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The provided text from the "Metabolism Made Easy" YouTube channel explains the critical role of oxygen in the Electron Transport Chain (ETC), a vital process for cellular energy production. It highlights how hypoxia, or a lack of oxygen, significantly inhibits the ETC, thereby reducing the output of ATP, the body's primary energy currency. This reduction in ATP can severely impair the function of aerobic tissues like the brain and heart, which heavily rely on oxygen-dependent pathways for energy. The source emphasizes that multiple mitochondrial catabolic processes that produce NADH and FADH2 will not generate usable energy in the absence of sufficient oxygen, ultimately leading to tissue damage, particularly in the brain, which is highly dependent on glucose oxidation for ATP.
The podcast describes the cellular role of the mitochondrial electron transport chain (ETC) and oxidative phosphorylation. This coupled oxidative process converts high energy molecules (NADH, FADH2) into a usable form of energy (ATP) by transporting their electrons to oxygen through the ETC. Oxygen consumption by the ETC accounts for the major cellular use of oxygen by the cell.
Errata Corrige: - al minuto 27:55 la membrana mitocondriale disegnata é quella interna (e non esterna) su cui sono disposti i trasportatori specifici per i sistemi navetta. Infatti le molecole di NADH sono permeabili alla MME grazie a delle proteine canale chiamate porine. - al minuto 25:10 il rapporto P/O=2 é la quantità di ATP sintetizzata per atomo, e non molecola, di ossigeno (secondo le definizioni). All'atto pratico però la molecola di ossigeno non viene rilasciata dal complesso IV della catena respiratoria finché non viene completamente ridotta, per cui il rapporto P/O sarebbe uguale a 4 (considerando O come molecola) per 2 equivalenti di FADH2 ossidati. Rispiego riassumendo il concetto espresso al minuto 28:46: una molecola di NADH ha un rapporto P/O più alto rispetto ad una molecola di FADH2 perché l'energia rilasciata dagli equivalenti riducenti durante il loro trasporto attraverso la catena respiratoria aziona più pompe protoniche (in particolare, quelle del complesso I, III e IV) e quindi, in proporzione, concorre maggiormente a determinare quel gradiente di concentrazione che viene utilizzato come fonte di energia dal complesso V, ATP-sintesi, per sintetizzare ATP.LINK RAPIDI:00:00 INTRODUZIONE00:43 DIGESTIONE E ASSORBIMENTO02:17 LA GLICEMIA E IL SUO CONTROLLO ORMONALE06:55 INGRESSO DEL GLUCOSIO NELLE CELLULE. I TRASPORTATORI DEL GLUCOSIO11:37 GLICOLISI E LA SUA REGOLAZIONE23:20 RESA ENERGETICA DELLA GLICOLISI
Joris Koptod Nioky is filmmaker. Hij werkte meer dan twintig jaar in de culturele sector, onder andere als fotograaf, schrijver en muzikant, voordat hij in 2020 zijn debuut als regisseur maakte. Dat deed hij met ‘Portret van een mislukt schrijver'. Hij won daarmee de Filmprijs van de Stad Utrecht. In 2021 volgde zijn tweede film ‘Dit ben ik niet'. Daarvoor trok hij in bij zijn moeder Rian (71) om haar te laten reflecteren op het moederschap. Joris gebruikt zijn film om Rian te confronteren met de trauma's van het verleden, waar zij zich, na het zien van een tussentijdse montage, totaal niet in herkent. In zijn nieuwe film ‘Zoekjaar' bevraagt Nioky de Nederlandse bureaucratie. Hij volgt Chinese performancekunstenaar Nadh, die na het behalen van zijn diploma op een Nederlandse kunstacademie precies één jaar de tijd krijgt om een baan te vinden - zijn ‘zoekjaar' - anders moet hij weg uit Nederland. Joris Koptod Nioky volgt Nadh en houdt de kijker een spiegel voor: je kunt je naar de regels voegen, maar je kunt ze ook bevragen of verwerpen. Femke van der Laan gaat met Joris Koptod Nioky in gesprek.
RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista GlaísePalma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.
Is your inner critic running the show? What if the voice inside your head isn't even yours—but a residue of trauma, stress, or dysfunction? In this eye-opening episode of Healthy Waves, host Avik dives deep into the science behind cellular healing with Claire Martinsen, CEO of Biobloom Injectables. Claire breaks down the truth about NADH and B12—how these molecules work at the mitochondrial level to support energy, mental clarity, emotional regulation, and trauma recovery. We explore how NADH + B12 injections can outperform oral supplements, support therapy and somatic work, and offer real, bioavailable healing—not just hype. Claire shares her personal journey of transformation, including relief from ADHD symptoms, hormonal imbalances, and chronic fatigue—all by supporting her cells instead of suppressing symptoms. This isn't just about wellness trends—it's molecular repair from the ground up. Whether you're a high achiever on the edge of burnout or someone healing from trauma, this episode offers powerful, science-backed insights for real transformation. ABOUT THE GUEST:Claire Martinsen is the CEO of Biobloom Injectables, a science-driven wellness company focused on bioavailable solutions for mental clarity, energy, and healing. With a background in biology and public health, Claire bridges cutting-edge research with practical application, helping people unlock their potential—cell by cell. KEY TAKEAWAYS: NADH (Nicotinamide Adenine Dinucleotide + Hydrogen) is a stable, bioavailable form that supports cellular energy (ATP production), brain health, and DNA repair. Unlike NAD+, which needs conversion and loses potency through digestion, NADH IM injections bypass the gut and deliver 100% absorption. Combined with methylated B12, NADH boosts dopamine, serotonin, and oxygenation in the brain—enhancing focus, mood, and nervous system resilience. Claire shares how NADH helped with her ADHD, back pain, gluten intolerance, immune response, and hormonal balance—without side effects. Bioavailable supplements like NADH+B12 complement trauma therapy and somatic work by stabilizing the nervous system and accelerating healing. Biobloom Injectables is committed to accessible wellness grounded in science, with transdermal patches and sublingual formats underway. Claire's mission is rooted in loss—creating this work in honor of her best friend who died by suicide. Her goal is to make mental wellness and biological repair available to all. CONNECT WITH THE GUEST:Claire Martinson is available on all social platforms under @wheretoclaire. Her company, BioBloom Injectables, offers services globally, including in India. Visit her page or reach out via social to learn more about her wellness offerings and research-backed products. WANT TO BE A GUEST ON HEALTHY MIND, HEALTHY LIFE?DM on PodMatchDM Me Here:https://www.podmatch.com/hostdetailpreview/avik CHECK PODCAST SHOWS & BE A GUEST: Tune to all our 19 podcasts: https://www.podbean.com/podcast-network/healthymindbyavik Subscribe To Newsletter: https://healthymindbyavik.substack.com/ Join Community: https://nas.io/healthymind OUR SERVICES Business Podcast Management - https://ourofferings.healthymindbyavik.com/corporatepodcasting/ Individual Podcast Management - https://ourofferings.healthymindbyavik.com/Podcasting/ Share Your Story With World - https://ourofferings.healthymindbyavik.com/shareyourstory STAY TUNED AND FOLLOW US!Medium - https://medium.com/@contentbyavikYouTube - https://www.youtube.com/@healthymindbyavikInstagram - https://www.instagram.com/healthyminds.pod/Facebook - https://www.facebook.com/podcast.healthymindLinkedIn Page - https://www.linkedin.com/company/healthymindbyavikLinkedIn - https://www.linkedin.com/in/avikchakrabortypodcaster/Twitter - https://twitter.com/podhealthclubPinterest - https://www.pinterest.com/Avikpodhealth/ SHARE YOUR REVIEW Share your Google Review - https://www.podpage.com/bizblend/reviews/new/ Share a video Testimonial - https://famewall.healthymindbyavik.com/ #podmatch #healthymind #healthymindbyavik #NADH #biohacking #mentalhealthpodcast #neuroscience #B12 #healingjourney #traumarecovery #mindbodyconnection #wellnessjourney #selfcare #mitochondria #consciousliving #mentalhealthawareness #podcastlife #newpodcast #trending #youtube #wellbeing #mindfulness #healthandwellnesspodcast #HealthyMindHealthyLife
RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.
Energy and longevity in a single molecule!? That almost sounds too good to be true. In the latest episode of the INUMED Podcast, listen to an expert discussion about a naturally occurring substance in the human body that combines both: Panmol® NADH - essentially the ying and yang of our metabolism. This episode explores what exactly this “miracle nutrient” is, where it can be found, and what the catch might be. And, more importantly, how that catch can be overcome - once again, with the help of natural plant-based compounds. People who should pay close attention include those with mental or physical performance issues, such as chronic fatigue, excessive tiredness, concentration difficulties, dementia, depression, liver weakness, as well as athletes and mental performers looking to improve their performance. But let's be honest: Who among us wouldn't like to have more energy? _ DAS MILIEU IST DER SCHLÜSSEL ZUR GESUNDHEIT _ www.INUMED.at www.NUTRIBIOTICUM.com _ Die Empfehlungen in diesem Podcast sind auf dem neuesten Stand der ernährungs- und sportmedizinischen Wissenschaft sie ersetzen jedoch im Krankheitsfall nicht die ärztliche Konsultation. Im Zweifelsfall konsultieren Sie bitte einen erfahrenen Ernährungs- oder Ganzheitsmediziner.
In Episode 27, we wrap up our Metabolism series by diving into one of the most testable—and often misunderstood—topics on the MCAT: The Electron Transport Chain (ETC) and Oxidative Phosphorylation.We cover everything you need to know for MCAT success:
Ready to move beyond glycolysis? In Episode 26 of the Jack Westin MCAT Podcast, Mike and Molly guide you through the Pyruvate Dehydrogenase Complex (PDC) and the Citric Acid (TCA) Cycle—two of the highest‑yield pathways the MCAT loves to test.What we cover- Where it all happens – cytoplasm vs. mitochondrial matrix- PDC outputs & regulation – 2 Acetyl‑CoA, 2 NADH, 2 CO₂ and the key activators/inhibitors that flip the complex on or off- Real‑world connections – how arsenic poisoning and Wernicke‑Korsakoff syndrome derail PDC function- TCA Cycle essentials – step‑by‑step walk‑through, enzyme mnemonics (“Can I Keep Selling Shells…”) and the must‑know Big 3 regulators- High‑yield nuggets – why Succinate Dehydrogenase pulls double duty as ETC Complex II, Ca²⁺ activation during muscle contraction, plus glucogenic vs. ketogenic amino acid entry pointsBy the end, you'll know the exact products (NADH, FADH₂, GTP, CO₂), how to spot test‑maker tricks, and which regulatory enzymes to memorize for test day.
RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista GlaísePalma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.
In this week's Jack Westin MCAT Podcast, Mike and Molly pull glycolysis out of the rote-memorization zone and rebuild it as a story you can see, explain—and defend—on test day. Starting with the big-picture difference between aerobic and anaerobic metabolism, they zoom into the 10 classic steps, spotlight why hexokinase and especially PFK-1 are the pathway's “no-turning-back” moments, and finish with the hormonal signals that flip glycolysis on or off in real life. Along the way they debunk lactic-acid myths, link fasting physiology to MCAT passages, and hand you regulation mnemonics that actually stick.Key takeaways at a glance- Net yield, location & oxygen: Cytoplasmic pathway that nets 2 ATP, 2 NADH, 2 pyruvate—no O₂ required.- Energy investment vs. payoff: Why you spend 2 ATP up front and gain 4 later (+2 net).- Regulation checkpoints: Steps 1, 3 & 10 are irreversible; PFK-1 is the commitment step; ATP inhibits, ADP/AMP activate.- Hormonal control: Insulin (via PFK-2) ramps glycolysis up; glucagon turns it down—crucial in fed vs. fasting states.- Clinical & exam links: Cori cycle, muscle soreness myth, and how enzymes like hexokinase signal MCAT question writers.Next episode: PDH complex, electron-transport chain, and oxidative phosphorylation—subscribe so you're ready for the hand-off from glycolysis to ATP powerhouse.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!
RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.
The episode opens with an in-depth discussion about the value of open source as a model of development and how the definitional contours of open-source AI differ from those of traditional open-source software. The discussion also explores the characteristics and challenges that distinguish open-source AI models from conventional software development approaches.The discussion goes on to address recent strategic shifts in the AI industry towards more open development, sparked by developments like DeepSeek's open-source R1 model and leaked internal assessments suggesting that open-source communities may be outpacing tech giants.The discussion also explores the complex trade-offs between open and closed AI development. While open-source models offer transparency, democratization, and innovation benefits, they also present cybersecurity vulnerabilities and potential national security risks. Nadh addresses concerns about jailbreaking vulnerabilities in open models, using DeepSeek's recent security lapses as an example, while also examining the limitations and risks of closed proprietary systems.Nadh also provides his perspective on India-specific considerations, including the government's IndiaAI Mission and the decision to develop a homegrown large language model, and discuss the strategic implications of India's approach, which is not expected to be open-source at first, and the potential for India to make meaningful progress in driving open-source AI development as a matter of policy. Episode Contributors Kailash Nadh is the chief technology officer of Zerodha, India's leading stock brokerage platform, where he has led its technology and product stack development since 2013. He is also the co-founder and director of FOSS United, a non-profit foundation based in Bangalore, that aims to provide grassroot support to free and open-source software projects and communities in India. In addition to being a full-stack software developer with more than two decades of technical experience, Nath holds a PhD in artificial intelligence and computational linguistics. His most recent writings also provide a compelling analysis of open-source software developments and AI breakthroughs, including in the Indian context. Shruti Mittal is a research analyst at Carnegie India. Her current research interests include artificial intelligence, semiconductors, compute, and data governance. She is also interested in studying the potential socio-economic value that open development and diffusion of technologies can create in the Global South. Every two weeks, Interpreting India brings you diverse voices from India and around the world to explore the critical questions shaping the nation's future. We delve into how technology, the economy, and foreign policy intertwine to influence India's relationship with the global stage.As a Carnegie India production, hosted by Carnegie scholars, Interpreting India, a Carnegie India production, provides insightful perspectives and cutting-edge by tackling the defining questions that chart India's course through the next decade.Stay tuned for thought-provoking discussions, expert insights, and a deeper understanding of India's place in the world.Don't forget to subscribe, share, and leave a review to join the conversation and be part of Interpreting India's journey.
RESpiros em Saúde Mental é uma produção do Núcleo de Apoio à Diversidade Humana junto à Radio Web UFN. O programa pretende discutir temas atuais da saúde mental com especialistas na área. Mediação da jornalista Glaíse Palma, com participação fixa do psicólogo, professor e coordenador adjunto do NADH, Dr. Félix Guazina. Na técnica Clenilson Oliveira e Emanuelle Rosa na identidade visual.
Dr. Amanda Williams discusses the anti aging effects of Creatine and NADH.Jerry Hickey discusses the power of Grape Seed and Bio-curcumin.
Energie und Langlebigkeit in einem Molekül!?? Das klingt beinahe zu schön, um wahr zu sein. Hören sie in der aktuellen Folge der INUMED Sprechstunde ein Expertengespräch über einen körpereigenen Stoff, der beides vereint. Panmol® NADH, quasi das Ying und das Yang unseres Stoffwechsels. Worum es sich bei diesem Wunderwuzzi unter den Nährstoffen handelt, wo es vorkommt und wo der Haken an der ganzen Geschichte ist, wird ebenso erörtert, wie auch die Frage, wie dieser Haken zu lösen ist. Nämlich wieder einmal durch natürliche Pflanzenstoffe. Besonders gut zuhören sollten Menschen mit mentalen oder körperlichen Leistunsgschwächen, wie z.B. Chronic Fatigue und übermäßiger Ermüdbarkeit, Konzentrationsschwächen, Demenz, Depressionen, Leberschwäche, aber auch Sportler und Denkakrobaten, die Ihre Leistung verbessern möchten. Aber, mal ehrlich: Wer von uns hätte nicht gerne mehr Energie zur Verfügung?“ Zur Studie: https://www.inumed.com/files/pdf/240434_10-1055-a-2257-6314_Authors%20Offprint.pdf Rösler D, Fuchs N, Markolin G, Edler B, Sauer L, Studer M: Einfluss einer NADH-haltigen Nährstoffkombination auf Gedächtnis, Konzentration und Grundstimmung. OM & Ernährung 2008; 125: F20-F25 Zum Produkt: https://shop.nutribioticum.com/mangelausgleich/nadh_akg_creatin.html _ DAS MILIEU IST DER SCHLÜSSEL ZUR GESUNDHEIT _ www.INUMED.at www.NUTRIBIOTICUM.com _ Die Empfehlungen in diesem Podcast sind auf dem neuesten Stand der ernährungs- und sportmedizinischen Wissenschaft sie ersetzen jedoch im Krankheitsfall nicht die ärztliche Konsultation. Im Zweifelsfall konsultieren Sie bitte einen erfahrenen Ernährungs- oder Ganzheitsmediziner.
SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMEn este episodio Patri Psicóloga nos explica que pensar mucho no siempre equivale a pensar mejor, que la ansiedad tiene muchas caras y que ocuparnos de todo se paga con la salud física y mental. Si te gusta el episodio y quieres vernos en directo en el teatro, compra tus entradas en www.patripsicologa.com/teatroEn abril el mecenas es el complemento alimenticio NADH de HSN. Seguro que has oído hablar del NAD. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan un 65% entre los 30 y 70 años. Y eso se nota: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como dar un empujón a tu energía celular. Puede ayudar a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud. Llévate de regalo* una botella HSN de acero inoxidable en pedidos superiores a 79 euros. Usa el cupón CRISMITRE. *Regalo disponible hasta fin de existencias. No acumulableInstagram @thebeautymailTwitter @cristinamitreYouTube https://www.youtube.com/c/CristinaMitreLinkedIn Cristina Mitre ArandaFacebook https://www.facebook.com/CrismitreTrack: "Walk!", lov3rMusic provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/d64537c5-4d7f-4ac4-87b0-4bc2fd228abd?utm_source=attributionListen on Spotify: https://go-stream.link/sp-lov3rTrack: "Latin Party.-Instrwav"Music provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/cb324323-0998-4319-a5c0-8c9380be5c33 Hosted on Acast. See acast.com/privacy for more information.
SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMComer sano no es hacer dietas extremas, ni pasar hambre, ni vivir sin pan toda la vida. Es aprender a elegir, organizarse y disfrutar de todos los grupos de alimentos sin miedo. ¿Y lo mejor? No tiene por qué ser caro. Nos lo va a contar Jessica Hierro en este episodio.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.
SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COM¿Es posible tener un problema con el alcohol sin darse cuenta? El alcohol forma parte de nuestra vida: nos reunimos en torno a él, lo asociamos con relax, descanso o fiesta. Pero esa normalización puede esconder una realidad compleja: la adicción al alcohol. Y no siempre tiene la forma que imaginamos. Bajo una apariencia “normal”, muchas personas sufren dependencia del alcohol. El Dr. Gabriel Rubio, jefe de Psiquiatría del hospital 12 de Octubre, especializado en tratamiento del alcoholismo, nos va a mostrar cómo se inicia la adicción al alcohol, cómo cambia con los años, qué impacto tiene en la persona y su familia, qué supone recuperarse o qué papel juegan la vergüenza y la culpaEn abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.
Hey, welcome back! Today, we're diving into something that can seriously up your game when it comes to energy, performance, and even longevity—NAD+. If you haven't heard of it, don't worry, we've got you covered. We're also going to talk about some awesome peptide stacks that can keep you feeling energized and performing at your best—whether that's crushing it in your workouts or staying sharp through your workday grind. So, if you're looking to boost your fitness, stay more focused at work, or just feel more energized in general, this episode's for you. What is NAD+? Alright, let's kick things off with the basics—what is NAD+? It stands for Nicotinamide Adenine Dinucleotide, which is a bit of a mouthful, but it's actually a co-enzyme that's super important for energy production in your body. Think of it as the fuel for your cells. Without NAD+, your cells can't make energy, which is obviously a big deal. Now, here's the thing—our NAD+ levels drop as we get older. This can lead to feeling tired, slower recovery, and just a general lack of energy. But don't panic—there's good news! Supplementing with NAD+ (either through injections or IV infusions) or even helping your body boost its NAD+ production naturally can actually reverse some of these aging effects. Not only will you feel more energized, but you'll also get benefits like improved focus, better endurance, faster recovery, and even some anti-aging perks. How Does NAD+ Work? So, how does NAD+ actually work in the body? It plays a huge role in energy production by helping with mitochondrial respiration. Basically, it cycles between two forms—NAD+ and NADH—to help produce ATP, which is the energy currency of your cells. But that's not all. NAD+ also impacts proteins called sirtuins that regulate metabolism, stress responses, and longevity. It even activates enzymes like PARPs that help with DNA repair, which is key for maintaining cell integrity, especially when dealing with things like aging and stress. And on top of that, NAD+ is involved in cell signaling pathways that influence things like inflammation, insulin sensitivity (which could help with weight management), and even your circadian rhythm. What Are the Benefits of NAD+? So, you've got energy, anti-aging, and DNA repair—but that's just the start. NAD+ can also help with memory, focus, and mental clarity by keeping your neurons healthy and protected from neurodegeneration. In fact, there's some research showing that NAD+ therapy could even help with managing withdrawal symptoms and cravings, particularly for alcohol and opioid dependencies. Are There Any Side Effects of NAD+? Like anything, NAD+ therapy can have some side effects, though it's generally considered safe. Some people may experience things like low blood pressure, flushing, nausea, headaches, or fatigue, especially after an injection. But the good news is these side effects tend to go away on their own, and over time, your energy levels will start to improve. Let's Talk About Stacking NAD+ for Even More Benefits Okay, so you're probably wondering how to make the most of NAD+. Well, stacking it with the right supplements can seriously amplify its effects. But it's not just about throwing a bunch of stuff together and hoping for the best. You've got to have the right combos to really level up your energy, endurance, and focus. Here are my top four NAD+ stacks: NAD+ + Glutathione This stack is great for detoxing and reducing oxidative stress. It supports your cellular health and helps fight free radicals, which is key for feeling good and staying healthy long-term. NAD+ + 5 Amino-1MQ If you're looking to support metabolic health and fat loss, this one's for you. 5 Amino-1MQ is a peptide that works really well with NAD+ to boost fat-burning and improve metabolic efficiency. NAD+ + Thymosin Alpha-1 Thymosin Alpha-1 is a peptide that's all about boosting your immune system. When combined with NAD+, it enhances your immune-regulating effects, making it a powerful duo for longevity and immune resilience. NAD+ + Epitalon Epitalon is a peptide that helps with telomere health, which is essential for anti-aging. When paired with NAD+, it supports cellular repair and overall longevity. If you're thinking about adding NAD+ to your routine, I'd recommend starting with a high-quality supplement. Take it consistently, pair it with the right stacks, and give it a bit of time to work its magic. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
What are the pros, cons, and efficacy of dihydronicotinamide riboside (reduced NR), perhaps the most potent NAD+ precursor, as well as reduced NMN, taking NAD+ directly, or making it from scratch from tryptophan?
SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMHoy vamos a hablar de amor propio con todo un experto: Walter Riso. Si miras su web verás que trabaja desde hace treinta años como psicólogo clínico y formador de terapeutas, práctica que alterna con el ejercicio de la cátedra universitaria en Latinoamérica y España, y la publicación de textos científicos y de divulgación, en diversos medios. Ha publicado 30 libros, entre textos técnicos y de divulgación, que han sido traducidas a más de 20 idiomas. Hoy vamos a profundizar con él en los temas de su último libro, Los siete pilares del amor propio, cuya lectura es más que recomendable para mejorar la relación que tienes con la persona más importante de tu vida: TÚ.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.
Story at-a-glance High blood sugar in Type 2 diabetes overwhelms cellular machinery like a chaotic factory, creating not just oxidative stress as previously thought, but also a more fundamental problem called reductive stress. Reductive stress occurs when there's an oversupply of electron-carrying molecules in cells, creating a "traffic jam" of electrons that can't be processed efficiently by the mitochondria's electron transport chain While traditional views focused on oxidative stress alone, scientists now understand that reductive stress actually triggers oxidative stress. It's the initial spark that sets off a chain reaction of cellular damage in diabetic conditions When the main pathway for processing glucose becomes blocked due to reductive stress, sugar molecules get diverted into harmful alternative pathways, creating additional toxic byproducts and inflammation The combination of reductive and oxidative stress explains many serious complications of diabetes including neuropathy, retinopathy, nephropathy, and cardiovascular problems — all stemming from this initial electron overload Understanding reductive stress offers new therapeutic possibilities. Instead of just focusing on lowering blood sugar or fighting oxidative damage after it occurs, effective treatments target the electron transport chain efficiency and/or help cells recycle NADH more effectively
Red blood cells are entirely dependent on glucose as their only energy source. Glucose is utilized in glycolysis to produce the ATP output required by the red blood cell because red blood cells lack mitochondria, which would metabolize pyruvate to CO2 in other cells. The glycolytic output of energy from glucose breaking down to two lactates will produce two ATPs only because the NADH produced from the glyceraldehyde 3-phosphate dehydrogenase step of glycolysis will be consumed in the conversion of two 2-pyruvates to two lactates. Check out the original short on glucose and red blood cells below: https://youtube.com/shorts/nbEF42DaAko?feature=share
Guest Kailash Nadh Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard Littauer sits down with Kailash Nath, CTO of Zerodha, to delve into the dynamics of funding and sustaining open-source projects. They explore the establishment of Zerodha's FLOSS/Fund, which allocates a million dollars annually to support pivotal open source projects and discuss the development of the funding.json format to streamline grant applications. The conversation also covers the challenges of creating such funds, including regulatory hurdles, and aims to make financial assistance globally accessible. From detailing efforts to revive India's open-source communities through the FOSS United Foundation to highlighting the obstacles and innovative models in funding open-source software, the episode provides a comprehensive look at both global and Indian perspectives. Hit download now! [00:01:14] Richard brings up the FLOSS/Fund, a $1 million annual commitment to open source projects. Kailash confirms that the fund is still active and explains how it recently became more structured and a small team has been formed to manage the logistics of the fund. [00:02:48] The FLOSS/Fund has been created to publicly commit to supporting open source in a structured way. Kailash points out that while other companies give donations to open source, there are few structured initiatives from large organizations. [00:04:33] Kailash expresses frustration that few billion-dollar companies have set up similar initiatives to support open source projects. [00:06:24] Kailash explains that the FLOSS/Fund is open to the global open source community and target systemically important projects like libraries and widely used software tools. [00:08:14] Richard inquires about the application process and Kailash explains instead of traditional grant forms, projects must create and publish a “funding.json” file. [00:10:35] Kailash shares that the structured application method is designed to avoid the usual awkwardness of fundraising conversations and streamline the process. [00:13:31] The two discuss the difficulty maintainers face when articulating the importance of their projects, particularly for maintainers who may not have strong written communication skills, Kailash emphasizes that the funding.json method does not replace narrative descriptions but simplifies signaling. [00:16:17] The conversation switches to global scope and prioritization as Kailash tells us Zerodha's open source contributions are not limited to projects they directly use, the fund is open to all global projects, and Zerodha hopes to support projects that are crucial for open source infrastructure. [00:17:09] Kailash discusses the complexity of sending money internationally from India. [00:18:59] We learn the goal is not to make funding.json go viral through financial incentives, but to organically grow adoption if the tool proves valuable. [00:20:49] Richard and Kailash explore the broader challenges of sustaining open source projects beyond funding, such as building healthy communities and incentivizing the proper use and citation of open source infrastructure. [00:25:32] Kailash discusses the Indian open source ecosystem. [00:30:29] Kailash explains how Zerodha's initiatives aim to push the Indian industry to give back more to the open source community. He hopes that their efforts will inspire other companies to set up similar initiatives. [00:32:12] Find out where you can donate to Floss fund and follow Kailash online. Spotlight [00:32:56] Richard's spotlight is his first grade teacher, Mrs. Barril. [00:33:25] Kailash's spotlight is Jim Martsolf who introduced him to “webmastering.” Links SustainOSS (https://sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) richard@sustainoss.org (mailto:richard@sustainoss.org) SustainOSS Discourse (https://discourse.sustainoss.org/) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Kailash Nadh LinkedIn (https://www.linkedin.com/in/kailashnadh/) Kailash Nadh Website (https://nadh.in/) Zerodha (https://zerodha.com/) funding.json (https://floss.fund/funding-manifest/) Sustain Podcast-Episode 153: Kailash Nadh and the FOSS United Foundation (https://podcast.sustainoss.org/153) FLOSS/Fund (https://floss.fund/) FFmpeg (https://ffmpeg.org/) Zig (https://ziglang.org/) Sustain Podcast-Episode 247: Chad Whitacre on the Open Source Pledge (https://podcast.sustainoss.org/247) Open Source Pledge (https://opensourcepledge.com/) Announcing FLOSS/fund: $1M per year for free and open source projects-post by Kailash Nadh (https://floss.fund/blog/announcing-floss-fund/) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Kailash Nadh.
Geburtstagsspecial: Insights zu Romans liebsten Produkten für mehr Energie und Wohlbefinden Heute habe ich einen ganz besonderen Gast: meinen Mann Roman Gruber. Gemeinsam sprechen wir über sein exklusives Geburtstagsbundle, das einige seiner Lieblingsprodukte enthält. Im Fokus stehen der Faceformer, das Energy, das Colostrum Strong Flüssig und das Magnesiumtaurat. Roman erläutert, warum gerade diese Produkte zu seinen Favoriten gehören und welche Vorteile sie bieten. Zudem geben wir spannende Einblicke in die Anwendung und Wirkung dieser Produkte. Romans Lieblingsproduktebundle FACEFORMER - Ein innovatives Trainingsgerät, das die Nasenatmung und die Muskelentwicklung im Gesichtsbereich verbessert. Besonders hilfreich bei Schnarchen und Stressabbau ENERGY - Ideal für Menschen, die einen Energieboost benötigen oder an Migräne leiden. Enthält Q10 und NADH für die Unterstützung der Mitochondrien FLÜSSIGES COLOSTRUM - Ein unverzichtbares Notfallprodukt zur Stärkung des Immunsystems. Perfekt für akute Situationen wie Halsschmerzen oder Hautprobleme MAGNESIUMTAURAT - Eine besonders gut aufnehmbare Form von Magnesium, die auch nicht zu Durchfall führt, wie das bei anderen Magnesiumpräparaten der Fall sein kann LINKS Romans Lieblingsproduktebundle: https://shop.arktisbiopharma.ch/romans-lieblingsprodukte-bundle/B-014 Magnesiumtaurat: https://shop.arktisbiopharma.ch/mgt-magnesiumtaurat-kapseln/110380-6er Colostrum Strong: https://shop.arktisbiopharma.ch/colostrum-strong-125-ml/360000 Faceformer: https://shop.arktisbiopharma.ch/faceformer-zero/DI-FF-GPR-V Energy: https://shop.arktisbiopharma.ch/energy-q10-nadh-60-kps/100309-6er Energy im Fokus: Roman Gruber im Interview über das neue Produkt mit Q10 und NADH (DG229) - https://arktisbiopharma.ch/energy-im-fokus-roman-gruber-im-interview-ueber-das-neue-produkt-mit-q10-und-nadh-dg229/ Uwe Gröber über Magnesium und Magnesium-Taurat – Wichtige Erkenntnisse eines Mikronährstoffexperten (DG269) - https://arktisbiopharma.ch/uwe-groeber-ueber-magnesium-und-magnesium-taurat-wichtige-erkenntnisse-eines-mikronaehrstoffexperten-dg269/ Die Folgenotizen und eine schriftliche Zusammenfassung zu dieser Episode findest du unter: https://www.arktisbiopharma.ch/279 Als Podcasthörer:in bekommst du von uns einen Rabatt auf unsere Produkte. Und zwar 15% Rabatt auf deinen ersten Einkauf (1-mal anwendbar, nur auf nicht bereits rabattierte Produkte). Der Gutscheincode ist in beiden Arktis BioPharma Shops in der SCHWEIZ und in DEUTSCHLAND gültig. Gib hierfür den Gutscheincode podcast15 ein, bevor du deine Bestellung abschliesst. https://shop.arktisbiopharma.ch https://arktisbiopharma.de/ Abonniere den Darmglück-Podcast in deiner Lieblings-Podcastapp (Apple Podcasts, Spotify, Deezer, Google Podcasts etc.), indem du “Darmglück” in die Suche eingibst.
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Danny's Website: https://t.me/dannyroddy Danny's Substack: https://dannyroddy.substack.com/ Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson's Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson's Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson's Blueprint and how to measure health 32:39 – Bryan Johnson's supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall's response to our take on glucagon and insulin 1:24:17 – glucagon's short-term and long-term effects on metabolic function 1:26:46 – glucagon's role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health
In this episode, we delve into a revolutionary longevity molecule that you might not have heard of before: 1-MNA. If you're interested in staying younger longer and if you want to maintain your energy and vitality then this is an episode for you. Perhaps you have read the groundbreaking book by Dr David Sinclair "Lifespan" where he talks about NAD and how crucial it is for the body and how it can help upregulate sirtuin genes (longevity genes) and help you maintain your cellular health and energy. We are now 4 years on we have more data, studies and information to share in this arena. Perhaps you have been trying to improve your NAD metabolism, taking NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside), and upregulating sirtuin genes, if you have then you need to hear this. We'll explore the intricacies of NAD pathways, the role of key enzymes, and why simply supplementing with NAD precursors may not be the best holistic approach and how we can improve on that approach to anti-aging Key Points Discussed: Introduction to NAD Metabolism: Overview of previous episodes on NAD metabolism with experts like Professor Joseph Baur, Dr. Elizabeth Yurth from the Boulder Longevity Institute, and Dr. Elena Seranova. Importance of understanding the complexities of NAD pathways beyond the basics. Understanding 1-MNA: Explanation of 1-MNA and its role in controlling NAD levels by blocking the enzyme NNMT (Nicotinamide N-methyltransferase). The dangers of upregulating NNMT, which degrades NAD and can lead to various health issues. Key Enzymes in NAD Metabolism: Discussion on the salvage pathway and two critical enzymes that degrade NAD. Importance of regulating NNMT to prevent its deleterious effects, particularly in senescent cells, cancer cells, and fat cells. Benefits of 1-MNA How 1-MNA can help maintain a balanced NAD metabolism by inhibiting NNMT. Potential benefits for conditions like schizophrenia, neurodegeneration, liver diseases, and cancer. Research and Studies: Overview of studies showing the positive effects of 1-MNA on post-COVID conditions, inflammation, and mitochondrial function. Insights from animal studies on 1-MNA's protective effects against metabolic disorders. Practical Applications: Recommendations for integrating 1-MNA into supplement regimens, especially for those taking NMN or NR. Potential benefits for various conditions, including obesity, metabolic syndrome, cardiac disease, liver disease, cancer risk, long COVID, and fatigue. Balancing NAD Levels: Importance of maintaining NAD levels for energy production, DNA repair, neurotransmitter health, and longevity. The role of NAD as a redox molecule and the balance between NAD+ and NADH. Conclusion: Encouragement to explore further research on NNMT and its impact on health. Final thoughts on the potential of 1-MNAas a crucial supplement for maintaining NAD balance and promoting longevity. References and Links: Boulder Longevity Institute: https://boulderlongevity.com/ SSRP Institute: https://ssrpinstitute.org/ Studies on NNMT and related conditions: Research If you enjoyed this episode, please give it a like, share, and subscribe to the YouTube channel. Tune in weekly for more interviews with top doctors and scientists on health optimization and longevity. Get Your 1-MNA now If you want to start supplementing with 1-MNA to support your own healthy aging journey, to upregulate your NAD metabolism, support sirtuin genes and prevent the overexpression of the deleterious NNMT Enzyme you can buy it here: 1-MNA and use code NAD to get $25 off your first order Stay up-to-date with the latest research and evolve with the science to optimize your health and longevity. See you in the next episode! Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38 Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa and team
The world of detox supplementation, debunking common misconceptions and highlighting its crucial role in maintaining optimal health. Detox supplements are explained as essential providers of nutrients necessary for the body's detoxification processes, rather than direct detoxifiers. Using relatable analogies like baking a cake, the discussion emphasizes the importance of addressing nutritional deficiencies to support natural detox pathways. The video also explores the impact of reduced nutrient values in food and increased exposure to environmental toxins, which elevate the need for proper supplementation.The dangers of neglecting detox supplementation, especially when using potent substances like semaglutide and other anabolic agents, are highlighted. Balancing supplement intake to support organ function during detoxification and boost levels of vital compounds like glutathione and NADH is underscored. Rooted in chiropractic and natural health principles, the video advocates for a holistic approach to health, where providing the body with necessary chemicals allows it to perform its natural detoxification processes effectively. This comprehensive guide underscores the significance of detox supplements in supporting overall well-being.Highlights of the Podcast00:05 - Introduction to Detox Supplementation00:30 - Misconceptions About Detox Supplements01:10 - Role of Nutrients in Detoxification01:37 - Analogy for Understanding Nutrient Deficiency02:30 - Decreasing Nutrient Values in Food03:19 - Increased Toxic Load and Stress04:10 - Function of Detox Supplements04:43 - Impact of Supplements on Pathogens05:00 - Balancing Supplement Intake06:10 - Danger of Ignoring Detox Supplements08:11 - Role of Glutathione in Detoxification09:00 - NADH and Its Functions09:36 - Philosophy of Detoxification10:30 - Counterargument to Detox Supplement Skepticism11:15 - Conclusion and Call for Questions
In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive. We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan. Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk. Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor 01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy 02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
In this episode of The Metabolic Classroom, Dr. Bikman introduces the concept of the Randle Cycle, also known as the glucose fatty acid cycle, in a lecture aimed at providing a better understanding of metabolism. The Randle Cycle, first identified by Dr. Philip Randle and his colleagues in the 1960s, explores how cells decide between using glucose or fatty acids for fuel. Dr. Bikman emphasized that this cycle has been misinterpreted on social media and aims to clarify its relevance in metabolic functions and nutritional decisions.https://www.insuliniq.com 00:00 - Introduction to the Metabolic Classroom and Dr. Ben Bikman01:00 - Overview of the Randle Cycle (Glucose Fatty Acid Cycle)02:00 - Historical Background: Philip Randle's Research03:00 - Experimental Model: Perfused Rat Hearts04:00 - Key Terms: Glucose and Fatty Acids05:00 - Concept of Substrate Competition06:00 - Reciprocal Inhibition: Fats vs. Glucose08:00 - Fatty Acid Oxidation Process10:00 - Biochemical Pathways: Acetyl-CoA, NADH, and Pyruvate Dehydrogenase12:00 - Role of Citrate in Glycolysis Inhibition14:00 - Glucose Utilization and Malonyl-CoA16:00 - Insulin's Role in Fuel Selection18:00 - Insulin's Impact on Glucose and Fat Burning20:00 - Diabetes Case Study: Type 1 and Type 222:00 - Type 1 Diabetes: High Glucose and Fatty Acids24:00 - Ketones Production in the Liver26:00 - Type 2 Diabetes: Insulin Resistance and Metabolic Inflexibility28:00 - Insulin Resistance in Fat Cells30:00 - Metabolic Inflexibility in Type 2 Diabetes32:00 - Insulin Resistance in the Brain34:00 - The Impact on Hunger and Neurological Disorders36:00 - Conclusion: Importance of Insulin in Metabolic Health#Metabolism #RandleCycle #DrBenBikman #InsulinResistance #GlucoseMetabolism #FattyAcidOxidation #MetabolicHealth #DiabetesResearch #Ketosis #Type1Diabetes #Type2Diabetes #InsulinRole #CellBiology #NutritionalScience #MetabolicFlexibility #Ketones #GlucoseUtilization #FatBurning #BiomedicalScience #HealthLectureMy favorite meal-replacement shake: https://gethlth.com (discount: BEN10)My favorite electrolytes (and more): https://redmond.life (discount: BEN15)My favorite allulose source: https://rxsugar.com (discount: BEN20)References:https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/randle-cycle Insulin Regulation of Ketone Body Metabolism: https://onlinelibrary.wiley.com/doi/10.1002/0470862092.d0308The Effects of a Ketogenic Diet and Exercise Interventions on Cognitive Function: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.31.1_supplement.lb810(Due to character length constraints, not every reference is posted above. For a complete list, please email: support@insuliniq.com with your request.) Hosted on Acast. See acast.com/privacy for more information.
TheSugarScience Podcast- curating the scientific conversation in type 1 diabetes
Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Debjyoti Kundu at Indiana Biosciences Research Institute's as he shares his poster titled "Pivotal role of NADH:ubiquinone oxidoreductase assembly factor 8 in beta cell stress adaptation".
Tá bácús Harrington sa Neidín ag eirí as an ngnó. Deireadh ré don mbácús neamhspleach a bhí soláthar aráin sa chontae ó 1995
Episode 31: Biochem of Sports Nutrition | Cauliflower Taco Meat Welcome to the Diet NPO Podcast! Your pod for RD Exam and nutrition questions. Come listen this week as we discuss Biochemistry of Sports Nutrition combined with practice questions and some Cauliflower Taco Meat! 1. If an athlete is training and develops a higher VO2 max, they would be relying more on which of the following processes? A. Anaerobic Glycolysis B. Lactic Acid Cycle C. Creatine-Phosphate Pathway D. Aerobic Glycolysis 2. Under anaerobic conditions, pyruvate can be converted into ______ through the Cori Cycle and can then be converted to ______ through gluconeogenesis. : A. Lactate, Acetyl CoA B. Acetyl CoA, Glucose C. Lactate, Glucose D. Acetyl CoA, NADH 3. The pathway of aerobic metabolism that is producing the most amount of ATP through NADH and FADH intermediates, is known as the ________. A. Kreb's Cycle B. Citric Acid Cycle C. Aerobic Glycolysis D. Electron Transport Chain DM for your RD Exam tutoring needs! Instagram: @zak_snacks Threads: @zak_snacks Youtube: Zak Kaesberg MS, RDN
https://passionstruck.com/passion-struck-book/—Order a copy of my new book, "Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life," today! The book was picked by the Next Big Idea Club as a must-read for 2024, the winner of the Business Business Minds Best Book 2024, and shortlisted for the Eric Hoffer First Grand Prize.In this episode of Passion Struck, host John R. Miles interviews Oz Garcia, a trailblazer in nutritional science and healthy aging. Oz shares insights on the impact of nutrition on health, the importance of lifestyle choices, and the role of intermittent fasting in optimizing health and longevity. Oz emphasizes the significance of probiotics, prebiotics, and postbiotics for gut health and the benefits of supplements like NADH for energy and acetyl L-carnitine for brain function.Full show notes and resources can be found here: https://passionstruck.com/dr-oz-garcia-on-the-secrets-to-a-healthier-life/In this episode, you will learn: The Power of Intermittent Fasting: Insights from Oz GarciaUnraveling the Secrets to a Healthier Life with Oz GarciaUnderstanding the Importance of Sleep with Oz GarciaProbiotics, Prebiotics, and Postbiotics: Oz Garcia's Guide to Gut HealthNADH and Acetyl Carnitine: Oz Garcia's Energy-Boosting SupplementsBrain Health Essentials: Acetyl L-Carnitine and Alpha-GPC with Oz GarciaMagnesium for Better Sleep and Nutrient Absorption: Oz Garcia's RecommendationsAll things Oz Garcia: https://ozgarcia.com/SponsorsBrought to you by Indeed. Head to https://www.indeed.com/passionstruck, where you can receive a $75 credit to attract, interview, and hire in one place.Brought to you by Nom Nom: Go Right Now for 50% off your no-risk two week trial at https://trynom.com/passionstruck.Brought to you by Cozy Earth. Cozy Earth provided an exclusive offer for my listeners. 35% off site-wide when you use the code “PASSIONSTRUCK” at https://cozyearth.com/This episode is brought to you by BetterHelp. Give online therapy a try at https://www.betterhelp.com/PASSIONSTRUCK, and get on your way to being your best self.This episode is brought to you By Constant Contact: Helping the Small Stand Tall. Just go to Constant Contact dot com right now. So get going, and start GROWING your business today with a free trial at Constant Contact dot com.--► For information about advertisers and promo codes, go to:https://passionstruck.com/deals/Catch More of Passion StruckWatch my interview with Dr. Anthony Youn On How To Feel Great And Look Your BestCan't miss my solo episode on The Reverse Aging Effect: How To Stay Young And HealthyListen to my episode with Dr. Kara Fitzgerald On How To Become A Younger You By Reversing Your Biological AgeMy solo episode on The Science Of Healthy HabitsCan't miss my episode with Dr. Mark Hyman On How Personalized Medicine Is Revolutionizing HealthcareLike this show? Please leave us a review here-- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally!How to Connect with JohnConnect with John on Twitter at @John_RMiles and on Instagram at @john_R_Miles.Subscribe to our main YouTube Channel Here: https://www.youtube.com/c/JohnRMilesSubscribe to our YouTube Clips Channel: https://www.youtube.com/@passionstruckclips
Ceoltóirí ó bhunscoil agus ó Mheánscoil San Nioclás a fágaint slán le máistreás poist na Rinne inniu. Labhair Sláine Ní Chathalláin le Fionn Mac Giolla Choda agus Breege Ui Mhurchú agus fearg orthu go raibh deireadh ré ag Oifig Poist na Rinne.
Jimmy Breathnach, Máire Breathnach, Nioclás Ó Gríoftáin, Deaglán Turaoín a léiriú a mí shástacht le dúnadh Oifig Poist na Rinne.
In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the potential therapeutic implications of SS-31 peptide not only on the cellular level in mitigating mitochondrial dysfunction, but also its role in various disease settings and exercise capacity as well. Topics: 1. Overview of Mitochondrial Structure - Outer membrane and inner membrane with cristae - Mitochondrial matrix containing DNA, ribosomes, and enzymes - Inner membrane with electron transport chain complexes (I to IV) and ATP synthase 2. Functions of Electron Transport Chain Complexes - Complex I (NADH Dehydrogenase) transferring electrons from NADH to ubiquinone - Complex II (Succinate Dehydrogenase) transferring electrons from FADH2 to coenzyme Q - Complex III (Cytochrome bc1 Complex) passing electrons to cytochrome c and pumping protons - Complex IV (Cytochrome c Oxidase) transferring electrons to oxygen to form water and pumping protons 3. Role of Electron Transfer in ATP Synthesis - Proton pumping by complexes I, III, and IV creating an electrochemical gradient - ATP synthase utilizing proton gradient to synthesize ATP from ADP and Pi 4. Generation and Effects of Reactive Oxygen Species (ROS) - Formation of ROS as byproducts of ATP production - Types of ROS and their damaging effects on cellular components 5. Causes of ROS Production and Mitochondrial Dysfunction - Electron leak leading to premature electron reactions with oxygen - Factors contributing to increased ROS production such as environmental toxins and diet --- Leela Quantum Tech --- 6. Importance of Lipid Composition in Mitochondrial Membrane - Phospholipids, particularly cardiolipin, in the inner mitochondrial membrane - Role of cardiolipin in maintaining membrane integrity and supporting respiration proteins 7. Impact of ROS and Lipid Peroxidation on Mitochondrial Function - ROS-induced lipid peroxidation affecting cardiolipin composition - Implications of cardiolipin peroxidation in diseases like metabolic dysfunction and insulin resistance 8. SS-31 Peptide Intro - Accumulation in the inner mitochondrial membrane - Dimethyltyrosine residue scavenging oxyradicals and inhibiting lipid peroxidation 9. Mechanisms of Action of SS-31 Peptide - Stabilization of lipid constructs in the inner mitochondrial membrane - Prevention of mitochondrial permeability transition pore (mPTP) opening - Reduction of mitochondrial ROS and prevention of mitochondrial swelling and cell death 10. Applications and Research Areas of SS-31 Peptide - Studies in neuroinflammation, neurodegeneration, diabetes, age-related diseases, kidney disease, and cardiac function - Potential as a therapeutic agent for diseases associated with mitochondrial dysfunction 11. Conclusion - Overview of SS-31 peptide's mechanisms and potential applications - Reminder to always consult licensed medical professionals. Thanks for tuning in! Leela Quantum Tech Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
To connect with Amelia please visit here https://www.ameliaadrian.com/ And on instagram https://www.instagram.com/itsameliaadrian/ If you are not yet a dōTERRA Customer wish to order the Oils or Supplements click this link to have a browse https://www.ameliaadrian.com/shop-doterra and/or reach out to Amelia for guidance. Amelias' Daily Supplement Routine On Waking - Balance on the soles of my feet to set me on my path. Bergamot on Ear Shen Men Morning Meditation. Here for how. Terrazyme and Mito2Max with morning tea or water. Meta PWR Advantage Collagen + NMN supplement before my first meal of the day. 9 types of Collagen + Resveratol and NAD -> shown to increase NADH in the body. Lunchtime Lifelong Vitality Foundational Supplements Terrazyme before my main meal. Oils in Epsom Salts for my bath (eg Cedarwood, Lavender, Marjoram, Vetiver) Serenity Oil in the Diffuser, on my pillow for bedtime. Bookend the day with Balance Blend on my feet for settling Extras as and when needed: Deep Blue Polyphenols Complex if I have any pain in my body from over exertion or if I have an injury from which I am recovering. Serenity Softgels one or two if I need extra seep support PB Assist if my gut needs an extra boost. Zengest Softgels if any nausea or tummy discomfort.
Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! Book An Intro Coaching Call with Chloe Porter Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Tá gnó feola 'Micilín Muc' a dúnadh san Earrach. Deir Séamus Mac Gearailt go bhfuil athrú tagtha air chúrsaí gnó,agus ana chuid dá gcustaiméirí ag eirí as a ngnótha féin. Deir sé go raibh gnó maith aige agus go mbeadh sé oiriúnach do dhaoine óga.
Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may Access the show notes, transcript, and comments here.
Today's episode discusses the ongoing conflict between Israel and Hamas, with insights into the spiritual dimensions and the generational divide of perspectives on this issue. We're exploring why PM Netanyahu has said he rejects a truce with Hamas, whether reform is possible, and the biblical analysis behind this. Take advantage of this prophetic perspective on this complex issue! Today's Sponsor Strong Cell is designed to replenish and give back to your cells. It's a daily liquid supplement formulated with three key nutrients your cells need to function properly - NADH, CoQ10 and Collagen. Everyday stressors deplete your cells of these three things, causing them to function less effectively. With their proprietary process, Strong Cell can help replenish and revitalize your health at the cellular level. BEGIN YOUR JOURNEY TO CELLULAR HEALTH TODAY by going to lancewallnau.com/strongcell
Today, I am sharing how I make my own NAD+ patches (saving hundreds of dollars and avoiding NAD+ solution storage degradation). I also share the science behind electrochemical cells and how specialized patches use electrical charge to drive NAD+ into the body. Topics: 1. Introduction - Addressing Unprofessional Individuals - Breaking Stereotypes and Self-Limiting Beliefs 2. Background: My NAD+ Patches - The High Cost of Commercial NAD+ Patches and IV Drips - Benefits of Transdermal NAD+ Delivery - NAD+ in Energy Metabolism - Role of NAD+ in Glycolysis - NAD+ Utilization in the Krebs Cycle - Accumulation of NADH and Implications - The Appeal of NAD+ Therapy for Energy Metabolism 3. Creating My Own NAD+ Patches - Sourcing High-Purity NAD+ Powder - Solubility of NAD+ in Water - Preparing NAD+ Solution - Use of Iontophoresis Patches for Transdermal Delivery - Introduction to Electrochemical Cells - Role of Anode and Cathode - Electron Flow and Ion Exchange - Applying the NAD+ Solution to Patches - NAD+ Patch Dosage Rate and Duration 4. Cost Comparison - Expenses for My NAD+ Patches - Comparing My Costs to Commercial Patch Kits - Importance of Working with a Licensed Physician Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological. Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals. Mr. Cash has an MS in physics from the University of Oklahoma. As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm. In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer.
In today's episode, we are diving into NAD+ and exploring how it is a critical component for breaking down fuel, such as glucose, and ultimately converting that fuel to ATP. We will explore various factors that deplete NAD+ or decrease the NAD+/NADH ratio as well as 6 proven strategies to increase NAD+ within the body. Lastly, we wrap up the episode with a conversation pertaining to the use of NAD+ therapy for CIRS/Biotoxin illness, specifically Mold Illness. Thanks so much for tuning it! Topics: 1. Understanding NAD+ and Its Role - Definition of NAD+ and NADH - Explanation of coenzymes in chemical reactions - NAD+ and NADH as coenzymes for electron transfer - Role in glucose metabolism and energy production - Importance of NAD+ for various cellular functions 2. Glycolysis and NAD+ - Illustration of glucose metabolism and insulin release - Role of GLUT4 transporters in glucose entry into cells - Introduction to glycolysis and its steps - Role of NAD+ as a coenzyme in glycolysis - Generation of NADH during glycolysis 3. TCA (Krebs) Cycle and NAD+ - Transition of pyruvate to acetyl-coA - Overview of the krebs cycle and its steps - NAD+ as a coenzyme in the krebs cycle - Accumulation of NADH during the cycle 4. Electron Transport Chain and NADH - Movement of pyruvate into the mitochondria - Role of NADH as an electron donor in the electron transport chain (ETC) - ATP production through the ETC 5. Factors Disrupting NAD+ Balance - Impact of toxins and pesticides on the ETC - Role of drugs, like NSAIDs, in inhibiting the ETC - Generation of reactive oxygen species (ROS) - Role of ROS in mitochondrial damage and NAD+ depletion - Link between NAD+ decline and aging 6. Consequences of NAD+ Depletion - Effect of NAD+ reduction on metabolism - Connection between NAD+ and metabolic diseases - Therapeutic potential of NAD+ in age-related diseases 7. 6 Strategies for NAD+ Restoration - Which supplemental NAD+ precursors are more effective - Inhibition of the CD38 enzyme using dietary nutrients - NAD+ IVs and patches: cost and quality - Intermittent fasting - Exercise and NAD+ - Other less well-known lifestyle factors that have a big impact on NAD+ 8. NAD+ Therapies to Support Recovery from Mold Illness - Link between NAD+ depletion and mold illness - Thoughts on and logic behind the use of NAD+ therapies for CIRS recovery Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Short Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with supplementation but does not decrease in deficiency. Plasma zinc is decreased by inflammation, oxidative stress, the ovulatory and luteal phases of the menstrual cycle, probably pregnancy and oral contraceptive use, and any kind of stress that leads to an adrenal output. If plasma zinc declines despite supplementation, corroborate that this reflects zinc status by showing normal hair zinc and low urine zinc. Use symptoms as the ultimate arbiter of whether zinc supplementation is helping. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Glutathione Intolerance: Getting to the Bottom of It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.
Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Josh Rabinowitz is a Professor of Chemistry and Integrative Genomics at Princeton University, where his research focuses on developing a quantitative, comprehensive understanding of cellular metabolism through the study of metabolites and their fluxes. In this episode, Josh focuses the discussion on three main topics: metabolomics, NAD (and its precursors), and cancer metabolism. The metabolomics discussion starts with a broad definition of metabolism, metabolites, and fluxomics before diving deep into glucose metabolism, lactate as a fuel, movement of lactate, and the regulation of these substrates. He then gives a detailed explanation of the electron transport chain and Krebs cycle and their implications with respect to both drugs and nutrition while also explaining how NAD is central to the process of energy generation. He then discusses the age-related decline in NAD and what current literature says about efforts to increase NAD through intravenous or oral supplementation with the precursors NMN and NR, including whether doing so provides any advantage to lifespan or healthspan. Finally, Josh ends the conversation talking about cancer metabolism and how one particular intersection between cancer metabolism and immunotherapy might provide a hopeful outlook on the future of cancer treatment. We discuss: Josh's background and unique path to becoming a research scientist at Princeton [3:30]; What sparked Josh's early interest in metabolism [11:15]; Metabolomics 101: defining metabolites and how they are regulated [16:30]; Fluxomics: metabolism as a system in action [26:00]; The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation [33:30]; The important role of lactate as an alternate fuel [36:30]; Fasting lactate levels as a potential early indicator of metabolic dysfunction [48:00]; The beauty of the Krebs cycle and the role of NAD in energy production [53:15]; How the drug metformin acts on complex I of the electron transport chain [1:05:00]; The difference between NADH and NADPH [1:08:45]; NAD levels with age, and the efficacy of supplementing with intravenous NAD [1:10:45]; The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN [1:22:15]; Exploring the hypothesis that boosting NAD levels is beneficial [1:32:30]; Cancer metabolism and the intersection with immunotherapy [1:39:00]; Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more [1:46:15]; The challenge of treating pancreatic cancer [1:50:30]; Epithelial cancers that might respond to metabolic approaches to therapy [1:56:30]; Josh's hopeful outlook on the future of cancer treatment [1:59:00]; Nutritional approaches to cancer attenuation [2:00:15]; What makes Princeton University special [2:06:15]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
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