Podcast appearances and mentions of jeffrey gordon

Tunnel vision can be the ultimate enemy of justice. In this riveting exploration of the Margaret Ebbe murder investigation, we reveal how a questionable FBI profile led detectives down a singular path focused on former university employee Charlie Stone, potentially blinding them to other suspects and evidence.The Ebbe family, desperate for answers about their mother's brutal killing, hired private investigator Thomas Reed, who embarked on a costly and ultimately absurd pursuit of Stone. From staking out his Pennsylvania residence to ordering pizzas from the Domino's where he worked just to interact with him, Reed's investigation reads like dark comedy—expensive hours billed with nothing substantial to show for the effort.Meanwhile, the case took a devastating turn when Metropolitan Detroit magazine published "The Two Mrs. Ebbes," a cruel article that painted a lurid and largely fictional picture of the victim's personal life. Based heavily on the FBI profile and questionable sources with personal grudges against Ebbe, the article suggested she had willingly participated in bondage with her killer—a narrative that shattered her family and misled the public.What makes this case particularly troubling is how the FBI's behavioral science unit was credited with solving previous high-profile cases when there's little evidence they contributed. Yet their profile in the Ebbe case was treated as gospel, narrowing the focus of the investigation dramatically while potential leads went unexplored. Despite Flint Police maintaining an impressive clearance rate for homicides during a record-breaking year of violence, the Ebbe case remained frustratingly open.As the episode introduces us to Art Ludwig and his wife Nancy Lepore, new threads begin to appear in this complex mystery. Their seemingly perfect life together creates an intriguing counterpoint to the main investigation, suggesting connections that will become clear as Jeffrey Gordon's deadly secrets continue to unfold.Have you ever wondered how a murder investigation can go wrong despite the best intentions? This episode shows exactly how confirmation bias and overreliance on profiles can derail the pursuit of justice. What would you look for if you were investigating this case?Send us a text Support the show

In a fascinating conversation with Professor Max Nieuwdorp of the Amsterdam Medical Centre, Dr James McIlroy explores groundbreaking ideas and research surrounding the microbiome, hormones, and their profound impact on metabolic diseases. This insightful dialogue uncovers the remarkable potential of faecal microbiota transplant (FMT) and emerging pharmaceutical strategies in tackling obesity, diabetes, and even cancer. Timestamps: 00:00 Introduction to Professor Max and the Podcast 02:04 Max's Journey into Microbiome Research 05:06 The Power of Fecal Microbiota Transplantation (FMT) 08:11 Microbiome's Role in Obesity and Metabolic Health 10:42 Challenges and Future Directions in Microbiome Research 14:47 Defining Obesity and Its Genetic Factors 18:39 FMT and Its Impact on Various Diseases 23:48 Optimal Diet for a Healthy Microbiome 31:07 The Power of Combining Probiotics 31:36 The GLP-1 Story: A Deep Dive 32:30 Mechanisms and Effects of GLP-1 Drugs 37:26 The Role of Microbiome in Weight Management 39:18 Selecting the Best Donor for FMT 42:27 Impact of Diet on Microbiome and Health 50:17 Future of Microbiome Research and Therapies 56:13 The Power of Hormones: Book Insights   The Journey into Microbiome Research Professor Nieuwdorp's interest in the microbiome began serendipitously during his postdoctoral studies at UCSD. There, he encountered revolutionary ideas, particularly through the work of Jeffrey Gordon, which highlighted the significance of the microbiome long before it became widely acknowledged. An unforgettable early success with FMT on a patient with Clostridium difficile infection set the foundation for his enduring commitment to this field. Over the years, Nieuwdorp has been involved in pivotal studies, evolving his understanding of how microbiome therapies could be used in metabolic diseases and beyond. Understanding FMT and Its Role FMT has shown remarkable efficacy, especially in treating infections like Clostridium difficile. The discussion highlights an astounding 90% cure rate demonstrated in early trials, a feat Nieuwdorp describes as "seminal". Nonetheless, expanding this success to metabolic conditions such as obesity and autoimmune diseases remains a promising, yet ongoing, challenge. The Nexus Between Microbiome and Obesity While the connection between the microbiome and obesity remains a complex issue, Nieuwdorp emphasises how the microbiome's role in weight control is likely more significant over the long term—akin to directing an oil tanker—than as a quick fix. The conversation delves into why the body finds it easier to gain weight than to lose it, considering genetic predispositions and evolutionary pressures. This adaptability of the microbiome, combined with dietary habits, may significantly influence how our bodies metabolise and store energy. Revolutionary Treatments on the Horizon Emerging pharmacological treatments such as GLP-1 agonists are causing waves in medicine. These drugs, alongside the potential of next-generation probiotics, promise to reshape how obesity and associated conditions are treated. Intriguingly, research continues to suggest the microbiome might itself produce GLP-1, hinting at a future where therapies target these microbial mechanisms directly. The Path Forward: Microbiome as a Predictive Tool Professor Nieuwdorp envisions a future where microbiome profiling becomes a standard diagnostic and preventative tool. It has the potential to predict disease susceptibility, allowing for earlier and more personalised interventions. In parallel, the continued development of FMT and its derivatives may revolutionise treatments for a range of conditions, from cancer to metabolic disorders. The Educational Perspective: "The Power of Hormones" In addition to his pioneering research, Nieuwdorp shares insights in his book, The Power of Hormones, presenting a layperson's guide to understanding hormones across a lifespan. This book interweaves historical narratives with scientific discussion to elucidate how hormones and the microbiome intersect in influencing daily life. This extensive dialogue with Professor Nieuwdorp is a testament to the potential of microbiome science and the exciting horizon that awaits both researchers and patients. As innovations continue, integrating microbiome knowledge with traditional medical interventions could profoundly change how we understand and treat human health.

In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]

In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]

In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]

In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]

In this program, Dr. Jeffrey Gordon, Director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University and the Scripps Institution of Oceanography's 2024 recipient of the Nierenberg Prize for Science in the Public Interest, discusses his research into the microbiome. Gordon is credited with founding the field of gut microbiome research. His transformative studies have demonstrated that human health and disease are shaped by the communities of microbes that live in the human gut. His body of work has opened up the vast new therapeutic potential for the microbiome, exemplified by his identification of ways to repair the gut microbiomes of children with malnutrition and restore their healthy growth. Series: "Science in the Public Interest" [Health and Medicine] [Show ID: 40154]

Jeffrey Gordon, MD, often called “the father of microbiome research,” is the 2024 recipient of the Mechthild Esser Nemmers Prize in Medical Science.  In this episode, Gordon discusses the impacts of his long career in gut microbiome research, which has profoundly transformed our understanding of human health. Specifically, he shares the evolution of groundbreaking approaches to treating malnutrition and childhood undernutrition with microbiota-targeted therapies.

Dr. Tahmeed Ahmed, MD, PhD is Executive Director of the icddr,b ( https://www.icddrb.org/ - formerly known as the International Centre for Diarrhoeal Disease Research, Bangladesh), an organization committed to solving public health problems facing low- and middle-income countries through innovative scientific research – including laboratory-based, clinical, epidemiological and health systems research. By developing, testing and assessing the implementation of interventions specifically designed for resource-poor settings, they aim to improve the health and wellbeing of people living in the world's poorest nations. Dr. Ahmed has been working for the last three decades in simplifying the management of childhood malnutrition, childhood tuberculosis, and diarrheal diseases. He leads the BEED (Bangladesh Environmental Enteric Dysfunction) study that attempts to discover non-invasive biomarkers of environmental enteric dysfunction, an important cause of stunting in children. Together with Dr Jeffrey Gordon of Washington University in St. Louis he discovered microbiota directed complementary food (MDCF) - a novel intervention for childhood malnutrition. This discovery was highlighted by the prestigious journal Science as one of the scientific breakthroughs of 2019. He is continuing the research on MDCF with support from the Bill & Melinda Gates Foundation. Dr. Ahmed studied in St. Gregory's High School and Notre Dame College, Dhaka and then obtained his medical degree from Mymensingh Medical College. He received residential training in Dhaka Children's Hospital and subsequently studied at the University of Tsukuba in Japan for his PhD. He has recently been appointed the Executive Director of icddr,b where he has been working for the last three decades. As a member of the Nutrition Guidance Expert Advisory Group of the WHO, Dr. Ahmed revised the global guidelines for management of childhood acute malnutrition. He advises the Global Task Force on Cholera Case Control (GTFCC) on case management of cholera in children. Dr Ahmed was awarded the Bangladesh Academy of Science - Dr Sultan Ahmed Choudhury Gold Medal for outstanding achievement in Medical Science in 2003. He received from the Honorable Prime Minister of Bangladesh, Sheikh Hasina, the Islamic Bank Development Transformers' Roadshow Award in 2018. Dr Ahmed works closely with the Ministry of Health of Bangladesh, WHO, UNICEF and the International Atomic Energy Agency in research, policy issues and training on nutrition. He has more than 400 papers published in international journals and books. Dr Ahmed was the President of the Commonwealth Association of Pediatric Gastroenterology and Nutrition (CAPGAN), an association of professionals in Pediatric Gastroenterology and Nutrition from the 54 Commonwealth nations. He is Professor of Public Health Nutrition of James P. Grant School of Public Health, BRAC University, Dhaka and also Affiliated Professor of School of Global Health, University of Washington, Seattle. Dr Ahmed has recently been appointed Honorary Senior Fellow of the Bangladesh Institute of Development Studies (BIDS). Social Media - icddr,b - icddr,b Twitter - https://twitter.com/icddr_b/ icddr,b LinkedIn - https://www.linkedin.com/company/icddrb/ Support the show

If you've heard it once, you've heard it a thousand times.  Insurance gets easier when you can speak the language better than the next guy.  But did you ever think that fluency was more important than insurance knowledge and experience? Well, that's where things get interesting, and you might be surprised at how important talking the talk is with truckers.  Jeffrey Gordon, President at The Bayou Agency, talks about why the insurance is the insurance and how he's taking his transportation clients to the next level. 

If you want to improve your digestion, your immune system, and your overall health, one might begin with a focus on a healthy gut microbiome. Today we're talking with Stanford University professor of microbiology and immunology Dr. Justin Sonnenburg, co-author of the book entitled, "The Good Gut: Taking Control of Your Weight, your Mood, and Your Long-Term Health." He and his wife, research scientists Dr. Erica Sonnenburg, argue that our typical modern diet has caused the microbial diversity or intestine to shrink substantially. Turns out that's a big problem. Interview Summary My impression is that this field of work on the microbiome is just exploding. It seems like every day something new comes out, something exciting, some kind of major breakthrough. It's wonderful to have a leading scientist like you to join us to help explain this. Let me begin with this question. I recently read something very interesting in the article that discussed your work, namely that you've hypothesized, and this is a quote from this article, "Humans may merely be elaborate vessels "designed for the propagation of bacterial colonies." Now that's pretty interesting. Tell us more if you would? Yes, absolutely. I should note that this is an idea that has been propagated, just as microbes are propagated over time. I did say that, but I'm now attributing it to the great scientists that came before me. I will say that the microbes in our gut have been for a long time a curiosity. For hundreds of years we've known that they live there. Over time we've learned that they're affected by what we eat. We know that they're involved in digestion and gut health. But what is really phenomenal is, as you alluded to in the introduction just the ability of these microbes to impact so many dimensions of our health. Everything from our immune system, to metabolism, to things like moods, behavior, and neurodegeneration. When you start to think about microbes getting passed from generation to generation - because as a new baby is born, their gut is sterile in the womb, and then they're rapidly colonized when they come to this world largely by microbes from their mother and other adults around them - you start to realize that these microbes may actually be the ones calling the shots and dictating aspects of our biology to promote their growth through evolutionary time. It does change the way you think about this relationship in some ways. One might jump to the conclusion that microbes are a bad thing, and you'd like to have fewer of them. That's in fact what antibiotics do, they get rid of them. But we need more rather than less, and it sounds like the shrinking diversity of the microbiome is really a problem. How do our diet and lifestyles damage the vitality of the human microbiome? I'm imagining this is a 'let me count the ways question,' but what are the leading concerns in your mind? Yes, completely. I think you're right in that it's very hard to single out one particular factor, because as populations become more industrialized and embrace all of the technologies and medical practices that go along with the industrialized lifestyle, we have so many factors that can impact our microbiome. Certainly, diet is a major factor, and we can come back to this. But we know that most of the microbes in our gut reside at the far reaches of our digestive tract - at the very end of the line down in our colon in our large intestine. That means that if we're eating simple nutrients, like most of the things in a western diet - sugars, starch, fat, protein - a lot of those things get digested and absorbed in our small intestine, which leaves nothing remaining for the microbiota. It's really complex carbohydrates and dietary fiber, that serve as the major fuel for the microbiota because we can't digest those complex carbohydrates. The western diet has greatly reduced dietary fiber content, which has left a lot of our gut microbes starving. But there are other aspects of diet, certainly artificial sweeteners, emulsifiers, and probably the high fat content of the western diet are not great for our microbiome. Then beyond diet, antibiotics as you mentioned known to be great for fighting infectious diseases, but not so great for maintaining all of the friendly microbes that we harbor in our body. A variety of other factors like C-sections, baby formula, the incredible sanitation in our environment, again, a lot of these things are a trade-off because we have reaped a lot of benefits from a lot of the lifestyle medical practices technologies. But at the same time, we've implemented these in the absence of understanding the importance of our gut commensals, and the other commensals on our body for our health. Now we really need to start thinking about do we need to restore diversity to this community? Certainly, we need to start thinking about taking care of the community more diligently. You mentioned in some detail how diet affects the gut, but how does it happen in the reverse? Is there a reciprocal relationship going on? Yes, it's a great question, and there are some papers that have been published looking at how gut microbes can affect food choice in model organisms like fruit flies and other organisms that are studied in the lab. We know that microbes in the gut as they metabolize things are producing a lot of interesting chemicals, little metabolites that get absorbed into our bloodstream can circulate through our body. Certainly, some of them cross the blood-brain barrier and can interact with our central nervous system. Now, whether some of those molecules can actually impact our food choice, I think is an interesting topic, we don't know a lot about that. You can imagine a microbe that's really good at, for instance, degrading pectin and it might grow very well. We know there are many microbes that grow well when we, for instance, eat an apple. If that microbe happens to produce a molecule just by chance that then can go in and increase our craving for an apple, that microbe has hit the jackpot for proliferating, it can guide our actions to choose an apple and then it actually profits from the pectin that comes in when we eat the apple. While this would be a very rare quirky event to happen, when you think about the trillions of microbes that exist in every person and have existed in every person across the planet throughout time. It's possible that things like this have happened, and it's a matter of us as scientists trying to track down those stories. There's at least some optimism that there could be virtuous cycles that gets set up rather than these destructive cycles potentially. Help us place this in some sort of a context. You talked about a myriad of dietary things that could affect the microbiome, and probably other things out there in the world too. How serious is the impact? Yes, and this brings up kind of the question of what is a healthy microbiome? Has lifestyle impact that our microbiome? What would be ideal would be to have a time machine to go back, and actually survey what the microbiome looked like thousands of years ago before industrialization, and maybe even going back greater than 10,000 years to what our gut microbiome looked like when we were hunter-gatherers even before we started farming. Just to get a sense of what are the microbes that humans harbored over long periods of time during our evolution with the idea that perhaps our human genome was shaped over evolutionary time in some way by these microbes, that we have adapted our human biology to deal with the specific set of microbiome features or species. We don't have a time machine, but there have been groups that have surveyed paleo feces for instance - the fossilized stool from humans from 1 to 2000 years ago. These data indicate that the microbiome has changed drastically. As we have industrialized, we have totally departed from this more ancestral microbiome. The other way that we can gain insight into this is by looking at modern humans that live lifestyles similar to our ancestors. Hunter-gatherer populations and rural agriculturalists, and we've done a lot of work studying the Hadza hunter-gatherers of Tanzania looking at their gut microbiome. That exactly supports what the paleo feces have told us. That there were features in the microbiome from before industrialization that have changed drastically. We've lost species, they've gone extinct. Hunter-gatherers and many rural populations still harbor these microbes. We expect that there's probably around 500 to 1000 different species of bacteria in an individual's gut microbiome. We've lost hundreds of these species over the course of industrialization. Then, the flip side of that is hundreds of other species have come in and replaced them. We've actually had this kind of wholesale change in configuration in our gut microbiome, and what this means to our biology, we're trying to figure out right now, but it is a really marked change. I have to say I admire the breadth of your work all the way from basic laboratory studies to in the field studies with hunter-gatherers. I could see how your big picture view of this is really pretty unique. Let's talk about how the gut communicates with the brain, and does the health of the microbiome affect things like eating regulation? We've talked about that a little bit already, but also things like mental health. I just want to start by saying that this is a field of research that is in very early days still, we have a lot of work to do to really figure out the connections. You can imagine then the gut microbiome composed of hundreds of species, and then trillions of cells and changing over time within an individual, and different between individuals, and then secreting thousands of chemicals that go into the bloodstream. Then put on top of that the complexity of the central nervous system and brain, and then try to map the interactions between the microbiome and the central nervous system is exceedingly complex.  I think that one of the really important things to note here is that if you look at a lot of the anxiety, and depression, Alzheimer's disease, neurodegeneration in general at this center of a lot of these diseases much like other diseases of the industrialized world lies inflammation. The immune system actually becoming too inflammatory, and that leading to, you know, in some cases autoimmune diseases, but in other cases Alzheimer's disease, and/or anxiety and depression. One of the things that our lab is focused on is really trying to understand how when you change the gut microbiome, how does the immune system change? How does the inflammatory status change of the system? Because we really think that this is the key mediator of many of the things that have gone wrong including things like diabetes and metabolic syndrome.  We're now at the point of understanding that certainly if you go into an animal model and you change the gut microbiome in a major way like industrialization has changed the microbiome of people living in the United States, you completely change how the immune system functions. You can really change how an individual would react to a respiratory infection, how well they would respond to an immunotherapy if they were battling cancer, you can just completely change immune system functionality. In trying to understand this better we've started to do dietary interventions in people to see if we change the gut microbiome in beneficial ways with diet, can we make the immune system less inflammatory? We've done this so far in healthy adults, and now we're really interested in extending this into all sorts of populations that are suffering from different inflammatory diseases, including things like anxiety, and depression, and neurodegenerative diseases. We'll have more information about this. There's some beautiful fundamental research out there that shows unequivocally that the gut microbiome is regulating behaviors, and cognition, and fundamental aspects of what happens in our brain. But a lot of this has been done in animal models, and it's very hard to extend to humans in a detailed way. I can't wait to see these studies, they're just absolutely fascinating and so important. You know, something occurred to me as I was thinking about this, and this may be outside the area of work that you're focused on, but there's a lot of interest out there in the world and the impact of endocrine disrupting chemicals, or things that leach from plastics and things known as forever chemicals, and their impacts on a whole host of things like cancers, and obesity, diabetes and more. Is there any reason to worry about the microbiome in this context? Yes, completely. I think everything that we come in contact with, particularly things that we ingest, but even things that are absorbed through our skin or we inhale, the microbes that live in and on us are just incredibly sensitive detectors of everything going on in the environment. I mean, their survival depends upon it. One of the, in fact, key features of one of the first species from the gut microbiome to have its genome sequenced, Bacteroides thetaiotaomicron this is a bacterial species that was sequenced in the lab of Jeffrey Gordon, it was published in 2003. One of the key interesting features of that genome was the expansion of environmental sensors that were encoded by that genome. It was very clear that this bacterium was living in a dynamic environment, and having to sense and respond to minute to minute variations in the chemical cues that were coming in. That means that when you start to change those chemical cues, you start to change the function of the microbiome because those sensors that those bacterial encode are wired into their function and how they behave. This is again, hypothesis, but I think your question is a a great one because there are these realms of inquiry where we are just right at the beginning of understanding that major things that are going on in our environment could be impacting this really essential component of our biology. And we really have no specific idea of how the perturbations may cascade through our microbiome and our biology. A lot to look at there, but I have no doubt that those chemicals are having an impact on this community filled with environmental sensors. It's going to be so interesting to see that work take shape. It would be great if community of people working on the microbiome could come together with the people in interested in the impact of these forever chemicals on health so that a full picture of their impact can get painted. So what do you think are the most pressing scientific questions that need to get addressed? I think that we're still really searching for the definition of a healthy microbiome. And this is something that dates back to a wonderful project that was started by the National Institutes of Health, the Human Microbiome Project. That was an effort from sequencing centers that had sequenced the human genome to turn these sequencing technologies to this uncharted aspect of our human biology, our microbiome. One of the goals of that sequencing project was to determine what a healthy gut microbiome is. And our assumption at the time was, well, we should sequence a bunch of healthy Americans, and kind of look at what's common between them. We now understand that the healthy American most likely harbors a microbiome that is not really optimal for health, it's actually probably a microbiome that's predisposing us to a number of inflammatory conditions.   Our human genome probably dictates whether you as a person will get an autoimmune disease, or cancer or you know, a different inflammatory disease. But it's really a microbiome that appears to be pro-inflammatory, and so that doesn't mean that it's terrible and that we need to scrap the whole thing. But it means that it probably can be improved. A big part of that improvement probably can come through feeding it better food and getting better functionality out of the microbes we have. But it also probably means that we need to bring back certain functions or certain species that we've lost over the course of industrialization, to bring back some of that biodiversity.  You know, I think of the microbiome as similar to this complex rainforest, just hundreds of species interacting in this really dynamic way, and as you start to degrade that ecosystem it's really hard to maintain its full functionality. You start to lose functions, and it starts to operate suboptimally. And so thinking about ways to bring back the health and biodiversity of this ecosystem, I think is super important. One of the key things that we have to do as a field, and I want to just reflect back on the work that we're doing with hunter-gatherers and implications for what might be a healthy microbiome. It is not at all clear that all of the microbes that we've lost are healthy and need to be reinstalled in our gut. I think that we've probably lost species that we, you know, just as soon not have. But mapping which ones are health-promoting, and in which context, because you know, what's health-promoting for one person may not necessarily be health promoting for someone else that's going through something very different in their life in a different life phase. So we need to understand all that complexity, and really crystallize how can we optimize a microbiome for an individual in a given context.  This sounds like a really complex problem, and it is, but I think that one of the really exciting things that's happening in the field right now is this combination of what we call omics data, the ability to measure so many different aspects of the microbiome at one time so we can get a really detailed picture. Then all the great computational approaches for bringing all that data together, using things like machine learning and artificial intelligence on big data sets to really distill out meaningful signals that give us a better idea of some of these complex questions. It is a complex thing to go after, but I think it's not out of reach and that's I think the big frontier for the gut microbiome. Well, speaking of the big frontier, let's end with a big picture question. What can be done to make things better? You mentioned improving diet would be one thing, but how do you look at those big picture questions? One of the incredible things about the gut microbiome and its relationship to its human host, is this like feedback system. For instance, if you are in a slightly inflammatory state, it can be hard to get out of that inflammatory state because the inflammation is reinforcing microbes that are then reinforcing the inflammation. You end up with these feedback loops that are very hard to break, so even if you were to do something like a fecal transplant in some instances of inflammation where you try to reinstall healthy microbes, those may not engraft and take up residence because the host inflammation will get rid of the good microbes and select in the microbes that feed the inflammation. There are these feedback loops that are very hard to break, and we know the gut microbiome is very resilient, so you can perturb it and it will by and large return to a starting state, not exactly what the starting state was, but there is this great resilience and recalcitrant to change over short time periods. This is why industrialization has been so powerful because it's happened over multiple generations across an entire population, and it's driven our microbiome in one direction.  I think if we want to bring back a more diverse healthy microbiome, it requires changes in our habits, changes in what we eat day after day for years on end to really change the species that are in our microbiome and what those species are doing. We got a little bit of insight into this, but I'll finish with one specific example. One of the dietary interventions that we did, we compared a high fiber diet, so this is eating things like legumes, whole grains, vegetables, fruits, thinking that that would be kind of optimal food for a healthy gut microbiome. We compared that diet with a high fermented food diet, so another cohort of individuals, we gave kombucha, kefir, yogurt, kimchi sauerkraut, food with living microbes in it that had been transformed by fermentation. Basically, so these were just healthy adults we let them eat those foods, they ramped up on the foods for four weeks, and then for six weeks they maintained high levels of those foods. We actually saw that the high fiber diet had very different effects on individuals depending upon their starting microbiome. If you had a very diverse microbiome to start with, you actually improved your inflammatory status, you got less inflammatory over the course of the intervention. But if you start with a low diversity microbiome, the high fiber diet doesn't do much for you. The fermented foods actually had a really amazing effect, they increased microbiome diversity and they also decreased over two dozen inflammatory markers that we were able to survey through these great technologies that give us comprehensive immune profiling. We really saw a signature of exactly what we'd want to see to counter the industrialized deterioration of the gut microbiome with the fermented food diet, increased microbiome diversity, decreased inflammation, and this was just over the course of a 6 to 10 week intervention. We're really curious to pursue these findings in more detail, and see if now we can go into diseases that are pro-inflammatory, and counter those diseases to actually treat them in some way with the fermented food diet.  If I were to tell people what to do to counter all the negative impact of industrialization on our microbiome, I would say consume some fermented foods every day, and then start to integrate dietary fiber. As you eat the fermented foods, you'll increase your microbiome diversity. And our hope is that will allow you to harness the benefit of the high fiber diet as your microbiome diversity increases. Bio Justin Sonnenburg is a professor of microbiology and immunology at Sanford University. His research focuses on the basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. He is the coauthor of The Good Gut: Taking Control of your Weight, Your mood, and Your Long-Term Health.  

Peter Turnbaugh is a professor at UCSF studying the human microbiome's effect on pharmacology and nutrition. In our conversation, we discuss his journey to become a scientist and help pioneer the microbiome field starting in graduate school. We talk about his research as a fellow at Harvard then professor at UCSF, and his lab's current work. A key theme across the conversation is learning by doing.Peter's work has been anchored around predicting and controlling the metabolism of complex microbial communities. Going to a liberal arts college, Whitman College, Peter gravitated more to science because the grades seemed more objective. An experience in a stem cell lab helped Peter learn that science is not just a series of facts and helped spark him to apply to a PhD program. He applied to a bunch of schools, getting rejected by many of them like UCSF, and got into 2 programs. Peter ultimately chose to attend WUSTL. This might have been one of the best, and luckiest, decisions Peter made. Washington University in St. Louis was an epicenter for the Human Genome Project and is a hotbed of genomics/bioinformatics talent. Going in his rotations, Peter was excited about genomics and wanted to work on more computational problems. He ended up joining Jeffrey Gordon's lab, a legend in genomics. Jeff gave Peter the nickname, “Professor,” almost foretelling his future. Ruth Ley had also just joined the lab as a postdoctoral fellow after working with Norman Pace and wanted to study microbes across mammals. She had gone to the St. Louis Zoo to collect samples. On Peter's first day in the lab, the fridge was full of wild animal poop to study. At the time metagenomics was not widely accepted - many genome scientists thought microbial communities would be impossible to understand. This is around 2004 and there wasn't a checklist to follow. Peter, Ruth, and the lab had to not be shy to ask for help in order to pioneer a new field of the human microbiome. This ultimately led to 2 papers in 2006 that established gut microbes associated with obesity.After writing up his thesis, Peter wanted to “keep going as far as he can go” with science. He became a Bauer Fellow at Harvard, rejected by UCSF again during this process, and was excited to start his own lab. Similar to his grad school research, Peter learned by doing to build a lab. The lab's initial idea was to switch from studying host-associated microbes' role in diet to pharmacology. Xenobiotics seemed “really weird” and an open field to study. A 2013 paper showed how diet can alter the human microbiome, where the lab had to run the trial themselves - feeding participants a veggie or meat-only diet over 5 days. This type of work helped Peter finally get into UCSF and become a professor.The next skill he had to learn while doing was grant writing. Up until then, Peter had only written grad school applications and a 3-page proposal to Harvard that gave him 5 years of guaranteed funding. At UCSF, he's built a highly successful group leading the way on the study of the human microbiome and how it intersects with diet & pharmacology. He's expanded to work on CRISPR/phage research now, and excited to see how that thread grows over the next few years. Looking back, Peter has gained a greater appreciation for the community, something his grad school mentor, Jeffrey Gordon had emphasized. Just as much as multiple genes affect something like height or a disease, it's important to go beyond a single microbe causing a phenotype.

As a child of the Space Age, Jeffrey Gordon dreamed of becoming an astronaut and discovering life on Mars. Instead he found fascinating life forms and interactions closer to home, inside the gastrointestinal tract.The microbiome researcher, winner of the 2023 Global Grants for Gut Health Research Group Prize, tells Julie Gould about his research focus and the workplace culture in his lab at Washington University School of Medicine in St Louis, Missouri.Gordon also describes the “magical meeting,” that forged a longstanding collaboration with physician Tahmeed Ahmed, executive director of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), and their investigations into how immaturity of the gut microbiota contributes to malnutrition.The two researchers explain how the prize money will help to further strengthen an ongoing two-way knowledge exchange between the US team and their colleagues in Dhaka.This episode of the podcast is sponsored by the Global Grants for Gut Health, supported by Yakult and Nature Portfolio. Learn more about the current call for grant applications and how to apply at this link. Hosted on Acast. See acast.com/privacy for more information.

Siete millones de años después de separarnos de un ancestro común, humanos y chimpancés compartimos el 90-95% del ADN. Un ambicioso proyecto internacional ha desarrollado el mayor catálogo de ADN de primates (la secuencia de más de 800 individuos pertenecientes a 233 especies, casi la mitad de las que existen en el planeta). El estudio, publicado en un especial de la revista Science, revela características fundamentales de la evolución humana y aporta claves para identificar las mutaciones que causan enfermedades como el cáncer y también para la conservación de la biodiversidad. Hemos entrevistado Tomàs Marquès-Bonet, investigador ICREA en el Instituto de Biología Evolutiva (centro mixto del CSIC y la Universidad Pompeu Fabra), catedrático de Genética de esta Universidad, y líder de este estudio. Hemos informado del Premio Princesa de Asturias de Investigación Científica y Técnica a los estadounidenses Jeffrey Gordon, Peter Greenberg y Bonnie Bassler por sus logros en la búsqueda de nuevos tratamientos efectivos contra bacterias resistentes a antibióticos. Y de la concesión de los Premios Jaume I a Antonio Echevarren Pablos (Investigación Básica); Guillermina López Bendito (Investigación Médica); Carlota Escutia Dotti (protección del medioambiente); Daniel Maspoch Comamala (Nuevas Tecnologías); y Olympia Bover Hidiroglu (Nuevas Tecnologías). Isabel Fernández nos ha contado la incorporación de España a la infraestructura europea OPERAS, un proyecto para promover el conocimiento en abierto sobre Humanidades y Ciencias Sociales. Con testimonios de Elea Giménez, investigadora del Centro de Ciencias Humanas y Sociales del CSIC y presidenta del Comité Científico de OPERAS. Montse Villar nos ha hablado de las corrientes intergalácticas que alimentan de gas a lejanas galaxias. Con Jesús Zamora hemos reflexionado sobre los temores que provoca la inteligencia artificial. Y hemos reseñado los libros “La armonía de las células. Una exploración de la medicina y del nuevo ser humano”, de Siddhartha Mukherjee (Debate); y “Expanding universe. The Hubble Space Telecope” (Taschen). Escuchar audio

Esta semana se ha hecho público el Premio Princesa de Asturias de Ciencia y Tecnología, y este humilde servidor vuestro ha estado entre el jurado :) El premio ha reconocido los trabajos de Jeffrey Gordon, Peter Greenberg y Bonnie Bassler que han contribuido a entender el papel de las comunidades de microorganismos en nuestro planeta, y en particular las comunidades que habitan a los seres humanos: nuestra microbiota. Antes de estos trabajos se tendía a pensar en los microorganismos como seres esencialmente solitarios, o sin las herramientas necesarias para relacionarse entre ellos y con ningún otro ser vivo. Gracias a los esfuerzos de los premiados ahora sabemos que seres tan sencillos como las bacterias pueden realizar formas sencillas de "comunicación", que les sirven para coordinarse cuando forman una comunidad o para relacionarse con sus hospedadores, cuando viven dentro de otro ser vivo. Esto también significa que existe cierta cooperación entre esos microorganismos y los seres vivos que los rodean, así que ahora los vemos como grupos mucho más dinámicos capaces de llevar a cabo acciones colectivas. Para ayudarnos a contar todo esto contamos hoy en la sección con la ayuda de Ginés Morata, que también formó parte del jurado y es investigador en el Centro de Biología Molecular Severo Ochoa en Madrid, además de galardonado con el Premio Príncipe de Asturias en el año 2007. En este episodio también podéis escuchar la sección de Santi García Cremades, en la que nos propone un reto matemático relacionado con el crecimiento de una colonia de bacterias. Al final del episodio podéis encontrar la solución ;) Si queréis aprender más sobre las extraordinarias capacidades de los microorganismos podéis escuchar los episodios s03e10 y s04e06 de Aparici en Órbita, en los que tratamos el tema. También podéis encontrar episodios relacionados en nuestro pódcast hermano, La Brújula de la Ciencia: buscad los capítulos s08e33, s09e39, s05e24, s05e28, s07e36 y s11e29. En La Brújula os hemos contado también la historia de las orugas capaces de comer plástico que mencionamos en este episodio; la tenéis en los capítulos s06e37 y s09e24. Este programa se emitió originalmente el 8 de junio de 2023. Podéis escuchar el resto de audios de Más de Uno en la app de Onda Cero y en su web, ondacero.es

Siete millones de años después de separarnos de un ancestro común, humanos y chimpancés compartimos el 90-95% del ADN. Un ambicioso proyecto internacional ha desarrollado el mayor catálogo de ADN de primates (la secuencia de más de 800 individuos pertenecientes a 233 especies, casi la mitad de las que existen en el planeta). El estudio, publicado en un especial de la revista Science, revela características fundamentales de la evolución humana y aporta claves para identificar las mutaciones que causan enfermedades como el cáncer y también para la conservación de la biodiversidad. Hemos entrevistado Tomàs Marquès-Bonet, investigador ICREA en el Instituto de Biología Evolutiva (centro mixto del CSIC y la Universidad Pompeu Fabra), catedrático de Genética de esta Universidad, y líder de este estudio. Hemos informado del Premio Princesa de Asturias de Investigación Científica y Técnica a los estadounidenses Jeffrey Gordon, Peter Greenberg y Bonnie Bassler por sus logros en la búsqueda de nuevos tratamientos efectivos contra bacterias resistentes a antibióticos. Y de la concesión de los Premios Jaume I a Antonio Echevarren Pablos (Investigación Básica); Guillermina López Bendito (Investigación Médica); Carlota Escutia Dotti (protección del medioambiente); Daniel Maspoch Comamala (Nuevas Tecnologías); y Olympia Bover Hidiroglu (Nuevas Tecnologías). Isabel Fernández nos ha contado la incorporación de España a la infraestructura europea OPERAS, un proyecto para promover el conocimiento en abierto sobre Humanidades y Ciencias Sociales. Con testimonios de Elea Giménez, investigadora del Centro de Ciencias Humanas y Sociales del CSIC y presidenta del Comité Científico de OPERAS. Montse Villar nos ha hablado de las corrientes intergalácticas que alimentan de gas a lejanas galaxias. Con Jesús Zamora hemos reflexionado sobre los temores que provoca la inteligencia artificial. Y hemos reseñado los libros “La armonía de las células. Una exploración de la medicina y del nuevo ser humano”, de Siddhartha Mukherjee (Debate); y “Expanding universe. The Hubble Space Telecope” (Taschen). Escuchar audio

Jeffrey Gordon is the Founder & CEO of Bayou Insurance Agency located in Monroe, Louisianna. Jeffrey Gordon started Bayou Insurance after working in the industry for 8 years. He was frustrated with the way agencies were run and how “clients” were just a number. Bayou Insurance was formed on the foundation of caring. Each staff member that has joined Bayou Insurance has the same belief. We value each and every partnership, and we accept the charge to be your trusted insurance advisor. We are here to partner with, and serve, those who truly care to protect what they have worked so hard to build. Make sure to connect with Jeffrey on social media! https://www.bayouagency.com/ To learn more about becoming a Freight Agent: https://spi3pl.com/ To learn more about Trucker Tools: www.truckertools.com Ditch your carrier packet, Drive more carrier sales and get better load coverage with seamless digital onboarding, TMS integration, and smart load coverage, visit: https://brokercarrier.com/

In Episode #191 I sit down with Stanford University Professor's Dr Christopher Gardner and Dr Justin Sonnenburg to talk about fermented foods, fibre, gut health and immunity. This conversation was organised following the results of their latest randomised controlled trial 'Gut-microbiota-targeted diets modulate human immune status' which was published in Cell Press in 2021. In this conversation we cover: Dr Sonnenburg's background and journey into studying the microbiome Defining the terms ‘microbiome' and ‘microbiota The development of technology in learning more about the microbiome What defines a healthy microbiome and dysbiosis Studying the microbiomes of traditional populations such as the Hadza tribe The benefits of microbiome diversity Lack of microbiome diversity Intestinal permeability How Justin and Christopher came to working together The mission behind their study of fibre and fermented foods The methodology of the study The definition of fermented foods Microbes being added to packaged fermented foods What the study found in terms of fermented food Conducting studies with humans vs animals What can the study tell us about the effectiveness of probiotics Sodium in fermented foods What the study found in terms of fibre intake Accuracy of stool/microbiome testing Key takeaways from the study and plenty more Justin Sonnenburg, PhD bio: Dr Sonnenburg is an associate professor in the Department of Microbiology and Immunology at the Stanford University School of Medicine, where he studies the gut microbiota in health and disease and co-directs the Center for Human Microbiome Studies. He and his wife Erica, are the authors of the book The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-Term Health. Their laboratory at Stanford develops and employs diverse technologies to understand basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. An ongoing objective of the research program is to devise and implement innovative strategies to prevent and treat disease in humans via the gut microbiota. Current pursuits include genetic engineering commensal bacteria to enable therapeutic delivery within the gut, as well as understanding the health impact of microbiome change that has occurred during industrialization. Justin conducted his Ph.D. in Biomedical Sciences at the University of California, San Diego in the laboratory of Ajit Varki. His postdoctoral work was conducted at Washington University in Saint Louis, Missouri in the laboratory of Jeffrey Gordon. He has received an NIH Director's New Innovator Award and Pioneer Award. He serves on several scientific advisory boards and is a co-founder of Novome Biotechnologies. Christopher Gardner, PhD bio: Dr Gardner is the Rehnborg Farquhar professor of medicine at Stanford, the director of Stanford Prevention Research Center's (SPRC) Nutrition Studies Group, and the director of the SPRC postdoctoral research fellow training program. His primary research focus for the past decade has been randomized controlled nutrition intervention trials (soy, garlic, antioxidants, ginkgo, omega-3 fats, vegetarian diets, weight loss diets), testing the effects of these on chronic disease risk factors that have included blood cholesterol, weight, inflammatory markers, and the microbiome. His research interests have recently shifted to two new areas. The first is to approach helping individuals make healthful improvements in diet through motivators beyond health, linking to ongoing social

In Episode #191 I sit down with Stanford University Professor's Dr Christopher Gardner and Dr Justin Sonnenburg to talk about fermented foods, fibre, gut health and immunity. This conversation was organised following the results of their latest randomised controlled trial 'Gut-microbiota-targeted diets modulate human immune status' which was published in Cell Press in 2021.In this conversation we cover:Dr Sonnenburg's background and journey into studying the microbiomeDefining the terms ‘microbiome' and ‘microbiotaThe development of technology in learning more about the microbiomeWhat defines a healthy microbiome and dysbiosisStudying the microbiomes of traditional populations such as the Hadza tribeThe benefits of microbiome diversityLack of microbiome diversityIntestinal permeabilityHow Justin and Christopher came to working togetherThe mission behind their study of fibre and fermented foodsThe methodology of the studyThe definition of fermented foodsMicrobes being added to packaged fermented foodsWhat the study found in terms of fermented foodConducting studies with humans vs animalsWhat can the study tell us about the effectiveness of probioticsSodium in fermented foodsWhat the study found in terms of fibre intakeAccuracy of stool/microbiome testingKey takeaways from the studyand plenty moreJustin Sonnenburg, PhD bio:Dr Sonnenburg is an associate professor in the Department of Microbiology and Immunology at the Stanford University School of Medicine, where he studies the gut microbiota in health and disease and co-directs the Center for Human Microbiome Studies. He and his wife Erica, are the authors of the book The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-Term Health. Their laboratory at Stanford develops and employs diverse technologies to understand basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. An ongoing objective of the research program is to devise and implement innovative strategies to prevent and treat disease in humans via the gut microbiota. Current pursuits include genetic engineering commensal bacteria to enable therapeutic delivery within the gut, as well as understanding the health impact of microbiome change that has occurred during industrialization. Justin conducted his Ph.D. in Biomedical Sciences at the University of California, San Diego in the laboratory of Ajit Varki. His postdoctoral work was conducted at Washington University in Saint Louis, Missouri in the laboratory of Jeffrey Gordon. He has received an NIH Director's New Innovator Award and Pioneer Award. He serves on several scientific advisory boards and is a co-founder of Novome Biotechnologies.Christopher Gardner, PhD bio:Dr Gardner is the Rehnborg Farquhar professor of medicine at Stanford, the director of Stanford Prevention Research Center's (SPRC) Nutrition Studies Group, and the director of the SPRC postdoctoral research fellow training program. His primary research focus for the past decade has been randomized controlled nutrition intervention trials (soy, garlic, antioxidants, ginkgo, omega-3 fats, vegetarian diets, weight loss diets), testing the effects of these on chronic disease risk factors that have included blood cholesterol, weight, inflammatory markers, and the microbiome. His research interests have recently shifted to two new areas. The first is to approach helping individuals make healthful improvements in diet through motivators beyond health, linking to ongoing social movements around animal rights and welfare, climate change, and social justice, and their relationships to food. The second is to focus less on trying to improve individual behaviors around food, and more on a food systems approach that addresses the quality of food provided by universities, worksites, hospitals, schools, etc., using a community-based participatory research approach and taking advantage of the many complementary disciplines represented on the Stanford campus, such as medicine, business, education, law, and earth sciences.Resources:The new study on fermented foods, fibre and the immune systemDr Gardner on TwitterThe Sonnenburg lab on TwitterSonnenburg Lab websiteThe Good Gut by Drs Justin & Erica SonnenburgPrevious episodes with Dr Christopher Gardner on plant-based meat and low versus high carb diets and weight loss.Want to support the show?If you are enjoying the Plant Proof podcast a great way to support the show is by leaving a review on the Apple podcast app. It only takes a few minutes and helps more people find the episodes.Simon Hill, Nutritionist, Sports PhysiotherapistCreator of Plantproof.com and host of the Plant Proof PodcastAuthor of The Proof is in the PlantsConnect with me on Instagram and TwitterDownload my two week meal plan

Jeffrey Gordon is the president of the American Birding Association, a position he has held since late 2010. Jeff is also a well-known writer, photographer, tour leader, and naturalist and a former Field Editor for Bird Watcher's Digest. He is a frequent speaker and field trip leader at various birding and nature festivals. Jeff recently joined Out There With The Birds host Wendy Clark in a conversation about transitions and trends in the American birding community, and how the American Birding Association is faring during the COVID-19 pandemic.

Savaged.us creator Jeffrey Gordon joined Ron on this week's PEGShow to cover the news and talk Dramatic Tasks. Check out Savaged.us! Get in on the new Deadlands Reloaded Servitor Plot Point Campaign PDF Bundle! And look into the Deadlands Classic Dime Novels Bundle, the Deadlands Classic Collectors PDF Bundle, and the FREE Deadlands Reloaded Helpin' Hands Bundle (which includes both Deadlands Reloaded core books) Watch the various Deadlands Live Streams Music: The Beach is No Place to Stare At Your Phone by Admiral Bob (c) copyright 2019 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/admiralbob77/60529

  Today, we’re talking to my friend, Lollie Weeks of Fast Brain Coaching. Lollie is a wife, mother and business owner with ADHD, parenting two boys with ADHD, and she’s driven to help students, families, and adults navigate the ADHD superhighway! In today’s episode, Lollie shares her experiences as kid, mom, and coach with ADHD.  We talk about empathic time travel, the power of fierce moms, why kids ruin sandboxes, the nature of ADHD coaching, and celebrating progress no matter how small. NOTE:  This episode may sound a little different to you. It was recorded live at the Commonwealth Learning Center in Needham, MA.  As a result, there are some audio artifacts and background noises that don’t typically appear on my episodes, but I think it feels a bit more intimate, too. I hope you enjoy listening to it as much as I enjoyed recording it!  Please let me know what you think about this experiment in live recording by emailing me at Brendan@ADHDessentials.com.Special Thanks to Jeffrey Gordon of Ideal Video Strategies for his support on this project!   Guest Links: Learn more about Lollie's ADHD Coaching work at https://fastbraincoaching.com. Check out Lollie's "Fortuitous Housewife" blog at https://fortuitoushousewife.com.   ADHD Essentials Links:   Contact Brendan about booking a workshop for your organization Join Our Facebook Community Learn about & Register for the The ADHD Essentials Online Parent Coaching Groups  Check out the ADHD Essentials Homepage Contact Brendan at brendan@ADHDessentials.com   ADHD Rewired Podcast Network Plugs: ADHD reWired Hacking Your ADHD ADHD Essentials  

Today, we’re talking to Gail Oakerman.  Gail is an Educational Consultant, Counselor, and one of my old College Professors.  She runs Five Points Counseling in Lunenburg, MA. In today’s episode, we discuss the internal struggle of ADHD, how systemic & cultural realities that get in our way, the power of teaching kids ways to talk about their challenges, and harnessing incremental change.   REGISTRATION IS OPEN: For the ADHD Essentials Online Parent Coaching Groups:CLICK HERE for more information, and to sign up!   SPECIAL ANNOUNCEMENT: My "Wall of Awful" model was recently featured on Jessica McCabe's How to ADHD channel on YouTube.  I'd love it if you'd take a look at her channel, as well as my episodes (Episode 1 and Episode 2).  They really do great work, and I'm honored to be included.   ADHD Essentials Links: Learn about & Register for The ADHD Essentials Online Parent Coaching Groups  ADHD Essentials Homepage Contact Brendan at brendan@ADHDessentials.com Join Our Facebook Community   Another big thank you to Jeffrey Gordon of Ideal Video Strategies, who did the heavy lifting on editing this episode.

En este episodio hablamos de los microorganismos que habitan nuestro cuerpo, con permiso o sin él: nuestra microbiota. Miles de millones de seres unicelulares viven en nuestra piel, nuestros ojos y, sobre todo, en nuestro intestino, y con la mayoría de ellos convivimos estupendamente. Más que eso: los necesitamos. Aprovechando que el profesor Jeffrey Gordon acaba de recibir el Premio Fronteras del Conocimiento en Biología y Biomedicina por demostrar la gran importancia que estos "polizontes" tienen para nuestra propia biología, os hablamos sobre algunos de los aspectos en que ellos influyen en nosotros y nosotros en ellos. Si os interesan los microorganismos y las cosas sorprendentes que son capaces de hacer echadles una oreja a los capítulos s05e24, s05e28, s06e40 y s08e22. Este programa se emitió originalmente el 17 de junio de 2019. Podéis escuchar el resto de podcasts de La Brújula en su canal de iVoox y en la web de Onda Cero, ondacero.es

Episode 61 - A Few Words with Jeffrey Gordon I met Jeffrey just a few months ago through a mutual friend of ours - thanks, Lysa - in Hudson, Massachusetts. We have done a little volunteering together for a local nonprofit organization and we both have "residencies" in our respective areas of expertise at a new co-working facility in Hudson called Out of Office.  During this conversation, I ask Jeff questions about his company, Ideal Video Strategies, how he helps his clients take their video production to the next level, personal branding, social media, marketing and more. Listen...  About Jeffrey Gordon Jeffrey Gordon had been working in the corporate world for over 10 years and was was looking for a more satisfying career. After lots of thought and discussion with his wife, Krista, Jeff decided to take the risk of starting his own company, Ideal Video Strategies. His desire to make a difference in people’s lives and be more active in his community has spearheaded this undertaking. Jeff has a Master’s Degree in Education Media Design from Full Sail University and a Bachelor’s Degree in Digital Recording Arts from New England Institute of Technology. He is a certified expert in Adobe Premiere Pro and has won multiple Telly Awards and AVA Digital Awards for his work. When not working, Jeff enjoys spending time with his wife and two young kids, Caitlyn and Alex. They keep him pretty busy! He also likes to spend time in his gardens, growing flowers and vegetables. He considers himself to have a very green thumb!

Today, we’re talking to Linda Katz or Right Fit College Coaching. Linda specializes in providing students with ADHD and similar learning disabilities with comprehensive college planning.  She helps them find the colleges that will best suit their interests and needs, and then helps them through the application process. In today’s episode, we talk about the college application process, how important it is for our kids to try out the career they’re looking at before committing four years of study to it,  how to find just such an internship in high school, and how college is different from high school.   Shameless Plugs:     Podcast Support: Today’s Episode was edited by Jeffrey Gordon of Ideal Video Strategies.  Go to www.idealvideostrategies.com to learn more about their work.   Guest Links: Learn more about Linda Katz and her work here.   ADHD Essentials Links: ADHD Essentials Homepage Contact Brendan at brendan@ADHDessentials.com Join Our Facebook Community Learn about & Register for The ADHD Essentials Online Parent Coaching Groups 

Lung cancer is caused by damaged cells in the lungs. Common culprits are cigarette smoke and radon gas. It is important for those at risk to be screened for lung cancer. Dr. Jeffrey Gordon, oncologist and hematologist, discusses lung cancer risk and screening procedure.

Dr. Alessi discusses hemochromatosis awareness with Ms. Patricia Moriarty and legislative initiatives with Dr. Jeffrey Gordon president of the Connecticut State Medical Society.

Meet Jeremy Bibaud, the gaming aficionado who co-hosts The Clickbait Podcast, and the enterprising writer behind a story-mapping project called YEG Storyhood. Jeremy is a guy who sees an opportunity and grabs it. He'd been writing for the online magazine PlayStation LifeStyle. When its previous podcast stopped, Jeremy and co-hosts Jeffrey Gordon and Brandon Hoover stepped in to make a podcast that, in part, addresses the community's reactions to stories. "Most people say, 'Don't read the comments,' but we read the comments," Jeremy says. "That's our job." And it is a paying gig, which is pretty cool. He's not getting rich, but podcasting doesn't cost him money, and he gets paid a bit for his time, too. You'll hear some sound advice in this episode on how to get into media about gaming. Jeremy is also a storyteller. You may have seen a story of his on your coffee sleeve as part of Jason Lee Norman's #yegwords project, and he has been published in various magazines. From that creative mind sprang the idea for YEG Storyhood, an effort to map Edmonton one story at a time. The way Jeremy sees it, there are people in all 286 of Edmonton's neighbourhoods, so there must be stories there, too, and he wants them. Learn more about what he's looking for in this episode, and hear his advice about breaking into fiction, too. This episode is also available in iTunes, on Google Play, on SoundCloud or on Stitcher. Jeremy recommended a couple of locally made podcasts with a global vision: The Expats: Adam Rozenhart's interview show with Canadians abroad. Jeremy shares a great story about the Portugal episode. Bollywood is for Lovers: Where Erin E. Fraser and Matt Bowes explore their passion for Hindi cinema. You can find Jeremy on Twitter: @misterbeebo. The Clickbait Podcast is on Twitter (@clickbaiters). YEG Storyhood is on Facebook, and give it a like on Make Something Edmonton, too. This is the last of the episodes I recorded at the Makerspace at the downtown Edmonton Public Library on 100 in 1 Day back in June.  P.S. The next Edmonton Podcasting Meetup is on Oct. 23 at Variant Edition. RSVP here. This episode of Seen and Heard in Edmonton is brought to you by Taproot Edmonton, a source of curiosity-driven stories about the city, cultivated by the community. We're gearing up to publish our next story later this month, so here's one more reminder to read our first one, a story about the deer off 23rd Avenue by Mel Priestley.  Satisfy your curiosity about the city by joining Taproot.

Bird Calls show with Jeffrey A. Gordon, American Birding Association president, as the guest. What does the ABA have in store for 2012? What advances did it make in 2011? How does one fashion a career in birding and become the president of a major birdwatching organization?

Like living things, legal theories are born, grow, change, and die. We are joined by Jeremy Kessler and David Pozen to discuss this life cycle and how it applies to some popular theories today, like originalism. We start by discussing what prescriptive legal theories are and how there was a move to transcend politics through process-based theories (3:23). Then: the theory of theories (9:31), the example of Brown v. Board, originalism, and brute political facts (20:17), a sociological story (25:10), the role of law schools and teaching in theory evolution (31:22), a discussion of trees, structure, and the role of higher order principles in law (37:50), theory change in private law (47:14), normative vs. descriptive theories of theories (54:05), and the internal and external approaches to originalism (1:04:27). This show’s links: Jeremy Kessler’s faculty profile and writing David Pozen’s faculty profile and writing Jeremy Kessler and David Pozen, Working Themselves Impure: A Life-Cycle Theory of Legal Theories Oral Argument 97: Bonus Lawrence Solum, Kessler and Pozen on the Development of Normative Legal Theories Lawrence Solum, Legal Theory Lexicon: It Takes a Theory to Beat a Theory Daniel Carpenter, The Forging of Bureaucratic Autonomy:Reputations, Networks, and Policy Innovation in Executive Agencies, 1862-1928 About Lévi-Strauss’s structuralism Javins v. First National Realty Corp. Jeffrey Gordon, The Empty Call for Benefit-Cost Analysis in Financial Regulation Guido Calabresi and Philip Bobbitt, Tragic Choices Open Science Collaboration, Estimating the Reproducibility of Psychological Science S.J. Gould and R.C. Lewontin, The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme Lawrence Solum, Legal Theory Lexicon: Originalism and Legal Theory Lexicon: The New Originalism (each containing links and citations to many of the key works) Stephen Smith, Saving Originalism from Originalists An example of Larry Solum’s April Fools jokes Special Guests: David Pozen and Jeremy Kessler.

Our guest is the founder of Writers Boot Camp, Jeffrey Gordon. Jeffrey Gordon. He'll share in depth information seldom heard on screenwriting.  Jeff  explains his unique screenwriting coursework, which includes more than 100 proprietary writing tools and exercises that represent a language for creative collaboration in the entertainment industry. Thirty Writers in the Boot Camp alumni have had movies made in the past 18 months alone. To learn more about Jeffrey visit his website at http://writersbootcamp.com/creative_team.asp To learn more about Carole Dean and From the Heart Productions visit http://fromtheheartproductions.com/

Our guest is the founder of Writers Boot Camp, Jeffrey Gordon. He will give us tips of screenwriting and explain his unique screenwriting coursework, including more than 100 proprietary writing tools and exercises that represent a language for creative collaboration in the entertainment industry.Thirty Writers in the Boot Camp alumni have had movies made in the past 18 months alone. To learn more about Jeffrey visit his website at http://writersbootcamp.com/creative_team.asp To learn more about Carole Dean and From the Heart Productions visit http://fromtheheartproductions.com/  

In the first show of 2007, Drs Chris, Dave and Helen find out why red wine is better for you than white wine or grape juice, and explore the science of healthy living with with London University researcher and author Roger Corder. We also discover the science behind another of the nations favourite drugs, caffeine, with the help of Bristol Universitys Peter Rogers, and University of St Louis researcher Jeffrey Gordon explains how the bugs living in your intestines help you to make the most out of mealtimes. They might also, he thinks, make some people fat. Plus, in kitchen science, Dave demonstrates the physics of how salt keeps roads frost-free.

In the first show of 2007, Drs Chris, Dave and Helen find out why red wine is better for you than white wine or grape juice, and explore the science of healthy living with with London University researcher and author Roger Corder. We also discover the science behind another of the nations favourite drugs, caffeine, with the help of Bristol Universitys Peter Rogers, and University of St Louis researcher Jeffrey Gordon explains how the bugs living in your intestines help you to make the most out of mealtimes. They might also, he thinks, make some people fat. Plus, in kitchen science, Dave... Like this podcast? Please help us by supporting the Naked Scientists

In the first show of 2007, Drs Chris, Dave and Helen find out why red wine is better for you than white wine or grape juice, and explore the science of healthy living with with London University researcher and author Roger Corder. We also discover the science behind another of the nations favourite drugs, caffeine, with the help of Bristol Universitys Peter Rogers, and University of St Louis researcher Jeffrey Gordon explains how the bugs living in your intestines help you to make the most out of mealtimes. They might also, he thinks, make some people fat. Plus, in kitchen science, Dave... Like this podcast? Please help us by supporting the Naked Scientists