Podcasts about dao

In part one, Dr. Liz Bartman and I broke down why PMDD happens: the histamine surges, the GABA receptor glitch, the progesterone metabolite that either calms you down or completely wrecks you depending on your unique biology. If you haven't listened to that one yet, start there, because this episode builds directly on it. Now we get into the part everyone actually wants to know: what do you do about it? We talk about why popular fixes like DAO supplements and strict low histamine diets usually fall short, and what to focus on instead, starting with your gut, your liver, and your nervous system. Dr. Liz walks through her actual clinical protocols, including specific nutrients, herbs, and the EndoAccess formulas she uses with patients who have histamine overload, progesterone sensitivity, or both. We also get into the harder conversations: when a 5-alpha reductase inhibitor might help women who are pushing too much allopregnanolone, what's really going on hormonally for women hitting perimenopause with worsening PMDD, and yes, when birth control or even an SSRI might actually be the safest, most compassionate choice, even for someone who leans natural. Dr. Liz makes a case that will challenge how you think about "first, do no harm." This episode is about giving you an actual roadmap, not just information. Because once you understand your own biology, from part one, you can finally stop guessing and start treating the right thing. In This Episode, We Cover: Why DAO supplements and strict low histamine diets usually don't solve the problem long term The gut, liver, and nervous system focused approach Dr. Liz uses first with patients Key nutrients and antioxidants for calming histamine and neuroinflammation, including glutathione support, sulforaphane, green tea, pomegranate, curcumin, NAC, and glycine Why alcohol is one of the biggest hidden disruptors of histamine clearance and hormone balance Specific probiotic strains, including lactobacillus plantarum, and their surprising role in GABA receptor expression The EndoAccess formulas Dr. Liz uses clinically for histamine support and for progesterone sensitive PMDD, including early results from a small group of patients What 5-alpha reductase inhibition is, how it relates to allopregnanolone, and when it may help Why perimenopausal women can suddenly develop worse PMDD, and the surprising role of testosterone, insulin, and FSH The honest conversation about birth control, newer options, and when it may be the safest choice for severe PMDD Where SSRIs fit in, including luteal phase only dosing and what to support alongside them Why the nervous system piece is the part most women skip, and why it may be the most important one Who This Episode Is For This is for women who now understand why they're struggling, from part one, and want an actual plan. It's for anyone who has tried supplements or progesterone with no luck and felt like they were out of options. It's especially for women in perimenopause noticing their PMDD or PMS getting dramatically worse, and for anyone who has felt conflicted about whether birth control or an SSRI could ever be the "right" choice for them.     Sponsors Join the Midlife Women's Peptide Program today and get started for less than $200 a month! Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE Get 15% off Magnesium Breakthrough By BiOptimzers at bioptimizers.com/hormone with coupon code HORMONE.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

"Most of the money problems we talk about with Bitcoin — they're not money problems. They're time problems." Scott Dedels — founder of Block Rewards and author of The Age of Time — says the clock is a technology. It was invented about 600 years ago, and somewhere along the way we forgot it was ever invented at all. His claim: the problem of time is upstream of the problem of money. Fiat was downstream of a civilization that had already agreed to be ruled by a machine that only moves forward, in the direction of consumption. We went from asking what is time to only ever asking what time is it. We get into the Prague Orloj and the birth of mechanical time, the 1944 essay that turned time into a commodity, Saturn as civilization's invisible operating system, why we stopped building 300-year cathedrals, AI and the information hyperstream — and Bitcoin as a ten-minute heartbeat no one controls. Subscribe so you never miss an episode.

「日本の文化財守る「DAO」に熱視線　6割が海外からの出資」　「地魚の刺し身」に、「タイの酒蒸し」など日本食に舌鼓を打つ外国人たち。ですが、観光だけが目的で来日したわけではありません。日本の文化財を守るために名乗りをあげた人たちです。存続が危ぶまれた貴重な文化財に新たな息吹を与え、未来へ継承していく取り組みを追いました。日本最大の離島、新潟・佐渡島。かつて順徳上皇や世阿弥などが流され、さまざまな文化が発展してきたこの島には、世界文化遺産に登録された「佐渡金山」を筆頭に貴重な文化財や建造物が数多く存在しています。築350年の歴史を誇る「北條家住宅」は、代々漢方医として活躍してきた北條道益の一族が暮らした家で、母屋は国の重要文化財に指定されています。ただ、味噌蔵や米蔵、家財蔵などは登録有形文化財となっていて、11代目当主の弟・北條規さんはその維持費用に長年、頭を悩ませてきました。北條家11代目当主の弟・北條規さん：登録有形文化財は100％所有者が維持管理費用を出さないといけないので途方にくれていたが、先祖から代々守り続けてきたものを失いたくない、何かいい方法はないかと。そこで北條さんは「DAO」という組織を活用することを決めました。「DAO」とは管理者などが存在せず、参加者が投票で意思決定を行う組織のこと。北條家のプロジェクトでは出資者が共同のオーナーになり配当と議決権が、また地域住民にも議決権が与えられます。集めた資金を使って建物を修繕し、米蔵と味噌蔵などを宿泊可能な文化交流施設へと生まれ変わらせる計画です。このプロジェクトの出資を募ったところ、6割以上が海外からでした。Planet Labs・西村環希代表：日本の方々からするとお寺、古民家、日本家屋、そういったものは見慣れたもの。ただ海外からするとすごく珍しいということで、とても投資が集まった。修繕が始まる前の北條家滞在イベントには、香港やシンガポール、台湾など国内外から出資者が集結しました。現在一般には公開されていない住宅や蔵の内部をじっくり見て回ります。

El director de informativos de Onda Cero, Julián Cabrera, pone epílogo a una semana en la que se han producido hechos históricos y otros inéditos. Histórico ha sido el fin de la Verja de Gibraltar que daba paso a una nueva etapa entre España y el Peñón. Inéditos han sido las comparecencias ante el juez del DAO, la condena al hermano del presidente Pedro Sánchez y la confirmación del procesamiento a Begoña Gómez.

Hoy en la tertulia con Marcela Reigía, Javier Fresneda y Percival Manglano.

Cap's founders on shrinking their Stabledrop from $11M to $4M — plus a $23M hack traced toward North Korea, a BarnBridge governance exploit, and Kain's case to force weak L2s to become their own L1s. ======================================================== Thank you to our sponsors! ⁠⁠⁠Cape⁠⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at ⁠https://cape.co/unchained⁠ (use code: UNCHAINED). ======================================================== Cap committed to a roughly 11 million dollar Stabledrop in February, promising early users stablecoins instead of tokens. A delayed token sale raised less than hoped, and the reward shrank to about 4 million, forcing a fast rewrite of who got paid. Benjamin Sarquis Peillard, Founder and CEO of Cap, and Weso of Cap join Kain Warwick and Taylor Monahan to walk through a restructuring that made yield-token holders whole, left farmers without a windfall, and argue points programs are an uncapped marketing expense many projects cannot afford. The conversation widens into EthSystems, a new Ethereum Foundation spinout backed by Joe Lubin, SharpLink and BitMine, Jesse Pollak handing Base product leadership to Cobie, Robinhood Chain's Morpho integration, and whether Ethereum mainnet undercharges L2s. They revisit BarnBridge's SEC-era DAO structure, a dormant governance exploit, a MetaMask and Revoke.cash delegation tool, and a 23 million dollar Ostium hack Taylor traced toward North Korea. Kain closes with a Three Mile Island analogy: complex systems fail not from one mistake, but from small shortcuts compounding at once. Hosts: ⁠⁠⁠Kain Warwick⁠⁠⁠ - Host of Uneasy Money and Founder of Infinex and Synthetix ⁠⁠⁠Taylor Monahan⁠⁠⁠ - Co-host of Uneasy Money and Security Expert Guests: Benjamin Sarquis Peillard - Founder and CEO of Cap Weso - Co-Founder of Cap Timestamps

España disputa la final del Mundial contra Argentina. Lamine Yamal y Pedro Porro están listos. La Familia Real y Pedro Sánchez asisten al partido en Nueva York. Cope ofrece una cobertura especial. Aragón sufre un gran incendio en Ores, con casi 14.000 hectáreas quemadas y aún fuera de control, luchando por proteger Uesía. En Guadalajara, el fuego quema 3.500 hectáreas y provoca evacuaciones. Málaga confina vecinos por humo. Otros incendios en Sevilla y Madrid se controlan o estabilizan. La UCO investiga a Santos Cerdán por un aumento patrimonial de más de 300.000 euros, vinculado a Ábalos en Fomento, y a su esposa por un presunto cobro sin trabajar. Mercedes González, directora de la Guardia Civil, declara como investigada, se presenta como víctima y niega implicación en "cloacas". Manuel Llamas, DAO, critica a la UCO y se niega a dimitir, con el respaldo de Moncloa. Un general denuncia presiones políticas. El programa repasa la historia del grupo musical Los Diablos, desde sus ...

Cap's founders on shrinking their Stabledrop from $11M to $4M — plus a $23M hack traced toward North Korea, a BarnBridge governance exploit, and Kain's case to force weak L2s to become their own L1s. ======================================================== Thank you to our sponsors! ⁠⁠⁠Cape⁠⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at ⁠https://cape.co/unchained⁠ (use code: UNCHAINED). ======================================================== Cap committed to a roughly 11 million dollar Stabledrop in February, promising early users stablecoins instead of tokens. A delayed token sale raised less than hoped, and the reward shrank to about 4 million, forcing a fast rewrite of who got paid. Benjamin Sarquis Peillard, Founder and CEO of Cap, and Weso of Cap join Kain Warwick and Taylor Monahan to walk through a restructuring that made yield-token holders whole, left farmers without a windfall, and argue points programs are an uncapped marketing expense many projects cannot afford. The conversation widens into EthSystems, a new Ethereum Foundation spinout backed by Joe Lubin, SharpLink and BitMine, Jesse Pollak handing Base product leadership to Cobie, Robinhood Chain's Morpho integration, and whether Ethereum mainnet undercharges L2s. They revisit BarnBridge's SEC-era DAO structure, a dormant governance exploit, a MetaMask and Revoke.cash delegation tool, and a 23 million dollar Ostium hack Taylor traced toward North Korea. Kain closes with a Three Mile Island analogy: complex systems fail not from one mistake, but from small shortcuts compounding at once. Hosts: ⁠⁠⁠Kain Warwick⁠⁠⁠ - Host of Uneasy Money and Founder of Infinex and Synthetix ⁠⁠⁠Taylor Monahan⁠⁠⁠ - Co-host of Uneasy Money and Security Expert Guests: Benjamin Sarquis Peillard - Founder and CEO of Cap Weso - Co-Founder of Cap Timestamps

El Partido Popular critica la permanencia de la directora de la Guardia Civil, Mercedes González, y el DAO en sus cargos tras ser investigados por manipulación judicial. Seis meses después del accidente de Adamuz, un superviviente y la asociación de víctimas denuncian que el tren sigue sin ser seguro. Además, España se prepara para la tercera ola de calor del verano, con Andalucía esperando hasta 20 días de altas temperaturas, mientras la DGT activa un dispositivo especial por la operación salida, reportando varias complicaciones en el tráfico. La final del Mundial de Fútbol entre España y Argentina genera gran expectación, analizando la preparación de la selección, las tácticas y la intensa rivalidad. Una cardióloga ofrece consejos para ver el partido sin riesgos para la salud, como elegir un ambiente tranquilo, evitar excesos en comida y bebida, tomar la medicación a tiempo, hacer pausas e identificar síntomas cardíacos. El festival La Mar de Músicas en Cartagena celebra su 31ª ...

Marriottアンバサダーエリートは得しそう。まだまだ今後の続報待ち、様子見ですね。 ●JALのプレスリリース https://press.jal.co.jp/ja/release/202607/009614.html ーーーーーーーー

La Audiencia de Madrid respalda al juez Peinado y manda a juicio a Begoña Gómez; Begoña Gómez recupera el pasaporte tras levantar la Audiencia las cautelares de Peinado; El Tribunal de la UE allana el regreso de Puigdemont a España; y el DAO desmiente a la UCO: no pidió «ponerse de perfil» cuando investigaba a David Sánchez.Todo esto se lo contamos en una nueva edición de Sumario de tarde, el podcast diario de THE OBJECTIVE. Dirige el espacio, Luis Rafael.

