Podcasts about nadh

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Lucía Prieto habla con ayuda de los mejores especialistas.

In this episode, Prof Chapman explains the critical role mitochondrial health and energy metabolism play in egg competence and embryo development. He breaks down why egg quality declines with age, how chromosome errors happen, and the science behind popular fertility supplements like CoQ10, NADH, and DHEA. Prof Chapman also discusses emerging treatments such as PRP ovarian rejuvenation, why many therapies still lack strong clinical evidence, and what current research may hold for the future of fertility treatment. Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF). Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

Cellular respiration is a combination of two processes: the electron transport chain and oxidative phosphorylation which occur in the inner mitochondrial membrane. Its purpose is to oxidize the high energy molecules NADH and FADH2 produced from catabolism and ultimately drive the synthesis of ATP by ATP synthase. Importantly, most of the oxygen we inhale is consumed by the electron transport chain.

In this episode we discuss: 
-The calories in calories out model of obesity  -Dr Boz's take on fruit and blood glucose spikes -Richard Smith on aging and the NAD+ to NADH ratio   
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps: 0:00 – intro  1:17 – Is fruit evil or is Dr Boz insulin resistant?  5:00 – whether high blood glucose levels drive Alzheimer's and dementia  7:39 – does glucose automatically get converted to fructose and fat?  10:58 – Dr Boz & Glucose Goddess's fearmongering about fruit and glucose spikes   14:12 – Dr Boz parrots Robert Lustig: they're both wrong about fructose  15:43 – concerns with blood sugar spikes when reintroducing carbs and whether using a CGM is worth it  17:32 – less, not more, glucose uptake in the brain creates the conditions for Alzheimer's disease  20:15 – poor glucose utilization as a driver of Alzheimer's and dementia  22:48 – reducing carbohydrate intake causes insulin resistance and less metabolic flexibility  26:27 – possible reasons for Dr Boz's high blood sugar and our advice for Dr Boz  30:31 – our experiences with “keto snacks” and how keto caused intense cravings and binging  33:53 – Richard Smith on keto, NAD+ and aging  35:23 – what Richard Smith misses about glucose and the NAD+ to NADH ratio  41:00 – glucose metabolism leads to a higher NAD+ to NADH ratio than ketone metabolism  44:15 – how low-carb diets can restore the NAD+ to NADH ratio through stress pathways  47:02 – whether ketones are beneficial  49:57 – fats vs carbs: which is the better fuel for the NAD+ to NADH ratio?  55:17 – how to support healthy aging and NAD+ levels (hint: not low-carb)  1:00:31 – what the NAD+/NADH ratio actually indicates  1:05:02 – lower blood sugar with a bioenergetic approach

In this biochemistry-made-simple episode, Dr. Scott Watier and Tommy Welling use the powerful "metabolic battery" analogy to explain why some people feel stuck despite doing everything right with their fasting and food choices. They break down how excess glucose creates a traffic jam in your mitochondria by overloading NADH and depleting NAD+, which promotes insulin resistance and blocks fat burning even when you're following your fasting schedule perfectly. The hosts reveal why reaching for NAD+ supplements misses the point—it's like adding more battery packs to a device you never unplug—and instead provide actionable strategies to restore natural battery cycling through consistent fasting windows, protein-based meals, post-meal movement, and protected sleep. They explain how continuous glucose monitors show you the real-time movie of your metabolic battery's charge-discharge cycle, not just the final score like A1C tests, helping you understand why certain food choices create the wired-and-tired, crashing-after-meals pattern that sabotages your fasting efforts and keeps you trapped in a cycle of cravings and inconsistent results. ⁠⁠⁠⁠⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.youtube.com/watch?v=7gN0hEyCO_E

What makes methylene blue so different from most nootropics is how little it takes to have an effect. In this clip, Mark Sloan explains why ultra-low doses of methylene blue can support mental clarity, calm energy, and mitochondrial performance without overstimulation. You'll hear why: Just a few milligrams can support steady, all-day focus Low doses reduce risk while increasing safety and accessibility Methylene blue supports mitochondrial energy production at the cellular level It plays a role in the NAD to NADH ratio, a key marker of metabolic health The brain benefits disproportionately due to high energy demand Tune in to Episode 68, where we go deeper into methylene blue, mitochondria, metabolic health, and why low-dose strategies often outperform aggressive protocols. Links Watch it on YouTube: https://youtu.be/q5PBJJAypDQ Full episode : https://outliyr.com/68 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick  

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

Was bringt NAD+ wirklich? Unterschiede zu NADH, Sinn und Unsinn von Infusionen, Supplements, Messung, Gender-Gaps & Lifestyle-Hebel.

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

Join our free community, The Women's Peptide Collective, click the Skool link to become a member and to connect, learn, and collaborate. https://www.skool.com/womens-peptide-collective-9663Go to https://thepeptique.com/ to get all your research peptides .As a loyal listener use the discount code POD15 to get 15% off the entire line of products.Have questions? Feel free to reach out to me: tarawest@westwellnessatx.comWant the free peptide guide? Email me tarawest@westwellnessatx.com and comment Guide and I'll shoot it right over!Follow me on instagram AND TikTOk @westwellnessatxMy IM syringes https://a.co/d/4uD5CTiTakeaways: The increasing censorship on social media platforms such as Instagram and TikTok is a significant concern for content creators in the health and wellness sector. I personally experienced shadow banning on Instagram, leading to a reduction in my ability to interact with followers, which highlights the challenges faced by influencers. The newly introduced 'Fat Blaster' product, which is a formulation of lipo C injections, aims to enhance fat metabolism and support energy production. The composition of the Fat Blaster includes L-carnitine, methionine, choline, inositol, B vitamins, and NADH, each contributing uniquely to metabolic processes. Differentiating between MIC shots and lipo C is crucial, as they serve different purposes in fat metabolism and detoxification. How Lipo-C / Fat blaster can work beautifully with your peptidesHow your genetics might impact your outcome ( MTHFR and COMT ) Dosing recommendations for the Fat Blaster should start low and increase gradually, especially for individuals with specific genetic variants affecting metabolism.

Jari Närhi, Co-Founder and CEO of NADMED, a University of Helsinki spin-out revolutionising how we understand and monitor NAD levels. With a background in mechanical engineering and a career spanning medtech, diagnostics and hospital operations, Jari brings a unique systems-level view on cellular health and innovation in clinical testing.In this episode, we explore why NAD (nicotinamide adenine dinucleotide) is so vital for human health, from fuelling ATP production to supporting DNA repair and immune regulation. Jari breaks down the science of NAD+, NADH and glutathione and why traditional lab methods like mass spectrometry have long failed to make NAD testing practical or scalable. We discuss the real-world impact of measuring NAD levels, from chronic illness to long COVID, and how this simple test could become as common as checking haemoglobin in the future.Jari also opens up about NADMED's regulatory journey, the ethical dilemmas of DIY supplementation, the rise of longevity tech, and how AI will transform personalised diagnostics through pattern recognition in metabolic biomarkersTimestamps:[00:00:45] Age vs Disease: What Really Impacts NAD Levels[00:02:28] Why NAD Is Essential for Life[00:03:52] How NAD Decline Signals Deeper Health Issues[00:05:05] From Niacin to NAD: Understanding the B3 Pathway[00:06:00] CE‑Marking and Regulatory Hurdles for Diagnostics[00:06:59] How NADMED Made Testing Faster and More Accessible[00:09:02] The Ethics of Supplementation Without Testing[00:10:16] The VC Path: Funding Deep‑Tech MedTech Innovation[00:14:02] Metabolic Fingerprints and Personalised Medicine[00:17:11] AI, Data and the Future of Longevity DiagnosticsConnect with Jari - https://www.linkedin.com/in/jari-n%C3%A4rhi-38b44/ Learn more about NADMED - https://www.nadmed.com/ Get in touch with Karandeep Badwal - https://www.linkedin.com/in/karandeepbadwal/ Follow Karandeep on YouTube - https://www.youtube.com/@KarandeepBadwal

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

Dove finisce la medicina estetica e dove inizia la longevità?Con il dott. Daniele Trono esploriamo la nuova frontiera tra correttivo e rigenerativo: dal botulino e acido ialuronico ai laser/radiofrequenza, fino a biostimolazione, ozonoterapia endovenosa, NADH/glutatione, stress ossidativo, mitocondri e ormoni bioidentici.Parliamo di pro-aging (non solo anti-aging), personalizzazione, misurazioni oggettive (PCR ultrasensibile, radicali liberi), stile di vita (fotoprotezione, stop fumo, peso stabile), Blue Zones e persino del caso Brian Johnson: quanto serve davvero e cosa copiare con criterio.

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.

Joris Koptod Nioky is filmmaker. Hij werkte meer dan twintig jaar in de culturele sector, onder andere als fotograaf, schrijver en muzikant, voordat hij in 2020 zijn debuut als regisseur maakte. Dat deed hij met ‘Portret van een mislukt schrijver'. Hij won daarmee de Filmprijs van de Stad Utrecht. In 2021 volgde zijn tweede film ‘Dit ben ik niet'. Daarvoor trok hij in bij zijn moeder Rian (71) om haar te laten reflecteren op het moederschap. Joris gebruikt zijn film om Rian te confronteren met de trauma's van het verleden, waar zij zich, na het zien van een tussentijdse montage, totaal niet in herkent. In zijn nieuwe film ‘Zoekjaar' bevraagt Nioky de Nederlandse bureaucratie. Hij volgt Chinese performancekunstenaar Nadh, die na het behalen van zijn diploma op een Nederlandse kunstacademie precies één jaar de tijd krijgt om een baan te vinden - zijn ‘zoekjaar' - anders moet hij weg uit Nederland. Joris Koptod Nioky volgt Nadh en houdt de kijker een spiegel voor: je kunt je naar de regels voegen, maar je kunt ze ook bevragen of verwerpen. Femke van der Laan gaat met Joris Koptod Nioky in gesprek.

Is your inner critic running the show? What if the voice inside your head isn't even yours—but a residue of trauma, stress, or dysfunction? In this eye-opening episode of Healthy Waves, host Avik dives deep into the science behind cellular healing with Claire Martinsen, CEO of Biobloom Injectables. Claire breaks down the truth about NADH and B12—how these molecules work at the mitochondrial level to support energy, mental clarity, emotional regulation, and trauma recovery. We explore how NADH + B12 injections can outperform oral supplements, support therapy and somatic work, and offer real, bioavailable healing—not just hype. Claire shares her personal journey of transformation, including relief from ADHD symptoms, hormonal imbalances, and chronic fatigue—all by supporting her cells instead of suppressing symptoms. This isn't just about wellness trends—it's molecular repair from the ground up. Whether you're a high achiever on the edge of burnout or someone healing from trauma, this episode offers powerful, science-backed insights for real transformation. ABOUT THE GUEST:Claire Martinsen is the CEO of Biobloom Injectables, a science-driven wellness company focused on bioavailable solutions for mental clarity, energy, and healing. With a background in biology and public health, Claire bridges cutting-edge research with practical application, helping people unlock their potential—cell by cell. KEY TAKEAWAYS: NADH (Nicotinamide Adenine Dinucleotide + Hydrogen) is a stable, bioavailable form that supports cellular energy (ATP production), brain health, and DNA repair. Unlike NAD+, which needs conversion and loses potency through digestion, NADH IM injections bypass the gut and deliver 100% absorption. Combined with methylated B12, NADH boosts dopamine, serotonin, and oxygenation in the brain—enhancing focus, mood, and nervous system resilience. Claire shares how NADH helped with her ADHD, back pain, gluten intolerance, immune response, and hormonal balance—without side effects. Bioavailable supplements like NADH+B12 complement trauma therapy and somatic work by stabilizing the nervous system and accelerating healing. Biobloom Injectables is committed to accessible wellness grounded in science, with transdermal patches and sublingual formats underway. Claire's mission is rooted in loss—creating this work in honor of her best friend who died by suicide. Her goal is to make mental wellness and biological repair available to all.   CONNECT WITH THE GUEST:Claire Martinson is available on all social platforms under @wheretoclaire. Her company, BioBloom Injectables, offers services globally, including in India. Visit her page or reach out via social to learn more about her wellness offerings and research-backed products.  WANT TO BE A GUEST ON HEALTHY MIND, HEALTHY LIFE?DM on PodMatchDM Me Here:https://www.podmatch.com/hostdetailpreview/avik CHECK PODCAST SHOWS & BE A GUEST: Tune to all our 19 podcasts: https://www.podbean.com/podcast-network/healthymindbyavik Subscribe To Newsletter: https://healthymindbyavik.substack.com/ Join Community: https://nas.io/healthymind OUR SERVICES Business Podcast Management - https://ourofferings.healthymindbyavik.com/corporatepodcasting/ Individual Podcast Management - https://ourofferings.healthymindbyavik.com/Podcasting/ Share Your Story With World - https://ourofferings.healthymindbyavik.com/shareyourstory STAY TUNED AND FOLLOW US!Medium - https://medium.com/@contentbyavikYouTube - https://www.youtube.com/@healthymindbyavikInstagram - https://www.instagram.com/healthyminds.pod/Facebook - https://www.facebook.com/podcast.healthymindLinkedIn Page - https://www.linkedin.com/company/healthymindbyavikLinkedIn - https://www.linkedin.com/in/avikchakrabortypodcaster/Twitter - https://twitter.com/podhealthclubPinterest - https://www.pinterest.com/Avikpodhealth/ SHARE YOUR REVIEW Share your Google Review - https://www.podpage.com/bizblend/reviews/new/ Share a video Testimonial - https://famewall.healthymindbyavik.com/ #podmatch #healthymind #healthymindbyavik #NADH #biohacking #mentalhealthpodcast #neuroscience #B12 #healingjourney #traumarecovery #mindbodyconnection #wellnessjourney #selfcare #mitochondria #consciousliving #mentalhealthawareness #podcastlife #newpodcast #trending #youtube #wellbeing #mindfulness #healthandwellnesspodcast #HealthyMindHealthyLife

In Episode 27, we wrap up our Metabolism series by diving into one of the most testable—and often misunderstood—topics on the MCAT: The Electron Transport Chain (ETC) and Oxidative Phosphorylation.We cover everything you need to know for MCAT success:

Ready to move beyond glycolysis? In Episode 26 of the Jack Westin MCAT Podcast, Mike and Molly guide you through the Pyruvate Dehydrogenase Complex (PDC) and the Citric Acid (TCA) Cycle—two of the highest‑yield pathways the MCAT loves to test.What we cover- Where it all happens – cytoplasm vs. mitochondrial matrix- PDC outputs & regulation – 2 Acetyl‑CoA, 2 NADH, 2 CO₂ and the key activators/inhibitors that flip the complex on or off- Real‑world connections – how arsenic poisoning and Wernicke‑Korsakoff syndrome derail PDC function- TCA Cycle essentials – step‑by‑step walk‑through, enzyme mnemonics (“Can I Keep Selling Shells…”) and the must‑know Big 3 regulators- High‑yield nuggets – why Succinate Dehydrogenase pulls double duty as ETC Complex II, Ca²⁺ activation during muscle contraction, plus glucogenic vs. ketogenic amino acid entry pointsBy the end, you'll know the exact products (NADH, FADH₂, GTP, CO₂), how to spot test‑maker tricks, and which regulatory enzymes to memorize for test day.

In this week's Jack Westin MCAT Podcast, Mike and Molly pull glycolysis out of the rote-memorization zone and rebuild it as a story you can see, explain—and defend—on test day. Starting with the big-picture difference between aerobic and anaerobic metabolism, they zoom into the 10 classic steps, spotlight why hexokinase and especially PFK-1 are the pathway's “no-turning-back” moments, and finish with the hormonal signals that flip glycolysis on or off in real life. Along the way they debunk lactic-acid myths, link fasting physiology to MCAT passages, and hand you regulation mnemonics that actually stick.Key takeaways at a glance- Net yield, location & oxygen: Cytoplasmic pathway that nets 2 ATP, 2 NADH, 2 pyruvate—no O₂ required.- Energy investment vs. payoff: Why you spend 2 ATP up front and gain 4 later (+2 net).- Regulation checkpoints: Steps 1, 3 & 10 are irreversible; PFK-1 is the commitment step; ATP inhibits, ADP/AMP activate.- Hormonal control: Insulin (via PFK-2) ramps glycolysis up; glucagon turns it down—crucial in fed vs. fasting states.- Clinical & exam links: Cori cycle, muscle soreness myth, and how enzymes like hexokinase signal MCAT question writers.Next episode: PDH complex, electron-transport chain, and oxidative phosphorylation—subscribe so you're ready for the hand-off from glycolysis to ATP powerhouse.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!

The episode opens with an in-depth discussion about the value of open source as a model of development and how the definitional contours of open-source AI differ from those of traditional open-source software. The discussion also explores the characteristics and challenges that distinguish open-source AI models from conventional software development approaches.The discussion goes on to address recent strategic shifts in the AI industry towards more open development, sparked by developments like DeepSeek's open-source R1 model and leaked internal assessments suggesting that open-source communities may be outpacing tech giants.The discussion also explores the complex trade-offs between open and closed AI development. While open-source models offer transparency, democratization, and innovation benefits, they also present cybersecurity vulnerabilities and potential national security risks. Nadh addresses concerns about jailbreaking vulnerabilities in open models, using DeepSeek's recent security lapses as an example, while also examining the limitations and risks of closed proprietary systems.Nadh also provides his perspective on India-specific considerations, including the government's IndiaAI Mission and the decision to develop a homegrown large language model, and discuss the strategic implications of India's approach, which is not expected to be open-source at first, and the potential for India to make meaningful progress in driving open-source AI development as a matter of policy. Episode Contributors Kailash Nadh is the chief technology officer of Zerodha, India's leading stock brokerage platform, where he has led its technology and product stack development since 2013. He is also the co-founder and director of FOSS United, a non-profit foundation based in Bangalore, that aims to provide grassroot support to free and open-source software projects and communities in India. In addition to being a full-stack software developer with more than two decades of technical experience, Nath holds a PhD in artificial intelligence and computational linguistics. His most recent writings also provide a compelling analysis of open-source software developments and AI breakthroughs, including in the Indian context. Shruti Mittal is a research analyst at Carnegie India. Her current research interests include artificial intelligence, semiconductors, compute, and data governance. She is also interested in studying the potential socio-economic value that open development and diffusion of technologies can create in the Global South. Every two weeks, Interpreting India brings you diverse voices from India and around the world to explore the critical questions shaping the nation's future. We delve into how technology, the economy, and foreign policy intertwine to influence India's relationship with the global stage.As a Carnegie India production, hosted by Carnegie scholars, Interpreting India, a Carnegie India production, provides insightful perspectives and cutting-edge by tackling the defining questions that chart India's course through the next decade.Stay tuned for thought-provoking discussions, expert insights, and a deeper understanding of India's place in the world.Don't forget to subscribe, share, and leave a review to join the conversation and be part of Interpreting India's journey.

