Podcasts about salk institute

We are a movable species. In less than 50 thousand years, Homo sapiens has penetrated practically all corners of humanity. And the story started long before trains and airplanes. This is an episode about thoese epic migrations, with a focus on the two furthest edges of the human migratory map: the Americas in the West and the Polynesian islands in the east. In the end, we discuss emerging evidence that those branches met each other -- work coming directly out of the work of my guest, Andrés Moreno-Estrada.Enjoy!DECODING OUR STORYThis is episode 3 in the "⁠Decoding Our Story⁠" mini-series, recorded live at the Salk Institute's CARTA symposium on ancient DNA. The other episodes are:"The Neanderthal Mirror: Latest Findings About the Lines Between Us" ~ David Gokhman "Beyond Race: A New Outlook on the Shape of Humanity" ~ Diyendo MassilaniFACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: ⁠⁠⁠OnHumans.Substack.com⁠⁠⁠Support: ⁠⁠⁠Patreon.com/OnHumans⁠⁠⁠Contact Form: ⁠⁠⁠https://forms.gle/h5wcmefuwvD6asos8⁠⁠⁠⁠CARTA symposium⁠⁠The Moreno lab⁠⁠KEYWORDSHuman population history | Human origins | Anthropogeny | Anthropology | Ancient Migration | Out of Africa | Homo sapiens | Ancient DNA | Comparative genetics | Austronesian expansion | Taiwan | Admixture | Archaeogenetics | Archaeology | Polynesia | Easter Islands | Rapa Nui | Hawai'i | Aotearoa New Zealand | Tonga Fiji | Native American origins | Latino genetics | Latinx genetics | Hispanic genetics | Indegenous genetics |

European thinkers once divided humanity into distinct "races". The idea stuck, even if the science moved on. The shape of humanity, it turned out, is far messier than the old race theorists ever imagined.This much is well known.Still , genetics does study different human "populations". Biological differences between these populations are reported every day. So have we simply changed words? Has anything really changed?Yes, everything has changed. To explain why, I'm glad to have Diyendo Massilani on the show.Trained in France and Gabon, Massilani runs a lab at the Yale School of Medicine, where he studies ancient DNA and human adaptations. This fall, his lab has produced one of the most interesting analysis of human biodiversity that I have ever seen. I'm proud to feature it on the podcast before publication. Our conversation begins from the counter-intuitive implications of the Out of Africa theory, and its significance for ideas about race. We then discuss Massilani's own analysis about how the level of genetic differences between modern-day humans.As always, we finish with my guest's reflections on humanity. DECODING OUR STORYThis is episode 2 in the "Decoding Our Story" mini-series, recorded live at the Salk Institute's CARTA symposium on ancient DNA. The other episodes are:"The Neanderthal Mirror: Latest Findings About the Lines Between Us" ~ David Gokhman (published)"Restless Humanity: The Epic Migrations Into America, Polynesia, and... Beyond?" ~ Andrés Moreno-Estrada (4th of Dec)FACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: ⁠⁠OnHumans.Substack.com⁠⁠Support: ⁠⁠Patreon.com/OnHumans⁠⁠Contact Form: ⁠⁠https://forms.gle/h5wcmefuwvD6asos8⁠⁠CARTA symposium⁠The Massilani lab⁠KEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Paleoanthropology | Genetics | Homo sapiens | Ancient DNA | Comparative genetics | Human biodiversity | Admixture | Archaeogenetics | Archaeology | Mbuti | Papuans | Neanderthals

No Time To Read podcastS4E1Drought Recovery-Induced Immunity (DRII)    Guest: Natanella Illouz-Eliaz, Ecker lab, Salk Institute for Biological StudiesX: @NatanellaEBlueSky: @natanellae.bsky.social  Host: Arif Ashraf, Assistant Professor, University of British Columbia X/BlueSky: @aribidopsis

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]

Genetics is rewriting the human story. This week, On Humans takes you behind the scenes of this rapidly evolving frontier via three live-recordings, captured at the Salk Institute's CARTA symposium on ancient DNA. The first episode explores the differences between us and the Neanderthals.For centuries, we tried to understand Neanderthals through stones and bones alone. Now genetics is offering a new tool, allowing researchers to see how ancient bodies and brains developed. In this opening episode, David Gokhman explains what these new tools are revealing about us, Neanderthals, and the lines between us.UP NEXT "Beyond Race: New Surprises About the Shape of Humanity" ~ Monday Dec 1st with Diyendo Massilani"Restless Humanity: The Epic Migrations Into America, Polynesia, and... Beyond?" ~ Thursday Dec 4th with Andrés Moreno-EstradaFACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: ⁠OnHumans.Substack.com⁠Support: ⁠Patreon.com/OnHumans⁠Contact Form: ⁠https://forms.gle/h5wcmefuwvD6asos8CARTA symposiumGokhman's labKEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Archaeogenetics | Archaeology | Paleoanthropology | Genus Homo | Neanderthals | Ancient DNA | Comparative genetics | Archaeogenetics | Language evolution | Origins of language | Symbolic culture | Extinction | Species concept

Neuroscience has long focused on neurons, but researchers are turning their attention to another kind of brain cell: glial cells. These non-neuronal cells help shape information processing, support brain circuits and influence vulnerability to neurodegenerative diseases — and there are roughly as many glial cells in the human brain as neurons.Terrence Sejnowski, PhD, is a professor and laboratory head of the Computational Neurobiology Laboratory and Francis Crick Chair at the Salk Institute for Biological Studies. In a recent Salk study, he and his team compared glial cell organization across different brain regions and mammal species, finding striking patterns in how these cells are arranged. His work looks at how glial cells differ across brain regions and species, and what those patterns might mean for brain function and disease risk.In this interview, Sejnowski explains the three main types of glial cells and their roles: astrocytes that help feed neurons and support learning and memory, microglia that act like janitors clearing waste and damage, and oligodendrocytes that insulate nerve fibers so signals travel faster. He discusses how glial cells help clean the brain during sleep, how they may be involved early in conditions like Alzheimer's and multiple sclerosis, and why some research suggests glia could be a better marker of brain health than neurons alone. His insights point to a future in which understanding and protecting glial cells could open new paths for prevention and treatment.—-If you loved watching this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter: https://twitter.com/Being_Patient_Instagram: https://www.instagram.com/beingpatientvoices/Facebook: https://www.facebook.com/beingpatientalzheimersLinkedIn: https://www.linkedin.com/company/being-patientBeing Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://www.beingpatient.com/category/video/

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

On October 30, 2025, at 9:00 a.m. PT/12:00 p.m. ET, the Salk Institute holds a special live, video edition of our Beyond Lab Walls podcast as we explore why science can't wait. Salk's Vice President of Advancement Michelle Chamberlain will host an in-depth conversation with Chief Science Officer Jan Karlseder and Chief Financial Officer Marie Carter-Dubois about the urgent importance of foundational research—and how it depends on the vital partnership between federal funding and private philanthropy. Discover how current funding challenges are impacting scientific progress and why continued support is essential for breakthroughs that can change the world.

