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Nutrition Nugget! Bite-sized bonus episodes offer tips, tricks and approachable science. This week, Jenn is talking about Food Allergy Prevention, a groundbreaking new study from the Salk Institute that could change everything we thought we knew about food allergies. What if having no allergic reaction is not just luck but an active, complex process happening inside your body? New findings point to specific immune cells in the gut that may hold the key to why some people can eat anything without a reaction while others cannot. Could something as simple as what you feed a child early in life shift the odds in their favor? Jenn breaks down the science, the caveats, and what this might actually mean for families navigating the very real challenges of food allergies. Is a future without food allergies possible? You might be surprised by what the research is starting to reveal. Like what you're hearing? Be sure to check out the full-length episodes of new releases every Wednesday. Have an idea for a nutrition nugget? Submit it here: https://asaladwithasideoffries.com/index.php/contact/ RESOURCES:Become a Happy Healthy Hub MemberJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramKEYWORDS: Jenn Trepeck, Nutrition Nugget, Salad With A Side Of Fries, Health Tips, Wellness Tips, Food Allergies, Immune System, Regulatory T Cells, Treg Cells, Oral Tolerance, Gut Health, Food Intolerance, Allergy Research, Immunotherapy, Plant Proteins, Wheat Allergy, Soy Allergy, Peanut Allergy, Egg Allergy, Corn Proteins, Immune Response, Inflammation, Anti-Inflammatory, Gut Microbiome, Pediatric Allergies, Allergy Treatment, Food Sensitivity, Immune Tolerance, Salk Institute, Science Immunology, Stanford Research, Diet And Health, Nutrition Science, Epitopes, Peacekeeper Cells, Allergy Prevention In Children, Early Food Exposure, Allergen Introduction, Immune Cell Function, Cell Culture Research, Gut Inflammation, Healthy Immune Function, Nutritional Immunology, Wellness Research, Functional Nutrition, How To Prevent Food Allergies In Children, Early Allergen Exposure And Immune Tolerance
A fly with 100,000 neurons can fly, find food, and reproduce. A $100 million supercomputer cannot. Dr. Terry Sejnowski used that observation to silence a room full of MIT AI researchers in the 1980s, and it remains just as sharp today. Sejnowski is one of the foundational figures in the history of deep learning, co-inventor of the Boltzmann machine, and a professor at the Salk Institute who has spent his career studying both the brain and the machines we build to imitate it. In this conversation with Craig Smith, he turns that dual perspective on ChatGPT, and what he finds is something genuinely clarifying: not a human mind, not a threat to humanity, but an alien intelligence that has absorbed more knowledge than any brain ever could while remaining fundamentally empty when nobody is talking to it. The conversation covers the full landscape of what current AI is missing - from goals and reinforcement learning to the constant self-generated flow of thought that defines consciousness - and why the word "understanding" is so ambiguous that even the world's top cognitive scientists can't agree on whether ChatGPT has it. Sejnowski also makes the case that hallucinations aren't a flaw to be engineered away but the flip side of creativity itself, that we are in a pre-Copernican era when it comes to understanding intelligence, and that the real future of AI lies not in scaling language models further but in looking at what nature has already solved, from field mice to fruit flies. His new book is written for the general public and available now. Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.
Effizienter Lernen - Arbeiten - Leben! Der Selbstmanagement und Zeitmanagement Podcast!
Stell dir vor, du wärst Profisportler: Dein Schlaf wird optimiert, deine Regeneration wissenschaftlich betreut – alles für Höchstleistungen. Doch wie sieht es bei uns Knowledge Workern mit unserer wichtigsten Ressource, dem Gehirn, aus? Die meisten von uns optimieren Ernährung und Arbeitsabläufe, vergessen aber das Organ, das alles steuert. 2026 soll der Wendepunkt für mentale Fitness werden – das Salk Institute ruft sogar das Jahr der Gehirngesundheit aus. In dieser Episode zeigt dir Thomas Mangold, welche drei wissenschaftlich fundierten Hebel du sofort nutzen kannst, um deine mentale Leistungsfähigkeit nachhaltig zu steigern – ganz ohne Supplements oder Hypes. Erfahre, warum Schlaf viel mehr ist als nur „ausreichend Schlaf“, wie Bewegungsmuster dein Hirn pushen und wie strategische Pausen dich wirklich voranbringen. Lass dich inspirieren, deinen Alltag gehirngesund und leistungsstark zu gestalten! **Hier geht es zum Werbepartner dieser Podcast-Folge**: https://selbst-management.biz/podcast-partner Links: - Kostenloser Mangold-Academy Bonus-Bereich: https://my.mangold.academy/anmeldung-vip-bereich-2/ - Goodie des Monats: https://my.mangold.academy/courses/einstieg-in-das-selbstmanagement/lessons/goodie-des-monats/ - SelbstmanagementRocks Masterclass: https://selbst-management.biz/selbstmanagement-rocks-masterclass/ - Mein LinkedIn Profil: https://www.linkedin.com/in/thomasmangold/
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/biography
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/education
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today I'm speaking with William R. Brody about his book, Uncommon Sense: Rethinking Ordinary Problems in Extraordinary Ways (Johns Hopkins University Press, 2026). Bill is an interventional radiologist who served as the President of Johns Hopkins University, from 1996 to 2009, and President of the Salk Institute from 2009 to 2015. When he became president of Johns Hopkins University, Bill set out to teach a course to juniors and seniors that would serve as a crash course for dealing with the messy realities of life. Through stories and anecdotes, Bill explores a variety of important concepts that regularly manifest in all aspects of life: from survivorship bias to why career-planning doesn't often go as planned. Uncommon Sense is one of those books that one can only write after a lifetime of learning, teaching, and doing. Caleb Zakarin is the CEO and Publisher of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Livin' in San Diego Podcast, Chris and Cassidy sit down with San Diego tech founder Hud Taylor at our new Carlsbad studio.Hud shares his unique journey from growing up in El Centro to studying biochemistry at UC San Diego and doing research at the Salk Institute before transitioning into tech entrepreneurship.We dive into how Hud built TrashAlert, a free app that helps millions of people track their trash pickup days, along with several other AI-driven tools he's developing. He also talks about his AI assistant “Daisy,” which helps manage operations across multiple projects, and how he uses what he calls “vibe coding” to build apps quickly.We also talk about the rapidly evolving AI landscape, how individuals can use AI as a competitive advantage, and why San Diego continues to be an incredible place for innovation and lifestyle.Topics we cover:Hud's path from science to tech startupsBuilding TrashAlert and solving a local San Diego problemRunning multiple AI projects with an AI assistantThe future of AI tools and entrepreneurshipHidden San Diego spots and why the region inspires innovationIf you enjoy conversations about San Diego tech, startups, AI, and local innovation, this one's for you.
Buckle up, because this episode is raw, real, and bursting with passion! We're diving into everything from the chaos of green room antics, epic Olympic hockey battles, to celebrating black architects who changed the game. If you crave authenticity, unmasking stories, and bold takes — this one's for you. Get ready to feel, reflect, and be inspired!In this episode The unfiltered reality of recording mishaps and green room chaosHow Canada and the US hockey teams threw down in breathtaking Olympic battlesThe overlooked legacy of legendary architect Paul Revere WilliamsFlavors, fumbles, and the unending love for coffee and communityCelebrating trailblazers in architecture, history, and black excellenceThe power of stories, remembrance, and giving flowers while we're hereBreaking down the intersection of sports, architecture, and cultural legacy with bold honestyTimestamps: 00:00 - Chaos, coffee, and the truth behind green room dishevelment 04:33 - How Canadian sports culture shapes the world's view 12:10 - Men's Olympic hockey: the historic comeback and its bittersweet ending 14:27 - Flavor Flav's bold support for US women's teams — more than hype! 17:53 - Celebrating 195 episodes — reflections, laughs, and imagining what's next 21:44 - The art of the perfect coffee — the close calls, the favorites, and the flavor of failure 26:55 - The rise of Puerto Rican coffee stories and small-batch roasters worth knowing 38:19 - Remembering legends, recognizing greatness, and capturing stories on the edge of history 50:13 - Looking ahead: plans for California adventures, the Salk Institute tour, and Texas dreams 52:00 - Wrap-up: what's next, the importance of authentic connections, and never forgetting to celebrate lifeResources & Links:Paul Revere Williams on WikipediaSalk Institute Official WebsiteBlack Architects TrailblazersTwin Peaks SoundtrackFlavor Flav on TwitterCoffee Roaster in Puerto RicoAI National Conference 2024Send Feedback :) Support the showBuy some Coffee! Support the Show!https://ko-fi.com/coffeesketchpodcast/shopOur LinksFollow Jamie on Instagram - https://www.instagram.com/falloutstudio/ Follow Kurt on Instagram - https://www.instagram.com/kurtneiswender/ Kurt's Practice - https://www.instagram.com/urbancolabarchitecture/ Coffee Sketch on Twitter - https://twitter.com/coffeesketch Jamie on Twitter - https://twitter.com/falloutstudio Kurt on Twitter - https://twitter.com/kurtneiswender
K-12 students, educators share how they are using artificial intelligence in the classroom No matter where you went to school, there is one task that has united most of us in misery — homework. Perhaps you remember staying up all night writing an essay on a Shakespeare play that you, of course, waited until the last minute to read. Or maybe you remember those grueling hours at the dinner table, as a parent helped with impossible algebra homework. Today's students have a different tool to help with their assignments — artificial intelligence. A report from the digital rights nonprofit Center for Democracy and Technology last year found 85% of teachers and 86% of students reported using AI in the classroom. Students can now use AI to summarize complicated texts and even write entire essays for them. They can type a math problem or chemistry equation into Chat GPT or Gemini and have it solved instantly, no hour-long sessions with a parent needed. Educators and parents have mixed feelings about the prevalence of artificial intelligence in the classroom. It's even prompted the Ohio Department of Education and Workforce to require all public K-12 school districts to adopt official AI policies by July. But what do high schoolers think about AI? How is it shaping their learning and outlook of their futures? Reporter Anna Huntsman has been traveling to schools in Northeast Ohio to find the answer to that question, and she'll share what she's learned on Tuesday's “Sound of Ideas,” as part of our week-long series, Ideastream Explores: Artificial Intelligence. Artificial intelligence pioneer discusses the origins of machine learning Later in the hour, early research in artificial intelligence used the human brain as a model for building machines that could understand language — today's large language models, or LLM's. Computational neuroscientist Dr. Terrence Sejnowski at the Salk Institute in San Diego is a pioneer in the field. He spoke with Ideastream's Jeff St. Clair about the links between humans and artificial intelligence and the push to build even smarter machines. Guests: - Lauren Angelone, Ph.D., Associate Professor of Science Education and Instructional Technology, Xavier University - Joseph South, Ph.D., Chief Innovation Officer, ISTE + ASCD - Adam Lockwood, Ph.D., Associate Professor of School Psychology, Kent State University - Terrence Sejnowski, Ph.D., Author, "ChatGPT and the Future of AI" - Anna Huntsman, Reporter, Ideastream Public Media - Jeff St. Clair, Midday Host, Ideastream Public Media
Happy 2026! On Humans has typically marked the coming of January by revisiting the previous year's most popular episode. This time, the New Year special packs the five-hour-long "Origins of Humankind" series into one fast-paced dive through deep time.By mixing highlights from the original interviews with fresh narration, this episode offers a captivating journey through many of the great topics around human origins, such as:Who were the first primates The role of fruits, snakes, and predators The human solution to dangerHow to grow a human brain?What did our ancestors eat?Effects of our upright posture Origins of music & language How Homo sapiens took over the worldEnjoy!LINKSFor the original five-hour experience, see: OnHumans.Substack.com/OriginsFor a shorter series on ancient DNA: see OnHumans.Substack.com/DNASupport: Patreon.com/OnHumansThe series was produced together with CARTA (UCSD & Salk Institute). For past recordings of CARTA symposia on human origins, see: Carta.Anthropogeny.org/SymposiaKEYWORDSHuman evolution | Human origins | Science | Biology | Paleoanthropology | Anthropology | Archaeology | Fossils | aDNA | History of life | Life history | Dinosaurs | Primates | Apes | Hominins | Homo sapiens | Evolution of language | Evolution of music | Brain evolution | Paleoneurology | Neanderthals | Denisovans | Neolithic Revolution | Spread of agriculture | Human destiny
Exercise is medicine, however, is there an optimal time to take that medicine? Satchidananda Panda, Ph.D., Salk Institute, discusses the benefits and hazards of exercising, depending on the time of day. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41209]
Exercise is medicine, however, is there an optimal time to take that medicine? Satchidananda Panda, Ph.D., Salk Institute, discusses the benefits and hazards of exercising, depending on the time of day. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41209]
Exercise is medicine, however, is there an optimal time to take that medicine? Satchidananda Panda, Ph.D., Salk Institute, discusses the benefits and hazards of exercising, depending on the time of day. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41209]
Exercise is medicine, however, is there an optimal time to take that medicine? Satchidananda Panda, Ph.D., Salk Institute, discusses the benefits and hazards of exercising, depending on the time of day. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41209]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, describes what the ideal circadian rhythms of a day look like. Dr. Panda explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41210]
How much exposure to daylight is recommended for optimal health? Satchidananda Panda, Ph.D., Salk Institute, answers this question and many more on the therapeutic nature of light. Dr. Panda also discusses indoor lighting considerations in order to simulate day/night cycles. Dr. Panda explains that the use of lighting isn't just for safety and convenience but also for one's health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41208]
How much exposure to daylight is recommended for optimal health? Satchidananda Panda, Ph.D., Salk Institute, answers this question and many more on the therapeutic nature of light. Dr. Panda also discusses indoor lighting considerations in order to simulate day/night cycles. Dr. Panda explains that the use of lighting isn't just for safety and convenience but also for one's health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41208]
How much exposure to daylight is recommended for optimal health? Satchidananda Panda, Ph.D., Salk Institute, answers this question and many more on the therapeutic nature of light. Dr. Panda also discusses indoor lighting considerations in order to simulate day/night cycles. Dr. Panda explains that the use of lighting isn't just for safety and convenience but also for one's health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41208]
How much exposure to daylight is recommended for optimal health? Satchidananda Panda, Ph.D., Salk Institute, answers this question and many more on the therapeutic nature of light. Dr. Panda also discusses indoor lighting considerations in order to simulate day/night cycles. Dr. Panda explains that the use of lighting isn't just for safety and convenience but also for one's health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41208]
How much exposure to daylight is recommended for optimal health? Satchidananda Panda, Ph.D., Salk Institute, answers this question and many more on the therapeutic nature of light. Dr. Panda also discusses indoor lighting considerations in order to simulate day/night cycles. Dr. Panda explains that the use of lighting isn't just for safety and convenience but also for one's health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41208]
We are a movable species. In less than 50 thousand years, Homo sapiens has penetrated practically all corners of humanity. And the story started long before trains and airplanes. This is an episode about thoese epic migrations, with a focus on the two furthest edges of the human migratory map: the Americas in the West and the Polynesian islands in the east. In the end, we discuss emerging evidence that those branches met each other -- work coming directly out of the work of my guest, Andrés Moreno-Estrada.Enjoy!DECODING OUR STORYThis is episode 3 in the "Decoding Our Story" mini-series, recorded live at the Salk Institute's CARTA symposium on ancient DNA. The other episodes are:"The Neanderthal Mirror: Latest Findings About the Lines Between Us" ~ David Gokhman "Beyond Race: A New Outlook on the Shape of Humanity" ~ Diyendo MassilaniFACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: OnHumans.Substack.comSupport: Patreon.com/OnHumansContact Form: https://forms.gle/h5wcmefuwvD6asos8CARTA symposiumThe Moreno labKEYWORDSHuman population history | Human origins | Anthropogeny | Anthropology | Ancient Migration | Out of Africa | Homo sapiens | Ancient DNA | Comparative genetics | Austronesian expansion | Taiwan | Admixture | Archaeogenetics | Archaeology | Polynesia | Easter Islands | Rapa Nui | Hawai'i | Aotearoa New Zealand | Tonga Fiji | Native American origins | Latino genetics | Latinx genetics | Hispanic genetics | Indegenous genetics |
European thinkers once divided humanity into distinct "races". The idea stuck, even if the science moved on. The shape of humanity, it turned out, is far messier than the old race theorists ever imagined.This much is well known.Still , genetics does study different human "populations". Biological differences between these populations are reported every day. So have we simply changed words? Has anything really changed?Yes, everything has changed. To explain why, I'm glad to have Diyendo Massilani on the show.Trained in France and Gabon, Massilani runs a lab at the Yale School of Medicine, where he studies ancient DNA and human adaptations. This fall, his lab has produced one of the most interesting analysis of human biodiversity that I have ever seen. I'm proud to feature it on the podcast before publication. Our conversation begins from the counter-intuitive implications of the Out of Africa theory, and its significance for ideas about race. We then discuss Massilani's own analysis about how the level of genetic differences between modern-day humans.As always, we finish with my guest's reflections on humanity. DECODING OUR STORYThis is episode 2 in the "Decoding Our Story" mini-series, recorded live at the Salk Institute's CARTA symposium on ancient DNA. The other episodes are:"The Neanderthal Mirror: Latest Findings About the Lines Between Us" ~ David Gokhman (published)"Restless Humanity: The Epic Migrations Into America, Polynesia, and... Beyond?" ~ Andrés Moreno-Estrada (4th of Dec)FACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: OnHumans.Substack.comSupport: Patreon.com/OnHumansContact Form: https://forms.gle/h5wcmefuwvD6asos8CARTA symposiumThe Massilani labKEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Paleoanthropology | Genetics | Homo sapiens | Ancient DNA | Comparative genetics | Human biodiversity | Admixture | Archaeogenetics | Archaeology | Mbuti | Papuans | Neanderthals
Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]
Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]
Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]
Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]
Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explains how aligning when we eat, sleep, and move with our body's natural circadian rhythms can profoundly affect metabolic health. Drawing on research from UC San Diego and the Salk Institute, he explores how disruptions in daily patterns—late-night eating, less movement, artificial light—contribute to obesity, diabetes, and fatty liver disease. Wilkinson shows why *when* we eat may be as important as *what* or *how much* we eat, and how time-restricted eating offers a practical, biology-based strategy for preventing cardiometabolic disease and promoting healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41187]
Genetics is rewriting the human story. This week, On Humans takes you behind the scenes of this rapidly evolving frontier via three live-recordings, captured at the Salk Institute's CARTA symposium on ancient DNA. The first episode explores the differences between us and the Neanderthals.For centuries, we tried to understand Neanderthals through stones and bones alone. Now genetics is offering a new tool, allowing researchers to see how ancient bodies and brains developed. In this opening episode, David Gokhman explains what these new tools are revealing about us, Neanderthals, and the lines between us.UP NEXT "Beyond Race: New Surprises About the Shape of Humanity" ~ Monday Dec 1st with Diyendo Massilani"Restless Humanity: The Epic Migrations Into America, Polynesia, and... Beyond?" ~ Thursday Dec 4th with Andrés Moreno-EstradaFACT CHECKINGNo errors have been found as of now. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: OnHumans.Substack.comSupport: Patreon.com/OnHumansContact Form: https://forms.gle/h5wcmefuwvD6asos8CARTA symposiumGokhman's labKEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Archaeogenetics | Archaeology | Paleoanthropology | Genus Homo | Neanderthals | Ancient DNA | Comparative genetics | Archaeogenetics | Language evolution | Origins of language | Symbolic culture | Extinction | Species concept
Brain Talk | Being Patient for Alzheimer's & dementia patients & caregivers
Neuroscience has long focused on neurons, but researchers are turning their attention to another kind of brain cell: glial cells. These non-neuronal cells help shape information processing, support brain circuits and influence vulnerability to neurodegenerative diseases — and there are roughly as many glial cells in the human brain as neurons.Terrence Sejnowski, PhD, is a professor and laboratory head of the Computational Neurobiology Laboratory and Francis Crick Chair at the Salk Institute for Biological Studies. In a recent Salk study, he and his team compared glial cell organization across different brain regions and mammal species, finding striking patterns in how these cells are arranged. His work looks at how glial cells differ across brain regions and species, and what those patterns might mean for brain function and disease risk.In this interview, Sejnowski explains the three main types of glial cells and their roles: astrocytes that help feed neurons and support learning and memory, microglia that act like janitors clearing waste and damage, and oligodendrocytes that insulate nerve fibers so signals travel faster. He discusses how glial cells help clean the brain during sleep, how they may be involved early in conditions like Alzheimer's and multiple sclerosis, and why some research suggests glia could be a better marker of brain health than neurons alone. His insights point to a future in which understanding and protecting glial cells could open new paths for prevention and treatment.—-If you loved watching this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter: https://twitter.com/Being_Patient_Instagram: https://www.instagram.com/beingpatientvoices/Facebook: https://www.facebook.com/beingpatientalzheimersLinkedIn: https://www.linkedin.com/company/being-patientBeing Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://www.beingpatient.com/category/video/
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]
On October 30, 2025, at 9:00 a.m. PT/12:00 p.m. ET, the Salk Institute holds a special live, video edition of our Beyond Lab Walls podcast as we explore why science can't wait. Salk's Vice President of Advancement Michelle Chamberlain will host an in-depth conversation with Chief Science Officer Jan Karlseder and Chief Financial Officer Marie Carter-Dubois about the urgent importance of foundational research—and how it depends on the vital partnership between federal funding and private philanthropy. Discover how current funding challenges are impacting scientific progress and why continued support is essential for breakthroughs that can change the world.
Dr. Diane Hennacy is a Johns Hopkins-trained neuropsychiatrist, author, public speaker, and independent researcher exploring the intersection of science, consciousness, and anomalous phenomena like telepathy and psychic abilities. With over 30 years of clinical experience, she has served on the faculty at Harvard Medical School and participated in think tanks on human consciousness at the Salk Institute. Hennacy's groundbreaking work bridges rigorous scientific inquiry with mysteries of the mind, including studies on autism, savant syndrome, and potential links to extrasensory perception (ESP). Her bestselling book, The ESP Enigma: The Scientific Case for Psychic Phenomena (2009), presents evidence from neuroscience, quantum physics, and case studies to explain psychic experiences. A student of ancient wisdom traditions and an award-winning clinician, she has spoken at international scientific conferences, the United Nations, and venues like TEDx, advocating for open-minded exploration of human potential and consciousness. Hennacy, who also held the title of Miss Oregon Senior America 2017, continues her research through the Hennacy Institute for Consciousness Research, emphasizing integrative medicine and the evolution of human awareness. Shawn Ryan Show Sponsors: https://americanfinancing.net/srs NMLS 182334, nmlsconsumeraccess.org. APR for rates in the 5s start at 6.327% for well qualified borrowers. Call 866-781-8900, for details about credit costs and terms. https://tryarmra.com/srs https://aura.com/srs https://betterhelp.com/srs This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. https://bubsnaturals.com – USE CODE SHAWN https://shawnlikesgold.com https://mypatriotsupply.com/srs https://patriotmobile.com/srs https://ROKA.com – USE CODE SRS https://shopify.com/srs https://trueclassic.com/srs https://USCCA.com/srs Dr. Diane Hennacy Links: Website - https://drdianehennacy.com X - https://x.com/drhennacy41125 Buy The ESP Enigma - https://drdianehennacy.com/purchase-esp-enigma Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dr. Todd Michael is a leading researcher specializing in genome sequencing and analysis, currently serving as a Research Professor at the Salk Institute for Biological Studies and an Adjunct Professor at the University of California, San Diego. His research has made significant contributions to understanding plant genome architecture, particularly through the study of unique and specialized plants that offer insights into adaptive strategies. His innovative work on pangenome tools and long-read sequencing technologies has advanced the understanding of how plant genomes are organized and how they adapt to specific environmental conditions. At CannMed 25, Todd presented “Cannabis Pangenome Exposes Minor Cannabinoid Pathway Potential”, which described how his team integrated 193 cannabis genomes to identify extensive genetic and structural diversity and highlight potential breeding bottlenecks. During our conversation, we discussed: What is a pangenome and why has it replaced single reference genomes Why cannabis is the most interesting plant genome Todd has worked with What has caused cannabis to be one of the world's most diverse plants How transposable elements AKA “jumping genes” contribute to cannabinoid synthase The potential risks of excluding males plants from breeding and more Thanks to This Episode's Sponsor: Advanced Nutrients Founded in 1999, Advanced Nutrients was the first to develop a complete nutrient system that unlocks the true genetic potential of the cannabis plant. Since its inception, the brand has introduced more than 50 innovations to the cultivation community and continues to revolutionize the space through proprietary scientific discoveries. Learn more at AdvancedNutrients.com Additional Resources Michael Lab Website CannMed Video Archive CannMed 25 Photo Gallery
If you've found yourself scrolling through the breastfeeding world online, you know that people have a lot of strong opinions about breast milk. But what exactly do we know about the biology of it? Does breast milk really adapt to a baby's needs? Does it confer immunity? How does making breast milk impact the breastfeeder? Joining Host Flora Lichtman to spin through the science of this sophisticated substance are experts Shelley McGuire and Deepshika Ramanan.Guests: Dr. Shelley McGuire is the director of the Margaret Ritchie School of Family and Consumer Sciences at the University of Idaho.Dr. Deepshika Ramanan is an assistant professor at the Salk Institute for Biological Studies.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
In this episode of the Epigenetics Podcast, we talked with Dr. Joseph Ecker from the Salk Institute about his work on high-resolution genome-wide mapping technologies, specifically how the regulation of gene expression is influenced by DNA methylation, chromatin accessibility, and non-coding RNAs across various cell types and developmental stages. During our conversation, we delve into Dr. Ecker's contributions to the characterization of the genome of Arabidopsis thaliana, a project pivotal in the plant genomics field, where he collaborated on the early sequencing efforts that dramatically outpaced expectations. He highlights the technological advancements that enabled such efficient sequencing and how this foundational work opened new avenues for exploring transcriptional activity. We also discuss Dr. Ecker's pivotal work on the comprehensive DNA methylation map of Arabidopsis, which he developed in collaboration with other researchers. This groundbreaking study established the links between methylation patterns and gene expression, paving the way for further research into how these epigenetic marks influence over gene regulation. He elaborates on the significance of transitioning from traditional methods to more sophisticated techniques, such as RNA-seq, and the lessons learned from sequencing projects that have since been applied to human biology. Dr. Ecker's transition to studying human cells is further explored as he discusses the profiling of DNA methylation in induced pluripotent stem cells (iPSCs), revealing how epigenetic memory can influence cellular differentiation and development. He underscores the importance of understanding these methylation patterns, particularly as they relate to conditions like Alzheimer's disease and stem cell biology, where he examines potential applications of his findings in medical research. As our conversation progresses, we touch upon Dr. Ecker's ongoing projects that utilize advanced multi-omic techniques to investigate the epigenomes of the human brain, focusing on how DNA methylation and gene expression change with age and in the context of neurodegenerative diseases. He details the collaboration efforts with various consortia aimed at cataloging gene regulatory networks and understanding the complex interactions that take place within the brain throughout different life stages. References Mozo T, Dewar K, Dunn P, Ecker JR, Fischer S, Kloska S, Lehrach H, Marra M, Martienssen R, Meier-Ewert S, Altmann T. A complete BAC-based physical map of the Arabidopsis thaliana genome. Nat Genet. 1999 Jul;22(3):271-5. doi: 10.1038/10334. PMID: 10391215. Zhang X, Yazaki J, Sundaresan A, Cokus S, Chan SW, Chen H, Henderson IR, Shinn P, Pellegrini M, Jacobsen SE, Ecker JR. Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell. 2006 Sep 22;126(6):1189-201. doi: 10.1016/j.cell.2006.08.003. Epub 2006 Aug 31. PMID: 16949657. Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, Millar AH, Ecker JR. Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell. 2008 May 2;133(3):523-36. doi: 10.1016/j.cell.2008.03.029. PMID: 18423832; PMCID: PMC2723732. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009 Nov 19;462(7271):315-22. doi: 10.1038/nature08514. Epub 2009 Oct 14. PMID: 19829295; PMCID: PMC2857523. Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):68-73. doi: 10.1038/nature09798. Epub 2011 Feb 2. Erratum in: Nature. 2014 Oct 2;514(7520):126. PMID: 21289626; PMCID: PMC3100360. Related Episodes Epigenetic Reprogramming During Mammalian Development (Wolf Reik) Single Cell Epigenomics in Neuronal Development (Tim Petros) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
This episode is brought to you by Bon Charge and Momentous. We used to think circadian rhythm only applied to sleep. But emerging science has revealed a link between our circadian rhythm and metabolism, cognition, risk for chronic diseases, and many other crucial aspects of our health. Our biology was designed to live in sync with a natural light-dark cycle, but modern-day society has disrupted this natural balance. Today on The Dhru Purohit Show, we're revisiting one of our favorite episodes with Dr. Satchin Panda. Dr. Panda dives deep into his groundbreaking circadian biology research and shares how leveraging your circadian rhythm can dramatically improve your sleep, lower your risk of chronic disease, and improve your cognitive function. They also discuss how time-restricted eating, exercise, and light can be used to help program your circadian rhythm and why it's especially important for shift workers to take advantage of these tools. Dr. Panda is pioneering circadian biology research. He is a professor at the Salk Institute for Biological Studies, a Pew Biomedical Scholar, founder of the UC San Diego Center for Circadian Biology, and recipient of the Julie Martin Mid-Career Award in Aging Research. Dr. Panda has spoken at conferences around the world about his work on circadian rhythms and diabetes, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the professional diabetes societies of Europe and Australia. In this episode, Dhru and Dr. Panda dive into: Why late-night eating is so detrimental to our health (2:15) Organ systems that have a circadian rhythm (8:24) Common ailments that could be related to circadian rhythm disturbances (14:11) Night-shift work and cancer risk (20:19) How poor sleep perpetuates bad food choices (27:00) What happens in the body when you rely on an alarm clock (44:01) Why you need to accumulate sleep debt for better sleep (51:25) Time-restricted eating and sleep (1:00:40) How to combat fragmented sleep (1:15:35) The best time to work out (1:55:50) The link between exercise and cancer (2:07:55) Positive changes for better sleep health on a global scale (2:17:20) Strategies for night-shift workers to combat circadian rhythm disruption 02:45:10) Dr. Panda's research in firefighters (2:48:46) Tips for optimizing your circadian rhythm (3:14:20) Where to follow and support Dr. Panda's work (3:27:50) Also mentioned in this episode: The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight The Circadian Diabetes Code: Discover the Right Time to Eat, Sleep, and Exercise to Prevent and Reverse Prediabetes and Diabetes Download the MyCircadianClock app Try This: 6 Crazy Facts About Sleep Try This: How Exercise Helps Fight Cancer For more on Dr. Satchin Panda, follow him on Twitter @SatchinPanda, Instagram @satchin.panda, or his Website. This episode is brought to you by Bon Charge and Momentous. Right now, BON CHARGE is offering my community 15% off; just go to boncharge.com/DHRU and use coupon code DHRU to save 15%. Optimize your energy and mental clarity with the Momentous Three: Protein, Omega-3s, and Creatine made by and used by the best. Go to livemomentous.com and enter promo code DHRU to get 20% off any order. Learn more about your ad choices. Visit megaphone.fm/adchoices