Podcasts about Naloxone

Une entreprise pharmaceutique de Saint-Hyacinthe propose une solution locale à la crise des surdoses : une naloxone prête à l’emploi, plus simple, plus sécuritaire, et fabriquée ici au Québec. Dans un contexte de dépendance aux produits importés, cette innovation pourrait sauver des vies tout en soutenant la production pharmaceutique locale. Pourquoi les provinces continuent-elles d’acheter ailleurs? Entrevue avec Bernard Bouchard, responsable du soutien clinique chez Sterinova Regardez aussi cette discussion en vidéo via https://www.qub.ca/videos ou en vous abonnant à QUB télé : https://www.tvaplus.ca/qub ou sur la chaîne Youtube QUB https://www.youtube.com/@qub_radioPour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

In the ongoing effort to reduce fentanyl-related deaths, the California government declared that the state will now sell the overdose medication Naloxone at a highly reduced price as part of Governor Newson's plan to lower the prices of prescription drugs. KCSB's Abbey Guerrero has the story.

In this episode of The Poison Lab, host Ryan Feldman is joined by Dr. Amy Zosel, a medical toxicologist, emergency physician, and educator. Together, they use real poisoning cases to practice identifying toxins and flexing their toxic differential The conversation dives into intriguing and challenging toxicology cases, with a focus on educating listeners about real-world poisoning scenarios, myth-busting internet misinformation, and providing practical clinical insights. Mini episode with Dr. Robert Bassett on Remembering Poisonous Mushrooms Dr. Zosel and Ryan discuss:14:15 Case 1 33:04 Case 2News story37:00 Case 3 New story48:00 Case 4 News storyUS outbreak "Robocough"Study about Naloxone in Clonidine overdose++Spoiler++: Below this will be key takeaways regarding managing the poisonings discussed, it may ruin your experience if you are guessing the poisons Key Takeaways:Amatoxin Mushroom Poisoning: The classic delayed onset of severe GI symptoms, followed by a latent phase, can mask progressive liver damage. Early recognition and treatment with hydration, silibinin, and possible liver transplant are critical.Tetramine Toxicity: Known for causing refractory seizures, tetramine is a rare but serious poisoning often requiring aggressive supportive care and anticonvulsants.A Lethal mushroom hiding in edible mushrooms Mushroom foraging dangerResources Mentioned:National Poison Control Hotline: 1-800-222-1222National Suicide Prevention Lifeline: 1-800-273-8255SAMHSA Free Helpline: 1-800-662-HELP (4357)Follow The Poison Lab:Twitter: @LabPoisonInstagram: @tox_talkWebsite: www.ThePoisonLab.comSubscribe and Review:Love what you're hearing? Help us reach more toxicology enthusiasts by leaving a review on Apple Podcasts, Spotify, or wherever you listen. Don't forget to share this episode with...

A Nashville convenience store installs a naloxone vending machine. Aldi plans to open more than 200 stores in 2025. And Walmart announces plans to remodel more than 650 stores in 47 states.

It's an overcast Saturday morning in late March and Station 20 West, located on 20th Street West and Avenue L South, is buzzing with activity.People have gathered to learn more about Naloxone, how to safely administer it to someone overdosing from opioids, and to talk about what can be done to help our community get through this difficult point in time.Saskatoon's drug and overdose crisis has been all over the news. A CBC story notes the Saskatoon Fire Department has responded to 935 overdose incidents or suspected opioid poisonings since the start of the year. That's compared to 376 incidents in the same time period last year.The Saskatoon Library closed two branches for a month over safety and overdose concerns, and Prairie Harm Reduction, which we have featured on the podcast several times, temporarily paused its operations in March to give its staff an opportunity to deal with the trauma they are seeing every day in our city. I think the local media and the Hard Knox Talks podcast have done an exemplarily job of telling the stories amidst this crisis, and I struggled to find a way to get into the crisis through the podcast. Then I learned about this gathering at Station 20 West and thought there might be some people who would be willing to share their stories. So my wife and I went on this Saturday morning and we met some pretty incredible people. We also learned how to administer Naloxone, which you will hear in this episode.We met Colleen Christopherson-Cote, Board Chair for Station 20 West, University of Saskatchewan doctoral candidate, Maryellen Gibson, and  Assistant Professor in the School of Public Health at the University of Saskatchewan, Barbara Fornssler. My sincere thanks to them for sharing their passion for helping others and their community in this episode. You can listen and follow YXE Underground wherever you find your favourite podcasts including Apple Podcasts, Spotify or on the website. Please feel free to leave a 5-star review if you like you what you hear. These reviews help the podcast get into more podcast feeds so I really do appreciate the support. Cheers...Eric  Host, Producer, Editor: Eric AndersonTheme Music: Andrew DicksonWebsite: https://www.yxeunderground.comRecorded: On Treaty 6 Territory and the traditional homeland of the Metis

In today's newscast, Monterey County supervisors and members of the public are frustrated at the slow pace of cleanup from the January battery plant fire in Moss Landing. And starting this week, Californians can buy the drug Naloxone at a discount on a state-run website.

The death of Pope Francis is being felt around the world. And right here in California, millions of Latino Catholics are mourning not just the loss of a spiritual leader, but someone who, for many, felt like one of their own. Pope Francis was the first from Latin America. He spoke often about immigration, inequality, and the dignity of the poor. Guest: Jeff Guhin, Sociology Professor, UCLA Starting this week, Californians can buy naloxone at a discount on a state-run website. Naloxone, also known as Narcan, is a drug used to reverse opioid overdoses. Reporter: Kristen Hwang, CalMatters A California state labor board says Governor Gavin Newsom may have violated the law when he issued an executive order calling state employees back into the office four days per week. Reporter: Megan Myscofski, CapRadio Learn more about your ad choices. Visit megaphone.fm/adchoices

Surgeon and author Jeffrey A. Singer discusses his article "The FDA's outdated prescription rules are failing women and opioid users." He argues that the U.S. Food and Drug Administration's requirement for prescriptions for certain safe medications, specifically hormonal contraceptives and the opioid antidote naloxone, creates significant barriers to access and reflects outdated paternalism. Jeffrey highlights that obtaining prescriptions for birth control pills adds cost and inconvenience, disproportionately affecting women who report difficulty accessing appointments, despite decades of recommendations from major medical groups like the American College of Obstetrics and Gynecology and the American Medical Association for over-the-counter access, a standard in over 100 countries. He critiques the FDA's slow and partial move to allow only one type of progestin-only "mini-pill" over-the-counter, contrasting it with the easier access to emergency contraception. Similarly, Jeffrey discusses the years-long delay in making naloxone available over-the-counter, despite its proven safety, effectiveness by laypeople, availability in other countries, and requests from experts and even the FDA itself, noting how manufacturer financial incentives and state-level workarounds preceded the eventual, partial FDA approval for the nasal spray form. Our presenting sponsor is Microsoft Dragon Copilot. Microsoft Dragon Copilot, your AI assistant for clinical workflow, is transforming how clinicians work. Now you can streamline and customize documentation, surface information right at the point of care, and automate tasks with just a click. Part of Microsoft Cloud for Healthcare, Dragon Copilot offers an extensible AI workspace and a single, integrated platform to help unlock new levels of efficiency. Plus, it's backed by a proven track record and decades of clinical expertise—and it's built on a foundation of trust. It's time to ease your administrative burdens and stay focused on what matters most with Dragon Copilot, your AI assistant for clinical workflow. VISIT SPONSOR → https://aka.ms/kevinmd SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

Send us a text In this powerful and deeply honest conversation, Melissa McGillivray and Jen Chouinard join me in the studio to share their lived experiences as service providers. Drawing on their expertise and personal insight, they break down the mental and emotional toll of working on the front lines of Saskatoon's overdose crisis.Through the lens of a registered nurse and a social worker/researcher, we explore the stark realities of substance use in the community, service provider burnout, compassion fatigue, moral injury, and the growing need for trauma-informed support—both for those experiencing addiction and for those offering care.

I'm joined by Gloria Malone from Vital Strategies and Keli McLoyd, Director of the Overdose Response Unit for the City of Philadelphia, to talk about the You Can Save Lives campaign. At a time when overdose deaths continue to rise in the Black community, this initiative raises critical awareness about the life-saving power of Naloxone and the urgent need for overdose prevention strategies that match the scale of the crisis. They share how Philadelphians can access free Naloxone and Fentanyl test strips. Learn more at youcansavelives.org and substanceusephilly.comFollow Vital Strategies on Instagram: @vitalstrategies  Later in the show, we spotlight a powerful nonprofit working to uplift Philadelphia neighborhoods by renovating aging homes: Rebuilding Together Philadelphia. I speak with Rudolph “Coach” Edge, a homeowner whose block was transformed by this initiative; Stefanie F. Seldin, President and CEO of Rebuilding Together Philadelphia; and Craig Carnaroli, Senior Executive Vice President at the University of Pennsylvania, a key supporter of this community-centered work.Learn more at rebuildingphilly.orgFollow Rebuilding Together Philadelphia:Instagram: @rtphiladelphiaFacebook: facebook.com/rebuildingphillyLinkedIn: Rebuilding Together Philadelphia

In this eye-opening episode we dive deep into the troubling intersection of the opioid epidemic and the pharmaceutical industry's influence. While Naloxone is marketed as a lifesaver, it's part of a larger cycle where the same companies that push opioids onto the market also profit from the treatments designed to counteract the very addiction they fueled. We'll explore exactly what you need to know about Naloxone and how to help you learn where your state is spending its opioid dollars. We will also discuss why short term solutions are the most lethal and learn how to approach addiction from a holistic and long term approach. Studies Referenced: https://www.kuer.org/health/2025-02-20/utah-counties-received-millions-to-battle-the-opioid-epidemic-many-havent-spent-a-dime More Living Proof: https://yourlivingproof.com Free Masterclass: https://yourlivingproof.com/free-masterclass Also available on Youtube: https://www.youtube.com/@your_living_proof

In this episode, hosts Dr. Jess Steier and Dr. Sarah Scheinman engage with Suhanee Mitragotri, a Harvard undergraduate and co-founder of the Naloxone Education Initiative, to discuss the opioid crisis in the United States. They explore the scale of the crisis, the importance of naloxone in reversing overdoses, and the gaps in education regarding opioids and harm reduction. The conversation emphasizes the need for increased awareness and education, particularly among youth, to combat the ongoing epidemic. Email Suhanee: suhaneemitragotri@college.harvard.edu https://steppingstrong.bwh.harvard.edu/naloxone-administration-program/ https://journalofethics.ama-assn.org/article/how-fda-failures-contributed-opioid-crisis/2020-08 https://pmc.ncbi.nlm.nih.gov/articles/PMC8154745/ https://www.fcc.gov/reports-research/maps/connect2health/focus-on-opioids.html https://www.cdc.gov/overdose-prevention/about/understanding-the-opioid-overdose-epidemic.html ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

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The fight against the opioid crisis continues... and Utah has just surpassed an important milestone. Joining me live is Dr. Jennifer Plumb, medical director of Utah Naloxone.

In this episode of the Prehospital Care Research Forum's Journal Club, we discuss the findings of a qualitative study examining the acceptability of providing take-home naloxone kits by EMS to individuals at risk of opioid overdose. Discover the insights from the study, including patient perspectives, potential barriers, and the implications for overdose prevention strategies. Join us for a thought-provoking conversation on how EMS can play a pivotal role in combating the opioid crisis.https://www.tandfonline.com/doi/full/10.1080/10903127.2024.2435034?src=

Our speaker for the session is Summer Peregrin, PharmD, Ambulatory Clinical Pharmacist at Dignity Health Medical Group — Arizona, and one of the authors of the Opioid Toolkit for CommonSpirit Health.Learning ObjectivesReview the current state of the opioid epidemicRecognize signs and symptoms of a potential opioid overdoseBuild greater understanding of naloxone and its use to treat an opioid overdoseSummarize best practices in emergency response to an opioid overdosePanelistsShawna Sharp, RN, System Director Clinical Transformation, Physician EnterpriseMarijka Grey, MD, MBA, FACP, System Vice President Ambulatory Transformation & Innovation, Physician Enterprise

Additional resources to check out:April 22nd FREE Webinar (Noon-1pm CT) Registration: Naloxone Training: Responding to Opioid OverdoseSAMHSA's Overdose Prevention and Response Toolkit (see page 8 for common Opioid Overdose Reversal Medications available to the public, and page 18 for Appendix 1 and page 19 for Appendix 2)What is Naloxone? from the National Institute of HealthRecent drug overdose data - Drug Overdose Deaths in the United States, 2003–2023 from the CDC's National Center for Health StatisticsPrevent & Protect - This website is a free resource for opioid safety and opioid overdose prevention developed by public health and addiction medicine experts.The National Harm Reduction Coalition's Naloxone Finder - Harm reduction is a movement to reduce drug-related deaths and harmful consequences of drug use.-If you are interested in QPR training, visit: https://www.agrisafe.org/QPR/Sign up for the AgriSafe newsletter: https://www.agrisafe.org/newsletter/View upcoming webinars: https://www.agrisafe.org/events/-Directed by Laura SiegelHosted by Linda EmanuelEdited by Joel Sharpton for ProPodcastingServices.comSpecial Guest: Dr. Tara Haskins

This month, how films are helping neuroscientists link brain activity patterns to specific thought processes, a breakthrough in managing opiate overdose, a technique to study animal teamwork, extracting more information from brain scan data, and how childhood adversity blunts later fear responses... Get the references and the transcripts for this programme from the Naked Scientists website

Can reversing sedation be too much of a good thing? Flumazenil is a powerful benzodiazepine antagonist, but its use comes with both benefits and risks. In this episode of Everyday Oral Surgery, we welcome back Dr. Jake Stucki, a resident doctor at Case Western Reserve University School of Dental Medicine, to break down the benefits and drawbacks of flumazenil. In our conversation, we delve into the benefits, risks, cost considerations, and usage of flumazenil in oral surgery sedation. We explore using naloxone, its potential to reverse opioid effects, the associated costs of using it, and its potential for residual sedation. You'll also learn about the common misconceptions surrounding flumazenil, patient contraindications, guidelines on best practices, and more. Join us to learn about the fundamentals of flumazenil and how to use it effectively and safely in your practice with Dr. Jake Stucki. Tune in now!Key Points From This Episode:Learn about flumazenil's usage, its effects on patients, and why it is important.The associated costs, how it can be administered, and the correct dosage to use.Explore the benefits of flumazenil in oral surgery and patient recovery.  Uncover the potential risks surrounding re-sedation and other vital considerations.When not to use the drug and how it is commonly used in clinical practice.Find out about the downsides of using flumazenil and the complications it can cause.Hear about The Joint Commission's perspective on the use of flumazenil.Naloxone and how its usage and dosage are different from flumazenil.Discover an alternative approach for extracting maxillary upper third molars.Links Mentioned in Today's Episode:Dr. Jake Stucki on LinkedIn — https://www.linkedin.com/in/jake-stucki-ab19a593/  Case Western Reserve University School of Dental Medicine — https://case.edu/medicine/The Joint Commission — https://www.jointcommission.org/Dexter — https://www.imdb.com/title/tt0773262/Cobra Kai — https://www.imdb.com/title/tt7221388/Talking to Strangers — https://www.amazon.com/Talking-Strangers-Should-about-People/dp/0316478520/Everyday Oral Surgery Website — https://www.everydayoralsurgery.com/ Everyday Oral Surgery on Instagram — https://www.instagram.com/everydayoralsurgery/ Everyday Oral Surgery on Facebook — https://www.facebook.com/EverydayOralSurgery/Dr. Grant Stucki Email — grantstucki@gmail.comDr. Grant Stucki Phone — 720-441-6059

In this conversation, Von interviews April Ella, the director of operations at A New Path, a San Diego-based organization focused on harm reduction and advocacy for therapeutic drug policies. They discuss April's journey from fashion to harm reduction, the impact of fentanyl and the emerging drug Trank, the concept of harm reduction, the historical context of the war on drugs, and the importance of naloxone in preventing overdoses. April shares insights on the stigma surrounding addiction and the various services offered by A New Path to support individuals and families affected by substance use disorders.Chapters (00:00) Introduction to Harm Reduction and A New Path(04:47) April's Journey from Fashion to Harm Reduction(09:28) Understanding Fentanyl and Its Impact(17:26) The Myths and Realities of Fentanyl(21:37) Defining Harm Reduction in Drug Use(24:32) Personal Experiences and Harm Reduction Strategies(24:48) Harm Reduction in the Drug Community(27:33) Understanding Addiction as a Disease(30:27) The Need for Safe Consumption Sites(33:24) The War on Drugs: A Historical Perspective(39:20) The Ongoing Impact of Drug Policies (46:07) Reframing Addiction: A Public Health Issue(47:47) The Impact of Fear Mongering in the Drug War(52:42) Understanding Tranq: The New Drug on the Scene(55:59) Harm Reduction: A Bridge to Recovery(01:02:32) Naloxone: Saving Lives Through Education(01:11:07) A New Path: Community Services and Support https://linktr.ee/newpathnarcanproject https://www.instagram.com/newpathnarcanproject/Follow Me on Social Media: https://www.instagram.com/thevoncastshow/ https://www.instagram.com/shibavon/ https://www.iamvon.net/

In this episode Dr. Gillian Beauchamp sits down with Dr. Michael Toce to discuss naloxone access laws, increased community availability of naloxone and who still doesn't have access to naloxone. They also discuss the difference between naloxone and nalmefene and the future of nalmefene. 

(The Center Square) – With few solutions left, Spokane has banned single-serve alcohol sales downtown, as well as drug paraphernalia, unless the seller also provides free naloxone. The Spokane City Council gave its final approval over two related ordinances Monday night. The first established an Alcohol Impact Area, or AIA, within the Spokane Police Department's downtown precinct, while the second created a Community Health Impact Area, also known as CHIA. Support this podcast: https://secure.anedot.com/franklin-news-foundation/ce052532-b1e4-41c4-945c-d7ce2f52c38a?source_code=xxxxxx Read More: https://www.thecentersquare.com/washington/article_d8b98560-e330-11ef-ab6d-4f32aab83dca.html

Host: Mindy McCulley, MS Family and Consumer Sciences Extension Specialist for Instructional Support, University of Kentucky  Guest: Alex Elswick, PhD Extension Specialist for Substance Use Prevention and Recovery Season 7, Episode 31 In this episode of Talking FACS, host Mindy McCulley is joined by Dr. Alex Elswick, Extension Specialist for Substance Use Prevention and Recovery, to discuss Xylazine, a non-opioid sedative increasingly found in the drug supply. Originally used in veterinary medicine, Xylazine is not intended for human consumption but is being mixed with drugs like fentanyl without users' knowledge, complicating the ongoing opioid crisis. Dr. Elswick explains the unexpected presence of Xylazine in the drug market and its implications, highlighting how it poses new risks to overdose situations. The conversation delves into the difficulties posed by Xylazine's sedative effects, which can mask opioid overdoses and complicate life-saving interventions such as Naloxone administration. The episode also explores methods used to detect Xylazine presence in communities, including innovative wastewater analysis. As the discussion unfolds, listeners gain an understanding of the broader context of drug contamination and the pressing need for enhanced public awareness. Connect with FCS Extension through any of the links below for more information about any of the topics discussed on Talking FACS. Kentucky Extension Offices UK FCS Extension           Website           Facebook           Instagram           FCS Learning Channel

Deaths from fentanyl are falling. The promising news comes as the overdose antidote naloxone becomes more widely available. But are dropping death rates concealing other issues in the fight against this brutal form of addiction? Reuters Investigative Reporter Maurice Tamman joined The Excerpt to discuss what he's seeing on the ground where addiction and death are still the reality.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Podcast summary of articles from the December 2024 edition of the Journal of Emergency Medicine from the American Academy of Emergency Medicine.  Topics include pulmonary embolism in COVID19 patients, intracranial bleeding, diltiazem in patients with heart failure, vital sign abnormalities, naloxone from the ED, and an interesting case report.  Guest speaker is Dr. Kinda Sweidan.

Nurse and university official Kathy Wilson on emergency kits now available in case of opioid overdose on campus.

As we transition into a new administration, our hosts reflect on President Biden’s legacy in healthcare policy, focusing on three major areas that impacted patients: the COVID-19 response, the opioid crisis, and the Inflation Reduction Act. They discuss key achievements such as vaccine rollouts, reduced overdose deaths, and efforts to lower prescription drug costs, while also examining ongoing challenges and concerns. With the health policy landscape set to shift in 2025, this episode breaks down what patients need to know and how to stay engaged in advocacy for better care. Among the highlights in this episode: 00:40: Steven Newmark, Chief of Policy at GHLF, outlines three key areas where the Biden administration made a significant impact in health care: COVID-19 response, the opioid crisis, and the Inflation Reduction Act (IRA) 01:28: Steven highlights the Biden administration’s mass vaccination campaign, which saved an estimated 3.2 million American lives, according to the Commonwealth Fund 01:49: Zoe Rothblatt, Director of Community Outreach at GHLF, gives credit to Operation Warp Speed under Trump for fast-tracking vaccine development but emphasizes that the bulk of vaccinations happened under Biden 02:43: Zoe reflects on how the pandemic's threat level has changed, largely due to vaccines and continued booster developments 02:58: Steven shifts the discussion to the opioid crisis, explaining that overdose deaths were rising at 31% per year when Biden took office 03:35: Steven discusses how the administration's overdose prevention efforts led to a 14.5% decrease in overdose deaths — the largest reduction in U.S. history 04:17: Zoe explains how removing barriers to Naloxone access reduces response time during an overdose emergency 04:50: Steven discusses how Biden removed an outdated waiver requirement that expanded opioid treatment access by 15 times 06:11: Steven shifts focus to the IRA, explaining that it was one of Biden’s most significant health care policies 06:27: Zoe highlights a major win: capping Medicare Part D out-of-pocket prescription costs at $2,000 per year, down from $3,500 07:29: Steven explains why this is life-changing for seniors and people with disabilities, as many rely on multiple expensive medications 08:48: Zoe discusses the $35 monthly cap on insulin prices for Medicare patients, ensuring those with diabetes have affordable access to life-saving medication 09:11: Steven explains the potential downside of IRA’s Medicare drug price negotiations, which could reduce incentives for drug companies to develop new treatments 10:32: Zoe reminds listeners that with the upcoming presidential transition, health policies could change significantly, and GHLF will continue advocating for patient needs 11:01: Steven encourages listeners to join GHLF’s 50-State Network, stay informed, and share their stories to help shape health policies. Join GHLF’s 50 State Network, share your story, and get involved in advocacy to make a difference, email us at advocacy@ghlf.org Contact Our Hosts Steven Newmark, Chief of Policy at GHLF: snewmark@ghlf.org Zoe Rothblatt, Director of Community Outreach at GHLF: zrothblatt@ghlf.org A podcast episode produced by Ben Blanc, Associate Director, Digital Production and Engagement at GHLF. We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Catch up on all our episodes on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

In this conversation, Detective Patrick Craven discusses the alarming rise of fentanyl-related deaths among youth. We highlight the role of social media in facilitating drug transactions, the risks associated with experimentation, and the deceptive nature of counterfeit pills.  Patrick emphasizes the importance of parental awareness and education regarding the dangers of drug use in today's digital age. We provide essential guidance for parents on how to communicate the dangers of these substances to their children, the importance of being informed and proactive, and the life-saving potential of Naloxone. About Detective Patrick Craven Detective Patrick Craven is employed by the Placer County Sheriff's Office. Currently, he serves as the lead detective for the Placer Opioid Response Team (PORT), a specialized unit dedicated to addressing opioid-related issues. Before his role in PORT, Detective Craven spent four years as an undercover narcotics officer for the Placer County Special Investigation Unit (PSIU). In 2020, he began investigating fentanyl poisonings and has since been the lead detective on twenty-five cases involving fentanyl deaths. Detective Craven was the lead detective on California's first fentanyl poisoning homicide conviction as well as the state's second fentanyl poisoning homicide conviction by trial. In total, Detective Craven has successfully obtained three fentanyl poisoning homicide convictions and one manslaughter conviction. Detective Craven possesses unparalleled expertise in investigating fentanyl poisoning homicides and is leading the way in this specialized field. This episode is sponsored by Bark Technologies. Learn about the Bark Phone Learn about the Bark App for iPhones and Androids  *Use code SCROLLING2DEATH FOR 10% OFF Learn about the Bark Watch 

Host: Sarah Gray Guest: Chhari Attri Air date: Jan 09, 2025

Award-winning journalists Iris St. Meran and Christie Casciano bring Syracuse, New York's biggest stories to light, covering everything from government decisions to crime. This year, however, they encountered a crisis they couldn't simply cover from the newsroom.After repeatedly hearing overdose calls on the police scanner, they felt compelled to act. In addition to anchoring a special hour-long segment on the opioid crisis, the duo took their commitment a step further by completing naloxone training. Now equipped with the life-saving skills to administer Narcan, they're ready to help someone in the grip of an overdose.In this episode of Grieving Out Loud, hear how these journalists transitioned from reporting the news to potentially responding to the opioid epidemic.If you'd like to learn how to administer Narcan, watch this video to gain life-saving knowledge and discover more about Emily's Hope's mission to distribute naloxone to those in need.Watch the full special, More Than a Number: The Opioid Epidemic in Central New York, here: https://www.localsyr.com/more-than-a-number-the-opioid-epidemic-in-central-new-york/Awareness, Action, and Hope: Navigating the Opioid/Fentanyl crisis: https://www.drugfreeisuptome.org/Learn more about Narcan here: https://emilyshope.charity/narcan/Send us a textThe Emily's Hope Substance Use Prevention Curriculum has been carefully designed to address growing concerns surrounding substance use and overdose in our communities. Our curriculum focuses on age-appropriate and evidence-based content that educates children about the risks of substance use while empowering them to make healthy choices. Support the showFor more episodes and to read Angela's blog, just go to our website, emilyshope.charityWishing you faith, hope and courage! Podcast producers: Casey Wonnenberg & Kayli Fitz

We have some information to share that could help save lives, maybe the life of someone you know. It's about reducing the harm from drug use and preventing drug overdoses. Jessica Rex is with the Safe Works Access Program of the AIDS Committee of Newfoundland and Labrador. That organization provides safe supplies for people who use drugs and also provides Naloxone kits. Jessica is the program manager for Corner Brook/Western.

Canadian journalist Nora Loreto reads the latest headlines for Monday, January 13, 2025.TRNN has partnered with Loreto to syndicate and share her daily news digest with our audience. Tune in every morning to the TRNN podcast feed to hear the latest important news stories from Canada and worldwide.Find more headlines from Nora at Sandy & Nora Talk Politics podcast feed.Help us continue producing radically independent news and in-depth analysis by following us and becoming a monthly sustainer.Sign up for our newsletterLike us on FacebookFollow us on TwitterDonate to support this podcast

Are high prices a barrier to preventing overdoses? Saliva may be the key to monitoring health. Do you feel fear? Learn More: https://radiohealthjournal.org/medical-notes-how-to-suppress-fear-why-your-saliva-matters-and-why-so-many-naloxone-prescriptions-are-unfilled Learn more about your ad choices. Visit megaphone.fm/adchoices

Finally, the journal club to rule ALL journal clubs. In this episode of The Poison Lab, we tackle one of the biggest topics in emergency medicine and toxicology: Should naloxone be given during opioid-associated cardiac arrest? With three fantastic studies published in 2024, we're diving into the data and hearing directly from the authors themselves.Join host Ryan Feldman as he interviews Dr. Eric Quinn, Dr. Joshua Lupton, and Dr. David Dillon, some of the minds behind the latest research exploring the role of naloxone in out-of-hospital cardiac arrest (OHCA). With perspectives ranging from clinical outcomes to practical implementation, this episode offers a deep dive into what these studies tell us—and what remains unanswered.But that's not all! Featuring special guests Spencer Oliver and Chris Pfingston from EMS 2020, this roundtable discussion incorporates the real-world insights of prehospital EMS professionals who face these decisions every day. Together, the panel unpacks:Conflicting evidence on naloxone's impact on ROSC and survival.The challenges of interpreting retrospective studies in a high-stakes setting.Ethical dilemmas surrounding randomized trials for naloxone.Practical considerations for paramedics and emergency physicians in the field.Whether you're a toxicologist, EMS professional, or just curious about the intersection of drugs, overdose, and resuscitation, this episode is packed with actionable insights, expert opinions, and engaging discussions.Tune in now to explore the science, controversy, and future directions for naloxone in cardiac arrest care!Studies discussed in the showOutcomes of Out-of-Hospital Cardiac Arrest Patients Who Receive Naloxone in an EMS System with a High Prevalence of Opioid Overdose – Dr. Eric Quinn.Association of Early Naloxone Use with Outcomes in Nonshockable Out-of-Hospital Cardiac Arrest – Dr. Joshua Lupton.Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrest in Northern California – Dr. David Dillon.Studies and guidelines mentioned Editorial by Dr. Lavonas on Dr. Lupton's study AHA 2023 Guidelines for poisoning cardiac arrestAHA 2021 Position statement on opioid overdose out of hospital cardiac arrest Study of opioid overdose death after bystander naloxone training mentioned by ToxoShows mentionedChris and Spencer's excellent EMS showRyan's Interview on Poisoning Cardiac Arrest Guidelines with Dr. Eric LavonasJournal club with Ryan and Dr. Dillon Timestamps and chaptersIntroduction (0:00–12:25)Podcast

Victor Shine of The Cork City Fire Brigade tells PJ they will now be able to reverse heroin overdoses the crews come across. Hosted on Acast. See acast.com/privacy for more information.

The administration of Naloxone for patients in cardiac arrest in the out-of-hospital setting has rarely been advised in the United States. Despite this, many EMS agencies allow for its administration and include the opioid antagonist in their cardiac arrest protocols. This contrast leaves the frontline EMT and paramedic with little direction on whether the drug provides a benefit to the patient suffering out-of-hospital cardiac arrest. Join us this month for the Prehospital Care Research Forum's journal club as we revive the topic and review a recent publication that compares out-of-hospital cardiac arrest patients who received Naloxone with those who did not.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822449?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=wklyforyou&utm_term=082124&adv=

Contributor: Aaron Lessen MD Educational Pearls: Can opioids cause cardiac arrest? Opioids can cause respiratory suppression and the subsequent low oxygen levels can lead to arrhythmias and eventually cardiac arrest. In 2023, 17% of out-of-hospital cardiac arrests (OHCA) were attributable to opioids. Given that this is a rising cause of cardiac arrest, should we just treat all cardiac arrest with naloxone (Narcan)? Naloxone is correlated with an increased chance of return of spontaneous circulation (ROSC) Additionally, a wide variety of individuals can be exposed to opioids and therefore opioid overdose should be considered in all cases of OHCA But does naloxone improve neurologic outcomes? Yes, naloxone, especially when given early on in the resuscitation can improve neuro outcomes What is the dose? 2-4 mg IN/IV depending on access. High suspicion for opioid overdose consider going with an even higher dose such as 4-8 mg IN/IV References Orkin, A. M., & Dezfulian, C. (2024). Recognizing the fastest growing cause of out-of-hospital cardiac arrest. Resuscitation, 198, 110206. https://doi.org/10.1016/j.resuscitation.2024.110206 Quinn, E., & Du Pont, D. (2024). Naloxone administration in out-of-hospital cardiac arrest: What's next?. Resuscitation, 201, 110307. https://doi.org/10.1016/j.resuscitation.2024.110307 Saybolt, M. D., Alter, S. M., Dos Santos, F., Calello, D. P., Rynn, K. O., Nelson, D. A., & Merlin, M. A. (2010). Naloxone in cardiac arrest with suspected opioid overdoses. Resuscitation, 81(1), 42–46. https://doi.org/10.1016/j.resuscitation.2009.09.016 Wampler D. A. (2024). Naloxone in Out-of-Hospital Cardiac Arrest-More Than Just Opioid Reversal. JAMA network open, 7(8), e2429131. https://doi.org/10.1001/jamanetworkopen.2024.29131 Summarized by Jeffrey Olson, MS3 | Edited by Meg Joyce MS1 & Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/

The Massachusetts Department of Public Health purchased 14 vending machines stocked with items like condoms, clean needles and syringes, and the overdose-reserving drug Naloxone.

Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder JAMA Network This population-based retrospective cohort study assessed whether the use of buprenorphine/naloxone is associated with lower risk of treatment discontinuation and mortality compared with methadone. It included 30,891 individuals initiating treatment for the first time during the study period and found that  the risk of treatment discontinuation was higher among recipients of buprenorphine/naloxone compared with methadone (88.8% vs 81.5% within 24 months). The risk of mortality was low while in either form of treatment (0.08% vs 0.13%).  Individuals receiving methadone had a lower risk of treatment discontinuation compared with those who received buprenorphine/naloxone. The risk of mortality while receiving treatment was similar between medications.   Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM

As emergency physicians, we are very familiar with giving naloxone to patients with concern for opioid overdose. Our EMS colleagues give naloxone all the time in the prehospital setting. We know it works well for patients who are obtained due to opioids, but what about for patients who have an out-of-hospital cardiac arrest? Our expert on todays episode, Dr. David Dillon, set out to find out.  Were you surprised by the findings in Dr. Dillon's study? Does it change your practice? Hit us up on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Associate Professor of Emergency Medicine at UC Davis Guests: David Dillon, M.D., M.Phil., Ph.D, Assistant Professor of Emergency Medicine at UC Davis Resources: Dillon DG, Montoy JCC, Nishijima DK, Niederberger S, Menegazzi JJ, Lacocque J, Rodriguez RM, Wang RC. Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrests in California. JAMA Netw Open. 2024 Aug 1;7(8):e2429154. *** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

Imagine a world where dangerous drugs are just a click away from our children. Today's guest, Carla Douglin, founder and CEO of SafeNet Solution Initiative, joins us to discuss the harsh realities of the opiate crisis and how parents can proactively protect their children. In this robust conversation, Carla shares her personal journey as a mother, her insights on the accessibility of drugs in today's world, and practical advice on talking to kids about substance abuse. We dive into topics like: - The prevalence of opioids in our communities - Effective communication strategies with children about drugs - How to address and overcome peer pressure - The importance of age-appropriate conversations around substance abuse - Essential tools like Naloxone and their role in reversing overdoses Carla's dedication to spreading awareness and educating parents is inspiring. Listen in as she shares strategies every parent needs to hear. Key Takeaways: - Understand how accessible dangerous substances are to our children. - Learn strategies to have open and honest conversations with your kids. - Discover the critical importance of tools like Naloxone. - Gain insights on teaching your children to navigate peer pressure effectively. - Get valuable resources from the SafeNet Solution Initiative on how to approach these challenging topics. Resources Mentioned: - [SafeNet Solution Initiative Website](https://snsifoundation.org) – Explore more resources and get in touch with Carla's organization. - Follow SafeNet Solution Initiative on Social Media: Instagram, Twitter, and LinkedIn.   Connect with Carla Douglin: - Website: snsifoundation.org - Social Media: @SNSIFoundation on Instagram, Twitter, and LinkedIn   Thank you for tuning in! Don't forget to rate, review, and subscribe for more episodes designed to inspire and inform. Stay safe, stay aware, and let's navigate these tricky parenting waters together.

End Overdose is a 501(c)3 non-profit organization based in California with a national reach working to end drug-related overdose deaths through education, medical intervention, and public awareness. HVDES - Music Producer, DJ, Singer/ Songwriter Supported by electronic & rock staples including deadmau5, Bring Me The Horizon, Senses Fail, Svdden Death, Kill The Noise, Of Mice & Men, and more, HVDES brings a blackhearted yet thrilling aura to the next generation of electronic & rock music. With deep roots in her local alternative & punk scenes, HVDES possesses a versatile grasp of music across the spectrum, beginning with her earliest talents as a classical pianist. Armed with her influences in the rock scene & a laptop, HVDES found her sound by expressing her authentic self—turning the darkest corners of her life into music. She offers a strikingly sinister sound that resonates on the dance floor and in the mosh pit. Much like the ruler of the underworld, the sheer intensity of HVDES' trademark sound represents her fierce persona. Stream her new album 'How to Kill A God" - https://createmusic.fm/howtokillagod Mike Giegerich - Director of Communications at End Overdose Mike Giegerich is a former music publicist with over seven years of experience working alongside a list of acclaimed artists. He has seen the effects of the opioid epidemic on both family and friends while in recovery himself. His passion for combating the overdose crisis and public relations led him to End Overdose where he now spearheads communication to the media and our growing community. To learn more visit: https://endoverdose.net/

As the opioid crisis continues to impact communities, having honest and informed conversations with our kids has never been more important. But how do you approach such a sensitive and potentially overwhelming topic? In this episode, Cindy Watson sits down with Carla Douglin, founder of the Safety Net Solutions Foundation, a nonprofit dedicated to harm reduction, and a certified opioid overdose and Naloxone trainer. Carla brings her extensive knowledge to help parents navigate one of the toughest conversations—talking to their kids about opioids.    They'll dive into practical strategies for discussing the dangers of fentanyl, the rise of fake pills, and the life-saving importance of Narcan. If you're unsure of how to approach this sensitive yet critical topic, this conversation is packed with essential tips to empower and protect your family. In this episode you will discover:   How drugs can affect a community can affect a family. The access that kids have to drugs. Why is it important for parents to discuss opioid safety with their children specially in this changing environment? Why so many parents shy away from having  this important talk with their kids? Being a learner rather than a lecturer when you're discussing drugs with kids. Using of role playing to teach kids how to handle situation. How to do it and why is it effective? Key facts about fentanyl and fake pills that every parent should communicate to their kids? Other resources or tools to learn more about opioids, safety and or how to talk to their kids about it. And many more!   Learn more about Carla:   Website: https://www.snsifoundation.org/ Instagram: https://www.instagram.com/snsifoundation/ Tiktok: https://www.tiktok.com/@snsifoundation Facebook: https://www.facebook.com/profile.php?id=61561437370726 LinkedIn: https://www.linkedin.com/company/snsifoundation/ LinkedIn: linkedin.com/in/carlaedouglin YouTube: https://youtube.com/@snsifoundation?si=pc2eUUa7YYRdJSZw   If you're looking to up-level your negotiation skills, I have everything from online to group to my signature one-on-one mastermind & VIP experiences available to help you better leverage your innate power to get more of what you want and deserve in life. Check out our website at www.artofFeminineNegotiation.com if that sounds interesting to you. Get Cindy's book here: Amazon   https://www.amazon.com/Art-Feminine-Negotiation-Boardroom-Bedroom-ebook/dp/B0B8KPCYZP?inf_contact_key=94d07c699eea186d2adfbddfef6fb9e2&inf_contact_key=013613337189d4d12be8d2bca3c26821680f8914173f9191b1c0223e68310bb1 EBook   https://www.amazon.com/Art-Feminine-Negotiation-Boardroom-Bedroom-ebook/dp/B0B8KPCYZP?inf_contact_key=94d07c699eea186d2adfbddfef6fb9e2&inf_contact_key=013613337189d4d12be8d2bca3c26821680f8914173f9191b1c0223e68310bb1 Barnes and Noble   https://www.barnesandnoble.com/w/the-art-of-feminine-negotiation-cindy-watson/1141499614?ean=9781631959776 CONNECT WITH CINDY: Website: www.womenonpurpose.ca Facebook:  https://www.facebook.com/womenonpurposecommunity/ Instagram: https://www.instagram.com/womenonpurposecoaching/ LinkedIn: linkedin.com/in/thecindywatson Show: https://www.womenonpurpose.ca/media/podcast-2/ X(Twitter):  https://twitter.com/womenonpurpose1 YouTube:https://www.youtube.com/@hersuasion Email:  cindy@womenonpurpose.ca  

The city of San Diego is expanding its two makeshift campgrounds for people experiencing homelessness, and it comes as the number of indoor shelter beds is shrinking. In other news, in San Diego life-saving medicines like Naloxone have helped reduce the number of fentanyl overdoses, but Mexico's restrictive drug policies make Naloxone almost impossible to get in Tijuana. Plus, the La Mesa Oktoberfest event manager joins the podcast with details on this weekend's festival.

In this podcast episode, Harold King, President of the Council of Industry, sits down with Deborah Smook, Co-Owner of TurboFil Packaging Machines, LLC.We dive into the world of custom packaging solutions for the pharmaceutical and medical device industries. TurboFil Packaging Machines specializes in designing and manufacturing machinery that precisely fills and packages drugs into vials, syringes, and other containers, focusing on various types of liquids and semi-solids. Deborah shares insights into their role within the broader pharmaceutical industry, highlighting their commitment to precision and safety in packaging critical medications like Naloxone, a life-saving nasal spray for opioid overdoses. We explore the engineering challenges of creating custom machines and the company's approach to innovation over its 25-year history. Deborah also discusses the evolution of TurboFil Packaging Machines from its early days in cosmetics to its current focus on pharmaceutical and medical device manufacturing, the importance of maintaining a skilled workforce, and the unique culture that drives their success. Tune in to discover how TurboFil Packaging Machines is making a difference in the packaging world and learn about the opportunities and challenges they face in this highly regulated industry.For more information about TurboFil Packaging Machines, check out their website at www.turbofil.com.--The Council of Industry has been the manufacturer's association of the Hudson Valley since 1910. We are a privately funded not-for-profit organization, whose mission is to promote the success of our member firms and their employees, and through them contribute to the success of the Hudson Valley Community. For more information about the Council of Industry visit our website at councilofindustry.org.

Date: September 18, 2024 Reference: Dillon et al. Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrests in California. JAMA Network Open. August 20, 2024 Guest Skeptic: Dr. Chris Root is an emergency medicine and emergency medicine service (EMS) physician at the University of New Mexico, Albuquerque. Before attending medical school, he was a New York […] The post SGEM#453: I Can't Go For That – No, No Narcan for Out-of-Hospital Cardiac Arrests first appeared on The Skeptics Guide to Emergency Medicine.

This is the next episode of our Push Dose Pearls miniseries with ED Clinical Pharmacist, Chris Adams. In this ongoing series we'll dig into some of the questions we all have about medications we commonly see and use in the ED. This episode focuses on naloxone. Naloxone is a staple in every ED docs toolbox but it can save more lives if it's immediately available in the community. We'll discuss ED based naloxone programs, why they are important, how to get funding, and which patients could benefit.  Do you give out naloxone in your ED? Is it readily available in your community? We'd love to hear your experience. Hit us up on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Associate Professor of Emergency Medicine at UC Davis Guests: Christopher Adams, PharmD, Emergency Department Senior Clinical Pharmacist and former Assistant Professor at UC Davis Resources: Kids Considered Podcast - Naloxone and Opioid Overdose Sindhwani MK, Friedman A, O'Donnell M, Stader D, Weiner SG. Naloxone distribution programs in the emergency department: A scoping review of the literature. J Am Coll Emerg Physicians Open. 2024 May 8;5(3):e13180. doi: 10.1002/emp2.13180. PMID: 38726467; PMCID: PMC11079430. Jacka BP, Ziobrowski HN, Lawrence A, Baird J, Wentz AE, Marshall BDL, Wightman RS, Mello MJ, Beaudoin FL, Samuels EA. Implementation and maintenance of an emergency department naloxone distribution and peer recovery specialist program. Acad Emerg Med. 2022 Mar;29(3):294-307. doi: 10.1111/acem.14409. Epub 2021 Nov 23. PMID: 34738277.. *** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

Do you give naloxone to patients who are in cardiac arrest? Should you? Can it possibly provide any benefit at all once you are already providing effective ventilations? Well, Dr. Jarvis certainly thought not. He might have even thought it out loud. Like, loudly out loud.  Based on two recent papers looking directly at this question, perhaps he needs to eat some crow and shine the bright light of science on his own damn practice. Citations:1. Strong NH, Daya MR, Neth MR, Noble M, Sahni R, Jui J, Lupton JR: The association of early naloxone use with outcomes in non-shockable out-of-hospital cardiac arrest. Resuscitation. 2024;August;201:110263.2. Dillon DG, Montoy JCC, Nishijima DK, Niederberger S, Menegazzi JJ, Lacocque J, Rodriguez RM, Wang RC: Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrests in California. JAMA Netw Open. 2024;August 1;7(8):e2429154.3. Niederberger SM, Crowe RP, Salcido DD, Menegazzi JJ: Sodium bicarbonate administration is associated with improved survival in asystolic and PEA Out-of-Hospital cardiac arrest. Resuscitation. doi: 10.1016/j.resuscitation.2022.11.007 (Epub ahead of print).4. Wampler DA: Naloxone in Out-of-Hospital Cardiac Arrest—More Than 

This week on Inside EMS, our cohosts discuss a recent study out of UC Davis Health that highlights the benefits of using naloxone in opioid-associated out-of-hospital cardiac arrest response. Chris and Kelly discuss the results and debate how this knowledge could impact OHCA protocols. Top quotes “If you look at the … survival of hospital discharge, the number needed to treat was 26. So 1 in 26 patients you would do this to has a chance of surviving the hospital discharge. That's pretty compelling. It's going to change my practice.” — Kelly Grayson “It's obviously needed information considering how bad the opioid overdose epidemic is in the United States. The numbers are compelling – the fact that this affects so many of our out-of-hospital cardiac arrests and that this actually shows pretty strong evidence of improved outcome.” — Kelly Grayson “We think about over the past 20 years, and now with fentanyl being part of that process, we're starting to see a lot more [drug-related cardiac arrests] and there's an urgent need for this evidence that allows us to now figure out if Narcan can make a difference in OHCAs.” — Chris Cebollero This episode of Inside EMS is brought to you by Lexipol, the experts in policy, training, wellness support and grants assistance for first responders and government leaders. To learn more, visit lexipol.com.

Contributor: Taylor Lynch, MD Educational Pearls: Opioid Epidemic- quick facts Drug overdoses, primarily driven by opioids, have become the leading cause of accidental death in the U.S. for individuals aged 18-45. In 2021, opioids were involved in nearly 75% of all drug overdose deaths The rise of synthetic opioids like fentanyl, which is much more potent than heroin or prescription opioids, has played a major role in the increase in overdose deaths What is Narcan AKA Naloxone? Competitive opioid antagonist. It sits on the receptor but doesn't activate it. When do we give Narcan? Respiratory rate less than 8-10 breaths per minute Should you check the pupils? An opioid overdose classically presents with pinpoint pupils BUT… Hypercapnia from bradypnea can normalize the pupils Taking other drugs at the same time like cocaine or meth can counteract the pupillary effects Basilar stroke could also cause small pupils, so don't anchor on an opioid overdose How does Narcan affect the body? Relatively safe even if the patient is not experiencing an opioid overdose. So when in doubt, give the Narcan. What if the patient is opioid naive and overdosing? Use a large dose given that this patient is unlikely to withdraw 0.4-2 mg every 3-5 minutes What if the patient is a chronic opioid user Use a smaller dose such as 0.04-0.4 mg to avoid precipitated withdrawal How fast does Narcan work? Given intravenously (IV), onset is 1-2 min Given intranasal (IN), onset is 3-4 min Given intramuscularly (IM), onset is ~6 min Duration of action is 60 mins, with a range of 20-90 minutes How does that compare to the duration of action of common opioids? Heroine lasts 60 min Fentanyl lasts 30-60 min, depending on route Carfentanyl lasts ~5 hrs Methadone lasts 12-24 hrs So we really need to be conscious about redosing How do you monitor someone treated with Narcan? Pay close attention to the end-tidal CO2 to ensure that are ventilating appropriately Be cautious with giving O2 as it might mask hypoventilation Watch the respiratory rate Give Narcan as needed Observe for at least 2-4 hours after the last Narcan dose Larger the dose, longer the observation period Who gets a drip? If they have gotten ~3 doses, time to start the drip Start at 2/3rds last effective wake-up dose Complications Flash pulm edema 0.2-3.6% complication rate Might be from the catecholamine surge from abrupt wake-up Might also be from large inspiratory effort against a partially closed glottis which creates too much negative pressure Treat with BIPAP if awake and intubation if not awake Should you give Narcan in cardiac arrest? Short answer no. During ACLS you take over breathing for the patient and that is pretty much the only way that Narcan can help Just focus on high quality CPR References https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates#:~:text=Drug%20overdose%20deaths%20involving%20prescription,of%20deaths%20declined%20to%2014%2C716. Elkattawy, S., Alyacoub, R., Ejikeme, C., Noori, M. A. M., & Remolina, C. (2021). Naloxone induced pulmonary edema. Journal of community hospital internal medicine perspectives, 11(1), 139–142. https://doi.org/10.1080/20009666.2020.1854417 van Lemmen, M., Florian, J., Li, Z., van Velzen, M., van Dorp, E., Niesters, M., Sarton, E., Olofsen, E., van der Schrier, R., Strauss, D. G., & Dahan, A. (2023). Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest. Anesthesiology, 139(3), 342–353. https://doi.org/10.1097/ALN.0000000000004622 Yousefifard, M., Vazirizadeh-Mahabadi, M. H., Neishaboori, A. M., Alavi, S. N. R., Amiri, M., Baratloo, A., & Saberian, P. (2019). Intranasal versus Intramuscular/Intravenous Naloxone for Pre-hospital Opioid Overdose: A Systematic Review and Meta-analysis. Advanced journal of emergency medicine, 4(2), e27. https://doi.org/10.22114/ajem.v0i0.279 Summarized by Jeffrey Olson MS2 | Edited by Meg Joyce & Jorge Chalit, OMSII