Podcasts about reactive oxygen species ros

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

Morley Robbins, a “retired” Hospital executive (12 yrs) and healthcare consultant (20 yrs), chose to become a Wellness Coach in 2009. In the process, he has become a self-taught mineral expert. His highest purpose is to share this decade of daily scientific research on the profound metabolic interplay between 3 KEY minerals: Magnesium, Bioavailable Copper and Iron. These mineral-driven metabolic concepts are not fully understood, nor appreciated in practitioner circles, and are certainly not in the public's consciousness. He regularly confers with world-renowned mineral experts, in addition to his research, and focuses on continued research, writing and educational conferences to promote his insights and findingS. To that end, he manages two websites to provide mineral education: The MAG Facebook Group: http://gotmag.org and The Root Cause Protocol: http://therootcauseprotocol.com His priority focus is to master mineral metabolism and its foundational impact on our health. There is a REASON for that priority focus… Left unchecked, Copper-Iron Dysregulation builds in the body, generates an imbalance of Reactive Oxygen Species (ROS), and the resulting metabolic confusion fosters every conceivable condition, syndrome, malady or disease that is growing steadily in North America, as well as the Planet. He has devised a unique blood test to reveal these mineral dynamics, and regularly trains practitioners to use this diagnostic tool in their practices. He has now performed over 5,500 consultations with clients in 45 countries around the world, and has trained scores of professionals in these unique mineral dynamics & concepts through his Copernican Institute. He speaks regularly at Wellness Conferences in New York, NY, Chicago, IL and Los Angeles, CA and was a speaker at The Forum for Integrative Medicine this March, 2019 in Seattle, WA. He is also a regular guest on dozens of different health-oriented Podcasts and Radio Shows. Dr. Fredrickson Links Book-Magnesium Answers-Coming October 27th, 2023! Instagram: Dr.Robert Fredrickson Instagram Business: FredricksonHealthSolutions TikTok: FredricksonHealth Facebook: FredricksonHealthSolutions Social Media Stream Page-https://beacons.page/fredricksonhealth

Dr Glenn McConell chats with Dr Carlos Henríquez-Olguín from The University of Copenhagen, Denmark. Carlos is an up and coming rising star exercise metabolism researcher. He discusses the challenges of doing mechanistic exercise research in Chile and how he ended up moving to the University of Copenhagen. Language challenges etc. He has been doing really ground breaking research on reactive oxygen species (ROS) and contraction/exercise and already won awards for his research. Twitter: @MuscleBiology.0:00. Introduction/reason invited Carlos onto Inside exercise4:00. Challenges doing mechanistic exercise research in Chile etc9:37. Cell culture and mouse ROS experiments in Chile12:11. How got into reactive oxygen species research14:25. Muscle dystrophy, contraction and ROS16:09. Chronic versus acute increases in ROS16:49. How/why moved to the University of Copenhagen19:20. No success with initial research at the University of Copenhagen20:30. Made his own luck21:39. The need for patience from supervisor if facing challenges23:40. Language challenges when coming from Chile26:30. Giving better visibility to early career researchers31:04. Prizes he has won in both exercise and ROS34:08. Challenges publishing when from less scientifically recognized countries36:22. What are reactive oxygen species?37:50. Theory of ROS and aging38:30. ROS, antioxidants, oxidative stress, ROS signaling40:05. Muscle antioxidants, exercise and disease42:19. Where in muscle are ROS coming from during contraction?45:02. NOX2, RAC1, glucose uptake with contraction47:21. What's activating ROS production during contraction?48:11. Nitric oxide vs ROS vs both?50:15. Acute versus chronic increases in ROS53:16. Best exercise for increasing your antioxidant defenses?57:50. High ROS production from mitochondria in some diseases59:30. Can exercise improve these diseases by producing ROS?1:00:41. Compartmentalization of ROS production in muscle1:02:03. Should supplement with antioxidants?1:07:23. Increased mortality in people taking high levels of supplements1:06:32. Antioxidant supplements improve those with chronically high ROS?1:09:20. Mitochondria ROS and mitochondria specific antioxidants1:14:37. Exercise and antioxidant gene expression1:16:50. Mitochondria have antioxidant enzymes1:17:50. Carlos's methods to study ROS with contraction/insulin resistance1:23:20. Takeaway messages1:27:39. ROS and glucose uptake during exercise1:29:43. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice

Listen to Dr. Tom Roselle, DC discuss reactive oxygen species (ROS) as a mechanism of sugar-induced diseases including joint diseases, cancer, insulin resistance, diabetes mellitus, cardiovascular diseases, asthma, atherosclerosis, and aging. A high-sugar diet has been shown to increase the formation of ROS. Reactive oxygen species (ROS) are natural byproducts of cellular oxidative metabolism and play important roles in the modulation of cell survival, cell death, differentiation, cell signaling, and inflammation-related factor production. For this and more episodes of Ageless Health® with Dr. Tom Roselle, DC, please visit https://www.drtomroselle.com/ageless-health-podcast/

In today's interview we go deep into the topic of metabolism with Latt Mansor, Ph.D. We explore the principal hormones related to metabolism, the relationship between Alzheimer's and insulin resistance, and the mechanism and protocol of the ketogenic diet. You'll learn why ketones are the body's preferred fuel, and how you can supplement to enhance your performance and learning. In this episode we cover:0:10:23 – Definition of Metabolism0:11:21 – Metabolic Flexibility0:15:49 – Insulin0:21:09 – Glucose0:24:42 – Triglycerides0:28:07 – Mitochondria0:29:09 – Reactive Oxygen Species (ROS)0:31:37 – Low Glucose States0:36:33 – Lipolysis0:39:09 – Ketones0:51:17 – Longevity0:58:49 – Alzheimer's1:04:11 – Exogenous ketones1:09:56 – Ketone-IQLearn more about Commune and check out all our health, nutrition, and functional medicine courses free for 14 days at onecommune.com/trial This podcast is supported by:HVMNA clean energy boost without sugar or caffeine. One shot will help you feel clear, focused, and ready to take on the day. When you're low on fuel, Ketone-IQ™ is your secret weapon. 20% OFF HVMN promo code: COMMUNE https://hvmn.com/COMMUNEBiOptimizers Magnesium Breakthrough is the ultimate magnesium supplement that offers the full spectrum of all seven types of magnesium, specially formulated to reach every tissue in your body for maximum health benefits.This one-of-a-kind product is designed to reverse low levels of magnesium, which could be causing a multitude of health problems.This means that this supplement acts like a brake on your body's nervous system, helping to calm and soothe, promoting a better quality of life. Visit magbreakthrough.com/onecommune and get 10% off on Magnesium Breakthrough with code onecommuneBetterHelpBetterHelp offers convenient online therapy on your schedule. It's the same professionalservice you'd get from an in-person therapist, but with the option to communicate whenand how you want – by chat, phone, or video call. Start on your own journey of self-discovery, with BetterHelp. Visit BetterHelp.com/commune to get 20% off your first month of online therapy. Kyolic Prevention is the best way to protect your heart health. In addition to maintaining a healthy diet,exercise and good sleep patterns, you can include one of the best-researched natural herbal supplements to your routine, Kyolic Aged Garlic Extract. Request a sample at Kyolic.com/sample-request. Use promo code “Commune”.Thrive MarketJoin Thrive Market today and get a FREE $80 in free groceries when you go to thrivemarket.com/communeLivOn LabsDiscover why Jeff Krasno, Schuyler Grant, and people who know wellness areditching pills, powders, and gummies for this powerful, nutrient-packed goo. GET FREE SAMPLES WITH ANY PURCHASE livonlabs.com/commune

In today's interview we go deep into the topic of metabolism with Latt Mansor, Ph.D. We explore the principal hormones related to metabolism, the relationship between Alzheimer's and insulin resistance, and the mechanism and protocol of the ketogenic diet. You'll learn why ketones are the body's preferred fuel, and how you can supplement to enhance your performance and learning.  In this episode we cover: 0:10:23 – Definition of Metabolism 0:11:21 – Metabolic Flexibility 0:15:49 – Insulin 0:21:09 – Glucose 0:24:42 – Triglycerides 0:28:07 – Mitochondria 0:29:09 – Reactive Oxygen Species (ROS) 0:31:37 – Low Glucose States 0:36:33 – Lipolysis 0:39:09 – Ketones 0:51:17 – Longevity 0:58:49 – Alzheimer's 1:04:11 – Exogenous ketones 1:09:56 – Ketone-IQ Learn more about Commune and check out all our health, nutrition, and functional medicine courses free for 14 days at onecommune.com/trial  This podcast is supported by: HVMN A clean energy boost without sugar or caffeine. One shot will help you feel clear, focused, and ready to take on the day. When you're low on fuel, Ketone-IQ™ is your secret weapon. 20% OFF HVMN promo code: COMMUNE https://hvmn.com/COMMUNE BiOptimizers  Magnesium Breakthrough is the ultimate magnesium supplement that offers the full spectrum of all seven types of magnesium, specially formulated to reach every tissue in your body for maximum health benefits.This one-of-a-kind product is designed to reverse low levels of magnesium, which could be causing a multitude of health problems.This means that this supplement acts like a brake on your body's nervous system, helping to calm and soothe, promoting a better quality of life. Visit magbreakthrough.com/onecommune and get 10% off on Magnesium Breakthrough with code onecommune BetterHelp BetterHelp offers convenient online therapy on your schedule. It's the same professional service you'd get from an in-person therapist, but with the option to communicate when and how you want – by chat, phone, or video call. Start on your own journey of self-discovery, with BetterHelp. Visit BetterHelp.com/commune to get 20% off your first month of online therapy.  Kyolic  Prevention is the best way to protect your heart health. In addition to maintaining a healthy diet,exercise and good sleep patterns, you can include one of the best-researched natural herbal supplements to your routine, Kyolic Aged Garlic Extract. Request a sample at Kyolic.com/sample-request. Use promo code “Commune”. Thrive Market Join Thrive Market today and get a FREE $80 in free groceries when you go to thrivemarket.com/commune LivOn Labs Discover why Jeff Krasno, Schuyler Grant, and people who know wellness are ditching pills, powders, and gummies for this powerful, nutrient-packed goo. GET FREE SAMPLES WITH ANY PURCHASE  livonlabs.com/commune 

Huberman Lab Podcast Notes Key Takeaways A rough estimate of hydration needs at rest: consume 8oz of fluid for every hour you are awake for the first 10 hours of your day – this can be consumed as total volume over the course of the dayFollow Galpin's equation for hydration during exercise: your body weight (in pounds) / 30 = # of ounces to consume every 15 minutesDeliberate cold exposure sample protocol:2 minutes of deliberate cold exposure/water immersion up to the neck + 30 seconds of deliberate cold exposure with cold shower 5x per week Potential benefits: increase in catecholamines (benefits mood and well-being), sexual satisfaction (probably from increases in testosterone in men and women), reduction in anxiety, reduction in waist circumference in men, reduction in abdominal fat in menTo reduce nighttime urination frequency: (1) hydrate sufficiently during the day; (2) reduce fluid intake at night; (3)don't chug water at night if you drink! sip slowly, rate mattersKnow how much fluoride is in your tap water! Google your zip code + water analysis – (high fluoride even at 0.5mg/mL can negatively impact thyroid stimulating hormone)You don't need to enrich your water but if pH is insufficient or magnesium is low, address it to achieve better and more efficient hydration, reduce inflammation, blood pressure, and other health metrics Find out the profile of your tape water by googling your zip code + water analysisYou can purchase hydrogen molecular tablets to drop in water which will increase pHRead the full notes @ podcastnotes.orgIn this episode, I discuss our body's most vital and essential nutrient—water. I explain the structure of water and how it is used by the cells and tissues of our body, how much water we each need to drink and when in order to optimize our mental focus and physical performance; and I include how exercise, humidity, heat, and caffeine affect our hydration needs. I explain how temperature and pH influence water's physical properties and if there is any scientific basis for drinking so-called “pH water” or “alkalized water” to improve health. I explain how to test your tap water for contaminants (e.g., endocrine disruptors) and the documented problems with fluoride in drinking water. I provide options for filtering drinking water and describe different water types (e.g., reverse osmosis, hydrogen-enriched, electrolyzed reduced, deuterium depleted, etc.). Since the human body is mostly water (55-80% depending on one's age) and water has essential roles in health, disease and cellular function, everyone ought to benefit from understanding how best to clean our tap water, hydrate effectively and in some cases, adjust the type of water we drink to allow our brain and body to function optimally in regard to health and performance. For recommended water filters, tests and the full show notes, please visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Thesis: https://takethesis.com/huberman HVMN: https://hvmn.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Water (00:03:33) Tool Deliberate Cold Exposure, Immersion & Showers Mood & Fat Loss (00:15:26) Sponsors: LMNT, Thesis, HVMN, Momentous (00:19:27) Water: Physical Properties & Chemistry (00:26:32) Bonds & Water Phases, “Structured Water” (00:34:07) Body, Cells & Water (00:36:22) AG1 (Athletic Greens) (00:37:37) Water as a Solvent, Temperature & pH (00:41:49) Water Transport in Cells, Aquaporin Channels (00:49:46) Alkaline/pH Water; Temperature, pH & Water Transport (00:55:14) Water Cellular Function, Reactive Oxygen Species (ROS) & Antioxidants (01:01:20) Sponsor: InsideTracker (01:02:38) Tool: Baseline Hydration (01:11:35) Tool: Hydration & Exercise, Galpin Equation (01:15:40) Tool: Hydration, Sauna, Humidity & Sweat; Thirst, Caffeine (01:19:15) Hydration; Cognitive & Physical Performance  (01:23:53) Tool: Water Filtration; Nighttime Urination (01:29:35) Tap Water Tests, Disinfection Byproducts (DBPs), Fluoride & Thyroid Health (01:37:18) Tool: Water Filters (01:44:18) Tool: Resting Tap Water & Sediment (01:48:13) Tool: “Hard Water”; Magnesium, Calcium & Cardiovascular Health (01:53:40) Water Temperature (01:56:42) Water Types: Distilled, Reverse Osmosis, Hydrogen-Enriched (02:03:26) Hydrogen-Enriched Water, Magnesium, Optimize Hydration (02:11:13) Tool: Molecular Hydrogen Tablets, Water pH (02:14:05) Structured Water (02:16:39) Tool: Water Pipes, Faucet Filter (02:19:42) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I discuss our body's most vital and essential nutrient—water. I explain the structure of water and how it is used by the cells and tissues of our body, how much water we each need to drink and when in order to optimize our mental focus and physical performance; and I include how exercise, humidity, heat, and caffeine affect our hydration needs. I explain how temperature and pH influence water's physical properties and if there is any scientific basis for drinking so-called “pH water” or “alkalized water” to improve health. I explain how to test your tap water for contaminants (e.g., endocrine disruptors) and the documented problems with fluoride in drinking water. I provide options for filtering drinking water and describe different water types (e.g., reverse osmosis, hydrogen-enriched, electrolyzed reduced, deuterium depleted, etc.). Since the human body is mostly water (55-80% depending on one's age) and water has essential roles in health, disease and cellular function, everyone ought to benefit from understanding how best to clean our tap water, hydrate effectively and in some cases, adjust the type of water we drink to allow our brain and body to function optimally in regard to health and performance. For recommended water filters, tests and the full show notes, please visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Thesis: https://takethesis.com/huberman HVMN: https://hvmn.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Water (00:03:33) Tool Deliberate Cold Exposure, Immersion & Showers Mood & Fat Loss (00:15:26) Sponsors: LMNT, Thesis, HVMN, Momentous (00:19:27) Water: Physical Properties & Chemistry (00:26:32) Bonds & Water Phases, “Structured Water” (00:34:07) Body, Cells & Water (00:36:22) AG1 (Athletic Greens) (00:37:37) Water as a Solvent, Temperature & pH (00:41:49) Water Transport in Cells, Aquaporin Channels (00:49:46) Alkaline/pH Water; Temperature, pH & Water Transport (00:55:14) Water Cellular Function, Reactive Oxygen Species (ROS) & Antioxidants (01:01:20) Sponsor: InsideTracker (01:02:38) Tool: Baseline Hydration (01:11:35) Tool: Hydration & Exercise, Galpin Equation (01:15:40) Tool: Hydration, Sauna, Humidity & Sweat; Thirst, Caffeine (01:19:15) Hydration; Cognitive & Physical Performance  (01:23:53) Tool: Water Filtration; Nighttime Urination (01:29:35) Tap Water Tests, Disinfection Byproducts (DBPs), Fluoride & Thyroid Health (01:37:18) Tool: Water Filters (01:44:18) Tool: Resting Tap Water & Sediment (01:48:13) Tool: “Hard Water”; Magnesium, Calcium & Cardiovascular Health (01:53:40) Water Temperature (01:56:42) Water Types: Distilled, Reverse Osmosis, Hydrogen-Enriched (02:03:26) Hydrogen-Enriched Water, Magnesium, Optimize Hydration (02:11:13) Tool: Molecular Hydrogen Tablets, Water pH (02:14:05) Structured Water (02:16:39) Tool: Water Pipes, Faucet Filter (02:19:42) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Today we take a different look at Parasomnia's and discuss deaths related to sleep disorders; from a Sleepwalking insanity defense, Reactive Oxygen Species(ROS) build up from Insomnia, and mysterious death of a Utah woman who was described as a sleepwalker.

Eating for Hill Drills Hill drills are an important part of many runners regular training routines and can help a runner become faster, fitter, stronger.  BUT, hill running, especially downhill running, is known to cause microtears of muscle tissue.  These microtears are important for triggering muscle remodelling and adaptation, however if they become severe or chronic due to poor nutrition and insufficient recovery from training, they may negatively affect running performance.  So, we are going to: Give an overview of how hill drills affect muscle - both positively AND negatively.  Outline some nutritional factors to help prevent or limit muscle damage from hill drills Give some ideas of how to put the nutrition recommendations into practice   https://sunny-trailblazer-4067.ck.page/cebc1ad414 (BOOK YOUR PLACE) on our next FREE TRAINING: Learn all about our Healthy Woman Healthy Runner Method. We love podcasting but we love being with you LIVE even more so we can't wait to meet you in our ZOOM ROOM!https://sunny-trailblazer-4067.ck.page/cebc1ad414 (BOOK HERE!) (04:20) What effect do Hill Drills have on muscle? Hill Drills are used as part of a runners training plan to help them become fitter, faster, stronger in the long-term. This is because they help enhance the physiological and metabolic adaptations of exercise as well as support: Leg muscle strength Stride speed Improvement of VO2 Max and HR Enhanced running economy Protection from DOMS …and so much more…so really beneficial in the long-term for most runners. In fact it is thought that as little as six weeks of hill drills (being undertaken once a week) could induce some of these benefits.  BUT….. Hill Drills do carry some risk of exercise induced muscle damage (EIMD), especially downhill running as it causes eccentric muscle contraction.  So, what is eccentric muscle contraction? It is when the muscle is lengthening during the contraction: at this time the force applied to the muscle exceeds the force produced by the muscle itself, in that moment. This is known as mechanical stress and is known to cause breaking of the components of the muscle tissue that are required for the contraction (otherwise known as microtears). These microtears are necessary for muscle adaptation and muscle remodelling and rebuilding, BUT if the tears are severe, or become chronic, running performance could begin to suffer.  The fallout from these chronic or severe tears is inflammation. Any injury will lead to an inflammatory response in the body and this inflammatory response is known to be associated with: Pain Decreased ability to generate muscle strength Decreased range of motion Localised swelling Delated onset muscle soreness (DOMS) Increased muscle protein markers in blood e.g. creatine-kinase (CK) and Myoglobin (Mb)   Increase of general inflammatory markers in blood e.g. C-Reactive Protein (CRP), tumor-necrosis factor (TNF-a), Nuclear Factor Kappa B (NF-kB) Production of Reactive Oxygen Species (ROS) – known to damage cells ….this will ultimately result in compromised running performance. (12:10) Which nutrients could help prevent or limit muscle damage from hill drills? There are many nutrients that could help support a runner following injury and inflammation, however there are three that have been researched for their benefits in supporting an individual performing eccentric muscle contraction (such as downhill running). These three nutrients are: Protein Curcumin Quercetin PROTEIN: Protein provides the building blocks in the form of amino acids to repair and rebuild muscle following any type of muscle damage or injury. BUT it is the branched chain amino acids (BCAAs) i.e. leucine, isoleucine and valine that are especially important because they are the most efficient at triggering the muscle protein synthesis (MPS) cascade with leucine being the master trigger of the rebuilding...

In this podcast, Dr. Berg talks about ROS, which stands for Reactive Oxygen Species. It can either be free radical (unpaired electrons) or non-free radical involving oxygen. The body makes ROS and it can also be generated from the environment as well. The reason why the body makes ROS is that there is a natural process or a natural programmed cell death in the body called Apoptosis, a condition where the body is killing off certain cells that is essential for life. ROS has the ability to eliminate certain things that you don't want in the body. Ketones reduces excess ROS in the body and it can act as an antioxidant to protect the nerves. • Take Dr. Berg's Free Keto Mini-Course! • How to Bulletproof your Immune System Course • Dr. Berg's Beginner Guide to Healthy Keto & Intermittent Fasting Plan • Intermittent Fasting Basics for Beginners • Dr. Berg's Healthy Ketogenic Diet Basics: Step 1: https://youtu.be/vMZfyEy_jpI Step 2: https://youtu.be/mBqpaAKtnXE Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Peter Dobromylskyj is a UK-based veterinary anaesthetist and nutrition blogger whose blog Hyperlipid is amongst the longest-running and most highly respected in the low-carb and ancestral health communities. Peter has been writing about the biochemistry of nutrition since 2006, and has authored over 800 posts aimed at reviewing, analysing, and interpreting nutrition literature. Given his outside-the-box thinking and unconventional approach to metabolism and health, Peter's work has amassed a large and devoted following. Today, NBT Scientific Director Megan Hall interviews Peter to talk about insulin resistance, including the factors that cause it and why the condition is actually physiologically adaptive. Peter compares dietary saturated fats to polyunsaturated fatty acids (PUFAs), and explains why the scientific literature can be misleading when determining which truly promotes health. He gives specific science-based recommendations for how much PUFA to include in your diet, and also offers advice on what to feed your pets. For additional resources on insulin resistance and the influence of dietary fat sources, be sure to see the outline Megan wrote to prepare for this podcast. Here's the outline of this interview with Peter Dobromylskyj: [00:01:52] Insulin resistance is physiologically adaptive. [00:02:23] Reactive Oxygen Species (ROS) as signaling molecules. [00:04:52] Dr. David Speijer, Researcher at the University of Amsterdam. [00:05:31] Dr. Nick Lane, Professor of Evolutionary Biochemistry. [00:11:29] Protons thread on the Hyperlipid blog. [00:22:58] When insulin sensitivity becomes insulin resistance. [00:30:37] How long it takes to become insulin resistant. [00:34:55] Acipimox reduces free fatty acid circulation and temporarily reverses insulin resistance; 1. Santomauro, A. T., et al. "Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects." Diabetes 48.9 (1999): 1836-1841; 2. Aday, Aaron W., et al. "Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial." Obesity 27.11 (2019): 1812-1819. [00:36:19] Effects of caffeine on insulin resistance. [00:37:34] Phil Maffetone. [00:38:25] In mice, stearic acid reduces visceral adipose tissue; Study: Shen, Ming-Che, et al. "Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice." PLoS one 9.9 (2014): e104083. [00:38:34] Overfeeding studies in humans: 1. Rosqvist, Fredrik, et al. "Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans." Diabetes 63.7 (2014): 2356-2368; 2. Iggman, David, et al. "Association of adipose tissue fatty acids with cardiovascular and all-cause mortality in elderly men." JAMA cardiology 1.7 (2016): 745-753. [00:44:10] Raphael Sirtoli's Podcast: Carnivore Cast. [00:45:02] Butter fat → higher postprandial levels of FFAs and triglycerides; Study: López, Sergio, et al. "Distinctive postprandial modulation of β cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids." The American journal of clinical nutrition 88.3 (2008): 638-644. [00:46:50] Tucker Goodrich. [00:47:38] How much polyunsaturated fat is needed to cause metabolic dysfunction? [00:48:27] Leptin-deficient mouse study: Reeves, Valerie Lynn. "A diet enriched in stearic acid protects against the progression of type 2 diabetes in leptin receptor deficient mice (DB/DB)." (2012). [00:49:57] Aim for 2-4% of calories from linoleic acid (over 8% is obesogenic). [00:51:26] Efforts to lose weight with unsaturated vs. saturated fat stores. [00:53:29] Animal based keto with 15% polyunsaturates; Study: Hall, Kevin D., et al. "Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake." Nature Medicine 27.2 (2021): 344-353. [00:58:46] Electron transport chain (see this figure) and mitochondria. [00:58:57] Summary so far. [01:01:33] What dogs/pets should be eating. [01:09:05] Labradors may have problems with leptin signaling; Book: Raw Meaty Bones Promote Health, by Tom Lonsdale.

bengreenfieldfitness.com/croissantdiet       My friend Ron Penna recently emailed me about a guy named Brad Marshall who...         "...has a fascinating take on why we get fat called the ROS (Reactive Oxygen Species) Theory of Obesity and how ROS signaling as a result of eating saturated fats is critical for satiety. Provocative stuff and the more I read the more I’m pretty sure he is onto something. Joel Greene thinks Brad is crazy on this point but I have a feeling he will end up being right on most if not all of it. You can read more here: "         Essentially, our entire meat supply (pork and chicken especially) is much higher in polyunsaturated fats than they should be and the only real way to change it is to change what we feed them. .  He also has been working on . It has to be wrong but he makes VERY interesting arguments about it."         Naturally, I just had to get this guy on the show. Brad Marshall is the author of the Blog and the creator of .  Mildly obsessed with food and its history, his work focuses on trying to place current ideas about diet, including keto and carnivore diets into the framework of traditional Dietary patterns.  For instance, the French diet before 1970 combined flour, sugar, butter and wine and the population was lean.         Brad wrote which posits that ROS generation in the mitochondria of fat cells could provide the mechanism that explains why a traditional chinese peasant diet - low fat with 85% of calories from starch; a French diet combining butter, wine and flour and a modern keto diet could all be expected to produce leanness but combining flour with polyunsaturated fats is a recipe for obesity.  The core idea comes from the Protons thread of Peter Dobromylskyj’s blog .  Brad tested this hypothesis with his dietary experiment The Croissant Diet.         Brad is also the founder of , which is dedicated to producing pork and poultry products that are low in Linoleic acid, the n6 polyunsaturated fat (PUFA) whose intake has seen a dramatic worldwide increase in the last century.  Animals cannot make PUFA and so we can create pork and chicken that is nearly free of them.  You are what your animals eat.       Brad has a genetics degree from Cornell, a certificate from The French Culinary Institute, has studied cancer at Memorial Sloan-Kettering Cancer center and worked as a programmer for the Berkeley Drosophila Genome Project.  He spent the last 15 years raising rotationally grazed pastured pork on his farm in upstate New York while running a butcher shop, local food restaurant and USDA inspected meat processing facility. During our discussion, you'll discover: - Brad's background in molecular biology and cooking...8:00           - The production Reactive Oxygen Species (ROS) – and the ROS theory of obesity...18:43           - Unsaturated fats vs saturated fats in connection to ROS production and satiety...34:25         -What does all of this have to do with croissants?...44:45           -The Croissant Diet – getting specific...58:25           - Should we worry about endotoxemia with a diet high in saturated fats?...1:03:45           -The Wine Diet...1:09:30   bengreenfieldfitness.com/croissantdiet

استمعوا للبودكاست الخاص بي " الاحياء الدقيقة في دقيقة" ارجو ان ينال اعجابكم . ادعموني على منصة patreon من خلال مساهماتكم على الرابط التالي www.patreon.com/microinmin #podcast #microbiology_in_aminute شرح ال Pathogenesis of 2019_nCoV : ١_ بعد دخول الفايروس الى الجسم، يحتاج الى مستقبل خاص (receptors) ليساعده على دخول الخلية، هذا ال receptor يسمى Angiotensin Converting Enzymes_2 إنزيمات الأنجيوتنسين المحولة يرمز له ب ACE_2 . ٢_ ال ACE_2 موجود على سطح خلايا الحويصلة الهوائية "alveolar cells" الموجودة في الرئة . لدينا ٣ أنواع من alveolar cells : _النوع الأول "type1" : يكون مسؤول عن تبادل الغازات مع الأوعية الدموية (gas exchange ). _النوع الثاني "type2" : يكون مسؤول عن إنتاج مادة ال "surfactant" و هو عبارة عن مزيج من البروتينات و الدهون التي تقلل الشد السطحي للحويصلة الهوائية. _النوع الثالث"type3" : خلايا مناعية "dust cell" و هي عبارة عن macrophages .البلاعم *ال ACE_2 موجود على النوع الثاني"type2" من هذه الخلايا. ٣_ غلاف فايروس كورونا يحتوي على بروتينات تسمى spikes.المسامير و خاصة (S_Spike) تساعد الفايروس على الارتباط ب ACE_2 . عندما يحدث الارتباط اعلاه، تدخل المادة الوراثية للفايروس الى داخل الخلية و تسخر الخلية لإنتاج بروتينات الفايروس و بالتالي يتكاثر الفايروس و تموت الخلية. ٤_ عندما تموت type 2 alveolar cells ف أنها تقوم ب طرح مواد تسمى specific inflammatory mediators وسطاء التهابات محددة هذه المواد تعمل على تحفيز الخلايا المناعية الموجودة "macrophages" و عندما تتحفز ال macrophages" ف أنها تفرز ٣ مواد مناعية تسمى ب " cytokines"السيتوكينات و هي: Interleukin_1 "IL_1"إنترلوكين Interleukin_6 "IL_6" Tumor Necrosis Factor "TNF_α" .عامل نخر الورم هذه المواد الثلاث عندما تصل الى مجرى الدم فإنها تسبب الاعراض المصاحبة للاصابة ب فايروس كورونا. #الأعراض: اولاً _ على مستوى ال lungs:الرئتين ١_ هذه المواد تسبب توسع بالاوعية الدموية المحيطة بالحويصلة و كذلك زيادة نفاذية جدار هذه الأوعية _ Vasodilation توسع الأوعية _ Capillary permeability increased .زيادة النفاذية الشعرية و بالتالي يؤدي الى "alveolar edema".الوذمة السنخية. التي تؤدي الى نقص الأوكسجين "Hypoxia"نقص الأكسجة و ضيق التنفس. ٢_ فقدان ال surfactant يؤدي الى زيادة الشد السطحي ل الحويصلة و بالتالي يؤدي إلى Alveolar collapse .انهيار سنخي. و تؤدي أيضاً الى Hypoxia و ضيق التنفس. ٣_ كذلك هذه المواد الثلاث تؤدي الى زيادة تدفق خلايا "neutrophils" الى مكان الإصابة الفايروسية ك استجابة مناعية، خلايا neutrophils تقوم بقتل بعض الفايروسات عن طريق إفراز مادتين مثل : _Reactive Oxygen Species "ROS". _ أنواع الأكسجين التفاعلية "ROS" _Proteases. البروتياز لكن المادتين أعلاه أيضاً تقوم ب تحطيم بعض ال alveolar cells المسؤولة عن التبادل الغازي وتسبب حالة تسمى consolidation الدمج. التي تسبب أعراض السعال "cough" . ثانياً: على مستوى ال CNS : الجهاز العصبي المركزي المواد الثلاث "IL_1, IL_6, TNF" تذهب الى ال "hypothalamus".الغدة النخامية. و بالتالي تعمل على زيادة درجة حرارة الجسم و تسبب أعراض ال "Fever" .الحمى ثالثاً: في حالة severe. شديدة. ستحدث ال " SIRS " Systemic inflammatory response syndrome . متلازمة الاستجابة الالتهابية الجهازية. التي تؤدي الى septic shock . الصدمة الإنتانية و كذلك "MODS" Multiple organ dysfunction syndrome. متلازمة ضعف الأعضاء المتعددة. و خاصة الكلية و بالتالي يحصل فشل كلوي.

Dr Stephen Hussey has dedicated his medical career and research to understanding the heart and is here to set the record straight on saturated fat consumption and the real root cause of heart disease. We discuss how the heart and many of our organs are more fuel efficient on ketones as we generate more ATP, generate less oxidative stress and less free radicals or Reactive Oxygen Species (ROS). This episode is all about how being fat adapted, having lowered internal oxidative stress from burning both fat and carbs instead of just sugar predominantly for fuel, and utilizing techniques to lower stress in our lifestyles are a "killer" combination for lowering mortality risk from heart attacks and strokes. Amazing compelling episode to share with anyone who might benefit from learning how keto and low carb lifestyles support healthy hearts and optimal cardiovascular health!  Dr. Stephen Hussey MS, DC is a Chiropractor and Functional Medicine practitioner. He attained both his Doctorate of Chiropractic and Masters in Human Nutrition and Functional Medicine from the University of Western States in Portland, OR. He is the author of two books on health; The Health Evolution: Why Understanding Evolution is the Key to Vibrant Health and The Heart: Our Most Medically Misunderstood Organ. Dr. Hussey guides online coaching clients from around the world back to health by using the latest research and health attaining strategies. He focuses on helping people with heart disease and autoimmune disease achieve higher levels of health. In his down time he likes to be outdoors, playing sports, reading, writing, and spending time with his wife and their pets Dr. Stephen Hussey MS, DC, Co-Owner/Health Coach www.resourceyourhealth.com stephen@resourceyourhealth.com   Get Your Free e-Book on starting keto: https://www.ketogenicgirl.com/pages/free-ebook   Try the 28 Day Ketogenic Girl Challenge: https://www.ketogenicgirl.com Follow @ketogenicgirl on instagram for the latest posts and show updates. Special thank you to Fast Keto sponsor Butcher Box. New members receive 2 lbs of ground beef + 2 packs of bacon for free plus $20 off their first box by going to butcherbox.com/fastketo or enter promo code "FASTKETO" at checkout. Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet]. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

In this very information-loaded podcast, we talk about many topics pertaining to biochemistry, autophagy, mTOR, Immunometabolism, protein structures, the impact of aging in muscle protein synthesis and the important role of protein in living organisms.  BIO: Lucas Tafur is currently working as a postdoc studying the regulation of TOR complexes in yeast. He is onterested in a wide range of topics related to human health and metabolism, and lately mostly towards skeletal muscle. He is trying to understand physiology using a bottom-up approach, starting from the molecular basis and building up to the organismal level, considering an evolutionary background for interpretation. He currently writes articles in his personal blog www.p70s6k.com and in Nutmol, a spanish website on nutrition and metabolism with a molecular biology-centric perspective (www.nutmol.com). TIME STAMPS: 0:15 – Ketogeek Introduction, Energy Pods, and updates 10:28 – Lucas Tafur Introduction and a bottom-up approach towards nutrition 16:16 – What kind of studies are you interested in? 18:21 – How do you translate vitro studies into animal and human models? 21:50 – How substantial is autophagy when it comes to practical benefits? 27:57 – How does protein from food convert to muscles? 31:28 – What is mTOR and how does it impact muscle protein synthesis and cell growth? 39:10 – What is the role of mTOR and different muscular composition in bodybuilders, endurance athletes, and sedentary individuals? 42:13 – Is muscle hypertrophy triggered by muscular damage? 44:21 – How do age impact muscle mass and synthesis? 47:21 – Impact of anti-inflammatory drugs and muscle growth 49:30 – What is “inflammation” and immunometabolism? 53:50 – What is protein structure pertaining to structural biology? 57:57 – Can you tell what protein you will find in what organism? 1:00:14 – Why do we even have protein in nature and organisms? 1:03:50 – Why do animals have essential amino acids and plants don’t? 1:06:40 – Why ketosis may be less stressful when producing energy for the body 1:13:51 – Is there an advantage to having high Reactive Oxygen Species(ROS)? 1:15:30 – What is “nutmol”? 1:26:10 – What else do you do outside of research? 1:27:35 – What kind of research would you do for a billion dollars? 1:29:45 – Final Plugs GUEST LINKS: Personal Website: www.p70s6k.com  Spanish Website on Nutrition & Metabolism: www.nutmol.com Twitter: https://twitter.com/p70S6K KETOGEEK LINKS: Shop Energy Pods Amazon: https://www.amazon.com/Ketogeek-Chocolate-Energy-Organic-Vanilla/dp/B07B88S36J Ketogeek Ghee on Amazon: https://www.amazon.com/dp/B07B29HM3D Ketogeek Merchandise, Ghee & Energy Pods: https://ketogeek.com/collections Ketogeek Newsletter: https://ketogeek.com/pages/sign-up Shop Energy Pods: https://ketogeek.com/collections/energy-pods Wholesale: https://ketogeek.com/pages/wholesale

Dr. Thomas Seyfried is  a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine. I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You’ll notice we did this podcast shortly after the Super Bowl. In case people aren’t familiar with American football the New England Patriots had just beaten the LA Rams. I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It’s very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He’s really doing legendary work. So without further ado, here’s professor Seyfried. You can still preorder a copy of Food Lies on Indiegogo even though our campaign just ended. We still need your support to finish post production. http://indiegogo.com/projects/food-lies-post Support me on Patreon! http://patreon.com/peakhuman    Show Notes  Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is The mitochondria in your cells make energy (ATP) There’s 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air Cancer cells ferment - therefore they don’t use oxygen Not all cancer cells have genetic mutations, but all cancer cells ferment The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism On the other hand, normal cells use oxygen and very little amounts of glucose This should make sense to a lot of people because they’ve probably heard cancer cells need a lot of glucose and if you starve them of that they die Have to re-emphasize the fact that the DNA damage comes as a downstream effect Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body) The oxidative stress also causes damage to the nucleus and the genome The field of cancer research studies effects instead of causes We’re not treating cancer by looking at the root cause - it’s absurd - how would we ever cure it? This is supported by thousands of experiments and studies Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy Cancer cells can't use ketones There’s no dietary way to restrict glutamine to the cancer cells so drugs have to be used Basically nobody he’s heard of is treating it this way If it’s so clear this is how cancer works, why has this not reached the mainstream? The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic Entrenched beliefs continue this. Also funding money is all based around the genetic theory If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria Cancer is a result of the industrialization as a society Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria) These are all secondary - the root cause is damage to the respiration Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein) To avoid cancer it’s as simple as avoiding diets and lifestyles that risk damage to the mitochondria Metabolic therapies need to at least be options for people Problem is doctors aren't aware of them or aren't trained on them Therapeutic ketosis is a medicine - it’s different than just a diet (which is a turn-off to a lot of medical professionals) There’s therapeutic weight loss and toxic weight loss Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet ROS damages tissues and is why you age He published the glucose-ketone index calculator People need to realize sweets are a treat once in awhile - not an everyday thing The food industry has played into our ancient desires for sweet Otto Warburg studied cancer in the early 1900s He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid Because their mitochondria are defective they can’t switch back to oxidative phosphorylation He recently published a paper filling in the gaps from Otto Warburg’s work Missing link was the glutamine that cancer cells can also use Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells He’s developed the press-pulse system in his lab to attack tumors strategically Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution He’s having trouble getting funding for this for some reason One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem People are going to have to participate in the management of their disease and the culture of the diseases has to change Another problem is the high cost of these standard therapies - people have to pay $400k His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/ If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus The wheelchair doesn't cause your legs to not work Needle biopsies are putting people at risk and are pointless He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine What do critics of his views say? They try to create doubt They rely on private funding and some great organizations supporting this research Travis Christofferson’s foundation https://foundationformetaboliccancertherapies.com His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/ Dr. George Yu’s foundation https://yufoundation.org Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn Dr. Seyfried’s book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/   Preorder the film here: http://indiegogo.com/projects/food-lies-post Support me on Patreon! http://patreon.com/peakhuman    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Sapien Movement: http://SapienMovement.com   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg   Theme music by https://kylewardmusic.com/

In This Episode We Discuss Role of mitochondria in lifespan regulation and prevention of metabolic diseases Health-promoting effects associated with: low caloric intake, reduced glucose metabolism, physical exercise, sirtuin signaling & more How Prof. Ristow’s findings go against the popular “free radical theory of aging” How increased formation of reactive oxygen species (ROS) within mitochondria can increase longevity ROS causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity Mitochondrial hormesis or mitohormesis Human vs. non-human trials How do insulin, protein and resveratrol affect longevity? NAD Caloric restriction vs maintenance of lean physique for longevity Head of Institute of Translational Medicine at ETH Zurich and heads up the Energy Metabolism Laboratory. Prof. Ristow has been involved in research for many years examing Biochemistry and Physiology of Aging, Exercise, Obesity, Type 2 Diabetes. Prof. Ristow’s group are interested in the biochemical and molecular basis of longevity — in particular the role played by mitochondria in lifespan regulation and prevention of metabolic diseases. Contrary to the widely re-iterated ‘Free Radical Theory of Aging’, his group have been the first laboratory to show that the health-promoting effects associated with low caloric intake, physical exercise and other lifespan-extending interventions like sirtuin signaling are caused by increased formation of Reactive Oxygen Species (ROS) within the mitochondria, causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity, a process called mitohormesis. AUSTRALIA SEMINARS: https://sigmanutrition.com/australia/

Our own Scientific Director and coach Megan Roberts is back on the podcast today to discuss an important but often misunderstood aspect of health and longevity: oxidative stress.  It’s a condition associated with numerous chronic health problems including cancer, diabetes and cardiovascular disease. Today we cover everything you need to know about oxidative stress: what it is, what causes it, how to know if you’ve got it, and how to fix it.  If you want an objective assessment of your own oxidative stress burden, try using our Blood Chemistry Calculator.  The calculator, powered by a machine-learning algorithm, analyzes your own basic lab work to produce a single Oxidative Balance Score that you can use to track progress over time. Note: During this podcast, you’ll hear us talk about the “Oxidative Stress Score” on the Blood Chemistry Calculator Report.  This has since been renamed the Oxidative Balance Score.   Here’s the outline of this interview with Megan N. Roberts: [00:02:20] Blood Chemistry Calculator. Example report here. [00:04:52] Free radicals. [00:05:47] Oxidative stress: not always bad.  Study: Pizzino, Gabriele, et al. "Oxidative stress: Harms and benefits for human health." Oxidative medicine and cellular longevity 2017 (2017). [00:06:13] Reactive Oxygen Species (ROS). [00:07:52] Hormesis. [00:08:47] Podcast: The High-Performance Athlete with Drs Tommy Wood and Andy Galpin. [00:09:04] Supporting adaptation vs. recovery. [00:10:07] High dose vitamins, polyphenols. [00:12:05] Diseases associated with increased oxidative stress. [00:13.30] Lipid peroxidation. [00:14:12] Metabolic Fitness Pro. [00:15:46] Factors that increase oxidative stress. [00:17:11] Gamma-glutamyltransferase (GGT). [00:19:24] Bilirubin. [00:20:05] Uric Acid; Study: Sautin, Yuri Y., and Richard J. Johnson. "Uric acid: the oxidant-antioxidant paradox." Nucleosides, Nucleotides, and Nucleic Acids 27.6-7 (2008): 608-619. [00:23:52] Albumin. [00:24:26] HDL. [00:24:53] Podcast: Health Outcome-Based Optimal Reference Ranges for Cholesterol, with Dr. Tommy Wood. [00:25:05] Lipopolysaccharide (LPS). [00:26:53] Ferritin; Study: ORINO, Kouichi, et al. "Ferritin and the response to oxidative stress." Biochemical Journal 357.1 (2001): 241-247. [00:27:08] Fenton Reaction. [00:28:46] Nutritional immunity: PubMed. [00:31:26] The poor misunderstood antioxidant. [00:33:40] Dietary sources of antioxidants. [00:35:12] Supplementation can be contraindicated. [00:35:45] Measuring oxidative stress. [00:37:50] Podcast: Risk Assessment in the Genomic Era: Are We Missing the Low-Hanging Fruit? with Dr. Bryan Walsh. [00:38:21] Oxidative Balance Score. Example here. [00:40:00] What to do if oxidative stress is elevated. [00:40:44] Study: Bhatnagar, Anubhav, Yogesh Tripathi, and Anoop Kumar. "Change in oxidative stress of normotensive elderly subjects following lifestyle modifications." Journal of clinical and diagnostic research: JCDR 10.9 (2016): CC09. [00:41:30] Nutrition, digestion, absorption. [00:42:15] Avoid Polyunsaturated fatty acids (PUFAs). [00:44:20] Minimally processed diet. [00:46:22] Wild Planet sardines. [00:47:27] Hormetic stress; Hormetea. [00:48:14] Podcast: Hormesis, Nootropics and Organic Acids Testing, with Dr. Tommy Wood. [00:48:26] PHAT FIBRE is currently sold out. [00:48:55] Four Sigmatic 10 Mushroom Blend. [00:49:23] Sleep, blood donation. [00:51:02] Study: Islam, Md, et al. "Dietary phytochemicals: natural swords combating inflammation and oxidation-mediated degenerative diseases." Oxidative medicine and cellular longevity 2016 (2016). [00:55:57] bloodcalculator.com. [00:56:43] Mobile phlebotomy.