Podcasts about schistosoma

Today, Calvin Smith of Answers in Genesis Canada, goes through all of the latest evidence for evolution. Either that or he goes through some of the evidence for evolution from the last century...there's a bit of a disconnect between the title and the actual content.Cards:AiG Canada is Lying for Clicks!

On episode #61 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/1/20 - 8/14/24.  Host: Daniel Griffin and Sara Dong  Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral nPEP quick guide (AIDS Education & Training Center Program) Coformulated Bictegravir/Emtricitabine/Tenofovir Alafenamide PREP after sexual assault (OFID) Adopting Early Testing for Perinatal Hepatitis C (Journal of Pediatric Infectious Diseases Society) Bacterial Lower Rates of Staphylococcus aureus Bloodstream Infection in Patients on Hemodialysis Receiving Trimethoprim-Sulfamethoxazole Melioidosis Prophylaxis (OFID) Trimethoprim-Sulfamethoxazole for Staphylococcus Aureus Bacteremia Prophylaxis in Patients on Hemodialysis (OFID) Human monocytotropic ehrlichiosis(PLoS Neglected Tropical Diseases) Human granulocytotropic anaplasmosis (PLoS Neglected Tropical Diseases) Bifidobacterium and Lactobacillus Probiotics for Preterm Infants (JAMA Network: JAMA Pediatrics) Rapid Implementation of Blood Culture Stewardship (CID) BD BACTEC Blood Culture Bottle Shortage - (IDSA) Fungal The Last of US Season 2 (YouTube) Clinical characteristics and mortality risks among critically ill patients with culture-proven coccidioidomycosis(OFID) Poor Clinical and Microbiologic Outcomes in C. auris Bloodstream Infection (CID) Parasitic Soap is lethal for Schistosoma mansoni cercariae (PLoS Neglected Tropical Diseases) Treatment of uncomplicated hepatic cystic echinococcosis (Cochrane Library) Blood exposure to Babesia microti(Cambridge Core) Miscellaneous Absence of Cerebrospinal Fluid Pleocytosis in Encephalitis (CID) Encephalitis due to Infection with Normocellular Cerebrospinal Fluid (CID) Podoconiosis and mental health (PLoS Neglected Tropical Diseases) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

La esquistosomiasis es una enfermedad parasitaria aguda y crónica causada por trematodos sanguíneos (gusanos trematodos) del género Schistosoma.

Segundo o Ministério da Saúde, o Brasil tem 1,5 milhão de pessoas que vivem em áreas sob risco de contaminação por esquistossomose, transmitida por água contaminada, onde há presença de caramujos infectados pelo parasito Schistosoma mansoni. Neste episódio do Aqui tem Ciência, o pesquisador Guilherme Miranda, autor de tese doutorado defendida no Programa de Pós-Graduação em Parasitologia da UFMG, fala sobre a investigação de uma linhagem do parasito que infecta roedores silvestres e da possibilidade que esses animais também possam transmitir a doença para humanos.

On episode #34 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/20 – 8/2/23. Host: Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode FDA approves first treatment for molluscum contagiosum (FDA) Identifying children likely to benefit from antibiotics for Acute Sinusitis (JAMA) Impact of metagenomic next-generation sequencing of plasma cell-free DNA testing in patients with suspected infectious diseases (OFID) Impact of infectious diseases consultation in patients with candidemia at a multisite healthcare system (OFID) Relapsing babesiosis with molecular evidence of resistance to certain antimicrobials commonly used to treat Babesia microti infections (OFID) Seroprevalence of Chagas disease among people of Latin American descent (AJTMH) Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults (The Lancet) The human blood fluke, Schistosoma mansoni, harbors bacteria throughout the parasite's life cycle (JID) Health care provider knowledge regarding Alpha-gal syndrome (CDC) Music is by Ronald Jenkees

Endemi ‘Demam Keong' Bukti Negara Omong Kosong? Oleh. Nur Rahmawati, S.H. (Tim Penulis Inti NarasiPost.Com) Voice over talent: Dewi Nasjag NarasiPost.Com-Belum hilang dalam ingatan ketika pandemi Covid-19 melanda Indonesia dan melumpuhkan banyak aktivitas manusia. Kini, ratusan warga di Sulawesi Tengah terserang demam keong. Penyakit yang terbilang mudah penyebarannya ini tidak bisa dipandang sepele. Sebanyak 256 kasus demam keong di Sulawesi Tengah belum mampu diatasi dengan baik. Menurut Kepala Biro Komunikasi Kemenkes RI, dr. Siti Nadia Tarmizi, kesulitan memberantas si keong disebabkan tempat berkembangnya yang sangat kecil seperti di daun. Sehingga, demam keong masih sulit dieradikasi. (detik.com, 15/2/2023) Gejala Demam Keong Seseorang yang terinfeksi parasit Schistosoma awalnya akan mengalami ruam dan gatal pada kulitnya. Setelah satu sampai dua bulan akan muncul gejala berbeda, seperti demam, menggigil, nyeri otot, dan batuk. Reaksi ini terjadi pada tubuh akibat larva dari cacing, bukan karena cacing itu sendiri. Inilah gejala awal penyakit demam keong. Naskah selengkapnya: https://narasipost.com/2023/02/26/endemi-demam-keong-bukti-negara-omong-kosong/opini/ Terimakasih buat kalian yang sudah mendengarkan podcast ini, Follow us on: instagram: http://instagram.com/narasipost Facebook: https://www.facebook.com/narasi.post.9 Fanpage: Https://www.facebook.com/pg/narasipostmedia/posts/ Twitter: Http://twitter.com/narasipost

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.15.520648v1?rss=1 Authors: Miller, M. W., Vicente, L. C., Behra, M., Torres, A., Mendez, P., Rosa-Casillas, M., Bracho, D. P., Rosenthal, J. J. Abstract: The neglected tropical disease schistosomiasis impacts the lives of over 700 million people globally. Schistosoma mansoni, the trematode parasite that causes the most common type of schistosomiasis, requires planorbid pond snails of the genus Biomphalaria to support its larval development and transformation to the form that can infect humans. A greater understanding of neural signaling systems that are specific to the Biomphalaria intermediate host could lead to novel strategies for parasite or snail control. This study characterized a Biomphalaria glabrata neural receptor that is gated by the molluscan neuropeptide FMRF-NH2. The Biomphalaria glabrata FMRF-NH2 gated sodium channel (Bgl-FaNaC) amino acid sequence was highly conserved with FaNaCs found in related gastropods, especially the planorbid Planorbella trivolvis (91% sequence identity). In common with the P. trivolvis FaNaC, the B. glabrata receptor exhibited a low affinity (EC50: 3 x 10-4 M) and high specificity for the FMRF-NH2 agonist. Its expression in the central nervous system, detected by immunohistochemistry and in situ hybridization, was widespread, with the protein localized mainly to neuronal fibers and the mRNA confined to cell bodies. Colocalization was observed with the FMRF-NH2 tetrapeptide precursor in some neurons associated with male mating behavior. At the mRNA level, Bgl-FaNaC expression in the visceral and left parietal ganglia decreased at 20 days post infection by S. mansoni and in the shedding phase. Altered FMRF-NH2 signaling could be vital for parasite survival and proliferation in its snail intermediate host. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In today's episode, we finally get to fan-girl about our favorite model organism… except with a twist. C.elegans are cool and fun but in this episode we deep-dive into the life of the parasitic worm, Schistosoma mansoni, with graduate student Sarah Cobb. Time Stamps: 0:00- Intro 3:30-Woman in Science 6:60-Science of the Week 10:55-Interview with Sarah Cobb. Link to article from Lexus' Lab! https://rdcu.be/cSjDu

This week it's all about conglomerates. How do these sedimentary trash cans form and how can we classify them? Fun Paper Friday Turns out it may be difficult to estimate parasite population in poop, but that didn't stop this team! Krauth, Stefanie J., et al. "An in-depth analysis of a piece of s*@t: distribution of Schistosoma mansoni and hookworm eggs in human stool." PLoS neglected tropical diseases 6.12 (2012): e1969. (https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001969&fbclid=IwAR2VgJwL3Df7MBlFkF6takeHpn0Dt36tnnh6JKT_JNSTaifuH_5I1EW8wsM) Contact us: Show Support us on Patreon! (https://www.patreon.com/dontpanicgeo) www.dontpanicgeocast.com (http://www.dontpanicgeocast.com) SWUNG Slack (https://softwareunderground.org) @dontpanicgeo (https://twitter.com/dontpanicgeo) show@dontpanicgeocast.com John Leeman - www.johnrleeman.com (http://www.johnrleeman.com) - @geo_leeman (https://twitter.com/geo_leeman) Shannon Dulin - @ShannonDulin (https://twitter.com/ShannonDulin)

Hoy Nuevo Episodio de la Temporada 20 de tú PROGRAMA FAVORITO EN EL MICRO un Podcast de Citorush Training Center sobre #EnElMicro #Podcast #Broadcasting #citorushtc #citolovers #cursosonline #latinoamerica -

Dr. Keke Fairfax is an Associate Professor of Microbiology and Immunology and the Director of Equity, Diversity, and Inclusion at the University of Utah.  Her lab uses helminth parasite Schistosoma mansoni as a tool to understand the consequences of IL-4 induced immuno-modulation.  She explains how helminth infections can reduce the efficacy of childhood vaccinations, and how mentorship and networking can help minority scientists thrive in Utah.

I dag skal vi tale om to af medicinens helte! To af verdens mest uselviske mennesker, der har ofret deres egne kroppe for at fremme lægevidenskaben. Hverken brint eller parasitter kan holde disse videnskabsfolk fra at komme til sandheden. Hør med når Flemming fortæller om Nicholas Senn, der opdagede at man kunne bruge brint til at finde skudhuller i tarme og når Mark fortæller om Claude Barlow, der var så besat af snegleparasitter at han tog dem med hjem fra Egypten til USA. I sin sædblære!Hvis du vil være med til at optage live med os på Discord kan du støtte os på 10er og blive en af vores kernelyttere https://bit.ly/VU10er - hvis pengene er knappe kan du også bare tjekke vores Facebookgruppe ud, vi hygger max!Du kan også tjekke vores webshop: bit.ly/vushop. Vi har T-shirts, kaffekopper og tasker! Og meget mere! Der er også en hønsetrøje!Send os water hilarious science eller stil et spørgsmål på facebook, Instagram eller vudfordret@gmail.comTak til Christian Eiming for disclaimer.Tak til Barometer-Bjarke for Gak-O-meteretHusk at være dumme

The TWiPers solve the case of the Rural Man from North Carolina with Blurred Vision, and discuss the results of single-cell RNA sequencing of Schistosoma mansoni. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter RNAseq atlas of S. mansoni (Science) Hero: Kathleen Hussey Letters read on TWiP 191 Become a patron of TWiP Case Study for TWiP 191 Visit in Malawi, capital, teenage son of USAID worker urine has started to turn red. New to Malawi. On weekends go 2.5 hr east to lake and place to swim, Lake Malawi. Given pills, taken morning and night, clears up. Rest of family has been swimming in Lake Malawi. All in family are healthy.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

This episodee covers schistosoma!

With one of the most complex life cycles around, schistosomes are a fascinating subject for scientists. However, they also cause a tremendous amount of death and illness among the poor as a neglected tropical disease. Therefore, James Collins brings a full set of motivations to his research on the schistosome life cycle. Listen and learn Why schistosome male and female reproduction is unique among flatworms with elements still not understood, How their egg production causes the debilitating schistosomiasis symptoms, and Why studying their ability to hide from our immune system and other immunologically interesting facts about infectious diseases might lead to improved organ transplant processes.  James Collins is an associate professor with the University of Texas Southwestern Medical Center. He specializes in the shistosome parasite, researching significant elements of its basic biology. Originally from a geneticist and developmental biologist background, he became fascinated with flatworms and the schistosome stood out to him as both fascinating and also in desperate need of study: he realized how common and devastating their infections are among the world's poorest communities. About 200 million people have a schistosomiasis diagnosis and a quarter of a million people die every year from its effects. This neglected tropical disease affects so many yet only a small amount of labs are focusing on it. James Collins runs of these labs and hopefully his research will promote more effective schistosomiasis treatment. He explains their wild reproduction cycle that involves both snail and human hosts and a mysterious mating ritual that depends on a "hug" for the female to reach sexual maturity. Further, they have some significant attributes that make it hard to develop effective therapeutics. While there is one drug that can successful kill them called praziquantel, it is only effective in two of their life phases. In addition, studies show that because the parasite is so plentiful, reinfection is highly likely. Therefore, while infected members of a village may be treated with this drug, when doctors return a year later, the parasite infection rate is just as high. He explains that it is the high rate of egg production that causes the illnesses, with eggs finding their way to organs like the liver and causing massive inflammation and scaring that can lead to illness and death. Dr. Collins is studying both their ability to live for decades in human hosts as well as their ability to produce so many eggs in the hopes that such findings may lead to better schistosomiasis treatment.  For more about his work, see his lab's website: collinslab.org. Available on Apple Podcasts: apple.co/2Os0myK

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.07.285767v1?rss=1 Authors: JO, F., AS, A., RD, I., Anumudu, C. I. Abstract: Schistosomiasis remains a public health problem in developing countries. An ideal diagnostic test capable of detecting parasites as early as possible after the onset of infection is therefore highly desired. The identification of biomarker proteins associated with active infection and immune response may constitute the basis for the development of a successful diagnostic test. The aim of this study is to contribute to the development of protein biomarkers for schistosomiasis using a bioinformatics approach. The homologues of 36 previously identified urine biomarker proteins from a Schistosoma mansoni database, were identified in other Schistosoma species using SMARTBLAST and analyzed for similarities and differences using multiple sequence alignment. Of the 36 S. mansoni biomarker proteins, 29 had homologues with both S. haematobium and S. japonicum or either of S. haematobium and S . japonicum . Most of the 29 S. mansoni biomarker proteins aligned with their homologues with many conserved regions. However, some vital biomarker proteins like venom allergen-like proteins, which had been proposed as a putative drug and vaccine target, showed more semi conserved regions in which the amino acids had similar shape but weakly similar properties. The predictions of 12 markers found in all three species also show that treatment of infections may possibly benefit from the investigational drug Artenimol and specific nutraceuticals or supplements. Experimental evaluation is needed to confirm the potential of the proteins as biomarkers for early diagnosis of schistosomiasis and associated bladder cancer. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.03.282319v1?rss=1 Authors: Li, H., Wang, Z., Chai, S., Bai, X., Ding, G., Li, J., Xiao, Q., Miao, B., Lin, W., Feng, J., Gao, C., Li, Y., Li, B., Hu, W., Lin, J., Fu, Z., Xie, J., Li, Y. Abstract: Microtus fortis (M. fortis) so far is the only mammal host that exhibits intrinsic resistance against Schistosoma japonicum infection. However, the underlying molecular mechanisms of this intrinsic resistance are not yet known. Here we performed the first de novo genome assembly of M. fortis, comprehensive gene annotation and evolution analysis. Furthermore, we compared the recovery rate of schistosome, pathological change and liver transcriptome between non-permissive host M. fortis and susceptible host mouse at different time points after Schistosome infection. We reveal that Immune response of M. fortis and mouse is different in time and type. M. fortis activates immune and inflammatory responses on the 10th days post infection, involving in multiple pathways, such as leukocyte extravasation, antibody activation (especially IgG3), Fc-gamma receptor mediated phagocytosis, and interferon signaling cascade. The strong immune responses of M. fortis in early stages of infection play important roles in preventing the development of schistosome. On the contrary, intense immune response occurred in mouse in late stages of infection (28~42 days post infection), and cannot eliminate schistosome. Infected mouse suffers severe pathological injury and continuous decrease of important functions such as cell cycle and lipid metabolism. Our findings offer new insights to the intrinsic resistance mechanism of M. fortis against schistosome infection. The genome sequence also provides bases for future studies of other important traits in M. fortis. Copy rights belong to original authors. Visit the link for more info

Isso mesmo, você vai ter que ouvir para entender.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.11.146829v1?rss=1 Authors: Ishida, K., Mbanefo, E., Le, L., Lamanna, O., Pennington, L., Finkel, J., Jardetzky, T., Falcone, F., Hsieh, M. Abstract: The transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor is an important mediator of nociception and its expression is enriched in nociceptive neurons. TRPV1 signaling has been implicated in bladder pain and is a potential analgesic target. Resiniferatoxin is the most potent known agonist of TRPV1. Acute exposure of the rat bladder to resiniferatoxin has been demonstrated to result in pain-related freezing and licking behaviors that are alleviated by virally encoded IL-4. The interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE) is a powerful inducer of IL-4 secretion, and is also known to alter host cell transcription through a nuclear localization sequence-dependent mechanism. We previously reported that IPSE ameliorates ifosfamide-induced bladder pain in an IL-4- and nuclear localization sequence-dependent manner. We hypothesized that pre-administration of IPSE to resiniferatoxin-challenged mice would dampen pain-related behaviors. IPSE indeed lessened resiniferatoxin-triggered freezing behaviors in mice. This was a nuclear localization sequence-dependent phenomenon, since administration of a nuclear localization sequence mutant version of IPSE abrogated IPSEs analgesic effect. In contrast, IPSEs analgesic effect did not seem IL-4-dependent, since use of anti-IL-4 antibody in mice given both IPSE and resiniferatoxin did not dramatically affect freezing behaviors. RNA-Seq analysis of resiniferatoxin- and IPSE-exposed bladders revealed differential expression of TNF/NF-Kb-related signaling pathway genes. In vitro testing of IPSE uptake by urothelial cells and TRPV1-expressing neuronal cells showed uptake by both cell types. Thus, IPSEs nuclear localization sequence-dependent therapeutic effects on TRPV1-mediated bladder pain may act on TRPV1-expressing neurons and/or may rely upon urothelial mechanisms. Copy rights belong to original authors. Visit the link for more info

Schistosoma, die Pärchenegel mit der immunologischen Tarnkappe, leben in Schnecken als Zwischenwirte und werden durch Kontakt mit Süßwasser auf den Menschen übertragen. Till Koch und Stefan Schmiedel diskutieren über die Schistosomiasis (Bilharziose), die durch die verschiedenen Schistosoma-Arten verursachten Wurmerkrankungen. Dr. Stefan Schmiedel ist Oberarzt und Infektiologe am UKE in Hamburg.

The TriTWiPomonads solve the case of the Child Who Passed a Worm, and reveal recombination between bovine and human schistosome species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: S. bovis and S. haematobiumhybrids (PLoS Path) Hero: Ann Bishop Letters read on TWiP 169 Case Study for TWiP 169 9 yo boy brought into mobile clinic set up in small village Bocas del Toro archipelago. Initially had red painful eye a few months ago, lasted 1-2 weeks. Eye no longer red but has issues with vision in the eye. On eye exam, some peripheral vision, but no sharp clear vision. Notes retinal retraction, seems quiet granuloma over macula of affected eye. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Show notes: In the show, The Bio Busters professors, Dr. A and Dr. C, discuss inflammatory bowel diseases. The professors discuss Crohn's disease and ulcerative colitis, focusing on etiology, symptoms and signs, as well as treatments and therapy (conventional and unconventional). Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show. Music by Bahaa Naamani Email us at thebiobusters@gmail.com   References: http://www.crohnscolitisfoundation.org/what-are-crohns-and-colitis/what-is-ulcerative-colitis/ Norman JM et al.. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell. 2015 Mahesh Gajendran et al. A comprehensive review and update on ulcerative colitis. Disease-a-Month. 2019 Basso Paulo José et al. Microbial-Based Therapies in the Treatment of Inflammatory Bowel Disease – An Overview of Human Studies. Frontiers in Pharmacology. 2019 Eichenberger RM et al. Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. Frontiers in Immunology. 2018 Liu Y et al. Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress. World Journal of Gastroenterology. 2017 Summers RW et al. Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2003 Summers RW et al. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology. 2005

Mindestmengen für Operationen - Routine bringt mehr Sicherheit für Patienten / Kohleausstieg - Was brauchts zum Gelingen / Bilharzioseparasit "Schistosoma" in Europa - Woher der Erreger ursprünglich kommt und warum er sich hier halten kann / Durchblicker: Ameisen mögen keine Überraschungen

This episode involves a Nature Walk contest, "Who's That Non-Bird: Killer Edition". (We'll save the killer birds for another day.) The contest question is this: which non-birds are responsible for the most human deaths in the world per year? Warren asks the rest of us to guess the top 11. Here's a little foreshadowing: Warren will cite some stats for non-animal causes of death for contrast, and John will contest them furiously. This contest is only one episode, but it's still surprisingly long, or at least it feels that way... If you want to correct any of Warren's statistics, send us an email (maskedman@limitedappeal.net). Theme music courtesy of General Patton vs. The X-Ecutioners and Ipecac Recordings.

The TWiPwalas solve the case of the Woman with a Worm in Her Eye, and discuss the role of nitric oxide in the resistance of rats to Schistosoma japonicum. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Nitric oxide blocks schistosome development (PNAS) Photo credit: Dave the Sheep Shearer Letters read on TWiP 139 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twip. Case Study for TWiP 139 Seen at Columbia Medical Center, a crossover. Woman in 30s returns to US after 2 years in Peace Corp, Cameroon and Gabon. On medical exam 2 years earlier: eosiniphilia noted, no diagnosis reached. Now comes to NYC 2 years later to attend grad school, again eosinophilia noted. Asymptomatic. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Dickson returns to the TWiP hosts to solve the case of the Woman from Colorado With Loose Stools, and explain how single-sex infection with female Schistosoma mansoni reduces hepatic fibrosis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: ASM Grant Writing Online Course Single-sex Schistosoma infection (PLoS NTD) Asterix the Gaul Letters read on TWiP 135 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twip. Case Study for TWiP 135 Patient seen in clinic by Daniel's colleague, living in Queens, needs home care. Man with wound on foot, needed daily care. Living 9 months, recently developed painful blister, he put his foot in water, got great relief, blister opened up. Open lesion did not look normal, there was something in blister. Went to see parasitologist, saw something there, wrapped it around piece of wood. Not previously seen a physician, no surgeries, knew little family history. New to our country, where could he have possibly come from? Rural part of some country. Resource limited region. How many days of treatment will he need? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Hosts: Vincent Racaniello and Daniel Griffin Vincent and Daniel solve the case of the Family with Eosinophilia, and discuss HIV-1 infection and genome integration in the blood fluke Schistosoma mansoni. Become a patron of TWiP. Links for this episode: Family cluster of eosinophilia (Clin Inf Dis) Dientamoeba fragilis (Wikipedia) Parasites without borders HIV integrates into Schistosoma genome (PLoS Path) Image credit Letters read on TWiP 119 This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Case Study for TWiP 119 This one will be kinder and gentler case. Back in Thailand but could be in several places. 25 yo Thai woman from Bangkok, to hospital, chief complaint facial swelling. Eats typical Thai diet (see previous episodes!) Som tum, etc fish that is not cooked. Migratory - moves around face. Not tender, but mild itchiness. For about a week, no pain. Healthy, no past med/surg history, family all fine. HIV negative, no drugs, no travel. On examination, has swelling on right side, 3-4 cm raised, little redness, firm, does not feel like fluid filled. No fever, no GI problems, no bloods. WBC up, eosinophils up.  Send your case diagnosis, questions and comments to twip@microbe.tv

In der vorliegenden Arbeit wurden insgesamt 497 Patienten mit mikroskopisch gesicherten Helminthiasen hinsichtlich epidemiologischer und klinischer Daten sowie auf indirekte Laborparameter (Eosinophilie und Gesamt-IgE-Erhöhung) und die Resultate immundiagnostischer Verfahren untersucht. Hierbei wurden die Ergebnisse von 329 Reiserückkehrern und 168 Migranten mit jeweils 8 Diagnosen (Ankylostomiasis, Askariasis, Fasziolose, Filariose, Schistosomiasis, Trichinose, Trichuriasis, Mischinfektionen) miteinander verglichen. Für die Evaluation der immundiagnostischen Verfahren wurden vorhandene Seren mit 9 Antigenen (Schistosoma mansoni, Onchocerca volvulus, Dirofilaria imitis, Trichinella spiralis, Fasciola hepatica, Toxocara canis, Strongyloides ratti, Ascaris lumbricoides, Ascaris suum) getestet. Vorbestehende Ergebnisse aus der Routinediagnostik wurden mit einbezogen. Als Kontrollen dienten die Seren von 80 gesunden Personen ohne Hinweise auf eine Wurmerkrankung in der Vorgeschichte und ohne einen vorherigen Aufenthalt in den Tropen oder Subtropen. Die epidemiologischen Daten zeigen eine eindeutige Zuordnung von Schistosomiasis und Filariosen auf den afrikanischen Kontinent, während die Geohelminthiasen (Erkrankungen durch Helminthen, deren präadulte Stadien sich im Erdboden entwickeln und die eine reise- bzw. migationsmedizinisch wichtige Bedeutung haben) von den Reiserückkehrern vorwiegend in Asien, vorzugsweise in Südostasien, akquiriert wurden. Die Migranten stammten hauptanteilig aus Afrika, es waren dennoch alle wesentlichen tropischen und subtropischen Gebiete vertreten. Die Auswertung der klinischen Symptomatik zeigte ein klares Erscheinungsbild der Filariosen mit Hauterscheinungen und Juckreiz sowie die überdurchschnittlich häufige Angabe von Harnwegsbeschwerden bei Infektionen mit Schistosoma haematobium. Bei allen Geohelminthosen und Infektionen mit Schistosoma mansoni herrschte bei den Reiserückkehrern eine gastrointestinale Symptomatik vor, während die Migranten insgesamt mehr unspezifische Beschwerden aufwiesen. Circa ein Drittel der Patienten war asymptomatisch. Die Sensitivität der Eosinophilie als indirekter Parameter lag in dieser Arbeit für Wurmerkrankungen im Allgemeinen bei 45%, variierte aber von Diagnose zu Diagnose erheblich, wobei kein signifikanter Unterschied zwischen Reiserückkehrern und Migranten zu finden war. Eine Hypereosinophilie fand sich überdurchschnittlich häufig bei Migranten mit Filariose und bei Reiserückkehrern mit Strongyloidiasis; die Patienten mit Askariasis und Trichuriasis zeigten dagegen kaum Abweichungen von der Kontrollgruppe. Eine Gesamt-IgE-Erhöhung fand sich insgesamt bei 43% der Patienten, wobei es einen signifikanten Unterschied zwischen Reiserückkehrern (25%) und Migranten (75%) gab. Besonders hohe IgE-Serumspiegel konnten bei Migranten mit Schistosomiasis, Strongyloidiasis und Ankylostomiasis gefunden werden. Davon abweichend waren allerdings die Resultate von Reiserückkehrern mit Mischinfektionen. Bei diesen Patienten konnte eine unerwartet häufige Gesamt-IgE-Erhöhung verzeichnet werden (75%). Die serologischen Untersuchungen zeigten zumeist eine gute Sensitivität, aber erhebliche Kreuzreaktionen mit verwandten und nicht verwandten Wurmarten, sodass eine Differenzierung nur für die Schistosomiasis und die Filariosen valide gewährleistet ist. Der im Rahmen dieser Arbeit entwickelte Ascaris suum-ELISA, ergab eine Sensitivität von 60% und eine Spezifität von 90% und hat in der Routinediagnostik eine gewisse Berechtigung, da der Ascaris lumbricoides-ELISA inakzeptable Ergebnisse erbrachte. Zusammengefasst stellt die Eosinophilie einen wichtigen hinweisenden Parameter auf eine Wurminfektion dar, ist aber keine ausreichende Screeningmethode bei Rückkehr aus Endemiegebieten. Die serologischen Untersuchungen ergaben eine sinnvolle diagnostische Ergänzung bei der Schistosomiasis und den Filariosen. Eine Differenzierung der Geohelminthosen ist weiterhin nur durch direkte Nachweismethoden, wie z. B. dem Ei- bzw. Larvennachweis im Stuhl oder in einem Körpergewebe, verlässlich möglich.

This month, supergenes and their role in evolution, and what shapes the genetic composition of human Schistosoma mansoni. See acast.com/privacy for privacy and opt-out information.

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson explain the genetic and molecular basis of drug resistance in Schistosoma mansonii. Links for this episode: Basis of resistance to oxamniquine (Science) Oxamniquine (Wikipedia) Letters read on TWiP 67 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email  

Background: Acute schistosomiasis constitutes a rare but serious condition in individuals experiencing their first prepatent Schistosoma infection. To circumvent costly and time-consuming diagnostics, an early and rapid diagnosis is required. So far, classic diagnostic tools such as parasite microscopy or serology lack considerable sensitivity at this early stage of Schistosoma infection. To validate the use of a blood based real-time polymerase chain reaction (PCR) test for the detection of Schistosoma DNA in patients with acute schistosomiasis who acquired their infection in various endemic regions we conducted a European-wide prospective study in 11 centres specialized in travel medicine and tropical medicine. Methods: Patients with a history of recent travelling to schistosomiasis endemic regions and freshwater contacts, an episode of fever (body temperature >= 38.5 degrees C) and an absolute or relative eosinophil count of >= 700/mu l or 10%, were eligible for participation. PCR testing with DNA extracted from serum was compared with results from serology and microscopy. Results: Of the 38 patients with acute schistosomiasis included into the study, PCR detected Schistosoma DNA in 35 patients at initial presentation (sensitivity 92%). In contrast, sensitivity of serology (enzyme immunoassay and/or immunofluorescence assay) or parasite microscopy was only 70% and 24%, respectively. Conclusion: For the early diagnosis of acute schistosomiasis, real-time PCR for the detection of schistosoma DNA in serum is more sensitive than classic diagnostic tools such as serology or microscopy, irrespective of the region of infection. Generalization of the results to all Schistosoma species may be difficult as in the study presented here only eggs of S. mansoni were detected by microscopy. A minimum amount of two millilitre of serum is required for sufficient diagnostic accuracy.

Thu, 10 Nov 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13878/ https://edoc.ub.uni-muenchen.de/13878/1/Scharmann_Claas.pdf Scharmann, Claas

Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.

Noorderlicht Radio 30-10-2009: Reportage over de Vlaamse parasitologen Tine Huyse en Bruno Gryseels, die in Brazilië poep en slakken verzamelen voor hun onderzoek naar de Schistosoma-parasiet.

Ectopic late cutaneous schistosomiasis is usually preceded or accompanied by visceral schistosomiasis infection. Our patient presented the very rare case of late cutaneous schistosomiasis as an isolated skin manifestation. Perigenital lesions occurred 1 year after contact with infested water. Identification of the few eggs remaining in the late lesion among the dense cellular infiltrate was difficult. Electron-microscopic studies clearly demonstrated the characteristic eggshell ultrastructure. Copyright (C) 2000 S. Karger AG, Basel.