Dr. Diane Hennacy is a Johns Hopkins-trained neuropsychiatrist, author, public speaker, and independent researcher exploring the intersection of science, consciousness, and anomalous phenomena like telepathy and psychic abilities. With over 30 years of clinical experience, she has served on the faculty at Harvard Medical School and participated in think tanks on human consciousness at the Salk Institute. Hennacy's groundbreaking work bridges rigorous scientific inquiry with mysteries of the mind, including studies on autism, savant syndrome, and potential links to extrasensory perception (ESP). Her bestselling book, The ESP Enigma: The Scientific Case for Psychic Phenomena (2009), presents evidence from neuroscience, quantum physics, and case studies to explain psychic experiences. A student of ancient wisdom traditions and an award-winning clinician, she has spoken at international scientific conferences, the United Nations, and venues like TEDx, advocating for open-minded exploration of human potential and consciousness. Hennacy, who also held the title of Miss Oregon Senior America 2017, continues her research through the Hennacy Institute for Consciousness Research, emphasizing integrative medicine and the evolution of human awareness. Shawn Ryan Show Sponsors: https://americanfinancing.net/srs NMLS 182334, nmlsconsumeraccess.org. APR for rates in the 5s start at 6.327% for well qualified borrowers. Call 866-781-8900, for details about credit costs and terms. https://tryarmra.com/srs https://aura.com/srs https://betterhelp.com/srs This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. https://bubsnaturals.com – USE CODE SHAWN https://shawnlikesgold.com https://mypatriotsupply.com/srs https://patriotmobile.com/srs https://ROKA.com – USE CODE SRS https://shopify.com/srs https://trueclassic.com/srs https://USCCA.com/srs Dr. Diane Hennacy Links: Website - https://drdianehennacy.com X - https://x.com/drhennacy41125 Buy The ESP Enigma - https://drdianehennacy.com/purchase-esp-enigma Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Todd Michael is a leading researcher specializing in genome sequencing and analysis, currently serving as a Research Professor at the Salk Institute for Biological Studies and an Adjunct Professor at the University of California, San Diego.  His research has made significant contributions to understanding plant genome architecture, particularly through the study of unique and specialized plants that offer insights into adaptive strategies. His innovative work on pangenome tools and long-read sequencing technologies has advanced the understanding of how plant genomes are organized and how they adapt to specific environmental conditions. At CannMed 25, Todd presented “Cannabis Pangenome Exposes Minor Cannabinoid Pathway Potential”, which described how his team integrated 193 cannabis genomes to identify extensive genetic and structural diversity and highlight potential breeding bottlenecks. During our conversation, we discussed: What is a pangenome and why has it replaced single reference genomes Why cannabis is the most interesting plant genome Todd has worked with What has caused cannabis to be one of the world's most diverse plants How transposable elements AKA “jumping genes” contribute to cannabinoid synthase The potential risks of excluding males plants from breeding and more Thanks to This Episode's Sponsor: Advanced Nutrients Founded in 1999, Advanced Nutrients was the first to develop a complete nutrient system that unlocks the true genetic potential of the cannabis plant. Since its inception, the brand has introduced more than 50 innovations to the cultivation community and continues to revolutionize the space through proprietary scientific discoveries.  Learn more at AdvancedNutrients.com Additional Resources Michael Lab Website CannMed Video Archive CannMed 25 Photo Gallery

Andrew Humberman BioSnap a weekly updated Biography.Andrew Huberman has been especially active and visible over the past week with developments spanning science advocacy, public speaking, and media attention. He recently appeared on HBO's “Overtime with Bill Maher” alongside Frank Bruni and Christopher Rufo, engaging in a lively debate on issues ranging from free speech to modern culture—a segment that generated strong buzz among both neuroscience followers and general viewers, with PBS News Weekend and CBS Evening News recapping highlights. On the business front, Huberman continues to expand his podcast's reach, with “Huberman Lab” dropping two major episodes. The first, “Science and Health Benefits of Belief in God and Religion,” featured Dr. David DeSteno and explored topics that go well beyond neuroscience: the impact of religious rituals on mental health, nuanced distinctions between community-based support and faith-based resilience, and the intersection of AI and religious experience. This episode attracted tens of thousands of viewers and contributed to ongoing discussions about how belief systems affect longevity and psychological wellbeing, as confirmed by David DeSteno's longitudinal research at Northeastern University. A fresh “Huberman Lab Essentials” episode focused on fasting and time-restricted eating, distilling decades of metabolic research from Stanford's Christopher Gardner and Salk Institute's Satchin Panda. Here, Huberman shared protocol-level advice on 8-hour feeding windows, the circadian rhythm's role in fat loss, and how even simple strategies—like post-meal walking—can accelerate glucose clearance. Social media is abuzz with references to these episodes, amplified by Huberman's trademark dissemination of evidence-based actionable routines, including his Daily Blueprint which remains a top resource for his 800,000-plus newsletter subscribers, as confirmed on his site.Notably, a viral Men's Journal article revealed Huberman's top “dog trick” for instant stress relief, pointing readers to short, rapid breathing as a potent tool for anxiety—this simple protocol was highlighted by Huberman as rooted in comparative animal behavior and neuroscience and has already been widely circulated among health and wellness creators. Meanwhile, the anticipation grows for his public keynote at the Summit of Greatness in Los Angeles next month. Lewis Howes announced on Threads that Huberman is a headline speaker, with tickets already in high demand, and numerous videos on social media document the excitement and scramble for seats. There is no credible evidence of controversy, major business pivots, or speculative claims about his activities. The overarching headlines emphasize Huberman's unflagging pace in both science outreach and mainstream discourse, cementing his status as not just a leading neuroscientist but a cultural force in the public understanding of health and human performance.Get the best deals https://amzn.to/3ODvOta

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

If you've found yourself scrolling through the breastfeeding world online, you know that people have a lot of strong opinions about breast milk. But what exactly do we know about the biology of it? Does breast milk really adapt to a baby's needs? Does it confer immunity? How does making breast milk impact the breastfeeder? Joining Host Flora Lichtman to spin through the science of this sophisticated substance are experts Shelley McGuire and Deepshika Ramanan.Guests: Dr. Shelley McGuire is the director of the Margaret Ritchie School of Family and Consumer Sciences at the University of Idaho.Dr. Deepshika Ramanan is an assistant professor at the Salk Institute for Biological Studies.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

In this episode of the Epigenetics Podcast, we talked with Dr. Joseph Ecker from the Salk Institute about his work on high-resolution genome-wide mapping technologies, specifically how the regulation of gene expression is influenced by DNA methylation, chromatin accessibility, and non-coding RNAs across various cell types and developmental stages. During our conversation, we delve into Dr. Ecker's contributions to the characterization of the genome of Arabidopsis thaliana, a project pivotal in the plant genomics field, where he collaborated on the early sequencing efforts that dramatically outpaced expectations. He highlights the technological advancements that enabled such efficient sequencing and how this foundational work opened new avenues for exploring transcriptional activity. We also discuss Dr. Ecker's pivotal work on the comprehensive DNA methylation map of Arabidopsis, which he developed in collaboration with other researchers. This groundbreaking study established the links between methylation patterns and gene expression, paving the way for further research into how these epigenetic marks influence over gene regulation. He elaborates on the significance of transitioning from traditional methods to more sophisticated techniques, such as RNA-seq, and the lessons learned from sequencing projects that have since been applied to human biology. Dr. Ecker's transition to studying human cells is further explored as he discusses the profiling of DNA methylation in induced pluripotent stem cells (iPSCs), revealing how epigenetic memory can influence cellular differentiation and development. He underscores the importance of understanding these methylation patterns, particularly as they relate to conditions like Alzheimer's disease and stem cell biology, where he examines potential applications of his findings in medical research. As our conversation progresses, we touch upon Dr. Ecker's ongoing projects that utilize advanced multi-omic techniques to investigate the epigenomes of the human brain, focusing on how DNA methylation and gene expression change with age and in the context of neurodegenerative diseases. He details the collaboration efforts with various consortia aimed at cataloging gene regulatory networks and understanding the complex interactions that take place within the brain throughout different life stages.   References Mozo T, Dewar K, Dunn P, Ecker JR, Fischer S, Kloska S, Lehrach H, Marra M, Martienssen R, Meier-Ewert S, Altmann T. A complete BAC-based physical map of the Arabidopsis thaliana genome. Nat Genet. 1999 Jul;22(3):271-5. doi: 10.1038/10334. PMID: 10391215. Zhang X, Yazaki J, Sundaresan A, Cokus S, Chan SW, Chen H, Henderson IR, Shinn P, Pellegrini M, Jacobsen SE, Ecker JR. Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell. 2006 Sep 22;126(6):1189-201. doi: 10.1016/j.cell.2006.08.003. Epub 2006 Aug 31. PMID: 16949657. Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, Millar AH, Ecker JR. Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell. 2008 May 2;133(3):523-36. doi: 10.1016/j.cell.2008.03.029. PMID: 18423832; PMCID: PMC2723732. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009 Nov 19;462(7271):315-22. doi: 10.1038/nature08514. Epub 2009 Oct 14. PMID: 19829295; PMCID: PMC2857523. Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):68-73. doi: 10.1038/nature09798. Epub 2011 Feb 2. Erratum in: Nature. 2014 Oct 2;514(7520):126. PMID: 21289626; PMCID: PMC3100360.   Related Episodes Epigenetic Reprogramming During Mammalian Development (Wolf Reik) Single Cell Epigenomics in Neuronal Development (Tim Petros)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Chris Mirabile's journey into health and longevity began with a preteen's desire to impress girls during school fitness tests—but quickly evolved into something deeper. By age 12, Chris was reading Men's Health, refining his diet, and obsessing over performance, though he later realized much of his early approach to health was misguided. At 16, his life took a dramatic turn when he suffered a seizure during a school field trip and was diagnosed with a large brain tumor. Emergency brain surgery saved his life, but the experience left a lasting impression, igniting a relentless drive to understand human biology and wellness. ⁣ Though he studied finance and entrepreneurship at NYU, Chris immersed himself in scientific research, especially in bio-gerontology—the biology of aging. Long before it was a buzzword, he was poring over PubMed studies, using genetic testing tools, and analyzing his own DNA to uncover predispositions that might have contributed to his tumor. After early success and eventual failure with a social media startup, Chris doubled down on his passion for health optimization. He founded Novos, a company dedicated to slowing the aging process through science-backed supplements and nutrition, collaborating with researchers from institutions like Harvard, MIT, and the Salk Institute. ⁣ Today, Chris combines rigorous science with real-world application. He launched NovoScore, a daily supplement targeting all 12 known mechanisms of aging, and developed a science-forward meal replacement bar that emphasizes longevity-promoting ingredients over trendy marketing. Through Novos and his personal platform SlowMyAge, Chris educates others on optimizing biological age, drawing from cutting-edge research in omics sciences and data-driven health tracking. With over 10 million supplement doses taken and partnerships expanding, Chris's mission is clear: to empower people to live longer, healthier, and more vibrant lives through informed, evidence-based choices.

Dr. Satchin Panda is a renowned neuroscientist and professor at the Salk Institute for Biological Studies. He is best known for his groundbreaking research on circadian rhythms, time-restricted eating, and their impact on metabolism and overall health. His work has significantly influenced the fields of chronobiology and nutrition. Dr. Panda is also the author of The Circadian Code, where he shares practical strategies to optimize health by aligning daily routines with the body's internal clock.In our conversation we discuss:(00:00) – What happens in our bodies when our circadian rhythm is out of sync(06:16) – How to know if your circadian rhythm is out of sync(11:07) – What matters more: timing of sleep or how long is your sleep(15:47) – Consistency in your sleep schedule(18:37) – Importance of getting bright natural light(24:23) – Resetting circadian rhythm for a night shift worker(28:54) – Product recommendation(30:50) – Compensating for lost or poor sleep(34:31) – What are the worst common habits the generation is doing that harm the quality of sleep(40:45) – Eating late in relation to quality of sleep(42:59) – Supplements(48:15) – Prolonged fasting(51:05) – Time window for liquid intake(54:07) – Sipping(56:10) – Exercising in the morning vs in the afternoon(59:24) – Factors that may be overlooked in improving circadian rhythm(1:01:32) – Ideal circadian dayLearn more about Dr. Satchin Panda:https://www.salk.edu/scientist/satchidananda-panda/https://www.instagram.com/satchin.panda/?hl=enhttps://www.linkedin.com/in/satchin-panda-926ba369App: https://www.mycircadianclock.org/Book: https://www.amazon.com/Circadian-Code-Supercharge-Transform-Midnight/dp/163565243XWatch full episodes on: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@seankim⁠⁠⁠⁠⁠⁠⁠Connect on IG: ⁠⁠⁠⁠⁠⁠https://instagram.com/heyseankim

Send us a textShort Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer's.About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Pamela Maher discusses her research on cell death mechanisms, including apoptosis and ferroptosis, and their roles in health and disease. They discuss how oxidative stress from reactive oxygen species can damage cells, the body's antioxidant defenses like glutathione and studies on natural compounds—fisetin, curcumin, and cannabinol (CBN)—that may protect against brain cell loss. The conversation covers CBN's mitochondrial benefits in aging mouse models and broader risk factors for dementia, like obesity and hearing loss, emphasizing early intervention.Key Takeaways:Apoptosis is a controlled cell death process vital for development, while ferroptosis, linked to oxidative stress and iron, causes cells to burst and is tied to diseases like Alzheimer's.Oxidative stress arises when reactive oxygen species overwhelm antioxidants, damaging DNA, proteins, and cell membranes, especially polyunsaturated fats.Glutathione, a key antioxidant, relies on cysteine and declines with age, but supplements like N-acetylcysteine might help, though tolerability varies.Cannabinol (CBN), a THC byproduct, protects mitochondria and improves memory in aging mice, hinting at therapeutic potential beyond cannabinoid receptors.Middle-age risk factors like visceral obesity, type 2 diabetes, and hearing loss significantly increase dementia risk, but hearing aids can reduce it.Related episode:M&M #165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical aSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Diane Hennacy Powell, M.D. is the chief scientist involved in The Telepathy Tapes, a podcast about non-speaking autistic children who are extraordinarily telepathic. "In a world that often dismisses the extraordinary as mere fantasy, The Telepathy Tapes dares to explore the profound abilities of non-speakers with autism—individuals who have long been misunderstood and underestimated. These silent communicators possess gifts that defy conventional understanding, from telepathy to otherworldly perceptions, challenging the limits of what we believe to be real. For years, their parents and teachers have quietly witnessed these remarkable abilities, knowing that the time to share their truth would eventually come. But now, as the evidence mounts, the time has come to reveal what has been hidden in plain sight. This groundbreaking series challenges everything we think we know about communication and the human mind, inviting viewers to step into a reality where the impossible is not only possible but happening every day. Through emotional stories and undeniable evidence, The Telepathy Tapes offers a fresh perspective on the profound connections that exist beyond words. Traveling with neuroscientist Dr. Diane Hennacy Powell, witnessing mind-boggling telepathy tests and forging deeply intimate relationships with families around the globe, host Ky Dickens invites you to contemplate the world through the eyes of those who speak without words. Prepare to be captivated, challenged, and ultimately transformed as the series shines a light on the untold capabilities of those who have been underestimated for far too long." Dr. Powell is a Johns Hopkins-trained psychiatrist, therapist, neuroscientist, and public speaker. She develops multidisciplinary theories towards understanding psychological anomalies, such as savant skills and verified accounts of spacetime navigation. Her current research focuses on controlled testing of autistic savants and children reported to be telepathic and/or precognitive by their caregivers. Dr. Powell has been on the faculty at Harvard Medical School, a member of a think tank on human consciousness at the Salk Institute in La Jolla, California, and Director of Research for the John E. Mack Institute. Her investigation into the neurocorrelates of ESP is discussed in her 2008 book The ESP Enigma: The Scientific Case for Psychic Phenomena, and in Seriously Strange: Thinking Anew about Psychical Experiences. Dr. Powell is also an expert on PTSD and created the psychiatry program for Survivors of Torture, International in San Diego, California. She was the principal author of IONS The 2007 Shift Report: Evidence of a World Transforming and a contributing author to Beyond Forgiveness: Reflections on Atonement, the 2014 Campus Book of the Year at Indiana University. She is also a participant in the #NeverAlone movement for suicide prevention launched by Deepak Chopra. Website: drdianehennacy.com Discussion of this interview in the BatGap Community Facebook Group. First BatGap interview with Dr. Powell Interview recorded March 23, 2025

Being a scientist is a way of looking at the world, and asking the question 'why' without your own pre-conceived notions. I've learned that it's also a great way of doing business. -Julia Wrin Piper How do you go from scientist to CEO? Meet Julia Wrin Piper. She's got degrees in Molecular Biology, Neuroscience, and Evolutionary Biology from UC/Berkeley, the Salk Institute for Biological Sciences, and Harvard University, and she's using years of scientific training to forward the mission of Clover, a Boston-area fast casual chain specializing in local, seasonal sandwiches and bowls. www.cloverfoodlab.com. Clover's mission is to significantly reduce carbon emissions through the creation of delicious, sustainably-sourced, plant-based fast food. Says Julia: “We take beautiful food that people are familiar with, and reinvent it with 100% locally sourced vegetarian ingredients. We want you to love your veggies so much, you dream about them.” Clover's Cambridge-based culinary experts work directly with farmers in the region. Born and raised in California's Bay Area, Julia's mom is a virologist who was at the forefront of HIV research and continued to offer her scientific expertise during the COVID-19 pandemic. Her father was a stay-at-home dad for many years before taking a job as an educator. Now a mother herself, Julia deeply appreciates the home she grew up in: “It was like no other. My mom was my role model, and having my father at home gave us a wonderful and very different perspective. What does the future look like for Clover under Julia's leadership? Chances are, there will be a Clover near you as the company eyes expansion beyond Massachusetts. “Being a scientist is a way of looking at the world, asking the question 'why' without your own pre-conceived notions. I've learned that it's also a great way of doing business. For 23 minutes with a woman who makes science yummy and fun, just hit that download button. #scientist #veggies #climatechange #STEM #local #carbonfootprint

Professor Sara C. Mednick is a cognitive neuroscientist at the University of California, Irvine and author of The Hidden Power of the Downstate (Hachette Go!, pub date: April, 2022) and Take a Nap! Change Your Life. (Workman). She is passionate about understanding how the brain works through her research into sleep and the autonomic nervous system. Dr. Mednick's seven-bedroom sleep lab works literally around-the-clock to discover methods for boosting cognition by napping, stimulating the brain with electricity, sound and light, and pharmacology. Her lab also investigates how the menstrual cycle and aging affect the brain. Her science has been continuously federally funded (National Institute of Health, National Science Foundation, Department of Defense Office of Naval Research, DARPA).Dr. Mednick was awarded the Office Naval Research Young Investigator Award in 2015. Her research findings have been published in such leading scientific journals as Nature Neuroscience and The Proceedings from the National Academy of Science, and covered by all major media outlets. She received a BA from Bard College, Annandale-on-Hudson, NY, in Drama/Dance. After college, her experience working in the psychiatry department at Bellevue Hospital in New York, inspired her to study the brain and how to make humans smarter through better sleep. She received a PhD in Psychology from Harvard University, and then completed a postdoc at the Salk Institute for Biological Studies and UC San Diego. She resides in San Diego, CA. SHOWNOTES:

Diane Hennacy Powell, M.D. is an author, researcher, public speaker and practicing psychiatrist who started as a neuroscientist before obtaining her medical degree and training in medicine, neurology, and psychiatry at Johns Hopkins University. She became a member of Harvard Medical School's faculty and later an original member of the La Jolla Group for Understanding the Origin of Humans, a think tank at the Salk Institute with several world-renowned neuroscientists and Nobel laureates. She has spoken at international conferences such as Towards a Science of Consciousness and the IONS annual conference. Her research findings and hypotheses about the brain and psi are published in her  book,The ESP Enigma: A Scientific Case for Psychic Phenomena.  Her current research focuses on autistic savants. Their abilities are so similar to psychic phenomena that they defy the current paradigm about the brain and consciousness, but unlike psychic abilities, theirs are accepted because they are reproducible. Her current project investigates savants who also report psi.

This episode is brought to you by  Bon Charge and Momentous. We used to think circadian rhythm only applied to sleep. But emerging science has revealed a link between our circadian rhythm and metabolism, cognition, risk for chronic diseases, and many other crucial aspects of our health. Our biology was designed to live in sync with a natural light-dark cycle, but modern-day society has disrupted this natural balance.  Today on The Dhru Purohit Show, we're revisiting one of our favorite episodes with Dr. Satchin Panda. Dr. Panda dives deep into his groundbreaking circadian biology research and shares how leveraging your circadian rhythm can dramatically improve your sleep, lower your risk of chronic disease, and improve your cognitive function. They also discuss how time-restricted eating, exercise, and light can be used to help program your circadian rhythm and why it's especially important for shift workers to take advantage of these tools.  Dr. Panda is pioneering circadian biology research. He is a professor at the Salk Institute for Biological Studies, a Pew Biomedical Scholar, founder of the UC San Diego Center for Circadian Biology, and recipient of the Julie Martin Mid-Career Award in Aging Research. Dr. Panda has spoken at conferences around the world about his work on circadian rhythms and diabetes, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the professional diabetes societies of Europe and Australia. In this episode, Dhru and Dr. Panda dive into: Why late-night eating is so detrimental to our health (2:15) Organ systems that have a circadian rhythm (8:24) Common ailments that could be related to circadian rhythm disturbances (14:11) Night-shift work and cancer risk (20:19) How poor sleep perpetuates bad food choices (27:00) What happens in the body when you rely on an alarm clock (44:01) Why you need to accumulate sleep debt for better sleep (51:25) Time-restricted eating and sleep (1:00:40) How to combat fragmented sleep (1:15:35) The best time to work out (1:55:50) The link between exercise and cancer (2:07:55) Positive changes for better sleep health on a global scale (2:17:20) Strategies for night-shift workers to combat circadian rhythm disruption 02:45:10) Dr. Panda's research in firefighters (2:48:46) Tips for optimizing your circadian rhythm (3:14:20) Where to follow and support Dr. Panda's work (3:27:50) Also mentioned in this episode: The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight The Circadian Diabetes Code: Discover the Right Time to Eat, Sleep, and Exercise to Prevent and Reverse Prediabetes and Diabetes Download the MyCircadianClock app Try This: 6 Crazy Facts About Sleep Try This: How Exercise Helps Fight Cancer For more on Dr. Satchin Panda, follow him on Twitter @SatchinPanda, Instagram @satchin.panda, or his Website. This episode is brought to you by Bon Charge and Momentous. Right now, BON CHARGE is offering my community 15% off; just go to boncharge.com/DHRU and use coupon code DHRU to save 15%. Optimize your energy and mental clarity with the Momentous Three: Protein, Omega-3s, and Creatine made by and used by the best. Go to livemomentous.com and enter promo code DHRU to get 20% off any order.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Things are changing in Alzheimer's research. We've got new tools and new ideas, and we want you to know about them. To kick off Salk's “Year of Alzheimer's,” hear how our scientists are bringing us closer to a more modern and personalized landscape of Alzheimer's diagnosis, treatment, and prevention.

Today we have a very special episode. Visit California invited us out of our New York City studio and over to the West Coast for a food-focused road trip around San Diego and North County, including stops in Carlsbad and Oceanside. We start our journey at the source at the legendary Chino Farm, where three generations of Japanese American Chinos have been growing incredible produce used by chefs throughout California. Our next stop is a visit with Jeff Lozano, a brand ambassador at San Diego's Ballast Point Brewing, one of the foundational craft beer makers in a city famous for its great beer. The journey then heads up Interstate 5 to Carlsbad, where we catch up with Eric Bost, a prolific chef behind the newly opened Wildland and the soon-to-open tasting menu restaurant Lilo. To close, Aliza and Matt share many more discoveries from their road trip around Southern California.More places we visited: Rare Society, City Tacos, Tribute Pizza, Wayfarer Bread, Aisu Creamery, Little Fox Cups and Cones, Wrench & Rodent. You can visit the Salk Institute for Biological Studies by reserving a spot on a weekly docent-led tour. And some great hotels to keep in mind: Catamaran Resort Hotel and Spa and the Omni La Costa Resort & Spa.To donate to California wildfire relief, visit Restaurants Care. This very special episode of This Is TASTE is supported by Visit California. While this episode was recorded before the LA wildfires in January, all of the restaurants featured are open for business, and we can't think of a better time to pay California a visit for your own food-obsessed road trip. Dining out in LA is one way to help support the city, and these truly were some amazing places. Questions about visiting LA now?See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neurons have long enjoyed a kind of rock star status. We think of them as the most fundamental units of the brain—the active cells at the heart of brain function and, ultimately, at the heart of behavior, learning, and more. But neurons are only part of the story—about half the story, it turns out. The other half of the brain is made up of cells called glia. Glia were long thought to be important structurally but not particularly exciting—basically stage-hands there to support the work of the neurons. But in recent decades, at least among neuroscientists, that view has faded. In our understanding of the brain, glia have gone from stage-hands to co-stars.   My guest today is Dr. Nicola Allen. Nicola is a molecular neuroscientist and Associate Professor at the Salk Institute in La Jolla, California. She and her lab study the role of glial cells—especially astrocytes—in brain function and dysfunction.   Here, Nicola and I talk about how our understanding and appreciation of glial cells has changed. We do a bit of Brain Cells 101, reviewing the main division between neurons and glia and then sketching the subtypes within each category. We discuss the different shapes and sizes of glial cells, as well as the different functions. Glia are an industrious bunch. They're involved in synapse formation and pruning, the production of myelin, the repair of injuries, and more. We also talk about how glial cells have been implicated in various forms of brain dysfunction, from neurodegeneration to neurodevelopmental syndromes. And how, as a result, these cells are attracting serious attention as a site for therapeutic intervention.   Well, it's that time of year again folks. Applications are now open for the 2025 Diverse Intelligences Summer Institute, or DISI. This is an intense program—highly interdisciplinary, highly international—for scholars and storytellers interested in all forms and facets of intelligence. If you like thinking about minds, if you like thinking about humans and animals and plants and AIs and collectives and ways they're alike and different—you would probably like DISI. For more info, check out disi.org—that's D-I-S-I dot org. Review of applications begins March 1st, so don't dally too too long.   Alright friends—on to my conversation with Dr. Nicola Allen. Enjoy!   Notes and links 3:00 – Correction: “glia” actually comes from the Greek—not the Latin—for “glue.” 3:30 – See this short primer on glia by Dr. Allen and Dr. Ben Barres. For a bit of the history of how glial cells were originally conceived, see this article on Ramón y Cajal's contributions to glia research. 10:00 – On the nascent field of “neuroimmunology,” see here. 14:00 – On the idea that “90% of brain cells are glia” see this article by (former guest) Suzana Herculano-Houzel. 18:00 – The root “oligo” in “oligodendrocyte” means “few” (and is thus the same as the “olig” in, e.g., “oligarchy"). It is not related to the “liga-” in “ligament.” 28:00 – On the idea that the glia-neuron ratio changes as brains grow more complex, see again the article by Dr. Herculano-Houzel. 30:00 – See Dr. Allen's paper on the idea of glia as “architects.” See also Dr. Allen's paper on the idea of glia as “sculptors.” 33:00 – See Dr. Allen's paper on the idea of the “tripartite synapse.” 42:00 – A recent paper reviewing the phenomenon of adult neurogenesis.  48:00 –  See Dr. Allen's recent review of the role of astrocytes in neurodegeneration. 51:30 – A recent article on the roles of APOE in Alzheimer's.   Recommendations Glia (2nd edition), edited by Beth Stevens, Kelly R. Monk, and Marc R. Freeman   Many Minds is a project of the Diverse Intelligences Summer Institute, which is made possible by a generous grant from the John Templeton Foundation to Indiana University. The show is hosted and produced by Kensy Cooperrider, with help from Assistant Producer Urte Laukaityte and with creative support from DISI Directors Erica Cartmill and Jacob Foster. Our artwork is by Ben Oldroyd. Our transcripts are created by Sarah Dopierala.   Subscribe to Many Minds on Apple, Stitcher, Spotify, Pocket Casts, Google Play, or wherever you listen to podcasts. You can also now subscribe to the Many Minds newsletter here! We welcome your comments, questions, and suggestions. Feel free to email us at: manymindspodcast@gmail.com.    For updates about the show, visit our website or follow us on Twitter (@ManyMindsPod) or Bluesky (@manymindspod.bsky.social).

This episode is brought to you by Pique Life and Birch Living.  We used to think that the circadian rhythm only affected sleep. However, emerging science shows it's deeply connected to metabolism, cognition, chronic disease risk, and many other critical aspects of health. Our biology is designed to function in harmony with the natural light-dark cycle, but modern society has significantly disrupted this balance. Today on The Dhru Purohit Show, we bring you a special compilation episode featuring Dhru's conversations with leading experts on the critical role circadian rhythms play in our health and well-being. Dr. Satchin Panda delves into his groundbreaking research on circadian biology, revealing how leveraging your circadian rhythm can significantly improve sleep, reduce the risk of chronic diseases, and enhance cognitive function. He also shares how time-restricted eating, exercise, and light exposure can help program your circadian rhythm, with a special focus on the importance of these tools for shift workers. Dr. Moore-Ede discusses the dangers of chronic blue light exposure and its profound impact on health, highlighting research that reveals how it disrupts circadian rhythms. He also examines the connection between light exposure and obesity and explains why these risks remain underrepresented in mainstream media. Dr. Satchin Panda, a professor at the Salk Institute and founder of the UC San Diego Center for Circadian Biology, is a leading researcher in circadian biology. Dr. Martin Moore-Ede, a former Harvard Medical School professor and expert in circadian rhythms, has conducted groundbreaking research on light's role in regulating sleep-wake cycles and overall health. In this episode, Dhru and his guests dive into: Why when we eat is more important than what we eat (01:38) Effects of chronic late-night eating (08:18) Adverse effect of disrupting our circadian rhythm (16:25) What is sleep debt (19:21) Paying attention to when you eat (30:16) Research on time-restricted eating (34:08) Why sleeping with the lights on is damaging to your health (39:01) Why sun exposure is critical for good health (41:55) Dr. Martin's recommended time for sun exposure (49:28) The link between blue light and obesity (51:42) Master clock of the circadian rhythm, cortisol, melatonin, and others (54:06) Why doctors aren't talking about the harmful effects of blue lights (59:03) Blue lights in hospitals and how they prevent healing (01:04:47) Also mentioned: Full episode with Dr. Satchin Panda Full episode with Dr. Martin Ede-Moore This episode is brought to you by Pique Life and Birch Living.  Right now, Pique Life is offering 15% off the Radiant Skin Duo plus a free beaker and frother when you go to piquelife.com/dhru. To get 25% off your Birch Living mattress plus two free eco-rest pillows, head over to birchliving.com/dhru today. Learn more about your ad choices. Visit megaphone.fm/adchoices

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There are more potential moves on a Go board than there are atoms in the universe; the game is universally considered to be one of the most complex played by humans. And, yet, an AI computer program can play it perfectly. What does that mean for humanity? Terry Sejnowski is the Frances Crick Chair at the Salk Institute for Biological Studies, a Distinguished Professor at the University of San Diego, and author of the book “ChatGPT and The Future of AI.” Ricky Mulvey caught up with Sejnowski for a conversation about: - How chatbots work. - Mapping large neural models. - What a self-aware parrot can teach us about human consciousness. Premium Motley Fool members can catch replays from this week's AI Summit here: https://www.fool.com/premium/4056/coverage/2025/01/15/ai-summit-replay To become a premium Motley Fool member, go to www.fool.com/signup Host: Ricky Mulvey Guest: Terrence Sejnowski Producer: Mary Long Engineer: Rick Engdahl Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of Remarkable People, Guy Kawasaki engages in a fascinating dialogue with Terry Sejnowski, the Francis Crick Chair at the Salk Institute and Distinguished Professor at UC San Diego. Together, they unpack the mysteries of artificial intelligence, exploring how AI mirrors human learning in unexpected ways. Sejnowski shatters common misconceptions about large language models while sharing compelling insights about their potential to augment human capabilities. Discover why being polite to AI might yield better results and why the future of AI is less about academic debates and more about practical applications that can transform our world.---Guy Kawasaki is on a mission to make you remarkable. His Remarkable People podcast features interviews with remarkable people such as Jane Goodall, Marc Benioff, Woz, Kristi Yamaguchi, and Bob Cialdini. Every episode will make you more remarkable.With his decades of experience in Silicon Valley as a Venture Capitalist and advisor to the top entrepreneurs in the world, Guy's questions come from a place of curiosity and passion for technology, start-ups, entrepreneurship, and marketing. If you love society and culture, documentaries, and business podcasts, take a second to follow Remarkable People.Listeners of the Remarkable People podcast will learn from some of the most successful people in the world with practical tips and inspiring stories that will help you be more remarkable.Episodes of Remarkable People organized by topic: https://bit.ly/rptopologyListen to Remarkable People here: **https://podcasts.apple.com/us/podcast/guy-kawasakis-remarkable-people/id1483081827**Like this show? Please leave us a review -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!Thank you for your support; it helps the show!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Artificial intelligence is rapidly transforming business, technology, and society. On this episode of CXO Talk, Dr. Terrence Sejnowski, a renowned computational neuroscientist, deep learning pioneer, and author of "ChatGPT and the Future of AI," discusses the implications of this technological revolution. He explores how AI is evolving, drawing parallels with the human brain, and explains why a robust data strategy is crucial for successful AI implementation. Dr. Sejnowski holds the Francis Crick Chair at the Salk Institute for Biological Studies and is a Distinguished Professor at UC San Diego. Dr. Sejnowski explains the importance of lifelong learning for employees and emphasizes AI's role in augmenting, not replacing, human capabilities. He also addresses critical topics such as explainability in AI decision-making, ethical considerations, and the potential impact of AI on the future of work. This discussion offers practical guidance for business and technology leaders navigating the complexities of AI integration and its implications for their organizations. Episode Participants Terrence J. Sejnowski is Francis Crick Chair at The Salk Institute for Biological Studies and Distinguished Professor at the University of California at San Diego. He has published over 500 scientific papers and 12 books, including ChatGPT and The Future of AI: The Deep Language Learning Revolution. He was instrumental in shaping the BRAIN Initiative that was announced by the White House in 2013, and he received the prestigious Gruber Prize in Neuroscience in 2022 and the Brain Prize in 2024. Sejnowski was also a pioneer in developing learning algorithms for neural networks in the 1980s, inventing the Boltzmann machine with Geoffrey Hinton; this was the first learning algorithm for multilayer neural networks and laid the foundation for deep learning. He is the President of the Neural Information Processing Systems (NeurIPS) Foundation, which organizes the largest AI conference, and he is a leader in the recent convergence between neuroscience and AI. Michael Krigsman is a globally recognized analyst, strategic advisor, and industry commentator known for his deep expertise in digital transformation, innovation, and leadership. He has presented at industry events worldwide and written extensively on the reasons for IT failures. His work has been referenced in the media over 1,000 times and in more than 50 books and journal articles; his commentary on technology trends and business strategy reaches a global audience. #AI #ArtificialIntelligence #FutureofWork #DeepLearning #CXO #DigitalTransformation #BusinessStrategy #TechnologyLeadership #ChatGPT #cxotalk

In this episode, my guest is Dr. Terry Sejnowski, Ph.D., professor of computational neurobiology at the Salk Institute for Biological Studies. He is world-renowned for exploring how our brain processes and stores information and, with that understanding, for developing tools that enable us to markedly improve our ability to learn all types of information and skills. We discuss how to learn most effectively in order to truly master a subject or skill. Dr. Sejnowski explains how to use AI tools to forage for new information, generate ideas, predict the future, and assist in analyzing health data and making health-related decisions. We also explore non-AI strategies to enhance learning and creativity, including how specific types of exercise can improve mitochondrial function and cognitive performance. Listeners will gain insights into how computational methods and AI are transforming our understanding of brain function, learning, and memory, as well as the emerging roles of these tools in addressing personal health and treating brain diseases such as Alzheimer's and Parkinson's. Access the full show notes for this episode at hubermanlab.com. Pre-order Andrew's new book, Protocols: protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman  David Protein: https://davidprotein.com/huberman  LMNT: https://drinklmnt.com/huberman  Joovv: https://joovv.com/huberman  Timestamps 00:00:00 Dr. Terry Sejnowski   00:02:32 Sponsors: BetterHelp & Helix Sleep   00:05:19 Brain Structure & Function, Algorithmic Level   00:11:49 Basal Ganglia; Learning & Value Function   00:15:23 Value Function, Reward & Punishment   00:19:14 Cognitive vs. Procedural Learning, Active Learning, AI   00:25:56 Learning & Brain Storage   00:30:08 Traveling Waves, Sleep Spindles, Memory   00:32:08 Sponsors: AG1 & David   00:34:57 Tool: Increase Sleep Spindles; Memory, Ambien; Prescription Drugs   00:42:02 Psilocybin, Brain Connectivity   00:45:58 Tool: ‘Learning How to Learn' Course   00:49:36 Learning, Generational Differences, Technology, Social Media   00:58:37 Sponsors: LMNT & Joovv   01:01:06 Draining Experiences, AI & Social Media   01:06:52 Vigor & Aging, Continued Learning, Tool: Exercise & Mitochondrial Function   01:12:17 Tool: Cognitive Velocity; Quick Stressors, Mitochondria   01:16:58 AI, Imagined Futures, Possibilities   01:27:14 AI & Mapping Potential Options, Schizophrenia   01:30:56 Schizophrenia, Ketamine, Depression   01:36:15 AI, “Idea Pump,” Analyzing Research   01:42:11 AI, Medicine & Diagnostic Tool; Predicting Outcomes   01:50:04 Parkinson's Disease; Cognitive Velocity & Variables; Amphetamines   01:59:49 Free Will; Large Language Model (LLM), Personalities & Learning   02:12:40 Tool: Idea Generation, Mind Wandering, Learning   02:18:18 Dreams, Unconscious, Types of Dreams   02:22:56 Future Projects, Brain & Self-Attention   02:31:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter   Disclaimer & Disclosures

When it comes to weight management and all-around good metabolic health, we most often think about what to eat. But my guest would say that it's also crucial to think about when to eat,Emily Manoogian is a chronobiologist and clinical researcher at the Salk Institute for Biological Studies. Today on the show, Emily shares how to create an optimal schedule for a healthy metabolism by aligning your eating schedule with your circadian rhythm. She explains when to start eating after waking, when to stop eating before bed, the importance of sticking to a set schedule, and what happens to your metabolism when you don't follow these timing guidelines. We also talk about how to best distribute your calorie intake throughout the day and how to eat to mitigate the metabolic problems that come with being a shift worker.Resources Related to the PodcastThe Salk InstituteMy Circadian Clock appAoM Podcast #1,016: Unlock Better Sleep and Health by Harnessing Your Circadian RhythmConnect with Emily ManoogianEmily on LinkedInEmily on X

How should we go about understanding LLMs? Do these language models truly understand what they are saying? Or is it possible that what appears to be intelligence in LLMs may be a mirror that merely reflects the intelligence of the human observer? In this episode, Terry Sejnowski explores the history and future of AI and its profound implications for understanding the human mind. He explains AI's evolution from early logic-based systems to cutting-edge advancements like deep learning and large language models, including ChatGPT, emphasizing the need for clear operational definitions and a strong mathematical foundation to advance AI research. Sejnowski also highlights the parallels between scientific discovery and engineering, discussing practical applications of AI in areas such as language translation and weather prediction. Terry Sejnowski is the Francis Crick Chair at The Salk Institute for Biological Studies and a Distinguished Professor at the University of California, San Diego. He has published over 500 scientific papers and 12 books, including ChatGPT and The Future of AI: The Deep Language Revolution.

Join us for an episode tackling some of the tougher conversations that need to be had - the ones that take up space, the ones that are the elephant in the room, and the ones that require grit. Erika welcomes guest Alreen Haeggquist - a sex abuse survivor - as she shares her deeply personal story of childhood abuse and the steps she's taken to overcome the long-lasting effectsAlreen founded her own law firm, Haeggquist & ECK LLP which has helped hundreds of other women stand up for themselves. She have challenged high-profile entities including The Salk Institute, Trader Joe's, Kaiser Permanente, the San Diego Sheriff‘s Department, and a President-elect.Erika and Alreen open up about some of the most challenging circumstances they've ever had to overcome and how they have harnessed these experiences to make them who they are today. Together, they deliver what it means to summon the grit to come out stronger on the other side. Connect with Alreen:https://www.alreen.com/Connect with your host, Erika:LinkedIn (primary)https://www.linkedin.com/in/erikarothenbergerIGhttps://www.instagram.com/erikalearothenberger?igsh=MmhjeTRhbnB1aXM2FBhttps://www.facebook.com/share/69wqEYVzFKKnci9u/?mibextid=LQQJ4d

Ever wondered why some people seem to age faster while others barely slow down? Unpack the 12 hallmarks of aging, highlighting how hidden factors like inflammation & genomic instability could be sabotaging your health. But here's the good news: by adopting core lifestyle habits & understanding how supplementation really works, you'll take control of your aging process. With Chris Mirabile of Novos Labs, you'll gain insights from the largest database of longevity enhancing practices & how to fine-tune your routine for a longer, healthier life. Dive into all that & more in today's episode on ‘Novos Labs Longevity' Meet our guest Chris Mirabile is a serial entrepreneur, brain tumor survivor, & the youngest winner of NYU Stern's business plan competition. He co-founded multiple successful startups, including a real estate tech platform serving clients with over half a trillion USD in assets & Hotlist, a social platform that attracted interest from Google & Facebook. Driven by his passion for health & wellness, Chris turned his focus to longevity after surviving a brain tumor. As a “citizen scientist,” he spent over a decade researching aging & experimenting with lifestyle hacks. This journey led him to found NOVOS, the first nutraceutical company targeting the 12 biological causes of aging. NOVOS features a scientific advisory board with top biologists & geneticists from Harvard, MIT, & The Salk Institute, creating a biotech platform that empowers people to enhance their healthspan & lifespan. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Most supplement companies are primarily marketing-focused, not scientific or biotech-driven Combining ingredients can produce unexpected effects on the body Scientific studies should validate whether ingredient combinations are synergistic, rather than relying on marketing assumptions Negative synergy (dyssynergy) occurs when a combination of ingredients makes the result worse Feeling younger or looking better from HGH doesn't guarantee long-term health; it may actually be harmful Some antioxidants act as pro-oxidants, leading to an increase in the body's own antioxidants While you may feel a product works, negative biological effects might occur unnoticed Phosphatidyl inositol helps with stress & may benefit women with severe menstruation or hormonal issues About 70% of people are deficient in magnesium The supplement is designed for both biohackers & the average American, not just for obese individuals Tterastylabine is better absorbed through the gut & has a longer half-life in the blood than resveratrol, making it more effective Episode Highlights 06:23 Understanding The Truth About Longevity 17:07 What You Need to Know About Longevity Supplements 35:12 Behind The World's Largest Longevity Database 45:16 Longevity Practices To Start Your Journey Links Watch it on YouTube: https://youtu.be/CrcktKY9GlE  Full episode show notes: mindbodypeak.com/177 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Stat: 13%: The average five-year survival rate for pancreatic cancer patients in 2024, according to the American Cancer Society. This is compared to a 90% average five-year survival rate for people diagnosed with breast cancer. Story: Scientists have made tremendous progress on cancer research to improve patient survival rates. But challenges still exist because some cancers can suddenly become unaffected by treatment.  In this episode, Christina Towers, a cancer cell biologist from the Salk Institute for Biological Studies, explains how cancer cells can adapt their metabolic processes—through a mechanism she studies called autophagy—to resist drug therapies. She discusses how her research studying this process could lead to new approaches to prevent and control a cancer's resistance to treatment—and, ultimately, save lives. And as the first Black faculty member at Salk, Towers shares how her mantra, “Honored to be first but refuse to be the last,” guides her efforts to increase diversity across the scientific community. 

Satchidananda (Satchin) Panda, PhD discusses the impact of food timing on health, advocating for personalized eating windows and gradual changes to fasting routines. Dr. Panda and Dr. Mindy explore the relationship between fasting, metabolic health, and gut microbes, emphasizing the importance of lifestyle factors like sleep, exercise, and diverse gut microbiota for overall well-being. Dr. Panda shares tips on adjusting to different time zones to support metabolic health during travel, highlighting the holistic approach to health through healthy daily routines. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep236 Satchidananda (Satchin) Panda, PhD is a Professor at the Salk Institute in California, where his research focuses on the circadian regulation of behavior, physiology, and metabolism in model organisms and in humans. Dr. Panda discovered a blue-light sensing cell type in the retina entrains our master circadian clock, affects mood, and regulates the production of the sleep hormone melatonin. Recently, he discovered that maintaining a daily feeding-fasting cycle – popularly known as time-restricted feeding (TRF) – can prevent and reverse metabolic diseases. Based on a feasibility study in humans, his lab is currently carrying out a smartphone-based study to assess the extent of circadian disruption among adults. Dr. Panda has received the Julie Martin Mid-Career Award in Aging Research, the Dana Foundation Award in Brain and Immune System Imaging, and was a Pew Scholar in the Biomedical Sciences   Check out our fasting membership at resetacademy.drmindypelz.com. Please note our medical disclaimer.

In this episode, my guest is Dr. Kay Tye, PhD, Professor of Systems Neurobiology at the Salk Institute for Biological Studies and a Howard Hughes Medical Institute (HHMI) Investigator. We discuss the neural circuit basis of social interactions and loneliness. We also discuss how animals and people establish themselves in a group hierarchy by rank and how the brain responds to dominance and subordination. Much of our discussion relates to how social media impacts our sense of social connectedness or lack thereof. The topics covered in this episode are directly relevant to anyone interested in the neuroscience of mental health, work-life balance, abundance versus scarcity mindset, and interpersonal dynamics. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Levels: https://levels.link/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Kay Tye (00:02:39) Sponsors: Eight Sleep, Levels & LMNT (00:06:40) Amygdala; “Valence” (00:12:43) Novelty; Reward & Punishment Response (00:20:06) Amygdala & Hunger; Social Interaction (00:26:21) Social Media & Social Connection; Tool: Email & Time Management (00:35:03) Sponsor: AG1 (00:36:30) Social Media; Friction & Feedback, Leadership (00:43:44) Social Isolation, Harlow Experiments, “Loneliness Neurons” (00:51:47) Social Homeostasis, COVID-19 Pandemic & Loneliness (01:01:29) Quality of Social Contact, Social Homeostasis, Social Media (01:08:40) Sponsor: InsideTracker (01:09:42) Social Media, Relationships; Social Isolation & Exclusion (01:18:26) Empathy: Friend vs. Foe (01:28:40) Background & Empathy, Diversity, Emotional Regulation (01:34:34) Abundance vs. Scarcity Mindset (01:37:22) Social Rank & Hierarchy, Sibling Order, Development (01:45:54) Dynamic Hierarchy; Dominants vs. Subordinates; Mentors (01:55:32) Psychedelics: Research & Mechanisms; Psilocybin (02:06:28) Work-Life Balance, Fitness & Extracurriculars (02:11:56) Personal Life, Diversity, Happiness; Typical Day (02:15:42) Science & Academia; Future Directions (02:23:48) Research & Science Outreach (02:28:48) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer