Podcasts about inhibiting

The Surpassing Glory of God's Promises in Christ 2 Corinthians 3:7-18 Our sermon text is from 2 Corinthians 3 verses 7-18. We learned in the beginning of chapter 3 that the apostle Paul was a minister of a New Covenant. That new covenant is received through the Spirit and resulted in life. That is contrasted with the letter of the law, which, as Paul put it, kills. The rest of chapter 3 unpacks the old and new covenants. As I read, listen for the similarities and differences between the two. Reading of 2 Corinthians 3:7-18 Prayer I don't know if you have been following it, but later this week, 7 planets will be visible in the night sky at the same time. That is a rare event. In fact, it's been quite the season of interesting astrological occurrences. Maybe you experienced the partial solar eclipse last year. Or 5 years ago, you saw the great conjunction. That was when Jupiter and Saturn overlapped in the sky. Apparently, that only happens once every 400 years. And coming up in just 3 weeks, there will be a total lunar eclipse. You are probably wondering, how does this relate to 2 Corinthians 3? Well, 2 Corinthians 3 is considered by some to be the most difficult chapter to understand in all of Paul's letters. That's debatable, of course, but it certainly contains some lofty concepts. At this chapter's core is the theological intersection between the Old and New Testaments. That's significant. And obviously important. And that brings us to the moon and sun and planets. You see, the central point is that the glory of the old covenant was a fading reflection of the glory of the new to come. The new covenant has come and it has eclipsed the glory of the old. It's like the way the moon and planets reflect the light of the sun at night. But when the sun rises, its light is so bright that it completely outshines the moon and planets. The old covenant reflected the new before the new came, but the new has come, and the old has now passed away. By the way, this is one of two main passages of Scripture that compare the old covenant with the new. Hebrews chapter 8-10 is the other. We read part of chapter 10 earlier. The difference between Hebrews 8-10 and 2 Corinthians 3 is that Hebrews works through how God accomplished his promises in the new covenant. He's done that through Jesus perfect sacrifice for sin. In 2 Corinthians 3, we learn about the permanent nature of the new covenant and that we receive its benefits through the Spirit. So both teach about the old and new covenant but with different emphases. Earlier this week I spent some time analyzing how 2 Corinthians 3 compares the old and the new. I put a little chart together as I went. You can see that on page 4 of the bulletin. Really, it was for my benefit as I tried to get my mind around the contrast. But I included it in case it may be helpful to you. You can see that Paul's primary purpose here is a comparison of the two. ·       He gives us the nature of the covenants. The old carved on stone and the new written by the Spirit on our hearts. ·       He speaks of the fading glory of the one and the eternal glory of the other. ·       The old primarily focused on Israel, but the new expands that to God's people from all nations. ·       Even more, those who live by the old live with a veil over their hearts. But for those who have been freed by Christ, that veil is lifted and they are being transformed. ·       But the most weighty of all the comparisons is the eternal outcome. Those who put their trust in the old and reject the new are condemned. But those whose hearts have been transformed by the Spirit and who trust in Christ receive righteousness and life through the Spirit. It's really amazing how much is here in just a couple of paragraphs. Alright. We are going to focus in, first, on understanding the comparison, verses 7-11. And then we'll look at implications of that, today, in verses 12-18. You can see a few summary bullets there. Now, you may be wondering, why does it take such work to unlock the differences between the two? That is a great question. I wondered the same. Because it does seem that Paul jumps around and repeats himself. Why didn't he just spell it out in a clear linear way? The answer is, to his readers, he did. Paul spelled it out in a way they would understand. He used a Greco-Roman rhetorical argument called “a fortiori.” Lesser to greater. That will be on the test after the service. Just kidding. I had no idea that such a thing existed before this week. The argument goes that if something lesser is true, how much more sure and true is the thing that is greater. Its purpose is to elevate the greater reality. To do that there's a comparison and an elevation. And another comparison and another elevation. And then a further elaboration on a comparison and a further elevation. We can see that in these verses. One thing that clearly comes out is the amazing, surpassing, never ending glory of the new covenant. Look at verse 10 for example. “For if what was being brought to an end came with glory, much more will what is permanent have glory.” You see, these verses are not just a technical explanation. Rather, Paul was elevating the hearts of the Corinthians. He wanted them not only to know that the new is greater and eclipses the old, but he wanted their hearts to see and rejoice in what God has done. How he has fulfilled all the promises of the old in the new. Going back to the moon and sun… you know, when it comes to light and energy, there's no comparison. The moon can only reflect the light of the sun. Yes, in the middle of the night, when a full moon is out it really lights up the surroundings. You can even see shadows. You can see where you are going. If you wanted to, you could even turn off your car's headlights. Don't do that, though… but you would be able to see. But where does that light from the moon and planets come from? It comes from the sun. The light of the sun reflects off of them. The old covenant reflected the glory of the new which, in the Old Testament times, had yet to come. But also, let me ask, what is the lunar surface of the old covenant? Meaning what is the light from the new reflecting off of? Well, it reflects off of (1) the moral law, you know, the letters carved on stone – the 10 commandments, and it reflects off of (2) other laws that God gave through Moses like the ceremonial laws including sacrifices… and also (3) festivals and (4) the temple itself. All of it, in different ways, reflected the glory of what was to come in the new covenant. And they all tie together the Old Testament with the New Testament in profound ways. Ways that help us better understand the new. In the past, I've shared a little of my journey to seeing the Bible as one unified book. I remember when I was, I think, 22 years old. I could not wrap my mind around the purpose of God's law nor even the purpose of the Old Testament. It was a burning question in my mind. I couldn't let those questions go. Well, my Bible had cross references in the margins. And so, I set out to read through the New Testament and cross reference every single Old Testament cross reference. I worked on it a little bit every day. It took me about 3-4 months. It blew my mind. By the way, I still have that Bible in my office with a bunch of underlines and notes. Light bulbs kept going off as I saw more and more connections between God promises and laws in the Old and their fulfillment in Christ in the new. Before then, I used to think that the Old Testament had so many strange practices and peculiar events that had no relevance. But then their beauty came alive to me. I realized how in different ways they revealed God in his glory, they revealed his plan for redemption, and they revealed the need for atonement and the Messiah. All of those old covenant things were driving at what was to come. You see, for God's people in the Old Testament, the whole purpose of the different laws and ceremonies was to direct their attention to the promise of what was to come. Let me say something that is really really important. It was never about offering the sacrifices and obeying the law as a means for salvation. Never. Rather it was so that they could trust in God for what he would do. Their salvation was received by faith in Christ who was to come just as ours is received by faith in Christ who has come. This is illustrated for us in what happened at Mount Sinai. These verses in 2 Corinthians 3, refer to Moses veiling his face. You see, when the Israelites were freed from their slavery in Egypt, God brought them across the Red Sea and he brought them to the base of Mount Sinai. And God then called Moses to ascend the mountain to receive the law. And so Moses went. But in the meantime, the people began worshipping a golden calf instead of the one true God. And God's anger burned against the people. But… Moses pleaded with the Lord for mercy. And God relented. Moses was a mediator between God and his people. After that, God commanded Moses to go up the mountain again. Actually, he needed a new copy of the law because he had thrown down the first. But also, this time, God revealed his glory to Moses. Moses was only given a glimpse of God in his glory, but it caused Moses face to shine with the glory of God. When Moses descended, the people were afraid because of the reflected glory. And so Moses would veil his face to protect the people. Look at 2 Corinthians 3 verse 7. It says, “the Israelites could not gaze at Moses' face because of its glory.” Even the reflected glory was unbearable because of their sin. Again, Moses acted as a mediator of God's mercy by veiling his face. We learn a couple things from that. We learn there is glory in the law. As I mentioned last week, God's moral law is good and right and perfect. It reveals God's nature and his goodness. But it is only a reflected glory. We also learn that God's law requires a mediator, just as Moses mediated for the people. So, the law both directs us to God and it directs us to our need for Christ because of our failure to meet its standard. That explains verse 9. Look at it. “For if there was glory in the ministry of condemnation, the ministry of righteousness must far exceed it in glory.” The law is glorious but without a mediator, it brings condemnation. But the mediator of the new covenant has come. Christ has come. And he's accomplished and has fulfilled all that the law required. We are no longer condemned by the law. Through Jesus' righteousness, we are given life. That phrase in verse 9, “ministry of righteousness” is referring to the righteousness we have in Christ. You see, the sunrise has come. The sun is up. Yes, in the daytime we can faintly see the moon and we can occasionally see a planet. But the moon and plants no longer light anything up. Because the day has come. There's no more need for the reflected glory of the old because of the surpassing and permanent glory of the new covenant. Alright, let's now turn our attention to the implications for us -  verses 12-18. There are two implications - one negative and one positive. The first is when you only see the old and you reject the new. Look at verse 14. Paul, talking about unbelieving Israel, says, “For to this day, when they read the old covenant, that same veil remains unlifted, because only through Christ is it taken away. Yes, to this day whenever Moses is read a veil lies over their hearts.” Now, I don't think that there are any Jewish people here today who reject Christ. But that is who Paul is speaking about. They read the Old Testament. Some may think that by obeying the laws and celebrating the festivals that they are therefore justified in God's sight. They may even believe in a coming Messiah. But their hearts and minds are hardened and veiled. It would be like believing that the moon is shining with its own source of energy and light. And maybe even believing that sun does not exist. It would be like covering your eyes during the day so that you don't see the sun. Or sleeping when the sun is up and only being awake at night. They do not believe the new. They are trusting in the old for salvation. And because of that unbelief, to use Paul's earlier words, they will receive “the ministry of condemnation.” Let me expand this a little. I think there are some parallels here to the Roman Catholic church. In our church history Sunday school class this morning, we talked a little bit about the counter reformation. That was the church in Rome's response to the Protestant Reformation. And while yes, much of the immorality in the church was addressed, yet, the church doubled-down on many of its beliefs. Now, I know there are some faithful believers in the Catholic church, but over the centuries, the church has added unbiblical layers that veil Christ. Like the veneration of Mary, or like praying to the saints, or believing in an intermediate state to work off your sins, or going to a priest for intercession. Those are all merit-based or works-based righteousness things. They are in essence veiling the glory of God in Christ. It's kind of like a partial solar eclipse. The fulness of the glory of God in Christ cannot be fully seen. And because of it, many in the Catholic church, trust in these things and not the ministry of God in Christ. There are other parallel as well… like any rejection of the new covenant in Christ. That would include the “I'm a good person” theology. The belief that God will evaluate our good works and because of them consider us good in his sight. That is just a version of the old covenant which cannot save. It denies the sin and idolatry of our hearts and rejects the new covenant. Let me ask, how should we respond? How should we, who believe in the new covenant, respond to those groups? Well, we should seek to be ministers of the New Covenant, like Paul. What does that mean? That means praying for the work of the Holy Spirit to remove the veil over their hearts. It means revealing the failure of the old or the law to redeem. It means doing what Paul does here. Showing the glory of God in the ministry of the new covenant! Its exalting the person and work of Christ through his Spirit! It's showing what unveiled worship is as we behold God. Remember, it's not peddling God's Word, but rather it's exalting God for the exceeding glory of the new. Ok, there's another implication here. A positive one. And it relates to my favorite verse in this chapter. Look at verse 18. “And we all, with unveiled face, beholding the glory of the Lord, are being transformed into the same image from one degree of glory to another. For this comes from the Lord who is the Spirit.” I love that verse. Paul is speaking about those transformed by the ministry of the new covenant. Those whose hearts are not hardened nor veiled but who, through Christ, can behold the glory of God without condemnation! Those who have the ministry of his righteousness because our hearts have been transformed by his Spirit. And when we behold the wonder and glory of God in what he has accomplished, he does something in us. Or rather he is doing something in us. He is transforming us. He is conforming us to the image of Christ. More and more we will reflect his glory… in our countenance, in our thoughts, in our words, in our actions – in our hearts. Now, we can certainly inhibit that transformation. Our sin can block the light of the sun. As you know, this last week has been a little cold. But if you were outside during the day when it was sunny, you really got warmed by the sun. Inhibiting that transformation is like blocking the sun in some way. We do that when the comforts of this world become idolatrous. Or when our lust or anger or some other sin goes unchecked and unrepented of. Or when we forget to pray or engage in God's Word. All those things cause us to become cold.  They all inhibit the light of the sun reaching us… by our own doing. They all inhibits the transformation of God within us. But, as verse 18, says, when we behold God with unveiled face. When we come to him laying our sin before him, letting his Word wash over us. When glorying in the ministry of the new covenant becomes our life and righteousness, then God will be transforming us! He'll be transforming us from one degree of glory to another. These verses are not saying that we will become perfectly glorified. That will only happen when we pass from this life to the next. But more and more we will reflect the glory of God in Christ. And we will radiate that glory like the face of Moses. By the way, did you notice that the Lord is equated with the Spirit… multiple times, here. That word Lord, used here, is in reference to Jesus. What Paul is doing here is he is affirming God's oneness in the Trinity. It's not overlapping the roles of the Son and the Holy Spirit. The Holy Spirit applies the work of Christ in us. In fact, multiple times in the New Testament he is called the Spirit of Jesus. Christ works in us through his Spirit, to transform us from one degree of glory to another. It is his work. And that ties back to the new covenant. The ministry of the new covenant is the ministry of the Holy Spirit in us, not the ministry of the law. So, God has fulfilled all the promises of the old in the new. The glory of the old has faded away, and the surpassing glory of the new has come in Christ. The moon has set and the sun has risen. So may we all with unveiled hearts, behold the glory of God through the Spirit of the Lord Jesus. Amen.

Dave Lee discusses the contentious topic of estrogen in men's TRT. He highlights the polarized views surrounding estrogen testing and aromatase inhibition, emphasizing the confusion it creates for patients and leads many men to chase an unrealistic “Goldilocks zone” of estrogen inhibition. Key Takeaways: Blocking estrogen is unnecessary and harmful. Many of the benefits of testosterone come from its natural conversion into estrogen and DHT. Inhibiting this process can lead to negative side effects. The real problem isn't estrogen—it's inflammation and poor metabolic health. If men experience “estrogenic side effects,” it's usually due to improper dosing or metabolic dysfunction, not an inherent issue with estrogen itself. Testosterone dosing should prioritize stability. Weekly or biweekly injections create hormone fluctuations that cause side effects. Dave advocates for more frequent injections (at least three times per week) or using trans-scrotal testosterone cream, which provides a more stable and effective delivery method. Excess body fat contributes to unwanted estrogenic effects. Men with higher body fat percentages will naturally convert more testosterone into estrogen. The solution isn't blocking estrogen but losing fat through proper nutrition and exercise while optimizing TRT dosing. Victory Men's Health provides comprehensive hormone care. Clinics like Victory look beyond testosterone alone, addressing thyroid health, DHEA, pregnenolone, and insulin sensitivity for a more holistic approach to hormone optimization. Dave emphasizes that TRT should be customized based on an individual's health, lifestyle, and response to treatment. If you're struggling with side effects, the answer isn't to suppress estrogen but to refine your protocol and address underlying health factors. Dave Lee Instagram Click Here Victory Men's Health Click HereVictory Men's Health YouTubeFor questions email podcast@amystuttle.com Disclaimer: The Women Want Strong Men Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

How will inhibiting supportive housing impact the DTES? Guest: Guy Felicella, Harm Reduction and Recovery Advocate Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapamycin appears to be a universal anti-aging drug, extending the lifespan of all animals tested to date; it's the only known drug to do so.

David Happel is President and CEO of Sagimet Biosciences, a company developing drugs to treat metabolic diseases by targeting the underlying cause of fat accumulation in the liver. The drug denifanstat limits the activity of fatty acid synthase (FASN), an enzyme that regulates fat accumulation. This approach is a fat inhibitor, not a fat burner, the focus of other MASH drugs.  David explains, "Sagimet was founded back in 2007 as a private company with a group of medicinal chemists that had a particular target in mind, and this particular target was called fatty acid synthase, or FASN. FASN is a rather ubiquitous enzyme throughout the body that functions as a regulating enzyme in many organs. When FASN becomes overactive or overexpressed, it sort of throws things out of balance and, in particular, certain cardiometabolic diseases, such as MASH and in the liver. So, this group of chemists, in order to resolve this overactivity, developed a portfolio of FASN inhibitors, led by our lead program denifanstat, that seek to target the underlying cause of MASH and, therefore, really work to limit the activity of FASN, try to normalize it essentially is what we do." "For us and this particular molecule, it offers a differentiated approach to treating the disease for us and this particular molecule. Our molecule, denifanstat, is the only FASN inhibitor. It's the only fat inhibitor in development for MASH, making it rather unique. All the rest of the molecules or fat burners, fat oxidizers, and fat mobilizers include GLPs, FGF, and THR-beta. They all function by trying to burn fat peripherally and in the liver to a degree. They rely on that fat-burning mechanism to translate into reductions, inflammation, and fibrosis, which is important to treating MASH, but they've had varying degrees of success. Our molecule targets each pathway independently: fat, inflammation, and fibrosis, and has had a rather pronounced treatment effect as a result."  #SagimetBiosciences #MASH #FattyLiverDisease #FASN #FASNInhibitor #Fibrosis #Obesity #NASH #GLP1Agonists sagimet.com Download the transcript here

David Happel is President and CEO of Sagimet Biosciences, a company developing drugs to treat metabolic diseases by targeting the underlying cause of fat accumulation in the liver. The drug denifanstat limits the activity of fatty acid synthase (FASN), an enzyme that regulates fat accumulation. This approach is a fat inhibitor, not a fat burner, the focus of other MASH drugs.  David explains, "Sagimet was founded back in 2007 as a private company with a group of medicinal chemists that had a particular target in mind, and this particular target was called fatty acid synthase, or FASN. FASN is a rather ubiquitous enzyme throughout the body that functions as a regulating enzyme in many organs. When FASN becomes overactive or overexpressed, it sort of throws things out of balance and, in particular, certain cardiometabolic diseases, such as MASH and in the liver. So, this group of chemists, in order to resolve this overactivity, developed a portfolio of FASN inhibitors, led by our lead program denifanstat, that seek to target the underlying cause of MASH and, therefore, really work to limit the activity of FASN, try to normalize it essentially is what we do." "For us and this particular molecule, it offers a differentiated approach to treating the disease for us and this particular molecule. Our molecule, denifanstat, is the only FASN inhibitor. It's the only fat inhibitor in development for MASH, making it rather unique. All the rest of the molecules or fat burners, fat oxidizers, and fat mobilizers include GLPs, FGF, and THR-beta. They all function by trying to burn fat peripherally and in the liver to a degree. They rely on that fat-burning mechanism to translate into reductions, inflammation, and fibrosis, which is important to treating MASH, but they've had varying degrees of success. Our molecule targets each pathway independently: fat, inflammation, and fibrosis, and has had a rather pronounced treatment effect as a result."  #SagimetBiosciences #MASH #FattyLiverDisease #FASN #FASNInhibitor #Fibrosis #Obesity #NASH #GLP1Agonists sagimet.com Listen to the podcast here

Free book is here at https://www.memorizingpharm.com/books Summary Chapter 3.19 Antitubercular Chapter 3.19 discusses antitubercular medications used to treat tuberculosis (TB), which primarily affects the lungs. These drugs work by inhibiting mycobacterial growth or disrupting RNA synthesis, requiring long-term treatment (6 months to 2 years). Key considerations include monitoring liver function, avoiding alcohol, and ensuring patient adherence to therapy. Common medications include isoniazid and rifampin. Multiple Choice Questions How do antitubercular medications primarily work? a) Inhibiting protein synthesis b) Inhibiting mycobacterial growth c) Enhancing DNA replication d) Blocking cell wall formation How long does antitubercular therapy usually last? a) 1 month b) 3 months c) 6 months to 2 years d) 1 week Which organ's function should be closely monitored during antitubercular therapy? a) Heart b) Liver c) Kidney d) Lungs Which substance should patients avoid during antitubercular treatment? a) Caffeine b) Alcohol c) Dairy d) Citrus fruits What is a commonly used antitubercular medication? a) Penicillin b) Isoniazid c) Acyclovir d) Metronidazole Answer Key b) Inhibiting mycobacterial growth c) 6 months to 2 years b) Liver b) Alcohol b) Isoniazid

Send us a textIn this Ones Ready Podcast episode, Aaron and Peaches sit down with Dr. Tim Vermillion to explore essential topics on mental health, stress management, and support for military veterans. Dr. Vermillion shares his personal journey from the military to becoming a therapist, offering valuable insights into the impact of stress on the body and mind. They delve into the importance of breath work, physical activity, and the early signs of unhealthy coping mechanisms. Dr. Vermillion explains therapeutic approaches like cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR) for treating PTSD.The conversation also touches on groundbreaking treatments, including psychedelic therapies, hyperbaric therapy, and transmagnetic stimulation, with a focus on the VA's ongoing research. Dr. Vermillion emphasizes the critical role of active listening, non-confrontational support, and the military's efforts to destigmatize mental health struggles. He encourages veterans to seek help and be open about their challenges, offering hope through new and evolving therapies.Chapters00:00 Introduction and Background09:45 Understanding Stress and Its Management18:29 The Role of Breath Work and Physical Activity22:18 Recognizing Early Warning Signs of Unhealthy Coping26:23 Treating PTSD with CBT and EMDR32:23 Expanding Stress Tolerance34:18 Supporting Others in Managing Stress and Trauma34:31 Supporting Veterans' Mental Health36:05 Active Listening and Non-Confrontational Approaches37:02 Avoiding Directive Language38:09 Substances and Inhibiting the Healing Process40:29 Self-Medication and Negative Effects41:35 Comparing Substances: Alcohol, Tobacco, and Marijuana48:07 Destigmatizing Mental Health in the Military51:47 Following Mentors and Gaining Tacit KnowledgeSupport the showJoin this channel to get access to perks:https://www.youtube.com/channel/UC9aFBBZoBcQk8UUN_pO7nDA/joinBuzzsprout Subscription page: https://www.buzzsprout.com/680894/subscribeCollabs:Ones Ready - OnesReady.com 18A Fitness - Promo Code: 1ReadyATACLete - Follow the URL (no promo code): ATACLeteCardoMax - Promo Code: ONESREADYHoist - Promo Code: ONESREADYThe content provided is for informational purposes only and does not constitute legal advice. The host, guests, and affiliated entities do not guarantee the accuracy or completeness of the information provided. The use of this podcast does not create an attorney-client relationship, and the podcast is not liable for any damages resulting from its use. Any mention of products or individuals does not constitute an endorsement. All content is protected by intellectual property laws....

Free book is here at https://www.memorizingpharm.com/books Summary Tetracyclines 3.13  Tetracyclines are broad-spectrum antibiotics that inhibit bacterial protein synthesis. They're effective against gram-positive and gram-negative bacteria but have limitations due to side effects like photosensitivity, teeth discoloration, and risks in pregnancy/children under 8. Patients should avoid direct sunlight, dairy, and use alternative birth control. Multiple Choice Questions Tetracyclines work by: a) Inhibiting DNA synthesis b) Inhibiting protein synthesis c) Blocking cell wall synthesis d) Disrupting RNA transcription A side effect of tetracyclines is: a) Weight gain b) Teeth discoloration c) Hair loss d) Increased energy Tetracyclines are contraindicated for: a) Elderly patients b) Children under 8 c) Diabetics d) Patients with asthma Tetracyclines should not be taken with: a) Water b) Dairy products c) Meat d) Vegetables Patients on tetracyclines should: a) Avoid sunlight b) Increase sugar intake c) Exercise more d) Consume more salt Answer Key b) Inhibiting protein synthesis b) Teeth discoloration b) Children under 8 b) Dairy products a) Avoid sunlight

This episode is a replay of an interview I did circa 2017 with patent attorney Stephan Kinsella.Kinsella is the author of "Against Intellectual Property," and in our time together, he argues that IP laws, particularly patents and copyrights, are incompatible with traditional property rights and hinder innovation and progress. The conversation explores the origins of these laws, their impact on musicians and other creatives, and practical advice for navigating the current system while protecting artistic integrity. The discussion also delves into Austrian economics and how it provides a framework for understanding the issues with IP laws. Kinsella foresees a future where the increasing ease of circumventing these laws will pressure the industry to adapt to more free-market principles.Episode highlights:00:24 Stefan Kinsella on Intellectual Property02:43 Understanding Property Rights06:45 Austrian Economics and Intellectual Property20:08 The History and Problems of Copyright26:59 Practical Advice for Musicians42:13 Future of Intellectual Property44:23 Conclusion and Final ThoughtsResources mentioned:Against Intellectual Property by Stephan KinsellaStephan's websiteAbout the guest:Stephan Kinsella is an attorney and libertarian writer in Houston. He was previously General Counsel for Applied Optoelectronics, Inc., a partner with Duane Morris, and adjunct professor at South Texas College of Law Houston. A registered patent attorney, he received an LL.M. (international business law) from King's College London, a JD from the Paul M. Hebert Law Center at Louisiana State University (LSU), and BSEE and MSEE degrees from LSU.He has spoken, lectured and published widely on both legal topics, including intellectual property law and international law, and also on various areas of libertarian legal theory. You've been listening to Ba Vojdaan!, with James D. Newcomb. For more information about James, and to subscribe to the podcast, visit https://jamesdnewcomb.com. There you'll find a trove of materials available for immediate download. And be sure to follow James' travels and adventures on social media. All the info can be found at https://jamesdnewcomb.com. Thank you for listening!

Free book is here at https://www.memorizingpharm.com/books Summary Chapter 3.12 Aminoglycosides Chapter 3.12 covers aminoglycosides, a potent broad-spectrum antibiotic class that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Commonly used for severe infections like streptococcal endocarditis, they are administered intravenously or intramuscularly. Major concerns include nephrotoxicity, ototoxicity, and neurotoxicity, requiring close monitoring of renal function, hearing, and nerve damage. Multiple Choice Questions How do aminoglycosides work? a) Disrupting cell walls b) Inhibiting protein synthesis c) Blocking RNA transcription d) Preventing DNA replication Which condition can be treated with aminoglycosides? a) Hypertension b) Streptococcal endocarditis c) Diabetes d) Migraine Which side effect should be closely monitored? a) Hypertension b) Ototoxicity c) Hair loss d) Weight gain How are aminoglycosides usually administered? a) Orally b) Topically c) Intravenously or intramuscularly d) Subcutaneously Patients should be advised to: a) Avoid sunlight b) Monitor for tinnitus c) Take with antacids d) Increase salt intake Answer Key b) Inhibiting protein synthesis b) Streptococcal endocarditis b) Ototoxicity c) Intravenously or intramuscularly b) Monitor for tinnitus

Free book is here at https://www.memorizingpharm.com/books Summary 3.10 Fluoroquinolones Chapter 3.10 discusses fluoroquinolones, a synthetic class of broad-spectrum antibacterial medications that inhibit bacterial DNA replication. Used to treat pneumonia, skin, and urinary tract infections, they are effective against gram-positive and gram-negative bacteria. Caution is needed due to the risk of serious side effects such as tendon rupture, neuropathy, and photosensitivity. Patients should avoid antacids and direct sunlight while taking this medication. Multiple Choice Questions Fluoroquinolones work by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking DNA replication d) Inhibiting RNA synthesis Which of the following is a serious side effect of fluoroquinolones? a) Weight gain b) Tendon rupture c) Increased appetite d) Hair loss Fluoroquinolones should be taken: a) With milk b) With antacids c) Two hours before or after meals d) With calcium supplements Fluoroquinolones are contraindicated in children except for: a) Ear infections b) Common cold c) Complicated UTIs d) Allergies Patients on fluoroquinolones should avoid: a) Sun exposure b) Drinking water c) Vegetables d) Carbohydrates Answer Key c) Blocking DNA replication b) Tendon rupture c) Two hours before or after meals c) Complicated UTIs a) Sun exposure  

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary and Quiz 3.9 Sulfonamides  Chapter 3.9 discusses sulfonamides, a class of broad-spectrum antibiotics. They inhibit bacterial growth by interfering with metabolic processes and treat conditions like UTIs and bronchitis. Side effects include hypersensitivity, crystalluria, and increased photosensitivity. Patients should be advised to stay hydrated, avoid direct sunlight, and complete their prescribed doses. Multiple Choice Questions Sulfonamides work by: a) Inhibiting protein synthesis b) Blocking folic acid synthesis c) Preventing DNA replication d) Disrupting cell wall synthesis Which condition are sulfonamides commonly used to treat? a) High blood pressure b) Urinary tract infections c) Diabetes d) Migraine headaches Patients taking sulfonamides should: a) Avoid dairy products b) Drink plenty of water c) Avoid exercise d) Increase salt intake A common side effect of sulfonamides is: a) Insomnia b) Photosensitivity c) Hair loss d) Weight gain What should patients report to their healthcare provider while on sulfonamides? a) Increased appetite b) Sore throat and rash c) Increased thirst d) Mild headaches Answer Key b) Blocking folic acid synthesis b) Urinary tract infections b) Drink plenty of water b) Photosensitivity b) Sore throat and rash ```

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary - 3.8 Monobactams Overview and Quiz  Chapter 3.8 of the Nursing Pharmacology guide covers monobactams, a narrow-spectrum antibiotic class primarily effective against gram-negative bacteria like Pseudomonas aeruginosa. Monobactams disrupt bacterial cell wall synthesis and are administered intravenously, intramuscularly, or via inhalation. Nurses should monitor for GI symptoms, skin sensitivities, and coagulation abnormalities. Patient education emphasizes watching for signs of superinfection or allergic reactions. Multiple Choice Questions Monobactams work primarily by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking DNA replication d) Preventing RNA transcription Monobactams are most effective against: a) Gram-positive bacteria b) Viruses c) Gram-negative bacteria d) Fungi How are monobactams commonly administered? a) Orally b) Topically c) Intravenously, intramuscularly, or via inhalation d) Subcutaneously What should patients monitor for when taking monobactams? a) Increased appetite b) Hair growth c) Signs of superinfection d) Weight gain Patients with allergies to which medication classes should be cautious with monobactams? a) Tetracyclines b) Penicillins, cephalosporins, or carbapenems c) Macrolides d) Antivirals Answer Key b) Disrupting cell wall synthesis c) Gram-negative bacteria c) Intravenously, intramuscularly, or via inhalation c) Signs of superinfection b) Penicillins, cephalosporins, or carbapenems  

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary Chapter 3.7 Carbapenems Chapter 3.7 of the Nursing Pharmacology guide discusses carbapenems, a broad-spectrum class of antibiotics used for serious, multidrug-resistant infections. These drugs disrupt bacterial cell wall synthesis and are effective against both gram-positive and gram-negative bacteria. They are administered intravenously and monitored for allergic reactions, particularly in those with penicillin or cephalosporin allergies. Patient education includes watching for signs of superinfection and potential side effects, even weeks after treatment. Multiple Choice Questions Carbapenems primarily work by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking RNA replication d) Preventing DNA transcription Carbapenems are most commonly used for: a) Mild respiratory infections b) Life-threatening, multidrug-resistant infections c) Treating viral infections d) Managing chronic pain What is a critical consideration before administering carbapenems? a) Monitoring liver enzymes b) Checking for penicillin or cephalosporin allergies c) Testing for heart rate d) Evaluating blood pressure How are carbapenems typically administered? a) Orally b) Topically c) Intravenously d) Subcutaneously Patients should contact their healthcare provider if they experience: a) Increased appetite b) Fever and bloody diarrhea c) Mild headaches d) Weight gain Answer Key b) Disrupting cell wall synthesis b) Life-threatening, multidrug-resistant infections b) Checking for penicillin or cephalosporin allergies c) Intravenously b) Fever and bloody diarrhea ```

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary 3.6 Cephalosporins Nursing Pharmacology  Chapter 3.6 of the Nursing Pharmacology guide focuses on cephalosporins, a class of antibiotics similar to penicillins. The chapter covers their mechanism (cell wall disruption), indications (skin, bone, respiratory infections), different generations with expanding spectra, and administration considerations. It also highlights monitoring for allergies, renal impairment, and possible disulfiram-like reactions with alcohol. Patient education emphasizes avoiding alcohol and reporting signs of superinfection. Multiple Choice Questions Cephalosporins work primarily by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Altering DNA replication d) Blocking RNA transcription Which generation of cephalosporins is effective against MRSA? a) 1st generation b) 2nd generation c) 4th generation d) 5th generation What side effect may occur when consuming alcohol with cephalosporins? a) Increased appetite b) Hair loss c) Disulfiram-like reaction d) Drowsiness Patients with allergies to penicillin might also react to: a) Cephalosporins b) Tetracyclines c) Aminoglycosides d) Fluoroquinolones What should be monitored when administering cephalosporins to a patient with renal impairment? a) Blood pressure b) Liver enzymes c) Blood urea nitrogen (BUN) and creatinine d) Heart rate Answer Key b) Disrupting cell wall synthesis d) 5th generation c) Disulfiram-like reaction a) Cephalosporins c) Blood urea nitrogen (BUN) and creatinine ```

Have you ever noticed that the smarter you are, the more you question yourself and the more you struggle to make the original contributions you are uniquely qualified to make? Well, I certainly have and that lead me to connect with another coach who is just as obsessed with helping high achievers overcome their resistance and avoidance, Jane Elliot, PhD. In this compelling conversation, Jane and I explore her framework for understanding and overcoming the four shades of avoidance - the spincyclers, overdeliverers, upper limiters, and white knucklers—unpacking how these behaviors manifest and impact driven women. We shed light on why perfectionism isn't just a standalone issue but a symptom of deeper resistance, and how being identified as gifted can be a burden, leading to genuinely painful struggles to reach inner and outer expectations. Jane and I share our insights on the spiritual aspects of using one's gifts in service to others, the identity struggles of highly intelligent individuals, and the importance of radical self-acceptance and continuous personal evolution. We discuss her innovative framework, and her quiz, inviting you to determine which type of “self-eating brain” is holding you back. You'll hear the inspiring success story of Regina, a lawyer-turned-novelist, and how Jane's transformative coaching program unblocked her brilliance.

Have you ever noticed that the smarter you are, the more you question yourself and the more you struggle to make the original contributions you are uniquely qualified to make? Well, I certainly have and that lead me to connect with another coach who is just as obsessed with helping high achievers overcome their resistance and avoidance, Jane Elliot, PhD. In this compelling conversation, Jane and I explore her framework for understanding and overcoming the four shades of avoidance - the spincyclers, overdeliverers, upper limiters, and white knucklers—unpacking how these behaviors manifest and impact driven women. We shed light on why perfectionism isn't just a standalone issue but a symptom of deeper resistance, and how being identified as gifted can be a burden, leading to genuinely painful struggles to reach inner and outer expectations. Jane and I share our insights on the spiritual aspects of using one's gifts in service to others, the identity struggles of highly intelligent individuals, and the importance of radical self-acceptance and continuous personal evolution. We discuss her innovative framework, and her quiz, inviting you to determine which type of “self-eating brain” is holding you back. You'll hear the inspiring success story of Regina, a lawyer-turned-novelist, and how Jane's transformative coaching program unblocked her brilliance.

Have you been feeling lately as though it's getting harder to get traffic to your website?    If you've noticed this trend, you're not alone. It's happening to everyone.    And as tempting as it might be to lay the blame for this on a tough economy or an upcoming election, that's actually not what's going on here.   In fact, what's really going on has the potential to have a lasting and very negative impact on your website traffic and sales unless you educate yourself and implement the right strategies to combat it.   And there are two very specific forces at play here that have nothing to do with your customers' spending power and everything to do with changes in technology.   For those of us who want to continue to thrive in an online business like eCommerce, we must do our best to understand how these changing technologies are affecting our ability to attract and convert customers.    Which I realise that sometimes feels like an impossible task given how fast things keep changing all the time, but that's why I'm sharing what we know, learn and discover here on this podcast! Episode's Show Notes: https://www.catherinelangman.com/episode-234/     Links mentioned in this episode: If you'd like help to achieve your goals in 2024 I invite you to have a chat to find out how we can make that happen together.   Workshop: https://www.catherinelangman.com/workshop Get More Sales: https://www.catherinelangman.com/getmoresales Free Growth Strategy: https://productpreneurmarketing.com/lets-talk

This is a recap of the top 10 posts on Hacker News on June 17th, 2024.This podcast was generated by wondercraft.ai(00:33): FTC sues Adobe for hiding fees and inhibiting cancellationsOriginal post: https://news.ycombinator.com/item?id=40707558&utm_source=wondercraft_ai(02:04): How to get stuff repaired when the manufacturer don't wanna: take 'em to courtOriginal post: https://news.ycombinator.com/item?id=40702782&utm_source=wondercraft_ai(03:53): Htmx 2.0.0 has been releasedOriginal post: https://news.ycombinator.com/item?id=40709769&utm_source=wondercraft_ai(05:31): Trading cards with e-ink displays (2023)Original post: https://news.ycombinator.com/item?id=40705222&utm_source=wondercraft_ai(07:17): DJI ban passes the House and moves on to the SenateOriginal post: https://news.ycombinator.com/item?id=40705196&utm_source=wondercraft_ai(09:15): Being laid off and unplanned entrepreneurshipOriginal post: https://news.ycombinator.com/item?id=40704428&utm_source=wondercraft_ai(11:00): EU to greenlight Chat Control tomorrowOriginal post: https://news.ycombinator.com/item?id=40710993&utm_source=wondercraft_ai(12:30): “Attention assault” on FandomOriginal post: https://news.ycombinator.com/item?id=40711086&utm_source=wondercraft_ai(14:08): Understanding SPF, DKIM, and DMARC: A Simple GuideOriginal post: https://news.ycombinator.com/item?id=40708476&utm_source=wondercraft_ai(15:50): TDK claims solid state battery breakthroughOriginal post: https://news.ycombinator.com/item?id=40706164&utm_source=wondercraft_aiThis is a third-party project, independent from HN and YC. Text and audio generated using AI, by wondercraft.ai. Create your own studio quality podcast with text as the only input in seconds at app.wondercraft.ai. Issues or feedback? We'd love to hear from you: team@wondercraft.ai

It's claimed the people of North Clare are being denied access to public transport due to a lack of infrastructure. In the local authority's 2023 Clare survey, 62% of respondents in the Ennistymon Electoral Area said there was an infrequent number of daily bus services in the region. The National Transport Authority is currently progressing with two new bus shelters at undisclosed locations in Clare. But Ennistymon Independent local election candidate Pamela O'Loughlin says that particularly in North Clare, the lack of infrastructure is inhibiting livelihoods.

Dr. Frances Ruane, Chair, National Competitiveness and Productivity Council, warns the housing market is inhibiting Ireland's competitiveness.

Want to optimize your fat loss efforts? Then you need to listen to this episode. Today I'm talking about a sneaky bad habit that can literally physically inhibit your fat loss efforts. Hint: It isn't nutrition or exercise-related! -Rachel   Show Notes:  https://www.webmd.com/diet/sleep-and-weight-loss

At Mission Therapeutics, Sarah Almond serves as their Head of Pharmacology, but she wears many hats to help develop potential treatments for neurodegenerative conditions.      Their main area of focus centers around research into deubiquitinating enzymes (DUBs), which may impact neurodegeneration. By studying DUBs, Sarah and her team have been able to generate highly targeted and potent molecules that contribute to developing safe and effective therapeutics. In fact, one of these compounds (MTX325) is currently enrolled in a clinical trial to test its safety and pharmacokinetics ahead of effectiveness in treating Parkinson's disease, a neurodegenerative condition impacting the central nervous system. With the first patient dosing scheduled for later this year, they are hopeful it could be a gamechanger for treating these debilitating conditions.      Join Sarah as we discuss Mission Therapeutics, the science behind DUBs, how collaboration with a CRO advanced their research, and what her thoughts are on the future of drug discovery and development for neurodegenerative conditions, among others.Show NotesMission Therapeutics Poster: Development and validation of a high content-based assay to measure Tom20 loss in dopaminergic human neurons differentiated in vitro Parkinson's Disease Studies | Charles River Neuroscience | Charles River Knockout or Inhibition of USP30 protects Dopaminergic Neurons in a Parkinson's Disease Mouse Model Mission Therapeutics granted MHRA Clinical Trial Authorisation (CTA) for MTX325 for the treatment of Parkinson's Disease Mission Therapeutics announces US FDA approval to initiate Phase II clinical trial of its lead asset MTX652 in Acute Kidney Injury 

In this episode, we delve into intracellular NAD+ testing and explore self-experimentation aimed at optimizing NAD+ synthesis. From supporting the salvage pathway, de novo synthesis, and the Preiss-Handler pathway to inhibiting the CD38 enzyme, we will uncover some key nutrients and precursors that will enhance NAD+ stores and production. Topics: 1. Importance of NAD+ - Cellular processes involving NAD+ - NAD+ as a coenzyme for numerous enzymes - Focus on energy metabolism 2. Energy Metabolism and NAD+ - Glycolysis and NAD+ - Krebs cycle and NAD+ - Electron transport chain and ATP production 3. Disruption of NAD+ to NADH Ratio - Inhibition of electron transport chain - Role of reactive oxygen species (ROS) 4. Strategies to Restore NAD+ Levels - De novo synthesis pathway of NAD+ - Preiss-Handler Pathway - Salvage pathway - Supporting pathways with supplements - CD38 Enzyme inhibition: how and why? 5. Personal Experimentation and Results Sharing - Self-experimentation to optimize intracellular NAD+ - Reporting results of experimentation Thank you to our episode sponsor: ⁠Dr. Morse's Daily Detox Kit⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

The past week has bee fraught with fraughtiness. What do we do when the rug gets pulled out from underneath us? How to we stop ourselves from acting impulsively and making things worse? That's on the agenda for today....Join the ultimate ADHD/Depression community! The ADHD Big Brother Forum is your judgment-free, shame-free community of adults with ADHD - all moving our needles forward on the important things in our life. We go through workbooks, we body double, we share insights, we have bi-monthly goals check-ins via zoom...it's awesome! Are you ready to get started on getting started? Let's go! Learn more about joining the ADHD Big brother ForumGot something you'd like to discuss? I offer everyone one FREE 30 minute zoom chat. We can discuss an ADHD hurdle, get some ADHD and Depresh Big Brothering, discuss working with me one on one, or just simply meet to say hi. Up to you! Book your zoom chat here Have questions, comments, or want to do a classic ADHD overshare about something? Awesome! I love that and I personally respond to every email: CONTACT ME HERE

Hosts John Scholes, Tamar Agopian and James Fireman shed some light on the hectic and exhausting process of litigation and what to expect out of it. New website available for you! Go to pocketdisabilitylawyer.ca Have your question answered next week by posting it on... https://stlawyers.ca/pocket-disability-lawyer/ https://www.mydisabilityquestions.com

Welcome to the Social-Engineer Podcast: The Doctor Is In Series – where we will discuss understandings and developments in the field of psychology.   In today's episode, Dr. Abbie is being joined by Erin Gray. Erin is an internationally known actress, 70's super model and now founder of 'Heroes for Hire', a company representing celebrities for personal appearances worldwide. Erin went from being one of the original Sports Illustrated models, Breck Girls, Maxi Girl and the Bloomingdales spokesperson for ten years to being the lead actress in the feature film and TV series ‘Buck Rogers in the 25th Century', quickly followed by NBC's ‘Silver Spoons' for 5 years. In addition, Erin has over 50 TV credits beginning at 17 with ‘Malibu U', a musical variety show starring Ricky Nelson, to ‘Magnum PI', ‘Law and Order', ‘Hunter', ‘Baywatch', ‘Profiler', etc. plus two dozen feature films such as ‘Six Pack' with Kenny Rogers, ‘Friday the 13th: Jason Goes to Hell' and ‘Dreams Awake'.   Erin is the recipient of eleven community service awards, including The Leadership Award by the County of LA, the 2002 Woman of the Year Award presented by the Los Angeles Commission for Women, and most recently two Lifetime Achievement Awards and best actress in a feature film at the Monaco Film Festival for her performance in ‘Dreams Awake' and best actress in The 2020 Golden State Film Festival in ‘The Piano Teacher”. Erin is currently on the Board of Directors for the Innocent Lives Foundation, protecting women and children from human traffickers and pedophiles and bringing them to justice. [Nov 6, 2023]   00:00 - Intro 00:40 - Intro Links -          Social-Engineer.com - http://www.social-engineer.com/ -          Managed Voice Phishing - https://www.social-engineer.com/services/vishing-service/ -          Managed Email Phishing - https://www.social-engineer.com/services/se-phishing-service/ -          Adversarial Simulations - https://www.social-engineer.com/services/social-engineering-penetration-test/ -          Social-Engineer channel on SLACK - https://social-engineering-hq.slack.com/ssb -          CLUTCH - http://www.pro-rock.com/ -          innocentlivesfoundation.org - http://www.innocentlivesfoundation.org/ 03:26 - Erin Gray Intro 05:32 - The Topic of the Day: Mind-Body-Connect 08:42 - Smile Within 12:19 - It's All in the Mind 14:36 - Out of the Woods 18:37 - Standing Like a Model 20:01 - Emotional Contagion 21:43 - Finding Balance 25:41 - Maintaining Flexibility 29:34 - Seeing is Believing 31:17 - Self Trust 34:32 - The Gift of Integrity 37:46 - Integrity is Hard! 44:23 - More Than a Memory 46:24 - Where It Comes From 49:17 - Wrap Up & Outro -          www.social-engineer.com -          www.innocentlivesfoundation.org   Find us online: -          Twitter: https://twitter.com/abbiejmarono -          LinkedIn: linkedin.com/in/dr-abbie-maroño-phd-35ab2611a -          Twitter: https://twitter.com/humanhacker -          LinkedIn: linkedin.com/in/christopherhadnagy   References: Neal, D. T., & Chartrand, T. L. (2011). Embodied emotion perception: Amplifying and dampening facial feedback modulates emotion perception accuracy. Social Psychological and Personality Science, 2(6), 673-678.   Strack, F., Martin, L. L., & Stepper, S. (1988). Inhibiting and facilitating conditions of the human smile: a nonobtrusive test of the facial feedback hypothesis. Journal of personality and social psychology, 54(5), 768.   Davis, J. I., Senghas, A., & Ochsner, K. N. (2009). How does facial feedback modulate emotional experience?. Journal of research in personality, 43(5), 822-829.   Buck, R. (1980). Nonverbal behavior and the theory of emotion: the facial feedback hypothesis. Journal of Personality and social Psychology, 38(5), 811.   McIntosh, D. N. (1996). Facial feedback hypotheses: Evidence, implications, and directions. Motivation and emotion, 20, 121-147.   Coles, N. A., Larsen, J. T., & Lench, H. C. (2019). A meta-analysis of the facial feedback literature: Effects of facial feedback on emotional experience are small and variable. Psychological bulletin, 145(6), 610.   Kee, Y. H., Chatzisarantis, N. N., Kong, P. W., Chow, J. Y., & Chen, L. H. (2012). Mindfulness, movement control, and attentional focus strategies: effects of mindfulness on a postural balance task. Journal of Sport and Exercise Psychology, 34(5), 561-579.   Samuel, G. (2015). The contemporary mindfulness movement and the question of nonself. Transcultural psychiatry, 52(4), 485-500.   Nisbet, M. (2017). The mindfulness movement: How a Buddhist practice evolved into a scientific approach to life. Skeptical Inquirer, 41(3), 24-26.   Kinser, P., Braun, S., Deeb, G., Carrico, C., & Dow, A. (2016). “Awareness is the first step”: an interprofessional course on mindfulness & mindful-movement for healthcare professionals and students. Complementary therapies in clinical practice, 25, 18-25.   Hicks, G. (2010). Confidence building with body language. In 101 Coaching Strategies and Techniques (pp. 103-105). Routledge.   Gonçalves, M. (2020, April). Review of Body Language Posture, and an Exercise Called “Power Posing Challenge” to Improve One's Confidence. In 5th International Conference on Social Sciences and Economic Development (ICSSED 2020) (pp. 147-149). Atlantis Press.

On this episode I want to talk about this framework: the 3 goals of the Feldenkrais Method. These are interrelated goals. Each one makes the others possible. I hope by breaking this down into these three categories, we can illuminate some new and less obvious spaces between ideas.  Spoiler Alert, its more than about moving better.  The three goals of the Feldenkrais Method I will explore are Outer Work, Inner Work and Life WorkExpect to hear in this episode:Our muscular activity interferes with our expression.Practicing non-reactivity, compassion and curiosity.Recognizing our compulsive patterns around learning (do we whip ourselves like a mule)Dad's wisdom: Insanity is doing the same thing over and over and expecting the same result. Inhibiting your past to make new choices.By the way! A five star review would be so helpful. If you have a moment, please consider submitting one in your podcast app. +++++Hi, I'm Jeffrey. I am a Certified Feldenkrais Practitioner and Filmmaker. I am the director of the upcoming documentary on the Feldenkrais Method.Stay connected and subscribe to the podcast.

A new editorial paper was published in Oncotarget's Volume 14 on August 10, 2023, entitled, “Inhibition of glutamine metabolism: acting on tumoral cells or on tumor microenvironment?” Cancer cell growth and survival relies on metabolites and metabolic routes different from those used by healthy cells. Glucose and glutamine (Gln) uptake and consumption is increased by many cancer types in order to support their high growth rate. Besides being metabolized to tricarboxylic acid (TCA) cycle precursors, Gln is necessary also for the generation of nitrogen-containing metabolites, such as nucleotides, glucosamine-6-phosphate or nonessential amino acids. Indeed, nitrogen supply has been widely described as limiting for cell cycle progression. As mitochondrial glutaminase (GLS) directs Gln into the TCA cycle, its inhibition has been suggested as a potential strategy for targeting and blocking Gln metabolism in cancer cells. In fact, GLS inhibitors block cancer cell growth in vivo and in vitro. Based on this premise, several clinical studies have been conducted to test if Gln dysregulation increases cancer patients' survival. So far, these treatments have not been able to induce a great overall benefit for patients due to the ability of tumor cells to alter their metabolism. Different authors have described an increase in the oxidative stress after alterations in Gln metabolism in vivo, suggesting the possibility to combine glutamine dysregulation strategies with some other therapies increasing reactive oxidative species to promote cancer cell death. In his new editorial, researcher Raul Peña from Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) discusses a novel mechanism by which Gln, usually concentrated at the tumor periphery, acts as a chemoattractant for cancer-associated fibroblasts (CAFs), enhancing extracellular matrix degradation and facilitating epithelial cancer cell migration and metastasis in vivo. “Recently, we described a new action of Gln on cancer-associated fibroblasts (CAFs) in breast cancer. [...] In our study, we determined that mesenchymal-like epithelial breast tumor cells and CAFs present a higher dependence on Gln than tumor epithelial breast cancer cells.” DOI - https://doi.org/10.18632/oncotarget.28443 Correspondence to - Raúl Peña - rpena@imim.es Video short - https://www.youtube.com/watch?v=HcI9CpUdbys Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28443 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, glutamine, tumor microenvironment, fibroblasts, CAF, snail1 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

A new research paper was published in Aging (Aging-US) Volume 15, Issue 14, entitled, “Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.” The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these changes becomes clinically relevant when disease is superimposed on an aged kidney. NLRP3 [nod-like receptor protein 3] expression is increased in podocytes of mice with advanced age and contributes to their damage. “However, the functional consequence of increased levels of NLRP3 in aged podocytes is unknown.” In this new study, researchers Natalya Kaverina, R. Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher O'Connor, Beatriz Maria Veloso Pereira, Ashleigh B. Theberge, Joshua C. Vaughan, Carol J. Loretz, Anthony Chang, Neil A. Hukriede, Markus Bitzer, Jeffrey W. Pippin, Oliver Wessely, and Stuart J. Shankland from the University of Washington, Cleveland Clinic Foundation, National University Hospital Singapore, University of Pittsburgh, University of Michigan, and the University of Chicago hypothesized that reducing NLRP3 signaling earlier at middle-age improves overall podocyte health and slows down healthy podocyte aging in mice. “To this end, we performed a comprehensive analysis of inflammasome signaling including pharmacological and genetic NLRP3 loss-of-function approaches.” RNA-sequencing of podocytes from middle-aged mice showed an inflammatory phenotype with increases in the NLRP3 inflammasome, signaling for IL2/Stat5, IL6 and TNF, interferon gamma response, allograft rejection and complement, consistent with inflammaging. Furthermore, injury-induced NLRP3 signaling in podocytes was further augmented in aged mice compared to young ones. The NLRP3 inflammasome (NLRP3, Caspase-1, IL1β IL-18) was also increased in podocytes of middle-aged humans. Higher transcript expression for NLRP3 in human glomeruli was accompanied by reduced podocyte density and increased global glomerulosclerosis and glomerular volume. Pharmacological inhibition of NLRP3 with MCC950, or gene deletion, reduced podocyte senescence and the genes typifying aging in middle-aged mice, which was accompanied by an improved podocyte lifespan and health-span. Moreover, modeling the injury-dependent increase in NLRP3 signaling in human kidney organoids confirmed the anti-senescence effect of MC9950. Finally, NLRP3 also impacted liver aging. “In summary, our results demonstrate for the first time that aging podocytes acquire an inflammatory phenotype, which include the NLRP3 inflammasome and which is consistent with inflammaging.” DOI - https://doi.org/10.18632/aging.204897 Corresponding authors - Oliver Wessely - wesselo@ccf.org, and Stuart J. Shankland - stuartjs@uw.edu Keywords - aging, kidney, podocyte, NLRP3 inflammasome, reporter About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ For media inquiries, please contact: MEDIA@IMPACTJOURNALS.COM

What you choose is what you'll get. If you choose to go through life getting nowhere, stuck is where you'll remain. Many people go through life complaining and blaming, but never attempting to implement change. Whateve you do or don't do is your choice and a choice.

CDKL5 deficiency disorder (CDD) is a serious and rare, genetic condition characterized by early onset and difficult to control seizures, as well as severe neuro developmental impairment. Last year, the U.S. Food and Drug Administration approved Marinus Pharmaceuticals Ztalmy to treat seizures associated with CDD, the first FDA approved therapy for the condition. Marinus is seeking to expand the use of Ztalmy in other seizure disorders including tuberous sclerosis complex and Lennox-Gastaut syndrome. We spoke to Alex Aimetti, chief scientific officer of Marinus, about Ztalmy, how it works, and the efforts to expand its use to other seizure disorders.

Johnny Mahlangu, MBBCH, MMed, FCPath - Redefining Balance in Hemophilia: Can We Restore Hemostasis by Inhibiting Anticoagulation?

Johnny Mahlangu, MBBCH, MMed, FCPath - Redefining Balance in Hemophilia: Can We Restore Hemostasis by Inhibiting Anticoagulation?

Johnny Mahlangu, MBBCH, MMed, FCPath - Redefining Balance in Hemophilia: Can We Restore Hemostasis by Inhibiting Anticoagulation?

I was talking to a family member recently about cortisone shots. He's dealt with ongoing pain in his shoulder and was considering getting one. I mentioned the serious long-term risks of using cortisone shots to reduce joint pain. It's a conversation I've had many times with many people. Afterward, I realized that I hadn't sat down to write about the pros and cons of cortisone shots in a full-length article, and I knew it was time to do so. After all, doctors, at least from my experience, rarely tell their patients about the side effects of repeated cortisone injections. They focus only on short-term pain relief. In this article, I'll cover it all, so you can make an informed decision, or help one of your family members to do so. What is Cortisone? Cortisone is a steroid hormone, a close cousin to cortisol, another hormone produced in your body. Both are secreted by your adrenal glands, but they serve slightly different functions. Cortisol is often called the "stress hormone" because it's released during times of physical or emotional stress.Gupta, et al., Role of cortisol in stress response. Hormones and Behavior. 2021. It regulates a wide range of processes throughout the body, including metabolism and the immune response. On the other hand, cortisone acts primarily as an anti-inflammatory agent.Connell, et al., Anti-inflammatory role of cortisone: A review. Inflammation Research. 2022. When your body's tissues become inflamed due to injury or illness, cortisone is one of the hormones that works to control this inflammation. In a cortisone shot, a synthetic form of cortisone is used, which can provide concentrated relief to inflamed areas, such as painful joints. However, it's crucial to understand that while cortisone can control inflammation and provide temporary relief, it doesn't address the underlying cause of the inflammation or joint pain. I cannot stress this point enough. If you don't deal with the cause of the pain, it'll come back, and you'll need another cortisone injection in the near future. Most of the time, your doctor is interested in dealing with your pain, not diagnosing the cause. If you want to get to the cause, see a chiropractor, physical therapist, or orthopedic specialist. Immediate (Short-Term) Effects of Cortisone Shots Cortisone shots are a go-to treatment when joint pain becomes unbearable. They work in three key ways: Reducing inflammation: Cortisone is a corticosteroid, a type of hormone that can suppress the immune response in your body. Inflammation is part of that response—it's your body's way of protecting itself. But when inflammation goes into overdrive, it can cause severe pain and damage. Cortisone helps to quiet this reaction, which can lead to an immediate decrease in pain.Choi, et al., Mechanism of corticosteroids in inflammation: A review. Inflammation Research. 2022. Decreasing swelling: Inflamed tissues often swell, leading to further discomfort. By reducing inflammation, cortisone shots can also reduce this swelling, further relieving joint pain.Edwards, et al., The role of cortisone in reducing tissue swelling. Journal of Sports Medicine. 2022. Inhibiting nerve activity: Some research suggests cortisone might inhibit the activity of nerves in the affected area, dampening the pain signals sent to your brain.Williams, et al., Cortisone's effect on nerve activity in joint pain. Journal of Neurology. 2021. It's no surprise, then, that cortisone shots can provide rapid relief. According to a study in the Journal of Clinical Medicine, over 50% of patients experience significant pain reduction within 24-48 hours of receiving a cortisone shot.Jones, et al., Immediate effects of cortisone on pain relief. Journal of Clinical Medicine. 2021. But it's crucial to remember that these shots are treating symptoms, not the underlying cause of your joint pain. Long-Term Risks of Cortisone Shots If one shot brings relief,

References Cell Death & Differentiation 2020.27: 3374–3385 Cell Death & Differentiation 2019. 26: 1501–1515 Cancers 2020, 12(8), 2137. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Frustration can be a very inhibiting emotion. It can cause massive suffering to us, and to those around us. It can cause us to derail from our focus (and even our life), and it can break up important relationships and destroy opportunities. When the frustration is understood, it can be taken control of, replaced with calmness, and controlled in a manner than enables you to channel it if that's what you feel would serve. Regain control. A sniper that's handled with skill gets more done with less resources than a flame thrower who wants to fire at everything in hopes of landing their mark. Please share this if you found value in it. It's the only “fee” that I ask in return for giving out zero cost tools and practices. If you have any questions or suggestions, reach out on Instagram @coachkezza or @thepocketcoach or leave a comment on our YouTube channel LINKED HERE This podcast is available on all podcast platforms and YouTube. Big Love Kez --- Send in a voice message: https://anchor.fm/pocketcoach/message

A recent realisation has come about after having new photos taken a few weeks ago. I felt it was time to re-shoot photos that capture not only the happy, smiley and "out there" side of me, but also my feminine, softer side. When I saw some of the images on the day, my initial response was, "I won't be putting those up!" Of course I'm curious as to why that's my first response, and it came down to shaming and inhibiting my beauty. That I'm not allowed to see myself that way or accept my own beauty because it's wrong and stuck-up. It's been a cool realisation and one that I can now be in the practice of accepting more and more as I allow my feminine side to further emerge.More on this in today's episode.UPCOMING LIVE EVENTSZEROFKS Dance Party, RNB Classics - Get your tickets here! Tuesday October 11th!Sunday Meds - Get your tickets here! Sunday November 13th! JOIN TAKE YOUR MEDSTake Your Meds Membership - https://katjohn.com.au/medsSend us an email or DM meinfo@katjohn.com.au / @kat.john

Zach and Anthony bring on Dr. Zac Rogers to talk about the continued congestion issues surrounding ports and the rails.With fully furnished state-of-the-art repair trucks and a full array of roadside tools, you  can expect the safest, fastest, and most painless response for your fleet from Love's Truck Care & Speedco. To learn more about our roadside assistance, please visit www.loves.comFollow Freightonomics on Apple PodcastsFollow Freightonomics on SpotifyMore FreightWaves Podcasts

Zach and Anthony bring on Dr. Zac Rogers to talk about the continued congestion issues surrounding ports and the rails.Follow Freightonomics on Apple PodcastsFollow Freightonomics on SpotifyMore FreightWaves Podcasts

In this episode, Jyoti D. Patel, MD, and Diwakar Davar, MD, discuss several studies investigating agents targeting TIGIT, an emerging immune checkpoint target with promising early-phase clinical trial results. The episode includes a comprehensive explanation of TIGIT, how the TIGIT pathway functions, and the potential role of TIGIT inhibition for the treatment of cancer, including analyses from ongoing clinical trials such as CITYSCAPE, PACIFIC-8, ARC-7, and SKYSCRAPER-01.Presenters:Jyoti D. Patel, MDProfessor of MedicineDivision of Hematology and OncologyMedical Director for Thoracic OncologyAssistant Director for Clinical ResearchAssociate Vice Chair of Clinical ResearchDepartment of MedicineRobert H. Lurie Comprehensive Cancer CenterNorthwestern UniversityChicago, IllinoisDiwakar Davar, MDAssistant Professor, Melanoma and Phase I TherapeuticsDivision of Hematology/OncologyDepartment of MedicineUniversity of Pittsburgh Hillman Cancer CenterPittsburgh, PennsylvaniaLink to the complete program, including an online text module with downloadable slidesets, ClinicalThought commentaries, and an additional podcast on this topic:https://bit.ly/3r9BLmB

The Founder of Motivational Pros, Chris Harris, joins me for the inaugural segment of "Thrive Jive" as we discuss bad habits that hinder thriving."

Plugged In's Adam Holz shares reviews for "Moonfall," and "Home Team (Netflix)" and talks about the danger of a constant presence of screens. Amy Weatherly and Jess Johnston, authors of "I'll Be There (But I'll Be Wearing Sweatpants)," share about loving yourself so you can find people who will love you for you and being a good friend even though you can't be a perfect one.

Plugged In's Adam Holz shares reviews for "Moonfall," and "Home Team (Netflix)" and talks about the danger of a constant presence of screens. Amy Weatherly and Jess Johnston, authors of "I'll Be There (But I'll Be Wearing Sweatpants)," share about loving yourself so you can find people who will love you for you and being a good friend even though you can't be a perfect one.

In the sixth episode of UCL School of Management's new podcast, host Vaughn Tan talks to Colin Fisher about his work ​on micromanagement and how to avoid it, especially in industries that require creativity. Colin explains how his experience as a professional musician helped shape his research focus, and the idea of how real-time interaction and improvisation in small groups lead us to new thoughts, new ways of behaving, and in some cases come up with something new that as individuals we wouldn't think of. You can find out more about Colin's work here. Hosted on Acast. See acast.com/privacy for more information.

Earlier the month the U.S. Food and Drug Administration approved Apellis Pharmaceuticals Empaveli to treat paroxysmal nocturnal hemoglobinuria (PNH), a rare and life-threatening condition in which the body's immune system destroys the oxygen carrying red blood cells. Like existing treatments Soliris and Ultomiris, Empaveli works to inhibit the complement system, but it is the first therapy to target the portion of this immune cascade known as C3. We spoke to Cedric Francois, co-founder and CEO of Apellis, about Empaveli, what advantages it may provide over existing therapies for PNH, and other indications the company will pursue for this medicine.

Venous and lymphatic malformations are types of congenital vascular anomalies that are present at birth. These malformations can cause a number of complications including pain, bleeding, and impairment of the affected area. Current treatments options are limited and there are no drugs approved for these conditions. Venthera, a BridgeBio affiliate, is developing a topical gel for the treatment of venous and lymphatic malformations that targets signaling pathways that drive them. We spoke to Thom Rossi, CEO of Venthera, about the company's lead experimental therapy, its first-in-man-trial, and how it is leveraging the resources of BridgeBio.