backed by Bitmine and Joe Lubin. Its first stated goal is solving a '15 minute finality problem' that none of the hosts can quite explain the point of. Kain Warwick, Taylor Monahan, and Luca Netz ask whether a breakaway staffed largely by ex-EF people can really escape the EF's habits, or just rebuild a smaller version of them.  Then the conversation turns to fomo's $75M raise from non-crypto VCs, and why a trading app that never calls itself a wallet may have cracked the onboarding flow the rest of crypto keeps getting wrong. The hosts also trace a CryptoPunks judge ordering a self-represented plaintiff to handwrite filings to stop the AI slop, the anti-MEV activist who trapped sandwich bot jaredfromsubway.eth with 66 fake contracts, and the WSJ's claim that Polymarket paid creators to stage fake winning bets. Hosts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kain Warwick⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Founder of Infinex and Synthetix ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Taylor Monahan⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Security Expert ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Luca Netz⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, CEO of Pudgy Penguins Timestamps

An anti-MEV activist spent weeks building 66 fake contracts to trap the sandwich bot jaredfromsubway.eth. Then jared's operators did the one thing nobody expected. ======================================================== Thank you to our sponsors! Cape: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at https://cape.co/unchained (use code: UNCHAINED). ======================================================== A new R&D lab called Ethlabs has split from the Ethereum Foundation, backed by Bitmine and Joe Lubin. Its first stated goal is solving a '15 minute finality problem' that none of the hosts can quite explain the point of. Kain Warwick, Taylor Monahan, and Luca Netz ask whether a breakaway staffed largely by ex-EF people can really escape the EF's habits, or just rebuild a smaller version of them.  Then the conversation turns to fomo's $75M raise from non-crypto VCs, and why a trading app that never calls itself a wallet may have cracked the onboarding flow the rest of crypto keeps getting wrong. The hosts also trace a CryptoPunks judge ordering a self-represented plaintiff to handwrite filings to stop the AI slop, the anti-MEV activist who trapped sandwich bot jaredfromsubway.eth with 66 fake contracts, and the WSJ's claim that Polymarket paid creators to stage fake winning bets. Hosts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kain Warwick⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Founder of Infinex and Synthetix ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Taylor Monahan⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Security Expert ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Luca Netz⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, CEO of Pudgy Penguins Timestamps

O coração estava perfeito na autópsia. E mesmo assim foi a causa de óbito do atleta. Como isso é possível e por que isso muda tudo o que achávamos saber sobre morte súbita no esporte?Neste episódio, Fernanda Justo e Mateus Prata recebem a Dra. Luciana Janot para desmontar, ponto a ponto, o que há de mais atual sobre emergências cardiovasculares no esporte, unindo ACC/AHA 2025, ESC 2020, SBC/SBMEE 2019 e o novo Posicionamento SBC de Emergências em Eventos Esportivos (2026).

 EPISODE DESCRIPTION In this episode, I sit down with Milos, Lead Engineer at Enso, live at Berlin Blockchain Week. We dig into the real problem holding back DeFi builders, complexity. Audits cost hundreds of thousands of dollars, bridges are a nightmare, and integrating protocols is a full-time job on its own. Enso is tackling all of that with a single API that handles routing, security, and DeFi actions across 100-plus protocols, so developers and agents can just build. We also get into the RWA boom, the current state of AI agents in Web3, and why Milos thinks we should never forget where DeFi came from. DISCLAIMERNothing mentioned in this podcast is investment advice and please do your own research. It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend. Be a guest on the podcast or contact us - https://www.web3pod.xyz/ CONNECT Enso Website:https://www.enso.build/Enso Twitter/X: https://x.com/EnsoBuildEnso LinkedIn: https://www.linkedin.com/company/enso-build/Milos LinkedIn: https://www.linkedin.com/in/miloscostantini/Web3 with Sam Kamani: https://www.web3pod.xyz/ KEY POINTS WITH TIMESTAMPS • [00:00] Milos explains the core problem Enso solves: complexity for DeFi developers• [01:33] Milos's personal journey from mining Bitcoin as a student in 2016 to writing his thesis on Ethereum• [03:13] How smart contract development has and hasn't changed over the years• [06:00] How Enso's API removes the need for developers to deploy integration contracts or manage bridges• [07:00] Built-in security defaults, like MEV protection on DEX swaps, that come with Enso• [07:53] Why using Enso means you don't need your own smart contract audit• [09:36] The biggest trend Enso is seeing: RWA and tokenized stocks• [10:43] How Enso lets users buy tokenized stocks using any token from any chain• [11:40] Flash loan aggregator and looping positions, what's coming next• [12:05] How Enso makes money through fee-split partnerships with integrators• [13:00] The long-term vision: becoming the most composable orchestration layer in DeFi• [14:29] Milos's take on the current hardening era for DeFi and the rise of hacks• [16:38] His most contrarian view: don't forget Web3's roots in permissionless experimentation and values• [18:23] Notable projects built on Enso including Yearn, EtherFi, and the Boiko Layer 0 migration• [20:44] Advice for builders: don't give up, explore on-chain options protocols• [22:28] Enso is profitable and actively hiring

Matt opens the show with a Father's Day recap, a local car show, and a reminder that some classic American cars still turn heads decades later. He then dives into growing concerns around Strategy's Bitcoin financing model, explaining why the company's preferred stock performance matters for its ability to continue accumulating Bitcoin and supporting the broader treasury-company narrative.The episode also explores the escalating battle over stablecoin regulation, from the Bank of England's new framework to the ongoing fight between federal and state oversight in the United States. Matt discusses the tension between state-level competition and national regulatory consistency, while examining new compliance requirements being proposed for stablecoin issuers.Finally, Matt covers the latest crypto security breaches, including exploits affecting Taiko and the JaredFromSubway.eth MEV bot, highlights a Japanese pension fund allocating capital to crypto, and reflects on how the industry's biggest debate may no longer be about Bitcoin itself, but about who controls the financial rails being built around stablecoins and digital assets.Happy Hodling, Everyone. Hosted on Acast. See acast.com/privacy for more information.

Taiko suffers a state verification compromise. A native zkEVM can scale bandwidth and execution. A new proposal seeks to redirect validator rewards to ecosystem funding. And an MEV bot gets hacked in a honeypot scheme. Read more: https://ethdaily.io/973 ETH Daily sponsorships are now open. Reach over 10,000 Ethereum-native subscribers every weekday. Learn more at ethdaily.io/ads Disclaimer: Content is for informational purposes only, not endorsement or investment advice. The accuracy of information is not guaranteed.

