Podcasts about ameliorate

I'm going to take you somewhere today, to one main and clear message with only about 4 words in it, which answers the question of what to do when you feel powerless to help.  And I'm going to give you three concrete things to do that fall under this 4 word umbrella.  But per usual, I'm going to take you there via a series of true stories—which I believe all still add up to the same equation: the answer to feeling powerless and wanting to help.  So if you've felt powerless to help, if you see suffering and don't know what to do about it—I hope you join me on today's podcast ride.  I hope it lights a candle in your heart.SHOW NOTES:Happy New Year Freebies:FREE DOWNLOAD: Get the beginning part of my book, Getting Answers: Using Your Intuition to Discover Your Best Life, for free.FREE DOWNLOAD: “How to tell the difference between the voice of your intuition and your ‘fear-based' ideas.”I want to dive deeper into my own magic and inner wisdom.  I want to Own My Intuition!! Tell me all the details of your program!Download Aimée's free: “44 Signs You Are An Empath.” (Also includes “4 Antidotes to Common Empath Challenges:” audio) I want Empath Core Tools! For more about Aimée, her work, readings, speaking, or classes visit www.AimeeCartier.com.  Aimée on InstagramAimée on FacebookAimée on TikTok

SELECTED LINKS FROM THE EPISODETeach Your Kids: Website | LinkedIn | X | Instagram | Substack | Facebook | TikTokManisha: LinkedIn | X | Instagram | FacebookJoin our premium community with expert support and adviceTeach Your Kids Curriculum Planner General Curriculum ResourcesTeach Your Kids Curriculum PlannerThe Complete Guide to Secular Homeschool Curriculum50 Educational Apps Your Kids Will LoveMastery Hours: Core Subjects for Your Power HoursHow to afford homeschooling What's a typical homeschool day look like?Giving kids the time and space they need to teach themselves  Special NeedsCognitive Diversity and homeschooling All-in-One CurriculumThe top 12 all-in-one secular homeschool curricula of 2023Khan Academy Critical thinking CoTime4LearningBuild Your LibraryTorchlightBlossom & RootEarly YearsKindergarten1st Grade2nd Grade3rd Grade4th Grade5th GradeMath The Best PreK-12th Grade Math Curriculum of 2023RightStart MathAn honest review of Right Start Math (this guide can help you navigate Right Start Math as it can be a bit tricky)There's No Such Thing as Not a Math Person with Rachel Thomas, P.H.DTeach Your Kids: Game-Based Learning: The Prodigy Approach with Rohan Mahimker Teach Your Kids: Navigating Math with Curiosity: Jason Batterson & Jasmine Eyal on Beast AcademyManisha's Interview with Richard Rusczyk (Co-founder of Beast Academy and AoPS)Beast Academy OnlineBeast Academy Comic BooksSingapore MathThinkwellWild MathProdigy Game LiteracyThe top 4 tools to teach your child to read in 2023NessyHomerTeach Your Child to Read in 100 Easy Lessons English Language ArtsEnglish Language Arts Nurturing Critical Thinkers Teach your kiddo to writeThe Ultimate Guide to Handwriting Curriculum in 2023Does grammar matter?Ameliorate your progeny's lexiconPublic Speaking for Kids Youtube ChannelsArt for Kids Hub - YouTubeCosmic Kids Yoga - YouTube  Assessments & Evaluating ProgressIs your child on track?Map Growth | Homeschool BossMobyMax for Families OtherOur six favorite environmental science programs for kids (and grownups) in 2023.Teaching Kids Financial Literacy in the Age of SVB Non-profits offering free or discounted internet and devicesGive ComputersAFTRRSpectrum Internet Assist Program Related Teach Your Kids Podcast EpisodesRaising Indistractable Kids: Nir Eyal's Unconventional Approach to HomeschoolingRachel Thomas Unpacks Homeschooling: A Deep Dive into Screen Time, Apps, and Data EthicsBack to Homeschool: With the Founder of Secular Eclectic Academic (SEA) Homeschoolers - Blair LeeRaising Gifted Learners With Megan Cannella: Insights From a Gifted Learning Specialist About Identifying and Supporting Gifted KidsJeremy Howard's Journey: From Traditional Schools to HomeschoolingMiscellaneousSEA Homeschoolers FacebookWild LearningA nematode survived 46,000 years in permafrost : NPRHow to find and vet the best homeschool teachers This site contains product affiliate links. We may receive a commission if you make a purchase after clicking on one of these links. Time-Codes00:00:00 — Introduction: Manisha Snoyer dives into the art of customizing children's education.00:01:21 — The Two Pillars: Importance of a main curriculum and a math supplement.00:03:57 — Keeping Kids Engaged: Manisha advocates for fun, interactive curricula.00:06:44 — Quality Control: Testing curricula for accuracy and reliability.00:08:08 — Universe Explored: The beauty of curiosity and scientific understanding.00:10:46 — Inclusive Learning: Manisha talks about diversifying history and literature materials.00:14:30 — A Cautionary Note: Manisha warns against curriculum biases.00:17:00 — Urgency underlined: The importance of teaching climate change.00:23:37 — Learning Disabilities: How multiple disabilities affect curriculum choice.00:26:22 — Game On!: The role of video games in curriculum selection.00:29:46 — Empowering Parents: Trusting your instincts for your child's educational needs.00:32:20 — Frugal Tips: Manisha offers ways to afford homeschooling.00:37:00 — Fundamental Focus: The emphasis on math and literacy.00:40:27 — Self-Directed Learning: Incorporating child-led education into the schedule.00:49:00 — DIY Curriculum: How to create a tailored learning plan from various resources.This podcast is made possible through a generous grant from the Vela Education FundVELA Education Fund is catalyzing a vibrant alternative education ecosystem. VELA provides trust-based funding to entrepreneurs, fosters community-building and knowledge-sharing, and increases visibility through storytelling that promotes cultural awareness and acceptance of the out-of-system space. Today, VELA serves the largest community of out-of-system education entrepreneurs in the country, with over 2,000 community members. About half of VELA's community members operate small learning environments, and the other half are ecosystem and community builders offering direct services and support across the out-of-system space. Learn more at velaedfund.org.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551394v1?rss=1 Authors: Fernandez-Gonzalez, A., Mukhia, A., Nadkarni, J., Willis, G., Reis, M., Zhumka, K., Vitali, S., Liu, X., Galls, A., Mitsialis, S. A., Kourembanas, S. Abstract: Objective: Macrophages play a central role in the onset and progression of vascular disease in pulmonary hypertension (PH) and cell-based immunotherapies aimed at treating vascular remodeling are lacking. This work evaluates the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/pro-resolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced PH. Approach and Results: Mouse bone marrow derived macrophages (BMDMs) were polarized in vitro to a regulatory (M2reg) phenotype. M2reg profile and anti-inflammatory capacity were assessed in vitro upon lipopolysaccharide (LPS)/interferon-{gamma} (IFN{gamma}) restimulation, before their administration to 8- to 12- week-old mice. M2reg protective effect was tested at early (2 to 4 days) and late (4 weeks) time points during hypoxia (8.5% O2) exposure. Levels of inflammatory markers were quantified in alveolar macrophages and whole lung, while PH development was ascertained by right ventricular systolic pressure (RSVP) and right ventricular hypertrophy (RVH) measurements. Bronchoalveolar lavage (BAL) from M2reg-transplanted hypoxic mice was collected, and its inflammatory potential tested on naive BMDMs. M2reg macrophages demonstrated a stable anti-inflammatory phenotype upon a subsequent pro-inflammatory stimulus by maintaining the expression of specific anti-inflammatory markers (Tgf{beta}, Il10 and Cd206) and downregulating the induction of proinflammatory cytokines and surface molecules (Cd86, Il6 and Tnf). A single dose of M2regs attenuated the hypoxic monocytic recruitment and perivascular inflammation. Early hypoxic lung and alveolar macrophage inflammation leading to PH development was significantly reduced and, importantly, M2regs attenuated RVH, RVSP and vascular remodeling at 4 weeks post treatment. Conclusion: Adoptive transfer of M2regs halts the recruitment of monocytes and modifies the hypoxic lung microenvironment, potentially changing the immunoreactivity of recruited macrophages and restoring normal immune functionality of the lung. These findings provide new mechanistic insights on the diverse role of macrophage phenotype on lung vascular homeostasis that can be explored as novel therapeutic targets. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Merriam-Webster's Word of the Day for July 21, 2023 is: ameliorate • uh-MEE-lee-uh-rayt • verb Ameliorate is a formal word that means "to make something, such as a problem, better or more tolerable." // The council is reviewing a plan that aims to ameliorate the town's affordable housing crisis. See the entry > Examples: "With many institutions embracing diversified forms of student enrollment, we believe that colleges and universities must be able to evaluate the experiences of all their students if they are going to truly embrace equity. To achieve this, leaders must ... strategically act to ameliorate any differences across student groups. While this might seem ... obvious, our research revealed that not many colleges are presently engaging in such comparisons." — Joshua Travis Brown and Joseph M. Kush, Inside Higher Ed, 15 June 2023 Did you know? Ameliorate traces back to melior, a Latin adjective meaning "better," and is a rather formal synonym of the verbs better and improve. When is it better to use ameliorate? Allow us to improve your understanding: if a situation is bad, ameliorate indicates that the conditions have been made more tolerable. Thus, one might refer to medicine that ameliorates pain from an injury, a loss of wages ameliorated by unemployment benefits, or a harsh law ameliorated by special exceptions. Improve and better apply when something bad is getting better or being made better (as in "the weather improved" or "she bettered her lot in life"), and they should always be chosen over ameliorate when something good is getting better still ("he improved his successful program," "she bettered her impressive scores").

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535354v1?rss=1 Authors: Tai, Y.-H., Engels, D., Locatelli, G., Fecher, C., Theodorou, D., Mueller, S. A., Licht-Mayer, S., Kreutzfeldt, M., Wagner, I., Emmanouilidis, I., Gkotzamani, S.-N., Trovo, L., Kendirli, A., Aljovic, A., Breckwoldt, M. O., Naumann, R., Bareyre, F. M., Mahad, D., Merkler, D., Lichtenthaler, S. F., Kerschensteiner, M., Misgeld, T. Abstract: Inflammation in the central nervous system (CNS) can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how inflammation alters the molecular composition and functional capacity of neuronal mitochondria. We show that neuroinflammatory lesions in the mouse spinal cord cause widespread and persisting axonal ATP deficiency, which precedes mitochondrial oxidation and calcium overload. This axonal energy deficiency is associated with impaired electron transport chain function, but also an upstream imbalance of tricarboxylic acid (TCA) cycle enzymes. Among these, isocitrate dehydrogenase 3 (Idh3), a rate-limiting enzyme of the TCA cycle, is depleted in neuronal mitochondria in experimental models and in MS lesions. Notably, viral overexpression of an Idh3 subunit ameliorates the axonal energy deficits in neuroinflammatory lesions, suggesting that TCA cycle dysfunction in MS may be amendable to therapy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Велин Вълчев за новия сингъл на BLACK:I „Ultuula Zikru Sagkal“ на Радио Варна , излъчен пряко в „От другата страна“ на 13 март. В предаването ще звучи музика на: SCOTOPIA, AMELIORATE, DEVILDRIVER, REDEMPTION, MINENWERFER и др.

От другата страна представя проекта AMELIORATE и миниалбума „Demons“ – разговор Борислав Захариев

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.12.528218v1?rss=1 Authors: Li, A., Yi, J., Li, X., Dong, L., Ostrow, L. W., Ma, J., Zhou, J. Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease that affects all voluntary muscles in the body, leading to paralysis and respiratory failure, while the extraocular muscles (EOMs) are largely spared even at the end-stage of ALS. Through whole-mount muscle imaging, we detected severe denervation along with depletion of Pax7+ satellite cells (SCs) peri-neuromuscular junction (NMJ) in hindlimb and diaphragm muscles of end-stage SOD1G93A mice (a familial ALS mouse model), but not in EOMs. Upon isolating SCs from different muscles using fluorescence activated cell sorting (FACS), the FACS profiles of hindlimb and diaphragm SCs of G93A mice exhibited activation and depletion phenotypes but not in wildtype controls. Importantly, both wildtype and G93A EOM SCs exhibited spontaneous activation behavior without significant differences in abundance. Examination of Pax7+ and Ki67+ cell ratios and RNA-Seq of SCs cultured in growth and differentiation medium revealed that EOM SCs maintained renewability and stemness better than diaphragm and hindlimb counterparts, especially in differentiation-favoring environments. Comparative functional annotation analyses indicate enrichment of axon guidance molecules, such as Cxcl12, in cultured EOM SCs. In neuromuscular coculture experiments, overexpressing Cxcl12 in G93A hindlimb SC-derived myotubes enhanced motor neuron axon extension and improved innervation, partially replicating the multi-innervation property of EOM SC-derived myotubes. The unique SC homeostasis regulation and the production of axon guidance molecules including Cxcl12 may explain the ALS resistant nature of EOMs. Intriguingly, feeding G93A mice with sodium butyrate extended the life span of G93A mice, alleviated NMJ denervation and SCs depletion. Butyrate treatment promoted renewability and stemness of cultured G93A hindlimb and diaphragm SCs, as well as Cxcl12 expression. Thus, butyrate-induced EOM SC-like transcriptomic patterns may contribute to its beneficiary effects observed in G93A mice. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

How To Improve Age Reversal, Increase Longevity, Improve Sleep Analytics, and Improve Memory Care with Andrew Saltman and Profusion

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.06.522988v1?rss=1 Authors: Kassouf, T., Shrivastava, R., Meszka, I., Bailly, A., Polanowska, J., Trauchessec, H., Mandrioli, J., Carra, S., Xirodimas, D. Abstract: In Amyotrophic Lateral Sclerosis (ALS) motor neuron disease, mutations in proteins that upon stress localize within cytoplasmic protein inclusions called Stress Granules (SGs), are linked to the formation of aberrant inclusions, which are related to neuronal cell death. By combining studies in human cells and C. elegans including the use of Nanobodies, we found that inhibition of NEDP1, the enzyme responsible for the processing and deconjugation of the Ubiquitin-like molecule NEDD8 from substrates, promotes the elimination both of physiological and pathological SGs. The hyper-NEDDylation of Poly-(ADP-ribose) polymerase-1 enzyme upon NEDP1 inhibition compromises PAR production and is a key mechanism for the observed SG phenotype. Importantly, the above-described effects are related to improved cell survival in human cells, and in C. elegans, NEDP1 deletion ameliorates ALS-phenotypes related to animal motility. Our studies reveal NEDP1 as potential therapeutic target for ALS, based on the elimination of aberrant SGs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dear all, I wish everyone a wonderful New Year's Eve and a powerful start into 2023! May this year encourage you to take greater responsibility for your health first and foremost, may you come to the realization that you are literally the only one who must take it into your own hands. By that same token, I hope that this special episode I had with Dr. Sean O'Mara will be of some value in guiding you on your journey towards a healthier life. We discussed his work in depth and touched on some of the explanations on why particularly visceral adipose fat seems to be so ruthlessly associated with chronic disease of any kind, insulin resistance and heart disease being the most crucial ones nowadays. Enjoy listening to this episode on Sapien's Playground where I continue to learn from the greatest, extract wisdom from those who are wiser than me. Accept your ignorance, open your mind to become amenable to growth and always assume that the person you are talking and listening to might tell you something you don't know yet. I wish a blessed 2023 to you and your families! Find Dr. Sean O'Mara on Insta: https://www.instagram.com/drseanomara/ Dr. Sean O'Mara's Webpage: https://drseanomara.com/ Find me on Instagram: https://www.instagram.com/maximpruchnewski/ Find me on Twitter: https://twitter.com/MPruchnewski More free stuff (books, videos and PDFs): https://linktr.ee/sapien_health Sapiens Playground on YouTube: https://www.youtube.com/channel/UCmNDo81K7jX7Thk0_NF_xng Listen to Sapiens Playground on Spotify: https://open.spotify.com/show/6IcilHhRDVTiVxGO5uuYlp?si=ab520e5d7fc24a3a Listen on Apple Podcasts: https://podcasts.apple.com/de/podcast/sapiens-playground-a-place-for-true-health-unbiased/id1534777361 You can text me at sapiens.playground@web.de for podcast inquiries or any questions you have.

(v.) to make or become better, more bearable, or more satisfactory

How can one ameliorate their circumstances? The crew discusses on BIG FACTS FRIDAY. Visit: www.bigfactspod.com | For Merch: bigfactsmerch.myshopify.com | Follow: @BigFactsPod See omnystudio.com/listener for privacy information.

How does your learning technology leverage your spatial cognitive ability to lead learners effectively? Problems surrounding spatial ability with regard to learning performance have been the focus of many learning technology debates over the years. However, the conversation is almost exclusively centered around the learner with little attention given to leaders and instructors. There is an underlying expectation for leaders to inherently understand and be proficient with the tech that we are provided with. Spatial ability needs to be a two-way street for both the instructor and learner to provide sustainable learning in the #futurowork. In this Learning Tech Talks, I'm excited to meet with Chris Olson from Class to hear more about some of the concerns and solutions for instructors as they seek to change the way the world learns and address some of the remaining band-aids from the pandemic and how to leverage existing tools to meet the needs of both the instructor and learner effectively and efficiently. --- Support this podcast: https://anchor.fm/learningtechtalks/support

Professor Tim Evans of Middlesex University looks at the shocking growth in NHS waiting lists and wonders if providing tax breaks on private health provision for the elderly might prove a helpful way forward. He also considers the crisis in policing, suggesting a possible solution, even though few politicians might be willing to think long enough ahead. And he ends on an optimistic note, hoping that the recent breakthrough at JET might herald a coming age of nuclear fusion. Learn more about your ad choices. Visit megaphone.fm/adchoices

Happy 2022! We're back for Season 2 of There is a Better Podcast. Guesty is out today, so it leaves Tony and Ghosty. Ghosty can't wait to reveal his new name. Today's episode is brought to you by the word: Ameliorate. We talk about why Guesty is out for the day. There is a Better Recommendation: Calm App, or Headspace App. We discuss Top Ten New Year's Resolutions, and Grandma Chimney. We pay tribute to those who we lost between the last show and this show. One of them would have had a birthday today. Find us on Twitter and Instagram. Also email us: thereisabetterpodcast@gmail.com. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Ameliorate means to make something bad or unsatisfactory better. This episode embodies the definition of the word. This anonymous discussion covers all the bases of mental illness and crisis. Suicide, control, narcissistic and depressive disorders.  This ‘thrival story is another in our special September Suicide Awareness Inner-Views.  The boys get a lesson on the Stamford Prison experiment, the Lucifer Effect and just how much damage the human condition has endured. Sometimes we are left to just have to figure it all out on our own for ourselves and no one else. Don't be discouraged if today is tough, the Day After Tomorrow, it may get better.  Thanks for listening and making AGP part of your life. Please follow, fan, friend, scribe, share, and like us on all our platforms: https://abovegroundpodcast.net   https://www.youtube.com/channel/UCKn_Suc7apr3VIO1iX65cBg?app=desktop   https://www.facebook.com/abovegroundpodcast   https://twitter.com/abovegroundpod   https://www.instagram.com/abovegroundpodcast/   https://www.paypal.com/paypalme/abovegroundpodcast   https://podcasts.apple.com/us/podcast/above-ground-podcast/id1476950544   https://open.spotify.com/show/7ogZ00r2sYwC0unlEwcJ5w?si=-ioYxi_dSiuDMLOV_x9qFg&dl_branch=1   https://podcasts.google.com/feed/   https://castbox.fm/channel/Above-Ground-Podcast-id2561617?country=us   https://www.audible.com/pd/Above-Ground-Podcast-Podcast/B08K564DM3

SIS talk is back : April is financial awareness month and also Sexual assault & Child Abuse Awareness month. We both believe that both topics are needed to improve our communities and individual families. We cannot heal or break generational curses without having these conversations. Although they can be tough or seem unnecessary they are worth the difficult emotions and breakable barriers. With that said , Be on the look out for our May episodes that will be dropping soon as well. Give us feedback . Happy Financial Literacy Month and Sexual Assault Awareness month . Hope these episodes instill change even if in one individual

Nick Grono is an Australian (ex-pat) human rights campaigner who heads the Freedom Fund in London – the world's first private donor fund dedicated to ending slavery. Nick speaks with Michelle Michels about the work 'The Freedom Fund' is doing throughout modern slavery affected countries to assist in reducing the incidence of human trafficking into modern slavery. Nick is also the co-chair of the Jo Cox Foundation, and a board member of Girls Not Brides, the Global Partnership to End Child Marriage. Nick was the inaugural CEO of the Walk Free Foundation, a leading international actor in the fight against modern slavery. Prior to this, Nick was the Deputy President and COO of the International Crisis Group (ICG), the world’s leading conflict prevention NGO. Nick has testified on conflict and human rights issues before the European, UK, Dutch, and Australian Parliaments.

I need your help! I have a new book that I am working on and I need your help in Pre-ordering the book! This pre-order period only last for 30 days. My goal is to get 1000 pre-orders so I can connect with a big publisher who will take care of the upfront cost! Pre-Order Here: https://publishizer.com/motivate-elevate-and-ameliorate

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.08.331256v1?rss=1 Authors: Higurashi, S., Tsukada, S., Nakano, S., Mori, I., Noma, K. Abstract: Diet is proposed to affect brain aging. However, the causality and mechanism of dietary effects on brain aging are still unclear due to the long time scales of aging. The nematode Caenorhabditis elegans (C. elegans) has led aging research because of its short lifespan and easy genetic manipulation. When fed the standard laboratory diet, Escherichia coli (E. coli), C. elegans experiences an age-dependent decline in temperature-food associative learning, called thermotaxis. To address if diet ameliorates this decline, we screened 35 different lactic acid bacteria as alternative diets. We found that Lactobacilli in a clade enriched with heterofermentative bacteria ameliorated age-dependent decline. On the other hand, homofermentative Lactobacillus species did not show this beneficial effect. Lactobacilli affected the thermotaxis of aged animals through DAF-16, an ortholog of mammalian FOXO transcription factor, while the effect on the thermotaxis was independent of the lifespan and locomotion. Our results demonstrate that diet can impact brain aging without changing the lifespan and that bacterial screen using C. elegans is a powerful approach to investigate age-dependent behavioral decline. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.01.322115v1?rss=1 Authors: Peelaerts, W., Bergkvist, L., George, S., Johnson, M. E., Meyerdirk, l., Kuhn, E., Steiner, J., Madaj, Z., Ma, J., Becker, K., Nilsson, P. R., Colca, J., Brundin, P. Abstract: Epidemiological studies suggest a link between type-2 diabetes and Parkinsons disease (PD) risk. Treatment of type-2 diabetes with insulin sensitizing drugs lowers the risk of PD. We previously showed that the insulin sensitizing drug, MSDC-0160, ameliorates pathogenesis in some animal models of PD. MSDC-0160 reversibly binds the mitochondrial pyruvate carrier (MPC) protein complex, which has an anti-inflammatory effect and restores metabolic deficits. Since PD is characterized by the deposition of alpha-synuclein (aSyn), we hypothesized that inhibiting the MPC might directly inhibit aSyn aggregation in vivo in mammals. To answer if modulation of MPC can reduce the development of aSyn assemblies, and reduce neurodegeneration, we treated two chronic and progressive mouse models; a viral vector-based aSyn overexpressing model and a pre-formed fibril (PFF) aSyn seeding model with MSDC-0160. These two models present with distinct types of aSyn pathology but lack inflammatory or autophagy deficits. Contrary to our hypothesis, we found that a modulation of MPC in these models did not reduce the accumulation aSyn aggregates or mitigate neurotoxicity. Instead, MSDC-0160 changed the post-translational modification and aggregation features of the aSyn. These results are consistent with the lack of a direct effect on MPC modulation on synuclein clearance in these models. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.18.253427v1?rss=1 Authors: Sahu, D., Biswal, S. C., Malik, M. Z., Sahu, S., Kaushik, S. R., Sharma, S., Saini, E., Arya, R., Rastogi, A., Sharma, S., Sen, S., Singh, R. K. B., Nanda, R., Panda, A. K. Abstract: Troxerutin (TXR), a phytochemical reported to possess anti-inflammatory and hepato-protective effects. In this study, we aimed to exploit anti-arthritic properties of TXR using an adjuvant induced arthritic (AIA) rat model. AIA induced rats showed highest arthritis score at disease onset and by oral administration of TXR (50, 100, 200 mg/kg body weight), reduced to basal level in a dose dependent manner. Isobaric tag for relative and absolute quantitative (iTRAQ) proteomics tool was employed to identify deregulated joint homogenate proteins in AIA and TXR treated rats to decipher probable mechanism of the TXR action in arthritis. iTRAQ analysis identified a set of 434 joint homogenate proteins with 65 deregulated proteins (log2 case/control [≥]1.5) in AIA. Expressions of a set of important proteins (AAT, T-kininogen, vimentin, desmin, nucleophosmin) that could classify AIA from healthy were validated using Western blot analysis. Western blot data corroborated proteomics findings. In silico protein-protein interaction study of joint homogenate proteome revealed that complement component 9, the major building blocks of the membrane attack complex (MAC) responsible for sterile inflammation, gets perturbed in AIA. Our dosimetry study suggests that a TXR dose of 200 mg/kg body weight for 15 days is sufficient to bring the arthritis score to basal levels in AIA rats. We have shown the importance of TXR as an anti-arthritis agent in AIA model and after additional investigation its arthritis ameliorating properties could be exploited for clinical usability. Copy rights belong to original authors. Visit the link for more info

Tom talks to Abigail Shrier, columnist and author of "Irreversible Damage: The Transgender Craze Seducing Our Daughters." Abigail talks about the many young girls who misread their emotions and make dangerous and sometimes permanent changes to themselves.You can get the book here: https://www.amazon.com/Irreversible-Damage-Transgender-Seducing-Daughters-ebook/dp/B07YL6XK55 Follow her in Twitter here: @AbigailShrier Follow Tom on Twitter: @Tomshattuck More Tom stuff at www.tomshattuck.com Tom's "Insta" as the zillenials say: www.instagram.com/calvincaspian/ The opening theme music is called Divine Intervention by Matthew Sweet The closing theme music to this podcast is C'est La Vie by Derek Clegg. Tom is an Editor at the Lowell Sun newspaper. Please consider a subscription: checkout.lowellsun.com/ Dave has been spending extra time in the yard to think about his actions. Federal troops are heading to Chicago - the greatest city on Earth. NYC may actually be the greatest but the people are nicer in Chicago. Excelsior!

To tweet? Or not to tweet? Where is truth?

Headkicks! Rear Naked Choke! The toughest people on Earth...besides moms.

“Just because something is hard in the beginning doesn't mean it's always going to be.”Robbie BalengerImagine running an ultramarathon. It’s a huge undertaking for anyone. And a bucket list dream for many.Now imagine running an ultramarathon every day. A minimum of 40 miles, 75 days in a row. Starting in Los Angeles. Finishing in New York. A 3,200 mile transcontinental run.This is the story of Robbie Balenger.Just 6 years ago, Robbie laced up his first pair of running shoes to alleviate the stress he was experiencing managing a restaurant. A small act, that first run set in motion a chain of events that led to a passion for running long distances, followed by a purpose-driven mission promote a message — the power of a plant-based diet to fuel athletic performance. Prevent and reverse certain lifestyle maladies. Ameliorate suffering. And redress climate change.What Robbie didn't expect? The many extraordinary ways running creates community. Unites people across the economic divide. And bridges the political differences that drive us apart.I was unfamiliar with Robbie until an e-mail hit my inbox courtesy of my friend and former podcast guest, Olympic cyclist Dotsie Bausch (RRP 355). Her non-profit Switch4Good was sponsoring Robbie's attempt to cross the United States by foot. Would I be interested in helping to support their efforts? I jumped at the opportunity.On March 16, I showed up at dawn in Huntington Beach to meet Robbie for the first time and help kick off his momentous attempt.Running the first several miles alongside Robbie and a small crew of supporters, I immediately took to his earnest yet humble disposition. His passion for promoting the benefits of a plant-based lifestyle. And his determination to reach New York a mere 75 days later.We struck up a friendship that day. I kept keen tabs on his progress over the following months. And made him a promise:Finish the run and you earn a seat at the podcast table.All heart, he indeed finished it. Today I honor that promise. And it’s a great story, well told.You can watch it all go down on YouTube. And as always, the conversation streams wild and free on Apple Podcasts and Spotify.I sincerely hope you enjoy the exchange as much as I relished having it.Peace + Plants,Listen, Watch & SubscribeApple Podcasts | YouTube | Spotify | Stitcher | Google PodcastsThanks to this week’s sponsorsCaldera Lab: Premium non-toxic skincare for men didn't exist – so we created it! Clinically- proven & wild-harvested in Jackson Wyoming. Go to: calderalab.com/richroll to get 20% off their first purchase of ‘The Good' or use discount code RICHROLL at checkout.ROKA Eyewear: Cutting-Edge Eyewear & Apparel Built For Top Performance. We Don’t Cut Corners. See acast.com/privacy for privacy and opt-out information.

Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations. --- Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

EPISODE 4. / Back from the brink, Jaclyn Hill finally breaks her silence but what is she actually saying? Kylie Jenner delves into suncare and the holy grail makeup artist Pat McGrath gets ready to once again do no wrong.Did someone say antioxidants? One of the original buzz words that started it all! We all know how good they are for your insides but why would you put them on your face?! Oh, Ameliorate, the underground cult favourite - never heard of it? Let us introduce you to this unique game-changing moisturiser that won’t break the bank!Follow us on Instagram @allbasescovered.pod for behind the scenes content and swatches, or DM us for future product trials or #beautybreakdown suggestions. For information regarding your data privacy, visit Acast.com/privacy See acast.com/privacy for privacy and opt-out information.

Ameliorate is a verb that means to make something better. The French word meilleur (me YARE) beans ‘better.’ This is where our word of the day comes from. Ameliorated is often, but not always, used in a medical context. When I was ill, I found that chicken soup ameliorated my cold. With every sip, I could feel my symptoms slowly fade away.

In this episode we talk about Joe's first visit with a counselor and some of the ideas behind going to a therapist. Channing discusses the ever depressing struggle to find fulfillment in life's pursuits. Joe talks a little about cold showers and ponders why some of us are never content. 

Marijuana use for medical purposes is becoming increasingly common in the U.S., and doctors prescribe it for ills ranging from headaches to insomnia. And yet, there is little scientific data supporting its medical use. In this podcast, Drs. Margaret Haney and Eden Evins discuss the relationship between cannabis use and two psychiatric disorders: post-traumatic stress disorder and psychotic illnesses, particularly schizophrenia. See acast.com/privacy for privacy and opt-out information.

Dr. Keller discusses how communication skills training ameliorates burnout and can promote satisfaction at work. Presented November, 10, 2015

4am CAB Presents… Joking Around – One man’s journey into stand up comedy, from page to stage and beyond. Episode 31 – Ameliorate So I finally get the chance to try out my new stuff this week, I say finally but … Continue reading →

In today's episode, it's time to catch up on the knitted projects. Plus, an essay by British writer and Druid, Nimue Brown.Shownotes: News & Noteworthy:-contest draw (yarn or spinning fibre) winner - Jennifer, Naamah13. For “On and Off the Needles”:“Off” Projects only today:Irish Coffee, by Thea ColmanYarn: Madelinetosh Chunky, 100% SW merino, aran weight, colourway “Rambler”.Telemark Pullover, by Erika FloryYarn: Gaia's Colours, Pales Twisty DK, colourway “Azur-Ava”.Rae scarf, by Jane Richmond Yarn: Purple Label MCN fingering by Tanis Fiber Arts, in the “Autumn Sun” colourway (September 2011 sock club yarn).Diagonal Lace socks, by Wendy Johnson Yarn: Skinny Bugga, 80/10/10 true fingering, by Sanguine Gryphon, in muted rainbow colourway “Frog-legged Leaf Beetle”. Sedum cardigan, by Jane RichmondYarn: Bernat Roving (single-ply bulky, 80% acrylic/20% wool) in “putty” colourway.A Test knit unnamed cardigan by Carol Feller, to be released next year. Made the one-year sizeYarn: Berocco Vintage Chunky in a pale bright green.Ameliorate fingerless mitts, by Hunter HammersenYarn: Gaia's Colours Fibre Arts, Silkie Sock in the colourway “Lolita”.Hacky Sack Hoodie, by Stef Pulford from the Son of Stitch n' Bitch bookYarn: Cascade Eco Wool, deep charcoal gray, 100% wool. Color Affection, by Vera ValimakiYarn: Fiberphile yarns, MCN luxe sock, 375yards/343metres, in “Stardust” and “Honey Amber”, and Earthly Hues Seedlings sock yarn (MCN), 375yards/343metres) in “Sunshine”.Song - Sora, “Heartwood”The Pagan Corner:Nimue Brown's essay - “Ancestors of Yarn”"I'm not sure when humans started spinning wool from fleece, but it goes back a long way into our history as a species, I assume to our first settling as farmers rather than being nomadic hunter gatherers. Yarn has played a significant part of life since then, as clothing and bedding, decoration, comfort, and art form. It's also traditionally a very female activity, in the western world, although I believe in South America knitting is one of those hard core macho things that men get together to do. Which goes to show that like most gender things it actually has more to do with culture than physicality.Our female ancestors then, for most of human history, were involved with yarn. A woman might be buried with her distaff even. Spinning, weaving, making and mending are traditional women's work. The methods we have, from the spindle and spinning wheels to knitting and crochet also connect us to the people who invented, developed and perfected them. Like so many of our ancestors, the yarn innovators are largely unknown, and there were probably a great many of them.Every woman who passes down this skill to a girl, is part of a huge web of weaving tradition. I learned knitting from my mother, crotchet from the mother of a boyfriend, spinning from several friends, although I'm not very good at it! I learned naalbinding (which might not be how you spell it!) to make traditional Viking socks, which take forever but are stunningly substantial. The wool work doesn't come alone though. Alongside it come the tales of other knitters and crafters, family myths and anecdotes. While the hands are busy, the mind has plenty of room to wander.I find wool work incredibly soothing. If I'm rattled, my mind in chaos and my body weary, then to sit down with wool is one of the best therapies. The rhythm of it is innately soothing. Watching small pieces of creativity form between my fingers is affirming, settling. The stories and inspiration of other wool workers are very much with me, and I feel part of something much bigger than I am. There's a power in weaving, knitting, spinning – the power to take the raw materials of nature and fashion them into something essential for life in a cold climate. Wool for our ancestors must have contributed to survival, a vital part of culture that made human life viable in tough locations.I heard a story once, that Arran sweaters have complex designs because each family had its own pattern. The women made them so that if a drowned sailor washed ashore, they could figure out who he was, who his people were. I can't imagine making a jumper for my man that would mark him as mine in case he died, that must take a certain kind of pragmatic courage.Modern life is full of things that claim to be convenient, but that take far more from us than they give. I know a lot of women who are returning to wool, or learning it anew, because it makes sense to them on an emotional level as well as a practical one. Being able to do the essential things of life matters and in turn makes your life feel more real. Ancestral pursuits like this bring a sense of stability, rootedness and belonging. We need that. In cultures full of uprooted people, in times where continuity and certainty are hard to come by, reaching back into the past makes a lot of sense. The ancestors are all there, behind us. A sense of belonging is a precious thing to have when everything else feels a bit fragile and uncertain. Between climate change and the world economies, and the insane priorities of politicians, life for any aware person is not comfortable, even in our relatively insulated western world.The wool tribe is there, for anyone willing to pick up the threads and find out how to make them. Your grandmothers will have done it, and your great grandmothers. The odds are you had some distant grandfathers who kept or sheared sheep, too. Go back far enough and most of us have that, in fact. The threads of wool can also be threads of continuity, safety lines to remind us of where we came from and how we connect to the other creatures, and to the earth. We can bind our own stories into the wool."Anyone interested in a deeper look at ancestry, from an overtly Druid perspective, is invited to pick up a copy of Nimue's new book, Druidry and the Ancestors.  She blogs most days at Druidlife

Transcript -- In this video two fitness trainers share their experiences of how exercise adherence can be improved.

In this video two fitness trainers share their experiences of how exercise adherence can be improved.

Transcript -- In this video two fitness trainers share their experiences of how exercise adherence can be improved.

In this video two fitness trainers share their experiences of how exercise adherence can be improved.