Nick Almond and Proph3t on ENS's treasury fight, the BonkDAO heist, and why Proph3t would not touch Venice's VVV token. ======================================================== Thank you to our sponsor! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Cape⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at cape.co/unchained (use code: UNCHAINED). ======================================================== Nick Johnson, the founder of ENS Labs, used his own tokens to kill a vote renewing ENS DAO's Security Council, potentially clearing the way for a foundation to take over a treasury worth more than $100 million. Nick Almond, head of governance at the Jito Foundation, and Proph3t, cofounder of MetaDAO, join Laura Shin to untangle what that move reveals about who should control a DAO's money, and whether voting was ever the right way to decide it. They trace ENS cofounder Jeff Lau's warning that the treasury became a honeypot with zero accountability, and the collapsing voter turnout that let a 3% token stake decide the DAO's fate. Proph3t makes the case for MetaDAO's decision markets over voting entirely, while Nick argues curated delegates solve the same capture problem without giving up the vote. They also cover the $20 million BonkDAO heist, pulled off with one proposal and seven votes, and the backlash over Dragonfly's investment in Venice's VVV token. Both guests agree DAOs are near a bottom. What comes next depends on whether anyone tries something new. Host: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Laura Shin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Host / Unchained Guests: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Nick Almond - Head of Governance at the Jito Foundation ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Proph3t - Co-founder of MetaDAO Timestamps

Christopher Nolan's The Odyssey arrives amid enormous anticipation. Jason considers whether the mythic epic can live up to the hype.A tribute to Sam Neill, who died this week, as we revisit a beautiful highlight from our archives: Neill reflecting on his favourite film - a clue, it was directed by Alfred Hitchcock.We speak with filmmaker Alain Gomis ahead of the Melbourne International Film Festival about Dao, his visually striking exploration of memory, history and identity; and MIFF Senior programmer Kate Jinx is in for a preview of this year's festival.Presenter, Jason Di RossoProducer, Sarah CorbettSound, Angie GrantArts editor, Sarah L'Estrange

Nick Almond and Proph3t on ENS's treasury fight, the BonkDAO heist, and why Proph3t would not touch Venice's VVV token. ======================================================== Thank you to our sponsor! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Cape⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at cape.co/unchained (use code: UNCHAINED). ======================================================== Nick Johnson, the founder of ENS Labs, used his own tokens to kill a vote renewing ENS DAO's Security Council, potentially clearing the way for a foundation to take over a treasury worth more than $100 million. Nick Almond, head of governance at the Jito Foundation, and Proph3t, cofounder of MetaDAO, join Laura Shin to untangle what that move reveals about who should control a DAO's money, and whether voting was ever the right way to decide it. They trace ENS cofounder Jeff Lau's warning that the treasury became a honeypot with zero accountability, and the collapsing voter turnout that let a 3% token stake decide the DAO's fate. Proph3t makes the case for MetaDAO's decision markets over voting entirely, while Nick argues curated delegates solve the same capture problem without giving up the vote. They also cover the $20 million BonkDAO heist, pulled off with one proposal and seven votes, and the backlash over Dragonfly's investment in Venice's VVV token. Both guests agree DAOs are near a bottom. What comes next depends on whether anyone tries something new. Host: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Laura Shin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Host / Unchained Guests: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Nick Almond - Head of Governance at the Jito Foundation ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Proph3t - Co-founder of MetaDAO Timestamps

Christopher Nolan's The Odyssey arrives amid enormous anticipation. Jason considers whether the mythic epic can live up to the hype.A tribute to Sam Neill, who died this week, as we revisit a beautiful highlight from our archives: Neill reflecting on his favourite film - a clue, it was directed by Alfred Hitchcock.We speak with filmmaker Alain Gomis ahead of the Melbourne International Film Festival about Dao, his visually striking exploration of memory, history and identity; and MIFF Senior programmer Kate Jinx is in for a preview of this year's festival.Presenter, Jason Di RossoProducer, Sarah CorbettSound, Angie GrantArts editor, Sarah L'Estrange

Il y a un siècle, le philosophe hindou Jinarajadasa, expliquait  : « Nous vivons aujourd'hui dans un monde devenu tragique. Ce qui normalement était circonscrit par les limites d'une nation est aujourd'hui ce qui caractérise le monde entier. C'est comme si la Terre tout entière avait reçu la secousse d'un violent tremblement de terre et que tout le monde soit étourdi, sans savoir quoi faire. Et cette tragique situation existe malgré le progrès général, tout spécialement dans le champ de la science. »Article de la revue Acropolis de mars 2024 par Fernand Schwarz, Philosophe, anthropologue, fondateur de Nouvelle Acropole en France. Lecture par Noëlle  Vannini.Abonnez-vous gratuitement à notre newsletter philosophique :www.revue-acropolis.comSaviez-vous que Nouvelle Acropole est réalisée à 100% par des bénévoles ? Nous dépendons donc beaucoup de nos étudiants et amis pour la divulgation !   N'oubliez pas de vous abonner à la chaîne et si possible de la partager sur vos réseaux sociaux.   Ce sera d'une grande aide !

This week on Chasin' The Racin' podcast, Josh and Christian are joined by Josh Brookes. We keep it relevant talking all things 2026 with a focus on his successful North West and TT as well as his season with DAO in BSB on the Honda and how that's going for him and the team. Josh doesn't hold back and let's us into his mindset during TT fortnight delays and challenges he's facing in BSB. Enjoy - CTR x   Powered by JCT Truck and Trailer Rental and WSC Performance       WSC Performance are a family run motorcycle performance parts company. Their business is based on passion and almost all of the parts they sell are stocked and in hand, unlike a lot of online stores of similar nature. Currently they offer brands including Brembo, EBC and SBS, eazi-grip tank grips, but the biggest part of their range is chain and sprocket kits, whether that's standard kits as direct replacement for your road bike, kits which allow you to customise your gearing or full race kits with a full range of sprockets and race chains. All orders include free shipping.       WSC Performance are totally online, so you can find them at www.wscperformance.co.uk or drop Simon an email at simon@wscperformance.co.uk if there's anything you can't find.       Episode Sponsor: AMR Motorcycles in Glasgow stocking a range of manufactures from Benelli to Lambretta, Sym, Voge and Benda + lots more. Check out their website to see there current new and used bikes for sale: https://amrmotorcyclesltd.com   We have many sponsorship options available and a brand new brochure for 2026 outlining all commercial opportunities  - please email chasintheracin@outlook.com if you're interested.       ------------               We have a full range of merchandise as well as Alan Carter's and Ian Simpson's Autobiography's over on our website: https://chasintheracin.myshopify.com               CTR Patreon Page: https://patreon.com/MotorbikePod?utm_...                 -------------                 SOCIALS:               Instagram: @chasintheracinpod               Facebook: Chasin' The Racin' Podcast               X: @motorbikepod

In this episode of Just DAO It!, host Adam Miller (CEO of MIDAO) sits down with Alex Soto (@alexsotodigital), a Mexico-based governance facilitator and author of "The Minimum Viable Institution: A Lightweight Coordination Model for DAOs and Purpose-Driven Networks."In the news report, they break down:The ENS DAO "2026 governance crisis" — treasury fights, resignations, and whether founder voting power amounts to a vetoThe Ethereum Foundation's major reorg, layoffs, and shift toward EthLabs and a multi-org ecosystemRegulatory updates: the U.S. CLARITY Act and its "ethics clause," Europe's MiCA deadline, USDT vs. USDC compliance, and evolving SEC decentralization rulesIn the interview, Alex shares his vision for the future of DAOs:Why good governance shouldn't require a benevolent founder — it should be designed to constrain powerThe critical difference between governance/meta-governance and day-to-day operationsSeparating capital from governance power ("raise money without giving power away")Role-based models, sociocracy, and holacracy as battle-tested alternatives to token votingWhy he doesn't believe in progressive decentralization — start small and decentralized, then growThe role of AI agents and smart contracts in maintaining coordination, accountability, and institutional memoryA wide-ranging conversation on coordination without subordination, capture resistance, and why "DAOs aren't dead — they haven't even arrived yet."Alex helps mission-driven organizations turn coordination challenges, disagreement, and distributed work into governance systems, shared practices, clearer decisions, and institutional learning loops.Find Alex: @alexsotodigital on all platforms | alexsotodigital.eth.limoFind MIDAO: @midaods | midao.orgDisclaimer: Not legal or tax advice.

Austin Griffith joins Kain Warwick and Taylor Monahan to unpack  BonkDAO's $20M governance heist, and Kain's case for giving founders more control. ======================================================== Thank you to our sponsors! ⁠⁠Cape⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at ⁠https://cape.co/unchained⁠ (use code: UNCHAINED). ======================================================== A single wallet spent $4.4 million buying up Bonk tokens, then used that stake to push through a governance proposal that legally emptied BonkDAO's roughly $20 million treasury a week later, with almost no one watching the vote. Austin Griffith, Ethereum Foundation developer and creator of Scaffold-ETH and founder of BuidlGuidl, joins Kain Warwick and Taylor Monahan to use the heist as a jumping-off point for Kain's real target: ENS. Kain argues founder Nick Johnson should retake control over building and product from the DAO, and makes the case that founder-led execution beats decentralized governance almost every time. They also cover Vitalik's Lean Ethereum overhaul and why Austin says it will barely change what he builds, the $1 AI audit he launched as a meme for x402 agent payments, Robinhood's new chain and the pay-to-play deals behind it, and why Kain now argues tokens are the wrong way to raise money. If a founder with total conviction can outperform a DAO built to stop exactly that, the DAO experiment may be further from finished than anyone wants to admit. Hosts: ⁠⁠Kain Warwick⁠⁠ - Host of Uneasy Money and Founder of Infinex and Synthetix ⁠⁠Taylor Monahan⁠⁠ - Co-host of Uneasy Money and Security Expert Guests: ⁠Austin Griffith - Ethereum Foundation developer and creator of Scaffold-ETH and SpeedRun Ethereum, and founder of BuidlGuidl Timestamps

令和7年度 査察の概要 https://www.nta.go.jp/information/release/kokuzeicho/2026/sasatsu/r07_sasatsu.pdf ーーーーーーーー

Austin Griffith joins Kain Warwick and Taylor Monahan to unpack  BonkDAO's $20M governance heist, and Kain's case for giving founders more control. ======================================================== Thank you to our sponsors! ⁠⁠Cape⁠: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at ⁠https://cape.co/unchained⁠ (use code: UNCHAINED). ======================================================== A single wallet spent $4.4 million buying up Bonk tokens, then used that stake to push through a governance proposal that legally emptied BonkDAO's roughly $20 million treasury a week later, with almost no one watching the vote. Austin Griffith, Ethereum Foundation developer and creator of Scaffold-ETH and founder of BuidlGuidl, joins Kain Warwick and Taylor Monahan to use the heist as a jumping-off point for Kain's real target: ENS. Kain argues founder Nick Johnson should retake control over building and product from the DAO, and makes the case that founder-led execution beats decentralized governance almost every time. They also cover Vitalik's Lean Ethereum overhaul and why Austin says it will barely change what he builds, the $1 AI audit he launched as a meme for x402 agent payments, Robinhood's new chain and the pay-to-play deals behind it, and why Kain now argues tokens are the wrong way to raise money. If a founder with total conviction can outperform a DAO built to stop exactly that, the DAO experiment may be further from finished than anyone wants to admit. Hosts: ⁠⁠Kain Warwick⁠⁠ - Host of Uneasy Money and Founder of Infinex and Synthetix ⁠⁠Taylor Monahan⁠⁠ - Co-host of Uneasy Money and Security Expert Guests: ⁠Austin Griffith - Ethereum Foundation developer and creator of Scaffold-ETH and SpeedRun Ethereum, and founder of BuidlGuidl Timestamps

Onchain analytics splits into two buckets: Research & Reporting (Dune dashboards, DeFi volume, DAO treasuries) and Risk & Compliance, which layers on attribution (naming wallet clusters) and risk scoring (sanctions, AML exposure) using tools like Chainalysis, TRM Labs, and Elliptic.This episode focuses on the Risk & Compliance side with Leopoldt Jansen Van Vuuren, Head of Onchain Analytics at Provenance, a compliance firm serving 400+ clients across 18 jurisdictions in VASPs, crypto funds, tokenised offerings, and DAOs.✅ OUR RESOURCES

In this episode, I sit down with Marko, Co-founder of Tapir Protocol, to break down one of the most underappreciated risks in DeFi , depegging. We dig into how stablecoins and yield-bearing assets can lose their peg, what the real financial damage looks like (spoiler: up to $3.3 billion in losses between 2020 and 2025), and how Tapir is building a smarter, fully automatic, non-custodial solution to protect investors without sacrificing yield or capital efficiency. Marko walks me through how Tapir splits a single asset into a depeg-protected version and a yield-boosted version, letting the market price the risk rather than a committee deciding your claim. Whether you manage a treasury, run a fund, or just want safer DeFi yields, this conversation is packed with practical insight. DisclaimerNothing mentioned in this podcast is investment advice and please do your own research. It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend. Be a guest on the podcast or contact us - https://www.web3pod.xyz/--- CONNECT ---Tapir Protocol Website: https://tapir.money/ Marko on Twitter/X: https://x.com/markoinether Tapir X/twitter: https://x.com/Tapir_Protocol--- KEY POINTS WITH TIMESTAMPS ---• [00:00] Sam introduces Marko from Tapir Protocol and the focus on safer DeFi for institutional and retail investors• [01:19] Marko shares his background , from e-commerce to crypto in 2015, winning ETH Global hackathons in 2020 and 2021, building Marinate Finance (first liquid staking on Solana), and leading developer ecosystems at SSV Network• [04:15] Discussion on the explosive growth of stablecoins and why stablecoin yield products are the focus for Tapir• [07:02] Deep dive into what a depeg is and a live case study of APX USD trading at 80 cents on the dollar• [08:48] How Tapir splits one asset into three: a base version, a depeg-protected version, and a yield-boosted version , all 100% capital efficient• [13:02] Tapir's business model , a marketplace that earns a small fee on minting and redeeming assets• [13:59] Where Tapir is in its lifecycle , live on mainnet, running with internal funds, opening to launch partners and private mainnet users very soon• [16:05] Who Tapir is built for , DAO treasuries, fund managers, and any DeFi investor who understands that risk is real• [19:07] Sam and Marko discuss the drop in DeFi TVL from $180B to ~$69B and how AI-assisted bug finding is increasing vulnerability concerns• [21:23] Tapir has completed two independent audits and keeps its entire codebase under 1,000 lines of code to minimise attack surface• [24:36] Marko's take on algorithmic stablecoins , most fail because of positive feedback loops that collapse under stress• [26:22] Breakdown of Tapir's depeg analysis: long-term depeg losses estimated at $1.5B to $3.3B between 2020 and 2025• [30:46] How Tapir differentiates from Nexus Mutual, Y2K Finance, and other risk protection protocols , fully automatic resolution, no claims committees, and no capital inefficiency• [39:48] Will USD-denominated stablecoins keep dominating? Marko shares his view and gives a shoutout to Vifi (Virtual Finance) building for smaller currencies• [44:00] What's next for Tapir , opening to external users, launching higher-yield pools targeting ~15%, and looking for feedback from funds on which assets to list next

As acupuncture and Chinese medicine face regulatory pressure and institutional change on both sides of the Atlantic, many practitioners are asking what it takes to preserve the tradition while still being taken seriously as medical professionals.In this conversation, we visit with Alex Jacobs, CEO of the British Acupuncture Council, we explore the relationship between tradition and regulation, and how this balance shapes education standards, professional identity, and public trust in the medicine.We also discuss the value of holding contradiction in clinical practice, the difference between the "disciple" and the "heretic" as two complementary ways of learning, and the deeper role of listening and the heart in diagnosis.Listen in for a discussion on regulation, lineage, and mastery, and staying rooted in the Dao of the medicine while navigating the demands of practicing it today.

For episode 258 of the Crypto Altruists podcast, we're excited to welcome Shannon Lanigan, Heenal Rajani, and Marvin Paul of All In For Sport, a decentralized autonomous organization (DAO) on a mission to create a “coordi-nation” to support projects that advance inclusion and empowerment through sport.This episode is part two of an ongoing conversation, so let me set the stage. In episode 245, we sat down with the team at SuperBenefit to explore their Reimagining Power series. That conversation was about the theory and the possibilities: how Web3 could be a tool for systems change, how we might redistribute power rather than concentrate it, and how we can confront the uncomfortable history of development work and philanthropy instead of repeating its mistakes in Web3.It was a rich, thought-provoking discussion. But it lived mostly in the realm of ideas. Today, we get to see those ideas put into practice with a case study, a real-world test of what we discussed in that first conversation. We highlight All In For Sport's collaboration with Sarreya, an organization that has spent over a decade creating space for women and girls to play sport in Somaliland.The project, The Six-Month Wire Transfer (And What We're Doing About It), is named after a very real experience: a routine grant payment that took six months to reach Sarreya, blocked, rerouted, and questioned every step of the way. And it grew into something much bigger than a payments experiment. It became a test of whether Web3 tools could not only move money to a community the traditional financial system overlooks, but also shift power, introducing governance structures and transparent treasury management that keep decision-making in the hands of the community itself.In today's discussion you'll learn:⚽ How All In For Sport and Sarreya are leveraging crypto to support women and girls playing sport in Somaliland

You're eating healthy foods, choosing fermented products, leftovers, tomatoes, or avocado—yet your migraines seem to keep showing up. Could histamine be part of the puzzle?In this episode of Migraine Heroes Podcast, host Diane Ducarme explores the surprising connection between histamine sensitivity and migraines. Discover why foods that are considered healthy for many people can sometimes become hidden triggers for a sensitive nervous system.You'll discover:

El régimen de la Guardia Civil establece la suspensión del DAO tras ser imputado y tiene que decidirlo Margarita Robles.

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! El régimen de la Guardia Civil establece  la suspensión del DAO tras ser imputado y tiene que decidirlo Margarita Robles. Escucha este episodio completo y accede a todo el contenido exclusivo de Javier Cárdenas - Levántate y Cárdenas. Descubre antes que nadie los nuevos episodios, y participa en la comunidad exclusiva de oyentes en https://go.ivoox.com/sq/1482749

El equipo de La Trinchera repasa la información semanal centrada en el pacto de Andalucía y la imputación de la Directora y el DAO de la Guardia Civil

Nick Johnson's ENS vote sparked days of backlash. He and co-founder Alex Van de Sande join Uneasy Money to explain what actually happened. ======================================================== Thank you to our sponsors! ⁠Cape: Your biggest crypto vulnerability isn't your wallet, it's your phone number. Cape is America's privacy-first mobile carrier that rotates your SIM identity daily and blocks SIM swaps before they happen. Get 33% off your first six months at ⁠https://cape.co/unchained⁠ (use code: UNCHAINED). ======================================================== A routine two year renewal for the ENS DAO's Security Council failed on chain this week, and Nick Johnson, founder and CEO of ENS Labs, voted against it with roughly 50% of the active supply. Some users on X have since cast him as the villain seizing a $130 million treasury. ENS co-founders Nick Johnson and Alex Van de Sande join Kain Warwick and Taylor Monahan to untangle what the vote means, and to defend a new proposal handing day-to-day treasury and protocol decisions to a foundation instead of the DAO. They trace how ENS's governance fight mirrors Aave's, why its treasury has trailed a savings account, why Johnson never trusted ETH-weighted voting, and why his conviction in token governance has weakened. The conversation lands on the question hanging over every well-funded DAO: once a protocol accumulates enough money to matter, can any voting mechanism decide who controls it? Hosts: ⁠Kain Warwick⁠ - Host of Uneasy Money and Founder of Infinex and Synthetix ⁠Taylor Monahan⁠ - Co-host of Uneasy Money and Security Expert Guests: Nick Johnson - Founder and CEO of ENS Labs Alex Van de Sande - Cofounder of ENS Timestamps

Por Yaiza SantosDespués de leer el retrato redondo que Juan Abreu le ha hecho a Miriam Nogueras, bajó allá donde la política no es tan agradable como en los libros de su amigo. Y dijo: la imputación de la directora de la Guardia Civil y el llamado DAO por parte del juez Pedraz necesariamente ha de llevar un auto de procesamiento. Abrir en canal al Estado con indicios frágiles tendría, consideró, graves consecuencias.El señor Moreno ha nombrado vicepresidente al portavoz de Vox, y de esa decisión no puede desprenderse más que uno no puede ir diciendo bobadas, como eso de la vía autónoma y otras inefables ideas que, le cuenta Landaluce, se incluyen en Manual de convivencia. También es un mensaje para Feijóo.Abandone el líder de la oposición –dictó– cualquier veleidad con Junts ¡e incluso con el Partido Socialista! El discurso del PP debe ser, ya lo dijo, el del repudio. El señor Feijóo debe dirigirse a los españoles con total naturalidad, proponiéndoles un contrato moral, más que electoral. "Miren, estos son tiempos excepcionales y hay que asumirlos; voten ustedes lo que quieran, pero no a Sánchez, y ya veremos".Se detuvo en un hallazgo extraordinario: la posibilidad de que los medicamentos tipo Ozempic, además de combatir la diabetes, la obesidad y algunas adicciones, sirvan también para reducir los crímenes violentos, al actuar en la pequeñísima franja entre el impulso y la acción. Solamente interviniendo en la intimidad de esos mecanismos se puede tener éxito, consideró. Y si el periodismo fuera lo que tiene que ser, la noticia habría abierto las primeras planas de todos los periódicos.Siendo la fecha que es, tararearon canciones del verano, y Santos culminó des pa ci to.Y fue así que Espada yiró.Bibliografía:- Juan Abreu, Eros y política.- Modelos animales para salvar vidas humanas, Fundación Séneca-Universidad de Murcia.- BSO 1.- BSO 2.- BSO 3.- BSO 4.- BSO 5.- BSO 6. - BSO 7. Hosted on Acast. See acast.com/privacy for more information.

The crew is joined by Selini Capital's Jordi Alexander to break down Open USD, the no-fee stablecoin from a 140-firm consortium spanning Visa, Mastercard, BlackRock, Google and Coinbase, all aimed at the Circle and Tether duopoly. Plus Saylor's new Digital Credit framework for MicroStrategy, the Ansem-fueled memecoin comeback, and ENS reigniting the “DAOs are fake” debate. Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. Joining the panel “at the moment of max pain” is Jordi Alexander, CIO of Selini Capital. First up: MicroStrategy in crisis, with MSTR down about 30% in five days and STRC hitting $71, and Saylor's answer, a new Digital Credit framework with an 18-month cash cushion and a jumbo dividend hike to 12%. Then the headline story, Open USD: a no-fee stablecoin from a 140-member consortium including Visa, Mastercard, BlackRock, Google and Coinbase, built to break the Circle and Tether duopoly. The back half covers the memecoin comeback around the Ansem coin, and ENS reigniting the “DAOs are fake” debate after Nick Johnson single-handedly blocked a governance vote, before the crew debates whether consortia are just DAOs in a suit. Let's get into it. Listen to the episode on Apple Podcasts, Spotify, Pods, Fountain, Podcast Addict, Pocket Casts, Amazon Music, or on your favorite podcast platform. Show highlights

Latorre sobre la imputación del DAO y la directora de la Guardia Civil: "Lo grave ya no es que estén siendo investigados, sino que al Gobierno le da igual"

Juan Pablo Polvorinos repasa la actualidad centrada en la imputación de la directora de la Guardia Civil y al DAO en el caso cloacas.

This episode is a replay from The Existential Stoic library. Enjoy! What is the Daoist concept of wu-wei? Is wu-wei similar to any concepts from Western philosophy? In this episode, Danny and Randy discuss the Daoist concept of wu-wei or effortless action.Subscribe to ESP's YouTube Channel! Thanks for listening!  Do you have a question you want answered in a future episode? If so, send your question to: existentialstoic@protonmail.com

In this episode Dr. Jockers explains the truth about histamine intolerance and how it connects to allergies, headaches, rashes, and chronic inflammation. You will learn why histamine is an essential immune and nervous system messenger that becomes problematic when the body can't clear it efficiently. This episode explores the early warning signs and what they actually mean for your health.   You will discover how histamine overload develops when gut health, liver function, and key enzymes like DAO and HNMT are compromised. The discussion breaks down why common symptoms like fatigue, hives, migraines, and skin reactions often trace back to this imbalance. You will also understand how internal stressors amplify histamine response in ways most people overlook.   You will also learn the hidden drivers behind histamine intolerance including gut infections, nutrient deficiencies, and everyday medications that interfere with detox pathways. Dr. Jockers outlines how food choices, stress, and environmental exposures all contribute to the overall histamine load. You will come away with a clearer understanding of how to restore balance and support long-term resilience. In This Episode:  00:00 Histamine Overload Symptoms 00:20 Podcast Intro and Coaching 04:00 Histamine Basics and Enzymes 06:37 Root Causes Gut Liver Nutrients 10:04 Medications That Worsen Histamine 13:22 Histamine Rich Foods Explained 15:37 Natural Fix Stress Toxins Liver 17:36 Gut Immune Support Supplements 20:17 Wrap Up and Next Steps Struggling with bloating, cravings, or blood sugar swings often comes down to poor digestive and metabolic support. This Apple Cider Vinegar Complex delivers the benefits of ACV without the harsh taste, plus added turmeric, ginger, Ceylon cinnamon, and lemon for enhanced gut and energy support. Go to paleovalley.com/jockers and save 15% off today   Caffeine crashes and nicotine dependence can quietly sabotage your focus, mood, and all-day energy. Ultra Pouches are engineered with clinically studied nootropics like L-theanine, Alpha-GPC, and active B vitamins to deliver clean, steady mental clarity without stimulants or jitters. Head to takeultra.com, use code JOCKERS, and get 15% off today   "Common histamine triggers include leftovers, fermented foods, bone broth, vinegar, and certain fruits like bananas, avocados, and strawberries." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit paleovalley.com/jockers and save 15% off today Head to takeultra.com, use code JOCKERS, and get 15% off today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Dismantling the illusion of separation, Alan Watts shares how recognizing our fundamental unity with the universe transforms the way we live, perceive, and prepare for death.Help us celebrate 10 years of Be Here Now Network and support the next chapter of Ram Dass Here and Now. Gifts are matched dollar for dollar through June 30. Learn more and give here: BHNN 10th Birthday FundraiserToday's episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/alan and get on your way to being your best self.This week on Being in the Way, Alan Watts lectures on:Playing hide and seek with our true selvesHow your body knows that you are one with the universeSeeing things versus noticing thingsThe yoga of preparing for death The partial view that the ego keeps us trapped in The continuous energy of our bodiesDissolving the distinction between voluntary and involuntary behavior The transaction between the individual and the world This series is brought to you by the Alan Watts Organization and Ram Dass' Love Serve Remember Foundation. Visit Alanwatts.org for full talks from Alan Watts. “Doesn't it really astonish you that you are this fantastically complex thing and that you're doing all of this and you never had any education in how to do it? You never learned, but you're this miracle. From a strictly physical, scientific standpoint, this organism is a continuous energy with everything else that's going on. If I am my foot, I am the sun. Only, we've got this little partial view. We've got the idea that ‘I'm just something in this body', the ego, that's a joke.” –Alan WattsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Just DAO It | Ep. 2 — Kenny from poidh.xyz on Bounties, DAOs & AI AgentsAdam Miller (CEO of MIDAO) sits down with Kenny, founder of Pics or It Didn't Happen (poidh) — a permissionless bounty protocol the enables "ephemeral DAOs.” They break down the biggest crypto hacks of the past few months, the state of crypto regulation in the US and Europe, the reality of AI agents transacting on-chain, and why Kenny thinks the DAO model has been wrong from the start.Chapters:0:00 — Intro & Welcome Back (first episode in over a year!)1:55 — News: Record-Breaking Crypto Hack Month ($600M+ lost in April)5:42 — The Kelp/LayerZero Attack Explained13:21 — The Trapdoor Campaign: AI Agents as Attack Vectors17:21 — US Crypto Regulation: Genius Act, Clarity Act & Open Source Immunity22:13 — MiCA in Europe: 85% of Firms Without a License28:04 — 400K AI Agents On-Chain: Impressive or Just Testing?37:16 — Interview: Kenny's Background & How He Got Into Crypto44:07 — Deep Dive: What Is POIDH and How Does It Work?48:05 — A Brief History of DAOs and Why They Failed56:00 — The "Atomic Unit" of a DAO: Objectives, Not Organizations1:03:24 — Progressive Decentralization & Token Strategy1:07:04 — Working With DAOs: The Haberdashery & Breaking a Kickflip World Record1:13:35 — Pump.fun Launches Bounties: What It Means for POIDH1:16:19 — The Big Vision: Online Communities Pooling Capital IRL1:16:47 — Where to Find Kenny & POIDHLinks:* poidh: poidh.xyz* MIDAO: midao.org* Beta Briefing (AI news agent): betabriefing.ai* Kenny on X/Twitter: @KennyIsTyping | Farcaster: @Kenny* Adam on X/Twitter: @0xThriller | Farcaster: @TheThrillerNot legal or financial advice.

