Podcasts about nadh

Energie und Langlebigkeit in einem Molekül!?? Das klingt beinahe zu schön, um wahr zu sein. Hören sie in der aktuellen Folge der INUMED Sprechstunde ein Expertengespräch über einen körpereigenen Stoff, der beides vereint. Panmol® NADH, quasi das Ying und das Yang unseres Stoffwechsels. Worum es sich bei diesem Wunderwuzzi unter den Nährstoffen handelt, wo es vorkommt und wo der Haken an der ganzen Geschichte ist, wird ebenso erörtert, wie auch die Frage, wie dieser Haken zu lösen ist. Nämlich wieder einmal durch natürliche Pflanzenstoffe. Besonders gut zuhören sollten Menschen mit mentalen oder körperlichen Leistunsgschwächen, wie z.B. Chronic Fatigue und übermäßiger Ermüdbarkeit, Konzentrationsschwächen, Demenz, Depressionen, Leberschwäche, aber auch Sportler und Denkakrobaten, die Ihre Leistung verbessern möchten. Aber, mal ehrlich: Wer von uns hätte nicht gerne mehr Energie zur Verfügung?“ Zur Studie: https://www.inumed.com/files/pdf/240434_10-1055-a-2257-6314_Authors%20Offprint.pdf Rösler D, Fuchs N, Markolin G, Edler B, Sauer L, Studer M: Einfluss einer NADH-haltigen Nährstoffkombination auf Gedächtnis, Konzentration und Grundstimmung. OM & Ernährung 2008; 125: F20-F25 Zum Produkt: https://shop.nutribioticum.com/mangelausgleich/nadh_akg_creatin.html _ DAS MILIEU IST DER SCHLÜSSEL ZUR GESUNDHEIT _ www.INUMED.at www.NUTRIBIOTICUM.com _ Die Empfehlungen in diesem Podcast sind auf dem neuesten Stand der ernährungs- und sportmedizinischen Wissenschaft sie ersetzen jedoch im Krankheitsfall nicht die ärztliche Konsultation. Im Zweifelsfall konsultieren Sie bitte einen erfahrenen Ernährungs- oder Ganzheitsmediziner.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMEn este episodio Patri Psicóloga nos explica que pensar mucho no siempre equivale a pensar mejor, que la ansiedad tiene muchas caras y que ocuparnos de todo se paga con la salud física y mental. Si te gusta el episodio y quieres vernos en directo en el teatro, compra tus entradas en www.patripsicologa.com/teatroEn abril el mecenas es el complemento alimenticio NADH de HSN. Seguro que has oído hablar del NAD. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan un 65% entre los 30 y 70 años. Y eso se nota: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como dar un empujón a tu energía celular. Puede ayudar a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud. Llévate de regalo* una botella HSN de acero inoxidable en pedidos superiores a 79 euros. Usa el cupón CRISMITRE. *Regalo disponible hasta fin de existencias. No acumulableInstagram @thebeautymailTwitter @cristinamitreYouTube https://www.youtube.com/c/CristinaMitreLinkedIn Cristina Mitre ArandaFacebook https://www.facebook.com/CrismitreTrack: "Walk!", lov3rMusic provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/d64537c5-4d7f-4ac4-87b0-4bc2fd228abd?utm_source=attributionListen on Spotify: https://go-stream.link/sp-lov3rTrack: "Latin Party.-Instrwav"Music provided by https://slipstreammusic.comDownload / Stream: https://slipstreammusic.com/tracks/cb324323-0998-4319-a5c0-8c9380be5c33 Hosted on Acast. See acast.com/privacy for more information.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMComer sano no es hacer dietas extremas, ni pasar hambre, ni vivir sin pan toda la vida. Es aprender a elegir, organizarse y disfrutar de todos los grupos de alimentos sin miedo. ¿Y lo mejor? No tiene por qué ser caro. Nos lo va a contar Jessica Hierro en este episodio.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COM¿Es posible tener un problema con el alcohol sin darse cuenta? El alcohol forma parte de nuestra vida: nos reunimos en torno a él, lo asociamos con relax, descanso o fiesta. Pero esa normalización puede esconder una realidad compleja: la adicción al alcohol. Y no siempre tiene la forma que imaginamos. Bajo una apariencia “normal”, muchas personas sufren dependencia del alcohol. El Dr. Gabriel Rubio, jefe de Psiquiatría del hospital 12 de Octubre, especializado en tratamiento del alcoholismo, nos va a mostrar cómo se inicia la adicción al alcohol, cómo cambia con los años, qué impacto tiene en la persona y su familia, qué supone recuperarse o qué papel juegan la vergüenza y la culpaEn abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

Hey, welcome back! Today, we're diving into something that can seriously up your game when it comes to energy, performance, and even longevity—NAD+. If you haven't heard of it, don't worry, we've got you covered. We're also going to talk about some awesome peptide stacks that can keep you feeling energized and performing at your best—whether that's crushing it in your workouts or staying sharp through your workday grind. So, if you're looking to boost your fitness, stay more focused at work, or just feel more energized in general, this episode's for you. What is NAD+? Alright, let's kick things off with the basics—what is NAD+? It stands for Nicotinamide Adenine Dinucleotide, which is a bit of a mouthful, but it's actually a co-enzyme that's super important for energy production in your body. Think of it as the fuel for your cells. Without NAD+, your cells can't make energy, which is obviously a big deal. Now, here's the thing—our NAD+ levels drop as we get older. This can lead to feeling tired, slower recovery, and just a general lack of energy. But don't panic—there's good news! Supplementing with NAD+ (either through injections or IV infusions) or even helping your body boost its NAD+ production naturally can actually reverse some of these aging effects. Not only will you feel more energized, but you'll also get benefits like improved focus, better endurance, faster recovery, and even some anti-aging perks. How Does NAD+ Work? So, how does NAD+ actually work in the body? It plays a huge role in energy production by helping with mitochondrial respiration. Basically, it cycles between two forms—NAD+ and NADH—to help produce ATP, which is the energy currency of your cells. But that's not all. NAD+ also impacts proteins called sirtuins that regulate metabolism, stress responses, and longevity. It even activates enzymes like PARPs that help with DNA repair, which is key for maintaining cell integrity, especially when dealing with things like aging and stress. And on top of that, NAD+ is involved in cell signaling pathways that influence things like inflammation, insulin sensitivity (which could help with weight management), and even your circadian rhythm. What Are the Benefits of NAD+? So, you've got energy, anti-aging, and DNA repair—but that's just the start. NAD+ can also help with memory, focus, and mental clarity by keeping your neurons healthy and protected from neurodegeneration. In fact, there's some research showing that NAD+ therapy could even help with managing withdrawal symptoms and cravings, particularly for alcohol and opioid dependencies. Are There Any Side Effects of NAD+? Like anything, NAD+ therapy can have some side effects, though it's generally considered safe. Some people may experience things like low blood pressure, flushing, nausea, headaches, or fatigue, especially after an injection. But the good news is these side effects tend to go away on their own, and over time, your energy levels will start to improve. Let's Talk About Stacking NAD+ for Even More Benefits Okay, so you're probably wondering how to make the most of NAD+. Well, stacking it with the right supplements can seriously amplify its effects. But it's not just about throwing a bunch of stuff together and hoping for the best. You've got to have the right combos to really level up your energy, endurance, and focus. Here are my top four NAD+ stacks: NAD+ + Glutathione This stack is great for detoxing and reducing oxidative stress. It supports your cellular health and helps fight free radicals, which is key for feeling good and staying healthy long-term. NAD+ + 5 Amino-1MQ If you're looking to support metabolic health and fat loss, this one's for you. 5 Amino-1MQ is a peptide that works really well with NAD+ to boost fat-burning and improve metabolic efficiency. NAD+ + Thymosin Alpha-1 Thymosin Alpha-1 is a peptide that's all about boosting your immune system. When combined with NAD+, it enhances your immune-regulating effects, making it a powerful duo for longevity and immune resilience. NAD+ + Epitalon Epitalon is a peptide that helps with telomere health, which is essential for anti-aging. When paired with NAD+, it supports cellular repair and overall longevity. If you're thinking about adding NAD+ to your routine, I'd recommend starting with a high-quality supplement. Take it consistently, pair it with the right stacks, and give it a bit of time to work its magic. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey.  Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

What are the pros, cons, and efficacy of dihydronicotinamide riboside (reduced NR), perhaps the most potent NAD+ precursor, as well as reduced NMN, taking NAD+ directly, or making it from scratch from tryptophan?

