Podcasts about mev

Você otimizou o LDL. Chegou na meta de ApoB. E o paciente volta meses depois com um novo evento. Neste episódio especial, com apoio da Novo Nordisk, Diandro Mota e William Batah recebem o Dr. Eduardo Lima, doutor em Cardiologia pela USP, professor colaborador e supervisor da Residência em Cardiologia da FMUSP/InCor e Head Nacional de Cardiologia da Rede Américas, para uma conversa que pode redefinir como você enxerga o risco residual. A tese é direta: a aterosclerose nunca foi só uma doença de colesterol. Ela é imunometabólica, e a inflamação subclínica pode ser o elo que faltava.O que você vai aprender:

Durante anos, o cardiologista que atendia um paciente com ICFEp tinha poucas ferramentas: diurético para o sintoma e tratamento das comorbidades. Enquanto a ICFEr ganhou o Quarteto Fantástico com redução de 64% em mortalidade e hospitalização, a ICFEp acumulava estudo negativo atrás de estudo negativo. CHARM-Preserved, I-PRESERVE, PEP-CHF, TOPCAT ficaram no “quase”, mas não atingiram ápice no quesito robustez de evidência para beneficios.No Ep. 227 do DozeCast, os hosts Plínio Wolf e Victor Bemfica convidaram a Dr. Mariane Higa (chefe do setor de ICFEp do Dante Pazzanese) para abrilhantar a mesa de especialistas em insuficiência cardíaca que convivem com os dilemas da ICFEp todos os dias: da epidemiologia e fisiopatologia à fronteira terapêutica atual.O que você vai aprender:

Seu paciente chega no consultório com um vidro de ômega-3 importado e te olha esperando confirmação: "é bom pro coração, né, doutor?" Durante décadas, a resposta foi automática. Hoje, ela precisa de mais cuidado, e de evidência.Nesse episódio, Mateus Prata e Raphael Rossi mergulham de cabeça na história do ômega-3 e risco cardiovascular: da expedição dos anos 1970 à Groenlândia até o PISCES, publicado no NEJM em 2025. Um episódio que vai te fazer repensar o que você diz (e prescreve) no consultório.O que você vai aprender:

A coronariografia veio normal. Mas o paciente continua com dor, teste isquêmico positivo e qualidade de vida no chão. O que você está deixando de investigar?Neste episódio, Mateus Prata e Raphael Rossi mergulham na fisiologia invasiva da microcirculação coronariana — o território que a angiografia simplesmente não enxerga. Falamos sobre INOCA, ANOCA, disfunção microvascular e espasmo coronariano: por que esses diagnósticos ainda escapam e como o teste fisiológico invasivo pode mudar o rumo clínico de forma concreta.

In this episode, I sat down with functional practitioner and Mountain Metabolic Coach Mehvish Khan to talk about the deeper connection between hormones, gut health, stress, metabolism, and fat loss. We break down what actually matters for women's health, why symptoms shouldn't be ignored, and practical ways to support your body without falling into extremes.Connect with Mev on Instagram @coach_mev Mountain Metabolic Coaching [Application Link] — Fat loss, body recomposition, nutrition, hormones, performance, all with full 1:1 coach support. Fit For Hiking Guides  — Workouts to get you trail-ready.More Resources — Wellness tips, hiking + travel guides, and blogs.Shop My Favorite Gear — Amazon storefrontFit For Hiking Instagram Bradee Instagram 

Dr. Lorenzo Tomé conversa com Bruno Colantoni, cardiologista e presidente do Colégio Brasileiro de Medicina de Estilo de Vida (CBMEV), sobre uma das transições mais importantes da medicina contemporânea: sair do modelo de tratar doenças para construir saúde de fato, e o que isso significa para a carreira e o consultório do médico. O episódio parte de um dado que não dá pra ignorar: 75% das mortes no Brasil e no mundo vêm de doenças crônicas não transmissíveis, e o modelo de consulta avulsa não foi feito para tratar esse perfil de paciente. A conversa passa pela origem da especialidade nos Estados Unidos, pelos seis pilares da MEV, pela ciência da mudança de comportamento e pelo processo completo de certificação internacional. Mas também vai além disso trazendo a discussão sobre por que o paciente paga caro pela caneta emagrecedora e não paga pela consulta, o que isso revela sobre percepção de valor, e como o médico pode reposicionar a sua entrega dentro de um mercado de wellness que movimenta R$ 100 bilhões por ano no Brasil. Se você já sabe que precisa entregar mais ao paciente, mas ainda não encontrou a estrutura clínica e de negócio para fazer isso, esse episódio aponta o caminho. O background do Bruno Colantoni Bruno Colantoni é médico cardiologista formado pela Faculdade de Medicina de Marília, com residência em Clínica Médica, Cardiologia e Ecocardiografia pela Unicamp. Construiu carreira como cardiologista clínico, sócio de clínica própria, e ao longo do processo viveu na pele a transformação que hoje ensina: partiu de um quadro de obesidade, sedentarismo e triglicérides de 700 mg/dL para emagrecer 30 kg e descobrir, a partir da própria experiência, o impacto real dos hábitos de vida nos desfechos clínicos. Em 2018, participou de um curso de Lifestyle Medicine em Harvard, onde teve contato com os fundadores do Colégio Brasileiro de Medicina de Estilo de Vida. Desde então, dedica sua carreira à difusão e consolidação da MEV no Brasil, hoje como presidente do CBMEV e parceiro estratégico da SD Escola na capacitação dos médicos em medicina de estilo de vida. Entre na Comunidade SD no WhatsApp e tenha conteúdo gratuito todos os dias sobre negócios médicos. Acesse Assista esse episódio também em vídeo no Youtube no nosso canal Saúde Digital Podcast! Acesse os episódios anteriores! SD358 - Upsell ético no consultório: mercado de wellness sem "empurroterapia" SD357 - As consultas avulsas estão falindo SD356 - O que ninguém lhe ensinou sobre sucessão na medicina Musica: Declan DP - Climb Music © Copyright Declan DP 2018 - Present. https://license.declandp.info | License ID: DDP1590665  

A síncope vasovagal sempre foi um dos maiores desafios da cardiologia clínica e da eletrofisiologia.Mas será que estamos entrando em uma nova era no tratamento desses pacientes?Neste episódio do DozeCast, recebemos o Dr. Juan Zerpa — presidente da LAHRS, eletrofisiologista pela SOBRAC e uma das maiores referências em cardioneuroablação na América Latina — para discutir uma técnica que vem transformando o manejo de pacientes com síncope vasovagal cardioinibitória e bradiarritmias funcionais.Falamos sobre fisiopatologia, seleção de pacientes, técnica do procedimento, evidências atuais, limitações e o grande debate: a cardioneuroablação pode evitar um marca-passo em pacientes selecionados?O que você vai aprender:

幻冬舎の暗号資産（仮想通貨）/ブロックチェーンなどWeb3領域の専門メディア「あたらしい経済 https://www.neweconomy.jp/ 」がおくる、Podcast番組です。 ーーーーー 【番組スポンサー】 この番組は、暗号資産取引におけるフルラインナップサービスを提供する「SBI VCトレード」のスポンサーでお届けします。 ーーーーー SBI VCトレードは、「暗号資産もSBI」のスローガンのもと、国内最大級のインターネット総合金融グループであるSBIグループの総合力を生かし、暗号資産取引におけるフルラインナップサービスを提供しております。暗号資産交換業者・第一種金融商品取引業者・電子決済手段等取引業者として高いセキュリティ体制のもと、暗号資産の売買にとどまらない暗号資産運用サービスや法人向けサービスの展開、さらにステーブルコインのユーエスディーシー（USDC）を国内で初めて取り扱っております。 ーーーーー SBI VCトレード公式サイト：https://account.sbivc.co.jp/signup?hc_ak=1RNML.3.M06AS ーーーーー 【紹介したニュース】 ・日本ブロックチェーン基盤、信託型の円ステーブルコイン「EJPY」発行へ ・インタートレードら、国産HWウォレットとFireblocks統合の資産管理基盤を商用化へ ・米上院、暗号資産市場構造法案「CLARITY法」修正版公開。14日に委員会採決へ ・イーサリアム財団、「ブラインド署名」対策で新標準。昨年のバイビットハックなど背景に ・アプトスラボ、MEV対策で「暗号化メモリプール」提案。イーサリアムでも研究が進む領域 ・スタークネット、プライバシー対応ビットコイン「strkBTC」公開。シールド送金に対応 ・米国初、「ハイパーリキッド（HYPE）」現物ETFがナスダック上場、21シェアーズ組成 ・クラーケン親会社ペイワードとフランクリン・テンプルトン提携、トークン化運用商品をオンチェーン展開へ ・ムーンペイ、AI・金融市場系研究のドーンラボ買収、AI取引ツール提供開始 ・MARA、15億ドル規模のビットコイン売却。AIデータセンターへ本格転換 ・サークル、独自L1「Arc」のトークンで約3.2億ドル調達。a16zやブラックロックら参加 ・クリプトドットコム、UAEで非現金型決済サービスの「SVFライセンス」取得 【あたらしい経済関連リンク】 ニュースの詳細や、アーカイブやその他の記事はこちらから https://www.neweconomy.jp/