In this episode, Austin chats with Mert about why privacy is becoming essential for crypto and on-chain finance. They discuss how ZK-based privacy works via shielded pools, commitments, proofs, and nullifiers, contrasting it with Monero's probabilistic obfuscation. Mert explains Zcash's renewed adoption through improved usability, macro and regulatory shifts, and fairer historical distribution. He argues privacy layers fail when they lack tangible benefits, and outlines a new fully on-chain, composable, atomic privacy protocol for Solana built with Light Protocol's compression approach, including permissionless and enterprise “zones” with configurable compliance features and reduced MEV via encrypted swaps.  00:00 - Why Privacy Matters  03:05 - Zcash And ZK Origins  06:26 - How Shielded Pools Work  09:56 - Why Zcash Broke Out  15:52 - Why Privacy Layers Fail  19:47 - Solana Privacy Protocol  22:57 - Composability Breakthrough  25:51 - Go-To-Market Plan  30:50 - Compliance And Zones  32:40 - Onchain Versus Off Chain  34:58 - Zcash And Solana's Future  40:29 - Bitcoin Privacy And Quantum  43:48 - Closing And Where To Find Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Você otimizou o LDL. Chegou na meta de ApoB. E o paciente volta meses depois com um novo evento. Neste episódio especial, com apoio da Novo Nordisk, Diandro Mota e William Batah recebem o Dr. Eduardo Lima, doutor em Cardiologia pela USP, professor colaborador e supervisor da Residência em Cardiologia da FMUSP/InCor e Head Nacional de Cardiologia da Rede Américas, para uma conversa que pode redefinir como você enxerga o risco residual. A tese é direta: a aterosclerose nunca foi só uma doença de colesterol. Ela é imunometabólica, e a inflamação subclínica pode ser o elo que faltava.O que você vai aprender:

Durante anos, o cardiologista que atendia um paciente com ICFEp tinha poucas ferramentas: diurético para o sintoma e tratamento das comorbidades. Enquanto a ICFEr ganhou o Quarteto Fantástico com redução de 64% em mortalidade e hospitalização, a ICFEp acumulava estudo negativo atrás de estudo negativo. CHARM-Preserved, I-PRESERVE, PEP-CHF, TOPCAT ficaram no “quase”, mas não atingiram ápice no quesito robustez de evidência para beneficios.No Ep. 227 do DozeCast, os hosts Plínio Wolf e Victor Bemfica convidaram a Dr. Mariane Higa (chefe do setor de ICFEp do Dante Pazzanese) para abrilhantar a mesa de especialistas em insuficiência cardíaca que convivem com os dilemas da ICFEp todos os dias: da epidemiologia e fisiopatologia à fronteira terapêutica atual.O que você vai aprender:

Seu paciente chega no consultório com um vidro de ômega-3 importado e te olha esperando confirmação: "é bom pro coração, né, doutor?" Durante décadas, a resposta foi automática. Hoje, ela precisa de mais cuidado, e de evidência.Nesse episódio, Mateus Prata e Raphael Rossi mergulham de cabeça na história do ômega-3 e risco cardiovascular: da expedição dos anos 1970 à Groenlândia até o PISCES, publicado no NEJM em 2025. Um episódio que vai te fazer repensar o que você diz (e prescreve) no consultório.O que você vai aprender:

A coronariografia veio normal. Mas o paciente continua com dor, teste isquêmico positivo e qualidade de vida no chão. O que você está deixando de investigar?Neste episódio, Mateus Prata e Raphael Rossi mergulham na fisiologia invasiva da microcirculação coronariana — o território que a angiografia simplesmente não enxerga. Falamos sobre INOCA, ANOCA, disfunção microvascular e espasmo coronariano: por que esses diagnósticos ainda escapam e como o teste fisiológico invasivo pode mudar o rumo clínico de forma concreta.

In this episode, I sat down with functional practitioner and Mountain Metabolic Coach Mehvish Khan to talk about the deeper connection between hormones, gut health, stress, metabolism, and fat loss. We break down what actually matters for women's health, why symptoms shouldn't be ignored, and practical ways to support your body without falling into extremes.Connect with Mev on Instagram @coach_mev Mountain Metabolic Coaching [Application Link] — Fat loss, body recomposition, nutrition, hormones, performance, all with full 1:1 coach support. Fit For Hiking Guides  — Workouts to get you trail-ready.More Resources — Wellness tips, hiking + travel guides, and blogs.Shop My Favorite Gear — Amazon storefrontFit For Hiking Instagram Bradee Instagram 

Dr. Lorenzo Tomé conversa com Bruno Colantoni, cardiologista e presidente do Colégio Brasileiro de Medicina de Estilo de Vida (CBMEV), sobre uma das transições mais importantes da medicina contemporânea: sair do modelo de tratar doenças para construir saúde de fato, e o que isso significa para a carreira e o consultório do médico. O episódio parte de um dado que não dá pra ignorar: 75% das mortes no Brasil e no mundo vêm de doenças crônicas não transmissíveis, e o modelo de consulta avulsa não foi feito para tratar esse perfil de paciente. A conversa passa pela origem da especialidade nos Estados Unidos, pelos seis pilares da MEV, pela ciência da mudança de comportamento e pelo processo completo de certificação internacional. Mas também vai além disso trazendo a discussão sobre por que o paciente paga caro pela caneta emagrecedora e não paga pela consulta, o que isso revela sobre percepção de valor, e como o médico pode reposicionar a sua entrega dentro de um mercado de wellness que movimenta R$ 100 bilhões por ano no Brasil. Se você já sabe que precisa entregar mais ao paciente, mas ainda não encontrou a estrutura clínica e de negócio para fazer isso, esse episódio aponta o caminho. O background do Bruno Colantoni Bruno Colantoni é médico cardiologista formado pela Faculdade de Medicina de Marília, com residência em Clínica Médica, Cardiologia e Ecocardiografia pela Unicamp. Construiu carreira como cardiologista clínico, sócio de clínica própria, e ao longo do processo viveu na pele a transformação que hoje ensina: partiu de um quadro de obesidade, sedentarismo e triglicérides de 700 mg/dL para emagrecer 30 kg e descobrir, a partir da própria experiência, o impacto real dos hábitos de vida nos desfechos clínicos. Em 2018, participou de um curso de Lifestyle Medicine em Harvard, onde teve contato com os fundadores do Colégio Brasileiro de Medicina de Estilo de Vida. Desde então, dedica sua carreira à difusão e consolidação da MEV no Brasil, hoje como presidente do CBMEV e parceiro estratégico da SD Escola na capacitação dos médicos em medicina de estilo de vida. Entre na Comunidade SD no WhatsApp e tenha conteúdo gratuito todos os dias sobre negócios médicos. Acesse Assista esse episódio também em vídeo no Youtube no nosso canal Saúde Digital Podcast! Acesse os episódios anteriores! SD358 - Upsell ético no consultório: mercado de wellness sem "empurroterapia" SD357 - As consultas avulsas estão falindo SD356 - O que ninguém lhe ensinou sobre sucessão na medicina Musica: Declan DP - Climb Music © Copyright Declan DP 2018 - Present. https://license.declandp.info | License ID: DDP1590665  

A síncope vasovagal sempre foi um dos maiores desafios da cardiologia clínica e da eletrofisiologia.Mas será que estamos entrando em uma nova era no tratamento desses pacientes?Neste episódio do DozeCast, recebemos o Dr. Juan Zerpa — presidente da LAHRS, eletrofisiologista pela SOBRAC e uma das maiores referências em cardioneuroablação na América Latina — para discutir uma técnica que vem transformando o manejo de pacientes com síncope vasovagal cardioinibitória e bradiarritmias funcionais.Falamos sobre fisiopatologia, seleção de pacientes, técnica do procedimento, evidências atuais, limitações e o grande debate: a cardioneuroablação pode evitar um marca-passo em pacientes selecionados?O que você vai aprender:

幻冬舎の暗号資産（仮想通貨）/ブロックチェーンなどWeb3領域の専門メディア「あたらしい経済 https://www.neweconomy.jp/ 」がおくる、Podcast番組です。 ーーーーー 【番組スポンサー】 この番組は、暗号資産取引におけるフルラインナップサービスを提供する「SBI VCトレード」のスポンサーでお届けします。 ーーーーー SBI VCトレードは、「暗号資産もSBI」のスローガンのもと、国内最大級のインターネット総合金融グループであるSBIグループの総合力を生かし、暗号資産取引におけるフルラインナップサービスを提供しております。暗号資産交換業者・第一種金融商品取引業者・電子決済手段等取引業者として高いセキュリティ体制のもと、暗号資産の売買にとどまらない暗号資産運用サービスや法人向けサービスの展開、さらにステーブルコインのユーエスディーシー（USDC）を国内で初めて取り扱っております。 ーーーーー SBI VCトレード公式サイト：https://account.sbivc.co.jp/signup?hc_ak=1RNML.3.M06AS ーーーーー 【紹介したニュース】 ・日本ブロックチェーン基盤、信託型の円ステーブルコイン「EJPY」発行へ ・インタートレードら、国産HWウォレットとFireblocks統合の資産管理基盤を商用化へ ・米上院、暗号資産市場構造法案「CLARITY法」修正版公開。14日に委員会採決へ ・イーサリアム財団、「ブラインド署名」対策で新標準。昨年のバイビットハックなど背景に ・アプトスラボ、MEV対策で「暗号化メモリプール」提案。イーサリアムでも研究が進む領域 ・スタークネット、プライバシー対応ビットコイン「strkBTC」公開。シールド送金に対応 ・米国初、「ハイパーリキッド（HYPE）」現物ETFがナスダック上場、21シェアーズ組成 ・クラーケン親会社ペイワードとフランクリン・テンプルトン提携、トークン化運用商品をオンチェーン展開へ ・ムーンペイ、AI・金融市場系研究のドーンラボ買収、AI取引ツール提供開始 ・MARA、15億ドル規模のビットコイン売却。AIデータセンターへ本格転換 ・サークル、独自L1「Arc」のトークンで約3.2億ドル調達。a16zやブラックロックら参加 ・クリプトドットコム、UAEで非現金型決済サービスの「SVFライセンス」取得 【あたらしい経済関連リンク】 ニュースの詳細や、アーカイブやその他の記事はこちらから https://www.neweconomy.jp/

Por décadas, o café entrou no consultório como suspeito. Arritmogênico, hipertensor, possível gatilho de morte súbita. Em 2025, um ensaio randomizado publicado na JAMA virou essa narrativa de cabeça para baixo, e os dados são mais fortes do que você imagina.Neste episódio, o DozeCast convida o Dr. Bruno Mioto, cardiologista com doutorado em café e saúde cardiovascular, e Matheus Dominguito, um dos grandes produtores de café no Brasil, para uma conversa que mistura evidência clínica de alto nível com a arte de fazer uma boa xícara. Foram poucas as vezes em que a cardiologia e a cultura do café se encontraram tão bem.O que você vai aprender:

On the ground at Solana Accelerate Miami 2026, we interviewed builders and innovators shaping the future of Web3.Guest: Lucas Bruder Co-Founder & CEO of Jito LabsJTX Waitlist ➜ https://bit.ly/JTXtrade00:00 intro00:08 Jito Labs00:16 JTX Announcement01:02 Moving away from Infrastructure02:24 JTX vs Jupiter Exchange03:25 Lending & Borrowing04:10 Not a DEX04:45 Solana Focus05:33 Upgrading Jito & Solana For Traders08:08 Pro-Traders vs Retail Adoption09:22 Prediction Markets on Solana10:22 MEV on Solana11:56 outro#Crypto #solana #Ethereum~Solana's New CEX Killer?

In this episode, host Friederike Ernst is joined by Kubi Mensah, CEO and co-founder of Gattaca, the company behind Titan Builder. Kubi sheds light on the highly competitive and often opaque world of Ethereum block building, explaining how Gattaca evolved from a centralized exchange proprietary trading firm to one of the three dominant builders responsible for constructing the vast majority of Ethereum blocks today .  They dissect the true "journey of a transaction," revealing why over half of all Ethereum transaction value bypasses the public mempool in favor of private order flow auctions and MEV-protection services . Kubi explains the intricate mechanics of top-of-block bidding by high-frequency DeFi arbitrageurs, the necessity of extreme latency optimization, and the "flywheel effect" that makes block building a natural oligopoly . Finally, the discussion turns to the future of the Ethereum roadmap, unpacking how upcoming upgrades like ePBS (enshrined Proposer-Builder Separation) and FOCIL (Fork-Choice Enforced Inclusion Lists) aim to permanently alter the power dynamics between block builders, validators, and originators .  Topics04:15 Transitioning from TradFi Trading to Ethereum Block Building09:30 Redefining the Builder: Relays and Order Flow Auctions15:00 Unpacking the Mempool: Public vs. Private Transactions21:45 The Anatomy of a Block & "Top-of-Block" Arbitrage27:10 How Builders Pay Proposers to Win Auctions35:20 The Oligopoly: Why Only 3 Builders Dominate Ethereum42:15 Trust in the Dark Forest: Handling Searcher Bundles49:00 The Convergence of Builders and Solvers55:30 The Impact of ePBS, FOCIL, and Pre-confirmationsSponsors: Lido V3 introduces stVaults: a modular staking infrastructure that lets builders and institutions deploy custom staking vaults, while staying anchored to stETH as a shared liquidity layer.Get started building with Lido V3 today: https://lido.fi/stvaults?mtm_campaign=epicenterBlock Space Forum: https://blockspace.forum/

Os 10 ensaios clínicos do ACC.26 que você precisa conhecer – discutidos por quem entende.Neste episódio especial do DozeCast, William, Rapha e Plínio se reúnem para destrinchar os principais Late-Breaking Trials apresentados no American College of Cardiology 2026 – o congresso que pautará a cardiologia mundial nos próximos meses.Da revascularização de oclusões crônicas (ORBITA-CTO) à decisão entre TAVI e angioplastia ( PRO-TAVI), passando pela prevenção cardiovascular (VESALIUS), insuficiência cardíaca (SPIRIT-HF, DIG- RHD),  oclusão do apêndice atrial (CHAMPION), tromboembolismo pulmonar de alto risco (HI-PEITHO) e muito mais! Cada estudo é analisado com olhar clínico, crítico e aplicável ao dia a dia.Se você quer sair do episódio sabendo o que mudou, o que confirmou e o que ainda gera dúvida após o ACC.26, esse é o conteúdo definitivo.

After 15 years of being a Bitcoin-only maximalist and about a decade of promoting BIP300 as a soft fork, LayerTwo Labs CEO Paul Sztorc decided to launch Ecash: a hard fork of Bitcoin in which every BTC holder gets free coins. There's a catch, though: while everyone can claim 1 ecash for every bitcoin that they own, Satoshi can only claim half. Meaning that a returning Satoshi will only be able to claim half his coins, while the other half (550k) is currently being sold to investors in order to fund the development and bootstrapping of Ecash. What's more controversial: the hard fork or the SHAD (Satoshi Half Air Drop)? Only time will tell. But the Ecash hard fork is scheduled to happen in August 2026... unless Bitcoin activates BIP300 in the meantime. Game theory at its finest! Time stamps: 00:00:58 – Paul Sztorc announces the new Bitcoin hard fork project, eCash, sharing his motivation for launching it and setting the stage for the discussion. 00:03:02 – eCash's technical details are explained, including its smaller 400kB block size and the integration of drivechains (BIP 300) to enhance scalability and flexibility. 00:04:55 – The initial drivechains launching with eCash are described, such as Thunder for scalability, ZSide for privacy, and additional chains like CoinShift, BitNames, and Photon. 00:09:28 – Security aspects of sidechains are discussed, covering the 256 sidechain limit, potential outcomes if sidechains fail, and the risks users face when moving coins. 00:14:26 – The project's name, Ecash, is revealed, with a comparison to Bitcoin Cash and an explanation of the naming decision. 00:15:40 – Paul delves into the philosophy behind the hard fork, his views on Bitcoin maximalism, and his intention to remain committed to both Bitcoin and eCash. 00:20:35 – Mining dynamics are explored, including SHA256 mining competition, miner incentives, and the potential for MEV (miner extractable value) issues. 00:22:36 – Paul critiques the current state of Bitcoin, highlighting user and developer frustration, stagnation, low transaction fees, and gridlock in development. 00:29:40 – The potential for eCash to attract frustrated Bitcoin builders is considered, with references to similar migrations in crypto history. 00:31:38 – Ethereum's rise is analyzed as a consequence of Bitcoin's block size wars, with discussion on missed opportunities and lessons learned. 00:41:06 – The likelihood and impact of further Bitcoin hard forks are speculated upon, focusing on community fragmentation and effects on value. 00:41:49 – Hard forks are framed as healthy competition that benefits investors by providing free coins and stimulating innovation. 00:48:20 – The decision to reassign half of Satoshi's coins for development and community incentives is explained, addressing concerns about distribution. 00:54:07 – Quantum computing threats, Satoshi's mining behavior, and the rationale for the coin distribution are discussed in the context of long-term security. 01:36:00 – Users are advised to self-custody their Bitcoin to claim eCash, with an outline of the claiming process and best practices. 01:39:01 – Technical steps for claiming eCash using private keys are detailed, including wallet compatibility and the process for users. 01:43:26 – The potential for NFT and ordinal activity on eCash is addressed, along with how LayerTwo Labs will manage onboarding and network congestion. 01:45:35 – Drivechain security parameters are confirmed, with eCash using a 13,000-block security window in line with BIP 300's Bitcoin implementation. 01:52:06 – The transition from a centralized project launch to decentralized development and governance. 01:54:36 – The current developer team size (about nine members) is shared, along with incentives for external developers to contribute to eCash. 01:58:26 – eCash is compared to Bitcoin Cash, with discussion on network effects, competition, and the potential for eCash to drive improvements in Bitcoin. 02:07:22 – The session concludes with future plans, a call for community engagement, and the possibility of follow-up discussions as the project evolves.

Fibrilação atrial, palpitações, hipertensão sistólica isolada, bradicardia, derrame pericárdico, dislipidemia refratária, insuficiência cardíaca sem causa clara. Quantas vezes o problema pode estar na tireoide e o cardiologista deixa passar?Neste episódio do DozeCast, Victor Bemfica e Thaysa Lousada discutem a relação entre tireoide e coração em uma conversa prática, clínica e extremamente útil para quem atende pacientes no mundo real. A proposta do episódio é simples: mostrar por que a tireoide não pode ser tratada como detalhe laboratorial quando o sistema cardiovascular está em jogo.

In this episode, Austin chats with Rahul Jain (Head of Trading at Ellipsis Labs) to explore the evolution of market making in crypto. Rahul discusses what gives crypto market makers an edge, why being early matters, and how crypto has created new challenges around MEV, transaction landing, and execution. They explore the future prospects of prop AMMs, perps, MCP, and what it will take for on-chain finance to scale beyond crypto-native users and compete with traditional markets.    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Seu paciente tem LDL alto, risco cardiovascular elevado e não tolera estatina. O que você prescreve?Neste episódio do DozeCast, o Mateus Prata e a Raquel Rios fazem uma imersão completa no ácido bempedoico: da farmacologia molecular ao maior ensaio clínico já desenhado exclusivamente para intolerantes a estatinas. Se você ainda não incorporou essa droga na sua prática, esse é o episódio que vai mudar isso.O que você vai aprender nesse episódio:

I spoke to Luis Bezzenberger of Brainbot and core contributor to Shutter Network, about MEV and threshold encryption for encrypted mempools.Luis comes from a background in distributed systems and has spent years thinking about how cryptography can level the playing field between ordinary users and sophisticated actors who exploit the transparency of public mempools. We dig into how threshold encryption works, why encrypted mempools like what Shutter Network is building, could protect users from front-running without sacrificing decentralization, and what it actually takes to get something like this shipped at the protocol level. We also get into the broader architecture puzzle — encrypted mempools PBS, FOCIL, and why Luis thinks these three pieces together form the holy trinity for censorship resistance on Ethereum.This episode is sponsored by NYM, the world's most private VPN. Unlike traditional VPNs, Nym uses a decentralized mixnet to scramble your internet data — hiding who you're talking to, when, and how often. You can switch between full mixnet mode for maximum anonymity, or a faster VPN mode for everyday use.Use the code blockchainsocialist when signing up and get an extra month!If you liked the podcast be sure to give it a review on your preferred podcast platform. If you find content like this important consider donating to my Patreon starting at just $3 per month. It takes quite a lot of my time and resources so any amount helps. Follow me on Twitter (@TBSocialist) or Mastodon (@theblockchainsocialist@social.coop) and join the r/CryptoLeftists subreddit. Support the showICYMI I've written a book about, no surprise, blockchains through a left political framework! The title is Blockchain Radicals: How Capitalism Ruined Crypto and How to Fix It and is being published through Repeater Books, the publishing house started by Mark Fisher who's work influenced me a lot in my thinking. The book is officially published and you use this linktree to find where you can purchase the book based on your region / country.

Crypto News: Treasury Secretary Scott Bessent calls for the crypto market structure bill Clarity Act to be passed asap. Trump will attend meme coin event. XRP adjacent Flare proposes protocol-level MEV capture and 40% inflation cut.Brought to you by

Você já se deparou com um paciente com insuficiência cardíaca francamente descompensada, apesar de achados ecocardiográficos estruturais pouco exuberantes — fração de ejeção preservada, câmaras de dimensões normais e espessura ventricular sem alterações significativas? Pensou em pericardite constritiva? E, mais do que isso, sentiu segurança para interpretar achados como annulus reversus, septal bounce e septal shift?Neste episódio, vamos desvendar a pericardite constritiva: do diagnóstico clínico à interpretação da multimodalidade de imagem, sempre com base na compreensão da fisiopatologia da doença — elemento central para reconhecer seus achados e conduzir o caso de forma adequada. Também discutiremos o tratamento individualizado, seja ele clínico, invasivo ou combinado.Ao longo da conversa, mostraremos que, na pericardite constritiva, nada é absoluto: o pericárdio nem sempre está espessado, nem sempre está calcificado, e a constrição nem sempre é irreversível.Embora relativamente rara, a pericardite constritiva tem grande impacto prognóstico quando não é reconhecida e manejada corretamente. Isso é especialmente relevante porque a insuficiência cardíaca secundária à constrição pode, sim, ser reversível — desde que o diagnóstico e o tratamento sejam feitos no momento certo.O que você vai aprender neste episódio:

Don Wilson, founder and CEO of DRW, said Wall Street firms are unlikely to adopt fully transparent public blockchains. Canton continues is FUD against permissionless blockchains like Solana and Ethereum in order to gain traction on their new Citadel-backed network of incumbents.GUEST: Rebecca Rettig, CLO at Jito LabsFollow Rebecca on X ➜ https://x.com/RebeccaRettig1Liquid Stake on Jito ➜ https://www.jito.network/00:00 intro00:30 Canton not an institutional chain?01:10 Small Startups?01:35 Citadel backs Canton02:12 Don Wilson vs Solana and ETH02:55 So it is an institutional chain03:09 Rebecca Fires Back at Solana FUD03:41 Yuval insults Rebecca04:09 Canton twitter war drama04:53 Rebecca Rettig on MEV vs TradFi07:08 Paul vs Yuval on DTCC & Citadel 09:01 Reg-NMS Law enables opaque Wallstreet11:02 Crypto Kill Switch proposals12:49 Vibhu: Why Memecoins are important14:19 Drift Hack & Cybersecurity15:59 Lightning Round16:22 Robinhood Coincidence16:46 Canton desperate18:03 Jito vs Citadel18:42 Uniswap & Jito Auctions19:17 JitoSOL19:46 Canton not worth hacking20:21 More corpo chains coming21:44 CLARITY vs Solana22:15 outro#Crypto #Solana #Canton~Institutions & Retail Want Solana... not Canton

VO₂máx virou o queridinho da longevidade e performance. Mas o que a evidência realmente diz sobre ele?Nesse episódio do DozeCast, Mateus Prata, Fernanda Justo e Thaysa Louzada recebem o Dr. Silvio Póvoa para destrinchar, de ponta a ponta, o que o VO₂ pode (e o que ele não pode) dizer sobre o seu paciente. Um tema que saiu dos laboratórios de fisiologia, passou pelo consultório de cardiologia e chegou ao pulso de todo mundo via wearables. E que merece ser discutido com rigor.O que você vai aprender nesse episódio:

We break down the transaction pipeline from validators to builders, explore the risks of today's order flow systems, and unpack how encrypted mempools aim to reduce MEV, improve privacy, and strengthen censorship resistance. Featuring Luis Bezzenberger from Shutter Network and Julian Ma from the Ethereum Foundation's Robust Incentives Group, the conversation dives into EIP-8184 (LUCID), its design, tradeoffs, and what it means for the future of Ethereum market structure. If you care about MEV, decentralization, and the path to low-risk DeFi, this is a must-listen! Follow @bezzenberger and @_julianma on X

At the Digital Asset Summit 2026 in New York, a key question came up: what do banks actually need from blockchain? The answer isn't speed or hype — it's privacy, compliance, and protection from front-running. In this episode, Peter breaks down why public chains like Ethereum and Solana fall short for institutional use, and where Cardano and Midnight fit into the picture.The episode covers the three core requirements institutions have — selective disclosure, execution predictability, and compliance tooling — and explains why neither Ethereum nor Solana can deliver on all three natively. Peter walks through how MEV (maximal extractable value) creates a hidden tax on public chains, why that's a dealbreaker for banks moving serious capital, and how Midnight's programmable privacy using zero-knowledge proofs offers a fundamentally different approach.The broader Cardano ecosystem also gets a look-in: Leios for scaling, Layer 0 for cross-chain connectivity, USDX for stablecoin liquidity, and PIF for oracle data — all building towards an institutional-grade stack that pairs with Midnight's privacy layer.Key Takeaways:- Banks need privacy, compliance tooling, and execution predictability — not just speed.- Ethereum and Solana are public by default, which creates liability for institutions handling sensitive transactions.- MEV (maximal extractable value) is a hidden cost on public chains that lets bots front-run large trades.- Midnight offers programmable privacy using zero-knowledge proofs — private where needed, provable where required.- Selective disclosure lets institutions prove compliance to regulators without exposing business strategy to the market.- Midnight's mainnet launches end of March 2026, with Monument Bank and Google already involved.- Cardano's broader ecosystem — Leios, Layer 0, USDX, Pyth— complements Midnight to form a full institutional stack.- The real question isn't which chain is fastest, but which chain meets actual regulatory and operational requirements.Website: https://learncardano.ioX/Twitter: https://x.com/LearnCardanoDisclaimer: This content is for educational purposes only. Nothing constitutes financial advice.DISCLAIMER: This content is for informational and educational purposes only and is not financial, investment, or legal advice. I am not affiliated with, nor compensated by, the project discussed—no tokens, payments, or incentives received. I do not hold a stake in the project, including private or future allocations. All views are my own, based on public information. Always do your own research and consult a licensed advisor before investing. Crypto investments carry high risk, and past performance is no guarantee of future results. I am not responsible for any decisions you make based on this content.

Anticoagular o paciente com doença renal crônica (DRC) NUNCA foi um assunto fácil de desembolar… É preciso entender em que estágio ele está, se essa função é estável ou não, qual o risco hemorrágico envolvido e se a indicação de anticoagulação realmente se sustenta. Como, quando e para quem?No episódio #217 do DozeCast, Victor Bemfica e Diandro Mota recebem a Dra. Idelzuita Liporace (doutora pela USP e médica assistente do setor de anticoagulação do Instituto Dante Pazzanese) para uma conversa prática e sem simplificações sobre anticoagulação no paciente com doença renal crônica, com destaque para a avançada.

Chad Masterson & Charlie Plainview are the co-founders of OPNET: a protocol that brings smart contracts, DeFi & stablecoins to Bitcoin's base layer. No tokens, wrappers, or bridges are required. But how does it really work & how is it different from Omni, Counterparty, and Citrea? Time stamps: Time stamps: 00:00:36 Introducing Danny and Chad from OPNET 00:01:37 Defining OP NET and Consensus Protocols 00:03:19 Comparison to Counterparty and EVM Compatibility 00:05:39 Technical Implementation: Witness Field and Bitcoin Compliance 00:07:32 Leveraging Bitcoin's Native Scripting 00:09:03 Problems with Meta Protocols and Off-Chain Indexers 00:12:48 Potential for DeFi and Institutional Use 00:14:07 Layer Two Limitations and Liquidity Issues 00:15:35 Scaling and High Fee Environment 00:20:52 Stablecoins and OP 20 Token Standard 00:23:18 Freedom, Use Cases, and Bitcoin's Limitations 00:27:36 Critique of Liquid and Bridging Solutions 00:31:38 Lightning Network, Taproot Assets, and Payments Use Case 00:34:49 Bitcoin Yield, Loans, and Productive Capital 00:37:44 Criticism from Bitcoin Maximalists: Spam and Competing Tokens 00:42:06 Spam, UTXO Bloat, and Account-Based Model 00:44:51 Miner Incentives, MEV, and Transaction Ordering 00:50:04 Sponsor Plugs and Giveaway 01:04:52 OP NET's Target Audience and User Adoption 01:13:00 Bitcoin's Role: Peer-to-Peer Cash or Financial Layer? 01:23:00 Permissionless Innovation and Resilience 01:26:39 Emergent Use Cases and Historical Parallels 01:30:16 Airdrops, Incentives, and Early User Rewards 01:32:33 Security and Comparison Between OP-20 and BRC-20 01:34:18 Live DeFi Applications and Fee Experience 01:36:53 AI Coding FUD and Development Process 01:39:51 Decentralization, Node Operation, and Team Size 01:42:26 Final Questions: Criticisms, Wallets, and How to Try OP NET 01:45:37 Outro and Thanks

Semaglutida. Tirzepatida. Ozempic. Wegovy. Mounjaro. Raramente uma classe de medicamentos entrou tão rápido na prática clínica, e gerou tanta dúvida no consultório.Neste episódio do DozeCast, Mateus Prata e Raphael Rossi recebem o Dr. Eduardo Nakamura, endocrinologista e fundado do @endodirect, para um papo sobre as terapias baseadas em GLP-1: o que a ciência já provou, onde ainda tem lacuna, e como prescrever, ajustar e acompanhar esses pacientes na prática.

Every Bitcoin transaction needs to be verified on the blockchain. There is no central authority that does this, but Bitcoin's blockchain has run uninterrupted since 2009 and now carries a market capitalisation of $1.3 trillion, roughly 4% of US GDP. Its original promise was more radical: that we do not need a trusted intermediary to spend money, write contracts, or create finance. In the fifth LTI report, published today, Yackolley Amoussou-Guenou, Bruno Biais, and Sara Tucci-Piergiovanni ask how much of that promise has held. Bruno talks to Tim Phillips about blockchain's potential, its flaws, and its future.  It is a Nash equilibrium: if you believe others will follow the rules, it is in your interest to follow them too. On that foundation Bitcoin's ledger has been running continuously for 16 years. Smart contracts, pioneered by Vitalik Buterin's Ethereum, extend the logic to financial agreements. Decentralised finance promised to cut out rent-seeking intermediaries. Cryptocurrencies can step in where banks are broken or currencies have collapsed; in Lebanon, when bank accounts were frozen and payments stopped, businesses switched to crypto and kept operating. But the technology's libertarian origins may need to be sacrificed: As Bruno says, without transparency there is no trust, and transparency in this market may require regulation.The research behind this episode:Amoussou-Guenou, Yackolley, Bruno Biais, and Sara Tucci-Piergiovanni. 2026. "Can Blockchain Decentralize Money, Contracts, and Finance?" LTI Report 5. CEPR and Long-Term Investors@UniTo. Freely available to download at cepr.org. To cite this episode:Phillips, Tim, and Bruno Biais. 2025. "Can Blockchain Decentralize Money, Contracts, and Finance?" VoxTalks Economics (podcast). Assign this as extra listening. The citation above is formatted and ready for a reading list or VLE.About the guestBruno Biais is Professor of Finance at HEC Paris and a Research Fellow at the Centre for Economic Policy Research (CEPR). His research spanning financial market microstructure, corporate finance, and the economics of blockchain has made him one of the leading economists working at the intersection of finance and decentralised technology. He has studied blockchain and cryptocurrency markets since their early years, and his theoretical models of consensus mechanisms and cryptocurrency valuation have shaped how economists understand the conditions under which decentralised systems can and cannot sustain themselves.Research cited in this episodeThe blockchain is a distributed ledger maintained by a network of nodes, each holding an identical copy of the record of ownership. When a transaction is submitted, all nodes verify it against the existing ledger and update their copies to reach consensus on the new state. No central authority manages this process; its stability rests entirely on the incentive structure built into the protocol.Nash equilibrium is a concept from game theory, named for the mathematician John Nash, describing a situation in which each participant's strategy is the best response to the strategies of all others; no individual has an incentive to deviate unilaterally. Biais and co-authors identify the Bitcoin protocol as a Nash equilibrium: if you believe others will follow the rules, it is in your own interest to follow them too. That self-reinforcing alignment of incentives, rather than goodwill or central enforcement, is why the blockchain has remained valid since 2009.Smart contracts are lines of code deposited on a blockchain that execute automatically when specified conditions are met: if X, then Y. Vitalik Buterin introduced them through the Ethereum platform, which offers a richer programming language than Bitcoin and allows users to hold collateral on-chain to guarantee the contract will pay out. Smart contracts underpin automated market makers, decentralised lending, and a wide range of financial applications that require no counterparty or intermediary to enforce the agreement.Oracles are third-party services that transmit data about real-world events to a blockchain, allowing smart contracts to respond to things that happen off-chain. A contract that pays out when a house burns, for example, requires an oracle to report that event to the network. Oracles introduce a point of fragility: the authenticity and accuracy of off-chain information must be established before the network accepts it, and that verification is more vulnerable to error and manipulation than the on-chain consensus mechanism itself.Front-running and miner extractable value (MEV) describe the practice by which technically sophisticated actors exploit the public visibility of pending transactions to extract profits at the expense of ordinary users. Because transactions on public blockchains are broadcast to all nodes before they are confirmed, an actor who sees a large pending purchase can execute the same trade first, drive the price up, and then sell at a profit once the original transaction goes through. The cost falls on the smaller trader. Biais notes that the barriers to entry and economies of scale in this activity have concentrated power in the hands of a small, technically skilled group, recreating the kind of intermediary rents that decentralised finance was designed to eliminate.Automated market makers are smart contracts that provide continuous liquidity for trading between two assets by holding reserves of both in a pool and setting prices according to the ratio of the reserves. A large purchase of one asset depletes that side of the pool and raises its price; a large sale depresses it. Automated market makers have become a central mechanism of decentralised finance, replacing the order-book systems used in traditional exchanges.Stablecoins are cryptocurrency tokens designed to maintain a fixed value relative to a conventional currency, typically the US dollar. They are issued by private entities that hold reserves intended to back the peg. Tether, the largest stablecoin by market capitalisation, holds its reserves in a mix of Treasury bills, Bitcoin, and precious metals; in 2021, the US Commodity Futures Trading Commission fined Tether for misrepresenting those reserves and required it to disclose their composition, making this information publicly available for the first time. Dai is an algorithmically managed stablecoin that maintains its peg through over-collateralisation in cryptocurrency rather than conventional reserves.The Diamond-Dybvig model is a theoretical framework developed by Douglas Diamond and Philip Dybvig explaining why financial intermediaries that hold illiquid assets while issuing liquid claims are inherently vulnerable to runs. When enough depositors demand withdrawal simultaneously, the institution is forced to sell assets at a loss, making further withdrawals impossible and confirming the fears that triggered the run. Biais applies this logic to stablecoins: if enough holders attempt to redeem simultaneously, the issuer must sell its reserves in volume, driving down their price and potentially breaking the peg.Central bank digital currencies (CBDCs) are digital tokens issued and managed by central banks, distinct from both commercial bank deposits and private stablecoins. Biais distinguishes two potential use cases: retail CBDCs, which would allow individuals to hold central bank money directly, and wholesale CBDCs, which would facilitate settlement between large financial institutions. He regards the wholesale application as the more promising; a wholesale CBDC could enable fast, low-cost atomic settlement of cross-currency transactions between banks under central bank oversight, a significant improvement on current interbank settlement systems.MiCA (Markets in Crypto-Assets Regulation) is the European Union's regulatory framework for crypto-asset service providers, which came fully into force in December 2024. It requires licensing for issuers and service providers operating within the EU and imposes disclosure, reserve, and conduct requirements intended to align the sector more closely with the standards applied in traditional financial markets.Hayek's currency competition refers to the argument by Friedrich Hayek that competition between privately issued currencies would discipline monetary policy: users would switch away from currencies managed irresponsibly, and that threat would encourage better central bank behaviour. Biais applies this argument to cryptocurrencies and stablecoins in countries where the domestic currency has been mismanaged. He cites Nigeria, where sharp depreciation of the naira was accompanied by rising crypto adoption; over the following period, Nigeria's central bank raised interest rates and created a more transparent foreign exchange market. Biais suggests, tentatively, that the competitive pressure from crypto alternatives may have contributed to that improvement.More VoxTalks EconomicsDo stablecoins threaten financial stability? Stablecoins are digital tokens, pegged to a fiat currency. What could possibly go wrong? For one type of stablecoin the answer is: plenty, according to Richard Portes. In coin we trust Crypto investors make a lot of noise, but who are they, and do they behave differently to other retail investors?Do cryptocurrencies matter? Can cryptocurrencies be useful? Not just for crypto bro speculators, but as a shield against the depreciation of the official currency if a government is determined to pursue inflationary policies.

The Daily Gwei Refuel gives you a recap every other week day on everything that happened in the Ethereum and crypto ecosystems - hosted by Anthony Sassano. Timestamps and links to topics discussed: https://daily-gwei-links.vercel.app/recent 00:00 Introductory song 00:10 The EF mandate https://x.com/ethereumfndn/status/2032460726728573298 https://x.com/barnabemonnot/status/2033089581810077821 23:06 Etherealize on layer 2's https://x.com/Etherealize_io/status/2032091862513684661 28:20 New MaxEB dashboard https://x.com/trent_vanepps/status/2031480995392655689 29:24 $50mil MEV swap https://x.com/bh359/status/2032195231681241218 38:15 Encrypted mempools https://x.com/_julianma/status/2032067843635007508 42:53 BlackRock's staked ETH ETF is now live https://x.com/JSeyff/status/2032204440082460707 This episode is also available on YouTube: https://youtu.be/kJlfuYXewLs Subscribe to the newsletter: https://thedailygwei.substack.com/ Subscribe on YouTube: https://www.youtube.com/channel/UCvCp6vKY5jDr87htKH6hgDA/ Follow Anthony on Twitter: https://twitter.com/sassal0x Follow The Daily Gwei on Twitter: https://twitter.com/thedailygwei Join the Discord Channel: https://discord.gg/4pfUJsENcg DISCLAIMER: All information presented across all of The Daily Gwei's communication channels is strictly for educational purposes and should not be taken as investment advice.

In this episode, I sit down with Shresth Agrawal, co-founder of Pod Network, to unpack why the world needs yet another Layer 1.We go deep into MEV, front-running, and why today's blockchain markets are still unfair. Shresth explains how Pod is building a purpose-built L1 designed for high-performance, MEV-free markets. We break down how auctions replace traditional transaction ordering, how Pod can process 300,000 orders per second, and why sub-second settlement changes everything.We also talk about product-market fit in Web3. Are payments and markets the only real use cases? What can founders learn from Ethereum, Hyperliquid, and newer L1s? And what's Pod's go-to-market plan?If you care about fair markets, decentralized finance, or the future of on-chain trading, this episode is for you.

This conversation covers the latest developments in the crypto space, focusing on the Cardano ecosystem, particularly the launch of USDC, liquidity improvements, and the innovative Midnight Network. It discusses the importance of user experience in crypto transactions, the emergence of projects on Midnight, and the challenges posed by Maximal Extractable Value (MEV) bots. Additionally, it highlights partnerships and the future of Cardano, including hardware preparations for becoming a Midnight validator.TakeawaysThe Korean government accidentally compromised a seed phrase.USDC is now available on the Cardano ecosystem, enhancing liquidity.Cross-chain capabilities are improving for Cardano.User experience for USDC transactions needs enhancement.Midnight Network focuses on privacy and selective disclosure.Several projects are already building on Midnight.MEV bots pose a significant risk to users in crypto transactions.Partnerships like Pair Point are crucial for Midnight's success.The Cardano Foundation is expanding its educational resources through Binance Academy.Hardware is essential for becoming a Midnight validator.Chapters00:00 Intro02:51 USDC on Cardano14:13 Pyth is next!15:44 Midnight City17:42 Projects Building on Midnight21:16 Privacy prevents MEV attacks23:41 Midnight and Pairpoint25:07 Cardano Foundation Institutional Adoption Track26:09 Cardano Scaling is Coming29:08 Cardano on Binance Academy29:54 Strike is Killing it30:58 Mithril Signers32:11 Midnight Node Incoming36:18 SupportDISCLAIMER: This content is for informational and educational purposes only and is not financial, investment, or legal advice. I am not affiliated with, nor compensated by, the project discussed—no tokens, payments, or incentives received. I do not hold a stake in the project, including private or future allocations. All views are my own, based on public information. Always do your own research and consult a licensed advisor before investing. Crypto investments carry high risk, and past performance is no guarantee of future results. I am not responsible for any decisions you make based on this content.