In this episode, I'm sharing a reflection on Wu Wei, a Taoist principle often translated as "effortless action" or "action without force," and why this ancient wisdom has landed so deeply for me in this current season of life.For years, my business moved with a rhythm I had come to trust. Coaching spots filled, programs attracted people with ease, and opportunities seemed to flow naturally. But this year has looked very different. For the first time in a long time, coaching enquiries have slowed right down, and a program that has comfortably filled for years now has only a handful of participants.This season has challenged me in ways I didn't expect. It has brought up questions about trust, identity, worth, and what happens when the external validation we've become accustomed to begins to quieten down. Rather than immediately looking for another strategy, another offer, or another way to make things happen, I've found myself sitting with a different question altogether: What if nothing has gone wrong?In this conversation, I explore how quickly we can move into fixing, forcing, controlling, and solving when life doesn't unfold the way we expect it to. I share how Wu Wei has invited me to consider a different approach. One that isn't passive or detached, but one that asks us to stop exhausting ourselves by pushing against reality and instead learn how to move with life rather than against it.I also reflect on something I've been thinking deeply about lately. For many years, my work has been about helping people come home to themselves, uncover their conditioning, recognise the ego, and reconnect with who they truly are. But what if authenticity isn't the destination? What if it's only the beginning?Because once we know who we are, life asks us a new question: Can we trust that person? Can we trust ourselves when the future is uncertain? Can we trust ourselves when the evidence isn't there? Can we trust ourselves when life isn't unfolding according to our plans?This episode is a vulnerable reflection on what it means to stay open when certainty disappears, to loosen our grip on outcomes, and to trust that life may be leading us somewhere we never would have chosen for ourselves.If you've ever found yourself in a season where the old ways no longer seem to work, where you're questioning what comes next, or where life is asking you to trust more deeply than ever before, I think you'll find something for yourself in this conversation.In this episode, I explore Wu Wei and effortless action, trusting life through uncertain seasons, navigating change in business and identity, authenticity beyond self-discovery, releasing attachment to outcomes, and learning how to meet life as it is rather than constantly trying to make it something else.My hope is that this episode reminds you that not every season is meant to be conquered. Some seasons are meant to be listened to.Support the show

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

On the Evolving Wellness podcast, host Sarah Kleiner interviews returning guest Steve about seasonal allergies, histamine intolerance, and MCAS, emphasizing that the root problem is often loss of immune tolerance driven by gut dysbiosis, leaky gut, and Th1/Th2 imbalance from factors like antibiotics, PPIs, stress, mold, and environmental changes. They contrast symptom tools—antihistamines that block histamine receptors and herbs like quercetin/ginger that stabilize mast cells—with approaches aimed at lowering IgE formation and retraining gut–immune “crosstalk.” Steve describes postbiotics and beta-glucans as “tolerization rehab,” highlighting his product HoloImmune (heat-killed strains) and butyrate (TriButyrin-X) for gut lining and mast cell support, plus DAO enzymes for dietary histamine. They discuss safety, dosing, avoiding live probiotics during flares, and examples including motion sickness, bug-bite welts, and a child's post-viral hives.— GUT HEALTH:  Healthy Gut Supplements- discount automatically applied: Holoimmune: https://healthygut.com/holoimmune-now/?rstr=811&coupon_code=Sarah15 Holozyme Link: https://healthygut.com/holozyme-now/?rstr=811&coupon_code=Sarah15 HCL Guard Link: https://healthygut.com/hcl-guard-now/?rstr=811&coupon_code=Sarah15 Tributyrin X: https://healthygut.com/tributyrin-x-now/?rstr=811&coupon_code=Sarah15 Magnesium: https://healthygut.com/magnesiumhp-now/?rstr=811&coupon_code=Sarah15 _________Sponsored By:→ VivaRays | This episode is sponsored by VivaRays - VivaRays Blue - code YOGI https://vivarays.com/→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide._________Timestamp:00:00 Coming Up01:02 Podcast Intro Disclaimer02:15 Spring Allergies Setup05:05 Loss Of Tolerance08:02 Why Symptoms Worsen10:25 How Antihistamines Work11:59 Mast Cell Stabilizers14:20 Rewiring With Postbiotics16:20 Red Light Sponsor Break17:59 MCAS Pepcid Bridge22:11 Gut Healing Without Probiotics25:45 Blue Blockers Sponsor Break27:12 Mold And Individual Variance29:57 Antibiotics Farm Effect31:39 Dead Bugs Vs Probiotics32:40 Live vs Dead Probiotics33:25 Immune Software Updates35:28 Strawberry Hives Story36:40 Allergy Medicine Toolkit37:25 DAO Enzyme Explained40:05 Springtime Support Stack40:48 Root Causes and Triggers42:38 Immune Rehab and Tolerance45:56 How to Start Dosing49:11 Coaching Over AI51:47 Antihistamines and Acid Blockers53:56 How Long to Take It56:35 Leaky Gut and Butyrate57:39 Hidden Histamine Symptoms58:29 Motion Sickness and Bug Welts01:00:17 Wrap Up and Resources——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Have you done all the right things and still spent two weeks a month feeling like a completely different, much less pleasant person? I get it.Most PMS and PMDD conversations stop at estrogen and progesterone. But if you're still dealing with mood swings, brain fog, or symptoms that show up around ovulation, too, there's a piece nobody's named for you yet. It's histamine. And before you say, "I don't have allergies" - that's not what we're talking about here. In this episode, I'm walking you through why histamine can be a very real driver of your hormonal symptoms, why it tends to spike at two specific points in your cycle, and what's actually going on underneath that your body has been trying to flag.You'll learn:The estrogen-histamine feedback loop that makes symptoms spike at two points in your cycle, including mid-cycle, when you're supposed to feel goodThe specific signs that point to histamine as a contributing factor in your PMS/ PMDD Why supplements like DAO enzyme or Quercetin can help temporarily, and what the real question is that nobody's askingIf histamine has never once crossed your mind as a reason you feel terrible two weeks out of the month - buckle up, because this episode is about to make a lot of things click.And if you're currently tracking your basal body temperatures and your PMS is still not where you want it to be, I have something for a few of you at the end of this episode. Stay all the way through, you'll want to hear it.Breakfast GuideNourish Tracker - Discount code: HAPPILYHORMONALBook a FREE Hormone Strategy Call with meGrab your Happily Hormonal Quick Start GuideNEED HELP FIXING YOUR HORMONES?Hormone Imbalance Quiz - Find out which of the top 3 hormone imbalances affects you most!Join Nourish Your Hormones Coaching for the step-by-step and my eyes on YOUR hormones for the next 4 monthsSend us a text with episode feedback or ideas! (We can't respond to texts unless you include contact info but always read them)Don't forget to subscribe, share this episode, and leave a review. Your support helps us reach more women looking for answers.Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.This podcast is for women and moms to learn how to balance hormones naturally in motherhood, to have pain-free periods, increased fertility, to decrease PMS mood swings, and to increase energy without restrictive diet plans. You'll learn how to balance blood sugar, increase progesterone naturally, understand the root cause of estrogen dominance, irregular periods, PCOS, insulin resistance, hormonal acne, post birth-control syndrome, and conceive naturally. We use a pro-metabolic, whole food, root cause approach to functional women's health and focus on truly holistic health and mind-body connection.If you listen to any of the following shows, we're sure you'll like ours too! Pursuit of Wellness with Mari Llewellyn, Culture Apothecary with Alex Clark, Found My Fitness with Rhonda Patrick, Just Ingredients Podcast, Wellness Mama, The Dr Josh Axe Show, Are You Menstrual Podcast, The Model Health Show, Grounded Wellness By Primally Pure, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, Simple Farmhouse Life with Lisa Bass

Nick Almond of the Jito Foundation joins David to walk through why DAO governance is a mess, what “pragmatic decentralization” looks like in practice, and how the CLARITY Act will reshape governance going forward. Enjoy! TIMESTAMPS: (00:00) Intro (01:22) Why Governance Matters (03:43) Token Voting (05:12) Delegates and Multisigs (08:56) Nexo Ad (09:30) Sub-DAOs and Specialization (11:33) Governance Tokens Origins (15:47) Pragmatic Decentralization (18:22) Cosmetic Votes and Value (20:37) Nexo Ad (21:35) Arbitrum Governance (25:59) Regulation and CLARITY (29:11) Bitcoin Governance Lessons (34:03) Meta Governance and Agility (36:48) Tokens as Equity Future (39:41) Closing Thoughts FOLLOW THE SHOW › David — https://x.com/dcanellis › The Breakdown — https://x.com/TheBreakdownBW › Nick Almond — https://x.com/DrNickA › Jito Foundation — https://x.com/jito_sol SPONSORS › NEXO Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/ DISCLAIMER As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Moving beyond the imagined boundary of form, Alan Watts explores the idea that humanity is a microcosm of the universe and that the two are inseparable. Today's episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/alan and get on your way to being your best self.This time on Being in the Way, Alan Watts discusses:Considering whether being part of a whole means that we are the wholeThe radial structure of humanity, Earth, and all beingsRecognizing that skin is not the boundary of manHow foreign the inner workings of the human body seem to humannessThe nature of the mind, likened to the nature of spaceThe illusion of an individual operating from himself Blending together materialism and mysticism, not getting too stuck in one or the other This series is brought to you by the Alan Watts Organization and Ram Dass' Love Serve Remember Foundation. Visit Alanwatts.org for full talks from Alan Watts. “Any other way of looking at things is kind of schizoid. It looks at human beings as if they arrived in this world like a bunch of birds on the branches of a barren tree. They just got settled there, they don't belong, a sense of being strangers and pilgrims from another domain altogether. Well, where is this other domain, and how does it relate to this one?” –Alan WattsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Missiles in the Strait of Hormuz. Brent jumps 5%. Bitcoin breaks through $80. The Bits + Bips crew reads the geopolitical tape — and explains why crypto is shrugging it off. --- Thank you to our sponsor! Coinbase One — coinbase.com/unchained Heads up! If you haven't yet, be sure to subscribe to Bits + Bips, since the show will migrate there in a few weeks. Follow us on ⁠⁠⁠⁠Apple Podcasts⁠⁠⁠⁠, ⁠⁠⁠⁠YouTube⁠⁠⁠⁠, ⁠⁠⁠⁠Spotify⁠⁠⁠⁠, ⁠⁠⁠⁠X⁠⁠⁠⁠, ⁠⁠⁠⁠Unchained⁠⁠⁠⁠ and wherever you get your podcasts. ---- Iranian cruise missiles struck commercial vessels in the Strait of Hormuz, Brent jumped 5%, and Bitcoin broke through $80 — all in the same day. The Bits + Bips crew unpacks what the escalation means for crypto and macro positioning, why Ram stays bullish, and whether Paul Tudor Jones is right that Bitcoin is now the best inflation hedge. They also break down the Clarity Act's yield compromise — with Circle up 16% — and why Austin argues banks may have handed asset managers a structural win. Finally, a U.S. court filing targeting Arbitrum's frozen North Korean funds raises a bigger question: can you serve legal papers on code, and what does that mean for DAO governance? Austin Campbell, Ram Ahluwalia, and Chris Perkins break it all down. Hosts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Austin Campbell (@austincampbell) — Founder, Zero Knowledge Consulting; Adjunct Professor, NYU Stern ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ram Ahluwalia⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Co-Host, CEO of Lumida ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Chris Perkins⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, Co-Host, CEO of 250 Digital Asset Management Learn more about your ad choices. Visit megaphone.fm/adchoices