Por décadas, o café entrou no consultório como suspeito. Arritmogênico, hipertensor, possível gatilho de morte súbita. Em 2025, um ensaio randomizado publicado na JAMA virou essa narrativa de cabeça para baixo, e os dados são mais fortes do que você imagina.Neste episódio, o DozeCast convida o Dr. Bruno Mioto, cardiologista com doutorado em café e saúde cardiovascular, e Matheus Dominguito, um dos grandes produtores de café no Brasil, para uma conversa que mistura evidência clínica de alto nível com a arte de fazer uma boa xícara. Foram poucas as vezes em que a cardiologia e a cultura do café se encontraram tão bem.O que você vai aprender:

On the ground at Solana Accelerate Miami 2026, we interviewed builders and innovators shaping the future of Web3.Guest: Lucas Bruder Co-Founder & CEO of Jito LabsJTX Waitlist ➜ https://bit.ly/JTXtrade00:00 intro00:08 Jito Labs00:16 JTX Announcement01:02 Moving away from Infrastructure02:24 JTX vs Jupiter Exchange03:25 Lending & Borrowing04:10 Not a DEX04:45 Solana Focus05:33 Upgrading Jito & Solana For Traders08:08 Pro-Traders vs Retail Adoption09:22 Prediction Markets on Solana10:22 MEV on Solana11:56 outro#Crypto #solana #Ethereum~Solana's New CEX Killer?

In this episode, host Friederike Ernst is joined by Kubi Mensah, CEO and co-founder of Gattaca, the company behind Titan Builder. Kubi sheds light on the highly competitive and often opaque world of Ethereum block building, explaining how Gattaca evolved from a centralized exchange proprietary trading firm to one of the three dominant builders responsible for constructing the vast majority of Ethereum blocks today .  They dissect the true "journey of a transaction," revealing why over half of all Ethereum transaction value bypasses the public mempool in favor of private order flow auctions and MEV-protection services . Kubi explains the intricate mechanics of top-of-block bidding by high-frequency DeFi arbitrageurs, the necessity of extreme latency optimization, and the "flywheel effect" that makes block building a natural oligopoly . Finally, the discussion turns to the future of the Ethereum roadmap, unpacking how upcoming upgrades like ePBS (enshrined Proposer-Builder Separation) and FOCIL (Fork-Choice Enforced Inclusion Lists) aim to permanently alter the power dynamics between block builders, validators, and originators .  Topics04:15 Transitioning from TradFi Trading to Ethereum Block Building09:30 Redefining the Builder: Relays and Order Flow Auctions15:00 Unpacking the Mempool: Public vs. Private Transactions21:45 The Anatomy of a Block & "Top-of-Block" Arbitrage27:10 How Builders Pay Proposers to Win Auctions35:20 The Oligopoly: Why Only 3 Builders Dominate Ethereum42:15 Trust in the Dark Forest: Handling Searcher Bundles49:00 The Convergence of Builders and Solvers55:30 The Impact of ePBS, FOCIL, and Pre-confirmationsSponsors: Lido V3 introduces stVaults: a modular staking infrastructure that lets builders and institutions deploy custom staking vaults, while staying anchored to stETH as a shared liquidity layer.Get started building with Lido V3 today: https://lido.fi/stvaults?mtm_campaign=epicenterBlock Space Forum: https://blockspace.forum/

Os 10 ensaios clínicos do ACC.26 que você precisa conhecer – discutidos por quem entende.Neste episódio especial do DozeCast, William, Rapha e Plínio se reúnem para destrinchar os principais Late-Breaking Trials apresentados no American College of Cardiology 2026 – o congresso que pautará a cardiologia mundial nos próximos meses.Da revascularização de oclusões crônicas (ORBITA-CTO) à decisão entre TAVI e angioplastia ( PRO-TAVI), passando pela prevenção cardiovascular (VESALIUS), insuficiência cardíaca (SPIRIT-HF, DIG- RHD),  oclusão do apêndice atrial (CHAMPION), tromboembolismo pulmonar de alto risco (HI-PEITHO) e muito mais! Cada estudo é analisado com olhar clínico, crítico e aplicável ao dia a dia.Se você quer sair do episódio sabendo o que mudou, o que confirmou e o que ainda gera dúvida após o ACC.26, esse é o conteúdo definitivo.

After 15 years of being a Bitcoin-only maximalist and about a decade of promoting BIP300 as a soft fork, LayerTwo Labs CEO Paul Sztorc decided to launch Ecash: a hard fork of Bitcoin in which every BTC holder gets free coins. There's a catch, though: while everyone can claim 1 ecash for every bitcoin that they own, Satoshi can only claim half. Meaning that a returning Satoshi will only be able to claim half his coins, while the other half (550k) is currently being sold to investors in order to fund the development and bootstrapping of Ecash. What's more controversial: the hard fork or the SHAD (Satoshi Half Air Drop)? Only time will tell. But the Ecash hard fork is scheduled to happen in August 2026... unless Bitcoin activates BIP300 in the meantime. Game theory at its finest! Time stamps: 00:00:58 – Paul Sztorc announces the new Bitcoin hard fork project, eCash, sharing his motivation for launching it and setting the stage for the discussion. 00:03:02 – eCash's technical details are explained, including its smaller 400kB block size and the integration of drivechains (BIP 300) to enhance scalability and flexibility. 00:04:55 – The initial drivechains launching with eCash are described, such as Thunder for scalability, ZSide for privacy, and additional chains like CoinShift, BitNames, and Photon. 00:09:28 – Security aspects of sidechains are discussed, covering the 256 sidechain limit, potential outcomes if sidechains fail, and the risks users face when moving coins. 00:14:26 – The project's name, Ecash, is revealed, with a comparison to Bitcoin Cash and an explanation of the naming decision. 00:15:40 – Paul delves into the philosophy behind the hard fork, his views on Bitcoin maximalism, and his intention to remain committed to both Bitcoin and eCash. 00:20:35 – Mining dynamics are explored, including SHA256 mining competition, miner incentives, and the potential for MEV (miner extractable value) issues. 00:22:36 – Paul critiques the current state of Bitcoin, highlighting user and developer frustration, stagnation, low transaction fees, and gridlock in development. 00:29:40 – The potential for eCash to attract frustrated Bitcoin builders is considered, with references to similar migrations in crypto history. 00:31:38 – Ethereum's rise is analyzed as a consequence of Bitcoin's block size wars, with discussion on missed opportunities and lessons learned. 00:41:06 – The likelihood and impact of further Bitcoin hard forks are speculated upon, focusing on community fragmentation and effects on value. 00:41:49 – Hard forks are framed as healthy competition that benefits investors by providing free coins and stimulating innovation. 00:48:20 – The decision to reassign half of Satoshi's coins for development and community incentives is explained, addressing concerns about distribution. 00:54:07 – Quantum computing threats, Satoshi's mining behavior, and the rationale for the coin distribution are discussed in the context of long-term security. 01:36:00 – Users are advised to self-custody their Bitcoin to claim eCash, with an outline of the claiming process and best practices. 01:39:01 – Technical steps for claiming eCash using private keys are detailed, including wallet compatibility and the process for users. 01:43:26 – The potential for NFT and ordinal activity on eCash is addressed, along with how LayerTwo Labs will manage onboarding and network congestion. 01:45:35 – Drivechain security parameters are confirmed, with eCash using a 13,000-block security window in line with BIP 300's Bitcoin implementation. 01:52:06 – The transition from a centralized project launch to decentralized development and governance. 01:54:36 – The current developer team size (about nine members) is shared, along with incentives for external developers to contribute to eCash. 01:58:26 – eCash is compared to Bitcoin Cash, with discussion on network effects, competition, and the potential for eCash to drive improvements in Bitcoin. 02:07:22 – The session concludes with future plans, a call for community engagement, and the possibility of follow-up discussions as the project evolves.

Fibrilação atrial, palpitações, hipertensão sistólica isolada, bradicardia, derrame pericárdico, dislipidemia refratária, insuficiência cardíaca sem causa clara. Quantas vezes o problema pode estar na tireoide e o cardiologista deixa passar?Neste episódio do DozeCast, Victor Bemfica e Thaysa Lousada discutem a relação entre tireoide e coração em uma conversa prática, clínica e extremamente útil para quem atende pacientes no mundo real. A proposta do episódio é simples: mostrar por que a tireoide não pode ser tratada como detalhe laboratorial quando o sistema cardiovascular está em jogo.

In this episode, Austin chats with Rahul Jain (Head of Trading at Ellipsis Labs) to explore the evolution of market making in crypto. Rahul discusses what gives crypto market makers an edge, why being early matters, and how crypto has created new challenges around MEV, transaction landing, and execution. They explore the future prospects of prop AMMs, perps, MCP, and what it will take for on-chain finance to scale beyond crypto-native users and compete with traditional markets.    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Seu paciente tem LDL alto, risco cardiovascular elevado e não tolera estatina. O que você prescreve?Neste episódio do DozeCast, o Mateus Prata e a Raquel Rios fazem uma imersão completa no ácido bempedoico: da farmacologia molecular ao maior ensaio clínico já desenhado exclusivamente para intolerantes a estatinas. Se você ainda não incorporou essa droga na sua prática, esse é o episódio que vai mudar isso.O que você vai aprender nesse episódio:

I spoke to Luis Bezzenberger of Brainbot and core contributor to Shutter Network, about MEV and threshold encryption for encrypted mempools.Luis comes from a background in distributed systems and has spent years thinking about how cryptography can level the playing field between ordinary users and sophisticated actors who exploit the transparency of public mempools. We dig into how threshold encryption works, why encrypted mempools like what Shutter Network is building, could protect users from front-running without sacrificing decentralization, and what it actually takes to get something like this shipped at the protocol level. We also get into the broader architecture puzzle — encrypted mempools PBS, FOCIL, and why Luis thinks these three pieces together form the holy trinity for censorship resistance on Ethereum.This episode is sponsored by NYM, the world's most private VPN. Unlike traditional VPNs, Nym uses a decentralized mixnet to scramble your internet data — hiding who you're talking to, when, and how often. You can switch between full mixnet mode for maximum anonymity, or a faster VPN mode for everyday use.Use the code blockchainsocialist when signing up and get an extra month!If you liked the podcast be sure to give it a review on your preferred podcast platform. If you find content like this important consider donating to my Patreon starting at just $3 per month. It takes quite a lot of my time and resources so any amount helps. Follow me on Twitter (@TBSocialist) or Mastodon (@theblockchainsocialist@social.coop) and join the r/CryptoLeftists subreddit. Support the showICYMI I've written a book about, no surprise, blockchains through a left political framework! The title is Blockchain Radicals: How Capitalism Ruined Crypto and How to Fix It and is being published through Repeater Books, the publishing house started by Mark Fisher who's work influenced me a lot in my thinking. The book is officially published and you use this linktree to find where you can purchase the book based on your region / country.

Crypto News: Treasury Secretary Scott Bessent calls for the crypto market structure bill Clarity Act to be passed asap. Trump will attend meme coin event. XRP adjacent Flare proposes protocol-level MEV capture and 40% inflation cut.Brought to you by

Você já se deparou com um paciente com insuficiência cardíaca francamente descompensada, apesar de achados ecocardiográficos estruturais pouco exuberantes — fração de ejeção preservada, câmaras de dimensões normais e espessura ventricular sem alterações significativas? Pensou em pericardite constritiva? E, mais do que isso, sentiu segurança para interpretar achados como annulus reversus, septal bounce e septal shift?Neste episódio, vamos desvendar a pericardite constritiva: do diagnóstico clínico à interpretação da multimodalidade de imagem, sempre com base na compreensão da fisiopatologia da doença — elemento central para reconhecer seus achados e conduzir o caso de forma adequada. Também discutiremos o tratamento individualizado, seja ele clínico, invasivo ou combinado.Ao longo da conversa, mostraremos que, na pericardite constritiva, nada é absoluto: o pericárdio nem sempre está espessado, nem sempre está calcificado, e a constrição nem sempre é irreversível.Embora relativamente rara, a pericardite constritiva tem grande impacto prognóstico quando não é reconhecida e manejada corretamente. Isso é especialmente relevante porque a insuficiência cardíaca secundária à constrição pode, sim, ser reversível — desde que o diagnóstico e o tratamento sejam feitos no momento certo.O que você vai aprender neste episódio:

Don Wilson, founder and CEO of DRW, said Wall Street firms are unlikely to adopt fully transparent public blockchains. Canton continues is FUD against permissionless blockchains like Solana and Ethereum in order to gain traction on their new Citadel-backed network of incumbents.GUEST: Rebecca Rettig, CLO at Jito LabsFollow Rebecca on X ➜ https://x.com/RebeccaRettig1Liquid Stake on Jito ➜ https://www.jito.network/00:00 intro00:30 Canton not an institutional chain?01:10 Small Startups?01:35 Citadel backs Canton02:12 Don Wilson vs Solana and ETH02:55 So it is an institutional chain03:09 Rebecca Fires Back at Solana FUD03:41 Yuval insults Rebecca04:09 Canton twitter war drama04:53 Rebecca Rettig on MEV vs TradFi07:08 Paul vs Yuval on DTCC & Citadel 09:01 Reg-NMS Law enables opaque Wallstreet11:02 Crypto Kill Switch proposals12:49 Vibhu: Why Memecoins are important14:19 Drift Hack & Cybersecurity15:59 Lightning Round16:22 Robinhood Coincidence16:46 Canton desperate18:03 Jito vs Citadel18:42 Uniswap & Jito Auctions19:17 JitoSOL19:46 Canton not worth hacking20:21 More corpo chains coming21:44 CLARITY vs Solana22:15 outro#Crypto #Solana #Canton~Institutions & Retail Want Solana... not Canton

VO₂máx virou o queridinho da longevidade e performance. Mas o que a evidência realmente diz sobre ele?Nesse episódio do DozeCast, Mateus Prata, Fernanda Justo e Thaysa Louzada recebem o Dr. Silvio Póvoa para destrinchar, de ponta a ponta, o que o VO₂ pode (e o que ele não pode) dizer sobre o seu paciente. Um tema que saiu dos laboratórios de fisiologia, passou pelo consultório de cardiologia e chegou ao pulso de todo mundo via wearables. E que merece ser discutido com rigor.O que você vai aprender nesse episódio:

We break down the transaction pipeline from validators to builders, explore the risks of today's order flow systems, and unpack how encrypted mempools aim to reduce MEV, improve privacy, and strengthen censorship resistance. Featuring Luis Bezzenberger from Shutter Network and Julian Ma from the Ethereum Foundation's Robust Incentives Group, the conversation dives into EIP-8184 (LUCID), its design, tradeoffs, and what it means for the future of Ethereum market structure. If you care about MEV, decentralization, and the path to low-risk DeFi, this is a must-listen! Follow @bezzenberger and @_julianma on X

At the Digital Asset Summit 2026 in New York, a key question came up: what do banks actually need from blockchain? The answer isn't speed or hype — it's privacy, compliance, and protection from front-running. In this episode, Peter breaks down why public chains like Ethereum and Solana fall short for institutional use, and where Cardano and Midnight fit into the picture.The episode covers the three core requirements institutions have — selective disclosure, execution predictability, and compliance tooling — and explains why neither Ethereum nor Solana can deliver on all three natively. Peter walks through how MEV (maximal extractable value) creates a hidden tax on public chains, why that's a dealbreaker for banks moving serious capital, and how Midnight's programmable privacy using zero-knowledge proofs offers a fundamentally different approach.The broader Cardano ecosystem also gets a look-in: Leios for scaling, Layer 0 for cross-chain connectivity, USDX for stablecoin liquidity, and PIF for oracle data — all building towards an institutional-grade stack that pairs with Midnight's privacy layer.Key Takeaways:- Banks need privacy, compliance tooling, and execution predictability — not just speed.- Ethereum and Solana are public by default, which creates liability for institutions handling sensitive transactions.- MEV (maximal extractable value) is a hidden cost on public chains that lets bots front-run large trades.- Midnight offers programmable privacy using zero-knowledge proofs — private where needed, provable where required.- Selective disclosure lets institutions prove compliance to regulators without exposing business strategy to the market.- Midnight's mainnet launches end of March 2026, with Monument Bank and Google already involved.- Cardano's broader ecosystem — Leios, Layer 0, USDX, Pyth— complements Midnight to form a full institutional stack.- The real question isn't which chain is fastest, but which chain meets actual regulatory and operational requirements.Website: https://learncardano.ioX/Twitter: https://x.com/LearnCardanoDisclaimer: This content is for educational purposes only. Nothing constitutes financial advice.DISCLAIMER: This content is for informational and educational purposes only and is not financial, investment, or legal advice. I am not affiliated with, nor compensated by, the project discussed—no tokens, payments, or incentives received. I do not hold a stake in the project, including private or future allocations. All views are my own, based on public information. Always do your own research and consult a licensed advisor before investing. Crypto investments carry high risk, and past performance is no guarantee of future results. I am not responsible for any decisions you make based on this content.

Anticoagular o paciente com doença renal crônica (DRC) NUNCA foi um assunto fácil de desembolar… É preciso entender em que estágio ele está, se essa função é estável ou não, qual o risco hemorrágico envolvido e se a indicação de anticoagulação realmente se sustenta. Como, quando e para quem?No episódio #217 do DozeCast, Victor Bemfica e Diandro Mota recebem a Dra. Idelzuita Liporace (doutora pela USP e médica assistente do setor de anticoagulação do Instituto Dante Pazzanese) para uma conversa prática e sem simplificações sobre anticoagulação no paciente com doença renal crônica, com destaque para a avançada.

Chad Masterson & Charlie Plainview are the co-founders of OPNET: a protocol that brings smart contracts, DeFi & stablecoins to Bitcoin's base layer. No tokens, wrappers, or bridges are required. But how does it really work & how is it different from Omni, Counterparty, and Citrea? Time stamps: Time stamps: 00:00:36 Introducing Danny and Chad from OPNET 00:01:37 Defining OP NET and Consensus Protocols 00:03:19 Comparison to Counterparty and EVM Compatibility 00:05:39 Technical Implementation: Witness Field and Bitcoin Compliance 00:07:32 Leveraging Bitcoin's Native Scripting 00:09:03 Problems with Meta Protocols and Off-Chain Indexers 00:12:48 Potential for DeFi and Institutional Use 00:14:07 Layer Two Limitations and Liquidity Issues 00:15:35 Scaling and High Fee Environment 00:20:52 Stablecoins and OP 20 Token Standard 00:23:18 Freedom, Use Cases, and Bitcoin's Limitations 00:27:36 Critique of Liquid and Bridging Solutions 00:31:38 Lightning Network, Taproot Assets, and Payments Use Case 00:34:49 Bitcoin Yield, Loans, and Productive Capital 00:37:44 Criticism from Bitcoin Maximalists: Spam and Competing Tokens 00:42:06 Spam, UTXO Bloat, and Account-Based Model 00:44:51 Miner Incentives, MEV, and Transaction Ordering 00:50:04 Sponsor Plugs and Giveaway 01:04:52 OP NET's Target Audience and User Adoption 01:13:00 Bitcoin's Role: Peer-to-Peer Cash or Financial Layer? 01:23:00 Permissionless Innovation and Resilience 01:26:39 Emergent Use Cases and Historical Parallels 01:30:16 Airdrops, Incentives, and Early User Rewards 01:32:33 Security and Comparison Between OP-20 and BRC-20 01:34:18 Live DeFi Applications and Fee Experience 01:36:53 AI Coding FUD and Development Process 01:39:51 Decentralization, Node Operation, and Team Size 01:42:26 Final Questions: Criticisms, Wallets, and How to Try OP NET 01:45:37 Outro and Thanks

Semaglutida. Tirzepatida. Ozempic. Wegovy. Mounjaro. Raramente uma classe de medicamentos entrou tão rápido na prática clínica, e gerou tanta dúvida no consultório.Neste episódio do DozeCast, Mateus Prata e Raphael Rossi recebem o Dr. Eduardo Nakamura, endocrinologista e fundado do @endodirect, para um papo sobre as terapias baseadas em GLP-1: o que a ciência já provou, onde ainda tem lacuna, e como prescrever, ajustar e acompanhar esses pacientes na prática.

Every Bitcoin transaction needs to be verified on the blockchain. There is no central authority that does this, but Bitcoin's blockchain has run uninterrupted since 2009 and now carries a market capitalisation of $1.3 trillion, roughly 4% of US GDP. Its original promise was more radical: that we do not need a trusted intermediary to spend money, write contracts, or create finance. In the fifth LTI report, published today, Yackolley Amoussou-Guenou, Bruno Biais, and Sara Tucci-Piergiovanni ask how much of that promise has held. Bruno talks to Tim Phillips about blockchain's potential, its flaws, and its future.  It is a Nash equilibrium: if you believe others will follow the rules, it is in your interest to follow them too. On that foundation Bitcoin's ledger has been running continuously for 16 years. Smart contracts, pioneered by Vitalik Buterin's Ethereum, extend the logic to financial agreements. Decentralised finance promised to cut out rent-seeking intermediaries. Cryptocurrencies can step in where banks are broken or currencies have collapsed; in Lebanon, when bank accounts were frozen and payments stopped, businesses switched to crypto and kept operating. But the technology's libertarian origins may need to be sacrificed: As Bruno says, without transparency there is no trust, and transparency in this market may require regulation.The research behind this episode:Amoussou-Guenou, Yackolley, Bruno Biais, and Sara Tucci-Piergiovanni. 2026. "Can Blockchain Decentralize Money, Contracts, and Finance?" LTI Report 5. CEPR and Long-Term Investors@UniTo. Freely available to download at cepr.org. To cite this episode:Phillips, Tim, and Bruno Biais. 2025. "Can Blockchain Decentralize Money, Contracts, and Finance?" VoxTalks Economics (podcast). Assign this as extra listening. The citation above is formatted and ready for a reading list or VLE.About the guestBruno Biais is Professor of Finance at HEC Paris and a Research Fellow at the Centre for Economic Policy Research (CEPR). His research spanning financial market microstructure, corporate finance, and the economics of blockchain has made him one of the leading economists working at the intersection of finance and decentralised technology. He has studied blockchain and cryptocurrency markets since their early years, and his theoretical models of consensus mechanisms and cryptocurrency valuation have shaped how economists understand the conditions under which decentralised systems can and cannot sustain themselves.Research cited in this episodeThe blockchain is a distributed ledger maintained by a network of nodes, each holding an identical copy of the record of ownership. When a transaction is submitted, all nodes verify it against the existing ledger and update their copies to reach consensus on the new state. No central authority manages this process; its stability rests entirely on the incentive structure built into the protocol.Nash equilibrium is a concept from game theory, named for the mathematician John Nash, describing a situation in which each participant's strategy is the best response to the strategies of all others; no individual has an incentive to deviate unilaterally. Biais and co-authors identify the Bitcoin protocol as a Nash equilibrium: if you believe others will follow the rules, it is in your own interest to follow them too. That self-reinforcing alignment of incentives, rather than goodwill or central enforcement, is why the blockchain has remained valid since 2009.Smart contracts are lines of code deposited on a blockchain that execute automatically when specified conditions are met: if X, then Y. Vitalik Buterin introduced them through the Ethereum platform, which offers a richer programming language than Bitcoin and allows users to hold collateral on-chain to guarantee the contract will pay out. Smart contracts underpin automated market makers, decentralised lending, and a wide range of financial applications that require no counterparty or intermediary to enforce the agreement.Oracles are third-party services that transmit data about real-world events to a blockchain, allowing smart contracts to respond to things that happen off-chain. A contract that pays out when a house burns, for example, requires an oracle to report that event to the network. Oracles introduce a point of fragility: the authenticity and accuracy of off-chain information must be established before the network accepts it, and that verification is more vulnerable to error and manipulation than the on-chain consensus mechanism itself.Front-running and miner extractable value (MEV) describe the practice by which technically sophisticated actors exploit the public visibility of pending transactions to extract profits at the expense of ordinary users. Because transactions on public blockchains are broadcast to all nodes before they are confirmed, an actor who sees a large pending purchase can execute the same trade first, drive the price up, and then sell at a profit once the original transaction goes through. The cost falls on the smaller trader. Biais notes that the barriers to entry and economies of scale in this activity have concentrated power in the hands of a small, technically skilled group, recreating the kind of intermediary rents that decentralised finance was designed to eliminate.Automated market makers are smart contracts that provide continuous liquidity for trading between two assets by holding reserves of both in a pool and setting prices according to the ratio of the reserves. A large purchase of one asset depletes that side of the pool and raises its price; a large sale depresses it. Automated market makers have become a central mechanism of decentralised finance, replacing the order-book systems used in traditional exchanges.Stablecoins are cryptocurrency tokens designed to maintain a fixed value relative to a conventional currency, typically the US dollar. They are issued by private entities that hold reserves intended to back the peg. Tether, the largest stablecoin by market capitalisation, holds its reserves in a mix of Treasury bills, Bitcoin, and precious metals; in 2021, the US Commodity Futures Trading Commission fined Tether for misrepresenting those reserves and required it to disclose their composition, making this information publicly available for the first time. Dai is an algorithmically managed stablecoin that maintains its peg through over-collateralisation in cryptocurrency rather than conventional reserves.The Diamond-Dybvig model is a theoretical framework developed by Douglas Diamond and Philip Dybvig explaining why financial intermediaries that hold illiquid assets while issuing liquid claims are inherently vulnerable to runs. When enough depositors demand withdrawal simultaneously, the institution is forced to sell assets at a loss, making further withdrawals impossible and confirming the fears that triggered the run. Biais applies this logic to stablecoins: if enough holders attempt to redeem simultaneously, the issuer must sell its reserves in volume, driving down their price and potentially breaking the peg.Central bank digital currencies (CBDCs) are digital tokens issued and managed by central banks, distinct from both commercial bank deposits and private stablecoins. Biais distinguishes two potential use cases: retail CBDCs, which would allow individuals to hold central bank money directly, and wholesale CBDCs, which would facilitate settlement between large financial institutions. He regards the wholesale application as the more promising; a wholesale CBDC could enable fast, low-cost atomic settlement of cross-currency transactions between banks under central bank oversight, a significant improvement on current interbank settlement systems.MiCA (Markets in Crypto-Assets Regulation) is the European Union's regulatory framework for crypto-asset service providers, which came fully into force in December 2024. It requires licensing for issuers and service providers operating within the EU and imposes disclosure, reserve, and conduct requirements intended to align the sector more closely with the standards applied in traditional financial markets.Hayek's currency competition refers to the argument by Friedrich Hayek that competition between privately issued currencies would discipline monetary policy: users would switch away from currencies managed irresponsibly, and that threat would encourage better central bank behaviour. Biais applies this argument to cryptocurrencies and stablecoins in countries where the domestic currency has been mismanaged. He cites Nigeria, where sharp depreciation of the naira was accompanied by rising crypto adoption; over the following period, Nigeria's central bank raised interest rates and created a more transparent foreign exchange market. Biais suggests, tentatively, that the competitive pressure from crypto alternatives may have contributed to that improvement.More VoxTalks EconomicsDo stablecoins threaten financial stability? Stablecoins are digital tokens, pegged to a fiat currency. What could possibly go wrong? For one type of stablecoin the answer is: plenty, according to Richard Portes. In coin we trust Crypto investors make a lot of noise, but who are they, and do they behave differently to other retail investors?Do cryptocurrencies matter? Can cryptocurrencies be useful? Not just for crypto bro speculators, but as a shield against the depreciation of the official currency if a government is determined to pursue inflationary policies.

The Daily Gwei Refuel gives you a recap every other week day on everything that happened in the Ethereum and crypto ecosystems - hosted by Anthony Sassano. Timestamps and links to topics discussed: https://daily-gwei-links.vercel.app/recent 00:00 Introductory song 00:10 The EF mandate https://x.com/ethereumfndn/status/2032460726728573298 https://x.com/barnabemonnot/status/2033089581810077821 23:06 Etherealize on layer 2's https://x.com/Etherealize_io/status/2032091862513684661 28:20 New MaxEB dashboard https://x.com/trent_vanepps/status/2031480995392655689 29:24 $50mil MEV swap https://x.com/bh359/status/2032195231681241218 38:15 Encrypted mempools https://x.com/_julianma/status/2032067843635007508 42:53 BlackRock's staked ETH ETF is now live https://x.com/JSeyff/status/2032204440082460707 This episode is also available on YouTube: https://youtu.be/kJlfuYXewLs Subscribe to the newsletter: https://thedailygwei.substack.com/ Subscribe on YouTube: https://www.youtube.com/channel/UCvCp6vKY5jDr87htKH6hgDA/ Follow Anthony on Twitter: https://twitter.com/sassal0x Follow The Daily Gwei on Twitter: https://twitter.com/thedailygwei Join the Discord Channel: https://discord.gg/4pfUJsENcg DISCLAIMER: All information presented across all of The Daily Gwei's communication channels is strictly for educational purposes and should not be taken as investment advice.

Você otimizou a medicação. Fez a revascularização. E o paciente volta no consultório com dor. O que fazer quando chegamos ao limite das opções convencionais?Neste episódio do DozeCast, Mateus Prata e Fernanda Justo recebem a Dra. Luciana Dourado, cardiologista pelo InCor, especialista em Reabilitação Cardiovascular e Doutora em Ciências Médicas pela USP, para uma conversa aprofundada e prática sobre angina refratária.Um tema que todo cardiologista vai encontrar na prática e que ainda está longe do consenso, inclusive na definição.

In this episode, I sit down with Shresth Agrawal, co-founder of Pod Network, to unpack why the world needs yet another Layer 1.We go deep into MEV, front-running, and why today's blockchain markets are still unfair. Shresth explains how Pod is building a purpose-built L1 designed for high-performance, MEV-free markets. We break down how auctions replace traditional transaction ordering, how Pod can process 300,000 orders per second, and why sub-second settlement changes everything.We also talk about product-market fit in Web3. Are payments and markets the only real use cases? What can founders learn from Ethereum, Hyperliquid, and newer L1s? And what's Pod's go-to-market plan?If you care about fair markets, decentralized finance, or the future of on-chain trading, this episode is for you.

O TEP agudo mudou.O novo Guideline 2026 AHA/ACC redefine a forma como classificamos, diagnosticamos e tratamos embolia pulmonar.No episódio de hoje, Rapha Rossi e Will vão muito além do que chamávamos de  “maciço vs submaciço”.Agora classificamos em categorias A–E, integrando clínica, biomarcadores, imagem de VD e risco de deterioração.Neste episódio do DozeCast você vai entender:

This conversation covers the latest developments in the crypto space, focusing on the Cardano ecosystem, particularly the launch of USDC, liquidity improvements, and the innovative Midnight Network. It discusses the importance of user experience in crypto transactions, the emergence of projects on Midnight, and the challenges posed by Maximal Extractable Value (MEV) bots. Additionally, it highlights partnerships and the future of Cardano, including hardware preparations for becoming a Midnight validator.TakeawaysThe Korean government accidentally compromised a seed phrase.USDC is now available on the Cardano ecosystem, enhancing liquidity.Cross-chain capabilities are improving for Cardano.User experience for USDC transactions needs enhancement.Midnight Network focuses on privacy and selective disclosure.Several projects are already building on Midnight.MEV bots pose a significant risk to users in crypto transactions.Partnerships like Pair Point are crucial for Midnight's success.The Cardano Foundation is expanding its educational resources through Binance Academy.Hardware is essential for becoming a Midnight validator.Chapters00:00 Intro02:51 USDC on Cardano14:13 Pyth is next!15:44 Midnight City17:42 Projects Building on Midnight21:16 Privacy prevents MEV attacks23:41 Midnight and Pairpoint25:07 Cardano Foundation Institutional Adoption Track26:09 Cardano Scaling is Coming29:08 Cardano on Binance Academy29:54 Strike is Killing it30:58 Mithril Signers32:11 Midnight Node Incoming36:18 SupportDISCLAIMER: This content is for informational and educational purposes only and is not financial, investment, or legal advice. I am not affiliated with, nor compensated by, the project discussed—no tokens, payments, or incentives received. I do not hold a stake in the project, including private or future allocations. All views are my own, based on public information. Always do your own research and consult a licensed advisor before investing. Crypto investments carry high risk, and past performance is no guarantee of future results. I am not responsible for any decisions you make based on this content.

Dean Eigenmann, Co-Founder of Market Start Inc, joins us to talk about the massive shift in crypto market dynamics. Dean explains his transition from the "closeted" world of MEV trading to launching a liquid-focused fund. We discuss why venture capital overhang has left the market without marginal buyers and why "crypto mullets" are the future of critical infrastructure. Dean also breaks down the math behind token buybacks, comparing the success of Hyperliquid to the struggles of Helium and Jupiter. Subscribe to the newsletter! https://newsletter.blockspacemedia.com Notes: → Tokens should be equity → Hyperliquid 11 employees → Jane Street conspiracy Timestamps: 00:00 Start 00:28 Pivoting away from trading 01:11 The acquisition & current MEV landscape 02:11 Markets Inc 04:09 Token framework 05:24 Regulations & other barriers 07:41 Buy backs 09:37 Hyperliquid buy back program 11:33 HYPE 12:49 Inflection point 13:51 Markets Inc scale & project development phases 16:25 ellipsis labs 17:13 What does "helping" projects mean? 20:58 Real time trade finance 23:48 Stablecoins & efficiency gains 25:25 Tokens vs equity 26:01 Investing in stablecoin infrastructure 28:25 Other sectors 29:39 What's NOT investable now? 30:17 But but DePIN... right? 33:41 Projects with sustainable demand? 35:24 AAVE drama 37:13 AAVE DAO & project structure 39:39 Morpho 40:53 Prediction markets 44:11 What's insider trading & Jane Street 45:59 Jane Street conspiracy 47:56 Wrap up The Gwart Show is sponsored by Ellipsis Labs. Ellipsis Labs builds the most efficient on-chain markets. Their orderbook and Prop AMM products have delivered price improvement to hundreds of billions of dollars in retail volume. Now, they are bringing their expertise to build Phoenix, the best on-chain perpetuals platform. Ellipsis Labs is hiring New York-based engineers. If you're an engineer looking to work with a proven team in making DeFi better, go to ellipsislabs dot xyz slash careers. Learn more about your ad choices. Visit megaphone.fm/adchoices

A Diretriz Brasileira de Fibrilação Atrial 2025 muda o eixo da conversa.FA agora é formalmente tratada como doença progressiva e modificável — e isso muda quando anticoagular, quando buscar ritmo e quando indicar ablação.No DozeCast #213, Raquel Rios e Diandro Mota fazem um resumo prático e direto ao ponto do que realmente impacta o dia a dia.Você vai ouvir sobre:

Gm! In this episode we discuss Blockworks' new Solana-focused Lightspeed IR platform and a report on Solana block building. We examine the rivalry between Jito BAM and Harmonic, impacts on transaction ordering, fees, market structure, validator clients, and the push toward protocol-level solutions like MCP and application-controlled execution.Enjoy! -- Follow Lightspeed: ⁠https://twitter.com/Lightspeedpodhq⁠ Follow Sam: https://x.com/minnus Follow Carlos: https://x.com/0xcarlosg Follow Danny: https://x.com/defi_kay_ Join the Lightspeed Telegram: ⁠https://t.me/+QHlbNTNS4gc1ZTVh -- Join us at DAS (Digital Asset Summit) in New York City this March!  Use the link below to learn more, and use code LIGHTSPEED200  to get $200 off your ticket! See you there! Learn more + get your ticket here: https://blockworks.co/event/digital-asset-summit-nyc-2026 -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- Timestamps: (0:00) Introduction (3:42) Lightspeed IR Platform Launch (6:40) Block Building on Solana (12:28) Jito Bam vs. Harmonic: Architecture Breakdown (16:51) MEV, Fees, and Market Structure Impacts (34:04) MCP and Solana's Path Forward (48:49) What Happened to Jito and Harmonic? (55:55) Alpenglow & MCP Timeline (59:03) Closing Comments -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Danny, and our guests may hold positions in the companies, funds, or projects discussed.

O tratamento de amiloidose e cardiomiopatia hipertrófica mudou de patamar. O que antes era “manejo de sintomas + rezar” virou era de terapias-alvo, com impacto real em desfechos e qualidade de vida.No DozeCast #212, Victor Bemfica e Plínio Wolf fazem um passeio completo pelo passado, presente e futuro dessas duas cardiomiopatias que, finalmente, ganharam armas de verdade.Falamos sobre:Amiloidose (ATTR) • Tipos: wild-type vs hereditária e por que isso muda o jogo • Clínica além do coração: músculo-esquelético, disautonomia, neuropatia, TGI • Diagnóstico: o fluxograma pra não perder tempo (e não errar feio) • Tratamento “inespecífico” da cardiomiopatia: – IC na amiloidose: por que o quarteto clássico costuma falhar e por que o diurético é rei (com o “lençol curto” congestão vs hipovolemia) – iSGLT2 e ARM: o que já dá pra defender com dados – Quando IECA/BRA/BB atrapalham mais do que ajudam – Arritmias, marcapasso, FA, tromboembolismo: o que muda na conduta • Tratamento específico da transtirretina: – Estabilizadores (tafamidis e a nova geração) – Silenciadores (RNA/antisense) e a corrida pelo melhor desfecho – O que vem aí: depletadores e o “futuro” que promete • Desafios reais: custo, acesso, timing da terapia e por que não é curaCardiomiopatia Hipertrófica (CMH) • Obstrutiva vs não obstrutiva: fisiopatologia e como isso direciona terapia • Epidemiologia e prognóstico: por que a mortalidade caiu e o que ainda mata • Controle de sintomas: do beta-bloqueador raiz até a decisão de reduzir septo – Miectomia vs alcoolização vs RF: quem é o melhor candidato pra quê • A revolução dos inibidores de miosina: mecanismo, indicações e onde eles entram no algoritmo • CMH não obstrutiva: por que nem tudo que brilha é miosina • Prevenção de morte súbita: CDI e as principais indicações (sem romantização)

Dispositivos Cardíacos Eletrônicos Implantáveis (DCEI) fazem parte da rotina de qualquer cardiologista — mas seguem cercados de dúvidas, mitos e decisões tomadas “por insegurança”, especialmente no plantão.Neste episódio do DozeCast, apresentamos um guia prático de DCEI, com foco em marcapasso, CDI e marcapasso provisório, abordando o que realmente muda conduta, evita erro e aumenta segurança no cuidado do paciente.Um episódio pensado para quem está no PS, na enfermaria, no consultório — e não quer errar no básico.Introdução — DCEI no mundo real Por que marcapasso e CDI ainda geram tanta confusão no dia a dia clínico.IMA + dispositivos: onde mora o erro – IMA + marcapasso: quando realmente indicar – IMA + CDI: timing, risco e falsas urgênciasMarcapasso provisório na prática: dicas que salvam – Indicações corretas vs “implante por insegurança” – Programação mínima que todo cardiologista deveria saber – Dicas de implante: acesso, complicações e armadilhas – Quando não insistir no MP provisório – Overdrive pacing na tempestade elétrica: quando faz sentidoComplicações mais comuns de DCEI – Infecção de loja – Perfuração – Trombose – Estímulo frênico: como reconhecer e conduzirECG em pacientes com marcapasso – Como identificar espícula no ECG – Diferença prática entre estimulação unipolar e bipolar – Por que às vezes “não aparece espícula” – Erros clássicos de interpretação no plantão – Taquicardia induzida, mediada e conduzida – PVARP (Período Refratário Atrial Pós-Evento Ventricular) sem mistérioDCEI e atividade física – O que é permitido – O que exige cuidado – Esporte competitivo, musculação e impacto – Como orientar sem proibir tudoMitos e verdades que todo médico ouve – Micro-ondas, porta de banco e aeroporto – Celular, smartwatch e fones magnéticos – Procedimentos cirúrgicos com eletrocautério – Ressonância magnética – Fisioterapia com corrente elétrica – Dentista – PCR e choque externo – RadioterapiaSe você quer ganhar segurança real com marcapasso e CDI, evitar armadilhas comuns e tomar decisões melhores no plantão e no consultório, esse episódio é pra você. ⚡

MegaETH mainnet is live, kicking off a new frontier for Ethereum scaling: ultra-low latency, massive throughput, and an execution environment built to unlock apps that can't exist on L1. Lei Yang & Namik break down why Vitalik's latest L2 framing validates “barbell” scaling, what users actually inherit from Ethereum (censorship resistance, exit guarantees, and fraud-proof security assumptions), and why stages + governance are harder than they look.  Plus: the mainnet stress test (11.4B tx in 7 days, 55k peak TPS), the economics shift toward stablecoin yield with USDM, proximity markets for MEV, and MegaETH's aggressive app-incubation strategy. ------

A doença hipertensiva da gestação não é “só pressão alta na gravidez” — é um espectro com risco materno-fetal real e decisões que, no plantão, não perdoam hesitação.No DozeCast #210, Raphael Rossi e Victor Bemfica revisam o que você precisa dominar para conduzir HAS na gestação com segurança, do consultório à emergência.Falamos sobre: • Como definir e classificar: HAS crônica, HAS gestacional, pré-eclâmpsia e HAS sobreposta • O que muda o jogo na pré-eclâmpsia: proteinúria e/ou disfunção de órgão-alvo (rim, fígado, plaquetas, pulmão, SNC) • Hipertensão grave (≥160/110): entenda a urgência, mesmo sem sintomas • Prevenção: AAS em baixa dose no timing correto e quando considerar cálcio (ainda tem espaço?) • Quando tratar e qual alvo perseguir: tendência atual a controle mais rigoroso sem comprometer perfusão placentária • As drogas seguras na gestação e no puerpério • Manejo da crise hipertensiva: meta de redução e principais armadilhas • Puerpério: por que a PA pode piorar em 3–6 dias e como orientar sinais de alarme e seguimento

In this episode, host Friederike Ernst is joined by Thomas Thiery, a researcher at the Ethereum Foundation, to discuss EIP-7805 and the implementation of FOCIL (Fork-Choice Enforced Inclusion Lists). Thomas explains how the rise of MEV (Maximal Extractable Value) has created a centralized builder market where a few actors now control over 85% of Ethereum's block production, creating a dangerous bottleneck for censorship. FOCIL addresses this by empowering a decentralized committee of 16 validators to mandate transaction inclusion, making any block that ignores these lists invalid. They explore the "Tornado Cash" moment and the risks of "silent censorship" for competitive or regulatory reasons. Thomas explains why FOCIL intentionally prioritizes the public mempool over MEV-heavy transactions to prevent the system from being co-opted. Finally, the conversation looks at the future of the Ethereum roadmap, including the Osaka fork and the technical trade-offs between inclusion lists and long-term privacy solutions like encrypted mempools. Topics00:00 Intro & FOCIL04:15 MEV & Centralization09:30 The Builder-Searcher Pipeline15:00 Silent Censorship Risks21:45 FOCIL Architecture & Committees27:10 Validity Rules for Attestors35:20 Spam Protection & Invalid TXs42:15 FOCIL vs. Encrypted Mempools49:00 EIP-7805 Status & Fork Timelines55:30 Future: PQC & ZK EVMLinksThomas Thiery on X: https://x.com/soispoke Ethereum Foundation: https://ethereum.foundation/ EIP-7805 (FOCIL): https://eips.ethereum.org/EIPS/eip-7805 Gnosis: https://gnosis.io/Sponsors: Gnosis: Gnosis has been building core decentralized infrastructure for the Ethereum ecosystem since 2015. With the launch of Gnosis Pay last year, we introduced the world's first Decentralized Payment Network. Start leveraging its power today at http://gnosis.io

In this episode of FYI – For Your Innovation, ARK's Cathie Wood speaks with Don Wilson, a pioneer in crypto market infrastructure and the founder of DRW and Cumberland. They discuss the accelerating shift of traditional finance onto blockchains, focusing on the emergence of the Canton Network, a public permissionless blockchain designed for institutions—with privacy and permissioning at its core. Don unpacks why Depository Trust and Clearing Corporation's (DTCC's) decision to tokenize U.S. Treasuries on Canton marks a turning point in institutional adoption, how Canton balances decentralization with control, and what makes it uniquely suited for real-world asset (RWA) tokenization. The conversation covers stablecoins, the evolving role of private credit and equity, and how tokenization might reshape collateral, leverage, and capital efficiency. Don also offers sharp takes on Maximal Extractable Value (MEV) vs. payment for order flow, prediction markets, and whether we're still in a “four-year crypto cycle.” A must-listen for those tracking the future of digital asset infrastructure.Key Points From This Episode:[00:00] Intro + Why tokenization matters: reducing costs, unlocking capital efficiency, and ARK's thesis on blockchain infrastructure[06:27] Don Wilson's background, early crypto involvement, and the founding of Cumberland and Canton[09:57] Why privacy and permissioning are essential for institutional blockchains[13:44] DTCC's adoption of the Canton Network and the mechanics of tokenizing U.S. Treasuries[25:05] Real-world benefits of tokenization: collateral mobility, after-hours lending, and stablecoin settlement[29:23] Prediction markets: institutional vs. retail use cases and the importance of privacy on-chain[35:13 – 37:23] Scaling Canton: new strategic investors and trillions in tokenized assets already on-chain[37:25 – 47:34] Private equity and credit on-chain: implications for efficiency, leverage, and retail access[47:34] MEV vs. payment for order flow: why Don believes MEV resembles illegal front-running[48:18] Crypto market structure: October flash crash, ETFs, and institutional buyers in the current cycle[55:10] Closing remarks

As Diretrizes Alimentares Americanas 2025–2030 mudaram a forma oficial como os EUA enxergam a alimentação saudável — e a nova “pirâmide alimentar” virou motivo de entusiasmo e polêmica ao mesmo tempo. A gordura para de ser a grande vilã, os ultraprocessados entram no centro das críticas, a proteína ganha protagonismo na base da dieta e os laticínios integrais voltam com mais força. Mas… isso faz sentido à luz da ciência?No episódio, Mateus Prata e Diandro Mota recebem a nutricionista Dra. Daniela Seixas (UFPR, doutora em Bioquímica, pós-doc USP e autora de Compostos Bioativos dos Alimentos) para destrinchar, com embasamento e senso crítico, as Diretrizes Alimentares Americanas 2025–2030 e a nova pirâmide.O que você vai ouvir:Introdução às Diretrizes 2025–2030: quem faz, para quem servem e por que esse documento importa para o Brasil.Mudança de vilão: saiu a gordura como foco principal, entrou o ultraprocessado como alvo central.O que é ultraprocessado, por que ele domina o prato das pessoas e como traduzir “evite ultraprocessados” em escolhas reais.Comida de verdade, mas proteína no centro: a recomendação de 1,2–1,6 g/kg/dia de proteína como novo “normal” populacional.Laticínios integrais e gordura saturada: limite de 10% de saturada mantido, mas com espaço para laticínios integrais e até manteiga/sebo em moderação!! Isso está correto?Frutas, vegetais e dietas plant-based: o tratamento às dietas vegetarianas/veganas: ênfase em riscos e deficiências, mas pouco foco nas falhas da dieta onívora padrão.Política, ciência e bastidores: o papel do relatório de 2023–2024 e o “apagamento” de algumas recomendações no produto final.Se você quer entender o que há de realmente sólido nessas novas recomendações, o que pode impactar risco cardiometabólico e o que deve ser lido com cautela, esse episódio é pra você.

This episode is with Anna George, co-founder & CEO of CowSwap / Cow Protocol (originally built inside Gnosis, spun out in 2022). What's wild is Anna spent about a decade in humanitarian/UN work before getting pulled into crypto in 2017 - partly because she wanted impact, and partly because UN bureaucracy will make anyone want to run away and build something. We talk about the real CowSwap origin story: the early DEX experiments that didn't work (including six-hour auctions… lol), the liquidity chicken-and-egg problem, and how CowSwap finally hit product-market fit with intent-based trading, MEV protection, and “you only pay gas if the trade actually executes.” We also cover where they're going next: cross-chain swaps that don't feel like bridging hell, deeper DeFi integrations (including Aave), and a bigger push to make crypto UX not terrible.

Kevin Lepsoe is the Founder of ETHGAS.What if Ethereum could feel instant? In this episode, we explore whether blockspace futures trading could pave the way toward a gasless, real-time Ethereum, and what that would mean for DeFi, MEV, validators, and the broader L2 scaling roadmap.------

Join Alex Tapscott as he decodes the world of crypto with special guest Thomas Uhm, Chief Commercial Officer at the Jito Foundation and Advisor to Jito Labs. Listen in as they discuss what Abu Dhabi Finance Week and Solana Breakpoint reveal about institutional crypto sentiment, why ADGM is emerging as a serious hub for digital asset regulation and capital formation (with major players spanning BlackRock, Circle, Tether and more), how Solana's market structure is evolving through Jito's block-building, priority-fee "tips," and the upcoming BAM framework for application-controlled execution, what MEV is and how networks can reduce harmful forms of it while still securing validators, why Solana's performance under large DDoS pressure reinforces the "internet capital markets" thesis, and what 2026 could bring—from JitoSOL liquid-staking ETFs (and an options-driven structured products wave) to Breakpoint landing in London.

In this episode, Jonathan Schmalfeld and Jacob Robinson walk through the biggest crypto law and policy developments of the month of November. Jonathan is the Policy Director at The Digital Chamber, where he leads federal and state advocacy on digital asset regulation. Timestamps:➡️ 1:19 — Senate Agriculture Committee releases market structure draft➡️ 3:22 — Why DeFi and AML sections remain blank➡️ 3:52 — Chair Atkins' speech and push for taxonomy➡️ 6:32 — Treasury & IRS guidance on staking ETFs➡️ 10:39 — Uniswap's fee switch vote and winding down➡️ 13:53 — Coinbase reincorporates from Delaware to Texas➡️ 16:19 — MEV exploit trial ends in mistrial➡️ 23:36 — Samurai Wallet sentencing and liability risks➡️ 26:55 — DOJ's Tornado Cash filing and self-custody issues➡️ 30:29 — Digital Chamber launches State Network➡️ 33:37 — OCC guidance allowing banks pay gas fees➡️ 36:50 — What to watch next in GENIUS implementationSponsor: Day One Law, a boutique corporate law firm founded by Nick Pullman. Nick and his team at Day One provide strategic legal counsel to startups, crypto projects, and Web3 innovators. ⁠You can get in contact with them via this link⁠: ⁠⁠https://www.dayonelaw.xyz/#contact

The price of bitcoin (BTC-USD) and ether (ETH-USD) slipped lower on Thursday despite the US Federal Reserve cutting interest rates, as Fed chair Jerome Powell signalled the central bank will proceed cautiously into 2026.~This Episode is sponsored by BTCC & Mevolaxy~BTCC 10% Deposit Bonus! ➜ https://bit.ly/PBNBTCCMevolaxy - get a 50% discount on the Pro account & a 10% bonus on your first MEV-stake. The offer is valid for 48 hours!https://bit.ly/MevolaxyPBN00:00 Intro00:10 Sponsor: BTCC00:45 Neutral01:30 Crypto is lagging02:15 No Santa rally?03:00 Fear & greed03:30 Silver Surges04:30 Elizabeth Warren: Should they have cut 50?06:30 Paths to more cuts in 202608:00 Global cuts happening08:30 Will Bitcoin hit $70K soon?09:00 QE here?10:10 Bloomberg: This sounds like QE12:00 Steve Eisman on AI: It's not about the Fed14:50 Manifesting crashes16:50 Sponsor: Mevolaxy19:00 ETH vs BTC20:10 Solana Breakpoint21:30 Borrow against Polymarket positions… Disaster waiting to happen?22:20 Crypto Regulation on the edge23:00 HYPE Dead?23:30 Outro#Crypto #bitcoin #ethereum~Fed Rate Cut Reaction

At DevConnect 2025, Sebastian and Friederike speak with Peter Van Valkenburgh about the rapidly evolving battle for digital rights. Peter challenges the industry's comfort with transparency, arguing that "transparency will destroy neutrality." He uses the history of SWIFT to illustrate how a once-neutral messaging system was captured by geopolitical interests because it wasn't "technically blind" to the data it processed. He argues that for blockchains to survive as global settlement layers, they must be "actually blind" to transactions, making neutrality a technical reality rather than a policy choice.The conversation turns to the aggressive legal tactics currently deployed against developers. Peter highlights the Pereira Bueno case, where prosecutors charged MEV searchers with wire fraud for being "dishonest validators" a concept Peter argues completely undermines the game-theoretic security of permissionless networks. He also breaks down the mixed bag of Tornado Cash litigation. While the sanctions against the protocol were successfully challenged and invalidated for Americans, the criminal conviction of developer Roman Storm for "unlicensed money transmission" sets a terrifying precedent for anyone publishing open-source code.On a constructive note, Peter introduces Coin Center's "John Hancock Project," which advocates for replacing the current, ineffective KYC/AML regime (which seizes less than 1% of illicit funds) with a system based on privacy-preserving attestations and self-sovereign risk scores. Finally, Peter shares surprising optimism regarding the US Securities and Exchange Commission (SEC). He notes that under the influence of Commissioners Hester Peirce and Paul Atkins, the agency has shifted from an aggressive adversary to a potential ally, openly discussing the benefits of full asset tokenization and the constitutional necessity of financial privacy.Topics00:00 The Telegram vs. Signal security rant05:15 The "Transparency Paradox": Why transparent Layer 1s cannot remain neutral in the long run10:40 The SWIFT Analogy: How a neutral messaging layer became a politicized settlement enforcer15:50 The Pereira Bueno Case: Why labeling MEV strategies as "wire fraud" threatens all validators23:10 L2 Sequencing Risks: Centralization and the need for "dumb pipes" 28:30 The Failure of KYC: Why 99.8% of illicit funds are missed and the cost of mass surveillance35:00 The "John Hancock Project": Using ZK-proofs and attestations to replace identity surveillance42:15 Tornado Cash Update: Sanctions invalidated vs. the dangerous precedent of Roman Storm's conviction49:00 The SEC's 180: Hester Peirce, Paul Atkins, and the push for tokenized equitiesLinks mentioned in the episode: Gnosis: https://gnosis.io/ Coin Center: https://www.coincenter.orgEpicenter - All Episodes: https://epicenter.tv/Report: Tear Down This Walled Garden: https://www.coincenter.org/tear-down-this-walled-garden/ Pereira Bueno Amicus Brief: https://www.coincenter.org/amicus-brief-mev-wire-fraud/ Peter on X: https://x.com/valkenburghSebastian on X: https://x.com/seb3point0Friederike on X: https://x.com/tw_tter Sponsors:Gnosis: Gnosis has been building core decentralized infrastructure for the Ethereum ecosystem since 2015. With the launch of Gnosis Pay last year, we introduced the world's first Decentralized Payment Network. Start leveraging its power today at http://gnosis.io

Welcome to The Chopping Block — where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. This week, the crew dives into the shift from airdrops to ICOs as Monad, MegaETH, and Coinbase's new sale format spark a rethink of how tokens should be distributed. They discuss ICO Beast's hedging fiasco, why most airdrops fail to create real users, and whether fixed-price ICOs are a better path for long-term alignment. The gang also unpacks Uniswap's major “unification,” the end of Labs vs. Foundation, and UNI finally becoming the protocol's value-accrual asset. In the back half, they touch on the “low carb crusader” MEV trial, the hung jury, and the broader question of whether MEV games belong in criminal court at all. A concise, high-signal look at where tokenomics, distribution, and crypto's legal boundaries are heading next. Show highlights

“‘The battle belongs to the Lord” (1 Samuel 17:47 MEV). When everyone stared at Goliath, David never gave him the...