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER Y RECIBE CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADONOTAS DEL EPISODIO: WWW.CRISTINAMITRE.COMHoy vamos a hablar de amor propio con todo un experto: Walter Riso. Si miras su web verás que trabaja desde hace treinta años como psicólogo clínico y formador de terapeutas, práctica que alterna con el ejercicio de la cátedra universitaria en Latinoamérica y España, y la publicación de textos científicos y de divulgación, en diversos medios. Ha publicado 30 libros, entre textos técnicos y de divulgación, que han sido traducidas a más de 20 idiomas. Hoy vamos a profundizar con él en los temas de su último libro, Los siete pilares del amor propio, cuya lectura es más que recomendable para mejorar la relación que tienes con la persona más importante de tu vida: TÚ.En abril tenemos de mecenas al complemento alimenticio NADH de HSN, un producto muy interesante. Seguro que has oído hablar del NAD, la molécula de moda en longevidad y salud. Está en todas nuestras células y es esencial para generar energía y reparar tejidos. Probablemente, te suene por la cosmética: la niacinamida es un precursor del NAD, es decir, ayuda al cuerpo a producirlo. El problema del NAD es que sus niveles bajan hasta un 65% entre los 30 y los 70 años. Y eso puede notarse: menos energía, más cansancio, y envejecimiento celular más acusado. El complemento alimenticio NADH de HSN es una forma activa y estable que el cuerpo puede usar directamente. Como darle un empujón a tu energía celular. Puede ayudarte a sentir más energía, cuidar tu concentración y proteger tus células frente al estrés oxidativo. Además, contiene Panmol®, patente exclusiva que garantiza un NADH estable y sin degradación, y vitaminas B3 y B5, esenciales en el metabolismo. Ya sabes que la base son los hábitos, pero un complemento alimenticio bien formulado puede ser una ayuda. Recuerda que antes de tomarlos es recomendable consultar con un profesional de la salud.

Story at-a-glance High blood sugar in Type 2 diabetes overwhelms cellular machinery like a chaotic factory, creating not just oxidative stress as previously thought, but also a more fundamental problem called reductive stress. Reductive stress occurs when there's an oversupply of electron-carrying molecules in cells, creating a "traffic jam" of electrons that can't be processed efficiently by the mitochondria's electron transport chain While traditional views focused on oxidative stress alone, scientists now understand that reductive stress actually triggers oxidative stress. It's the initial spark that sets off a chain reaction of cellular damage in diabetic conditions When the main pathway for processing glucose becomes blocked due to reductive stress, sugar molecules get diverted into harmful alternative pathways, creating additional toxic byproducts and inflammation The combination of reductive and oxidative stress explains many serious complications of diabetes including neuropathy, retinopathy, nephropathy, and cardiovascular problems — all stemming from this initial electron overload Understanding reductive stress offers new therapeutic possibilities. Instead of just focusing on lowering blood sugar or fighting oxidative damage after it occurs, effective treatments target the electron transport chain efficiency and/or help cells recycle NADH more effectively

Red blood cells are entirely dependent on glucose as their only energy source. Glucose is utilized in glycolysis to produce the ATP output required by the red blood cell because red blood cells lack mitochondria, which would metabolize pyruvate to CO2 in other cells. The glycolytic output of energy from glucose breaking down to two lactates will produce two ATPs only because the NADH produced from the glyceraldehyde 3-phosphate dehydrogenase step of glycolysis will be consumed in the conversion of two 2-pyruvates to two lactates. Check out the original short on glucose and red blood cells below: https://youtube.com/shorts/nbEF42DaAko?feature=share

Guest Kailash Nadh Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard Littauer sits down with Kailash Nath, CTO of Zerodha, to delve into the dynamics of funding and sustaining open-source projects. They explore the establishment of Zerodha's FLOSS/Fund, which allocates a million dollars annually to support pivotal open source projects and discuss the development of the funding.json format to streamline grant applications. The conversation also covers the challenges of creating such funds, including regulatory hurdles, and aims to make financial assistance globally accessible. From detailing efforts to revive India's open-source communities through the FOSS United Foundation to highlighting the obstacles and innovative models in funding open-source software, the episode provides a comprehensive look at both global and Indian perspectives. Hit download now! [00:01:14] Richard brings up the FLOSS/Fund, a $1 million annual commitment to open source projects. Kailash confirms that the fund is still active and explains how it recently became more structured and a small team has been formed to manage the logistics of the fund. [00:02:48] The FLOSS/Fund has been created to publicly commit to supporting open source in a structured way. Kailash points out that while other companies give donations to open source, there are few structured initiatives from large organizations. [00:04:33] Kailash expresses frustration that few billion-dollar companies have set up similar initiatives to support open source projects. [00:06:24] Kailash explains that the FLOSS/Fund is open to the global open source community and target systemically important projects like libraries and widely used software tools. [00:08:14] Richard inquires about the application process and Kailash explains instead of traditional grant forms, projects must create and publish a “funding.json” file. [00:10:35] Kailash shares that the structured application method is designed to avoid the usual awkwardness of fundraising conversations and streamline the process. [00:13:31] The two discuss the difficulty maintainers face when articulating the importance of their projects, particularly for maintainers who may not have strong written communication skills, Kailash emphasizes that the funding.json method does not replace narrative descriptions but simplifies signaling. [00:16:17] The conversation switches to global scope and prioritization as Kailash tells us Zerodha's open source contributions are not limited to projects they directly use, the fund is open to all global projects, and Zerodha hopes to support projects that are crucial for open source infrastructure. [00:17:09] Kailash discusses the complexity of sending money internationally from India. [00:18:59] We learn the goal is not to make funding.json go viral through financial incentives, but to organically grow adoption if the tool proves valuable. [00:20:49] Richard and Kailash explore the broader challenges of sustaining open source projects beyond funding, such as building healthy communities and incentivizing the proper use and citation of open source infrastructure. [00:25:32] Kailash discusses the Indian open source ecosystem. [00:30:29] Kailash explains how Zerodha's initiatives aim to push the Indian industry to give back more to the open source community. He hopes that their efforts will inspire other companies to set up similar initiatives. [00:32:12] Find out where you can donate to Floss fund and follow Kailash online. Spotlight [00:32:56] Richard's spotlight is his first grade teacher, Mrs. Barril. [00:33:25] Kailash's spotlight is Jim Martsolf who introduced him to “webmastering.” Links SustainOSS (https://sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) richard@sustainoss.org (mailto:richard@sustainoss.org) SustainOSS Discourse (https://discourse.sustainoss.org/) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Kailash Nadh LinkedIn (https://www.linkedin.com/in/kailashnadh/) Kailash Nadh Website (https://nadh.in/) Zerodha (https://zerodha.com/) funding.json (https://floss.fund/funding-manifest/) Sustain Podcast-Episode 153: Kailash Nadh and the FOSS United Foundation (https://podcast.sustainoss.org/153) FLOSS/Fund (https://floss.fund/) FFmpeg (https://ffmpeg.org/) Zig (https://ziglang.org/) Sustain Podcast-Episode 247: Chad Whitacre on the Open Source Pledge (https://podcast.sustainoss.org/247) Open Source Pledge (https://opensourcepledge.com/) Announcing FLOSS/fund: $1M per year for free and open source projects-post by Kailash Nadh (https://floss.fund/blog/announcing-floss-fund/) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Kailash Nadh.

Geburtstagsspecial: Insights zu Romans liebsten Produkten für mehr Energie und Wohlbefinden   Heute habe ich einen ganz besonderen Gast: meinen Mann Roman Gruber. Gemeinsam sprechen wir über sein exklusives Geburtstagsbundle, das einige seiner Lieblingsprodukte enthält. Im Fokus stehen der Faceformer, das Energy, das Colostrum Strong Flüssig und das Magnesiumtaurat. Roman erläutert, warum gerade diese Produkte zu seinen Favoriten gehören und welche Vorteile sie bieten. Zudem geben wir spannende Einblicke in die Anwendung und Wirkung dieser Produkte. Romans Lieblingsproduktebundle FACEFORMER - Ein innovatives Trainingsgerät, das die Nasenatmung und die Muskelentwicklung im Gesichtsbereich verbessert. Besonders hilfreich bei Schnarchen und Stressabbau ENERGY - Ideal für Menschen, die einen Energieboost benötigen oder an Migräne leiden. Enthält Q10 und NADH für die Unterstützung der Mitochondrien FLÜSSIGES COLOSTRUM - Ein unverzichtbares Notfallprodukt zur Stärkung des Immunsystems. Perfekt für akute Situationen wie Halsschmerzen oder Hautprobleme MAGNESIUMTAURAT - Eine besonders gut aufnehmbare Form von Magnesium, die auch nicht zu Durchfall führt, wie das bei anderen Magnesiumpräparaten der Fall sein kann LINKS Romans Lieblingsproduktebundle: https://shop.arktisbiopharma.ch/romans-lieblingsprodukte-bundle/B-014 Magnesiumtaurat: https://shop.arktisbiopharma.ch/mgt-magnesiumtaurat-kapseln/110380-6er Colostrum Strong: https://shop.arktisbiopharma.ch/colostrum-strong-125-ml/360000 Faceformer: https://shop.arktisbiopharma.ch/faceformer-zero/DI-FF-GPR-V Energy: https://shop.arktisbiopharma.ch/energy-q10-nadh-60-kps/100309-6er Energy im Fokus: Roman Gruber im Interview über das neue Produkt mit Q10 und NADH (DG229) - https://arktisbiopharma.ch/energy-im-fokus-roman-gruber-im-interview-ueber-das-neue-produkt-mit-q10-und-nadh-dg229/ Uwe Gröber über Magnesium und Magnesium-Taurat – Wichtige Erkenntnisse eines Mikronährstoffexperten (DG269) - https://arktisbiopharma.ch/uwe-groeber-ueber-magnesium-und-magnesium-taurat-wichtige-erkenntnisse-eines-mikronaehrstoffexperten-dg269/ Die Folgenotizen und eine schriftliche Zusammenfassung zu dieser Episode findest du unter: https://www.arktisbiopharma.ch/279   Als Podcasthörer:in bekommst du von uns einen Rabatt auf unsere Produkte. Und zwar 15% Rabatt auf deinen ersten Einkauf (1-mal anwendbar, nur auf nicht bereits rabattierte Produkte). Der Gutscheincode ist in beiden Arktis BioPharma Shops in der SCHWEIZ und in DEUTSCHLAND gültig.  Gib hierfür den Gutscheincode podcast15 ein, bevor du deine Bestellung abschliesst. https://shop.arktisbiopharma.ch https://arktisbiopharma.de/ Abonniere den Darmglück-Podcast in deiner Lieblings-Podcastapp (Apple Podcasts, Spotify, Deezer, Google Podcasts etc.), indem du “Darmglück” in die Suche eingibst.

Cara Nic Giolla Chomhaill ag labhairt linn faoi dhúnadh 6 Sráid Fhearchair ar feadh 3 bliana agus athchóiriú suntasach á dhéanamh ar an bhfoirgneamh.

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Website: https://t.me/dannyroddy   Danny's Substack: https://dannyroddy.substack.com/   Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson's Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson's Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson's Blueprint and how to measure health 32:39 – Bryan Johnson's supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall's response to our take on glucagon and insulin 1:24:17 – glucagon's short-term and long-term effects on metabolic function 1:26:46 – glucagon's role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health

In this episode, we delve into a revolutionary longevity molecule that you might not have heard of before: 1-MNA. If you're interested in staying younger longer and if you want to maintain your energy and vitality then this is an episode for you. Perhaps you have read the groundbreaking book by Dr David Sinclair "Lifespan" where he talks about NAD and how crucial it is for the body and how it can help upregulate sirtuin genes (longevity genes) and help you maintain your cellular health and energy. We are now 4 years on we have more data, studies and information to share in this arena. Perhaps you have been trying to improve  your NAD metabolism, taking NMN (nicotinamide mononucleotide)  or NR (nicotinamide riboside), and upregulating sirtuin genes, if you have then you need to hear this.  We'll explore the intricacies of NAD pathways, the role of key enzymes, and why simply supplementing with NAD precursors may not be the best holistic approach and how we can improve on that approach to anti-aging Key Points Discussed: Introduction to NAD Metabolism: Overview of previous episodes on NAD metabolism with experts like Professor Joseph Baur, Dr. Elizabeth Yurth from the Boulder Longevity Institute, and Dr. Elena Seranova. Importance of understanding the complexities of NAD pathways beyond the basics. Understanding 1-MNA: Explanation of 1-MNA and its role in controlling NAD levels by blocking the enzyme NNMT (Nicotinamide N-methyltransferase). The dangers of upregulating NNMT, which degrades NAD and can lead to various health issues. Key Enzymes in NAD Metabolism: Discussion on the salvage pathway and two critical enzymes that degrade NAD. Importance of regulating NNMT to prevent its deleterious effects, particularly in senescent cells, cancer cells, and fat cells. Benefits of 1-MNA How 1-MNA can help maintain a balanced NAD metabolism by inhibiting NNMT. Potential benefits for conditions like schizophrenia, neurodegeneration, liver diseases, and cancer. Research and Studies: Overview of studies showing the positive effects of 1-MNA on post-COVID conditions, inflammation, and mitochondrial function. Insights from animal studies on 1-MNA's protective effects against metabolic disorders. Practical Applications: Recommendations for integrating 1-MNA into supplement regimens, especially for those taking NMN or NR. Potential benefits for various conditions, including obesity, metabolic syndrome, cardiac disease, liver disease, cancer risk, long COVID, and fatigue. Balancing NAD Levels: Importance of maintaining NAD levels for energy production, DNA repair, neurotransmitter health, and longevity. The role of NAD as a redox molecule and the balance between NAD+ and NADH. Conclusion: Encouragement to explore further research on NNMT and its impact on health. Final thoughts on the potential of 1-MNAas a crucial supplement for maintaining NAD balance and promoting longevity. References and Links: Boulder Longevity Institute: https://boulderlongevity.com/ SSRP Institute: https://ssrpinstitute.org/ Studies on NNMT and related conditions: Research   If you enjoyed this episode, please give it a like, share, and subscribe to the YouTube channel. Tune in weekly for more interviews with top doctors and scientists on health optimization and longevity. Get Your 1-MNA now If you want to start supplementing with 1-MNA to support your own healthy aging journey, to upregulate your NAD metabolism, support sirtuin genes and prevent the overexpression of the deleterious NNMT Enzyme you can buy it here: 1-MNA and use code NAD to get $25 off your first order Stay up-to-date with the latest research and evolve with the science to optimize your health and longevity. See you in the next episode!       Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

KAPELA_FM: Basy z basy je nový kolaboratívny projekt Breathe the vapor (Lukáš Klinec) a St. Emmita (Emma Stašáková)

The world of detox supplementation, debunking common misconceptions and highlighting its crucial role in maintaining optimal health. Detox supplements are explained as essential providers of nutrients necessary for the body's detoxification processes, rather than direct detoxifiers. Using relatable analogies like baking a cake, the discussion emphasizes the importance of addressing nutritional deficiencies to support natural detox pathways. The video also explores the impact of reduced nutrient values in food and increased exposure to environmental toxins, which elevate the need for proper supplementation.The dangers of neglecting detox supplementation, especially when using potent substances like semaglutide and other anabolic agents, are highlighted. Balancing supplement intake to support organ function during detoxification and boost levels of vital compounds like glutathione and NADH is underscored. Rooted in chiropractic and natural health principles, the video advocates for a holistic approach to health, where providing the body with necessary chemicals allows it to perform its natural detoxification processes effectively. This comprehensive guide underscores the significance of detox supplements in supporting overall well-being.Highlights of the Podcast00:05 - Introduction to Detox Supplementation00:30 - Misconceptions About Detox Supplements01:10 - Role of Nutrients in Detoxification01:37 - Analogy for Understanding Nutrient Deficiency02:30 - Decreasing Nutrient Values in Food03:19 - Increased Toxic Load and Stress04:10 - Function of Detox Supplements04:43 - Impact of Supplements on Pathogens05:00 - Balancing Supplement Intake06:10 - Danger of Ignoring Detox Supplements08:11 - Role of Glutathione in Detoxification09:00 - NADH and Its Functions09:36 - Philosophy of Detoxification10:30 - Counterargument to Detox Supplement Skepticism11:15 - Conclusion and Call for Questions

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

In this episode of The Metabolic Classroom, Dr. Bikman introduces the concept of the Randle Cycle, also known as the glucose fatty acid cycle, in a lecture aimed at providing a better understanding of metabolism. The Randle Cycle, first identified by Dr. Philip Randle and his colleagues in the 1960s, explores how cells decide between using glucose or fatty acids for fuel. Dr. Bikman emphasized that this cycle has been misinterpreted on social media and aims to clarify its relevance in metabolic functions and nutritional decisions.https://www.insuliniq.com 00:00 - Introduction to the Metabolic Classroom and Dr. Ben Bikman01:00 - Overview of the Randle Cycle (Glucose Fatty Acid Cycle)02:00 - Historical Background: Philip Randle's Research03:00 - Experimental Model: Perfused Rat Hearts04:00 - Key Terms: Glucose and Fatty Acids05:00 - Concept of Substrate Competition06:00 - Reciprocal Inhibition: Fats vs. Glucose08:00 - Fatty Acid Oxidation Process10:00 - Biochemical Pathways: Acetyl-CoA, NADH, and Pyruvate Dehydrogenase12:00 - Role of Citrate in Glycolysis Inhibition14:00 - Glucose Utilization and Malonyl-CoA16:00 - Insulin's Role in Fuel Selection18:00 - Insulin's Impact on Glucose and Fat Burning20:00 - Diabetes Case Study: Type 1 and Type 222:00 - Type 1 Diabetes: High Glucose and Fatty Acids24:00 - Ketones Production in the Liver26:00 - Type 2 Diabetes: Insulin Resistance and Metabolic Inflexibility28:00 - Insulin Resistance in Fat Cells30:00 - Metabolic Inflexibility in Type 2 Diabetes32:00 - Insulin Resistance in the Brain34:00 - The Impact on Hunger and Neurological Disorders36:00 - Conclusion: Importance of Insulin in Metabolic Health#Metabolism #RandleCycle #DrBenBikman #InsulinResistance #GlucoseMetabolism #FattyAcidOxidation #MetabolicHealth #DiabetesResearch #Ketosis #Type1Diabetes #Type2Diabetes #InsulinRole #CellBiology #NutritionalScience #MetabolicFlexibility #Ketones #GlucoseUtilization #FatBurning #BiomedicalScience #HealthLectureMy favorite meal-replacement shake: https://gethlth.com (discount: BEN10)My favorite electrolytes (and more): https://redmond.life (discount: BEN15)My favorite allulose source: https://rxsugar.com (discount: BEN20)References:https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/randle-cycle Insulin Regulation of Ketone Body Metabolism: https://onlinelibrary.wiley.com/doi/10.1002/0470862092.d0308The Effects of a Ketogenic Diet and Exercise Interventions on Cognitive Function: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.31.1_supplement.lb810(Due to character length constraints, not every reference is posted above. For a complete list, please email: support@insuliniq.com with your request.) Hosted on Acast. See acast.com/privacy for more information.

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Debjyoti Kundu at Indiana Biosciences Research Institute's as he shares his poster titled "Pivotal role of NADH:ubiquinone oxidoreductase assembly factor 8 in beta cell stress adaptation".

Tá bácús Harrington sa Neidín ag eirí as an ngnó. Deireadh ré don mbácús neamhspleach a bhí soláthar aráin sa chontae ó 1995

Episode 31: Biochem of Sports Nutrition | Cauliflower Taco Meat Welcome to the Diet NPO Podcast! Your pod for RD Exam and nutrition questions. Come listen this week as we discuss Biochemistry of Sports Nutrition combined with practice questions and some Cauliflower Taco Meat! 1. If an athlete is training and develops a higher VO2 max, they would be relying more on which of the following processes? A. Anaerobic Glycolysis B. Lactic Acid Cycle  C. Creatine-Phosphate Pathway  D. Aerobic Glycolysis 2. Under anaerobic conditions, pyruvate can be converted into ______ through the Cori Cycle and can then be converted to ______ through gluconeogenesis. :  A. Lactate, Acetyl CoA B. Acetyl CoA, Glucose C. Lactate, Glucose D. Acetyl CoA, NADH 3. The pathway of aerobic metabolism that is producing the most amount of ATP through NADH and FADH intermediates, is known as the ________. A. Kreb's Cycle B. Citric Acid Cycle C. Aerobic Glycolysis D. Electron Transport Chain DM for your RD Exam tutoring needs! Instagram: @zak_snacks Threads: @zak_snacks Youtube: Zak Kaesberg MS, RDN

https://passionstruck.com/passion-struck-book/—Order a copy of my new book, "Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life," today! The book was picked by the Next Big Idea Club as a must-read for 2024, the winner of the Business Business Minds Best Book 2024, and shortlisted for the Eric Hoffer First Grand Prize.In this episode of Passion Struck, host John R. Miles interviews Oz Garcia, a trailblazer in nutritional science and healthy aging. Oz shares insights on the impact of nutrition on health, the importance of lifestyle choices, and the role of intermittent fasting in optimizing health and longevity. Oz emphasizes the significance of probiotics, prebiotics, and postbiotics for gut health and the benefits of supplements like NADH for energy and acetyl L-carnitine for brain function.Full show notes and resources can be found here:  https://passionstruck.com/dr-oz-garcia-on-the-secrets-to-a-healthier-life/In this episode, you will learn: The Power of Intermittent Fasting: Insights from Oz GarciaUnraveling the Secrets to a Healthier Life with Oz GarciaUnderstanding the Importance of Sleep with Oz GarciaProbiotics, Prebiotics, and Postbiotics: Oz Garcia's Guide to Gut HealthNADH and Acetyl Carnitine: Oz Garcia's Energy-Boosting SupplementsBrain Health Essentials: Acetyl L-Carnitine and Alpha-GPC with Oz GarciaMagnesium for Better Sleep and Nutrient Absorption: Oz Garcia's RecommendationsAll things Oz Garcia: https://ozgarcia.com/SponsorsBrought to you by Indeed. Head to https://www.indeed.com/passionstruck, where you can receive a $75 credit to attract, interview, and hire in one place.Brought to you by Nom Nom: Go Right Now for 50% off your no-risk two week trial at https://trynom.com/passionstruck.Brought to you by Cozy Earth. Cozy Earth provided an exclusive offer for my listeners. 35% off site-wide when you use the code “PASSIONSTRUCK” at https://cozyearth.com/This episode is brought to you by BetterHelp. Give online therapy a try at https://www.betterhelp.com/PASSIONSTRUCK, and get on your way to being your best self.This episode is brought to you By Constant Contact:  Helping the Small Stand Tall. Just go to Constant Contact dot com right now. So get going, and start GROWING your business today with a free trial at Constant Contact dot com.--► For information about advertisers and promo codes, go to:https://passionstruck.com/deals/Catch More of Passion StruckWatch my interview with Dr. Anthony Youn On How To Feel Great And Look Your BestCan't miss my solo episode on The Reverse Aging Effect: How To Stay Young And HealthyListen to my episode with Dr. Kara Fitzgerald On How To Become A Younger You By Reversing Your Biological AgeMy solo episode on The Science Of Healthy HabitsCan't miss my episode with Dr. Mark Hyman On How Personalized Medicine Is Revolutionizing HealthcareLike this show? Please leave us a review here-- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally!How to Connect with JohnConnect with John on Twitter at @John_RMiles and on Instagram at @john_R_Miles.Subscribe to our main YouTube Channel Here: https://www.youtube.com/c/JohnRMilesSubscribe to our YouTube Clips Channel: https://www.youtube.com/@passionstruckclips

Ceoltóirí ó bhunscoil agus ó Mheánscoil San Nioclás a fágaint slán le máistreás poist na Rinne inniu. Labhair Sláine Ní Chathalláin le Fionn Mac Giolla Choda agus Breege Ui Mhurchú agus fearg orthu go raibh deireadh ré ag Oifig Poist na Rinne.

Jimmy Breathnach, Máire Breathnach, Nioclás Ó Gríoftáin, Deaglán Turaoín a léiriú a mí shástacht le dúnadh Oifig Poist na Rinne.

In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the potential therapeutic implications of SS-31 peptide not only on the cellular level in mitigating mitochondrial dysfunction, but also its role in various disease settings and exercise capacity as well. Topics: 1. Overview of Mitochondrial Structure - Outer membrane and inner membrane with cristae - Mitochondrial matrix containing DNA, ribosomes, and enzymes - Inner membrane with electron transport chain complexes (I to IV) and ATP synthase 2. Functions of Electron Transport Chain Complexes - Complex I (NADH Dehydrogenase) transferring electrons from NADH to ubiquinone - Complex II (Succinate Dehydrogenase) transferring electrons from FADH2 to coenzyme Q - Complex III (Cytochrome bc1 Complex) passing electrons to cytochrome c and pumping protons - Complex IV (Cytochrome c Oxidase) transferring electrons to oxygen to form water and pumping protons 3. Role of Electron Transfer in ATP Synthesis - Proton pumping by complexes I, III, and IV creating an electrochemical gradient - ATP synthase utilizing proton gradient to synthesize ATP from ADP and Pi 4. Generation and Effects of Reactive Oxygen Species (ROS) - Formation of ROS as byproducts of ATP production - Types of ROS and their damaging effects on cellular components 5. Causes of ROS Production and Mitochondrial Dysfunction - Electron leak leading to premature electron reactions with oxygen - Factors contributing to increased ROS production such as environmental toxins and diet --- Leela Quantum Tech --- 6. Importance of Lipid Composition in Mitochondrial Membrane - Phospholipids, particularly cardiolipin, in the inner mitochondrial membrane - Role of cardiolipin in maintaining membrane integrity and supporting respiration proteins 7. Impact of ROS and Lipid Peroxidation on Mitochondrial Function - ROS-induced lipid peroxidation affecting cardiolipin composition - Implications of cardiolipin peroxidation in diseases like metabolic dysfunction and insulin resistance 8. SS-31 Peptide Intro - Accumulation in the inner mitochondrial membrane - Dimethyltyrosine residue scavenging oxyradicals and inhibiting lipid peroxidation 9. Mechanisms of Action of SS-31 Peptide - Stabilization of lipid constructs in the inner mitochondrial membrane - Prevention of mitochondrial permeability transition pore (mPTP) opening - Reduction of mitochondrial ROS and prevention of mitochondrial swelling and cell death 10. Applications and Research Areas of SS-31 Peptide - Studies in neuroinflammation, neurodegeneration, diabetes, age-related diseases, kidney disease, and cardiac function - Potential as a therapeutic agent for diseases associated with mitochondrial dysfunction 11. Conclusion - Overview of SS-31 peptide's mechanisms and potential applications - Reminder to always consult licensed medical professionals. Thanks for tuning in! Leela Quantum Tech Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

To connect with Amelia please visit here https://www.ameliaadrian.com/ And on instagram https://www.instagram.com/itsameliaadrian/ If you are not yet a dōTERRA Customer wish to order the Oils or Supplements click this link to have a browse https://www.ameliaadrian.com/shop-doterra and/or reach out to Amelia for guidance. Amelias' Daily Supplement Routine On Waking - Balance on the soles of my feet to set me on my path. Bergamot on Ear Shen Men Morning Meditation. Here for how. Terrazyme and Mito2Max with morning tea or water. Meta PWR Advantage Collagen + NMN supplement before my first meal of the day. 9 types of Collagen + Resveratol and NAD -> shown to increase NADH in the body. Lunchtime Lifelong Vitality Foundational Supplements 
 Terrazyme before my main meal. Oils in Epsom Salts for my bath (eg Cedarwood, Lavender, Marjoram, Vetiver) Serenity Oil in the Diffuser, on my pillow for bedtime. Bookend the day with Balance Blend on my feet for settling Extras as and when needed: Deep Blue Polyphenols Complex if I have any pain in my body from over exertion or if I have an injury from which I am recovering. Serenity Softgels one or two if I need extra seep support PB Assist if my gut needs an extra boost. Zengest Softgels if any nausea or tummy discomfort.

Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! ⁠⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠⁠ Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok ⁠⁠⁠⁠⁠@chloe_c_porter⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode of the Be Happy, Healthy and Wealthy podcast with Dr. Irene Ching, the focus is on post-COVID syndrome, also known as long COVID. Dr. Ching discusses the various mechanisms and causes of this syndrome, including long-term tissue damage, unresolved inflammation, and gut dysbiosis. She highlights the signs and symptoms of post-COVID syndrome, which range from fatigue and cough to cognitive impairment and heart issues. Dr. Ching then delves into the treatment plan, providing insights on gut health tests, adrenal salivary testing, and the use of supplements such as melatonin, vitamin D, low dose naltrexone, and glutathione. She also emphasizes the importance of addressing mitochondrial dysfunction and maintaining a healthy gut microbiota. Overall, this episode offers valuable information and tips for managing post-COVID syndrome. KEY TAKEAWAYS Post-COVID syndrome, also known as long COVID, can result in a variety of symptoms including fatigue, cough, breathlessness, cognitive impairment, depression, anxiety, and more. The causes of post-COVID syndrome include long-term tissue damage, unresolved inflammation, and gut dysbiosis. Treatment for post-COVID syndrome may involve addressing gut health, adrenal function, thyroid studies, melatonin levels, vitamin D levels, and using supplements such as low dose naltrexone, iodine nasal spray, and antioxidants like zinc, B vitamins, quercetin, and glutathione. Melatonin, in addition to its role in sleep regulation, has immune-boosting, anti-inflammatory, and antioxidant properties that can help in the treatment of COVID-19 and reduce cytokine storm. Mitochondrial dysfunction, which affects energy production in the body, can contribute to post-COVID symptoms. Supplements such as magnesium, coenzyme Q10, alpha-lipoic acid, D-ribose, NADH, and L-carnitine can help improve mitochondrial health. BEST MOMENTS"So some people are saying, oh what can we do, I'm tired all the time, I want treatment." "Melatonin aids the immune system, acts as an antioxidant, and blocks estrogen from binding to receptor sites." "Vitamin D is the king. It modulates the immune system, protects against endothelial dysfunction and clots, and improves outcomes in COVID-19." "Low dose naltrexone is anti-inflammatory and protective. It helps in hyper-inflammatory states like COVID-19." "Glutathione is the strongest antioxidant produced by the body. It helps reduce damage caused by SARS-CoV-2 and oxidative damage in the body."  VALUABLE RESOURCESJoin Patreon : http://www.patreon.com/drirenechingInstagram: irene.ching.777Tiktok: @ireneching777Youtube channel: Dr Irene ChingTwitter: @ireneching7777Clubhouse: @ireneching1 https://www.facebook.com/irene.ching.735LinkedIn : https://www.linkedin.com/in/irene-ching-742623219 HOST BIODr Irene Ching is a medical practitioner who specialises in Family Medicine, Wealth and Life Coach, Property/ Business Investor, Speaker, and Podcaster : Be Happy, Healthy and Wealthy. Dr Ching speaks on health, wellness and wealth in talks, workshops and events. She has her own coaching programme on money mindset - Quantum Wealth Creation Accelerator (online course with weekly coaching). She approaches health and well-being in a holistic way and encourages people to look at all the areas of their lives. In her coaching sessions, she works with emotional freedom techniques, energy works, NLP, Intuition/ Superconscious mind, Inner child healing, Timeline therapy, Self love works, behavioural change, goal settings and money attraction healing. Her motto: Reset Your Mind, Reset Your life. The podcast Be Happy Healthy and Wealthy is aimed at people who wants to be high achievers who perform at their peak performance in all aspects of life. It is about how we could be happy regardless of our circumstances, and to understand the secrets to real health and wealth; especially how to live a prosperous long life. She has been interviewing successful entrepreneurs, keynote speakers, influencers and millionaires on this important subject. So stay tuned to get the deep dive on how to be happy, healthy and wealthy- the million dollar questions!

Bist du oft müde und erschöpft? Dann könnte unser neues Produkt “Energy” interessant für dich sein Mein heutiger Interviewgast ist mein Mann, Roman. Wir sprechen über unser neues Produkt Energy.  Roman Gruber ist der Mitgründer und CEO von Arktis BioPharma Schweiz. Sein Background ist im Bereich Orthomolekulare Therapie, Biochemie, Darmgesundheit, Gesundheits-Coaching und Profi-Sport. In dieser Folge spricht Roman über die Beweggründe, dieses Produkt ins Sortiment zu nehmen. Energy ist eine Kombination von Coenzym Q10 und NADH. Wir sprechen über die Vorteile von Q10 und NADH, wer davon profitieren könnte und was man sonst noch beachten darf, wenn man oft müde ist oder der Stoffwechsel nicht genügend Energie produziert. Am Ende des Gesprächs gibt uns Roman einen Ausblick, welche neuen Produkte Arktis BioPharma demnächst auf den Markt bringen wird. Folgende Fragen habe ich Roman gestellt:

Tá gnó feola 'Micilín Muc' a dúnadh san Earrach. Deir Séamus Mac Gearailt go bhfuil athrú tagtha air chúrsaí gnó,agus ana chuid dá gcustaiméirí ag eirí as a ngnótha féin. Deir sé go raibh gnó maith aige agus go mbeadh sé oiriúnach do dhaoine óga.

"Už môj starý otec hovori, že sa nikdy nemám hádať s idiotmi, pretože to je ich ihrisko." Ľudovít Ódor je ekonóm. Päť mesiacov bol premiérom úradníckej vlády. Predtým pôsobil ako viceguvernér Národnej banky Slovenska. Je autorom niekoľkých kníh, tá najnovšia sa volá "Rýchlokurz geniality" a napísal ju pre svoju dcéru.

Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism.  This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may  Access the show notes, transcript, and comments here.  

Today's episode discusses the ongoing conflict between Israel and Hamas, with insights into the spiritual dimensions and the generational divide of perspectives on this issue. We're exploring why PM Netanyahu has said he rejects a truce with Hamas, whether reform is possible, and the biblical analysis behind this. Take advantage of this prophetic perspective on this complex issue! Today's Sponsor Strong Cell is designed to replenish and give back to your cells. It's a daily liquid supplement formulated with three key nutrients your cells need to function properly - NADH, CoQ10 and Collagen. Everyday stressors deplete your cells of these three things, causing them to function less effectively. With their proprietary process, Strong Cell can help replenish and revitalize your health at the cellular level. BEGIN YOUR JOURNEY TO CELLULAR HEALTH TODAY by going to lancewallnau.com/strongcell

Es gibt mittlerweile viele Anbieter von Darmgesundheitsprodukten, probiotischen und präbiotischen Produkten. Was zeichnet uns - Arktis BioPharma Schweiz -  aus? Punkte aus dieser Folge:

Today, I am sharing how I make my own NAD+ patches (saving hundreds of dollars and avoiding NAD+ solution storage degradation). I also share the science behind electrochemical cells and how specialized patches use electrical charge to drive NAD+ into the body. Topics: 1. Introduction - Addressing Unprofessional Individuals - Breaking Stereotypes and Self-Limiting Beliefs 2. Background: My NAD+ Patches - The High Cost of Commercial NAD+ Patches and IV Drips - Benefits of Transdermal NAD+ Delivery - NAD+ in Energy Metabolism - Role of NAD+ in Glycolysis - NAD+ Utilization in the Krebs Cycle - Accumulation of NADH and Implications - The Appeal of NAD+ Therapy for Energy Metabolism 3. Creating My Own NAD+ Patches - Sourcing High-Purity NAD+ Powder - Solubility of NAD+ in Water - Preparing NAD+ Solution - Use of Iontophoresis Patches for Transdermal Delivery - Introduction to Electrochemical Cells - Role of Anode and Cathode - Electron Flow and Ion Exchange - Applying the NAD+ Solution to Patches - NAD+ Patch Dosage Rate and Duration 4. Cost Comparison - Expenses for My NAD+ Patches - Comparing My Costs to Commercial Patch Kits - Importance of Working with a Licensed Physician Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological.  Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com  Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals.  Mr. Cash has an MS in physics from the University of Oklahoma.  As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business,  Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm.   In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer. 

In today's episode, we are diving into NAD+ and exploring how it is a critical component for breaking down fuel, such as glucose, and ultimately converting that fuel to ATP. We will explore various factors that deplete NAD+ or decrease the NAD+/NADH ratio as well as 6 proven strategies to increase NAD+ within the body. Lastly, we wrap up the episode with a conversation pertaining to the use of NAD+ therapy for CIRS/Biotoxin illness, specifically Mold Illness. Thanks so much for tuning it! Topics: 1. Understanding NAD+ and Its Role - Definition of NAD+ and NADH - Explanation of coenzymes in chemical reactions - NAD+ and NADH as coenzymes for electron transfer - Role in glucose metabolism and energy production - Importance of NAD+ for various cellular functions 2. Glycolysis and NAD+ - Illustration of glucose metabolism and insulin release - Role of GLUT4 transporters in glucose entry into cells - Introduction to glycolysis and its steps - Role of NAD+ as a coenzyme in glycolysis - Generation of NADH during glycolysis 3. TCA (Krebs) Cycle and NAD+ - Transition of pyruvate to acetyl-coA - Overview of the krebs cycle and its steps - NAD+ as a coenzyme in the krebs cycle - Accumulation of NADH during the cycle 4. Electron Transport Chain and NADH - Movement of pyruvate into the mitochondria - Role of NADH as an electron donor in the electron transport chain (ETC) - ATP production through the ETC 5. Factors Disrupting NAD+ Balance - Impact of toxins and pesticides on the ETC - Role of drugs, like NSAIDs, in inhibiting the ETC - Generation of reactive oxygen species (ROS) - Role of ROS in mitochondrial damage and NAD+ depletion - Link between NAD+ decline and aging 6. Consequences of NAD+ Depletion - Effect of NAD+ reduction on metabolism - Connection between NAD+ and metabolic diseases - Therapeutic potential of NAD+ in age-related diseases 7. 6 Strategies for NAD+ Restoration - Which supplemental NAD+ precursors are more effective - Inhibition of the CD38 enzyme using dietary nutrients - NAD+ IVs and patches: cost and quality - Intermittent fasting - Exercise and NAD+ - Other less well-known lifestyle factors that have a big impact on NAD+ 8. NAD+ Therapies to Support Recovery from Mold Illness - Link between NAD+ depletion and mold illness - Thoughts on and logic behind the use of NAD+ therapies for CIRS recovery Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Tá gnó gruagaireachta Bhaile Mhúirne a dúnadh an deireadh seachtaine seo. Braithfidh muintir na h-áite uatha go mór iad.

Muiríde Uí Chruadhlaoich, Paidí Ó Sé, Síle Uí Mhaolchatha; An tábhacht atá baint le siopa an Phobail fén dtuath.

The electron transport chain is a critical process in cellular respiration, facilitating the transfer of electrons from NADH and FADH2 to oxygen, leading to the production of ATP. NADH and FADH2 donate their electrons to the ETC, which consists of several protein complexes embedded in the inner mitochondrial membrane. These complexes, along with mobile electron carriers like CoQ10 and cytochrome c, facilitate the stepwise transfer of electrons, generating a proton gradient and ultimately driving ATP synthesis. Oxygen serves as the final electron acceptor, ensuring the continued flow of electrons and the efficient functioning of cellular respiration. --- Support this podcast: https://podcasters.spotify.com/pod/show/healthfacts/support

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, “Targeting cellular respiration as a therapeutic strategy in glioblastoma.” While glycolysis is abundant in malignancies, mitochondrial metabolism is significant as well. Mitochondria harbor the enzymes relevant for cellular respiration, which is a critical pathway for both regeneration of reduction equivalents and energy production in the form of ATP. In this research perspective, researchers Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, and Markus D. Siegelin from Columbia University Medical Center, City University of New York and Ulm University Medical Center discuss their recent finding that FDA-approved HDAC-inhibitors may have a profound impact on energy metabolism in solid tumor cells, including glioblastoma (GBM). “Because of the impact of HDAC-inhibitors on metabolism we hypothesized that imipridones, which suppress cellular respiration, might synergize with these compounds to significantly enhance killing of GBM cells [38]. Indeed, we found that imipridones reversed HDAC-inhibitor induced activation of cellular respiration and in turn the combination treatment facilitated induction of intrinsic apoptosis in a manner that was partially reliant on the anti-apoptotic Bcl-2 family members.” The oxidation of NADH2 and FADH2 are fundamental since NAD and FAD are the key components of the TCA-cycle that is critical to entertain biosynthesis in cancer cells. The TCA-cycle itself is predominantly fueled through carbons from glucose, glutamine, fatty acids and lactate. Targeting mitochondrial energy metabolism appears feasible through several drug compounds that activate the CLPP protein or interfere with NADH-dehydrogenase, pyruvate-dehydrogenase, enzymes of the TCA-cycle and mitochondrial matrix chaperones. While these compounds have demonstrated anti-cancer effects in vivo, recent research suggests which patients most likely benefit from such treatments. “In summary, targeting tumor cell metabolism is relevant and future research needs to identify patient populations that particularly benefit from such treatments. Moreover, while most studies related to metabolism still rest predominantly on the tumor cells it is critical to extend such observations to the microenvironment of the tumors, especially with regards to the immune system [41, 42].” DOI - https://doi.org/10.18632/oncotarget.28424 Correspondence to - Markus D. Siegelin - ms4169@cumc.columbia.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28424 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - glioblastoma, metabolism, lactate, carbon tracing, central carbon metabolism About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Short Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with supplementation but does not decrease in deficiency. Plasma zinc is decreased by inflammation, oxidative stress, the ovulatory and luteal phases of the menstrual cycle, probably pregnancy and oral contraceptive use, and any kind of stress that leads to an adrenal output. If plasma zinc declines despite supplementation, corroborate that this reflects zinc status by showing normal hair zinc and low urine zinc. Use symptoms as the ultimate arbiter of whether zinc supplementation is helping. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Glutathione Intolerance: Getting to the Bottom of It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october  Access the show notes, transcript, and comments here.

Guest Kailash Nadh Panelists Richard Littauer | Justin Dorfman Show Notes Hello and welcome to Sustain! The podcast where we talk about sustaining open source for the long haul. We're super excited to have as our guest today, Kailash Nadh. In 2020, he co-founded the FOSS United Foundation, a non-profit organization that supports the FOSS ecosystem in India, where he serves as director. He also has been the CTO of Zerodha, India's largest stock broking firm for the last decade. Today, our conversations with Kailash will take through the FOSS program at Zerodha, and he'll explain how they've grown to be one of the largest financial tech companies in India. He'll take us through the journey of starting the FOSS Foundation, Zerodha's funding for FOSS, and Kailash explains why people getting interested in open source is such a huge valuable concept and philosophy. Download this episode now to learn more! [00:02:20] Kailash tells us about the FOSS program at Zerodha and being a CTO. [00:06:46] There's a FOSS Pledge on the FOSS United website and Kailash explains who it's for and if anyone can sign it. [00:08:04] We learn about Zerodha's yearly budget to the FOSS Foundation. [00:10:36] A question comes up if there are any documents or resources Kailash has in place to help ensure that their interests at Zerodha don't erode away the native interests of any open source project. [00:13:04] Kailash tells us about paperd.ink. [00:15:04] Justin is curious to know if every part of the product is open source or if there's some type of proprietary in there and what their focus is for the funds. [00:16:01] Dwayne O'Brien's name comes up with the FOSS Contributor Fund, and if Kailash has ever talked to him. [00:17:32] Since it's hard to find people to fund right now, Richard wonders what the intake process is for Kailash to get new contributors and maintainers. [00:18:26] Does Zerodha have Community Managers or social media people to help out the foundation? [00:20:27] We hear about the different conferences in India. [00:23:58] Kailash explains what the people were interested in hearing about at the FOSS focused events and how enticing it is for people to go to them. [00:28:41] We hear Kailash's views on what he thinks about people getting interested in open source, and he tells us about the social development sector. [00:34:23] A questions comes up if there are any resources people could reach out to if they are in the NGO sector, or social sector. where they can learn what FOSS tools are best for them. [00:36:15] Find out where you can follow Kailash and his work online. Quotes [00:04:00] “We have close to zero SaaS subscriptions even as a really large enterprise.” [00:04:20] “FOSS really is why Zerodha exists today in the form it does.” [00:04:31] “We've grown to be one of the largest financial tech companies in India all on the back of FOSS.” [00:06:32] “Building everything community first, first principles, is really key.” [00:08:50] “At Zerodha, we've set aside one million dollars a year minimum to fund FOSS.” [00:20:29] “The conference a few months ago was IndiaFOSS, then a conference that happened in Kochi they named KochiFOSS, then DelhiFOSS, and there's an upcoming one MumbaiFOSS, which has a nice ring to it. This evolved organically with people in Kochi because they really wanted to call it KochiFOSS to identify with the city.” [00:32:50] “FOSS is the answer to the massive systematic risk that is the lack of technical capacity in the most dire of needs.” Spotlight [00:37:13] Justin's spotlight is a project he's been working on with his co-worker Camden called, conc: better structured concurrency for go. [00:38:04] Richard's spotlight is Ben Acker. [00:39:06] Kailash's spotlight is Matt's FormMail and Planet Source Code. Links SustainOSS (https://sustainoss.org/) SustainOSS Twitter (https://twitter.com/SustainOSS?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) SustainOSS Discourse (https://discourse.sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) Richard Littauer Twitter (https://twitter.com/richlitt?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) Justin Dorfman Twitter (https://twitter.com/jdorfman?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) Kailash Nadh LinkedIn (https://in.linkedin.com/in/kailashnadh) Kailash Nadh Website (https://nadh.in/) FOSS United (https://fossunited.org/) FOSS Pledge (https://fossunited.org/foss-pledge) Zerodha (https://zerodha.com/) paperd.ink (https://paperd.ink/) IndiaFOSS (https://indiafoss.net/) KochiFOSS (https://indiafoss.net/Kochi/2022) DelhiFOSS (https://indiafoss.net/delhi/2022) conc-GitHub (https://github.com/sourcegraph/conc/) Ben Acker GitHub (https://github.com/nvcexploder) Matts Script Archive-FormMail (http://www.scriptarchive.com/formmail.html) Planet Source Code (https://www.sourcecodester.com/weblink/planet-source-code.html) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Kailash Nadh.

Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.

Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 milligrams per day of chondroitin sulfate could reduce cardiac events 7-fold, this has a theoretical potential to hurt the microbiome. My preferred way of getting sulfur is 1.2-1.8 grams per kilogram bodyweight of total non-collagen protein, with an emphasis on animal protein. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Glutathione Intolerance: Getting to the Bottom of It Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.

KSQD 8-31-2022: History of regulations and legalization of recreational drugs and comments on cannabis potency; The problem of not enough donors for organ transplants -- new techniques to preserve donated organs; Viruses can alter body odor to attract mosquitos! Can you explain the change in CDC recommendations for addressing COVID-19? All about NMN, niacin and NADH supplements; Vitamin B12 and folic acid address non-alcoholic liver disease -- the importance of homocysteine; No new treatments for Herpes virus; More about Cannabis potency -- keep edibles away from children! Locusts sniff out human cancer?