Dr. Amanda Williams discusses the anti aging effects of Creatine and NADH.Jerry Hickey discusses the power of Grape Seed and Bio-curcumin.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMEn este episodio Patri Psicóloga nos explica que pensar mucho no siempre equivale a pensar mejor, que la ansiedad tiene muchas caras y que ocuparnos de todo se paga con la salud física y mental. Si te gusta el episodio y quieres vernos en directo en el teatro, compra tus entradas en www.patripsicologa.com/teatroEn abril el mecenas es el complemento alimenticio NADH de HSN. Seguro que has oído hablar del NAD. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan un 65% entre los 30 y 70 años. Y eso se nota: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como dar un empujón a tu energía celular. Puede ayudar a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud. Llévate de regalo* una botella HSN de acero inoxidable en pedidos superiores a 79 euros. Usa el cupón CRISMITRE. *Regalo disponible hasta fin de existencias. No acumulableInstagram @thebeautymailTwitter @cristinamitreYouTube https://www.youtube.com/c/CristinaMitreLinkedIn Cristina Mitre ArandaFacebook https://www.facebook.com/CrismitreTrack: "Walk!", lov3rMusic provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/d64537c5-4d7f-4ac4-87b0-4bc2fd228abd?utm_source=attributionListen on Spotify: https://go-stream.link/sp-lov3rTrack: "Latin Party.-Instrwav"Music provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/cb324323-0998-4319-a5c0-8c9380be5c33 Hosted on Acast. See acast.com/privacy for more information.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMComer sano no es hacer dietas extremas, ni pasar hambre, ni vivir sin pan toda la vida. Es aprender a elegir, organizarse y disfrutar de todos los grupos de alimentos sin miedo. ¿Y lo mejor? No tiene por qué ser caro. Nos lo va a contar Jessica Hierro en este episodio.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COM¿Es posible tener un problema con el alcohol sin darse cuenta? El alcohol forma parte de nuestra vida: nos reunimos en torno a él, lo asociamos con relax, descanso o fiesta. Pero esa normalización puede esconder una realidad compleja: la adicción al alcohol. Y no siempre tiene la forma que imaginamos. Bajo una apariencia “normal”, muchas personas sufren dependencia del alcohol. El Dr. Gabriel Rubio, jefe de Psiquiatría del hospital 12 de Octubre, especializado en tratamiento del alcoholismo, nos va a mostrar cómo se inicia la adicción al alcohol, cómo cambia con los años, qué impacto tiene en la persona y su familia, qué supone recuperarse o qué papel juegan la vergüenza y la culpaEn abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

Hey, welcome back! Today, we're diving into something that can seriously up your game when it comes to energy, performance, and even longevity—NAD+. If you haven't heard of it, don't worry, we've got you covered. We're also going to talk about some awesome peptide stacks that can keep you feeling energized and performing at your best—whether that's crushing it in your workouts or staying sharp through your workday grind. So, if you're looking to boost your fitness, stay more focused at work, or just feel more energized in general, this episode's for you. What is NAD+? Alright, let's kick things off with the basics—what is NAD+? It stands for Nicotinamide Adenine Dinucleotide, which is a bit of a mouthful, but it's actually a co-enzyme that's super important for energy production in your body. Think of it as the fuel for your cells. Without NAD+, your cells can't make energy, which is obviously a big deal. Now, here's the thing—our NAD+ levels drop as we get older. This can lead to feeling tired, slower recovery, and just a general lack of energy. But don't panic—there's good news! Supplementing with NAD+ (either through injections or IV infusions) or even helping your body boost its NAD+ production naturally can actually reverse some of these aging effects. Not only will you feel more energized, but you'll also get benefits like improved focus, better endurance, faster recovery, and even some anti-aging perks. How Does NAD+ Work? So, how does NAD+ actually work in the body? It plays a huge role in energy production by helping with mitochondrial respiration. Basically, it cycles between two forms—NAD+ and NADH—to help produce ATP, which is the energy currency of your cells. But that's not all. NAD+ also impacts proteins called sirtuins that regulate metabolism, stress responses, and longevity. It even activates enzymes like PARPs that help with DNA repair, which is key for maintaining cell integrity, especially when dealing with things like aging and stress. And on top of that, NAD+ is involved in cell signaling pathways that influence things like inflammation, insulin sensitivity (which could help with weight management), and even your circadian rhythm. What Are the Benefits of NAD+? So, you've got energy, anti-aging, and DNA repair—but that's just the start. NAD+ can also help with memory, focus, and mental clarity by keeping your neurons healthy and protected from neurodegeneration. In fact, there's some research showing that NAD+ therapy could even help with managing withdrawal symptoms and cravings, particularly for alcohol and opioid dependencies. Are There Any Side Effects of NAD+? Like anything, NAD+ therapy can have some side effects, though it's generally considered safe. Some people may experience things like low blood pressure, flushing, nausea, headaches, or fatigue, especially after an injection. But the good news is these side effects tend to go away on their own, and over time, your energy levels will start to improve. Let's Talk About Stacking NAD+ for Even More Benefits Okay, so you're probably wondering how to make the most of NAD+. Well, stacking it with the right supplements can seriously amplify its effects. But it's not just about throwing a bunch of stuff together and hoping for the best. You've got to have the right combos to really level up your energy, endurance, and focus. Here are my top four NAD+ stacks: NAD+ + Glutathione This stack is great for detoxing and reducing oxidative stress. It supports your cellular health and helps fight free radicals, which is key for feeling good and staying healthy long-term. NAD+ + 5 Amino-1MQ If you're looking to support metabolic health and fat loss, this one's for you. 5 Amino-1MQ is a peptide that works really well with NAD+ to boost fat-burning and improve metabolic efficiency. NAD+ + Thymosin Alpha-1 Thymosin Alpha-1 is a peptide that's all about boosting your immune system. When combined with NAD+, it enhances your immune-regulating effects, making it a powerful duo for longevity and immune resilience. NAD+ + Epitalon Epitalon is a peptide that helps with telomere health, which is essential for anti-aging. When paired with NAD+, it supports cellular repair and overall longevity. If you're thinking about adding NAD+ to your routine, I'd recommend starting with a high-quality supplement. Take it consistently, pair it with the right stacks, and give it a bit of time to work its magic. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey.  Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

What are the pros, cons, and efficacy of dihydronicotinamide riboside (reduced NR), perhaps the most potent NAD+ precursor, as well as reduced NMN, taking NAD+ directly, or making it from scratch from tryptophan?

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMHoy vamos a hablar de amor propio con todo un experto: Walter Riso. Si miras su web verás que trabaja desde hace treinta años como psicólogo clínico y formador de terapeutas, práctica que alterna con el ejercicio de la cátedra universitaria en Latinoamérica y España, y la publicación de textos científicos y de divulgación, en diversos medios. Ha publicado 30 libros, entre textos técnicos y de divulgación, que han sido traducidas a más de 20 idiomas. Hoy vamos a profundizar con él en los temas de su último libro, Los siete pilares del amor propio, cuya lectura es más que recomendable para mejorar la relación que tienes con la persona más importante de tu vida: TÚ.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

Story at-a-glance High blood sugar in Type 2 diabetes overwhelms cellular machinery like a chaotic factory, creating not just oxidative stress as previously thought, but also a more fundamental problem called reductive stress. Reductive stress occurs when there's an oversupply of electron-carrying molecules in cells, creating a "traffic jam" of electrons that can't be processed efficiently by the mitochondria's electron transport chain While traditional views focused on oxidative stress alone, scientists now understand that reductive stress actually triggers oxidative stress. It's the initial spark that sets off a chain reaction of cellular damage in diabetic conditions When the main pathway for processing glucose becomes blocked due to reductive stress, sugar molecules get diverted into harmful alternative pathways, creating additional toxic byproducts and inflammation The combination of reductive and oxidative stress explains many serious complications of diabetes including neuropathy, retinopathy, nephropathy, and cardiovascular problems — all stemming from this initial electron overload Understanding reductive stress offers new therapeutic possibilities. Instead of just focusing on lowering blood sugar or fighting oxidative damage after it occurs, effective treatments target the electron transport chain efficiency and/or help cells recycle NADH more effectively

Guest Kailash Nadh Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard Littauer sits down with Kailash Nath, CTO of Zerodha, to delve into the dynamics of funding and sustaining open-source projects. They explore the establishment of Zerodha's FLOSS/Fund, which allocates a million dollars annually to support pivotal open source projects and discuss the development of the funding.json format to streamline grant applications. The conversation also covers the challenges of creating such funds, including regulatory hurdles, and aims to make financial assistance globally accessible. From detailing efforts to revive India's open-source communities through the FOSS United Foundation to highlighting the obstacles and innovative models in funding open-source software, the episode provides a comprehensive look at both global and Indian perspectives. Hit download now! [00:01:14] Richard brings up the FLOSS/Fund, a $1 million annual commitment to open source projects. Kailash confirms that the fund is still active and explains how it recently became more structured and a small team has been formed to manage the logistics of the fund. [00:02:48] The FLOSS/Fund has been created to publicly commit to supporting open source in a structured way. Kailash points out that while other companies give donations to open source, there are few structured initiatives from large organizations. [00:04:33] Kailash expresses frustration that few billion-dollar companies have set up similar initiatives to support open source projects. [00:06:24] Kailash explains that the FLOSS/Fund is open to the global open source community and target systemically important projects like libraries and widely used software tools. [00:08:14] Richard inquires about the application process and Kailash explains instead of traditional grant forms, projects must create and publish a “funding.json” file. [00:10:35] Kailash shares that the structured application method is designed to avoid the usual awkwardness of fundraising conversations and streamline the process. [00:13:31] The two discuss the difficulty maintainers face when articulating the importance of their projects, particularly for maintainers who may not have strong written communication skills, Kailash emphasizes that the funding.json method does not replace narrative descriptions but simplifies signaling. [00:16:17] The conversation switches to global scope and prioritization as Kailash tells us Zerodha's open source contributions are not limited to projects they directly use, the fund is open to all global projects, and Zerodha hopes to support projects that are crucial for open source infrastructure. [00:17:09] Kailash discusses the complexity of sending money internationally from India. [00:18:59] We learn the goal is not to make funding.json go viral through financial incentives, but to organically grow adoption if the tool proves valuable. [00:20:49] Richard and Kailash explore the broader challenges of sustaining open source projects beyond funding, such as building healthy communities and incentivizing the proper use and citation of open source infrastructure. [00:25:32] Kailash discusses the Indian open source ecosystem. [00:30:29] Kailash explains how Zerodha's initiatives aim to push the Indian industry to give back more to the open source community. He hopes that their efforts will inspire other companies to set up similar initiatives. [00:32:12] Find out where you can donate to Floss fund and follow Kailash online. Spotlight [00:32:56] Richard's spotlight is his first grade teacher, Mrs. Barril. [00:33:25] Kailash's spotlight is Jim Martsolf who introduced him to “webmastering.” Links SustainOSS (https://sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) richard@sustainoss.org (mailto:richard@sustainoss.org) SustainOSS Discourse (https://discourse.sustainoss.org/) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Kailash Nadh LinkedIn (https://www.linkedin.com/in/kailashnadh/) Kailash Nadh Website (https://nadh.in/) Zerodha (https://zerodha.com/) funding.json (https://floss.fund/funding-manifest/) Sustain Podcast-Episode 153: Kailash Nadh and the FOSS United Foundation (https://podcast.sustainoss.org/153) FLOSS/Fund (https://floss.fund/) FFmpeg (https://ffmpeg.org/) Zig (https://ziglang.org/) Sustain Podcast-Episode 247: Chad Whitacre on the Open Source Pledge (https://podcast.sustainoss.org/247) Open Source Pledge (https://opensourcepledge.com/) Announcing FLOSS/fund: $1M per year for free and open source projects-post by Kailash Nadh (https://floss.fund/blog/announcing-floss-fund/) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Kailash Nadh.