Gm! In this episode we discuss Blockworks' new Solana-focused Lightspeed IR platform and a report on Solana block building. We examine the rivalry between Jito BAM and Harmonic, impacts on transaction ordering, fees, market structure, validator clients, and the push toward protocol-level solutions like MCP and application-controlled execution.Enjoy! -- Follow Lightspeed: ⁠https://twitter.com/Lightspeedpodhq⁠ Follow Sam: https://x.com/minnus Follow Carlos: https://x.com/0xcarlosg Follow Danny: https://x.com/defi_kay_ Join the Lightspeed Telegram: ⁠https://t.me/+QHlbNTNS4gc1ZTVh -- Join us at DAS (Digital Asset Summit) in New York City this March!  Use the link below to learn more, and use code LIGHTSPEED200  to get $200 off your ticket! See you there! Learn more + get your ticket here: https://blockworks.co/event/digital-asset-summit-nyc-2026 -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- Timestamps: (0:00) Introduction (3:42) Lightspeed IR Platform Launch (6:40) Block Building on Solana (12:28) Jito Bam vs. Harmonic: Architecture Breakdown (16:51) MEV, Fees, and Market Structure Impacts (34:04) MCP and Solana's Path Forward (48:49) What Happened to Jito and Harmonic? (55:55) Alpenglow & MCP Timeline (59:03) Closing Comments -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Danny, and our guests may hold positions in the companies, funds, or projects discussed.

MegaETH mainnet is live, kicking off a new frontier for Ethereum scaling: ultra-low latency, massive throughput, and an execution environment built to unlock apps that can't exist on L1. Lei Yang & Namik break down why Vitalik's latest L2 framing validates “barbell” scaling, what users actually inherit from Ethereum (censorship resistance, exit guarantees, and fraud-proof security assumptions), and why stages + governance are harder than they look.  Plus: the mainnet stress test (11.4B tx in 7 days, 55k peak TPS), the economics shift toward stablecoin yield with USDM, proximity markets for MEV, and MegaETH's aggressive app-incubation strategy. ------

In this episode, host Friederike Ernst is joined by Thomas Thiery, a researcher at the Ethereum Foundation, to discuss EIP-7805 and the implementation of FOCIL (Fork-Choice Enforced Inclusion Lists). Thomas explains how the rise of MEV (Maximal Extractable Value) has created a centralized builder market where a few actors now control over 85% of Ethereum's block production, creating a dangerous bottleneck for censorship. FOCIL addresses this by empowering a decentralized committee of 16 validators to mandate transaction inclusion, making any block that ignores these lists invalid. They explore the "Tornado Cash" moment and the risks of "silent censorship" for competitive or regulatory reasons. Thomas explains why FOCIL intentionally prioritizes the public mempool over MEV-heavy transactions to prevent the system from being co-opted. Finally, the conversation looks at the future of the Ethereum roadmap, including the Osaka fork and the technical trade-offs between inclusion lists and long-term privacy solutions like encrypted mempools. Topics00:00 Intro & FOCIL04:15 MEV & Centralization09:30 The Builder-Searcher Pipeline15:00 Silent Censorship Risks21:45 FOCIL Architecture & Committees27:10 Validity Rules for Attestors35:20 Spam Protection & Invalid TXs42:15 FOCIL vs. Encrypted Mempools49:00 EIP-7805 Status & Fork Timelines55:30 Future: PQC & ZK EVMLinksThomas Thiery on X: https://x.com/soispoke Ethereum Foundation: https://ethereum.foundation/ EIP-7805 (FOCIL): https://eips.ethereum.org/EIPS/eip-7805 Gnosis: https://gnosis.io/Sponsors: Gnosis: Gnosis has been building core decentralized infrastructure for the Ethereum ecosystem since 2015. With the launch of Gnosis Pay last year, we introduced the world's first Decentralized Payment Network. Start leveraging its power today at http://gnosis.io

In this episode of FYI – For Your Innovation, ARK's Cathie Wood speaks with Don Wilson, a pioneer in crypto market infrastructure and the founder of DRW and Cumberland. They discuss the accelerating shift of traditional finance onto blockchains, focusing on the emergence of the Canton Network, a public permissionless blockchain designed for institutions—with privacy and permissioning at its core. Don unpacks why Depository Trust and Clearing Corporation's (DTCC's) decision to tokenize U.S. Treasuries on Canton marks a turning point in institutional adoption, how Canton balances decentralization with control, and what makes it uniquely suited for real-world asset (RWA) tokenization. The conversation covers stablecoins, the evolving role of private credit and equity, and how tokenization might reshape collateral, leverage, and capital efficiency. Don also offers sharp takes on Maximal Extractable Value (MEV) vs. payment for order flow, prediction markets, and whether we're still in a “four-year crypto cycle.” A must-listen for those tracking the future of digital asset infrastructure.Key Points From This Episode:[00:00] Intro + Why tokenization matters: reducing costs, unlocking capital efficiency, and ARK's thesis on blockchain infrastructure[06:27] Don Wilson's background, early crypto involvement, and the founding of Cumberland and Canton[09:57] Why privacy and permissioning are essential for institutional blockchains[13:44] DTCC's adoption of the Canton Network and the mechanics of tokenizing U.S. Treasuries[25:05] Real-world benefits of tokenization: collateral mobility, after-hours lending, and stablecoin settlement[29:23] Prediction markets: institutional vs. retail use cases and the importance of privacy on-chain[35:13 – 37:23] Scaling Canton: new strategic investors and trillions in tokenized assets already on-chain[37:25 – 47:34] Private equity and credit on-chain: implications for efficiency, leverage, and retail access[47:34] MEV vs. payment for order flow: why Don believes MEV resembles illegal front-running[48:18] Crypto market structure: October flash crash, ETFs, and institutional buyers in the current cycle[55:10] Closing remarks

Welcome to The Chopping Block — where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. This week, the crew dives into the shift from airdrops to ICOs as Monad, MegaETH, and Coinbase's new sale format spark a rethink of how tokens should be distributed. They discuss ICO Beast's hedging fiasco, why most airdrops fail to create real users, and whether fixed-price ICOs are a better path for long-term alignment. The gang also unpacks Uniswap's major “unification,” the end of Labs vs. Foundation, and UNI finally becoming the protocol's value-accrual asset. In the back half, they touch on the “low carb crusader” MEV trial, the hung jury, and the broader question of whether MEV games belong in criminal court at all. A concise, high-signal look at where tokenomics, distribution, and crypto's legal boundaries are heading next. Show highlights

“‘The battle belongs to the Lord” (1 Samuel 17:47 MEV). When everyone stared at Goliath, David never gave him the...