Episode 27: “The Psychiatry of COVID-19” A Conversation with Dr. Emanuel Garcia “BIGGEST Disaster in Medical History!” ~ Dr Charles Hoffe Gives Riveting Speech In Vancouver, British Columbia, Canada Kim Iversen: Proof IRS Expansion Of 87,000 New Agents Is Designed To Target Middle Class Americans   Study: Regular consumption of citrus fruits can reduce dementia risk by 15% Tohoku University (Japan), August 4, 2022 Dementia continues to affect more people worldwide, and countries with aging populations like Japan are especially vulnerable. To address this matter, researchers from Tohoku University studied the health benefits of eating citrus fruits. According to the study findings, regular consumption of citrus fruits like oranges, grapefruits, lemons or limes could help reduce the risk of dementia among older adults by almost 15 percent. The research team hopes that the dietary approach could be both a simple and effective solution for dementia prevention. Findings from some cell and animal experiments have shown that citrus flavonoids can cross the blood-brain barrier and play a part in antioxidant and anti-inflammatory actions. Earlier studies suggest that this could help reverse and repair some forms of cellular damage. (next) Olive oil consumption found to reduce risk of death due to cancer, heart disease and Alzheimer's Harvard School of Public Health, August 14, 2022 According to a study, replacing butter or full-dairy fat with half a tablespoon or more of olive oil can help increase your chances of living longer. The study was conducted by experts from the Harvard T.H. Chan School of Public Health and published in the American Journal of Cardiology. The study revealed that people who used seven grams or more (at least half a tablespoon) of olive oil as a dressing or with bread had a reduced risk of dying from Alzheimer's disease, cancer, heart disease or respiratory disease compared to those who rarely or never consumed olive oil. Findings also showed that replacing 10 grams a day (about 3/4 tablespoons ) of butter, margarine, mayo or dairy fat with the same amount of olive oil was linked to an impressive eight to 34 percent lower risk of disease-related death. For the study, the researchers analyzed data from 60,582 healthy adult women and 31,801 healthy adult men from the Nurses' Health Study and the Health Professionals Follow-up Study. During the 28-year follow-up, the volunteers had a diet assessment every four years that asked them how often they consumed certain foods, fats and oils on average. The assessment also checked which brand or type of oils they used for cooking or at the table. (next) Cutting 1 gram from daily salt intake could ward off nearly 9 million cases of stroke/heart disease British Medical Journal, August 16, 2022 A modest cut of just 1 gram in daily salt intake could ward off nearly 9 million cases of heart disease and strokes and save 4 million lives by 2030, suggest the estimates of a modeling study published in the open access journal BMJ Nutrition Prevention & Health. Salt intake in China is one of the highest in the world, averaging 11 g/day—over twice the amount recommended by the Chinese government. High salt intake drives up blood pressure and therefore the risk of cardiovascular disease, which accounts for 40% of all deaths in China every year. The researchers set out to estimate the health gains that could be achieved by reducing salt intake across the nation, with the aim of helping to inform the development of a doable salt reduction program. Given that, on average, adults in China consume 11 g/day of salt, reducing this by 1 g/day should lower average systolic blood pressure by about 1.2 mmHg. And if this reduction were achieved in a year and sustained, some 9 million cases of heart disease and stroke could be prevented by 2030—4 million of them fatal. (next) Getting Adequate Amount Of Vitamin D Prevents Harmful Inflammation University of South Australia, August 7, 2022 A little bit of inflammation is integral to the human body's natural healing process. Chronic inflammation, however, can actually have the opposite effect. Constantly high levels increase one's risk of various serious diseases including but not limited to Type 2 diabetes, heart disease, and various autoimmune conditions. Now, a study by scientists at the University of South Australia reports a direct link between low levels of vitamin D and high levels of inflammation. This is the world's first ever genetic research project to focus on this topic. Study authors believe their work establishes an invaluable biomarker for identifying individuals at a higher risk of developing chronic illnesses with an inflammatory component. The research team used Mendelian randomization on the genetic data of 294 ,970 participants enrolled in the UK Biobank project. That analysis revealed a clear association between vitamin D and C-reactive protein levels, considered an indicator of inflammation. (next) Four Natural Options for Chronic Fatigue Syndrome GreenMedInfo, August 16th 2022 Chronic fatigue syndrome (CFS) is a complex long-term disorder affecting over 2 million Americans that is characterized by extreme fatigue and malaise that doesn't improve with rest.[i] A whopping 90% of chronic fatigue sufferers are undiagnosed[ii] and may find it difficult to carry on with normal activities such as work, school and household chores. At least 1 in 4 CFS patients are house-bound or bed-bound for long periods of time due to the disorder. While some studies demonstrate correlation between CFS and autoimmune system dysregulation,[v],[vi] the cause of CFS, also referred to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is still unknown. There is no known cure for CFS, with treatment generally focusing on symptom relief.We've identified four of the best natural options for chronic fatigue syndrome to provide safe, effective support to revitalize your body and spirit. Nicotinamide Adenine Dinucleotide (NADH) An essential element in the production of energy, nicotinamide adenine dinucleotide (NADH) is a coenzyme found in every cell in the human body. NADH is a critical factor in hundreds of metabolic processes, including healthy cell turnover (antiaging), converting food into energy and maintaining the integrity of DNA,[ix] an important factor in disease prevention. NADH has been studied extensively as a therapeutic for CFS, including a study comparing oral NADH with conventional therapy consisting of nutritional supplements and psychological therapy for a period of 24 months. To rule out specific comorbidities, immunological parameters and viral antibody titers were also evaluated at baseline and each trimester of therapy. Patients who received NADH had a dramatic and statistically significant reduction in symptoms during the first trimester.[x] Another trial on the stabilized oral form of NADH examined 26 qualified patients over a 12-week double-blind, placebo-controlled study. Subjects were randomized to receive either 10 milligrams (mg) of NADH or placebo for a four-week period, followed by a four-week “washout” period, after which subjects were switched to the alternate treatment for a final four-week period. Within this cohort of 26 subjects, eight patients, or 31%, responded favorably to NADH compared to just 8% (two patients) of the placebo group, with no severe adverse reactions related to treatment.[xi] Astragalus Astragalus is a traditional herbal remedy known for its adaptogenic qualities, meaning it can help protect the body from damage due to oxidative stress. A powerful antioxidant, astragalus is used to protect and support immunity, as a preventative against colds and upper respiratory tract infections, and to regulate healthy blood pressure, among other uses.[xii] Astragalus can even be applied topically for wound care thanks to antiviral properties. A 2009 study focused on the herbal formula Myelophil, a combination of two traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza, a member of the sage family. The Myelophil extract was given to the treatment cohort in either low- or high-dose groups of 3 or 6 grams of Myelophil daily. A control group was provided with a placebo and all groups were monitored for four weeks. Patients were surveyed for symptom severity and blood antibody arrays were taken to measure inflammatory cytokines, an important marker of disease symptoms. Results showed that even at low dosage (3 grams), Myelophil significantly decreased fatigue severity compared with placebo, though no changes in cytokine expression were noted.[xiii] Probiotics Probiotics have garnered the health spotlight in recent years, owing to their ability to support and protect the digestive tract. But probiotics can do more than improve gut health — they may also boost your brain and improve your mood. Brain fog is a key side effect of CFS and a potentially devastating one when it comes to impact on daily functioning. The same can be said for depression, another common hallmark of CFS. Studies reflecting the mood-boosting, clarity-producing effects of probiotics are cause for optimism for sufferers of chronic fatigue. A 2018 study in the journal Beneficial Microbes points to the role gut microbiota may play in CFS and fibromyalgia syndrome (FMS), which shares many features of CFS. A systematic review of studies was performed in this meta-analysis, encompassing randomized controlled trials and pilot studies of CFS or FMS conducted between 2006 and 2016. The administration of Lactobacillus casei for eight weeks was found to reduce anxiety scores, while treatment with Bifidobacterium infantis for the same period reduced inflammatory biomarkers.[xiv] Unhealthful intestinal ecology may play a role in CFS, as it plays a part in the health of the immune system. A 2009 study on probiotics' effects on energy level and symptomology for CFS patients found that, after four weeks of probiotic supplementation with strains of lactobacillus, acidophilus and Bifidobacterium, patients reported improved neurocognitive functions, though fatigue and physical activity scores were not significantly affected.[xv] Antioxidant Formulas Supplementing with antioxidants is another way to boost your body's defenses against the damaging effects of free radicals. By increasing the amount of antioxidant enzymes available to your cells, you may be able to prevent or even reverse the effects of oxidative stress that can cause systemic inflammation and fatigue. Oxidative stress as a factor in CFS was studied by researchers using a mouse model that stressed mice via chronic swimming. Mice treated with melatonin — a hormone with antioxidant effects — carvedilol — a medication that is 10 times more potent than vitamin E[xvi] — were observed to have significantly reduced immobilityperiods each day.[xvii] Similar results were observed when mice were administered an oral herbal compound (Withania somnifera (100 mg/kg), quercetin (50 mg/kg) and St. John's wort (10 mg/kg).)[xviii] These treatments further caused a significant reduction in lipid peroxidation, a sign of oxidative stress, and restored the GSH (glutathione) levels decreased by chronic swimming.[xix]

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Josh Rabinowitz is a Professor of Chemistry and Integrative Genomics at Princeton University, where his research focuses on developing a quantitative, comprehensive understanding of cellular metabolism through the study of metabolites and their fluxes. In this episode, Josh focuses the discussion on three main topics: metabolomics, NAD (and its precursors), and cancer metabolism. The metabolomics discussion starts with a broad definition of metabolism, metabolites, and fluxomics before diving deep into glucose metabolism, lactate as a fuel, movement of lactate, and the regulation of these substrates. He then gives a detailed explanation of the electron transport chain and Krebs cycle and their implications with respect to both drugs and nutrition while also explaining how NAD is central to the process of energy generation. He then discusses the age-related decline in NAD and what current literature says about efforts to increase NAD through intravenous or oral supplementation with the precursors NMN and NR, including whether doing so provides any advantage to lifespan or healthspan. Finally, Josh ends the conversation talking about cancer metabolism and how one particular intersection between cancer metabolism and immunotherapy might provide a hopeful outlook on the future of cancer treatment. We discuss: Josh's background and unique path to becoming a research scientist at Princeton [3:30]; What sparked Josh's early interest in metabolism [11:15]; Metabolomics 101: defining metabolites and how they are regulated [16:30]; Fluxomics: metabolism as a system in action [26:00]; The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation [33:30]; The important role of lactate as an alternate fuel [36:30]; Fasting lactate levels as a potential early indicator of metabolic dysfunction [48:00]; The beauty of the Krebs cycle and the role of NAD in energy production [53:15]; How the drug metformin acts on complex I of the electron transport chain [1:05:00]; The difference between NADH and NADPH [1:08:45]; NAD levels with age, and the efficacy of supplementing with intravenous NAD [1:10:45]; The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN [1:22:15]; Exploring the hypothesis that boosting NAD levels is beneficial [1:32:30]; Cancer metabolism and the intersection with immunotherapy [1:39:00]; Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more [1:46:15]; The challenge of treating pancreatic cancer [1:50:30]; Epithelial cancers that might respond to metabolic approaches to therapy [1:56:30]; Josh's hopeful outlook on the future of cancer treatment [1:59:00]; Nutritional approaches to cancer attenuation [2:00:15]; What makes Princeton University special [2:06:15]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological.  Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals.  Mr. Cash has an MS in physics from the University of Oklahoma.  As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business,  Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm.   In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer. 

In this episode, Alan Cash talks about oxaloacetate and the beginning of his journey in developing it as a nutritional supplement. He shares the ongoing research on oxaloacetate's benefits, especially for patients suffering from brain damage. He also dives into oxaloacetate's ability to increase muscle use before fatigue and reduce anxiety and depression levels in women experiencing PMS. If you want to learn more about oxaloacetate's many benefits and applications, then this episode is for you! Here are three reasons why you should listen to this episode: Learn what oxaloacetate is and how it can help slow the biological effects of ageing. Discover the numerous potential health benefits of oxaloacetate. Get to know Alan's journey in developing and manufacturing oxaloacetate as a nutritional supplement. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the world's greatest science and health minds? Then reach out to us at support@lisatamati.com, and we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey of how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions worldwide, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Quercetin and Trimethylglycine by NMN Bio Benagene, an oxaloacetate supplement by benaGene Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health to live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. ​100% vegan and non-GMO. ​The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! ​No other form of protein comes close to PerfectAminos Ketone Products by Keto-Pro Exogenous Ketones developed by Nutritionist and Body Building champion Richard Smith. Keto-Pro BHB Exogenous Ketones –  250g   MORE BHB per gram than other MARKET LEADERS. During In-house testing, Keto-Pro BHB raised ketones quicker, higher and for longer than other market leaders. Ketones My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [09:36] How Alan Found Out About Oxaloacetate Alan got sick and needed to undergo brain surgery. He found out that his pain and illness were related to ageing. As Alan researched more about ageing, he discovered calorie restriction, wherein organisms tend to live longer when they eat less. Increasing the ratio of Nicotinamide Adenine Dinucleotide (NAD) to NADH helps fight off ageing. Alan started looking into biomechanical pathways and found that oxaloacetate that can change the ratio of NAD from NADH to 900% in just two minutes. He started testing oxaloacetate using worms and realised that the activated pathway was the same as calorie restriction. [21:53] What is Oxaloacetate? Oxaloacetate is a naturally occurring molecule in our bodies during metabolism. It exists in every cell of the body and, therefore, is non-toxic. Oxaloacetate is considered a hot molecule right now, given how it can help moderate metabolism on a cell-by-cell basis. Increasing oxaloacetate affects metabolism, which is vital to some people. [25:38] Patenting Oxaloacetate  Tohoku University in Sendai, Japan, conducted research in the 1960s which found how oxaloacetate reduced fasting glucose levels in type one and type two diabetics.  At first, Alan ran into the problem of being unable to get a patent for oxaloacetate, a naturally occurring compound in the human body. He persevered and eventually was able to own patent rights based on how oxaloacetate can maintain its stable form of enol-oxaloacetate.  After rigorous testing, their products now have a shelf life of two to three years or more. [31:00] Oxaloacetate and the Warburg Effect Oxaloacetate is a potential drug for brain cancer such as glioblastoma. It also has the potential to reverse the Warburg effect, in which fermented glucose turns into lactate that a tumour feeds off. Giving Oxaloacetate to cancer cells changes the cancer metabolism cell by cell. There's a specific dosage where cancer cells stop reproducing. [38:03] Oxaloacetate and Glutamate Glutamate is a compound that fires off the neutrons in the brain. Excessive glutamate excites the neurons until they die, a process known as excitotoxicity. Many studies describe how we may reduce the risk of excitotoxicity.  Alan is looking into cognition through clinical trials with Alzheimer's disease patients. The study showed how oxaloacetate reduced glutamate levels. In the same clinical trial, they also found how oxaloacetate increased the amount of glucose the brain can take in. The brain can take in more glucose due to the signalling protein PGC-1 Alpha enabling the production of more mitochondria. [38:03] Oxaloacetate Can Improve Muscle Use Oxaloacetate also improves muscle use by 10% more before it goes into fatigue. 10% is a significant improvement for both top-end athletes and daily living. Alan has done a clinical trial that showed a 25% to 30% drop in fatigue levels within six weeks, even for people with chronic fatigue syndrome or ME/CFS for up to 30 years. NF-κB turns on genes that release a cytokine storm, which at high levels can lead to chronic inflammation seen in arthritis or long COVID patients. Animal models show that oxaloacetate led to a reduction of NF-κB's translocation to the nucleus by 70%, which turns off the cytokine storm.  People experiencing chronic fatigue can benefit from oxaloacetate's mechanism of producing new mitochondria.  [51:34] Increase Focus and Attention Using Oxaloacetate In animal models, oxaloacetate turns on the mechanism to increase the number of neurons in the brain and increase the length of the axons, the little tendrils that connect neurons. Alan did a critical trial on the effect of oxaloacetate on premenstrual syndrome (PMS), wherein he found a 50% drop in anxiety, depression and suicide ideation. Drugs have an immediate pharmacological effect. Another is the genomic effect with a cumulative property that takes about a month or more to see. Even after getting better from your illnesses, keep the ball rolling and don't stop intaking your medicine and supplements. 7 Powerful Quotes ‘We could see when we gave the oxaloacetate to them if they live longer, or if they didn't, so we could eliminate what were the critical genes. And, we were able to follow along with a pathway, and it turned out to be the exact same pathway as calorie restriction, which is really exciting.' ‘First of all, is oxaloacetate toxic? Well, it turns out it's a human molecule. It's in metabolism. It's in practically every cell of your body.' ‘Experiment and see what works and understanding some of these mechanisms is really important because then we can actually start to connect the dots of cells.' ‘The reality is most people are not going to have the perfect diet, not going to be in a perfect environment, can't maybe even afford to have great food, or organic food, or all of these things that restrict us from having the ideal.' ‘None of us are going to know what's around the corner for us but, if we can be in that preventative space and be understanding this more and more, then that is to me the most fascinating conversation we can have.' ‘What happens then is that they stop all their protocol, and the thing that they were doing and, “Now I'm fixed. I don't need it anymore.” And I'm like, “Hang on a minute, you don't drop the ball now. You're already underway. You got to stay underway. You got to keep it going.”' ‘You want that cumulative, and those epigenetic changes, and those long term changes.' Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Studies on Anti-diabetic Effect of Sodium Oxalcacetate Get benaGene Capsules containing oxaloacetate  Get TMG (Trimethylglycine) as the ultimate anti-aging combination with NMN  PerfectAmino Tablets by Bodyhealth Keto-Pro's D-BHB Exogenous Ketones - Chocolate Flavour Keto-Pro's Keto Bar - Chocolate Almond Brownie Colloidal Health's Colloidal Silver Black Cumin Seed Oil Connect with Alan Cash: LinkedIn About Alan Alan Cash is a physicist, biologist and geologist. He's also a professional entrepreneur and the CEO and Founder of Terra Biological LLC and MetVital, Inc.  Alan is also the clinical trials supervisor and medical researcher. He's currently pursuing the advancement and development of nutritional supplements containing oxaloacetate, which is known as a caloric-restriction mimetic compound. His research has brought profound breakthroughs addressing cognitive decline and anti-aging. If you want to reach out, you may connect with Alan via LinkedIn. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa