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For years, Hollywood executive Chris Fenton helped American studios chase the Chinese market — inserting pro-Beijing messaging into films, moving production offshore, and teaching China's own industry how to compete. Now he regrets it. Fenton joins Newt to explain how 60% of American film and TV production has moved overseas, costing Los Angeles alone more than 40,000 jobs, and why the US is the only major film-producing nation without a federal production incentive. His answer: Bad Counselors, a 100% American-made comedy — American cast, crew, and financing — shot in North Carolina, Tennessee, and California, hitting theaters nationwide July 22nd. Fenton also makes the economic case for a national film production incentive backed by a bipartisan congressional coalition, arguing that a simple 10% federal rebate could cut offshore production nearly in half and restore Hollywood's American identity.See omnystudio.com/listener for privacy information.
On this edition of The Federalist Radio Hour, film producer and author Chris Fenton joins Federalist Senior Elections Correspondent Matt Kittle to discuss how Hollywood sold out the American film industry to China, what President Trump could do to bring film jobs back to America, and why Americans need an alternative to the Silicon Valley worldview that has shaped AI.You can find tickets to Fenton's new American-made film, Bad Counselors, here.The Federalist Foundation is a nonprofit, and we depend entirely on our listeners and readers — not corporations. If you value fearless, independent journalism, please consider a tax-deductible gift today at TheFederalist.com/donate. Your support keeps us going.
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
We all create stories in our heads about what we have to do before we're allowed to succeed, be happy, or move forward. The problem? Most of those stories aren't real. In this solo episode of Operation: Be, I share one of the biggest mindset shifts I've had in years after facing overwhelming challenges in both business and life. From discovering fraud in a company I invested in, to rebuilding multiple businesses, managing an undiagnosed chronic illness, and balancing the weight of everyday life, I found myself asking a simple question: How do I get to the other side without staying trapped by my own thinking? We'll explore why our minds create invisible rules that keep us stuck, how to recognize the traps you're living in, and practical ways to refocus your energy on what actually moves your life forward. If you've been feeling overwhelmed, exhausted, or like you're carrying more than you can handle, this conversation is for you.
Why do Democrats so often lose the message war and allow Republicans to dominate the political conversation—even when Democrats and progressives have popular policies?Legendary progressive strategist and activist David Fenton says Democrats are practicing what amounts to “unilateral disarmament” in today's information war. After more than 50 years helping movements win public support, he believes progressives must simplify their language, repeat compelling messages, reconnect with working people and build mass movements capable of defeating concentrated wealth and political corruption.In this wide-ranging Lean to the Left interview, Fenton explains why good policies do not sell themselves—and why Democrats must stop relying on academic language, insider terminology and messages that ordinary voters do not understand.Fenton discusses:• Why Republicans have become better at framing political issues• How simple language and repetition influence voters• Why Democrats must speak to affordability and working-class concerns• The danger of allowing specialized identity language to divide potential allies• Why the central struggle is not simply left versus right—but top versus bottom• How Democrats should connect climate change to higher costs and political corruption• Why effective metaphors such as “Make Polluters Pay” can move public opinion• How mass movements have changed America—and can do so again• What today's activists can learn from Abbie Hoffman, the antiwar movement and decades of progressive organizingFenton also shares hilarious stories from an extraordinary career that included the No Nukes concerts, the campaign to free Nelson Mandela, efforts to reform marijuana laws, environmental campaigns and work with activists, political leaders and cultural figures including his mentor, Abbie Hoffman, and Jane Fonda, Jesse Jackson, John Lennon and Bruce Springsteen.His message is blunt: Democrats and progressives cannot win merely by being correct. They must learn how to communicate, reach a mass audience and give people a reason to join something bigger than themselves.David Fenton is the author of The Activist's Media Handbook, available here https://amzn.to/4gDYmSH, and host of The Fenton Forecast podcast.Watch the full conversation, then tell us in the comments: What is the single biggest change Democrats should make in the way they communicate with voters?Subscribe to Lean to the Left for independent progressive commentary, political analysis and conversations with the people documenting—and shaping—America at a crossroads.CHAPTERS:00:00 Meet David Fenton02:00 Dropping Out Into Activism02:46 Underground Press Days04:13 Abbie Hoffman Lessons07:37 John Sinclair Freedom Concert08:49 Ann Arbor Human Rights Party10:53 High Times To Rolling Stone11:52 No Nukes And Starting Fenton13:05 Why Progressives Lose Media Wars14:24 Framing And Simple Messages17:20 Climate Language That Works19:40 Woke Sectarianism Debate20:40 Stop Divisive Messaging22:00 Socialism Label Problem22:30 Woke Pitfalls and Attacks23:16 Plainspoken Progressives25:58 Climate as Cost and Corruption27:32 Senate Map and Party Future29:04 AOC Versus Old Guard30:37 Fixing Disinformation Platforms33:58 Trump Costs and Vance Threat37:24 Podcast Book and Farewell
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
Send us Fan MailFerroptosis, an iron-dependent cell death pathway driven by lipid peroxidation; chronoferoptosis, in which chronic stress sensitizes neurons gradually.TOPICS DISCUSSED:Cell Death Pathways: Apoptosis proceeds through regulated steps with surface “eat me” signals that enable non-inflammatory clearance by phagocytes, whereas ferroptosis and related pathways release cellular contents that can amplify local damage and inflammation.Ferroptosis Discovery: Work on glutamate toxicity in neuronal cell lines first identified a glutathione-depletion pathway termed oxytosis; parallel studies in cancer cells renamed and generalized it as ferroptosis to highlight iron's catalytic role.Lipid Peroxidation: Polyunsaturated fatty acids in membranes are oxidized non-enzymatically when ferrous iron reacts with hydrogen peroxide in the Fenton reaction, generating hydroxyl radicals that produce toxic lipid peroxides and reactive carbonyls that modify proteins.GPX4 & Glutathione: Glutathione peroxidase-4 is an enzyme that reduces lipid peroxides within membranes and requires glutathione as cofactor; depletion of either component removes this critical line of defense.Chronoferoptosis: Nine-day treatment of differentiated neuronal cells with chronic iron or glutathione synthesis inhibitor reduced GPX4 protein, raised basal lipid peroxidation, and increased cell death after addition of otherwise sublethal secondary stressors.Protective Compounds: Screening identified flavonoids such as fisetin and sterubin plus synthetic molecules J-147 and CMS-121 that block lipid peroxidation directly or indirectly and, in several cases, also raise glutathione levels.Human Disease Evidence: Postmortem brain tissue from Alzheimer's and Parkinson's patients shows elevated lipid peroxidation markers and altered iron handling in vulnerable regions; similar changes appear in animal models of multiple diseases.Dietary & NRF2 Links: Compounds that activate the NRF2 transcription factor, including sulforaphane from broccoli and certain flavonoids, upregulate antioxidant enzymes including GPX4 and may support long-term cellular resilience.ABOUT THE GUEST: Pamela Maher, PhD is a research professor at the Salk Institute for Biological Studies in La Jolla, California. Her laboratory studies ferroptosis mechanisms in neurodegenerative diseases and works to identify compounds that inhibit iron-dependent lipid peroxidation. Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
A single battery cell can shut down an entire storage plant.It's one of the many operational realities that make battery storage fundamentally different from solar, and one of the reasons software, analytics, and automation are becoming just as important as the batteries themselves.Ty Fenton, Director of Data Analytics at FlexGen, joins Nico Johnson to explore what really happens after a battery project is commissioned. From managing thousands of individual cells to processing enormous volumes of operational data, Ty explains why operating battery storage requires a completely different mindset than operating solar. They also explore how AI data centers are creating new demands for battery storage and why operators are rethinking the role batteries will play in supporting the next generation of digital infrastructure.Expect to learn:
Lorien Fenton is a longtime researcher, conference producer, and broadcaster who has become one of the most recognizable figures in the UFO and conspiracy research community. Following a life-changing near-death experience during the H1N1 outbreak in 2009, she devoted herself full-time to exploring the mysteries surrounding UFOs, government secrecy, consciousness, and unexplained phenomena. As the MUFON Marin and Sonoma Counties Meeting Director, she organizes monthly gatherings in Petaluma, California, bringing together researchers, experiencers, and investigators to share the latest developments in the field. She is also the founder and producer of the annual UFO CON in the San Francisco Bay Area, one of the premier conferences dedicated to UFOs, UAPs, and high strangeness.Beyond her work with MUFON and UFO CON, Fenton has produced dozens of conferences covering subjects ranging from UFO disclosure and mind control to time travel and the JFK assassination. She also hosts the weekly radio program The Fenton Perspective on Revolution Radio, where she interviews leading voices from across the paranormal and alternative research communities. Although she has never claimed a traditional alien abduction experience, Fenton says she witnessed her first Black Triangle UFO in 2014 and has experienced profound spiritual encounters she believes involved divine and angelic beings. With her passion for connecting researchers and encouraging open discussion, Lorien continues to be an influential voice in the search for answers about the unknown.Spaced Out Radio is your nightly source for alternative information, starting at 9pm Pacific, 12am Eastern. We broadcast LIVE every night. #UFO #UAP #AlienDisclosure #UFOSightings #UFOCoverUp #Aliens #SpacedOutRadio #Paranormal #UFOCommunity #disclosure -------------------------------------------------------You can now join the Space Traveler's Club;Join us at https://www.patreon.com/sor_space_travelers_club --------------------------------------------------------Grab Our Latest Spaced Out Radio Gear At:http://spacedoutradio.com/shop It's a great way to support our show!--------------------------------------------------------OUR LINKS:TWITTER: https://www.twitter.com/spacedoutradio FACEBOOK:https://www.facebook.com/spacedoutradioshow SPACED OUT RADIO - INSTAGRAM:https://www.instagram.com/spacedoutradioshow DAVE SCOTT - INSTAGRAM:https://www.instagram.com/davescottsor TWITCH: https://www.twitch.com/spacedoutradioshow WEBSITE: http://www.spacedoutradio.comGUEST IDEAS OR QUESTIONS FOR SOR?Contact Klaus at bookings@spacedoutradio.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/spaced-out-radio--1657874/support.
Hollywood is arguably the most recognizable brand of American movies. But in the last couple of decades, something else has increasingly dominated American domination of the movie industry: the Chinese Communist Party.How can America reclaim American-made Hollywood movies?Chris Fenton, a former Hollywood film producer of 21 films grossing a total of more than $2 billion, shares insight into the growing dilemma between Hollywood and Beijing. He is now featuring a new movie Bad Counselors that brings back American-made cinema to U.S. movie screens! Great opportunity for the whole family!www.badcounselors.comTickets on sale: June 16. Movie is released: July 22.Official Trailer YouTube: LINKDownload Vertical Trailer: LINKDownload Horizontal Trailer: LINKDownload Key Art Post: LINKX: @TheDragonFeederIG: @Feeding.The.DragonPodcast: PLATE & PONDER: Empty-Nesting w/ Jen & Chris Fenton: https://podcasts.apple.com/us/podcast/plate-ponder-empty-nesting-with-jen-chris-fenton/id1846746779 Chris's book: https://feedingthedragonbook.com/Chris's company: https://fenton-ibsc.com/Support the showVisit georgewashingtoninstitute.org to sign up for our e-mail list! The site is the one-stop shop of all things Friends & Fellow Citizens and George Washington Institute!JOIN as a Patreon supporter and receive a FREE Friends & Fellow Citizens mug at the $25 membership level!IMPORTANT NOTE/DISCLAIMER: All views expressed by the host are presented in his personal capacity and do not officially represent the views of any affiliated organizations. All views presented by guests are solely those of the interviewees themselves and may or may not represent the views of their affiliated organizations, the host, Friends & Fellow Citizens, and/or The George Washington Institute.
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
The Michigan housing market isn't one market, it's dozens of different markets.In this video, I break down five real homes I've recently listed and sold across Michigan in Mason, Fenton, Royal Oak, Westland, and Clarkston, showing exactly how differently each local market behaved.You'll see:• Why one home received 6-8 competing offers while another struggled after being relisted• Why cash offers aren't always about the highest price• What buyers should know before making an offer• The biggest mistakes sellers make before listing• How pricing strategy can create competition and drive prices higher• Why choosing the right lender can save you thousandsUsing actual MLS data, real offers, open house attendance, and real transaction outcomes, you'll see why buying or selling based solely on national headlines can cost you money.CONTACT ME
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
What if God is found as much in the ordinary as in the extraordinary? In this conversation, John Mark and Dr. Sittser take us into the days of the medieval church, highlighting the emphasis in that period on bridging the seen and unseen realms through architecture and the sacraments, showing how our faith can be enriched by the ordinary.This podcast and its episodes are paid for by The Circle, our community of monthly givers. Special thanks for this episode goes to: Vilma from Vilnius, Lithuania; Danae from Temple, Texas; Eric from Fenton, Missouri; Mark from Gig Harbor, Washington; and Devin from New Braunfels, Texas. Thank you all very much.If you'd like to pay it forward and contribute toward future resources, you can learn more at practicingtheway.org/give.
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
Tune in every Friday for more WOW Report.10) Manhattan Cable: The Clip Show That Started It All @01:479) Our Hot Doc & Flick: Party Monster @05:328) When Tom Met Randy & Fenton @09:597) The Eyes of Tammy Faye @19:136) WOWPresents & Transformations @24:265) Our Memory is Blurry: Season One of RuPaul's Drag Race @29:584) Drag Race Goes Global @38:293) Pod Save Us: Night Fever @45:442) WOWPresentsPlus: Currently Streaming & Instantly Iconic @49:271) The WOW Report Trivia: Name That Weird News Trend! @56:55
In this episode of Operation: Be, I sit down with my friend Ashley Maland for a conversation that felt both deeply personal and incredibly timely. We talk about self-worth, healing, identity, mindset, and what it means to keep moving forward when life doesn't go according to plan. Ashley shares the powerful belief she's finally embraced—that she's worthy of love, success, and belonging exactly as she is right now—and we explore how that one shift can change everything. If you've been navigating a hard season, questioning your path, or simply trying to become more aligned with who you're meant to be, I think this conversation will resonate with you. Remember: You don't have to become someone else to create a beautiful life. You just have to give yourself permission to believe that it's possible. Thanks for being here. ❤️
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
In this episode of PICU Doc on Call, hosts Dr. Monica Gray and Dr. Pradip Kamat explore procedural sedation in the pediatric ICU. They cover sedation levels, pre-screening, risk stratification using ASA classifications, and medication selection tailored to each patient's hemodynamic and respiratory status. Through real-world case discussions involving respiratory failure, septic shock, and acute neurological decline, they highlight the importance of end-tidal CO2 monitoring and early adverse event recognition. Key takeaways include avoiding the term "conscious sedation," preparing rescue plans, and prioritizing patient safety through careful assessment and monitoring.Show Highlights:Definitions and levels of sedation (minimal, moderate, deep sedation, and general anesthesia)Importance of terminology in procedural sedationMonitoring sedation levels using scales like the Richmond Agitation-Sedation Scale (RASS)Pre-screening and risk stratification considerations for pediatric patientsASA physical status classification system for assessing patient riskUnique challenges of procedural sedation in critically ill childrenAdverse events associated with pediatric procedural sedation, particularly respiratory complicationsManagement strategies for specific cases requiring sedation (e.g., respiratory failure, septic shock)Importance of end-tidal CO2 monitoring during sedationKey takeaways for safe sedation practices in the pediatric ICU settingReferences: Nir Atlas; Rahul C. Damania; Pradip P. Kamat In Fuhrman & Zimmerman - Textbook of Pediatric Critical Care Chapter 135, 1624-1628Statement on Continuum of Depth of Sedation: Definition of General Anesthesia and Levels of Sedation/Analgesia by Committee on Quality Management and Departmental Administration. Last Amended: October 23, 2024.Coté CJ, Wilson S; AMERICAN ACADEMY OF PEDIATRICS; AMERICAN ACADEMY OF PEDIATRIC DENTISTRY. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures. Pediatrics. 2019 Jun;143(6):e20191000. doi: 10.1542/peds.2019-1000. PMID: 31138666.xKrauss B, Green SM. Procedural sedation and analgesia in children. Lancet. 2006 Mar 4;367(9512):766-80. doi: 10.1016/S0140-6736(06)68230-5. PMID: 16517277.Sharif S, Kang J, Sadeghirad B, Rizvi F, Forestell B, Greer A, Hewitt M, Fernando SM, Mehta S, Eltorki M, Siemieniuk R, Duffett M, Bhatt M, Burry L, Perry JJ, Petrosoniak A, Pandharipande P, Welsford M, Rochwerg B. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials. Br J Anaesth. 2024 Mar;132(3):491-506. doi: 10.1016/j.bja.2023.11.050. Epub 2024 Jan 6. PMID: 38185564.Smith, Heidi A. B. MD, MSCI (Chair)1,2; Besunder, James B. DO, FCCM3,4; Betters, Kristina A. MD1; Johnson, Peter N. PharmD, BCPS, BCPPS, FCCM, FPPA, FASHP5,6; Srinivasan, Vijay MBBS, MD, FCCM7,8; Stormorken, Anne MD9,10; Farrington, Elizabeth PharmD, FCCM11; Golianu, Brenda MD12,13; Godshall, Aaron J. MD14; Acinelli, Larkin CPNP-AC, ACHPN15; Almgren, Christina CPNP16; Bailey, Christine H. MD17; Boyd, Jenny M. MD18,19; Cisco, Michael J. MD20; Damian, Mihaela MD, MPH21,22; deAlmeida, Mary L. MD23,24; Fehr, James MD13,25; Fenton, Kimberly E. MD, FCCM14; Gilliland, Frances DNP, CPNP-AC/PC26,27; Grant, Mary Jo C. CPNP-AC, PhD, FAAN28; Howell, Joy MD29; Ruggles, Cassandra A. PharmD, BCCCP, BCPPS30; Simone, Shari DNP31,32; Su, Felice MD21,22; Sullivan, Janice E. MD33,34; Tegtmeyer, Ken MD, FAAP, FCCM35,36; Traube, Chani MD, FCCM29; Williams, Stacey CPNP-AC37; Berkenbosch, John W. MD, FAAP, FCCM (Chair)33,34. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatric Critical Care Medicine 23(2):p e74-e110, February 2022. | DOI: 10.1097/PCC.0000000000002873Benzoni T, Agarwal A, Cascella M. Procedural Sedation. [Updated 2025 Mar 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551685/Kerson AG, DeMaria R, Mauer E, Joyce C, Gerber LM, Greenwald BM, Silver G, Traube C. Validity of the Richmond Agitation-Sedation Scale (RASS) in critically ill children. J Intensive Care. 2016 Oct 26;4:65. doi: 10.1186/s40560-016-0189-5. PMID: 27800163; PMCID: PMC5080705.Tel-Dan SF, Shavit D, Nates R, Samuel N, Shavit I. Emergency Physician-Administered Sedation for Thoracostomy in Children With Pleuropneumonia. Pediatr Emerg Care. 2021 Dec 1;37(12):e1209-e1212. doi: 10.1097/PEC.0000000000001975. PMID: 31929389.Cosgrove P, Krauss BS, Cravero JP, Fleegler EW. Predictors of Laryngospasm During 276,832 Episodes of Pediatric Procedural Sedation. Ann Emerg Med. 2022 Dec;80(6):485-496. doi: 10.1016/j.annemergmed.2022.05.002. Epub 2022 Jun 23. PMID: 35752522.Cravero JP, Blike GT, Beach M, Gallagher SM, Hertzog JH, Havidich JE, Gelman B; Pediatric Sedation Research Consortium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics. 2006 Sep;118(3):1087-96. doi: 10.1542/peds.2006-0313. PMID: 16951002.
Start your Friday with a thought-provoking and fun Free Stretch podcast. Follow Bobby on X, @bobbygameday. Bobby's podcast is an extension of his national and local radio shows. It's been at JoeBucsFan.com for 9+ years. Always a quality listen from […] The post Bobby Fenton Talks Minicamp, Baker's Contract, And The Franchise Crossroads That Is The 2026 Season On This Week's Free Stretch appeared first on JoeBucsFan.com.
An episode from Seneca Bible Baptist Church, an independent body of King James Bible believers located in Seneca Falls, New York.If you are looking for a church in the Seneca Falls, New York area that preaches the Truth from God's Word, reach out to us at any time. We would love to hear from you at (315) 568-9100 or on our website https://www.senecabiblebaptist.org/ You may also write to them at:Seneca Bible Baptist Church1859 Auburn RdSeneca Falls, New York 13148 This message is part of the KJV Bible Preaching Churches Podcast, a ministry dedicated to making faithful, King James Bible preaching available to all; especially those who may have limited access to sound biblical teaching.Our purpose is simple: to exalt the Lord Jesus Christ, uphold the authority of the Holy Scriptures, and point souls to the truth of God's Word. Every message shared through this podcast comes from likeminded, Bible-believing churches and ministries that hold firmly to the King James Bible as the final authority in faith and practice.This podcast is used as a Gospel resource and teaching tool, including outreach efforts to individuals who are incarcerated. We believe God's Word is living, powerful, and able to work in hearts wherever it is heard.If you are a pastor, preacher, or church that faithfully preaches from the King James Bible and would like to learn more about being part of this podcast, or if you have questions about this ministry, you are welcome to reach out. The KJV Bible Preaching Churches Podcast is directly supported by Doss Metrics LLC | Ministry Services based out of Cleveland Texas. If you have any questions regarding this podcast, or the churches hosted on the podcast, please reach out to us directly at dossmetrics@gmail.com or write to us at: Doss Metrics | KJV Bible Preaching Churches Podcast1451 McBride Rd.Cleveland, TX 77328 God Bless#KJVPreaching #TerryFenton #SenecaBibleBapistChurch #ChurchSermons #BiblePreaching #Churches #KingJamesBible #ChristianPodcast
Steff Fenton is a writer, speaker and pastor who spent an evening with us at Central sharing about their journey of finding a faith outside of the gender binaries, both of self and God. It was an absolute delight to listen to Steff share their story with us.
Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember
In this episode of John Solomon Reports, Alabama GOP Congressman Barry Moore joins to discuss his Senate primary runoff campaign and the key issues driving his platform. Moore also breaks down his new legislation requiring a disclaimer warning at the start of children's programming containing transgender content. In addition, he rails against the "weaponization" of the judicial system in state redistricting processes and highlights the Americans First Immigration Act, which aims to codify President Trump's executive orders. Finally, Moore stresses the critical importance of FISA reform to limit government surveillance overreach and explains the House Freedom Caucus's strong opposition to Central Bank Digital Currencies. In the second segment, Wyoming GOP Congresswoman Harriet Hageman shares updates from her own Senate campaign trail and her focus on curbing the overreach of unelected federal bureaucrats. Hageman details the SAFE Act, a bill she introduced to crack down on “chameleon carriers" – trucking companies that evade safety regulations through such means as rotating through names, ownership structures, and registration numbers to authorities, which puts unsafe drivers on the road. In the third segment, media executive, author and producer Chris Fenton dives into the shifting dynamics of Hollywood and the growing momentum toward bringing film production back to the United States. Fenton highlights his new family-friendly comedy, Bad Counselors, which was 100% American-made and employed 1,200 workers.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Contrary to historical processes, clinical trials do not have to be limited to large academic centers or homogeneous populations. On this episode, host Alex Maiersperger speaks with Dr. Mimi Fenton, CEO of Cedar Health Research, a community based clinical research organization using AI to bring trials into trusted local care settings.Drawing on her experience across academia, pharma, CROs and retail health, Dr. Fenton explains why access, education and patient support remain major barriers to participation. She discusses how Cedar embeds research into trusted community settings. The conversation also explores how AI and large language models help connect the right patients to the right trials while preserving the human relationships that drive trust and retention.
Dr. Becky Fenton started her career as a psychologist at Sing Sing Correctional Facility before being recruited to Rikers Island to supervise its psychiatric division — one of the largest and most challenging mental health systems in the country. In this episode of Locked In with Ian Bick, Becky breaks down what it was really like working inside one of America's most notorious jail systems from the other side of the cell door. She opens up about the violence and instability inside Rikers, the trauma on both sides of the system, her role in implementing Crisis Intervention Training for mental health emergencies, and what it takes to stay grounded when the environment around you is anything but. _____________________________________________ #RikersIsland #PrisonPsychology #TrueCrime _____________________________________________ Connect with Dr Becky Fenton: https://www.longislandpsychologyandconsulting.com/ Hosted, Executive Produced & Edited By Ian Bick: https://www.instagram.com/ian_bick/?hl=en https://ianbick.com/ _____________________________________________ Shop Locked In Merch: http://www.ianbick.com/shop _____________________________________________ Timestamps: 00:00 From Prison Psychologist to Private Practice — Her Story 01:48 The Early Influences and Personality That Led Her to This Work 03:37 The Education and Career Shift Nobody Expected 06:00 How She Ended Up as a Psychologist Inside Prison 08:49 Sing Sing vs Rikers Island — The Differences Nobody Talks About 11:16 Mental Health Inside Prison vs Mental Health in Hospitals — The Reality Gap 14:24 When Security and Mental Health Priorities Collide — Who Wins 18:18 Safety Violence and What It Really Takes to Advocate for Staff 20:59 How Trauma Shapes Inmate Behavior — What Most People Get Wrong 24:15 Vicarious Trauma — What Working in Prison Does to the Staff 27:15 Crisis Intervention and Deescalation — What Actually Works Behind Bars 32:33 What a Typical Day Really Looks Like Working at Rikers Island 36:31 Suicide Watch and What Inmate Care Actually Involves 39:12 Male vs Female Jails — The Shocking Differences Nobody Discusses 44:01 A Complete Day Inside Rikers Island — Hour by Hour Reality 47:20 What Destroys New Staff and How to Survive the First Year 53:01 The Truth About Solitary Confinement — What the Research Actually Shows 56:01 Rehabilitation vs Punishment — Which One Actually Works 01:00:41 Medication Management and What Happens to Inmates at Discharge 01:03:41 The Non Clinical Duties Nobody Warns You About in Federal Systems 01:06:50 How She Switched Off After Working in One of the World's Most Stressful Environments 01:10:14 The Programs and Therapy Practices That Actually Make a Difference 01:13:11 Why She Finally Left Rikers Island — The Real Reason 01:16:12 Private Practice and Why She Still Advocates for Prison Reform 01:19:01 What She Would Tell Her Younger Self — Final Thoughts _____________________________________________ To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/LockedInWithIanBicka Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dr. Becky Fenton started her career as a psychologist at Sing Sing Correctional Facility before being recruited to Rikers Island to supervise its psychiatric division — one of the largest and most challenging mental health systems in the country. In this episode of Locked In with Ian Bick, Becky breaks down what it was really like working inside one of America's most notorious jail systems from the other side of the cell door. She opens up about the violence and instability inside Rikers, the trauma on both sides of the system, her role in implementing Crisis Intervention Training for mental health emergencies, and what it takes to stay grounded when the environment around you is anything but. _____________________________________________ #RikersIsland #PrisonPsychology #TrueCrime _____________________________________________ Connect with Dr Becky Fenton: https://www.longislandpsychologyandconsulting.com/ Hosted, Executive Produced & Edited By Ian Bick: https://www.instagram.com/ian_bick/?hl=en https://ianbick.com/ _____________________________________________ Shop Locked In Merch: http://www.ianbick.com/shop _____________________________________________ Timestamps: 00:00 From Prison Psychologist to Private Practice — Her Story 01:48 The Early Influences and Personality That Led Her to This Work 03:37 The Education and Career Shift Nobody Expected 06:00 How She Ended Up as a Psychologist Inside Prison 08:49 Sing Sing vs Rikers Island — The Differences Nobody Talks About 11:16 Mental Health Inside Prison vs Mental Health in Hospitals — The Reality Gap 14:24 When Security and Mental Health Priorities Collide — Who Wins 18:18 Safety Violence and What It Really Takes to Advocate for Staff 20:59 How Trauma Shapes Inmate Behavior — What Most People Get Wrong 24:15 Vicarious Trauma — What Working in Prison Does to the Staff 27:15 Crisis Intervention and Deescalation — What Actually Works Behind Bars 32:33 What a Typical Day Really Looks Like Working at Rikers Island 36:31 Suicide Watch and What Inmate Care Actually Involves 39:12 Male vs Female Jails — The Shocking Differences Nobody Discusses 44:01 A Complete Day Inside Rikers Island — Hour by Hour Reality 47:20 What Destroys New Staff and How to Survive the First Year 53:01 The Truth About Solitary Confinement — What the Research Actually Shows 56:01 Rehabilitation vs Punishment — Which One Actually Works 01:00:41 Medication Management and What Happens to Inmates at Discharge 01:03:41 The Non Clinical Duties Nobody Warns You About in Federal Systems 01:06:50 How She Switched Off After Working in One of the World's Most Stressful Environments 01:10:14 The Programs and Therapy Practices That Actually Make a Difference 01:13:11 Why She Finally Left Rikers Island — The Real Reason 01:16:12 Private Practice and Why She Still Advocates for Prison Reform 01:19:01 What She Would Tell Her Younger Self — Final Thoughts _____________________________________________ To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/LockedInWithIanBicka Learn more about your ad choices. Visit podcastchoices.com/adchoices
It's a tale of two sprint car seasons: Brent Marks is searching for sponsors and speed after his deal with Fenton fell apart, while Aaron Reutzel can't stop winning and is pulling away in the High Limit championship.
Co-hosts Charles Love, Wilfred Reilly, Christy Kelly, and Brooks Crenshaw welcome executive producer, author, and professor Chris Fenton to discuss China's influence in U.S. industry, including film, the concept of "patriotism before capitalism," and his upcoming summer movie release Bad Counselors.Support the show
Settle in with an insightful and meaningful Free Stretch podcast. Follow Bobby on X, @bobbygameday. Bobby's podcast is an extension of his national and local radio shows. It's been at JoeBucsFan.com for 9+ years. Always a quality listen from a […] The post Bobby Fenton Talks Bucs And NFL Schedule And The Beauty That Comes With Scarcity, All On This Week's Free Stretch (Tuesday Edition) appeared first on JoeBucsFan.com.
Some seasons of life feel heavy. Not because you're failing…but because you're growing. In this episode of Operation Be, I'm talking about what it really looks like to navigate pressure, stress, and major growth as a business owner and human being…without losing yourself in the process. Over the last year, I've experienced some incredibly hard and transformative moments across my businesses and personal life, and what I've learned is this: stress can either break you, or build your capacity. We're getting into emotional intelligence, ownership, boundaries, overwhelm, and the importance of going back to basics when life feels chaotic. I'm also sharing practical tools that help me regulate stress, simplify systems, and create clarity. Because sometimes the answer isn't doing more. It's slowing down enough to recalibrate.
I've had a real urge lately to revisit the voices and careers of some of my favorite tenors. So today I bring you the exceptional American artist Charles Kullman (1903 – 1983). The early years of his career were spent primarily in Berlin and Vienna, but for twenty-five years beginning in 1935, he was also a mainstay at the Metropolitan Opera, where he sang a total of 33 different roles. The sheen and spin on his lyric voice, allied to a firm technique, allowed him sing everything from Rinuccio and Fenton to Tannhäuser and Herodes (and nearly everything else in between!) During his European years, he made a number of invaluable recordings, including opera and operetta arias as well as songs from a number of popular films in which he starred. Though he recorded only one complete operatic role in the studio (Eisenstein in Die Fledermaus in 1951), there exist a large number of choice live stage performances that allow us to more fully explore the full length (and variety) of Kullman's performing career. In this episode, we not only hear excerpts from those early German recordings, but also from live performances of Das Lied von der Erde, Meistersinger, Manon, Traviata, Fledermaus, and Montemezzi's monumental L'amore dei tre re, some of which feature recent Countermelody divas Licia Albanese, Regina Resnik, and Bidú Sayão. Some aficionado or other has dubbed Kullman “the compleat tenor” and I couldn't agree more. Enjoy getting better acquainted with this great singer! Countermelody is the podcast devoted to the glory and the power of the human voice raised in song. Singer and vocal aficionado Daniel Gundlach explores great singers of the past and present focusing in particular on those who are less well-remembered today than they should be. Daniel's lifetime in music as a professional countertenor, pianist, vocal coach, voice teacher, and author yields an exciting array of anecdotes, impressions, and “inside stories.” At Countermelody's core is the celebration of great singers of all stripes, their instruments, and the connection they make to the words they sing. By clicking on the following link (https://linktr.ee/CountermelodyPodcast) you can find the dedicated Countermelody website which contains additional content including artist photos and episode setlists. The link will also take you to Countermelody's Patreon page, where you can pledge your monthly or yearly support at whatever level you can afford.
In this podcast, Greg Voisen sits down with Dr. Stephen Fenton, author of The 5 CH Lifestyle: Lower Your Cholesterol Without Medication, Reduce Your Risk of Heart Attack and Achieve Long-term Wellness, to reveal why traditional medicine often misses the silent warning signs of heart disease. Dr. Fenton explains how the "Five CHs"—Chops, Cheese, Chips, Chicken Skin, and Chocolate—contribute to plaque buildup and why a simple CAC heart scan is more effective than standard risk calculators. Listeners will learn how to identify hidden risks, use the "Miserable Month" challenge to slash cholesterol, and adopt a holistic "Chill, Chat, and Chuckle" lifestyle to potentially reverse arterial damage and achieve lasting health.
Let's clear something up… You're not overwhelmed. You're overextended. In this episode of Operation Be, I'm breaking down the difference, and why it matters more than you think. Because what feels like anxiety…chaos…even excitement sometimes? Is often just you trying to do more than your time and capacity can actually hold. We're getting into how to spot overextension before it turns into burnout, why slowing down is the fastest way to get back in control, and the real reason your schedule feels impossible (hint: you're not accounting for life in between). Trust me…getting back on track doesn't happen overnight. It happens when you recalibrate with intention.
Let's talk about something that doesn't get named enough…but affects everything: Emotional load. And no, it's not just “being emotional.” In this episode of Operation Be, I'm breaking down what emotional load actually looks like in real life: the constant mental tabs, the anticipating, the remembering, the invisible weight that so many people (especially women) carry every single day. From my own marriage to business partnerships, I've seen how this shows up:
By now, I have done over a hundred interviews but every one is still special to me. But ones like this are why I do what I do. I met Jimmy Gaspero through talking and writing comics online. Jimmy's unique critical view was one that I fell in love with the first time I read it. Since then, I have had Jimmy as a writer on my site for awhile and now he's helping lead the charge over at Comic Book Yeti. There is a level of love and heart he brings to everything he does from his own work to being a dad to being just a pillar of the comics community. Not only that, but Jimmy's wife is photographing my wedding; Jimmy is a brother to me. I have had the pleasure of watching him start his comics career and grow into a published author of this status. His anthology Made in Delco is a love letter to the area we both hold close to our hearts. Jimmy is a writer who you want to keep an eye on because his future is so bright. That is why I was so excited to get the chance to read his first full published graphic novel Penny and the Yeti from Papercutz (A Mad Cave Imprint). Penny and the Yeti is written by Jimmy, art by Amber Akin, and letters by Buddy Beaudoin. In our conversation, we discussed the novel and how it handles adult themes in a way that helps children navigate them on their own. Penny and the Yeti is a beautiful story of family, friendship, and the struggles of working through unpleasant feelings. I highly suggest it to any parent or child who is looking for a wonderful journey with a cryptid. YETI OR NOT, HERE WE COME! Penny and Yeti are pretty typical best friends: they go to school together, play together, and have fun adventures. The twist? Yeti's a living breathing myth! Before Yeti, Penny had a super normal life with her big sister Peri and their parents, Fenton and Maxine. Penny thinks life is pretty great, especially when Peri draws and colors with her—Peri draws the best monsters called "cryptids!" The only real problem is that Penny's parents argue… a LOT. Penny wishes her parents would stop, but what can she do? That's when Yeti shows up, right out of one of Peri's drawings and smack into Penny's life! With Yeti's help, Penny comes up with a plan to get her parents to stop fighting. Penny, however, soon finds out that her parents may need more help than even a magical Yeti can provide…
In this powerful 1-on-1 interview from the 2026 Live Unreal Summit in Phoenix, Jeff Glover sits down with top-producing real estate agent and team leader Jennifer Skulley to break down the mindset, systems, and culture behind her explosive growth. With over 22 years in the real estate industry, Jennifer leads a high-performing team at the Glover Agency out of Fenton, Michigan. Her results speak for themselves—growing from 78 units and $21.6M in 2024 to an impressive 145 units and $47.5M in 2025. In this conversation, Jennifer shares: The key drivers behind her team's rapid growth and success How she built a culture agents genuinely want to be part of Her transition from solo producer to successful team leader The strategies she used to recruit, train, and scale her team The importance of community and the unique ways her team connects in Fenton Jennifer also opens up about the personal challenges that shaped her journey—including the loss of her son and going through a divorce—and how she found the strength to keep moving forward, one step at a time. This is more than a real estate interview—it's a masterclass in leadership, resilience, and building a business that lasts.
Let's talk about something that looks like support…but often creates more stress. In this episode of Operation Be, I'm unpacking a dynamic I've experienced too often: sharing that I'm overwhelmed, only to have people start deciding for me what I can and can't handle. Information gets withheld. Tasks get delayed. People try to “protect” my time…without asking. And that's not support. That's misalignment. I'm talking about why this creates confusion, missed deadlines, and unnecessary emotional labor (especially for women in leadership) and the difference between asking for help and simply being transparent. We'll get into what real support actually looks like: clear roles, honest communication, and truth shared with respect. Because honesty isn't being harsh. And avoiding truth doesn't help anyone move forward.
We are flipping the script and doing something new today to celebrate our 450th episode as I welcome my co-host Jimmy Gaspero on for the very first time as a guest of the show to celebrate the release of his debut graphic novel project Penny and the Yeti from Papercutz. I've known about some of the origin story of the project but not all of it that started as a simple bedtime conversation with his daughter, Penny, and somehow became a fully-fledged graphic novel with artist Amber Akin. We do a deep dive into that transition, the relatable real life parental struggles woven into the fabric of the story, and Jimmy shares some of his all-time favorites from cryptids to plays. Jimmy on BlueSky Buy Penny and the Yeti From the publisher YETI OR NOT, HERE WE COME! Penny and Yeti are pretty typical best friends: they go to school together, play together, and have fun adventures. The twist? Yeti's a living breathing myth! Before Yeti, Penny had a super normal life with her big sister Peri and their parents, Fenton and Maxine. Penny thinks life is pretty great, especially when Peri draws and colors with her—Peri draws the best monsters called “cryptids!” The only real problem is Penny's parents argue…a LOT. Penny wishes her parents would stop, but what can she do? That's when Yeti shows up, right out of one of Peri's drawings and smack into Penny's life! With Yeti's help, Penny comes up with a plan to get her parents to stop fighting. Penny, however, soon finds out that her parents may need more help than even a magical Yeti can provide… Follow Comic Book Yeti
Utility-scale batteries are far more complex than they appear. Ty Fenton, Director of Data Analytics at FlexGen, breaks down how software keeps massive battery systems running — from detecting a single failing cell among thousands to predictive diagnostics powered by machine learning. The episode dives into real-world degradation versus lab data, operators who intentionally voided warranties for short-term profit, and why AI training loads create extreme power spikes that only batteries can absorb. Recorded live at Intersolar San Diego. Topics Covered: FlexGen = Flexible Generation Battery Management Battery Technology Software Point of Interconnection Energy Storage Systems Warranty Terms Battery Manufacturer Lithium-Ion Batteries Data Centers Training Load Profile Machine Learning Accelerated Aging Reach out to Ty Fenton here: LinkedIn: www.linkedin.com/in/ty-fenton-84782830/ Website: www.flexgen.com Learn more at www.solarSEAN.com and be sure to get NABCEP certified by taking Sean's classes at www.heatspring.com/sean www.solarsean.com/pvace
If you've ever been told to “pick one thing” or “niche down,” this episode is for you. In this episode, I open up about being labeled a “serial entrepreneur” and the pressure that comes with it. After investing in a $10,000 program that pushed me into a business model that didn't fit, I realized something important: ✨ The problem wasn't my ambition. ✨ The problem was when I stopped trusting myself. I share why being multi-passionate doesn't mean you're scattered—the common denominator in everything you build is you. And when you're grounded in clarity, building multiple things can actually be your strength. We'll talk about: Why niching down isn't always the answer The difference between distraction and intentional growth Why structure and support matter more than discipline If you've been questioning your path, consider this your reminder: You're not too much—you're just not meant to build small.
(00:00-18:00) Cam would dance around in a leprechaun costume. Martin's in Daytona. Wouldn't wanna date Cam's daughter. What sport would Cam prefer his hypothetical daughter date? Texting and driving. Wrestlemania. Larry Nickel is on the phone lines to confirm that wresting is real. Recapping us on last night's Raw.(18:08-42:50) Fenton is the Vegas of the midwest. Some audio from Spittin' Chiclets talking about the pressure on young kids in youth hockey these days. Parents treat the kids like superstars and celebrities at a young age these days. Youth sports discussion.(42:58-1:06:03) David Cline of Hedonism's version was better. Dancing and karaoke died with Chairman's sobriety. Can the price of youth hockey come down? Team sports teaching more than just athletic skill. Doug thinks there's plenty of NBA players who could be playing in the NFL. Cam wishes he woulda been a quarterback. Kellen Winslow. Best athlete to come out of St. Louis. Yogi Berra was Cam's shower partner. Oblong/Abnormal.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.