Geburtstagsspecial: Insights zu Romans liebsten Produkten für mehr Energie und Wohlbefinden   Heute habe ich einen ganz besonderen Gast: meinen Mann Roman Gruber. Gemeinsam sprechen wir über sein exklusives Geburtstagsbundle, das einige seiner Lieblingsprodukte enthält. Im Fokus stehen der Faceformer, das Energy, das Colostrum Strong Flüssig und das Magnesiumtaurat. Roman erläutert, warum gerade diese Produkte zu seinen Favoriten gehören und welche Vorteile sie bieten. Zudem geben wir spannende Einblicke in die Anwendung und Wirkung dieser Produkte. Romans Lieblingsproduktebundle FACEFORMER - Ein innovatives Trainingsgerät, das die Nasenatmung und die Muskelentwicklung im Gesichtsbereich verbessert. Besonders hilfreich bei Schnarchen und Stressabbau ENERGY - Ideal für Menschen, die einen Energieboost benötigen oder an Migräne leiden. Enthält Q10 und NADH für die Unterstützung der Mitochondrien FLÜSSIGES COLOSTRUM - Ein unverzichtbares Notfallprodukt zur Stärkung des Immunsystems. Perfekt für akute Situationen wie Halsschmerzen oder Hautprobleme MAGNESIUMTAURAT - Eine besonders gut aufnehmbare Form von Magnesium, die auch nicht zu Durchfall führt, wie das bei anderen Magnesiumpräparaten der Fall sein kann LINKS Romans Lieblingsproduktebundle: https://shop.arktisbiopharma.ch/romans-lieblingsprodukte-bundle/B-014 Magnesiumtaurat: https://shop.arktisbiopharma.ch/mgt-magnesiumtaurat-kapseln/110380-6er Colostrum Strong: https://shop.arktisbiopharma.ch/colostrum-strong-125-ml/360000 Faceformer: https://shop.arktisbiopharma.ch/faceformer-zero/DI-FF-GPR-V Energy: https://shop.arktisbiopharma.ch/energy-q10-nadh-60-kps/100309-6er Energy im Fokus: Roman Gruber im Interview über das neue Produkt mit Q10 und NADH (DG229) - https://arktisbiopharma.ch/energy-im-fokus-roman-gruber-im-interview-ueber-das-neue-produkt-mit-q10-und-nadh-dg229/ Uwe Gröber über Magnesium und Magnesium-Taurat – Wichtige Erkenntnisse eines Mikronährstoffexperten (DG269) - https://arktisbiopharma.ch/uwe-groeber-ueber-magnesium-und-magnesium-taurat-wichtige-erkenntnisse-eines-mikronaehrstoffexperten-dg269/ Die Folgenotizen und eine schriftliche Zusammenfassung zu dieser Episode findest du unter: https://www.arktisbiopharma.ch/279   Als Podcasthörer:in bekommst du von uns einen Rabatt auf unsere Produkte. Und zwar 15% Rabatt auf deinen ersten Einkauf (1-mal anwendbar, nur auf nicht bereits rabattierte Produkte). Der Gutscheincode ist in beiden Arktis BioPharma Shops in der SCHWEIZ und in DEUTSCHLAND gültig.  Gib hierfür den Gutscheincode podcast15 ein, bevor du deine Bestellung abschliesst. https://shop.arktisbiopharma.ch https://arktisbiopharma.de/ Abonniere den Darmglück-Podcast in deiner Lieblings-Podcastapp (Apple Podcasts, Spotify, Deezer, Google Podcasts etc.), indem du “Darmglück” in die Suche eingibst.

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Website: https://t.me/dannyroddy   Danny's Substack: https://dannyroddy.substack.com/   Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson's Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson's Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson's Blueprint and how to measure health 32:39 – Bryan Johnson's supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall's response to our take on glucagon and insulin 1:24:17 – glucagon's short-term and long-term effects on metabolic function 1:26:46 – glucagon's role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health

In this episode, we delve into a revolutionary longevity molecule that you might not have heard of before: 1-MNA. If you're interested in staying younger longer and if you want to maintain your energy and vitality then this is an episode for you. Perhaps you have read the groundbreaking book by Dr David Sinclair "Lifespan" where he talks about NAD and how crucial it is for the body and how it can help upregulate sirtuin genes (longevity genes) and help you maintain your cellular health and energy. We are now 4 years on we have more data, studies and information to share in this arena. Perhaps you have been trying to improve  your NAD metabolism, taking NMN (nicotinamide mononucleotide)  or NR (nicotinamide riboside), and upregulating sirtuin genes, if you have then you need to hear this.  We'll explore the intricacies of NAD pathways, the role of key enzymes, and why simply supplementing with NAD precursors may not be the best holistic approach and how we can improve on that approach to anti-aging Key Points Discussed: Introduction to NAD Metabolism: Overview of previous episodes on NAD metabolism with experts like Professor Joseph Baur, Dr. Elizabeth Yurth from the Boulder Longevity Institute, and Dr. Elena Seranova. Importance of understanding the complexities of NAD pathways beyond the basics. Understanding 1-MNA: Explanation of 1-MNA and its role in controlling NAD levels by blocking the enzyme NNMT (Nicotinamide N-methyltransferase). The dangers of upregulating NNMT, which degrades NAD and can lead to various health issues. Key Enzymes in NAD Metabolism: Discussion on the salvage pathway and two critical enzymes that degrade NAD. Importance of regulating NNMT to prevent its deleterious effects, particularly in senescent cells, cancer cells, and fat cells. Benefits of 1-MNA How 1-MNA can help maintain a balanced NAD metabolism by inhibiting NNMT. Potential benefits for conditions like schizophrenia, neurodegeneration, liver diseases, and cancer. Research and Studies: Overview of studies showing the positive effects of 1-MNA on post-COVID conditions, inflammation, and mitochondrial function. Insights from animal studies on 1-MNA's protective effects against metabolic disorders. Practical Applications: Recommendations for integrating 1-MNA into supplement regimens, especially for those taking NMN or NR. Potential benefits for various conditions, including obesity, metabolic syndrome, cardiac disease, liver disease, cancer risk, long COVID, and fatigue. Balancing NAD Levels: Importance of maintaining NAD levels for energy production, DNA repair, neurotransmitter health, and longevity. The role of NAD as a redox molecule and the balance between NAD+ and NADH. Conclusion: Encouragement to explore further research on NNMT and its impact on health. Final thoughts on the potential of 1-MNAas a crucial supplement for maintaining NAD balance and promoting longevity. References and Links: Boulder Longevity Institute: https://boulderlongevity.com/ SSRP Institute: https://ssrpinstitute.org/ Studies on NNMT and related conditions: Research   If you enjoyed this episode, please give it a like, share, and subscribe to the YouTube channel. Tune in weekly for more interviews with top doctors and scientists on health optimization and longevity. Get Your 1-MNA now If you want to start supplementing with 1-MNA to support your own healthy aging journey, to upregulate your NAD metabolism, support sirtuin genes and prevent the overexpression of the deleterious NNMT Enzyme you can buy it here: 1-MNA and use code NAD to get $25 off your first order Stay up-to-date with the latest research and evolve with the science to optimize your health and longevity. See you in the next episode!       Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

In this episode of The Metabolic Classroom, Dr. Bikman introduces the concept of the Randle Cycle, also known as the glucose fatty acid cycle, in a lecture aimed at providing a better understanding of metabolism. The Randle Cycle, first identified by Dr. Philip Randle and his colleagues in the 1960s, explores how cells decide between using glucose or fatty acids for fuel. Dr. Bikman emphasized that this cycle has been misinterpreted on social media and aims to clarify its relevance in metabolic functions and nutritional decisions.https://www.insuliniq.com 00:00 - Introduction to the Metabolic Classroom and Dr. Ben Bikman01:00 - Overview of the Randle Cycle (Glucose Fatty Acid Cycle)02:00 - Historical Background: Philip Randle's Research03:00 - Experimental Model: Perfused Rat Hearts04:00 - Key Terms: Glucose and Fatty Acids05:00 - Concept of Substrate Competition06:00 - Reciprocal Inhibition: Fats vs. Glucose08:00 - Fatty Acid Oxidation Process10:00 - Biochemical Pathways: Acetyl-CoA, NADH, and Pyruvate Dehydrogenase12:00 - Role of Citrate in Glycolysis Inhibition14:00 - Glucose Utilization and Malonyl-CoA16:00 - Insulin's Role in Fuel Selection18:00 - Insulin's Impact on Glucose and Fat Burning20:00 - Diabetes Case Study: Type 1 and Type 222:00 - Type 1 Diabetes: High Glucose and Fatty Acids24:00 - Ketones Production in the Liver26:00 - Type 2 Diabetes: Insulin Resistance and Metabolic Inflexibility28:00 - Insulin Resistance in Fat Cells30:00 - Metabolic Inflexibility in Type 2 Diabetes32:00 - Insulin Resistance in the Brain34:00 - The Impact on Hunger and Neurological Disorders36:00 - Conclusion: Importance of Insulin in Metabolic Health#Metabolism #RandleCycle #DrBenBikman #InsulinResistance #GlucoseMetabolism #FattyAcidOxidation #MetabolicHealth #DiabetesResearch #Ketosis #Type1Diabetes #Type2Diabetes #InsulinRole #CellBiology #NutritionalScience #MetabolicFlexibility #Ketones #GlucoseUtilization #FatBurning #BiomedicalScience #HealthLectureMy favorite meal-replacement shake: https://gethlth.com (discount: BEN10)My favorite electrolytes (and more): https://redmond.life (discount: BEN15)My favorite allulose source: https://rxsugar.com (discount: BEN20)References:https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/randle-cycle Insulin Regulation of Ketone Body Metabolism: https://onlinelibrary.wiley.com/doi/10.1002/0470862092.d0308The Effects of a Ketogenic Diet and Exercise Interventions on Cognitive Function: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.31.1_supplement.lb810(Due to character length constraints, not every reference is posted above. For a complete list, please email: support@insuliniq.com with your request.) Hosted on Acast. See acast.com/privacy for more information.

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Debjyoti Kundu at Indiana Biosciences Research Institute's as he shares his poster titled "Pivotal role of NADH:ubiquinone oxidoreductase assembly factor 8 in beta cell stress adaptation".

Tá bácús Harrington sa Neidín ag eirí as an ngnó. Deireadh ré don mbácús neamhspleach a bhí soláthar aráin sa chontae ó 1995

Episode 31: Biochem of Sports Nutrition | Cauliflower Taco Meat Welcome to the Diet NPO Podcast! Your pod for RD Exam and nutrition questions. Come listen this week as we discuss Biochemistry of Sports Nutrition combined with practice questions and some Cauliflower Taco Meat! 1. If an athlete is training and develops a higher VO2 max, they would be relying more on which of the following processes? A. Anaerobic Glycolysis B. Lactic Acid Cycle  C. Creatine-Phosphate Pathway  D. Aerobic Glycolysis 2. Under anaerobic conditions, pyruvate can be converted into ______ through the Cori Cycle and can then be converted to ______ through gluconeogenesis. :  A. Lactate, Acetyl CoA B. Acetyl CoA, Glucose C. Lactate, Glucose D. Acetyl CoA, NADH 3. The pathway of aerobic metabolism that is producing the most amount of ATP through NADH and FADH intermediates, is known as the ________. A. Kreb's Cycle B. Citric Acid Cycle C. Aerobic Glycolysis D. Electron Transport Chain DM for your RD Exam tutoring needs! Instagram: @zak_snacks Threads: @zak_snacks Youtube: Zak Kaesberg MS, RDN

https://passionstruck.com/passion-struck-book/—Order a copy of my new book, "Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life," today! The book was picked by the Next Big Idea Club as a must-read for 2024, the winner of the Business Business Minds Best Book 2024, and shortlisted for the Eric Hoffer First Grand Prize.In this episode of Passion Struck, host John R. Miles interviews Oz Garcia, a trailblazer in nutritional science and healthy aging. Oz shares insights on the impact of nutrition on health, the importance of lifestyle choices, and the role of intermittent fasting in optimizing health and longevity. Oz emphasizes the significance of probiotics, prebiotics, and postbiotics for gut health and the benefits of supplements like NADH for energy and acetyl L-carnitine for brain function.Full show notes and resources can be found here:  https://passionstruck.com/dr-oz-garcia-on-the-secrets-to-a-healthier-life/In this episode, you will learn: The Power of Intermittent Fasting: Insights from Oz GarciaUnraveling the Secrets to a Healthier Life with Oz GarciaUnderstanding the Importance of Sleep with Oz GarciaProbiotics, Prebiotics, and Postbiotics: Oz Garcia's Guide to Gut HealthNADH and Acetyl Carnitine: Oz Garcia's Energy-Boosting SupplementsBrain Health Essentials: Acetyl L-Carnitine and Alpha-GPC with Oz GarciaMagnesium for Better Sleep and Nutrient Absorption: Oz Garcia's RecommendationsAll things Oz Garcia: https://ozgarcia.com/SponsorsBrought to you by Indeed. Head to https://www.indeed.com/passionstruck, where you can receive a $75 credit to attract, interview, and hire in one place.Brought to you by Nom Nom: Go Right Now for 50% off your no-risk two week trial at https://trynom.com/passionstruck.Brought to you by Cozy Earth. Cozy Earth provided an exclusive offer for my listeners. 35% off site-wide when you use the code “PASSIONSTRUCK” at https://cozyearth.com/This episode is brought to you by BetterHelp. Give online therapy a try at https://www.betterhelp.com/PASSIONSTRUCK, and get on your way to being your best self.This episode is brought to you By Constant Contact:  Helping the Small Stand Tall. Just go to Constant Contact dot com right now. So get going, and start GROWING your business today with a free trial at Constant Contact dot com.--► For information about advertisers and promo codes, go to:https://passionstruck.com/deals/Catch More of Passion StruckWatch my interview with Dr. Anthony Youn On How To Feel Great And Look Your BestCan't miss my solo episode on The Reverse Aging Effect: How To Stay Young And HealthyListen to my episode with Dr. Kara Fitzgerald On How To Become A Younger You By Reversing Your Biological AgeMy solo episode on The Science Of Healthy HabitsCan't miss my episode with Dr. Mark Hyman On How Personalized Medicine Is Revolutionizing HealthcareLike this show? Please leave us a review here-- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally!How to Connect with JohnConnect with John on Twitter at @John_RMiles and on Instagram at @john_R_Miles.Subscribe to our main YouTube Channel Here: https://www.youtube.com/c/JohnRMilesSubscribe to our YouTube Clips Channel: https://www.youtube.com/@passionstruckclips

Ceoltóirí ó bhunscoil agus ó Mheánscoil San Nioclás a fágaint slán le máistreás poist na Rinne inniu. Labhair Sláine Ní Chathalláin le Fionn Mac Giolla Choda agus Breege Ui Mhurchú agus fearg orthu go raibh deireadh ré ag Oifig Poist na Rinne.

Jimmy Breathnach, Máire Breathnach, Nioclás Ó Gríoftáin, Deaglán Turaoín a léiriú a mí shástacht le dúnadh Oifig Poist na Rinne.

In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the potential therapeutic implications of SS-31 peptide not only on the cellular level in mitigating mitochondrial dysfunction, but also its role in various disease settings and exercise capacity as well. Topics: 1. Overview of Mitochondrial Structure - Outer membrane and inner membrane with cristae - Mitochondrial matrix containing DNA, ribosomes, and enzymes - Inner membrane with electron transport chain complexes (I to IV) and ATP synthase 2. Functions of Electron Transport Chain Complexes - Complex I (NADH Dehydrogenase) transferring electrons from NADH to ubiquinone - Complex II (Succinate Dehydrogenase) transferring electrons from FADH2 to coenzyme Q - Complex III (Cytochrome bc1 Complex) passing electrons to cytochrome c and pumping protons - Complex IV (Cytochrome c Oxidase) transferring electrons to oxygen to form water and pumping protons 3. Role of Electron Transfer in ATP Synthesis - Proton pumping by complexes I, III, and IV creating an electrochemical gradient - ATP synthase utilizing proton gradient to synthesize ATP from ADP and Pi 4. Generation and Effects of Reactive Oxygen Species (ROS) - Formation of ROS as byproducts of ATP production - Types of ROS and their damaging effects on cellular components 5. Causes of ROS Production and Mitochondrial Dysfunction - Electron leak leading to premature electron reactions with oxygen - Factors contributing to increased ROS production such as environmental toxins and diet --- Leela Quantum Tech --- 6. Importance of Lipid Composition in Mitochondrial Membrane - Phospholipids, particularly cardiolipin, in the inner mitochondrial membrane - Role of cardiolipin in maintaining membrane integrity and supporting respiration proteins 7. Impact of ROS and Lipid Peroxidation on Mitochondrial Function - ROS-induced lipid peroxidation affecting cardiolipin composition - Implications of cardiolipin peroxidation in diseases like metabolic dysfunction and insulin resistance 8. SS-31 Peptide Intro - Accumulation in the inner mitochondrial membrane - Dimethyltyrosine residue scavenging oxyradicals and inhibiting lipid peroxidation 9. Mechanisms of Action of SS-31 Peptide - Stabilization of lipid constructs in the inner mitochondrial membrane - Prevention of mitochondrial permeability transition pore (mPTP) opening - Reduction of mitochondrial ROS and prevention of mitochondrial swelling and cell death 10. Applications and Research Areas of SS-31 Peptide - Studies in neuroinflammation, neurodegeneration, diabetes, age-related diseases, kidney disease, and cardiac function - Potential as a therapeutic agent for diseases associated with mitochondrial dysfunction 11. Conclusion - Overview of SS-31 peptide's mechanisms and potential applications - Reminder to always consult licensed medical professionals. Thanks for tuning in! Leela Quantum Tech Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! ⁠⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠⁠ Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok ⁠⁠⁠⁠⁠@chloe_c_porter⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism.  This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may  Access the show notes, transcript, and comments here.  

Today's episode discusses the ongoing conflict between Israel and Hamas, with insights into the spiritual dimensions and the generational divide of perspectives on this issue. We're exploring why PM Netanyahu has said he rejects a truce with Hamas, whether reform is possible, and the biblical analysis behind this. Take advantage of this prophetic perspective on this complex issue! Today's Sponsor Strong Cell is designed to replenish and give back to your cells. It's a daily liquid supplement formulated with three key nutrients your cells need to function properly - NADH, CoQ10 and Collagen. Everyday stressors deplete your cells of these three things, causing them to function less effectively. With their proprietary process, Strong Cell can help replenish and revitalize your health at the cellular level. BEGIN YOUR JOURNEY TO CELLULAR HEALTH TODAY by going to lancewallnau.com/strongcell

Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological.  Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com  Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals.  Mr. Cash has an MS in physics from the University of Oklahoma.  As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business,  Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm.   In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer. 

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Josh Rabinowitz is a Professor of Chemistry and Integrative Genomics at Princeton University, where his research focuses on developing a quantitative, comprehensive understanding of cellular metabolism through the study of metabolites and their fluxes. In this episode, Josh focuses the discussion on three main topics: metabolomics, NAD (and its precursors), and cancer metabolism. The metabolomics discussion starts with a broad definition of metabolism, metabolites, and fluxomics before diving deep into glucose metabolism, lactate as a fuel, movement of lactate, and the regulation of these substrates. He then gives a detailed explanation of the electron transport chain and Krebs cycle and their implications with respect to both drugs and nutrition while also explaining how NAD is central to the process of energy generation. He then discusses the age-related decline in NAD and what current literature says about efforts to increase NAD through intravenous or oral supplementation with the precursors NMN and NR, including whether doing so provides any advantage to lifespan or healthspan. Finally, Josh ends the conversation talking about cancer metabolism and how one particular intersection between cancer metabolism and immunotherapy might provide a hopeful outlook on the future of cancer treatment. We discuss: Josh's background and unique path to becoming a research scientist at Princeton [3:30]; What sparked Josh's early interest in metabolism [11:15]; Metabolomics 101: defining metabolites and how they are regulated [16:30]; Fluxomics: metabolism as a system in action [26:00]; The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation [33:30]; The important role of lactate as an alternate fuel [36:30]; Fasting lactate levels as a potential early indicator of metabolic dysfunction [48:00]; The beauty of the Krebs cycle and the role of NAD in energy production [53:15]; How the drug metformin acts on complex I of the electron transport chain [1:05:00]; The difference between NADH and NADPH [1:08:45]; NAD levels with age, and the efficacy of supplementing with intravenous NAD [1:10:45]; The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN [1:22:15]; Exploring the hypothesis that boosting NAD levels is beneficial [1:32:30]; Cancer metabolism and the intersection with immunotherapy [1:39:00]; Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more [1:46:15]; The challenge of treating pancreatic cancer [1:50:30]; Epithelial cancers that might respond to metabolic approaches to therapy [1:56:30]; Josh's hopeful outlook on the future of cancer treatment [1:59:00]; Nutritional approaches to cancer attenuation [2:00:15]; What makes Princeton University special [2:06:15]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube