Podcasts about melanopsin

In this episode, we navigate the fascinating world of circadian rhythms and their profound impact on our health. We cover essential biology and protocols for human health, Autism or not. We will discuss how these natural cycles of light and dark regulate our biology, from hormone production to mood and cellular function, and why disruptions—particularly from artificial light—are a growing concern in modern society. Highlighting the role of melanopsin, a blue light-absorbing protein discovered as recently as 1998, we explore how exposure to LED and tech light can throw off our internal clocks, a challenge especially relevant for those with autism who often struggle with circadian rhythm issues.Modern life has two problems: 1) removing ourselves from the full sun spectrum and 2) extending the day with artificial light at night. This, in large part, explains the origins of Autism: 1) a lack of biological energy (energy from the full sun spectrum during development- remember the episodes on neurulation, embryo and womb) and 2) improper clock-timing in our biology (in large part, this is why the gastrointestinal comorbid problem is heavily involved with Autism).We also introduce actionable protocols to reset and maintain a healthy circadian rhythm, whether you're autistic or not, emphasizing the critical role of sunlight at different times of day—morning, midday, and evening. We will discuss innovative solutions like the Daylight Computer, a blue light-free, flicker-free device designed with sensory-sensitive users in mind, and Chroma light devices that harness specific wavelengths to enhance well-being. Alongside these insights, we touch on historical and environmental factors, including a thought-provoking comparison to the Amish lifestyle, to underscore how our modern world might be influencing Autism rates and overall health.use "autism" for $25 off athttps://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Circadian rhythms introduced; blue light's impact via melanopsin and Daylight Computer's benefits.00:42 Daylight Computer Company5:00 Blue light's harm, autism energy deficits, and artificial vs. natural light comparison.08:01 Melanopsin's role, modern light's disruption, and historical autism link to artificial light.12:01 Amish lifestyle comparison and modern environments' effect on autism rates.16:01 Morning sunlight protocol for circadian reset via SCN and melatonin timing.20:01 Morning sun primacy; Non-Negotiable 21:23 Chroma light devices for health24:33 Midday sun / UV light for longevity, evening sun's role, and ranking sunlight importance.28:01 Nighttime light management: avoid overhead lights, prefer candles/red lights, ensure dark sleep.32:01 Maternal health benefits, reviews/ratings, and social media/podcast engagementX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For today's episode, we discuss Autism and sensory processing. The episode expands on the concept of the mesencephalon (midbrain), touching on the superior and inferior colliculi, key regions that help extract and integrate sensory information. The role of melanin in sensory processing is highlighted, as it aids in signal transfer and increases efficiency in sensory organs, including the eyes, ears, and skin. The episode also connects these concepts to autism, noting that individuals with Autism often experience both hypersensitivity and hyposensitivity to sensory stimuli, affecting their interaction with the environment.The episode also dives into the biological foundations of sensory perception, focusing on the role of melanopsin and other chromophores in light absorption and how they influence wakefulness and sleep cycles. Additionally, we cover the auditory system, specifically how melanin in the cochlea contributes to hearing and how auditory processing can become overwhelmed in individuals with Autism, leading to sensory overload. The discussion then extends to the role of melanin in other systems, such as the gastrointestinal tract, and its connection to energy production and sensory perception. By exploring the pathophysiology of Autism at an early developmental stage, the episode emphasizes the need to investigate sensory processing and its integration across the nervous system to better understand Autism.Role of semiconductivity and ion transport in the electrical conduction of melanin https://pmc.ncbi.nlm.nih.gov/articles/PMC3384144/Dr. Jack Kruse: QUANTUM ENGINEERING #53: WHY IS MELANIN ALWAYS FOUND BETWEEN YOUR SENSES & THE ENVIRONMENT? https://www.patreon.com/posts/quantum-53-why-83720421Dr. Jack Kruse: QUANTUM ENGINEERING #45: AUTISM & MELANIN/MELANOPSIN: A MIGRATION PROBLEM https://www.patreon.com/c/DrJackKruse/posts00:00 Autism and Sensory Processing02:31 Mesencephalon's Role; Melanopsin; Chromophores05:02 Melanin in Sensory Systems07:33 Light and Quantum Biology10:04 Environmental Impact on Health; Hypo and Hypersensitivity12:35 Energy and Mitochondria15:06 Embryogenesis and Autism Origins; Neuralation, Neuroepithelial Cells17:37 Autism Research19:05 Reviews/Ratings & Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss the connections between autism and eye movements, starting with the underappreciated role of eyes in human biology. We emphasize the significance of the retina, which is central to both image-forming and non-image-forming functions of vision. The discussion takes a turn towards how blind individuals also leverage their eyes for biological functions beyond sight, highlighting the pervasive influence of visual systems on human physiology. We explore the superior colliculus, an essential brain region that integrates sensory information from various sources, including vision, to direct our attention and reflexive responses. This area is crucial in understanding how sensory input differently, particularly in terms of attention bias and threat detection, which could explain some of the unique sensory experiences in Autism.We then touch upon the dorsal anterior cingulate cortex (dACC) and the roles in error detection, conflict monitoring, and effort evaluation. The dACC's involvement in these cognitive processes can provide insights into why certain social cues or environmental stimuli might be overwhelming or less salient for individuals on the spectrum. Additionally, the episode covers oxytocin, a hormone/neuropeptide involved in social bonding and emotional regulation, discussing its synthesis through magnocellular and parvocellular pathways in vision. What do you think oxytocin is doing here, for the cub and for you? https://www.reddit.com/r/NatureIsFuckingLit/comments/11q03yn/a_cub_puma_admiring_his_mother/?rdt=64743Eye-Tracking as an Early Biomarker of Autism https://youtu.be/fJpIRHOZZO4The Roles of Oxytocin and Vasopressin in the Autistic phenotype https://youtu.be/DAtmC-s1_e0Mesencephalon https://en.wikipedia.org/wiki/Midbrain#:~:text=The%20midbrain%20or%20mesencephalon%20is,view%20of%20one%20cerebellar%20hemisphere.00:00 - Introduction to Autism and Eye Movements; importance of eyes in biology, specifically mentioning the retina as a key player.04:19 - Non-Image Functions and Master Clock; Melanopsin; SCN- master clock08:13 - Eye Tracking and Autism Diagnosis; effectiveness at 14 months of age12:23 - Biological Underpinnings of Eye Movements in Autism; dorsal anterior cingulate cortex (dACC), Superior Colliculus & Mesencephalon & sensory integration, attention in the context of Autism & brain development16:48 - Sensory Integration & Superior Colliculus and Reflexive Responses & Biasing Attention.20:58 - Developmental Aspects of Autism; embryonic stage before the central nervous system25:11 - Vision and Autonomic Nervous Systemvision and breathing can influence stress and calmness & bidirectional connections27:47 Reviews/Ratings and Contact InformationX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Autism just magically shows up.In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics."... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uATetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMITetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXsTryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079revAutism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567Regions of Interest:Atoms,Aromatic Amino Acids,Artificial Light,Chromophores,Cytochromes,Electromagnetic,Embryo,Folate Acid (and Folic Acid)Sunlight,Melanin (Neuromelanin),Melanocytes,Melanogenesis,Melanopsin,Mitochondria,Neuroectoderm,Neuroplasticity,Periodic Elements,Photoelectric Effect,Pro-opiomelanocortin (POMC)Proteins (wide-band gap semiconductors),Serotonin,Tryptophan Hydroxylase 1 and 2,Vitamins A, b9 (Folate/Folic Acids), B12, and D,WaterX: https://twitter.com/rps47586YTEmail: info.fromthespectrum@gmail.com

Dr. Roger Seheult is a world leading medical educator and practicing Intensive Care physician from  California, USA also board-certified in respiratory, sleep and internal medicine. He is the founder of the Medcram YouTube channel and has recently been the use of heliotherapy for patients with acute viral respiratory infections.We discuss the importance of circadian rhyhtms, how infrared light is interacting with life, mitochondria and disease, problems of artificial light at nigth and the indoor environment, how to educate people on light as medicine and much much more.LEARN about Light & Health with me....

In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process. A valuable consideration is the roles our eyes have on brain development, which we cover as well. Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/careRudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e00:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin and Choroid Plexus 7:06 Melanin and Melanopsin through the body and biochemistry8:39 Fruit Tree Example from Dr. Kruse9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following 17:21 Gaze Attention 18:02 Joint Attention 19:12 Studies on Infants; Pierce et al, 201925:00 Wen et al, 202227:03 Keehn et al, 2024 and Early Autism Evaluations (EAE) 29:25 Rudling et al, 202432:15 Wrap-Up/Final Thoughts34:55 Reviews/Ratings, Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

It's our annual updates episode! Thanks to Kelsey and Torin for the extra information about ultraviolet light, and thanks to Caleb for suggesting we learn more about the dingo! Further reading: At Least 125 Species of Mammals Glow under Ultraviolet Light, New Study Reveals DNA has revealed the origin of this giant ‘mystery' gecko Bootlace Worm: Earth's Longest Animal Produces Powerful Toxin Non-stop flight: 4,200 km transatlantic flight of the Painted Lady butterfly mapped Gigantopithecus Went Extinct between 295,000 and 215,000 Years Ago, New Study Says First-Ever Terror Bird Footprints Discovered Last surviving woolly mammoths were inbred but not doomed to extinction Australian Dingoes Are Early Offshoot of Modern Breed Dogs, Study Shows A (badly) stuffed lava bear: Show transcript: Welcome to Strange Animals Podcast. I'm your host, Kate Shaw. This week we have our annual updates episode, and we'll also learn about a mystery animal called the lava bear! As usual, a reminder that I don't try to update everything we've ever talked about. That would be impossible. I just pick new information that is especially interesting. After our episode about animals and ultraviolet light, I got a great email from Kelsey and Torin with some information I didn't know. I got permission to quote the email, which I think you'll find really interesting too: “You said humans can't see UV light, which is true, however humans can detect UV light via neuropsin (a non-visual photoreceptor in the retina). These detectors allow the body to be signaled that it's time to do things like make sex-steroid hormones, neurotransmitters, etc. (Spending too much time indoors results in non-optimal hormone levels, lowered neurotransmitter production, etc.) “Humans also have melanopsin detectors in the retina and skin. Melanopsin detectors respond to blue light. Artificial light (LEDs, flourescents, etc) after dark entering the eye or shining on the skin is sensed by these proteins as mid-day daylight. This results in an immediate drop in melatonin production when it should be increasing getting closer to bedtime.” And that's why you shouldn't look at your phone at night, which I am super bad about doing. Our first update is related to ultraviolet light. A study published in October of 2023 examined hundreds of mammals to see if any part of their bodies glowed in ultraviolet light, called fluorescence. More than 125 of them did! It was more common in nocturnal animals that lived on land or in trees, and light-colored fur and skin was more likely to fluoresce than darker fur or skin. The white stripes of a mountain zebra, for example, fluoresce while the black stripes don't. The study was only carried out on animals that were already dead, many of them taxidermied. To rule out that the fluorescence had something to do with chemicals used in taxidermy, they also tested specimens that had been flash-frozen after dying, and the results were the same. The study concluded that ultraviolet fluorescence is actually really common in mammals, we just didn't know because we can't see it. The glow is typically faint and may appear pink, green, or blue. Some other animals that fluoresce include bats, cats, flying squirrels, wombats, koalas, Tasmanian devils, polar bears, armadillos, red foxes, and even the dwarf spinner dolphin. In episode 20 we talked about Delcourt's giant gecko, which is only known from a single museum specimen donated in the 19th century. In 1979 a herpetologist named Alain Delcourt, working in the Marseilles Natural History Museum in France, noticed a big taxidermied lizard in storage and wondered what it was. It wasn't labeled and he didn't recognize it, surprising since it was the biggest gecko he'd ever seen—two feet long, or about 60 cm. He sent photos to several reptile experts and they didn't know what it was either. Finally the specimen was examined and in 1986 it was described as a new species.

Autism just magically shows up. In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics.(Start here) Regenerative Health with Dr. Max Guhlane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uATetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMITetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXsTryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079revAutism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567Regions of Interest:Atoms,Aromatic Amino Acids,Artificial Light,Chromophores,Cytochromes,Electromagnetic,Embryo,Folate Acid (and Folic Acid)Sunlight,Melanin (Neuromelanin),Melanocytes,Melanogenesis,Melanopsin,Mitochondria,Neuroectoderm,Neuroplasticity,Periodic Elements,Photoelectric Effect,Pro-opiomelanocortin (POMC)Proteins (wide-band gap semiconductors),Serotonin,Tryptophan Hydroxylase 1 and 2,Vitamins A, b9 (Folate/Folic Acids), B12, and D,WaterX: https://twitter.com/rps47586Facebook: https://www.facebook.com/fromthespectrum.podcastEmail: info.fromthespectrum@gmail.com

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.See Dr. Jack Kruse Quantum Engineering 45Email: info.fromthespectrum@gmail.com

In this podcast we discuss the non-visual photoreceptor system, mealonpsin, why sunlight helps your lose weight, pro-opiomelanocortin (POMC), why building melanin is an important health strategy, and much more.Zaid K. Dahhaj  is a men's health coach & co-host of The 2AM Podcast with extensive self education into the underlying drivers of chronic diseases. He has extensive knowledge of circadian biology and his current focus is on simplifying concepts surrounding our light environment and sunlight. Join my private MEMBERS Q&A Group (USD20/month)✅ https://www.skool.com/dr-maxs-circadian-resetLEARN how to optimise your Circadian Rhythm ✅ Dr Max's Optimal Circadian Health course

Oft wissen Menschen nicht, warum ihr Schlafverhalten gestört ist. Dafür gibt es viele Ursachen. Die wichtigste ist jedoch, welches Licht Du zu bestimmten Tageszeiten nutzt. Licht ist für unseren Biorhythmus verantwortlich. Es ist entscheidend, ob Du am Abend ausreichend Melatonin, das Schlafhormon, produzieren oder nicht. Welche Rolle das richtige Licht dabei spielt, erfährst Du in dieser Sendung.

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Why indoor lighting is hard to get right and how to fix it, published by Richard Korzekwa on the LessWrong. The days are getting shorter in the northern hemisphere, and with the ongoing pandemic, most of us expect to be spending more time in our homes than normal. Creating a healthy home environment is more important than usual, and the light inside your home is an often underappreciated part of this. There has already been some explicit discussion[1] about the importance of lighting for health and productivity, as well as many mentions of it in other places. Nonetheless, based on discussions I've had recently within the community, I get the impression that it is helpful for me to write up the results and tinkering that have done over the past few years. First, I will cover some of the research on how our bodies respond to light, and which particular characteristics of natural light we want to mimic. Then I will explain solving this problem is hard and my overall strategy for solving it. Finally, I will give some specific advice on what to buy and how to arrange things. I give quite a lot of background before offering any specific advice. Although I think the background information might help you make good decisions, you should feel free to skip the next section if you're in a hurry or if it seems uninteresting. Background Note: My background is in optics, not physiology or psychology and I began researching and writing this document almost four years ago. My original draft, as well as many of my sources, have been lost in the intervening years, so what you're seeing here is based on a combination of my notes that survived, my recollection of the research, and a partial duplication of the research. To make matters worse, it does seem that new research has come along since I began this project, so this is likely out of date. My guess is that most or all of the practical conclusions still stand, but I am only moderately confident of this. As much as I would like to take the time to update the research, past experience suggests that I will never actually publish it if I try to put too much more work into it. I welcome corrections, and if there is sufficient enthusiasm around this topic, I may try to write an updated version. Your body uses light to synchronize its internal clock and to modulate your mood and alertness[2]. While the particulars of the lighting in your environment are important, your only perceptual access to information about lighting in the moment comes from your visual system, which is poorly adapted to solving the problem of determining the intensity and spectrum of a light source. This is mainly because our vision is optimized more for accurately identifying materials, textures, colors, and other properties of our surroundings than it is for knowing details about sources of light. This has the consequence that some of our default intuitions about the nature of ambient light are wrong, so when we're building our lighting environment, it can be difficult to make accurate judgments just by looking at things. We can do better if we use quantitative measures and our scientific understanding of how things work to solve the problem. Physiology In addition to visual photoreceptors that are used for seeing things, your eyes contain non-visual photoreceptors which serve non-visual functions. Melanopsin is a photopigment that is found in cells in the retina[3]. It is sensitive to blue light, and when activated, these cells send signals that help with things such as regulating our internal clocks[4]. Unlike the our visual photoreceptors, which are more densely packed in the center of our retina[5] than in the periphery, these photosensitive cells are distributed relatively evenly throughout the retina[6], so that light coming from both the periphery and the cent...

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.282830v1?rss=1 Authors: Evangelisti, S., La Morgia, C., Testa, C., Manners, D. N., Brizi, L., Bianchini, C., Carbonelli, M., Barboni, P., Sadun, A. A., Tonon, C., Carelli, V., Vandewalle, G., Lodi, R. Abstract: Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive photoreceptors contributing to visual and non-image-forming functions of the eye. Isolating mRGC roles in humans is challenging, therefore mRGCs functions remains to be fully characterized. We explored mRGCs contribution to light-driven visual and cognitive brain responses in Leber's Hereditary Optic Neuropathy (LHON), given mRGC relative sparing in LHON. Twelve patients and twelve matched healthy controls (HC) participated in an fMRI protocol including visual and visual cognitive paradigms under blue (480nm) and red light (620nm). Higher occipital activation was found in response to sustained blue vs. red stimulation in LHON vs. HC. Similarly, brain responses to the executive task were larger under blue vs. red light in LHON over lateral prefrontal cortex. These findings are in line with LHON mRGCs relative sparing and support mRGCs contribution to non-visual and visual functions in humans, with potential implication for visual rehabilitation in optic neuropathy patients. Copy rights belong to original authors. Visit the link for more info

Dr. Satchin Panda (IG: @satchin.panda) is a professor at the Salk Institute and author of The Circadian Code. He is a frequent speaker in international conferences on metabolism, exercise and chronic diseases. Dr. Panda's research focuses on how circadian clocks regulate behaviour, physiology, and metabolism. His discovery of how a blue light sensor in our eyes affect our sleep-wake cycle, depression, and alertness is leading a new revolution in managing light to improve health. Dr. Panda recently discovered that maintaining a daily feeding-fasting cycle – popularly known as time-restricted eating (TRE) – can prevent and reverse many chronic diseases and increase lifespan. In this episode, we discuss: How you wake up is the most important part of your day Getting natural daylight in the morning The light-dark cycle trains our brain clock Melanopsin is sensitive to blue light (aka junk light at night) It takes 2-3 hours to build up your melatonin Simple solutions to manage light throughout your home Make sure to get 1-2 hours of bright light every day Mental health is linked to your sleep-wake cycle Optimal sleep amounts for all ages (babies to adults) Time-restricted eating (TRE) = eating during an 8-12 hour window Every cell in our body has its own clock Fasting makes your organs function better Why you should stop eating 2-3 hours before you sleep Finding the right TRE schedule for you Stop snacking to help burn fat Does coffee impact time-restricted eating? Dr. Panda’s personal experience with TRE How to best manage shift work & your eating schedule The Circadian Code in men vs. women The perfect circadian day Show sponsors: BLUblox

On Episode 5 of We All Know Nothing, we talk about the complexity of food, light, circadian rhythm and how they are all tied together. We introduce leptin and leptin resistance, and it's circadian aspect. Leptin is the hormone that controls fat metabolism and it’s tied to melanopsin the blue light photoreceptor. Melanopsin dysfunction is caused by artificial blue light, EMF and circadian disruption. Circadian disruption leads to leptin resistance, which is causing a lot of the health issues we see today. Eating a seasonal & local diet is only one factor in reestablishing your biological clock and fixing your health.

We examine a paper that finds sleep disruption from using tablet computers (as compared to reading a book in dim light). How much should we be worried about the effects of screens on a good night's sleep? There's good reason to believe that blue light is the main culprit -- recently discovered receptors in the eye that respond to blue light directly connect to brain areas implicated in sleep regulation. We lay out the case.... Papers: "Evening use of light-emitting eReaders.... (https://www.pnas.org/content/112/4/1232)" "Melanopsin: photoreceptors, physiology and potential (https://www.sciencedirect.com/science/article/pii/S2468867318301081)"

Kriben Govender (Honours Degree in Food Science & Technology) and Jame Shadrach (Honours Degree in Psychology) have a mind expanding discussion with neurosurgeon Dr Jack Kruse on how light may sculpt the microbiome and the implications for optimising your overall health today.   Bio:   Dr. Jack Kruse is a respected neurosurgeon and CEO of Optimized Life, a health and wellness company dedicated to helping patients avoid the healthcare burdens we typically encounter as we age. He is currently in private practice in the Gulf South.   As a neurosurgeon, Dr. Kruse’s research has been published in respected dental and medical journals. His popular blog, www.JackKruse.com, gets over 250,000 unique worldwide visitors per month from countries like Australia, Germany, Russia, and Zambia (Africa).   Topics discussed:   Jack’s health crisis The book that inspired Jack’s journey https://www.amazon.com/Monk-Who-Sold-His-Ferrari/dp/0062515675   Obesity linked to blue light, sunlight and non native electromagnetic fields Unlearning to relearn POMC https://en.wikipedia.org/wiki/Proopiomelanocortin POMC and morning sunlight (sunrise to 10am) The Sphinx Depression and Dopamine Serotonin, Melatonin and the Gut Brain Axis Tryptophan, melatonin and Cytochrome C Melatonin and mitochondrial autophagy and apoptosis Artificial Light at Night (ALAN) impact on Gut and Brain Light sculpts the microbiome  Surfaces exposed to light: eye, skin and gut Leptin stimulus What is Melanopsin?  Bacteria and light Fritz Popp and Biophotons- extreme low frequency ultra violet light https://en.wikipedia.org/wiki/Fritz-Albert_Popp Microbiome as a light intermediary Jeff Leech, Hazda Study https://youtu.be/tjLW_DaQ9qI The impact of human migration on the microbiome Bacteria and UV light NADH, Niacin and tryptophan The carbohydrate photon and Electron link via the Einstein’s photo electric effect Eye, skin and gut yolking Gut metabolite Methane: the hydrogen store Hydrogen Sulphide: gasotransmitter https://en.wikipedia.org/wiki/Gaseous_signaling_molecules#Sulfur_dioxide Nitric Oxide and electron chain transport Red light and ATPase Calorie restriction and sunlight Sulfation:  Mission microbiome Sulfation of blood and cholesterol Red light and the gut microbiome Methionine Cycle and heavy metals Riboflavin (B2) and Sulfation Blue light and the microbiome Sculpting the microbiome with sunlight The Epi Paleo Rx https://www.amazon.com/Epi-paleo-Rx-Prescription-Disease-Reversal-ebook/dp/B00BIUAZUQ Diet and light Photobiomodulation Tina Kuru Jeff Leech’s new study Jack’s No 1 Gut health recommendation: https://www.amazon.com/Light-shaping-life-Biophotons-medicine/dp/9081884328     Brought to you by:   Nourishme Organics- Gut Health Super Store- Shine from the Inside   Shop Gut Health and Fermentation- 10% off using code:  jack   https://www.nourishmeorganics.com.au/collections/beginner-recommendations-start-here     Allele Microbiome- Gut Microbiome and Deuterium Testing   Microbiome Stool testing (10% off Gut Explorer Pro Kit using code: gutlove)    https://www.allele.com.au/collections/frontpage/products/gut-microbiome-analysis   Deuterium Testing (10% off Deuterium Explorer Kit using code: deuterium)   https://www.allele.com.au/collections/frontpage/products/deuterium-explorer     Connect with Dr Jack Kruse   Website- https://jackkruse.com/    Connect with Kriben Govender:    Facebook- https://www.facebook.com/kribengee/ Instagram- https://www.instagram.com/kribengovender/ Youtube- https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1 Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/ Mito Wellness Support Facebook Group: https://www.facebook.com/groups/347845406055631/   Download links                 If you enjoyed this episode and would like to show your support:   1) Please subscribe on Itunes and leave a positive review     Instructions:   - Click this link  https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2   - Click "View in Itunes" button on the left hand side - This will open Itunes app - Click "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button   Non Itunes user’s can leave a Google Review here: http://bit.ly/nourishmeorganics   2) Subscribe, like and leave a positive comment on Youtube   https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1   3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc   5) Support us on Patreon for as little as $5 per month and get same day, early access to our latest podcasts (typically around 4 to 6 weeks earlier than the general public) https://www.patreon.com/nourishmeorganics   Thank you so much for your support. It means the world to us.    

Andy Mant is the Founder and CEO of BluBlox, a company who produces high-quality blue light blocking glasses. Andy and Boomer discuss the role of melanopsin, how to regulate blue light, and the role of circadian rhythms for performance.   "When the sun rises in the morning and as it actually sets in the evening, the intensity of light changes. During first sort of sunrise periods, you're going to have a very low lux light. It is probably about sort of 1800 Kelvin on the sunrise and the sunset. It's actually not really that difficult to look at and it also contains a lot yet less frequencies of invisible light like UV." Andy Mant, CEO of BluBlox   Who is Andy Mant?   Andy Mant is the founder and CEO of BLUblox, a company specializing in evidence-based advanced light filtering eyewear. Andy started BLUblox after becoming dissatisfied with the quality and standards of blue light blocking glasses available and so set about to design lenses that match the evidence in the academic literature. Andy was born in the UK and moved to Australia in 2011. After moving and about 2 years after arriving Andy’s gained a lot of weight and become chronically fatigued and lacked energy. Traditional dietary approaches only worked to a certain degree and after stumbling across light and health Andy forged a passion and niche understanding of all things light related to health. Today Andy is a leading figure in managing light to improve health and wellbeing.   Key Highlights on Optimizing Light   [5:27] Andy Mant's health journey [9:44] How to reset your circadian rhythm [12:04] The relationship between cortisol and blue light [14:19] Practicing sun gazing [16:09] The best resources for diving deep on circadian rhythms [22:27] Melanopsin in detail [25:31] Why blue light blocking glasses at night is not enough [30:21] Taking a light break from work [34:14] An after dark routine to optimize your sleep [37:21] Reducing flicker with Iris [39:01] Does it matter if the light gets in the side of the glasses? [41:25] The role of melanin in needing sunglasses [49:55] Testing different blue light blocking brands [53:22] The question you should ask of the manufacturer of your glasses [55:20] Andy answers the final four questions   Resources Mentioned   Jack Kruse - Epi-Paleo Rx Jack Kruse website The emerging roles of melanopsin in behavioral adaptation to light Iris - software for blocking blue light Spectrum test results of different blue light blocking glasses The Story of the Human Body: Evolution, Health, and Disease by Daniel Lieberman Amber lenses to block blue light and improve sleep: a randomized trial. MitoLife The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight   Continue Your High Performance Journey with Andy Mant   Light and Health Facebook Group Andy Mant on Instagram Andy Mant on Twitter BluBlox company website   Sponsor   The sponsor for this episode is the ring on my finger. No, I’m not married yet. And frankly, before that ring, I hated wearing rings. But I must say the guys at Oura have done a great job.   The ring allows me to track all sorts of crazy things about my sleep, including my resting heart rate, my deep sleep stages, my REM sleep, etc, etc. I really enjoy the feedback and allows me to make lifestyle decisions to become a higher performer.   Let me give you an example. So prior to getting the ordering, I would fast essentially 16 hours after my last meal. It didn’t matter when that last meal was. However, when I look at my resting heart rate, and how that really correlates to my performance The next day, I know I want my lowest resting heart rate coming as soon as possible after going to sleep because that’s when all my recovery really starts.   So what did I do? Well, it allowed me to adjust really when my last meal was before going to bed. So I have my last meal. Now, earlier in the night, I get better sleep, I get higher quality sleep. And I must say the next day feels amazing. So if you want to check out the Oura Ring and if you want to pick one up yourself, go to ouraring.com and plug in the code Boomer and you’ll get $50 off your order or 50 euros, depending on your jurisdiction. I really hope you enjoy the ring and on with the show.   Disclaimer   This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

Host Kevin Patton previews the content of the upcoming full episode, which focuses on powering up how we do dissection activities.   There's more... a few content updates... plus feedback from listener Mindi Fried,  some word dissections and a recommendation from The A&P Professor Book Club. If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336)Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!   Topics 1 minute Summer Neuroscience Workshop Ganglion cells in the retina Powering up our dissection activities Dissection lists Pre-dissection activity Feedback 4 minutes Mindi Fried weighs in on the value of preview episodes.  As we approach the anniversary of this podcast, let's hear what you think! podcast@theAPprofessor 1.833.LION.DEN (1.833.546.6336) Word Dissections 6 minutes Suprachiasmatic nucleus (SCN) Melanopsin Rhodopsin Photopsin Circadian Book Club 3 minutes The Physician (The Cole Trilogy Book 1) by Noah Gordon Book details: amzn.to/2LzEvDO Historical fiction Story of a European who studies medicine under Persian physician Avicenna (Ibn Sina) my-ap.us/2ShqeOD If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Join The A&P Professor social network: Blog Twitter @theAPprofessor Facebook theAPprofessor Instagram theAPprofessor YouTube Amazon referrals help defray podcasting expenses.Transcript and captions for this episode are supported by theAmerican Association of Anatomists.anatomy.org The Human Anatomy & Physiology Societyalso provides support for this podcast.theAPprofessor.org/haps(Clicking on sponsor links helps let them know you appreciate their support of this podcast!)

Throughout evolution, exposure to sunlight and the photosynthesis of vitamin D has been critically important for the evolution of land vertebrates. But all of a sudden in the past few decades, we have been burying the Sun from our lives while simultaneously increasing our exposure to artificial light. Could this be a foundational mistake for our health? Has the status quo's fear of the sun been blown out of proportion?Circadian medicine won the most recent Nobel Peace Prize saying that a resolution towards chronic disease is to live in-tune with our natural circadian rhythms. Simply, 'go back to nature' is now the prescription healing. Dylan and Laura will share how to work with the Sun to optimise your health and immune system, so you can re-establish this important and foundational human-Sun relationship.This recording is from a talk where Laura interviewed Dylan in Melbourne in September 2018.ABOUT LAURA POOLELaura Poole is a Vedic meditation teacher, speaker, writer and community builder. She has trained intensively over the past decade with great masters in Australia, India and the United States. Based in Melbourne, Laura shares the wisdom of Vedic meditation, Vedanta and Ayurveda, making it relevant for living in today's world. She is a truly dedicated leader and entrepreneur in the Melbourne meditation space, inspiring people to take care of their mental and physical health while encouraging them to make a real difference in the world.Laura is the founder of Mahasoma - a movement that is creating a new cultural narrative through the embodiment of wisdom and practice. She was also an original co-founder/co-creator of 1 Giant Mind Australia and its free 'Learn to Meditate' app.IN THIS EPISODE WE DISCUSSHow Dylan became fascinated and in love with the sun.Forming a relationship with the sun.Circadian MedicineThe Personality of the Sun.The Lighting Crisis: Burying the sun from our lives and replacing this with artificial blue light.Receiving an Altered Spectrum of LightThe problem with sunscreen, windows and glasses.The eyes as a seat of pitta (fire/metaboliser).The importance of melatonin: “The king of hormones.”Our Mistaken Fear of the SunWhy the Sun Rarely Causes Skin CancerThe difference between morning and evening light spectrums.Under Active Thyroid The Vital Time for SleepThe Influence of LED Lights (Screens, Lights) and Light Temperatures on our HormonesHacking our Computer and Phone Screens to Reduce Light Temperature for Hormonal HealthThe Epidemic of Eye Diseases.Detoxifying Fluoride and Excess Calcium from the Pineal GlandBuilding Biology Skin Physiology and why blind people still have light and dark cycles.Melanopsin and photoreceptors in our skin.Self-Abhyanga (Self-Ayurvedic Massage)The Second Brain: The GutThe Third Brain: The SkinThe sense of Touch (SparshaSupport the show (https://www.paypal.com/donate/?token=y_kaqK9wLLV2hJsCYl7mFwBcEPNGyuzRIZuHMW5dxoRj2vyQJPvcov1xOO9ZUsn_lG-6Km&country.x=AU&locale.x=AU)

What are colours? What is colour? Just different wavelengths of light...mental (Wikipedia) Visible light (NASA) The visible spectrum (Wikipedia) What is electromagnetic radiation? (livescience) Spectral colours (HyperPhysics, Georgia State University) What wavelength goes with a colour? (NASA) Rabbit & Spaghetti Shiraz (Naked Wines) This is your brain on nature (National Geographic) Your colour red could really be my blue (livescience) How my friends described colours to me when I couldn't see (li.st) How colours get their names (livescience) Colour vision in humans & other species (Wikipedia) A nice overview on rods & cones (HyperPhysics, Georgia State University) How do we see colour? (livescience) Photoreceptor cells (Wikipedia) Bayer filter mosaics: How red, green & blue is arranged on our screens to complement our colour vision (Wikipedia) Theory of colours (Wikipedia) Newton & the colour spectrum (Web Exhibits) Newton's theory of light: His experiment split white light through a prism to make a rainbow, then recombined it through another prism to make white light again (The Star Garden) Michelangelo Merisi da Caravaggio (Caravaggio Foundation) Dark Side of the Moon, Pink Floyd (Ultimate Classic Rock) Red light is just a photon of a certain energy: The wavelength of red light is 650 nm, blue is 475 nm & green is 510 nm (Montgomery Blair High School) Can you hear colour? Some people with 'synesthesia' claim to be able to (livescience) What is synesthesia? (Scientific American) Human ears respond to frequencies of sound between about 20 Hz to 20,000 Hz (Wikipedia) Human eyes respond to wavelengths of light between about 390 nm to 700 nm (Wikipedia) What is infrared light? It's just below (longer than) the wavelength of visible red light, so humans can't see it (Wikipedia) Infrared waves (NASA) Night vision goggles 'extend' your vision into the infrared (Wikipedia) Humans give off infrared radiation (Science Questions With Surprising Answers) The longest waves are 'radio waves', further along than infrared - they're still photons of energy, we just can't see them (livescience) Radio waves (NASA) Shorter waves than blue are 'ultraviolet' (UV), they're at a shorter wavelength/higher energy than we can see (NASA) What is ultraviolet light? (livescience) Do rainbows have ultraviolet bands & infrared bands? (Physics StackExchange) Shorter waves than UV are X-rays, they're at a shorter wavelength/higher energy than we can see (NASA) The shortest waves are 'gamma waves', they're still photons of energy, we just can't see them (NASA) We need different types of telescopes to 'see' the different types of waves in the universe: radio, infrared, visible, X-ray, gamma (NASA) Mantis shrimps & bees can see UV light (Catalyst) The absorption spectrum of water: There's an interesting dip right at the wavelengths of visible light (Wikipedia) The absorption spectrum of water (London Southbank University) Transparency of water in the visible range (HyperPhysics, Georgia State University) Some creatures are 'pentachromats', i.e. they have 5 different types of colour receptors in their eyes (Wikipedia) What is melanopsin? (Wikipedia) Melanopsin probably evolved ~1 billion years prior to cone cells: These receptors independently gauge the amount of blue or yellow incoming light & route this information to parts of the brain involved in emotions & the regulation of the circadian rhythm (livescience) Someone who is colour blind is missing 1 or more of the 3 sets of colour-sensing cones (Wikipedia) How we see colours: Light absorption, reflection & transmission (the Physics Classroom) Sunderland claims the first stained glass in England (BBC, Radio 4) Sunderland National Glass Centre Visible light & the eye's response (the Physics Classroom) You can't mix all the colours & get white paint (Reference) Why does mixing every paint colour produce grey not white? (Physics StackExchange) White light is all of the frequencies of light (Reference) The colours of light (Science Learning) Colour: Travels through the paintbox - the book Johnny mentioned (Victoria Finlay) Photodegradation, "the alteration of materials by photons of light", is why colours fade (Wikipedia) Photodegradation & photostabilisation of polymers: A proper sciencey paper (SpringerPlus) Some answers to the question 'Why does colour fade when left in sunlight?' (Reddit) What is ink? (Wikipedia) What are dyes? (Encyclopaedia Britannica) Why are plants green? Because they absorb red light & reflect green light from the sun! (UCSB ScienceLine) More detailed answers to why plants are green (ResearchGate) Blue sky & Rayleigh scattering (HyperPhysics, Georgia State University) Goat moisturing lotion (The Goat Skincare) A history of inks, dyes & pigments (World of Chemicals) People have been dyeing fabric indigo blue for 6,000 years (The New York Times) Effect of light exposure on paintings (National Gallery of Art) What is oil painting? (Encyclopaedia Britannica) Pigments used by different artists, including Caravaggio (Pigments through the Ages) Printed photos fade, but so too can photos saved to disk! (Bloomberg) Cultures see & name colours differently (BBC, Future) Newton & the indigo controversy (Wikipedia) Italian, Russian & Hebrew has 12 basic colour terms (English has 11) & they distinguish blue & azure (Wikipedia) Colour naming: Azure is distinct from blue in Russian & Italian, but not English (Wikipedia) Eskimo words for snow...could be a myth (Wikipedia) How many words do the Inuits have for snow? (The Guardian) What's in a colour? The unique human health effects of blue light (Environmental Health Perspectives) This article suggests penguins can see violet, green & blue, but not red (National Wildlife Federation) This is what I was trying to explain to Johnny, quite poorly, "...even if you perceive the sky as the colour someone else would call 'red', your blue sky still makes you feel calm", because of the 'blue' frequency of the light (livescience) Where are you from? Send us a postcard! Strange Attractor, c/ PO Box 9, Fitzroy, VIC 3065, Australia Corrections The human retina contains ~120 million rod cells, not 15 million (Wikipedia) Cheeky review? (If we may be so bold) It'd be amazing if you gave us a short review...it'll make us easier to find in iTunes: Click here for instructions. You're the best! We owe you a free hug and/or a glass of wine from our cellar Click to subscribe in iTunes