Podcasts about inhibiting

Show Notes:Hello and welcome to Authentically ADHD – I'm Carmen, and I'm so glad you're tuning in. Today we're exploring a topic I know many of us grapple with: why you're still exhausted even after resting, especially when you're both autistic and ADHD (often called AuDHD). If you've ever wondered, “I took a break, so why do I still feel drained?” this episode is for you.We often hear about the idea of a “social battery.” The classic metaphor goes like this: social time drains you, alone time or rest recharges you, then you're good to go again. It's a handy way to explain why you might feel wiped out after a party or a day of meetings – you used up your social battery and need some quiet time to recharge. For neurotypical folks or even just introverts, that simple formula sometimes works: hang out with people (battery drains), spend a night in (battery refills), and you're refreshed.But if you're neurodivergent – and especially if you're AuDHD (autistic + ADHD) – you've probably noticed it's not that simple. You might spend a weekend resting at home only to wake up on Monday still bone-tired. Or you take a day off to recharge, and by evening you're more exhausted than before. What gives? In today's episode, we're going to answer that. We'll talk about why the one-dimensional social battery metaphor doesn't fully capture what's happening in our brains and bodies. We'll dive into the neuroscience behind exhaustion in autism and ADHD: it's not just being “peopled out” – it's also things like masking, sensory overload, executive function fatigue, chronic stress mode, and even missed signals from our own bodies.By understanding these factors, we can start to make sense of why just “resting” isn't always enough for us. Importantly, we'll discuss what real rest means for an AuDHD brain. I'll share some strategies and tips on how to recharge the right way (because if your rest isn't targeting the actual type of tired you are, it's not going to truly restore you). And be sure to stick around till the end – I have 7 reflection questions for you. These will help you apply what we talk about to your own life, so you can figure out what drains your energy and how to refill your tank more effectively.So, grab a comfy seat, maybe a notebook, and let's unpack why you're still exhausted after rest – and what we can do about it.The Classic “Social Battery” Metaphor – And Its LimitsLet's start with that “social battery” idea. It's a popular way to describe energy levels, especially for introverts. The idea is pretty straightforward: social interaction uses energy, and solitude or downtime charges you back up. For example, if you spend all day socializing with coworkers or attending events, you might feel drained – your social battery is empty. Then you recharge by being alone, watching Netflix, reading, sleeping, what have you. The next day, your battery is full again (or at least partially recharged) and you repeat the cycle.This metaphor resonates because it acknowledges that socializing can be tiring, even if it's fun. It's commonly mentioned for conditions like ADHD or just shy/introverted personalities: “I need to recharge my social battery.” For neurotypical people, often a good night's sleep or a quiet Sunday morning might indeed restore that sense of energy.But here's the catch: the social battery model assumes only one dimension of fatigue – social energy in versus out. It treats all “rest” as equal, like plugging your phone into any charger will top it off. For those of us with ADHD, autism, or both (AuDHD), our experience tells a more complex story. We don't just have a single battery that drains and refills; we have an entire panel of batteries or fuel tanks, each for different kinds of energy. Sometimes you're not even sure which battery is low – you just know you're running on fumes. And crucially, if you try to recharge in the wrong way, it's like putting the wrong fuel in a car: you don't get very far, and you might even stall out.Have you ever tried to rest – say you cleared your weekend to do nothing – and you did all the “right” restful things like sleeping in or binging a show, but you still felt wiped out on Monday? I've been there. Before I understood the multiple dimensions of burnout, I would get frustrated at myself: “I rested, why am I still tired? What's wrong with me?” The social battery idea would have me believe that rest = recharge, so if I rested and I'm still tired, I must be doing something wrong. But the truth was, my rest wasn't actually addressing the kind of exhaustion I had.The classic metaphor doesn't account for things like:Mental overload – maybe your mind was exhausted from racing thoughts or decision-making, but your “rest” didn't quiet your mind.Sensory overload – maybe your senses were still on high alert from a noisy, bright, chaotic week, and watching TV on the couch kept bombarding you with light and sound.Emotional strain – maybe you were carrying stress or anxiety (perhaps from masking your true self or holding in emotions), and “resting” by doing nothing didn't process those feelings.Physical fatigue – maybe your body needed real recovery (nutrition, hydration, movement or sleep), but your rest was just lying around without addressing those needs.Executive function fatigue – perhaps you spent all week forcing your ADHD brain to stay organized and on-task, which is extremely draining, and simply taking time off work didn't automatically replenish that mental fuel.In other words, neurodivergent exhaustion is multi-faceted, and the social battery idea is just one piece of the puzzle. For AuDHD folks, social interaction itself can be exhausting, yes, but why it's exhausting goes beyond just “I don't like being around people too long.” There are underlying factors – neurological and physiological – that make social settings or daily life in general more draining for us than for others. Let's break down those factors.Why AuDHD Exhaustion Is More Than “Just Social”When you have autism, ADHD, or both, several concurrent processes are depleting your energy throughout the day. It's like having multiple apps running on your mental phone battery. If we ignore all but one, we miss the full picture. Here are some of the big drains on an AuDHD “battery”:1. The Masking Labor – Hidden Exhaustion of “Acting Normal”Masking refers to hiding or suppressing your natural neurodivergent behaviors to fit into a neurotypical world. Think of it as a social survival strategy: you force yourself to maintain eye contact even though it's uncomfortable, you hold back your stims (like fidgeting or rocking) to seem “calm,” you laugh when you're supposed to even if you're confused, you constantly monitor your tone and words so you don't offend or seem weird. Basically, you're running a mental filter 24/7 to appear “normal.” That is hard work!For autistic people especially, masking can be an enormous cognitive and emotional load. It's not just casually wearing a “social face”; it's more like performing a play where you're the actor and the director, constantly watching yourself from the outside. For ADHD folks, masking might involve holding back your impulsive comments, forcing yourself to sit still and appear attentive, or over-preparing for conversations so you don't lose track.All this mental multitasking consumes a ton of energy. Imagine your brain as a computer running several heavy programs at once – eventually it's going to lag or overheat. When you're masking, you might be:Analyzing every social cue and your own reactions (“Am I smiling enough? Did that joke land? Do I seem interested?”).Inhibiting natural impulses (“Don't stim, don't interrupt, don't pace even though I'm restless…”).Translating your intended words into more “acceptable” phrases.Absorbing the stress of not being able to relax or be yourself.No wonder by the time you get home from work or a social gathering, you feel like you ran a marathon (even if all you did was sit in a conference room or a cafe). Masking is exhausting. It's often described as wearing a heavy costume all day; when you finally take it off, you might physically collapse. This is a huge reason your “social battery” drains so fast and stays low: you weren't just socializing, you were performing and self-censoring nonstop.2. Sensory Processing Load – When the World Overwhelms Your SensesMany autistic and ADHD individuals experience sensory sensitivities. This means ordinary environments can feel like an assault on your nervous system. The lights in a grocery store are glaring and fluorescent, the chatter at a party is a jumble of noise, the fabric of your shirt tag is scratching your neck all day – these might barely register for a neurotypical person, but for us, they can be intensely distracting or irritating.Your brain is constantly processing sensory input: sight, sound, touch, smell, movement, etc. In neurotypical brains, there's a filter – they can often tune out background noise or adapt quickly to stimuli. In an AuDHD brain, that filter may be weaker or just different. Everything comes in at full volume, so to speak. As a result, you're expending energy just to exist in what others call a “normal” environment. You might not realize how much work your brain is doing to process and cope with the sensory avalanche until you find yourself utterly drained for “no obvious reason.”It's not just mentally tiring; it activates your physiology. When you're in sensory overload, your body can go into a mild fight-or-flight state. Think about being startled by a sudden loud noise – your heart jumps, adrenaline spikes. Now imagine smaller scale but chronic versions of that throughout your day: the phone ringing, the traffic noise, the uncomfortable chair, the strong perfume in the elevator. Your body might be perpetually a little on edge. Stress hormones like cortisol and adrenaline might be slightly elevated as your system says “too much, too much!” Even if you consciously try to ignore a chaotic environment, your nervous system is still reacting. Over time, living in that amped-up state will wear you out.So if you spend a day in a noisy, busy setting (say, an open-plan office or a crowded mall), you might come home utterly spent. And here's the kicker – if your idea of “rest” is, say, plopping on the couch with the TV on, you might not actually be giving your sensory system a break. The TV is still light and sound. Your phone screen is still input. If sensory overload was a big part of your energy drain, you need sensory rest: dim lighting, silence or calm music, maybe a weighted blanket or whatever soothes your senses. Without addressing that, a quiet night might only pause the overload without truly clearing it, leaving you still jittery or frazzled the next day.3. Executive Function Taxes – Paying the “Brain Tax” on Every TaskExecutive function is like the brain's management system – it covers things like planning, organizing, focusing, remembering details, switching tasks, and controlling impulses. Both ADHD and autism can come with executive function challenges (though they might show up differently). For ADHD in particular, things like staying focused, following steps, meeting deadlines, and making decisions can require intense conscious effort. It's not that we can't do them – we often can, but it's like driving with the parking brake on. We have to press the gas harder to go the same distance.Studies have found that adults with ADHD use up more mental energy throughout the day just managing routine tasks. One psychologist described it well: people with ADHD exert greater effort on everyday decisions and self-control, which “burns up mental fuel” at a faster rate than neurotypicals. Have you ever felt strangely tired after doing “nothing” except answer emails or make a few simple phone calls? That could be because for an ADHD brain, shifting attention between those emails, resisting the urge to check social media, remembering what you had to do next, all of that took a lot of invisible effort.Autistic folks, on the other hand, might get mentally drained from tasks like navigating transitions (shifting from one activity to another can be jarring) or dealing with unpredictability without a clear plan. Planning and adapting – those executive functions – can take a lot of conscious processing if your brain doesn't do it automatically.All day long, we're essentially paying an “executive function tax.” Every time you force yourself to concentrate on a boring task, every time you have to break down a project into steps, every time you coach yourself through procrastination or try to remember an appointment – that's a withdrawal from your cognitive energy reserves. By evening, you've been taxing that system so heavily that you might experience brain fog, trouble concentrating, or an inability to make even trivial decisions (“decision fatigue” – like staring at the fridge unable to decide on dinner).If your rest doesn't give your executive brain a break – for example, if you “rest” by doing something mentally complex like reading dense articles or doing a puzzle when your mind was what was exhausted – you may not feel recovered. Sometimes what we need is true mental rest: no complex planning, maybe even a break from screens and information intake, letting our thoughts wander or doing a mindless simple activity. Without identifying that need, you might mistakenly think “I just need more sleep,” but eight hours later you still wake up mentally exhausted, because your mind never got a break from overdrive.4. Stress-System Activation – Living in Fight-or-Flight ModeThis one underpins all the above: chronic stress. Both living with ADHD and autism can be chronically stressful, even if you love your life and manage well. There's the stress of trying to meet neurotypical expectations, the stress of sensory assault, the stress of potential social missteps or failures at work, and often a history of anxiety or trauma from not being understood. All this means our sympathetic nervous system (the fight-or-flight responder) might be activated more often or more intensely.Physiologically, when you perceive a challenge or threat (and “challenge” can be as mundane as the boss unexpectedly asking you a question, or a sudden loud noise that startles you), your body releases hormones like adrenaline and cortisol. Your heart rate might go up, blood pressure increases, senses heighten. It's your body's way of gearing up to face something. That's fine in short bursts, but if it's happening repeatedly through the day, you don't get much time in the restorative, relaxed state (the parasympathetic “rest and digest” mode).Being constantly in a subtle fight-or-flight mode is exhausting. It also affects sleep and energy recovery. For instance, if your stress system is always a bit activated, you might have trouble winding down at night or you might not get deep, quality sleep. You could sleep a full night and still wake up tired because physiologically, your body hasn't truly relaxed. Chronic stress can also mess with things like muscle tension (ever realize you've been clenching your jaw or shoulders all day?), digestion, and immune function – which can all indirectly make you feel more fatigued and rundown.For AuDHD people, stress might be coming from multiple angles: social anxiety, ADHD-related worries (“Did I forget something important again?”), sensory stress, or just the general pressure of appearing fine while you're actually struggling. Even exciting positive things can register as stress to the body – like hyperfocus or sensory excitement can amp you up similar to anxiety. So if you're constantly running “hot” internally, you need cooling-off periods. If your rest doesn't include something that actually calms your nervous system – like deep breathing, mindfulness, gentle movement, a safe feeling environment – you might stay in a semi-stressed state even during downtime. That means your “battery” isn't recharging; at best, you're just not draining it further for a while.5. Interoception Glitches – Missing Your Body's Early Warning SignalsInteroception is a fancy word for the internal sense of your body's condition – basically, feeling your own internal signals like hunger, thirst, tiredness, pain, needing the bathroom, etc. Many autistic people (and some ADHD folks too) have differences or delays in interoception. This can mean you don't notice your needs until they're screaming at you.Think about times you suddenly realize, “Oh my gosh, I'm starving – I haven't eaten in 8 hours!” or you're shivering and only then notice you're cold. Or you're so deeply focused on a project (thanks hyperfocus) that you don't realize you're exhausted until you stand up and almost fall over. That's interoceptive unawareness – our internal “fuel gauge” is not very accurate.For an AuDHD person, this might lead to literally running on fumes. You might be extremely low on energy but not fully register it until you hit a wall (like a shutdown or a meltdown or just a sudden wave of exhaustion that knocks you out). Likewise, you might not identify what kind of rest you need. You just feel “bad” or “tired” or “crappy” but can't tell if it's because you're dehydrated, or overstimulated, or emotionally upset. So you might try the wrong fix. For example:You feel out of it, so you assume you need a nap. But maybe what you needed was actually food and water (physical need), so you wake up from the nap still feeling off.Or you feel “tired” but actually you've been sitting indoors all day and your body is under-stimulated physically and craving movement (some ADHDers know the feeling of being lethargic from lack of activity). If you just lie down more, you feel even worse, whereas a short walk or some stretches might have rejuvenated you.Or you feel mentally drained and foggy, so you try to push through with caffeine and working more, when actually your brain desperately needed a break from screens and information (mental rest).When interoception isn't giving clear signals, it's easy to mis-match our rest to our need. We also tend to wait too long to address our needs. It's like driving your car until the fuel light is not just on, but the tank is nearly empty and the car is sputtering – then you pull into a random gas station and try to fill up without knowing what type of fuel you needed. If you put diesel in a gasoline engine, the car's not going to run, right? Similarly, if you try a form of “rest” that isn't what your body or brain actually require, you won't feel better. You might get a brief pause, but not true recovery.This can become a vicious cycle: you rest ineffectively, still feel exhausted, maybe even more frustrated (“I rested and it didn't help, why bother?”), and then you push yourself further next time, edging closer to burnout.So, to sum up this section: the social battery is more complicated for AuDHD folks because multiple systems are draining your energy – social interaction plus masking, sensory processing, executive function, stress responses, and trouble noticing your needs. It's like having five batteries in parallel, and when you say “I'm drained,” it could be one or all of them that are empty. If you only recharge one, the others might still be flashing red.Now that we understand why you might still feel exhausted after what you thought was adequate rest, let's talk about the science and physiology a bit more, and then we'll move on to strategies for tackling this in real life.The Physiology Behind AuDHD ExhaustionYou might be wondering, “Okay, so these different drains make sense, but what's actually happening in my body? Is this all in my head or is there a real physical basis for why I'm so wiped out?” It's very real, and neuroscience and physiology back it up. Let's take a peek under the hood of the AuDHD body and brain when it comes to energy:Brain Energy and Cognitive Effort: The brain, even though it's just 2% of our body weight, uses a ton of energy – some estimates say about 20% of our daily calories. When you're engaging in heavy cognitive effort (like constant self-control, focus, or social navigation), you're burning through glucose (sugar energy) in the brain at a faster rate. Neurotypical brains might solve a problem or engage in small talk using X amount of energy. An ADHD or autistic brain might need 2X because it's working harder to stay on track or decode the social nuances. Over a day, that adds up. By late afternoon, you might literally be low on brain fuel, which is why you experience that heavy fatigue or brain fog. It's not just mood or laziness – it can be a sign your brain's resources are depleted.Dopamine and Neurotransmitters: ADHD is associated with differences in dopamine regulation – dopamine is a neurotransmitter important for motivation, focus, and reward. If your brain has a dopamine deficit in certain circuits, tasks don't reward your brain as much, so you have to push yourself harder to do them. It's kind of like driving a car with low battery – you can do it, but it might sputter. This not only makes tasks feel harder mentally, it also can lead to a sort of constant seeking of stimulation to get that dopamine hit (hello, checking our phones or daydreaming), which itself can be tiring. Meanwhile, autistic brains often have different connectivity patterns – some areas might be hyper-connected, leading to intense focus or sensory awareness, while other regulatory circuits might be less connected, making switching tasks or filtering input harder. The result? A brain that's either revving high or working overtime to shift gears. These neurological differences mean that an AuDHD brain is often running rich (like an engine burning a lot of fuel) all day.Hormones: Cortisol and Adrenaline: I touched on this earlier – the stress hormones. Cortisol is known as the “stress hormone” that follows a circadian rhythm (should be high in morning, low at night) and spikes during stress. Chronic high cortisol from frequent stress can cause fatigue, brain fog, and even body aches. Adrenaline (epinephrine) is more immediate – it gives you that jolt in emergencies. If you're frequently anxious or overstimulated, your adrenaline might spike often, and afterwards you typically feel a crash – shaky, tired, maybe headachey. Some of us live in a pattern of mini adrenaline spikes throughout the day (panic about a task deadline, sensory shock from a siren, social anxiety spike when your phone rings…). Over time, this wears you down and can dysregulate your whole energy system. Your body might start overreacting or underreacting to stress due to burnout of the stress response system. This is why managing stress and actually engaging the relaxation response (like deep breathing to trigger the vagus nerve, which can lower heart rate and cortisol) is so key. Physically calming your body is not just woo-woo; it's helping your hormones rebalance so you can truly recharge.Muscle Tension and Physical Load: Ever notice how when you're mentally stressed, your body feels sore or tired? If you have anxiety or are masking, you might be unconsciously tensing muscles – clenching your jaw, hunching shoulders, or tapping your foot all day. Autistic folks might suppress stims which actually takes muscle control. ADHDers might be restraining their urge to move. All this can lead to physical exhaustion and even pain by day's end. Plus, conditions often co-occurring with AuDHD – like hypermobility, sleep disturbances, or digestive issues – can further sap physical energy.Sleep Quality: Many of us with ADHD or autism have sleep issues – trouble falling asleep, staying asleep, or not feeling rested from sleep. Neurologically, if your brain has trouble shutting off (common with ADHD racing thoughts or autism's difficulty unwinding routines), you might not get enough deep sleep. Sleep is when the brain and body repair. It's like plugging in your phone overnight – if you only charge to 50% or keep getting unplugged, you start the day at a deficit. Over days and weeks, that compounded sleep debt can make any amount of daytime rest feel ineffective. It's like trying to fill a bucket that has a leak at the bottom.In short, there are concrete brain and body reasons for your persistent exhaustion. You're not just “bad at resting” or “lazy” or “weak.” Your system is genuinely handling more and recovering less than the average person's. Knowing this is validating – it's not in your imagination. And importantly, it points toward solutions: for example, approaches that reduce the constant load on your brain (like accommodations or assistive tools for executive function), or practices that actively help your nervous system relax (like mindfulness, therapy, or sensory decompression activities).What AuDHD Exhaustion Looks Like in Daily LifeIt might be helpful to recognize how this kind of multi-faceted exhaustion shows up, because sometimes we don't even have the words for what we're feeling. We just know we're done. Here are some common signs that your various “batteries” are drained:Brain Fog and Zoning Out: You've had a day full of interactions and tasks, and now you just can't think straight. You find yourself staring at the wall or scrolling mindlessly because your brain refuses to focus on anything else. That's mental exhaustion – your brain is literally trying to power down for a bit. Autistic folks might experience shutdowns: where you go non-verbal or withdraw because your brain says “nope, I cannot engage anymore.” ADHD folks might find their attention just ricochets around or flatlines.Physical Fatigue and Aches: Your body might feel as if you ran a marathon, even if you didn't move much. Maybe your legs feel heavy, or you have a tension headache from hours of concentrating or from sensory stress (like squinting in bright light or bracing against loud noises). Chronic muscle tension can manifest as back or neck pain. Some people get stress-related fatigue where you feel flu-like (aching, low energy) purely from the cortisol rollercoaster.Irritability or Emotional Volatility: When we're running on empty, small things become big things. You might have a shorter fuse – maybe you snap at your partner or get teary over a minor issue. For AuDHD individuals, emotional regulation can already be a challenge (ADHD is often associated with big swings of feelings or what's called “Rejection Sensitive Dysphoria,” and autistic people can feel emotions intensely too). Exhaustion strips away the buffers we normally have. So that irritability, sadness, or anxiety that creeps in after a long day might actually be a symptom of fatigue. Think of little kids – when they're overtired, they have meltdowns over nothing. We adults are the same, we just mask it better until we can't.Avoidance and Withdrawal: You might cancel plans with people you actually like, or avoid a phone call from your best friend, simply because the thought of any interaction is overwhelming. This is often labeled the “social hangover.” After too much stimulation or masking, you might need to be alone, sometimes for days, to feel normal again. You might also pull away from work or responsibilities – like ignoring emails, procrastinating important tasks – not because you don't care, but because you just can't right now. Your system is forcing a shutdown of non-critical activities to try to recover.Lack of Motivation or Pleasure: When all your energy is sapped, even things you normally enjoy can feel like chores. A hobby you love feels too demanding. Meeting a friend for a fun activity feels daunting. This can be tricky because it can start to look like depression. In fact, chronic exhaustion and burnout can lead to depression, and they share some symptoms. One distinguishing factor some people notice: if it's primarily AuDHD fatigue, when you do occasionally get a burst of energy or hyperfocus (say something really interests you or you had a very restful period), your mood and motivation bounce back. Whereas with clinical depression, even on good energy days you might not feel joy. It can co-occur though, so it's always good to be mindful of mental health – but often what we think might be “I'm depressed or lazy” is actually “I'm burnt out and my brain is desperately trying to conserve energy.”Failure to Rejuvenate: The hallmark sign – you tried to rest, and it “didn't work.” Like you slept in, but you still feel tired. Or you spent the evening doing nothing, but feel no more ready to face the next day. It might feel like you have a permanently low battery that never gets past 50%, no matter what you do. This is a big clue that something about the type of rest or the amount of rest isn't matching what you need (we'll address that soon). It can also be a sign of deeper burnout, where short-term fixes won't cut it and you might need a more significant change or longer recovery time.Frequent Illness or Pain Flare-ups: I'll mention this too – when you're chronically exhausted, your immune system can weaken. You might catch every cold that comes around, or if you have conditions like migraines or fibromyalgia (common in neurodivergent populations), they might flare when you're overtaxed. It's like your body is waving the white flag through symptoms.Does some of that feel familiar? It's not a fun list, I know. But recognizing these signs in yourself is important. It's the first step to acknowledging, “I'm not lazy, I'm not failing at self-care – there's something very real going on that I can address differently.”Now, the big question: What can we do about it? How do we recharge all these different batteries properly, so that rest actually means something and we can start to restore our energy (and maybe even prevent getting so drained in the first place)? Let's move into the practical part: strategies and tips to manage your energy as an AuDHD person.Tips and Strategies for True RechargingAlright, now that we've dissected the problem, let's talk solutions. The goal here is to help you rest smarter, not just more. We want to target the right kind of rest for the exhaustion you have, and also manage our lives in a way that prevents draining every battery to zero if possible. Here are some strategies and tips, a blend of personal experience, science-backed advice, and things that many neurodivergent folks find helpful:1. Identify What Kind of “Tired” You Are: When you feel wiped out, take a moment to do a self check-in: What exactly feels drained? Is it your brain (mental fatigue, too many thoughts)? Is it emotional (feeling numb or overly sensitive)? Sensory (craving quiet/darkness or feeling jumpy at sounds)? Physical (body is heavy, sleepy)? Social (sick of people, need solitude)? There's no one right answer – it could be “all of the above,” but try to sense which ones are strongest. This matters because the remedy depends on the cause. If your tiredness is mostly physical, then physical rest (sleep, a nap, or just gentle activity) will help most. If it's mostly sensory, then you might need low stimulation (noise-cancelling headphones, a dark room, minimal touch). If it's mental, you might need to give your brain a break from consuming info – maybe do something hands-on or take a walk in nature without your phone. Practice asking yourself “What kind of tired am I right now?” and “What would truly feel nourishing?” It might take time to figure it out, but even just pausing and naming it can prevent you from automatically doing the wrong kind of rest.2. Embrace Different Types of Rest: Building on the above, familiarize yourself with the idea that rest is not just sleep or sitting around. There are many types of rest – some experts break it down into categories like: physical, mental, sensory, social, emotional, creative, spiritual. This might sound abstract, but it's actually practical. For instance:If you've been around people all day (social drain), you likely need social rest – some time alone or with people who are “easy” to be around (like a close loved one who you don't have to put on a show for).If your senses are overloaded (sensory drain), you need sensory rest – a break from input. That could mean a quiet dim room, or closing your eyes for a bit, or a soothing sensory experience like a warm bath (which calms the system).If you've been solving problems and on the computer nonstop (mental drain), your brain needs mental rest – do something low-demand like doodling, listening to gentle music, or literally daydreaming. Let your executive brain go offline for a bit.If you've been masking and managing emotions (emotional drain), you might need emotional rest – which could look like journaling your true feelings, having a good cry, talking to someone you trust and letting out all the bottled-up stuff, or just engaging in something that makes you belly-laugh or feel comforted. It also might mean giving yourself permission to not care for a little while about others' expectations.If you have an under-stimulation fatigue (sometimes ADHDers get exhausted from boring routines), you might need creative or novelty rest – which ironically means doing something interesting that fills your tank (like a fun hobby, a new game, something that sparks joy). This is why “rest” isn't always just doing nothing; sometimes our brains are tired from monotony and need a safe kind of excitement or creativity to feel revitalized.And of course, physical rest is important if your body is tired – that means sleep, nap, or gentle movement that helps you relax (like stretching, yoga, slow walking – often called “active rest” because it helps circulation and muscle recovery without being strenuous).Mix and match these as needed. Often, we need a combo. Say you had an overstimulating workday – you might need sensory + social rest (e.g. go to a dim room alone) and mental rest (don't force yourself to tackle a big project in the evening). Or if you spent all day caregiving your kids (social + emotional + sensory drain, parents I see you!), you might need physical rest (put your feet up) plus emotional rest (vent to a friend or watch a comfort show that lets you feel something). Being intentional about the type of rest means your downtime is more likely to actually recharge the depleted battery, not just scratch some other itch.3. Schedule Targeted Recharge Time (and Protect It): We often plan our work or social events, but we don't plan our recovery, and then it either doesn't happen or gets eaten up by other things. If you know certain activities drain you, start building in counter-balances. For example:If you have a big social event on Saturday, block Sunday morning as “quiet time” for yourself in a way that addresses the expected drain. If the party will be loud and socially demanding, maybe Sunday morning is reserved for a nature walk alone (sensory calm + solitude).If weekdays drain your executive function (as they do for many of us), maybe declare one evening a week as “no-decisions evening” – prepare a simple routine meal or order takeout, and do a low-brain-power activity. Treat it like a meeting with yourself that you don't cancel.Use tools like alarms or calendar reminders to check in with yourself during the day. Sometimes we literally forget to rest. A short pause mid-day to ask “How am I feeling? Need water? Need a break from noise?” can prevent deeper depletion. I personally have a sticky note on my monitor that says “Pause: Breathe & Feel – what do you need?” because otherwise hours go by and I haven't even unclenched my shoulders.Learn to anticipate crashes: If you notice a pattern like “Every day around 3 PM I crash,” consider adding a 15-minute rest break at 2:30 – maybe a quick walk or a stretch, or listening to a calming song with eyes closed. It's like a pit stop for your brain so it can finish the day.And importantly, protect that rest time. It's tempting to give it up when someone asks a favor or an extra task pops up. But remember, without that recharge, you won't be at your best and you might pay for it double later. Treat rest as an important appointment with yourself – because it is!4. Reduce Masking and Energy Leaks Where Possible: We can't always drop the mask – the world isn't always accommodating, and in some situations you might feel it's necessary to appear “on.” But consider where you can safely be more yourself or make things easier:Communicate needs to close friends or family: Let them know that after a certain time or event, you might be quiet or need to leave early due to exhaustion. Educating the people around you that “I get overstimulated or drained and it's just how my brain works” can build understanding and reduce the need to put on a show. If your friends know you're going to be sitting in the corner petting the cat after an hour at the party, and they're cool with it, you don't have to force yourself to mingle beyond your capacity.Stim and relax, even in small ways: If you've been holding in all your fidgeting or sensory self-soothing at work, take bathroom breaks or “fresh air breaks” where you can wiggle, shake out, do some deep pressure (like a quick self-hug or wall push-ups) – basically let your body reset. These mini-releases throughout the day can prevent the massive end-of-day collapse.Delegate or use supports for executive tasks: Energy leaks happen when we spend way too long on something because our brain is struggling. If you can afford it or have the option, use tools to reduce effort: maybe that's using a grocery delivery service instead of roaming overwhelming aisles, or using a scheduling app to remember appointments instead of trying to hold it all in memory. Perhaps at work you can ask for an accommodation like written instructions or a quieter workspace or flexible hours. Finding areas where you're expending extra effort just to keep up, and finding a smarter workaround, can save precious energy for where you really need it.Learn where you can say “no”: This is tough, but are there social interactions or obligations you can limit? You don't have to attend every gathering or help every person who asks, especially if you know it will overextend you. It's perfectly okay to have a quota – like one social event per weekend, or keeping weeknights free – whatever works for you. Saying no to others is saying yes to yourself, to your rest.5. Calming the Overactive Nervous System: Since stress and sensory overload keep us in high alert, actively practicing techniques to switch into “rest mode” can be a game changer. Some approaches:Breathing exercises: Even something as simple as 3 deep slow breaths can signal your body to relax. One technique is the 4-7-8 breath (inhale for 4, hold 7, exhale 8) which can reduce anxiety. Or try diaphragmatic breathing (belly breaths). Doing this periodically, and especially before bed, can help lower that cortisol and adrenaline.Progressive muscle relaxation: Tense and release muscle groups one by one. This not only relieves physical tension but also helps you notice where you've been holding stress (like “wow, my jaw was super tight!”).Sensory comfort: Use tools that help you feel safe and calm. For some, that might be a weighted blanket or a soft hoodie. For others, it's noise-cancelling headphones or listening to white noise/rain sounds. Dimming the lights in the evening, using warm-colored bulbs instead of harsh white light, can cue your brain that it's wind-down time. Basically, create a little sensory safe space for yourself when you need to recharge.Mindfulness or meditation: I know, not everyone's into meditation, but even a few minutes of sitting and noticing your surroundings or your breath can pull you out of the racing thoughts and ground you. Mindfulness can also help with interoception – if you practice checking in with bodily sensations in a non-judgy way, you might start catching those “I'm thirsty” or “I'm anxious” cues earlier. There are apps and guided meditations specifically geared towards relaxation and body awareness, which some neurodivergent folks find useful (and if traditional meditation is hard, things like mindful walking or even a repetitive hobby can be meditative).Therapeutic supports: If anxiety or an overactive stress response is a major issue, consider professional support. Therapy (like cognitive behavioral therapy or somatic therapies) can help you develop coping strategies and address triggers. For some, certain medications or supplements that regulate sleep and anxiety (like melatonin for sleep, or as prescribed by a doctor, maybe an SSRI for anxiety) can also be part of the puzzle. There's no shame in using every tool available to help your nervous system find balance.6. Tune Into and Honor Your Body's Signals (Practice Interoception): This one is about building the skill of listening to your body. It might sound odd if interoception is an issue, but you can improve it with practice. Some ideas:Set external reminders to check internal states. For example, keep a water bottle at your desk as a visual cue to drink regularly, rather than waiting to feel thirsty. Have scheduled snack times so you don't go 10 hours without eating. Use a bedtime alarm to remind yourself to start a wind-down routine, since you might not notice you're tired until 2 AM when you're dead tired.Use tracking or journals: Sometimes writing down energy levels or what you did and how you felt can reveal patterns. Maybe you notice “Every time I have back-to-back meetings, I get a migraine in the evening.” That's a clue to insert breaks or coping strategies around meetings. Or “Whenever I skip lunch, I get really anxious by 4 PM” – aha, low blood sugar and stress might be combining. Tracking apps for mood/energy, or a simple diary, can improve your mind-body awareness.Body scan exercises: These are mindfulness exercises where you mentally scan from head to toe, noticing any sensations (tightness, hunger, discomfort, calm). Doing a short body scan once a day can train your brain to check in with places you normally ignore. You might catch “Oh, my heart is racing, maybe I'm more stressed than I realized,” or “My eyes ache, I might need to close them for a bit.”Don't wait for crisis to refuel: If you start recognizing the earlier signs of being low on a certain “battery,” try to address it then, not when you're already in meltdown or shutdown zone. This might mean proactively resting. For example, if you notice “I'm getting pretty peopled out at this gathering,” excuse yourself for a short break before you hit the wall. If you notice you're getting headachey and cranky at work, maybe step outside or to a quiet restroom for 5 minutes, rather than soldiering on until you can't function. We often override our early signals out of obligation or because we're used to pushing through. Give yourself permission to pause before you crash – it can make a world of difference in recovery time and intensity.7. Replenish the Basics: It sounds almost too basic, but when you're worn down, foundational health stuff becomes crucial: nutrition, hydration, movement, and sleep.Nutrition: A brain that's out of fuel will feel tired and foggy. Try to eat regularly and include protein and complex carbs in meals to keep your blood sugar stable (wild sugar swings can mimic anxiety and fatigue). If you're too tired to cook on bad days, no shame in keeping easy snacks or shakes around. The point is to give your body some real fuel. Also, deficiencies in things like iron, vitamin D, B12, etc., can cause fatigue – might be worth getting a check-up if you suspect it. Many ADHDers forget to eat; many autistics have limited diets – so a multivitamin or specific supplements might help if diet isn't covering bases (ask a doc or dietitian).Hydration: Even mild dehydration can cause tiredness and headaches. Keep water or something with electrolytes handy. If plain water is hard, try flavored or fizzy water. We often forget to drink when hyperfocused or out of routine.Movement: This is tricky because when you're exhausted, exercise sounds impossible. But gentle movement can actually create energy in the long run. It improves mood, reduces stress chemicals, and helps you sleep better later. The key is gentle and enjoyable: a slow stretch while watching a show, a short walk in fresh air, dancing to one song in your room – something that gets your blood flowing without feeling like a chore. It's like giving your body a little tune-up. Some days you might only manage to move from bed to couch and that's okay too; when you have the energy, try sprinkling small movement snacks into your week.Sleep hygiene: Since many of us have irregular sleep, paying attention to sleep hygiene is huge. That includes things like having a consistent-ish bedtime and wake time, making your bedroom as comfortable and low-stimulation as possible, avoiding screens right before bed if you can (blue light and information overload trick the brain into staying awake), or using tools like white noise, eye masks, or even melatonin if appropriate. Also, if racing thoughts keep you up, try keeping a notepad by the bed – jot down anything on your mind to “offload” it, or listen to a calming audiobook or podcast at low volume to focus your mind away from anxious thoughts (just not one that's too stimulating). The goal is to help your brain and body wind down enough to get quality rest. If insomnia or delayed sleep phase (night-owl syndrome) is severe, consider talking to a doctor – there are interventions that can help (like light therapy, prescription meds, etc.). Don't just accept terrible sleep as your fate – it's something worth troubleshooting, because better sleep will amplify all your other efforts to recharge.8. Be Compassionate and Adjust Expectations: This might be the most important tip: be kind to yourself. Recognize that your fatigue is not a moral failing. You're not lazy for being tired. AuDHD individuals truly do face more daily stress and effort – of course you're exhausted! Start reframing rest as productive and necessary, not a luxury. It's part of your health and effectiveness. Also, communicate and adjust expectations with those around you (and with yourself). Maybe you can't do “all the things” in one day that others can – that's okay. Quality of life improves when you stop comparing your energy output to neurotypical standards.It's fine if you need two hours of downtime for every three hours of social time, or if after work your only goal is making a simple dinner and then chilling – that might be what allows you to thrive long-term. If you plan a restful vacation and you spend the first two days just sleeping and doing nothing – perhaps you needed that. Trust that meeting your needs is the path to unlocking your best self. When you do start feeling more recharged, you'll actually be able to do the things you want to do, and enjoy them, which is the ultimate goal.Each small step – whether it's learning to identify your tiredness type, or setting a boundary, or finding a perfect snack that keeps you from crashing – is a win. Celebrate those. We often have a perfectionist streak or we've been made to feel we're not doing enough. But here you are, learning how to take care of your remarkable, unique brain and body. That's absolutely something to be proud of.Reflection QuestionsAs we come to the end of this episode, I want to leave you with some reflection questions. These are meant to help you apply what we've discussed to your own life. You might consider journaling your answers, or just ponder them quietly. There are no right or wrong answers – they're just prompts for self-discovery and practical planning.1. Which aspects of your life drain your energy the most lately? Try to name them: Is it social interactions? Sensory environments? Work-related executive function tasks? Emotional stress? Recognizing your biggest drains is the first step to addressing them.2. When you do feel recharged or have a good energy day, what helped? Think of a recent time you actually felt rested or upbeat – what had you done (or not done) leading up to that? Identifying even small things that rejuvenate you (like “I felt great after that hike” or “having a quiet morning to myself made a difference”) can give clues to the kinds of rest you need more of.3. What type of rest do you think you're not getting enough of? (Physical, mental, sensory, social, emotional, creative, spiritual, or any category that resonates with you.) How did you realize this – what signs or feelings point to that deficit? For example, “I might need more sensory rest because I've been feeling jumpy and irritable by evening,” or “I suspect I need mental rest because my mind feels overloaded and I'm forgetting things.”4. How well are you noticing your own needs in the moment? Do you catch yourself getting tired, hungry, overstimulated early, or only when you're at a breaking point? Reflect on one or two cues you might have missed recently (like “I missed that I was thirsty and got a headache”). What could you do to catch those sooner next time (maybe a reminder or a mindful pause)?5. What is one barrier that often stops you from resting or recharging properly? Is it guilt (“I feel like I should be productive”)? Is it external (too many responsibilities, lack of a quiet space)? Maybe it's not knowing how to rest effectively. Write down that barrier. Now brainstorm one or two ways you could lessen that barrier. For instance, if guilt is a barrier, how can you remind yourself that rest is necessary (perhaps repeat a mantra: “Rest is refueling, not wasting time”)? If time is a barrier, what can you delegate or drop or reschedule to carve out a bit of downtime?6. What are some small recharge rituals you could build into your day or week? Think of tiny actions that give you even a spark of energy or calm. It could be a 5-minute tea break with no phone, or doing a silly dance when nobody's watching, or stepping outside to feel the sun for a moment. Make a little list of “go-to quick rechargers” for yourself. These will be handy when you notice a specific battery running low.7. Envision your ideal restored self. Imagine that you have been taking really good care of all these different energy needs for a while. How do you think you would feel and act? Paint a mental picture: “I wake up feeling __, I go through my day feeling __, I have energy for __, I feel more __.” Describe the differences you'd notice in a well-rested, balanced version of you. This vision can be motivating – it's not a fantasy, it's something that can gradually become reality as you experiment with what works for you. What part of that vision could you start working towards now?Take your time with these questions – you might even revisit them periodically, because your needs can change over time or in different seasons of life. The purpose is to increase your self-awareness and to spark ideas for adjustments that can lead to better energy management.ConclusionWe've covered a lot in this episode, so let's briefly recap: The simple “social battery” idea doesn't quite cut it for AuDHD brains because our energy drains on multiple fronts – masking, sensory overwhelm, executive function effort, chronic stress, and missing our internal signals. Just “resting” in a generic sense often isn't enough; we need the right kind of rest for the right kind of tired. The physiology of our brains and bodies explains why this exhaustion is real and not laziness. And the good news is, there are strategies to help – from mixing up the types of rest you get, to planning recovery time, to advocating for your needs and learning to read your body's signals better.I hope you found some validation in this – you're not alone in feeling this exhaustion, and you're not failing when rest doesn't magically fix it. It's a complex issue, but you can make progress by understanding your unique energy profile. Even small tweaks – like using earplugs in a noisy place or taking a 10-minute brain break – can yield noticeable benefits. Remember, you deserve to feel restored and it is possible with patience and practice.Thank you for joining me today on Authentically ADHD. I'm proud of you for taking this time to learn about how to better care for yourself. If this episode resonated with you, feel free to share it with friends or anyone who might be running on empty and not know why. And if you have your own tips or experiences with the “social battery” and AuDHD life, I'd love to hear them – you can reach out on my socials or leave a comment.Paid subscribers get the downloadable “AuDHD Social Battery Decoder Kit” — a printable, fillable workbook that turns today's episode into actual tools you can use when you're fried.If you've ever rested and still felt exhausted, it's not because you're doing rest “wrong.” It's because your brain wasn't depleted by “socializing” alone — it was depleted by masking, sensory load, executive function taxes, stress activation, and not noticing your needs until your system was running on fumes.This kit helps you:identify what actually drained youmatch the right kind of rest to the system that's depletedbuild simple recovery ritualsuse copy/paste scripts when your brain goes blankplan your week like an AuDHD nervous system deservesIt's practical. It's kind. And it's designed for brains that hate homework.Until next time, be kind to yourself, pay attention to those batteries, and remember: rest isn't a reward, it's a necessity. Stay authentic and we will talk soon!This Substack is reader-supported. To receive new posts and support my work, consider becoming a free or paid subscriber.Paid Bonus at end of this: Get full access to carmen_authenticallyadhd at carmenauthenticallyadhd.substack.com/subscribe

Join Dr. Daniel Simon as he explores the groundbreaking collaboration between Dr. Sanford Markowitz and Dr. Andrew Pieper. Discover how their combined expertise in cancer genetics and psychiatry is leading to innovative approaches that tackle Alzheimer's and traumatic brain injury, providing hope and insight to those affected by these devastating conditions.Learn more about Sanford Markowitz, MD, PhDLearn more about Andrew Pieper, MD, PhDNEW! View our Science@UH video podcast on YouTubeLearn more about the University Hospitals Research & Education Institute

An eight-million dollar grant program has supported industry to scale up production of the methane-inhibiting seaweed, Asparagopsis. Seaweed Farming program activities are expected to generate increasing economic returns over the next 30 years. Rural Reporter Brady Evans spoke with Fisheries and Aquaculture Assistant Secretary, George Day about how the money has been used and how it sets us up for the future.See omnystudio.com/listener for privacy information.

Today, we are honored to welcome back to the podcast one of the most respected and influential health experts in the world, Chervin Jafarieh, who has committed his life's work to seeking knowledge and truth. In 2018, Chervin founded Cymbiotika—an innovative wellness company that designs sophisticated, organic nutritional formulations scientifically proven to increase vitality and longevity by filling the nutritional gaps from a typical modern-day diet. In this episode, Krista + Chervin will open your eyes to the power that lies within you to regain sovereignty of your body and life. They talk about parasites from a health, societal and energetic perspective—how they can take over your consciousness and entire being. Jam packed with unconventional insights, this is one you won't want to miss. Morning Microdose is a podcast curated by Krista Williams and Lindsey Simcik, the hosts and founders of Almost 30, a global community, brand, and top rated podcast.With curated clips from the Almost 30 podcast, Morning Mircodose will set the tone for your day, so you can feel inspired through thought provoking conversations…all in digestible episodes that are less than 10 minutes.Wake up with Krista and Lindsey, both literally and spiritually, Monday-Friday.If you enjoyed this conversation, listen to the full episode on Spotify here and on Apple here.

Dan Schmitt, President and CEO of Actuate Therapeutics, is developing a cancer therapy that inhibits GSK3β, a key enzyme that is hijacked in cancer cells to drive tumor growth. Inhibiting this enzyme can impact the cancer cells and stimulate an immune response against the tumor. Actuate selected metastatic pancreatic cancer as their first target due to unmet need and promising data for their lead drug candidate. This could represent a significant advancement in the treatment of metastatic pancreatic cancer, offering a new standard-of-care option.   Dan explains, "So, GSK-3β is a known quantity across a number of inflammatory diseases. It was understood when we first started the company that, particularly in cancer cells, GSK is hijacked in its activity. Basically it's been shown that in normal cells, GSK-3β sits in the cytoplasmic domain and there it's involved in multiple paths, basically in glucose metabolism. But in cancer cells, it translocates into the nuclear compartment, and there it's accumulated at much higher levels and then sits upstream of a pro-oncogenic set of pathways, all mediated by NF-κB. NF-κB is notorious in cancer. It regulates gene expression involved in tumor growth and progression, chemoresistance, and protects tumor cells from death." "So it's been very difficult to target NF-κB directly, but we can target GSK-3β directly, specifically and potently, and therefore downregulate those key oncogenic processes. And that's really where we started the company, that set of activities of this protein. What's been shown since we've been in the clinic is that there is also a resulting upregulation of immune response from the host towards the cancer itself based on this inhibition of GSK-3β as well."  #ActuateTherapeutics #Cancer #PancreaticCancer #MetastaticPancreaticCancer  actuatetherapeutics.com Download the transcript here

Dan Schmitt, President and CEO of Actuate Therapeutics, is developing a cancer therapy that inhibits GSK3β, a key enzyme that is hijacked in cancer cells to drive tumor growth. Inhibiting this enzyme can impact the cancer cells and stimulate an immune response against the tumor. Actuate selected metastatic pancreatic cancer as their first target due to unmet need and promising data for their lead drug candidate. This could represent a significant advancement in the treatment of metastatic pancreatic cancer, offering a new standard-of-care option.   Dan explains, "So, GSK-3β is a known quantity across a number of inflammatory diseases. It was understood when we first started the company that, particularly in cancer cells, GSK is hijacked in its activity. Basically it's been shown that in normal cells, GSK-3β sits in the cytoplasmic domain and there it's involved in multiple paths, basically in glucose metabolism. But in cancer cells, it translocates into the nuclear compartment, and there it's accumulated at much higher levels and then sits upstream of a pro-oncogenic set of pathways, all mediated by NF-κB. NF-κB is notorious in cancer. It regulates gene expression involved in tumor growth and progression, chemoresistance, and protects tumor cells from death." "So it's been very difficult to target NF-κB directly, but we can target GSK-3β directly, specifically and potently, and therefore downregulate those key oncogenic processes. And that's really where we started the company, that set of activities of this protein. What's been shown since we've been in the clinic is that there is also a resulting upregulation of immune response from the host towards the cancer itself based on this inhibition of GSK-3β as well."  #ActuateTherapeutics #Cancer #PancreaticCancer #MetastaticPancreaticCancer  actuatetherapeutics.com Listen to the podcast here

Solifenacin is a bladder antimuscarinic medication most commonly used for overactive bladder (OAB) with symptoms of urinary frequency, urgency, and urge incontinence. Like other agents in its class, understanding the pharmacology can help anticipate potential side effects, drug interactions, and downstream prescribing problems. Mechanism of Action Solifenacin selectively blocks muscarinic M3 receptors in the bladder detrusor muscle. Inhibiting these receptors reduces involuntary bladder contractions, increases bladder capacity, and delays the urge to void. While M3 selectivity may theoretically reduce side effects compared to nonselective antimuscarinics, in clinical practice, many anticholinergic effects still occur. Adverse Effects Because muscarinic receptors are present throughout the body, solifenacin can lead to a range of anticholinergic adverse effects: Dry mouth – among the most common, can be significant enough to cause dental issues with long-term use. Constipation – especially problematic in older adults; severe cases may require hospitalization. Blurred vision – due to impaired accommodation. Cognitive impairment – increased risk in older adults, particularly with cumulative anticholinergic burden. Urinary retention – paradoxical worsening in patients with bladder outlet obstruction. Drug Interactions CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) can increase solifenacin plasma concentrations, raising the risk of side effects. Other anticholinergics (e.g., diphenhydramine, tricyclic antidepressants, other bladder antimuscarinics) can result in additive toxicity and higher anticholinergic burden. QT-prolonging drugs (e.g., amiodarone, certain fluoroquinolones) may have additive cardiac risk since solifenacin has been associated with QT prolongation in rare cases. Prescribing Cascade Examples Constipation → Laxative initiation – A patient starts solifenacin for OAB and develops severe constipation, leading to chronic use of stimulant laxatives like senna or bisacodyl. Dry mouth → Mouth rinse prescription – Dry mouth is treated with saliva substitutes or prescription rinses, instead of reassessing the anticholinergic therapy. Cognitive decline → Donepezil initiation – In older adults, cognitive impairment may be mistaken for dementia progression, leading to cholinesterase inhibitor prescribing—directly counteracting the anticholinergic effects of solifenacin. Solifenacin can be an effective treatment for OAB, but the risk of adverse effects and prescribing cascades—especially in older adults—cannot be ignored. Healthcare professionals should regularly review the indication, monitor for anticholinergic burden, and look for opportunities to deprescribe when appropriate.

Send us a textHow brain synapses work and fuel themselves with fat.Episode Summary: Dr. Timothy Ryan talks about the high energy costs of synapses, the role of mitochondria and glycolysis, and challenge the long-held view that the brain relies solely on glucose by discussing new evidence that neurons burn fats from lipid droplets for fuel, especially during activity. The talk touches on metabolic flexibility, links to epilepsy treatments like ketogenic diets, neurodegenerative diseases, and future research on brain energy sources.About the guest: Timothy Ryan, PhD is a professor of biochemistry at Cornell University. His research focuses on the molecular mechanisms of synaptic transmission, particularly vesicle recycling and the bioenergetics that power neural communication. Discussion Points:Synapses are tiny structures with ~100 vesicles per site (on average), converting electrical signals to chemical ones.Brain tissue is energy-hungry due to trillions of synapses (in humans), relying on local mitochondria (present in only ~half of synapses) and glycolysis.Vesicles use proton pumps and transporters to concentrate neurotransmitters, requiring ATP to maintain gradients.Neurons are metabolically fragile; cutting fuel supply quickly impairs synapses.Dogma held brains don't burn fats, but new work shows neurons form lipid droplets (fat stores) that are invisible because constantly used for energy via beta-oxidation.Silencing neurons builds lipid droplets like resting muscle; activity speeds their breakdown, indicating demand-driven fat use.Inhibiting neuron-specific fat-processing enzymes accumulates droplets and induces torpor (hibernation-like state) in animals, signaling metabolic stress.Ketogenic diets aid epilepsy by shifting to ketones; fats may explain this, with potential ties to aging and neurodegeneration like Alzheimer's.Brain may be a "hybrid" fuel user (glucose + fats), with open questions on fat sources and roles in cognition or disease protection.Related episode:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

BUFFALO, NY — April 29, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 20, 2025, titled “Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP).” Researchers, led by first author Sudipta Bar and corresponding authors Amit Sharma and Pankaj Kapahi from the Buck Institute for Research on Aging, have found that the enzyme ADAM19 plays an important role in regulating aging in cells and inflammation in the gut. Their study shows that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells. This discovery points to a new possible way to treat gut disorders related to aging by reducing the harmful signals from senescent (aging) cells. As individuals age, DNA damage can lead to the accumulation of senescent cells, contributing to tissue damage. These are cells that stop dividing and release harmful inflammatory substances called the senescence-associated secretory phenotype (SASP). In this study, researchers used fruit flies to search for genes involved in radiation-related gut damage. They identified a gene called meltrin, which is similar to human ADAM19. When meltrin was turned off, the flies had less gut leakage, less inflammation, and fewer signs of cellular aging. “Through an unbiased genome-wide association study (GWAS) utilizing 156 strains from the Drosophila Genetic Reference Panel (DGRP), we identified meltrin (the drosophila orthologue of mammalian ADAM19) as a potential modulator of the senescence-associated secretory phenotype (SASP).” To test if these results applied beyond flies, the team inhibited ADAM19 in mice using a drug called batimastat. Mice treated with the drug after chemotherapy exposure had stronger gut barriers and lower levels of inflammatory markers. The findings extended to human cell cultures, where ADAM19 inhibition reduced signs of cellular aging, including the expression of SASP proteins and β-galactosidase, a classic aging marker. Importantly, this approach does not kill aging cells like many 'senolytic' therapies but instead reduces the harmful substances they release, making it a potential "senomorphic" strategy. The study also showed that ADAM19 helps release certain SASP proteins by cutting them at the cell surface, suggesting a direct role in regulating inflammatory signals. Through proteomic analysis, the team identified 12 SASP proteins that were significantly reduced when ADAM19 was blocked. Many of these proteins are linked to inflammation, immune response, and tissue remodeling in diseases such as inflammatory bowel disease and Crohn's disease. This connection underlines the relevance of the findings for treating chronic gut disorders in aging populations. By targeting ADAM19, researchers may have found a new way to protect gut health and lower inflammation caused by aging cells. This study offers a promising path for creating treatments that maintain healthy tissues without having to destroy aging cells, which could benefit people with gut damage related to aging or medical treatments. DOI - https://doi.org/10.18632/aging.206224 Corresponding authors - Amit Sharma - amit.sharma@sens.org, and Pankaj Kapahi - pkapahi@buckinstitute.org Video short - https://www.youtube.com/watch?v=dRfxQ20O2fQ Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

The Surpassing Glory of God's Promises in Christ 2 Corinthians 3:7-18 Our sermon text is from 2 Corinthians 3 verses 7-18. We learned in the beginning of chapter 3 that the apostle Paul was a minister of a New Covenant. That new covenant is received through the Spirit and resulted in life. That is contrasted with the letter of the law, which, as Paul put it, kills. The rest of chapter 3 unpacks the old and new covenants. As I read, listen for the similarities and differences between the two. Reading of 2 Corinthians 3:7-18 Prayer I don't know if you have been following it, but later this week, 7 planets will be visible in the night sky at the same time. That is a rare event. In fact, it's been quite the season of interesting astrological occurrences. Maybe you experienced the partial solar eclipse last year. Or 5 years ago, you saw the great conjunction. That was when Jupiter and Saturn overlapped in the sky. Apparently, that only happens once every 400 years. And coming up in just 3 weeks, there will be a total lunar eclipse. You are probably wondering, how does this relate to 2 Corinthians 3? Well, 2 Corinthians 3 is considered by some to be the most difficult chapter to understand in all of Paul's letters. That's debatable, of course, but it certainly contains some lofty concepts. At this chapter's core is the theological intersection between the Old and New Testaments. That's significant. And obviously important. And that brings us to the moon and sun and planets. You see, the central point is that the glory of the old covenant was a fading reflection of the glory of the new to come. The new covenant has come and it has eclipsed the glory of the old. It's like the way the moon and planets reflect the light of the sun at night. But when the sun rises, its light is so bright that it completely outshines the moon and planets. The old covenant reflected the new before the new came, but the new has come, and the old has now passed away. By the way, this is one of two main passages of Scripture that compare the old covenant with the new. Hebrews chapter 8-10 is the other. We read part of chapter 10 earlier. The difference between Hebrews 8-10 and 2 Corinthians 3 is that Hebrews works through how God accomplished his promises in the new covenant. He's done that through Jesus perfect sacrifice for sin. In 2 Corinthians 3, we learn about the permanent nature of the new covenant and that we receive its benefits through the Spirit. So both teach about the old and new covenant but with different emphases. Earlier this week I spent some time analyzing how 2 Corinthians 3 compares the old and the new. I put a little chart together as I went. You can see that on page 4 of the bulletin. Really, it was for my benefit as I tried to get my mind around the contrast. But I included it in case it may be helpful to you. You can see that Paul's primary purpose here is a comparison of the two. ·       He gives us the nature of the covenants. The old carved on stone and the new written by the Spirit on our hearts. ·       He speaks of the fading glory of the one and the eternal glory of the other. ·       The old primarily focused on Israel, but the new expands that to God's people from all nations. ·       Even more, those who live by the old live with a veil over their hearts. But for those who have been freed by Christ, that veil is lifted and they are being transformed. ·       But the most weighty of all the comparisons is the eternal outcome. Those who put their trust in the old and reject the new are condemned. But those whose hearts have been transformed by the Spirit and who trust in Christ receive righteousness and life through the Spirit. It's really amazing how much is here in just a couple of paragraphs. Alright. We are going to focus in, first, on understanding the comparison, verses 7-11. And then we'll look at implications of that, today, in verses 12-18. You can see a few summary bullets there. Now, you may be wondering, why does it take such work to unlock the differences between the two? That is a great question. I wondered the same. Because it does seem that Paul jumps around and repeats himself. Why didn't he just spell it out in a clear linear way? The answer is, to his readers, he did. Paul spelled it out in a way they would understand. He used a Greco-Roman rhetorical argument called “a fortiori.” Lesser to greater. That will be on the test after the service. Just kidding. I had no idea that such a thing existed before this week. The argument goes that if something lesser is true, how much more sure and true is the thing that is greater. Its purpose is to elevate the greater reality. To do that there's a comparison and an elevation. And another comparison and another elevation. And then a further elaboration on a comparison and a further elevation. We can see that in these verses. One thing that clearly comes out is the amazing, surpassing, never ending glory of the new covenant. Look at verse 10 for example. “For if what was being brought to an end came with glory, much more will what is permanent have glory.” You see, these verses are not just a technical explanation. Rather, Paul was elevating the hearts of the Corinthians. He wanted them not only to know that the new is greater and eclipses the old, but he wanted their hearts to see and rejoice in what God has done. How he has fulfilled all the promises of the old in the new. Going back to the moon and sun… you know, when it comes to light and energy, there's no comparison. The moon can only reflect the light of the sun. Yes, in the middle of the night, when a full moon is out it really lights up the surroundings. You can even see shadows. You can see where you are going. If you wanted to, you could even turn off your car's headlights. Don't do that, though… but you would be able to see. But where does that light from the moon and planets come from? It comes from the sun. The light of the sun reflects off of them. The old covenant reflected the glory of the new which, in the Old Testament times, had yet to come. But also, let me ask, what is the lunar surface of the old covenant? Meaning what is the light from the new reflecting off of? Well, it reflects off of (1) the moral law, you know, the letters carved on stone – the 10 commandments, and it reflects off of (2) other laws that God gave through Moses like the ceremonial laws including sacrifices… and also (3) festivals and (4) the temple itself. All of it, in different ways, reflected the glory of what was to come in the new covenant. And they all tie together the Old Testament with the New Testament in profound ways. Ways that help us better understand the new. In the past, I've shared a little of my journey to seeing the Bible as one unified book. I remember when I was, I think, 22 years old. I could not wrap my mind around the purpose of God's law nor even the purpose of the Old Testament. It was a burning question in my mind. I couldn't let those questions go. Well, my Bible had cross references in the margins. And so, I set out to read through the New Testament and cross reference every single Old Testament cross reference. I worked on it a little bit every day. It took me about 3-4 months. It blew my mind. By the way, I still have that Bible in my office with a bunch of underlines and notes. Light bulbs kept going off as I saw more and more connections between God promises and laws in the Old and their fulfillment in Christ in the new. Before then, I used to think that the Old Testament had so many strange practices and peculiar events that had no relevance. But then their beauty came alive to me. I realized how in different ways they revealed God in his glory, they revealed his plan for redemption, and they revealed the need for atonement and the Messiah. All of those old covenant things were driving at what was to come. You see, for God's people in the Old Testament, the whole purpose of the different laws and ceremonies was to direct their attention to the promise of what was to come. Let me say something that is really really important. It was never about offering the sacrifices and obeying the law as a means for salvation. Never. Rather it was so that they could trust in God for what he would do. Their salvation was received by faith in Christ who was to come just as ours is received by faith in Christ who has come. This is illustrated for us in what happened at Mount Sinai. These verses in 2 Corinthians 3, refer to Moses veiling his face. You see, when the Israelites were freed from their slavery in Egypt, God brought them across the Red Sea and he brought them to the base of Mount Sinai. And God then called Moses to ascend the mountain to receive the law. And so Moses went. But in the meantime, the people began worshipping a golden calf instead of the one true God. And God's anger burned against the people. But… Moses pleaded with the Lord for mercy. And God relented. Moses was a mediator between God and his people. After that, God commanded Moses to go up the mountain again. Actually, he needed a new copy of the law because he had thrown down the first. But also, this time, God revealed his glory to Moses. Moses was only given a glimpse of God in his glory, but it caused Moses face to shine with the glory of God. When Moses descended, the people were afraid because of the reflected glory. And so Moses would veil his face to protect the people. Look at 2 Corinthians 3 verse 7. It says, “the Israelites could not gaze at Moses' face because of its glory.” Even the reflected glory was unbearable because of their sin. Again, Moses acted as a mediator of God's mercy by veiling his face. We learn a couple things from that. We learn there is glory in the law. As I mentioned last week, God's moral law is good and right and perfect. It reveals God's nature and his goodness. But it is only a reflected glory. We also learn that God's law requires a mediator, just as Moses mediated for the people. So, the law both directs us to God and it directs us to our need for Christ because of our failure to meet its standard. That explains verse 9. Look at it. “For if there was glory in the ministry of condemnation, the ministry of righteousness must far exceed it in glory.” The law is glorious but without a mediator, it brings condemnation. But the mediator of the new covenant has come. Christ has come. And he's accomplished and has fulfilled all that the law required. We are no longer condemned by the law. Through Jesus' righteousness, we are given life. That phrase in verse 9, “ministry of righteousness” is referring to the righteousness we have in Christ. You see, the sunrise has come. The sun is up. Yes, in the daytime we can faintly see the moon and we can occasionally see a planet. But the moon and plants no longer light anything up. Because the day has come. There's no more need for the reflected glory of the old because of the surpassing and permanent glory of the new covenant. Alright, let's now turn our attention to the implications for us -  verses 12-18. There are two implications - one negative and one positive. The first is when you only see the old and you reject the new. Look at verse 14. Paul, talking about unbelieving Israel, says, “For to this day, when they read the old covenant, that same veil remains unlifted, because only through Christ is it taken away. Yes, to this day whenever Moses is read a veil lies over their hearts.” Now, I don't think that there are any Jewish people here today who reject Christ. But that is who Paul is speaking about. They read the Old Testament. Some may think that by obeying the laws and celebrating the festivals that they are therefore justified in God's sight. They may even believe in a coming Messiah. But their hearts and minds are hardened and veiled. It would be like believing that the moon is shining with its own source of energy and light. And maybe even believing that sun does not exist. It would be like covering your eyes during the day so that you don't see the sun. Or sleeping when the sun is up and only being awake at night. They do not believe the new. They are trusting in the old for salvation. And because of that unbelief, to use Paul's earlier words, they will receive “the ministry of condemnation.” Let me expand this a little. I think there are some parallels here to the Roman Catholic church. In our church history Sunday school class this morning, we talked a little bit about the counter reformation. That was the church in Rome's response to the Protestant Reformation. And while yes, much of the immorality in the church was addressed, yet, the church doubled-down on many of its beliefs. Now, I know there are some faithful believers in the Catholic church, but over the centuries, the church has added unbiblical layers that veil Christ. Like the veneration of Mary, or like praying to the saints, or believing in an intermediate state to work off your sins, or going to a priest for intercession. Those are all merit-based or works-based righteousness things. They are in essence veiling the glory of God in Christ. It's kind of like a partial solar eclipse. The fulness of the glory of God in Christ cannot be fully seen. And because of it, many in the Catholic church, trust in these things and not the ministry of God in Christ. There are other parallel as well… like any rejection of the new covenant in Christ. That would include the “I'm a good person” theology. The belief that God will evaluate our good works and because of them consider us good in his sight. That is just a version of the old covenant which cannot save. It denies the sin and idolatry of our hearts and rejects the new covenant. Let me ask, how should we respond? How should we, who believe in the new covenant, respond to those groups? Well, we should seek to be ministers of the New Covenant, like Paul. What does that mean? That means praying for the work of the Holy Spirit to remove the veil over their hearts. It means revealing the failure of the old or the law to redeem. It means doing what Paul does here. Showing the glory of God in the ministry of the new covenant! Its exalting the person and work of Christ through his Spirit! It's showing what unveiled worship is as we behold God. Remember, it's not peddling God's Word, but rather it's exalting God for the exceeding glory of the new. Ok, there's another implication here. A positive one. And it relates to my favorite verse in this chapter. Look at verse 18. “And we all, with unveiled face, beholding the glory of the Lord, are being transformed into the same image from one degree of glory to another. For this comes from the Lord who is the Spirit.” I love that verse. Paul is speaking about those transformed by the ministry of the new covenant. Those whose hearts are not hardened nor veiled but who, through Christ, can behold the glory of God without condemnation! Those who have the ministry of his righteousness because our hearts have been transformed by his Spirit. And when we behold the wonder and glory of God in what he has accomplished, he does something in us. Or rather he is doing something in us. He is transforming us. He is conforming us to the image of Christ. More and more we will reflect his glory… in our countenance, in our thoughts, in our words, in our actions – in our hearts. Now, we can certainly inhibit that transformation. Our sin can block the light of the sun. As you know, this last week has been a little cold. But if you were outside during the day when it was sunny, you really got warmed by the sun. Inhibiting that transformation is like blocking the sun in some way. We do that when the comforts of this world become idolatrous. Or when our lust or anger or some other sin goes unchecked and unrepented of. Or when we forget to pray or engage in God's Word. All those things cause us to become cold.  They all inhibit the light of the sun reaching us… by our own doing. They all inhibits the transformation of God within us. But, as verse 18, says, when we behold God with unveiled face. When we come to him laying our sin before him, letting his Word wash over us. When glorying in the ministry of the new covenant becomes our life and righteousness, then God will be transforming us! He'll be transforming us from one degree of glory to another. These verses are not saying that we will become perfectly glorified. That will only happen when we pass from this life to the next. But more and more we will reflect the glory of God in Christ. And we will radiate that glory like the face of Moses. By the way, did you notice that the Lord is equated with the Spirit… multiple times, here. That word Lord, used here, is in reference to Jesus. What Paul is doing here is he is affirming God's oneness in the Trinity. It's not overlapping the roles of the Son and the Holy Spirit. The Holy Spirit applies the work of Christ in us. In fact, multiple times in the New Testament he is called the Spirit of Jesus. Christ works in us through his Spirit, to transform us from one degree of glory to another. It is his work. And that ties back to the new covenant. The ministry of the new covenant is the ministry of the Holy Spirit in us, not the ministry of the law. So, God has fulfilled all the promises of the old in the new. The glory of the old has faded away, and the surpassing glory of the new has come in Christ. The moon has set and the sun has risen. So may we all with unveiled hearts, behold the glory of God through the Spirit of the Lord Jesus. Amen.

Dave Lee discusses the contentious topic of estrogen in men's TRT. He highlights the polarized views surrounding estrogen testing and aromatase inhibition, emphasizing the confusion it creates for patients and leads many men to chase an unrealistic “Goldilocks zone” of estrogen inhibition. Key Takeaways: Blocking estrogen is unnecessary and harmful. Many of the benefits of testosterone come from its natural conversion into estrogen and DHT. Inhibiting this process can lead to negative side effects. The real problem isn't estrogen—it's inflammation and poor metabolic health. If men experience “estrogenic side effects,” it's usually due to improper dosing or metabolic dysfunction, not an inherent issue with estrogen itself. Testosterone dosing should prioritize stability. Weekly or biweekly injections create hormone fluctuations that cause side effects. Dave advocates for more frequent injections (at least three times per week) or using trans-scrotal testosterone cream, which provides a more stable and effective delivery method. Excess body fat contributes to unwanted estrogenic effects. Men with higher body fat percentages will naturally convert more testosterone into estrogen. The solution isn't blocking estrogen but losing fat through proper nutrition and exercise while optimizing TRT dosing. Victory Men's Health provides comprehensive hormone care. Clinics like Victory look beyond testosterone alone, addressing thyroid health, DHEA, pregnenolone, and insulin sensitivity for a more holistic approach to hormone optimization. Dave emphasizes that TRT should be customized based on an individual's health, lifestyle, and response to treatment. If you're struggling with side effects, the answer isn't to suppress estrogen but to refine your protocol and address underlying health factors. Dave Lee Instagram Click Here Victory Men's Health Click HereVictory Men's Health YouTubeFor questions email podcast@amystuttle.com Disclaimer: The Women Want Strong Men Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

Feeling like you're doing all the things but still not seeing results? Whether it's reaching that next income bracket, attracting more clients, or finally feeling in demand, this episode is for you.I break down the three major reasons why your business may not be growing and how to overcome them. You'll learn how misalignment, fear of visibility, and deep-rooted money beliefs could be capping your success and what to do instead.We chat all things:A subtle yet powerful misalignment that could be stalling your business growth and how to uncover it.An unseen force that's keeping you in the shadows, unknowingly capping your success.The invisible threads between your money story and the reality you're creating without even realizing it.A transformative shift that will help you release what's quietly holding you back so you can step into your fullest potential.The unexpected key to expansion; why doing less might be the breakthrough you've been searching for.If you're ready to shatter your income ceilings and step into your next level of business growth, this episode is a must-listen!Loved this episode? Don't forget to subscribe and leave a 5-star review so we can continue supporting powerhouse women like you on their journey to financial freedom.MMH LINKS: RICH & RESILIENT MONEY MOVES **ENROLLING NOW!** MONEY ARCHETYPE INTENSIVE FREE Take the Money Quiz Download the Money Mindset Track CONNECT Instagram @moneymindsethub YouTube @moneymindsethub Website www.moneymindsethub.com FAVS Podcast Host - They do the hard work for you - Try Buzzsprout Video/Podcast Editing - This AI tool makes editing a breeze - Try Descript Email Marketing - 50% off your first year with Flodesk - Sign up Legal Stuff - My fav legal team to protect your biz ...

How will inhibiting supportive housing impact the DTES? Guest: Guy Felicella, Harm Reduction and Recovery Advocate Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapamycin appears to be a universal anti-aging drug, extending the lifespan of all animals tested to date; it's the only known drug to do so.

David Happel is President and CEO of Sagimet Biosciences, a company developing drugs to treat metabolic diseases by targeting the underlying cause of fat accumulation in the liver. The drug denifanstat limits the activity of fatty acid synthase (FASN), an enzyme that regulates fat accumulation. This approach is a fat inhibitor, not a fat burner, the focus of other MASH drugs.  David explains, "Sagimet was founded back in 2007 as a private company with a group of medicinal chemists that had a particular target in mind, and this particular target was called fatty acid synthase, or FASN. FASN is a rather ubiquitous enzyme throughout the body that functions as a regulating enzyme in many organs. When FASN becomes overactive or overexpressed, it sort of throws things out of balance and, in particular, certain cardiometabolic diseases, such as MASH and in the liver. So, this group of chemists, in order to resolve this overactivity, developed a portfolio of FASN inhibitors, led by our lead program denifanstat, that seek to target the underlying cause of MASH and, therefore, really work to limit the activity of FASN, try to normalize it essentially is what we do." "For us and this particular molecule, it offers a differentiated approach to treating the disease for us and this particular molecule. Our molecule, denifanstat, is the only FASN inhibitor. It's the only fat inhibitor in development for MASH, making it rather unique. All the rest of the molecules or fat burners, fat oxidizers, and fat mobilizers include GLPs, FGF, and THR-beta. They all function by trying to burn fat peripherally and in the liver to a degree. They rely on that fat-burning mechanism to translate into reductions, inflammation, and fibrosis, which is important to treating MASH, but they've had varying degrees of success. Our molecule targets each pathway independently: fat, inflammation, and fibrosis, and has had a rather pronounced treatment effect as a result."  #SagimetBiosciences #MASH #FattyLiverDisease #FASN #FASNInhibitor #Fibrosis #Obesity #NASH #GLP1Agonists sagimet.com Download the transcript here

David Happel is President and CEO of Sagimet Biosciences, a company developing drugs to treat metabolic diseases by targeting the underlying cause of fat accumulation in the liver. The drug denifanstat limits the activity of fatty acid synthase (FASN), an enzyme that regulates fat accumulation. This approach is a fat inhibitor, not a fat burner, the focus of other MASH drugs.  David explains, "Sagimet was founded back in 2007 as a private company with a group of medicinal chemists that had a particular target in mind, and this particular target was called fatty acid synthase, or FASN. FASN is a rather ubiquitous enzyme throughout the body that functions as a regulating enzyme in many organs. When FASN becomes overactive or overexpressed, it sort of throws things out of balance and, in particular, certain cardiometabolic diseases, such as MASH and in the liver. So, this group of chemists, in order to resolve this overactivity, developed a portfolio of FASN inhibitors, led by our lead program denifanstat, that seek to target the underlying cause of MASH and, therefore, really work to limit the activity of FASN, try to normalize it essentially is what we do." "For us and this particular molecule, it offers a differentiated approach to treating the disease for us and this particular molecule. Our molecule, denifanstat, is the only FASN inhibitor. It's the only fat inhibitor in development for MASH, making it rather unique. All the rest of the molecules or fat burners, fat oxidizers, and fat mobilizers include GLPs, FGF, and THR-beta. They all function by trying to burn fat peripherally and in the liver to a degree. They rely on that fat-burning mechanism to translate into reductions, inflammation, and fibrosis, which is important to treating MASH, but they've had varying degrees of success. Our molecule targets each pathway independently: fat, inflammation, and fibrosis, and has had a rather pronounced treatment effect as a result."  #SagimetBiosciences #MASH #FattyLiverDisease #FASN #FASNInhibitor #Fibrosis #Obesity #NASH #GLP1Agonists sagimet.com Listen to the podcast here

Free book is here at https://www.memorizingpharm.com/books Summary Chapter 3.19 Antitubercular Chapter 3.19 discusses antitubercular medications used to treat tuberculosis (TB), which primarily affects the lungs. These drugs work by inhibiting mycobacterial growth or disrupting RNA synthesis, requiring long-term treatment (6 months to 2 years). Key considerations include monitoring liver function, avoiding alcohol, and ensuring patient adherence to therapy. Common medications include isoniazid and rifampin. Multiple Choice Questions How do antitubercular medications primarily work? a) Inhibiting protein synthesis b) Inhibiting mycobacterial growth c) Enhancing DNA replication d) Blocking cell wall formation How long does antitubercular therapy usually last? a) 1 month b) 3 months c) 6 months to 2 years d) 1 week Which organ's function should be closely monitored during antitubercular therapy? a) Heart b) Liver c) Kidney d) Lungs Which substance should patients avoid during antitubercular treatment? a) Caffeine b) Alcohol c) Dairy d) Citrus fruits What is a commonly used antitubercular medication? a) Penicillin b) Isoniazid c) Acyclovir d) Metronidazole Answer Key b) Inhibiting mycobacterial growth c) 6 months to 2 years b) Liver b) Alcohol b) Isoniazid

Send us a textIn this Ones Ready Podcast episode, Aaron and Peaches sit down with Dr. Tim Vermillion to explore essential topics on mental health, stress management, and support for military veterans. Dr. Vermillion shares his personal journey from the military to becoming a therapist, offering valuable insights into the impact of stress on the body and mind. They delve into the importance of breath work, physical activity, and the early signs of unhealthy coping mechanisms. Dr. Vermillion explains therapeutic approaches like cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR) for treating PTSD.The conversation also touches on groundbreaking treatments, including psychedelic therapies, hyperbaric therapy, and transmagnetic stimulation, with a focus on the VA's ongoing research. Dr. Vermillion emphasizes the critical role of active listening, non-confrontational support, and the military's efforts to destigmatize mental health struggles. He encourages veterans to seek help and be open about their challenges, offering hope through new and evolving therapies.Chapters00:00 Introduction and Background09:45 Understanding Stress and Its Management18:29 The Role of Breath Work and Physical Activity22:18 Recognizing Early Warning Signs of Unhealthy Coping26:23 Treating PTSD with CBT and EMDR32:23 Expanding Stress Tolerance34:18 Supporting Others in Managing Stress and Trauma34:31 Supporting Veterans' Mental Health36:05 Active Listening and Non-Confrontational Approaches37:02 Avoiding Directive Language38:09 Substances and Inhibiting the Healing Process40:29 Self-Medication and Negative Effects41:35 Comparing Substances: Alcohol, Tobacco, and Marijuana48:07 Destigmatizing Mental Health in the Military51:47 Following Mentors and Gaining Tacit KnowledgeSupport the showJoin this channel to get access to perks:https://www.youtube.com/channel/UC9aFBBZoBcQk8UUN_pO7nDA/joinBuzzsprout Subscription page: https://www.buzzsprout.com/680894/subscribeCollabs:Ones Ready - OnesReady.com 18A Fitness - Promo Code: 1ReadyATACLete - Follow the URL (no promo code): ATACLeteCardoMax - Promo Code: ONESREADYHoist - Promo Code: ONESREADYThe content provided is for informational purposes only and does not constitute legal advice. The host, guests, and affiliated entities do not guarantee the accuracy or completeness of the information provided. The use of this podcast does not create an attorney-client relationship, and the podcast is not liable for any damages resulting from its use. Any mention of products or individuals does not constitute an endorsement. All content is protected by intellectual property laws....

Free book is here at https://www.memorizingpharm.com/books Summary Tetracyclines 3.13  Tetracyclines are broad-spectrum antibiotics that inhibit bacterial protein synthesis. They're effective against gram-positive and gram-negative bacteria but have limitations due to side effects like photosensitivity, teeth discoloration, and risks in pregnancy/children under 8. Patients should avoid direct sunlight, dairy, and use alternative birth control. Multiple Choice Questions Tetracyclines work by: a) Inhibiting DNA synthesis b) Inhibiting protein synthesis c) Blocking cell wall synthesis d) Disrupting RNA transcription A side effect of tetracyclines is: a) Weight gain b) Teeth discoloration c) Hair loss d) Increased energy Tetracyclines are contraindicated for: a) Elderly patients b) Children under 8 c) Diabetics d) Patients with asthma Tetracyclines should not be taken with: a) Water b) Dairy products c) Meat d) Vegetables Patients on tetracyclines should: a) Avoid sunlight b) Increase sugar intake c) Exercise more d) Consume more salt Answer Key b) Inhibiting protein synthesis b) Teeth discoloration b) Children under 8 b) Dairy products a) Avoid sunlight

This episode is a replay of an interview I did circa 2017 with patent attorney Stephan Kinsella.Kinsella is the author of "Against Intellectual Property," and in our time together, he argues that IP laws, particularly patents and copyrights, are incompatible with traditional property rights and hinder innovation and progress. The conversation explores the origins of these laws, their impact on musicians and other creatives, and practical advice for navigating the current system while protecting artistic integrity. The discussion also delves into Austrian economics and how it provides a framework for understanding the issues with IP laws. Kinsella foresees a future where the increasing ease of circumventing these laws will pressure the industry to adapt to more free-market principles.Episode highlights:00:24 Stefan Kinsella on Intellectual Property02:43 Understanding Property Rights06:45 Austrian Economics and Intellectual Property20:08 The History and Problems of Copyright26:59 Practical Advice for Musicians42:13 Future of Intellectual Property44:23 Conclusion and Final ThoughtsResources mentioned:Against Intellectual Property by Stephan KinsellaStephan's websiteAbout the guest:Stephan Kinsella is an attorney and libertarian writer in Houston. He was previously General Counsel for Applied Optoelectronics, Inc., a partner with Duane Morris, and adjunct professor at South Texas College of Law Houston. A registered patent attorney, he received an LL.M. (international business law) from King's College London, a JD from the Paul M. Hebert Law Center at Louisiana State University (LSU), and BSEE and MSEE degrees from LSU.He has spoken, lectured and published widely on both legal topics, including intellectual property law and international law, and also on various areas of libertarian legal theory. You've been listening to Ba Vojdaan!, with James D. Newcomb. For more information about James, and to subscribe to the podcast, visit https://jamesdnewcomb.com. There you'll find a trove of materials available for immediate download. And be sure to follow James' travels and adventures on social media. All the info can be found at https://jamesdnewcomb.com. Thank you for listening!

Free book is here at https://www.memorizingpharm.com/books Summary Chapter 3.12 Aminoglycosides Chapter 3.12 covers aminoglycosides, a potent broad-spectrum antibiotic class that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Commonly used for severe infections like streptococcal endocarditis, they are administered intravenously or intramuscularly. Major concerns include nephrotoxicity, ototoxicity, and neurotoxicity, requiring close monitoring of renal function, hearing, and nerve damage. Multiple Choice Questions How do aminoglycosides work? a) Disrupting cell walls b) Inhibiting protein synthesis c) Blocking RNA transcription d) Preventing DNA replication Which condition can be treated with aminoglycosides? a) Hypertension b) Streptococcal endocarditis c) Diabetes d) Migraine Which side effect should be closely monitored? a) Hypertension b) Ototoxicity c) Hair loss d) Weight gain How are aminoglycosides usually administered? a) Orally b) Topically c) Intravenously or intramuscularly d) Subcutaneously Patients should be advised to: a) Avoid sunlight b) Monitor for tinnitus c) Take with antacids d) Increase salt intake Answer Key b) Inhibiting protein synthesis b) Streptococcal endocarditis b) Ototoxicity c) Intravenously or intramuscularly b) Monitor for tinnitus

Free book is here at https://www.memorizingpharm.com/books Summary 3.10 Fluoroquinolones Chapter 3.10 discusses fluoroquinolones, a synthetic class of broad-spectrum antibacterial medications that inhibit bacterial DNA replication. Used to treat pneumonia, skin, and urinary tract infections, they are effective against gram-positive and gram-negative bacteria. Caution is needed due to the risk of serious side effects such as tendon rupture, neuropathy, and photosensitivity. Patients should avoid antacids and direct sunlight while taking this medication. Multiple Choice Questions Fluoroquinolones work by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking DNA replication d) Inhibiting RNA synthesis Which of the following is a serious side effect of fluoroquinolones? a) Weight gain b) Tendon rupture c) Increased appetite d) Hair loss Fluoroquinolones should be taken: a) With milk b) With antacids c) Two hours before or after meals d) With calcium supplements Fluoroquinolones are contraindicated in children except for: a) Ear infections b) Common cold c) Complicated UTIs d) Allergies Patients on fluoroquinolones should avoid: a) Sun exposure b) Drinking water c) Vegetables d) Carbohydrates Answer Key c) Blocking DNA replication b) Tendon rupture c) Two hours before or after meals c) Complicated UTIs a) Sun exposure  

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary and Quiz 3.9 Sulfonamides  Chapter 3.9 discusses sulfonamides, a class of broad-spectrum antibiotics. They inhibit bacterial growth by interfering with metabolic processes and treat conditions like UTIs and bronchitis. Side effects include hypersensitivity, crystalluria, and increased photosensitivity. Patients should be advised to stay hydrated, avoid direct sunlight, and complete their prescribed doses. Multiple Choice Questions Sulfonamides work by: a) Inhibiting protein synthesis b) Blocking folic acid synthesis c) Preventing DNA replication d) Disrupting cell wall synthesis Which condition are sulfonamides commonly used to treat? a) High blood pressure b) Urinary tract infections c) Diabetes d) Migraine headaches Patients taking sulfonamides should: a) Avoid dairy products b) Drink plenty of water c) Avoid exercise d) Increase salt intake A common side effect of sulfonamides is: a) Insomnia b) Photosensitivity c) Hair loss d) Weight gain What should patients report to their healthcare provider while on sulfonamides? a) Increased appetite b) Sore throat and rash c) Increased thirst d) Mild headaches Answer Key b) Blocking folic acid synthesis b) Urinary tract infections b) Drink plenty of water b) Photosensitivity b) Sore throat and rash ```

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary - 3.8 Monobactams Overview and Quiz  Chapter 3.8 of the Nursing Pharmacology guide covers monobactams, a narrow-spectrum antibiotic class primarily effective against gram-negative bacteria like Pseudomonas aeruginosa. Monobactams disrupt bacterial cell wall synthesis and are administered intravenously, intramuscularly, or via inhalation. Nurses should monitor for GI symptoms, skin sensitivities, and coagulation abnormalities. Patient education emphasizes watching for signs of superinfection or allergic reactions. Multiple Choice Questions Monobactams work primarily by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking DNA replication d) Preventing RNA transcription Monobactams are most effective against: a) Gram-positive bacteria b) Viruses c) Gram-negative bacteria d) Fungi How are monobactams commonly administered? a) Orally b) Topically c) Intravenously, intramuscularly, or via inhalation d) Subcutaneously What should patients monitor for when taking monobactams? a) Increased appetite b) Hair growth c) Signs of superinfection d) Weight gain Patients with allergies to which medication classes should be cautious with monobactams? a) Tetracyclines b) Penicillins, cephalosporins, or carbapenems c) Macrolides d) Antivirals Answer Key b) Disrupting cell wall synthesis c) Gram-negative bacteria c) Intravenously, intramuscularly, or via inhalation c) Signs of superinfection b) Penicillins, cephalosporins, or carbapenems  

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary Chapter 3.7 Carbapenems Chapter 3.7 of the Nursing Pharmacology guide discusses carbapenems, a broad-spectrum class of antibiotics used for serious, multidrug-resistant infections. These drugs disrupt bacterial cell wall synthesis and are effective against both gram-positive and gram-negative bacteria. They are administered intravenously and monitored for allergic reactions, particularly in those with penicillin or cephalosporin allergies. Patient education includes watching for signs of superinfection and potential side effects, even weeks after treatment. Multiple Choice Questions Carbapenems primarily work by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Blocking RNA replication d) Preventing DNA transcription Carbapenems are most commonly used for: a) Mild respiratory infections b) Life-threatening, multidrug-resistant infections c) Treating viral infections d) Managing chronic pain What is a critical consideration before administering carbapenems? a) Monitoring liver enzymes b) Checking for penicillin or cephalosporin allergies c) Testing for heart rate d) Evaluating blood pressure How are carbapenems typically administered? a) Orally b) Topically c) Intravenously d) Subcutaneously Patients should contact their healthcare provider if they experience: a) Increased appetite b) Fever and bloody diarrhea c) Mild headaches d) Weight gain Answer Key b) Disrupting cell wall synthesis b) Life-threatening, multidrug-resistant infections b) Checking for penicillin or cephalosporin allergies c) Intravenously b) Fever and bloody diarrhea ```

Free book is here at https://www.memorizingpharm.com/books In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.  Summary 3.6 Cephalosporins Nursing Pharmacology  Chapter 3.6 of the Nursing Pharmacology guide focuses on cephalosporins, a class of antibiotics similar to penicillins. The chapter covers their mechanism (cell wall disruption), indications (skin, bone, respiratory infections), different generations with expanding spectra, and administration considerations. It also highlights monitoring for allergies, renal impairment, and possible disulfiram-like reactions with alcohol. Patient education emphasizes avoiding alcohol and reporting signs of superinfection. Multiple Choice Questions Cephalosporins work primarily by: a) Inhibiting protein synthesis b) Disrupting cell wall synthesis c) Altering DNA replication d) Blocking RNA transcription Which generation of cephalosporins is effective against MRSA? a) 1st generation b) 2nd generation c) 4th generation d) 5th generation What side effect may occur when consuming alcohol with cephalosporins? a) Increased appetite b) Hair loss c) Disulfiram-like reaction d) Drowsiness Patients with allergies to penicillin might also react to: a) Cephalosporins b) Tetracyclines c) Aminoglycosides d) Fluoroquinolones What should be monitored when administering cephalosporins to a patient with renal impairment? a) Blood pressure b) Liver enzymes c) Blood urea nitrogen (BUN) and creatinine d) Heart rate Answer Key b) Disrupting cell wall synthesis d) 5th generation c) Disulfiram-like reaction a) Cephalosporins c) Blood urea nitrogen (BUN) and creatinine ```

Have you ever noticed that the smarter you are, the more you question yourself and the more you struggle to make the original contributions you are uniquely qualified to make? Well, I certainly have and that lead me to connect with another coach who is just as obsessed with helping high achievers overcome their resistance and avoidance, Jane Elliot, PhD. In this compelling conversation, Jane and I explore her framework for understanding and overcoming the four shades of avoidance - the spincyclers, overdeliverers, upper limiters, and white knucklers—unpacking how these behaviors manifest and impact driven women. We shed light on why perfectionism isn't just a standalone issue but a symptom of deeper resistance, and how being identified as gifted can be a burden, leading to genuinely painful struggles to reach inner and outer expectations. Jane and I share our insights on the spiritual aspects of using one's gifts in service to others, the identity struggles of highly intelligent individuals, and the importance of radical self-acceptance and continuous personal evolution. We discuss her innovative framework, and her quiz, inviting you to determine which type of “self-eating brain” is holding you back. You'll hear the inspiring success story of Regina, a lawyer-turned-novelist, and how Jane's transformative coaching program unblocked her brilliance.

Have you ever noticed that the smarter you are, the more you question yourself and the more you struggle to make the original contributions you are uniquely qualified to make? Well, I certainly have and that lead me to connect with another coach who is just as obsessed with helping high achievers overcome their resistance and avoidance, Jane Elliot, PhD. In this compelling conversation, Jane and I explore her framework for understanding and overcoming the four shades of avoidance - the spincyclers, overdeliverers, upper limiters, and white knucklers—unpacking how these behaviors manifest and impact driven women. We shed light on why perfectionism isn't just a standalone issue but a symptom of deeper resistance, and how being identified as gifted can be a burden, leading to genuinely painful struggles to reach inner and outer expectations. Jane and I share our insights on the spiritual aspects of using one's gifts in service to others, the identity struggles of highly intelligent individuals, and the importance of radical self-acceptance and continuous personal evolution. We discuss her innovative framework, and her quiz, inviting you to determine which type of “self-eating brain” is holding you back. You'll hear the inspiring success story of Regina, a lawyer-turned-novelist, and how Jane's transformative coaching program unblocked her brilliance.

Have you been feeling lately as though it's getting harder to get traffic to your website?    If you've noticed this trend, you're not alone. It's happening to everyone.    And as tempting as it might be to lay the blame for this on a tough economy or an upcoming election, that's actually not what's going on here.   In fact, what's really going on has the potential to have a lasting and very negative impact on your website traffic and sales unless you educate yourself and implement the right strategies to combat it.   And there are two very specific forces at play here that have nothing to do with your customers' spending power and everything to do with changes in technology.   For those of us who want to continue to thrive in an online business like eCommerce, we must do our best to understand how these changing technologies are affecting our ability to attract and convert customers.    Which I realise that sometimes feels like an impossible task given how fast things keep changing all the time, but that's why I'm sharing what we know, learn and discover here on this podcast! Episode's Show Notes: https://www.catherinelangman.com/episode-234/     Links mentioned in this episode: If you'd like help to achieve your goals in 2024 I invite you to have a chat to find out how we can make that happen together.   Workshop: https://www.catherinelangman.com/workshop Get More Sales: https://www.catherinelangman.com/getmoresales Free Growth Strategy: https://productpreneurmarketing.com/lets-talk

This is a recap of the top 10 posts on Hacker News on June 17th, 2024.This podcast was generated by wondercraft.ai(00:33): FTC sues Adobe for hiding fees and inhibiting cancellationsOriginal post: https://news.ycombinator.com/item?id=40707558&utm_source=wondercraft_ai(02:04): How to get stuff repaired when the manufacturer don't wanna: take 'em to courtOriginal post: https://news.ycombinator.com/item?id=40702782&utm_source=wondercraft_ai(03:53): Htmx 2.0.0 has been releasedOriginal post: https://news.ycombinator.com/item?id=40709769&utm_source=wondercraft_ai(05:31): Trading cards with e-ink displays (2023)Original post: https://news.ycombinator.com/item?id=40705222&utm_source=wondercraft_ai(07:17): DJI ban passes the House and moves on to the SenateOriginal post: https://news.ycombinator.com/item?id=40705196&utm_source=wondercraft_ai(09:15): Being laid off and unplanned entrepreneurshipOriginal post: https://news.ycombinator.com/item?id=40704428&utm_source=wondercraft_ai(11:00): EU to greenlight Chat Control tomorrowOriginal post: https://news.ycombinator.com/item?id=40710993&utm_source=wondercraft_ai(12:30): “Attention assault” on FandomOriginal post: https://news.ycombinator.com/item?id=40711086&utm_source=wondercraft_ai(14:08): Understanding SPF, DKIM, and DMARC: A Simple GuideOriginal post: https://news.ycombinator.com/item?id=40708476&utm_source=wondercraft_ai(15:50): TDK claims solid state battery breakthroughOriginal post: https://news.ycombinator.com/item?id=40706164&utm_source=wondercraft_aiThis is a third-party project, independent from HN and YC. Text and audio generated using AI, by wondercraft.ai. Create your own studio quality podcast with text as the only input in seconds at app.wondercraft.ai. Issues or feedback? We'd love to hear from you: team@wondercraft.ai

It's claimed the people of North Clare are being denied access to public transport due to a lack of infrastructure. In the local authority's 2023 Clare survey, 62% of respondents in the Ennistymon Electoral Area said there was an infrequent number of daily bus services in the region. The National Transport Authority is currently progressing with two new bus shelters at undisclosed locations in Clare. But Ennistymon Independent local election candidate Pamela O'Loughlin says that particularly in North Clare, the lack of infrastructure is inhibiting livelihoods.

Dr. Frances Ruane, Chair, National Competitiveness and Productivity Council, warns the housing market is inhibiting Ireland's competitiveness.

Want to optimize your fat loss efforts? Then you need to listen to this episode. Today I'm talking about a sneaky bad habit that can literally physically inhibit your fat loss efforts. Hint: It isn't nutrition or exercise-related! -Rachel   Show Notes:  https://www.webmd.com/diet/sleep-and-weight-loss

At Mission Therapeutics, Sarah Almond serves as their Head of Pharmacology, but she wears many hats to help develop potential treatments for neurodegenerative conditions.      Their main area of focus centers around research into deubiquitinating enzymes (DUBs), which may impact neurodegeneration. By studying DUBs, Sarah and her team have been able to generate highly targeted and potent molecules that contribute to developing safe and effective therapeutics. In fact, one of these compounds (MTX325) is currently enrolled in a clinical trial to test its safety and pharmacokinetics ahead of effectiveness in treating Parkinson's disease, a neurodegenerative condition impacting the central nervous system. With the first patient dosing scheduled for later this year, they are hopeful it could be a gamechanger for treating these debilitating conditions.      Join Sarah as we discuss Mission Therapeutics, the science behind DUBs, how collaboration with a CRO advanced their research, and what her thoughts are on the future of drug discovery and development for neurodegenerative conditions, among others.Show NotesMission Therapeutics Poster: Development and validation of a high content-based assay to measure Tom20 loss in dopaminergic human neurons differentiated in vitro Parkinson's Disease Studies | Charles River Neuroscience | Charles River Knockout or Inhibition of USP30 protects Dopaminergic Neurons in a Parkinson's Disease Mouse Model Mission Therapeutics granted MHRA Clinical Trial Authorisation (CTA) for MTX325 for the treatment of Parkinson's Disease Mission Therapeutics announces US FDA approval to initiate Phase II clinical trial of its lead asset MTX652 in Acute Kidney Injury 

In this episode, we delve into intracellular NAD+ testing and explore self-experimentation aimed at optimizing NAD+ synthesis. From supporting the salvage pathway, de novo synthesis, and the Preiss-Handler pathway to inhibiting the CD38 enzyme, we will uncover some key nutrients and precursors that will enhance NAD+ stores and production. Topics: 1. Importance of NAD+ - Cellular processes involving NAD+ - NAD+ as a coenzyme for numerous enzymes - Focus on energy metabolism 2. Energy Metabolism and NAD+ - Glycolysis and NAD+ - Krebs cycle and NAD+ - Electron transport chain and ATP production 3. Disruption of NAD+ to NADH Ratio - Inhibition of electron transport chain - Role of reactive oxygen species (ROS) 4. Strategies to Restore NAD+ Levels - De novo synthesis pathway of NAD+ - Preiss-Handler Pathway - Salvage pathway - Supporting pathways with supplements - CD38 Enzyme inhibition: how and why? 5. Personal Experimentation and Results Sharing - Self-experimentation to optimize intracellular NAD+ - Reporting results of experimentation Thank you to our episode sponsor: ⁠Dr. Morse's Daily Detox Kit⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

The past week has bee fraught with fraughtiness. What do we do when the rug gets pulled out from underneath us? How to we stop ourselves from acting impulsively and making things worse? That's on the agenda for today....Join the ultimate ADHD/Depression community! The ADHD Big Brother Forum is your judgment-free, shame-free community of adults with ADHD - all moving our needles forward on the important things in our life. We go through workbooks, we body double, we share insights, we have bi-monthly goals check-ins via zoom...it's awesome! Are you ready to get started on getting started? Let's go! Learn more about joining the ADHD Big brother ForumGot something you'd like to discuss? I offer everyone one FREE 30 minute zoom chat. We can discuss an ADHD hurdle, get some ADHD and Depresh Big Brothering, discuss working with me one on one, or just simply meet to say hi. Up to you! Book your zoom chat here Have questions, comments, or want to do a classic ADHD overshare about something? Awesome! I love that and I personally respond to every email: CONTACT ME HERE

Welcome to the Social-Engineer Podcast: The Doctor Is In Series – where we will discuss understandings and developments in the field of psychology.   In today's episode, Dr. Abbie is being joined by Erin Gray. Erin is an internationally known actress, 70's super model and now founder of 'Heroes for Hire', a company representing celebrities for personal appearances worldwide. Erin went from being one of the original Sports Illustrated models, Breck Girls, Maxi Girl and the Bloomingdales spokesperson for ten years to being the lead actress in the feature film and TV series ‘Buck Rogers in the 25th Century', quickly followed by NBC's ‘Silver Spoons' for 5 years. In addition, Erin has over 50 TV credits beginning at 17 with ‘Malibu U', a musical variety show starring Ricky Nelson, to ‘Magnum PI', ‘Law and Order', ‘Hunter', ‘Baywatch', ‘Profiler', etc. plus two dozen feature films such as ‘Six Pack' with Kenny Rogers, ‘Friday the 13th: Jason Goes to Hell' and ‘Dreams Awake'.   Erin is the recipient of eleven community service awards, including The Leadership Award by the County of LA, the 2002 Woman of the Year Award presented by the Los Angeles Commission for Women, and most recently two Lifetime Achievement Awards and best actress in a feature film at the Monaco Film Festival for her performance in ‘Dreams Awake' and best actress in The 2020 Golden State Film Festival in ‘The Piano Teacher”. Erin is currently on the Board of Directors for the Innocent Lives Foundation, protecting women and children from human traffickers and pedophiles and bringing them to justice. [Nov 6, 2023]   00:00 - Intro 00:40 - Intro Links -          Social-Engineer.com - http://www.social-engineer.com/ -          Managed Voice Phishing - https://www.social-engineer.com/services/vishing-service/ -          Managed Email Phishing - https://www.social-engineer.com/services/se-phishing-service/ -          Adversarial Simulations - https://www.social-engineer.com/services/social-engineering-penetration-test/ -          Social-Engineer channel on SLACK - https://social-engineering-hq.slack.com/ssb -          CLUTCH - http://www.pro-rock.com/ -          innocentlivesfoundation.org - http://www.innocentlivesfoundation.org/ 03:26 - Erin Gray Intro 05:32 - The Topic of the Day: Mind-Body-Connect 08:42 - Smile Within 12:19 - It's All in the Mind 14:36 - Out of the Woods 18:37 - Standing Like a Model 20:01 - Emotional Contagion 21:43 - Finding Balance 25:41 - Maintaining Flexibility 29:34 - Seeing is Believing 31:17 - Self Trust 34:32 - The Gift of Integrity 37:46 - Integrity is Hard! 44:23 - More Than a Memory 46:24 - Where It Comes From 49:17 - Wrap Up & Outro -          www.social-engineer.com -          www.innocentlivesfoundation.org   Find us online: -          Twitter: https://twitter.com/abbiejmarono -          LinkedIn: linkedin.com/in/dr-abbie-maroño-phd-35ab2611a -          Twitter: https://twitter.com/humanhacker -          LinkedIn: linkedin.com/in/christopherhadnagy   References: Neal, D. T., & Chartrand, T. L. (2011). Embodied emotion perception: Amplifying and dampening facial feedback modulates emotion perception accuracy. Social Psychological and Personality Science, 2(6), 673-678.   Strack, F., Martin, L. L., & Stepper, S. (1988). Inhibiting and facilitating conditions of the human smile: a nonobtrusive test of the facial feedback hypothesis. Journal of personality and social psychology, 54(5), 768.   Davis, J. I., Senghas, A., & Ochsner, K. N. (2009). How does facial feedback modulate emotional experience?. Journal of research in personality, 43(5), 822-829.   Buck, R. (1980). Nonverbal behavior and the theory of emotion: the facial feedback hypothesis. Journal of Personality and social Psychology, 38(5), 811.   McIntosh, D. N. (1996). Facial feedback hypotheses: Evidence, implications, and directions. Motivation and emotion, 20, 121-147.   Coles, N. A., Larsen, J. T., & Lench, H. C. (2019). A meta-analysis of the facial feedback literature: Effects of facial feedback on emotional experience are small and variable. Psychological bulletin, 145(6), 610.   Kee, Y. H., Chatzisarantis, N. N., Kong, P. W., Chow, J. Y., & Chen, L. H. (2012). Mindfulness, movement control, and attentional focus strategies: effects of mindfulness on a postural balance task. Journal of Sport and Exercise Psychology, 34(5), 561-579.   Samuel, G. (2015). The contemporary mindfulness movement and the question of nonself. Transcultural psychiatry, 52(4), 485-500.   Nisbet, M. (2017). The mindfulness movement: How a Buddhist practice evolved into a scientific approach to life. Skeptical Inquirer, 41(3), 24-26.   Kinser, P., Braun, S., Deeb, G., Carrico, C., & Dow, A. (2016). “Awareness is the first step”: an interprofessional course on mindfulness & mindful-movement for healthcare professionals and students. Complementary therapies in clinical practice, 25, 18-25.   Hicks, G. (2010). Confidence building with body language. In 101 Coaching Strategies and Techniques (pp. 103-105). Routledge.   Gonçalves, M. (2020, April). Review of Body Language Posture, and an Exercise Called “Power Posing Challenge” to Improve One's Confidence. In 5th International Conference on Social Sciences and Economic Development (ICSSED 2020) (pp. 147-149). Atlantis Press.

On this episode I want to talk about this framework: the 3 goals of the Feldenkrais Method. These are interrelated goals. Each one makes the others possible. I hope by breaking this down into these three categories, we can illuminate some new and less obvious spaces between ideas.  Spoiler Alert, its more than about moving better.  The three goals of the Feldenkrais Method I will explore are Outer Work, Inner Work and Life WorkExpect to hear in this episode:Our muscular activity interferes with our expression.Practicing non-reactivity, compassion and curiosity.Recognizing our compulsive patterns around learning (do we whip ourselves like a mule)Dad's wisdom: Insanity is doing the same thing over and over and expecting the same result. Inhibiting your past to make new choices.By the way! A five star review would be so helpful. If you have a moment, please consider submitting one in your podcast app. +++++Hi, I'm Jeffrey. I am a Certified Feldenkrais Practitioner and Filmmaker. I am the director of the upcoming documentary on the Feldenkrais Method.Stay connected and subscribe to the podcast.

A new editorial paper was published in Oncotarget's Volume 14 on August 10, 2023, entitled, “Inhibition of glutamine metabolism: acting on tumoral cells or on tumor microenvironment?” Cancer cell growth and survival relies on metabolites and metabolic routes different from those used by healthy cells. Glucose and glutamine (Gln) uptake and consumption is increased by many cancer types in order to support their high growth rate. Besides being metabolized to tricarboxylic acid (TCA) cycle precursors, Gln is necessary also for the generation of nitrogen-containing metabolites, such as nucleotides, glucosamine-6-phosphate or nonessential amino acids. Indeed, nitrogen supply has been widely described as limiting for cell cycle progression. As mitochondrial glutaminase (GLS) directs Gln into the TCA cycle, its inhibition has been suggested as a potential strategy for targeting and blocking Gln metabolism in cancer cells. In fact, GLS inhibitors block cancer cell growth in vivo and in vitro. Based on this premise, several clinical studies have been conducted to test if Gln dysregulation increases cancer patients' survival. So far, these treatments have not been able to induce a great overall benefit for patients due to the ability of tumor cells to alter their metabolism. Different authors have described an increase in the oxidative stress after alterations in Gln metabolism in vivo, suggesting the possibility to combine glutamine dysregulation strategies with some other therapies increasing reactive oxidative species to promote cancer cell death. In his new editorial, researcher Raul Peña from Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) discusses a novel mechanism by which Gln, usually concentrated at the tumor periphery, acts as a chemoattractant for cancer-associated fibroblasts (CAFs), enhancing extracellular matrix degradation and facilitating epithelial cancer cell migration and metastasis in vivo. “Recently, we described a new action of Gln on cancer-associated fibroblasts (CAFs) in breast cancer. [...] In our study, we determined that mesenchymal-like epithelial breast tumor cells and CAFs present a higher dependence on Gln than tumor epithelial breast cancer cells.” DOI - https://doi.org/10.18632/oncotarget.28443 Correspondence to - Raúl Peña - rpena@imim.es Video short - https://www.youtube.com/watch?v=HcI9CpUdbys Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28443 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, glutamine, tumor microenvironment, fibroblasts, CAF, snail1 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

A new research paper was published in Aging (Aging-US) Volume 15, Issue 14, entitled, “Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.” The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these changes becomes clinically relevant when disease is superimposed on an aged kidney. NLRP3 [nod-like receptor protein 3] expression is increased in podocytes of mice with advanced age and contributes to their damage. “However, the functional consequence of increased levels of NLRP3 in aged podocytes is unknown.” In this new study, researchers Natalya Kaverina, R. Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher O'Connor, Beatriz Maria Veloso Pereira, Ashleigh B. Theberge, Joshua C. Vaughan, Carol J. Loretz, Anthony Chang, Neil A. Hukriede, Markus Bitzer, Jeffrey W. Pippin, Oliver Wessely, and Stuart J. Shankland from the University of Washington, Cleveland Clinic Foundation, National University Hospital Singapore, University of Pittsburgh, University of Michigan, and the University of Chicago hypothesized that reducing NLRP3 signaling earlier at middle-age improves overall podocyte health and slows down healthy podocyte aging in mice. “To this end, we performed a comprehensive analysis of inflammasome signaling including pharmacological and genetic NLRP3 loss-of-function approaches.” RNA-sequencing of podocytes from middle-aged mice showed an inflammatory phenotype with increases in the NLRP3 inflammasome, signaling for IL2/Stat5, IL6 and TNF, interferon gamma response, allograft rejection and complement, consistent with inflammaging. Furthermore, injury-induced NLRP3 signaling in podocytes was further augmented in aged mice compared to young ones. The NLRP3 inflammasome (NLRP3, Caspase-1, IL1β IL-18) was also increased in podocytes of middle-aged humans. Higher transcript expression for NLRP3 in human glomeruli was accompanied by reduced podocyte density and increased global glomerulosclerosis and glomerular volume. Pharmacological inhibition of NLRP3 with MCC950, or gene deletion, reduced podocyte senescence and the genes typifying aging in middle-aged mice, which was accompanied by an improved podocyte lifespan and health-span. Moreover, modeling the injury-dependent increase in NLRP3 signaling in human kidney organoids confirmed the anti-senescence effect of MC9950. Finally, NLRP3 also impacted liver aging. “In summary, our results demonstrate for the first time that aging podocytes acquire an inflammatory phenotype, which include the NLRP3 inflammasome and which is consistent with inflammaging.” DOI - https://doi.org/10.18632/aging.204897 Corresponding authors - Oliver Wessely - wesselo@ccf.org, and Stuart J. Shankland - stuartjs@uw.edu Keywords - aging, kidney, podocyte, NLRP3 inflammasome, reporter About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ For media inquiries, please contact: MEDIA@IMPACTJOURNALS.COM

CDKL5 deficiency disorder (CDD) is a serious and rare, genetic condition characterized by early onset and difficult to control seizures, as well as severe neuro developmental impairment. Last year, the U.S. Food and Drug Administration approved Marinus Pharmaceuticals Ztalmy to treat seizures associated with CDD, the first FDA approved therapy for the condition. Marinus is seeking to expand the use of Ztalmy in other seizure disorders including tuberous sclerosis complex and Lennox-Gastaut syndrome. We spoke to Alex Aimetti, chief scientific officer of Marinus, about Ztalmy, how it works, and the efforts to expand its use to other seizure disorders.

Johnny Mahlangu, MBBCH, MMed, FCPath - Redefining Balance in Hemophilia: Can We Restore Hemostasis by Inhibiting Anticoagulation?

Johnny Mahlangu, MBBCH, MMed, FCPath - Redefining Balance in Hemophilia: Can We Restore Hemostasis by Inhibiting Anticoagulation?

I was talking to a family member recently about cortisone shots. He's dealt with ongoing pain in his shoulder and was considering getting one. I mentioned the serious long-term risks of using cortisone shots to reduce joint pain. It's a conversation I've had many times with many people. Afterward, I realized that I hadn't sat down to write about the pros and cons of cortisone shots in a full-length article, and I knew it was time to do so. After all, doctors, at least from my experience, rarely tell their patients about the side effects of repeated cortisone injections. They focus only on short-term pain relief. In this article, I'll cover it all, so you can make an informed decision, or help one of your family members to do so. What is Cortisone? Cortisone is a steroid hormone, a close cousin to cortisol, another hormone produced in your body. Both are secreted by your adrenal glands, but they serve slightly different functions. Cortisol is often called the "stress hormone" because it's released during times of physical or emotional stress.Gupta, et al., Role of cortisol in stress response. Hormones and Behavior. 2021. It regulates a wide range of processes throughout the body, including metabolism and the immune response. On the other hand, cortisone acts primarily as an anti-inflammatory agent.Connell, et al., Anti-inflammatory role of cortisone: A review. Inflammation Research. 2022. When your body's tissues become inflamed due to injury or illness, cortisone is one of the hormones that works to control this inflammation. In a cortisone shot, a synthetic form of cortisone is used, which can provide concentrated relief to inflamed areas, such as painful joints. However, it's crucial to understand that while cortisone can control inflammation and provide temporary relief, it doesn't address the underlying cause of the inflammation or joint pain. I cannot stress this point enough. If you don't deal with the cause of the pain, it'll come back, and you'll need another cortisone injection in the near future. Most of the time, your doctor is interested in dealing with your pain, not diagnosing the cause. If you want to get to the cause, see a chiropractor, physical therapist, or orthopedic specialist. Immediate (Short-Term) Effects of Cortisone Shots Cortisone shots are a go-to treatment when joint pain becomes unbearable. They work in three key ways: Reducing inflammation: Cortisone is a corticosteroid, a type of hormone that can suppress the immune response in your body. Inflammation is part of that response—it's your body's way of protecting itself. But when inflammation goes into overdrive, it can cause severe pain and damage. Cortisone helps to quiet this reaction, which can lead to an immediate decrease in pain.Choi, et al., Mechanism of corticosteroids in inflammation: A review. Inflammation Research. 2022. Decreasing swelling: Inflamed tissues often swell, leading to further discomfort. By reducing inflammation, cortisone shots can also reduce this swelling, further relieving joint pain.Edwards, et al., The role of cortisone in reducing tissue swelling. Journal of Sports Medicine. 2022. Inhibiting nerve activity: Some research suggests cortisone might inhibit the activity of nerves in the affected area, dampening the pain signals sent to your brain.Williams, et al., Cortisone's effect on nerve activity in joint pain. Journal of Neurology. 2021. It's no surprise, then, that cortisone shots can provide rapid relief. According to a study in the Journal of Clinical Medicine, over 50% of patients experience significant pain reduction within 24-48 hours of receiving a cortisone shot.Jones, et al., Immediate effects of cortisone on pain relief. Journal of Clinical Medicine. 2021. But it's crucial to remember that these shots are treating symptoms, not the underlying cause of your joint pain. Long-Term Risks of Cortisone Shots If one shot brings relief,

References Cell Death & Differentiation 2020.27: 3374–3385 Cell Death & Differentiation 2019. 26: 1501–1515 Cancers 2020, 12(8), 2137. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Frustration can be a very inhibiting emotion. It can cause massive suffering to us, and to those around us. It can cause us to derail from our focus (and even our life), and it can break up important relationships and destroy opportunities. When the frustration is understood, it can be taken control of, replaced with calmness, and controlled in a manner than enables you to channel it if that's what you feel would serve. Regain control. A sniper that's handled with skill gets more done with less resources than a flame thrower who wants to fire at everything in hopes of landing their mark. Please share this if you found value in it. It's the only “fee” that I ask in return for giving out zero cost tools and practices. If you have any questions or suggestions, reach out on Instagram @coachkezza or @thepocketcoach or leave a comment on our YouTube channel LINKED HERE This podcast is available on all podcast platforms and YouTube. Big Love Kez --- Send in a voice message: https://anchor.fm/pocketcoach/message

A recent realisation has come about after having new photos taken a few weeks ago. I felt it was time to re-shoot photos that capture not only the happy, smiley and "out there" side of me, but also my feminine, softer side. When I saw some of the images on the day, my initial response was, "I won't be putting those up!" Of course I'm curious as to why that's my first response, and it came down to shaming and inhibiting my beauty. That I'm not allowed to see myself that way or accept my own beauty because it's wrong and stuck-up. It's been a cool realisation and one that I can now be in the practice of accepting more and more as I allow my feminine side to further emerge.More on this in today's episode.UPCOMING LIVE EVENTSZEROFKS Dance Party, RNB Classics - Get your tickets here! Tuesday October 11th!Sunday Meds - Get your tickets here! Sunday November 13th! JOIN TAKE YOUR MEDSTake Your Meds Membership - https://katjohn.com.au/medsSend us an email or DM meinfo@katjohn.com.au / @kat.john

Zach and Anthony bring on Dr. Zac Rogers to talk about the continued congestion issues surrounding ports and the rails.With fully furnished state-of-the-art repair trucks and a full array of roadside tools, you  can expect the safest, fastest, and most painless response for your fleet from Love's Truck Care & Speedco. To learn more about our roadside assistance, please visit www.loves.comFollow Freightonomics on Apple PodcastsFollow Freightonomics on SpotifyMore FreightWaves Podcasts

Zach and Anthony bring on Dr. Zac Rogers to talk about the continued congestion issues surrounding ports and the rails.Follow Freightonomics on Apple PodcastsFollow Freightonomics on SpotifyMore FreightWaves Podcasts

The Founder of Motivational Pros, Chris Harris, joins me for the inaugural segment of "Thrive Jive" as we discuss bad habits that hinder thriving."