Podcasts about Snape

It's time for a very important H-word to be introduced to Harry. No, Fat Lady, it's not the one you experienced over your holiday break! Join the MuggleCasters as we discuss Chapter 17 of Half-Blood Prince, in which Dumbledore introduces Harry to 'A Sluggish Memory'. The Fat Lady seems to be telling herself to practice abstinence after the holidays. Sounds like it was a party in the portraits over Christmas! How do students end up missing the new Common Room passwords? Is it the school's fault, or is it the students? It's time for the students to learn how to apparate! ... For a price. We look at why Hogwarts and the Ministry might be charging for these additional lessons. Dismissive Dumby: Albus' ego is on full display as he plays off Harry's questions about Snape and Draco. As expected, Andrew comes in with a #DumbleDefense.  Back in the memories, Dumbledore shows Harry more about Tom Riddle's time at Hogwarts. Why didn't Dumbledore do more when Tom Riddle was at school and clearing causing trouble? We learn the real reason Dumbledore asked Slughorn back to teach, and we hear that certain H-word a first time (No, it's not 'Hufflepuff' or 'Horace') Connecting the Threads: There are some big parallels between Chapter 17 of Chamber of Secrets, and this Chapter of Half-Blood Prince! MVP: Which memory truly is THE most important memory Dumbledore has collected? Lynx Line: You've just learned to Apparate. Where are you going first? Quizzitch: While Lord Voldemort commits patricide by killing Tom Riddle Sr., what is the broader term used when someone kills a near-relative of theirs such as a grandparent? Learn more about your ad choices. Visit megaphone.fm/adchoices

Blood cancers are the fifth most common group of cancers in the UK. But for a small number of people, the condition may have an inherited genetic cause.  In this episode of Behind the Genes, we explore the role of genetics in blood cancer, and what an inherited risk means for patients and their families. Our guests explain what blood cancer is, how inherited factors can increase risk, and why multidisciplinary teamwork is key to supporting families. They also look ahead to future advances, from whole genome sequencing to prevention trials.  Our host Amanda Pichini, Clinical Director at Genomics England, is joined by:  Dr Katie Snape, Principal Clinician at Genomics England and Consultant Cancer Geneticist  Bev Speight, Principal Genetic Counsellor Dr Sarah Westbury, Consultant Haematologist “By doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.”  You can download the transcript or read it below. Amanda: Hello, and welcome to Behind the Genes.  Sarah: When we think about blood cancers, it's a whole range of different conditions and when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers but also the way that those cells function, and so the range of symptoms that people can get is really variable.  Amanda: I am your host, Amanda Pichini, clinical director at Genomics England and genetic counsellor.  Today I'll be joined by Dr Katie Snape, principal clinician at Genomics England and a consultant cancer geneticist in London, Bev Speight, a principal genetic counsellor in Cambridge, and Dr Sarah Westbury, and haematologist from Bristol.  They'll be talking about blood cancers and the inherited factors that increase blood cancer risk.  If you enjoy this episode, we'd love your support, so please subscribe, rate and share on your favourite podcast app.  Let's get started.  Thanks to everyone for joining us today on this podcast, we're delighted to have so many experts in the room to talk to us about blood cancer.  I'd love to start with each of you introducing yourself and telling us and the listeners a little bit about your role, so, Sarah, could we start with you?  Sarah: Sure.  It's great to be here.  My name's Sarah Westbury, and I'm a consultant haematologist who works down in Bristol.  And my interest in this area is I'm a diagnostic haematologist so I work in the laboratories here in the hospitals, helping to make a diagnosis of blood cancer for people who are affected with these conditions.  And I also look after patients in clinic who have different forms of blood cancer, but particularly looking after families who have an inherited predisposition to developing blood cancer.  And in the other half of my job, I work as a researcher at the University of Bristol.  And in that part of my job, I'm interested in understanding the genetic basis of how blood counts are controlled and some of the factors that lead to loss of control of those normal blood counts and how the bone marrow functions and works.  Amanda: Thank you.  That's really interesting, we'll be looking forward to hearing more about your experience.  Bev, we'll come to you next.  Bev: Thank you.  Hello everyone, I'm Bev Speight, I'm a genetic counsellor, and I work at Addenbrooke's Hospital in Cambridge.  I work with families with hereditary cancers in the clinical genetic service, and for the last six years or so have been focused on hereditary blood cancers.  So we've been helping our haematologists across the region to do genetic tests and interpret the results, and then in my clinic seeing some of the onward referrals that come to clinical genetics after a hereditary cause for blood cancer is found.  I'm also part of the Council for the UK Cancer Genetics Group.  Amanda: Thank you, Bev.  And Katie, over to you.  Katie: Hello, I'm Katie Snape.  I'm a genetics doctor and I am a specialist in inherited cancer.  So we look after anyone who might have an increased chance of developing cancer in their lifetime due to genetic factors.  I am the chair of the UK Cancer Genetics Group, so that's a national organisation to try and improve the quality of care and care pathways for people with inherited cancer risk in the UK.  And I have a special interest in inherited blood cancers through my work at King's College Hospital, I work in the haematology medicine service there seeing individuals who might have or have been diagnosed as having an inherited component to their blood cancers.  So it's great to be here.  Amanda: Excellent, thank you for those introductions.  I'd like to then dive right in and understand a little bit more about blood cancers.  So, Sarah, could you tell us a little bit more about what blood cancer is?  Sarah: Yes, sure.  The term blood cancer is used to describe a whole range of different kinds of cancer, all of which affect some part of the blood or sometimes parts of the immune system that kind of gets represented as part of the blood.  So it's really describing a big group of conditions rather than one single kind of condition or entity itself.  But like any form of cancer, we understand blood cancers as being conditions where because cells as part of the blood system are rapidly dividing and normally doing so under really well controlled circumstances to produce just the right balance of blood cells and just the right number of those cells.  In a cancer affecting those cells, we see that that loss of control results in either too many of one type of blood cell being produced or too few, or that balance being lost.  And like any form of cancer, this is because of genetic changes that happen in individual cells that then go on to grow in a way that is not controlled and well regulated.    And because when we talk about blood cancer we're talking about such a wide range of different kinds of cancer affecting different cells within that blood system, there's a really wide range of different conditions.  From conditions that we might think of as being like a form of acute leukaemia, so something that produces often symptoms and signs in patients very quickly and they can often feel quite unwell quite soon and then get picked up with having this condition because they present feeling unwell.  All the way to chronic and slow growing cancers that can be found completely by chance and serendipity when blood tests are done for other reasons.  So when we think about blood cancers, it's a whole range of different conditions.  And when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers, but also the way that those cells function.  And so the range of symptoms that people can get is really variable, again depending on which of the blood cells are really affected by that.  And it may be that during the course of some of the conversations we have today in this podcast, we'll perhaps focus on particular kinds of blood cancer.  But like any cancer, it's that disruption of the normal growth and development of cells that means that the number and function of those blood cells has been disrupted in some way.  Amanda: Thank you so much for explaining that, Sarah, that's really helpful.  In terms of across the range of blood cancers, is that something that people can get at any age, and how common is it?  Sarah: It does depend, as we were sort of talking about that really wide range of different disorders that make up that group of blood cancers.  And individually each of those blood cancers is reasonably uncommon compared to cancers that we might typically think of, like breast cancer or colon cancer.  But actually, if you group blood cancers together, they make up quite a sizeable proportion, and they're actually as a group the fifth most common form of cancer that's diagnosed in people in the UK.  In adults in particular we think that perhaps people diagnosed with leukaemia would make up about 3% of the new diagnosis of cancer made in any year.  Amanda: So coming to you, Bev, when we talk about inherited blood cancers, what are the differences between those and blood cancers more generally?    Bev: So at point of diagnosis, it may not be obvious that somebody with a new blood cancer diagnosis is one of the minority of people in that big group as Sarah has described, who has an inherited cause.  So it may not be immediately obvious.  However, in the last few years certainly, it's become more and more routine to do quite broad genetic testing.  Often on a bone marrow sample or blood, because that is done looking for genetic changes, which are part of all cancer and we find within cancer cells, that can help with treatment planning.  It can also find that there is an inherited cause to that new blood cancer diagnosis.  Sometimes that might not be clear cut, sometimes that might be inferred from the genetic tests that are done on the blood or the bone marrow. And the proportion of blood cancers in that huge group which do have an inherited cause is fairly small, the actual proportion will depend a bit on the age of the patient and the specific subtype of blood cancer.  Amanda: Okay, and could you talk us through how some of those inherited genetic factors can increase the chance of a person developing blood cancer, how does that work?  Bev: Yes, so if we know that there is an inherited cause for blood cancer, then what we mean by that most of the time is that a change in a single gene has been found.  And that there is enough research evidence and enough known about that specific change in that gene to say to the person who's been diagnosed, there is at least in part or perhaps a full explanation for why that blood cancer has developed and this could be shared in the family.  So at that point it's information that not only has implications for the person in treatment, but also their relatives.  Depending on what sort of gene alteration it is and which gene it's found in, there are different inheritance patterns, and that changes the sorts of information that we give about risks for relatives.  So for lots of the genetic tests that detect an inherited cause in adults when they're diagnosed, that's most often what we would call an autosomal dominant inheritance pattern.  Essentially that means you only need to have one gene alteration which is in that person's normal non-cancerous DNA inherited from a parent and can be passed onto a child.  And for people in the family who have inherited this one genetic change, then they are likely to be at increased risk of developing blood cancer.  Sometimes with particularly the children's blood cancers, if an inherited cause is found, it can be a different pattern, which we call autosomal recessive.  And that's where two gene changes are found and one has been inherited from each parent.  So parents might be what we call carriers and have one each just by chance, both have been passed onto a child who has developed blood cancer either in childhood or possibly later on, and that's the pattern we call autosomal recessive.  There are other inheritance patterns too.  The third one that we come across being X-linked, and so that has a gender component.  That's where there's a change on the X chromosome, women have two X's, and men have one X and one Y.  So sometimes with the X-linked conditions we're more likely to see the clinical signs of a condition in boys and men because they've only got that one X chromosome.  But those are less common in the context of talking about hereditary blood cancers.  Amanda: Thank you.  That's really helpful to understand.  So it sounds like you're saying that these forms of blood cancers that are caused by a single gene are relatively rare.  And also by having one of these changes, it's not a given that that person will develop a blood cancer, but it makes them more likely, and how likely that is might depend on the inheritance pattern or the type of condition.  Bev: That's right.  So what we're saying is it can give either part of full explanation for the blood cancer diagnosis, and it could confer a risk to family members, but that doesn't mean they definitely will develop it.  We're talking about an increased risk compared to the population risk.  Amanda: Right.  I can imagine for those families to some extent it might be helpful to know the underlying reason why they had that blood cancer, but again, that's just a small proportion.  So, Katie, could I come to you next?  What about the rest of all the blood cancers, how do they occur?  Katie: Yes, thanks, Amanda.  So most blood cancers will occur just by chance.  We also know that there are some environmental factors that can increase the risk of blood cancers, so, for example, serious radiation exposure, something like that.  What Bev has described is where there is this sort of quite rare condition where there is a kind of single gene that's really important for the blood cells in terms of keeping those control mechanisms that Sarah described.  And that's not working properly, which has increased the risk of a blood cancer.  But we also sometimes see some families where there is more blood cancer, or the same type of blood cancer in that family than we might expect by chance.  We think that's probably not due to a single high risk genetic factor, but might be due to kind of multiple lower risk genetic factors that are sort of shared by close family members and can add up together to increase the risk a little bit.  And we call that familial risk or polygenic risk.  We don't have a test for that at the moment.  We wouldn't offer usually any extra screening or testing to those families, but we would just suggest obviously family members are aware of any signs of symptoms of blood cancers and seek any advice if they're concerned.  But, you know, the majority of blood cancers are not due to genetic factors, and it's sort of environmental or chance or bad luck. Amanda: Okay, so it's clear that obviously blood cancer is almost an oversimplification, within that category there's so many different types, so many ways that it could happen in a person.  So, Bev, if we're dealing with that type of blood cancer that is inherited or has some heritability, can you tell us more about what that means for the family?  What kind of impacts do you see that having for them?  Bev: Yes, of course.  So clearly this is another layer of information that's often coming at a family during a time where somebody is often recently diagnosed with blood cancer of one sort or another and is having to take in a lot of information about treatment and all of the uncertainty and anxiety that goes with that.  So for this minority of patients and families where there is new information about an inherited cause, that needs conveying in a timely but sensitive way, bearing in mind what else is happening.  And for some people it can come as a major shock and really an additional burden at that time.  I think the reaction to that will of course depend on lots of factors.  And what we also see is that this question about a new cancer diagnosis of any sort, including blood cancers, can generate the question in people's mind, particularly if they've got children, about does this change the risk for relatives?  So sometimes this new information that, actually, there is an inherited cause is an answer to a question that families have already got.  And that might be because of what Katie's described as familial clustering, there might already have been this known history in the family. So sometimes this information can feed into that and actually be quite a helpful answer.  But it's quite normal for families to feel quite mixed about this and for different family members to have a different approach to it.  When there's the offer of what we would call predictive testing, if we found a change in a single gene in somebody with blood cancer which we're saying is a hereditary cause for that, that might open the door for relatives to access predictive testing.  I.e., the opportunity to discuss and possibly take up a genetic test for themselves when they haven't had cancer themselves, but there's an opportunity to try and quantify whether or not they're at increased risk.  We know in families the uptake of those kinds of tests is different, and a lot of it is to do with timing and the way people respond to this in families might depend on their response to the cancer diagnosis in their relative, and of course what else is going on in their life at the time.  This aspect for the family is where clinical genetic services come in, because these initial tests in the person with blood cancer are done in their haematology/oncology setting, and normally the results about an inherited cause has been found are conveyed through that service.  That's when a referral to clinical genetics happens.  And in our specialist service we're addressing those additional concerns for the family which arise because of this diagnosis. Amanda: Thanks, Bev, for explaining that.  Sarah, coming back to you.  Could you tell me then if someone has an inherited blood cancer does it also change the way that the patient is treated? Sarah: Well, it certainly can do, and again, it does depend a little bit on the specific circumstances of that particular person and the form of inherited blood cancer predisposition that they have.  But certainly if we think about treatment as a whole, then for a lot of people it does affect the way that we might recommend treatments or look after them and their families.  So, for example, for some patients who have a diagnosis of an inherited form of blood cancer, we know that some treatments might be more or less effective for their particular set of circumstances.  And so that can sometimes influence the specific treatment recommendations that we would make, particularly thinking about, for example, the risks that the cancer might come back again after it's been treated.  Or thinking about whether or not some of the typical drug regimes that might be used might be perhaps more likely to cause them side effects or problems with tolerating that treatment.  So it can certainly make some changes in that respect. For some people, to be fair a minority of people with blood cancers, they may need a stem cell transplant as part of their treatment to hopefully cure them of their blood cancer.  And this as I say is a treatment that's required for a minority of patients as a whole who have a diagnosis of a blood cancer.  But for those people who have got an inherited predisposition and who might be recommended a stem cell transplant as part of their treatment, then knowing about a familial risk for this condition can also be really important.  For making sure that if a family member is being considered as a donor for example that we're being really careful to make sure that we're not choosing a donor that might also be affected by the same underlying blood cancer predisposition.  Because this can obviously cause problems for the person that's receiving the stem cells if it turns out that the person they're receiving them from actually has the same inherited condition as them.  So in that respect knowing about the underlying predisposition and genetic cause for their cancer can be helpful.  But in a more sort of general sense, yes, the other thing that it can have a big difference for is that some of these inherited cancer predispositions and syndromes also have other health conditions associated with them.  So it might be that that genetic diagnosis predisposes somebody not only to a form of blood cancer but to other health conditions as well.  And so actually knowing about that diagnosis can help their haematologist then make sure that they're linked in with the right other medical teams to make sure that those other health conditions are identified if they're present and taken care of.  And then I think really coming back to what Bev has already touched on, there's the sort of bigger picture of just how people are looked after in their own right but also as part of their family unit.  And making sure that they're given the right information and advice about their health, but also thinking about other family members.  And particularly for younger patients who perhaps either are just starting their own families or for whom that's not yet a consideration, making sure that they've got the information to understand what might be relevant for future family members, if that makes sense.  So it's not necessarily true to say that for every individual patient knowing that there's an inherited blood cancer present will necessarily directly affect the way that the treatment is offered.  But you can see that as a part of a bigger picture for a lot of patients, it will make a difference to their care as a whole.  Amanda: And you can really see how the impact is very sort of multigenerational and is going to affect people at all ages and stages of their life, so that's really interesting.  Katie, Bev spoke a little earlier about the fact that there are genetic tests that can help tell us if blood cancer is inherited.  Could you tell us more about what the tests involve, and some of your experience taking families through this?  Katie: There's sort of two main different ways that we might identify somebody has an inherited cause for their blood cancer through testing.  So traditionally what has happened, as Bev and Sarah sort of discussed before, is that when a person is diagnosed with a blood cancer, we either take a sample of their blood or bone marrow.  To try and look at what are the changes within those cells that have driven that cell to become a cancer cell and have driven this blood cancer to develop.  And a lot of the time, as we've said, it's not inherited, it's not genetic, so they're what we call acquired changes, they're changes that have just happened in the bone marrow or to the blood cells that have caused that kind of particular cell to become a cancer cell.  And it's really important that we look at those because that can help both diagnose the blood cancer, it can give us information about how serious that blood cancer might be, and it can also help us guide our treatments and therapies.  And so if we do those testings, they're primarily done within haematology for those sort of diagnostic or prognostic or treatment purposes.  We do sometimes see then a change that looks a bit suspicious that it might be inherited for various reason.  And if we see something that is in the cancer and it looks like there's a potential it could be inherited, we would go on and do a second test.  So usually because we can't do a blood test because the cancer's in the blood, we would take a skin biopsy.  And then we would look and see, well, is this change also present in the skin?  And if it is, then that indicates that that change is in all of the cells of the body, because it's in both the blood cancer and it's in the skin, and therefore it's likely to be inherited.  So that's one thing that we do.  And I think that that can be quite challenging for patients.  Because they go in to have a test for their blood cancer and then suddenly were being told, “Well, actually, we've also found something that might be inherited,” and it is something then that other members of the family might have.  And as Sarah said, potentially that means that even if your relative was offering to be a bone marrow donor for you, they might not be able to if they also carry the same thing.  And so that can be quite tricky just in terms of making sure that we're guiding the patient and their family members through that process.  And then thinking about the work that Genomics England does, particularly with whole genome sequencing, and this is particularly offered for children and young adults in the paediatric setting.  But I think we're also increasingly, as we progress we'll perhaps talk about this a bit, moving towards whole genome sequencing for adult blood cancers more routinely as well, that that is offered as a sort of standard of care.  And what whole genome sequencing is, is it is looking at the entire genetic instruction manual in both the blood cancer cells and in the cells that we're born with, to look at the inherited or germline genome as well.  And the reason that we look at both the cancer cells and the inherited or germline genome is because what we're trying to understand is firstly, are there any inherited changes that have led to the blood cancer developing?  But also, what are the changes that have just occurred in the cancer cells that are going to help us to diagnose and treat that blood cancer?  So by doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.  And so, again, when we're talking to patients, we have to explain to them that we're going to be looking at their entire genetic information.  And what's interesting about that is it might find things that are not only relevant to blood cancer, but very rarely other findings, incidental findings as well, or we might find things that we don't know about.  But I think certainly that's something that patients often feel very comfortable with having because it gives them the maximum amount of information.  Amanda: Thanks, Katie.  So it really sounds like there's a lot of advancements that are being made in genetic technology which potentially brings a lot of new things for you and Bev as genetic specialists, but also for you, Sarah, as a haematology specialist.  What does that kind of change for you, and I assume it's really important then for you all to be working together as a multidisciplinary team?  Katie: Yes, I mean, I think for clinical genetics, we were not involved in sort of haematology pathways for a really long time, and the haematologists are absolute experts in the genomic factors that drive blood cancers.  And certainly in my practice, it's really only been as the technology advanced that we really started finding more and more of these inherited factors, particularly in the adult setting.  Because I think in the paediatric and childhood setting, the haematologists again have been managing those conditions very well for years.  And I think there's places that we really interface and we really need to work together as a multidisciplinary team, understanding the genetic information, really understanding when something that we've seen in the blood cancer or the bone marrow could be inherited.  Do we need to check that?  What should that pathway look like?  But I think as you've said, a lot of these are actually really quite new conditions, particularly in the adult setting.  And we don't yet 100% know why do some people get blood cancer and some people don't when they have the same inherited factor.  What's the actual risk?  Are there any other factors modifying it?  What makes some people progress to develop a blood cancer and some people not?  And for that we really need to work together to try and gather the data and sort of capture people that have these inherited changes.  And hopefully develop a system and an infrastructure that we can follow it long-term and get a lot of information about long-term outcomes, both for individuals with cancer but also their families.  And also from looking at doing population studies.  Because I think we know that lots of people in the general population might carry some of these inherited changes and never develop a blood cancer as a result of this, certainly ones that seem a bit lower risk.  So we really need to work together to understand all of that.  But I'd be really interested in Sarah's views on that as well.  Sarah: Yes, sure.  So I think, as you say, Katie, haematologists have got a long history of understanding and interpreting genetic findings in the sort of acquired or somatic changes that we know are what occurs in some blood cells to drive the cancer forming in the first place. But this kind of newer integration of that with the germline testing is something that is becoming much more mainstream in haematology now, and I think something that people have had to sort of acquire new skills in this area to interpret that alongside.  I think as you say, that multidisciplinary working, where we're able to benefit from both sides of our expertise and knowledge and put that together is so valuable, particularly in those circumstances where there is some uncertainty.  And I think as a haematologist, one of the things that I really find a benefit both personally and professionally to help me navigate these tricky questions but that I also think patients benefit from is your expertise and ability to have those really quite tricky conversations with people who are not haematology patients, if that makes sense.  So they may be the relatives of patients who have a haematological diagnosis for example.  Who at the moment are entirely well and were just going about their daily business, and they're now told that they may or may not potentially have this inherited predisposition.  And I think that as haematologists, we're very used to dealing with potentially quite poorly patients, potentially quite scared patients who find themselves, you know, the recipient of all this quite difficult information.  But we're not necessarily so skilled and experienced at holding conversations with people who don't yet have that diagnosis.  And I think that that's a really rich area of mutual aid to one another as haematologists and genetic doctors, if that makes sense.  And I think your points about understanding actually the real risks and the nature history, as we would call it, of what happens to people who carry these variants that predispose them to blood cancers is something that we can probably only work out by working together.  And of course, working with the patients and families that are affected by these conditions so that hopefully for both sides in the future we'll be able to give much better advice to patients and their families.  Amanda: So, Bev, from your experience and as a genetic counsellor, what do you feel are the important things that patients and their families should know as they're going through this testing and diagnosis process?  Bev: The things I think families where there is a hereditary cause found should know is that with this new information comes a whole new referral to a dedicated service.  Who want to help patients and their family members at risk to navigate this, to adjust the information, and to make decisions that fit with them, about whether to have testing and the timing of that.  As we already said, where there is a hereditary blood cancer risk, that risk in family members is rarely 100%.  Depending on what the hereditary predisposition is in the family, we may be able to quantify that risk, sometimes we can't always.  And the other thing to know which links to that is that there is growing interest in research in this area.  That will really help us to improve care in terms of, for example, being able to quantify the risk of developing a blood cancer in relatives who are perfectly well that may have inherited these predisposition gene changes.  Or, for example, the other obvious place where we want to make improvements in terms of some sort of evidence-based surveillance for those people who want to find out that they have inherited the genetic change and are at increased risk.  Amanda: Thank you.  And overall there's been a lot I think we've been covering today that's probably going to be very new to many people.  Why do you think it's important to raise public awareness of inherited blood cancers?  Bev: There have been lots of public awareness campaigns about other cancers, as listeners probably can think about, in terms of for women checking their breasts and breast cancer awareness.  And perhaps there's been a bit less of that in general for blood cancers.  As we've already talked about, clinical genetics were not so involved in all of the genetic testing happening in blood cancers.  Because it wasn't so long ago in the history of how we think about inherited cancers in general that our suspicion of inherited causes in leukaemia was much lower than it is now.  So I think that awareness in the public probably will take a bit more effort to bring up.  But clearly public awareness about blood cancers in general, symptom awareness, and the fact that occasionally it can be something that is running in the family, clearly better public awareness of that means that people are empowered to ask the right questions.  And the questions that might already be in some way going through their minds of their haematology doctors or perhaps of their GP, if they've got a family history but are not affected themselves.  Amanda: Wonderful.  So, looking now to the future, Katie, what genomic advancements are we seeing or are we likely to see that could impact on the care of people with an increased genetic risk of blood cancer?  Katie: We touched a little bit, I think that whole genome sequencing is expanding.  And as we can turn that test around and get it back more quickly that might become more commonplace.  And I know Genomics England and the UK Haemato-oncology Network of Excellence have been doing a lot of work in that area.  We are very lucky now we have a national inherited cancer predisposition register that NHS England have set up with the National Disease Registration Service.  So that will enable us to capture individuals that have these sort of rarer but single gene disorders or conditions that increase the chance of developing blood cancers.  And that will enable us to do that sort of longer-term follow-up and get really more information.  We've touched on this already but I think there's really amazing research happening, why do some people develop blood cancers and some people don't, even though everyone carries the same underlying change that increases the risk?  And then I think really importantly, we're seeing now in some conditions, clinical trials of certain medications to see if that can actually prevent people who carry these inherited changes from progressing to developing blood cancers.  So I think all of those things are really exciting and will give us lots more information that we can then help patients and their families, particularly the sort of treatment and trials aspects.  Amanda: And, Sarah, on treatment and trials, how do think genomics might improve the treatment, but also the diagnosis of people with inherited blood cancers in the future?  Sarah: I think, you know, hopefully when we are able to accrue more information about these underlying genetic predispositions and how they actually then affect people's likelihood of developing blood cancer, we'll be able to build on what we have so far to make that just feel much more robust and evidence based.  And it feels like at the moment there are many of us struggling to bring together small threads of evidence that have been accrued in the UK but in other centres around the world that are also interested in understanding this inherited blood cancer risk.  In such a way that we can actually give patients and their families more clear information and advice about what that means to them.  And I think that in terms of the diagnosis of blood cancer, I think this is something that Bev alluded to.  If we could better understand who might benefit for example from having regular screening or monitoring blood tests performed to see whether we can detect an emerging blood cancer.  Versus identifying those people who actually, the chances of them developing a blood cancer are so small that doing those tests is likely to do them more harm than good.  Perhaps by just causing them to be anxious or have other sort of unintended consequences of that kind of testing.  So understanding something more about that natural history, as we've already alluded to, will hopefully improve our ability to go from the diagnosis of the predisposition condition to working out how to then diagnose the blood cancer on the back of that.  And with time, I think as Katie has alluded to, thinking about more specific treatments and more tailored treatments to the individual predisposition condition and the blood cancer.  So whether it's that you're intervening before the blood cancer has developed to try and reduce that happening, or whether it's that you're then treating the blood cancer after it's developed.  Understanding the genetic basis and what it is that causes that transition would be really helpful and I think that is something that will come but will take time.  And I think on a sort of national level what I would really hope to see over time is that we're able to use that improvement in evidence base to then be able to bring together perhaps more defined patient pathways.  So that if you're diagnosed with a particular condition, one of these leukaemia predisposition syndromes or another form of blood cancer predisposition, there's a recognised strategy and set of steps that should be taken for all of those patients.  To make sure that they're getting equity of care and make sure that everything is being done in a way that feels safe, sensible and appropriate across the country.  While still then enabling us to give really personalised treatment to that individual person and what that diagnosis means for them.  But I think until we've gathered more information and more evidence we are just in the process of trying to do that to then bring about those changes.   Amanda: If you enjoyed today's episode, we'd love your support.  So please subscribe, share and rate us on wherever you listen to your podcasts.  I've been your host, Amanda Pichini.  This podcast was produced by Deanna Barac and edited by Bill Griffin at Ventoux Digital.  Thank you for listening. 

This show is sponsored by BetterHelp – Sign up and get 10% off your first month at BetterHelp.com/SUPER  This show is sponsored by Shopify – Go to shopify.com/scb to sign up for your one dollar per month trial! Today Ben dives into the Wizarding World of Harry Potter to ask: What if Snape was in Gryffindor?  Dumbledore says he thinks they may have sorted him too early, and Harry calls him one of the bravest men he ever met. Would being sorted into Gryffindor make him one of the Marauders? Would he ever become a Death Eater? Would the prophecy ever be overheard?

It's back to the Potions classroom this week, as Ron pays the price for sloppy chopping and Draco milks his "injured arm." Snape's just trying his best to be happy, can you blame him for wanting to teach Ron a lesson? (Alice and Martha can). Please consider supporting us on Patreon! www.patreon.com/realweirdsisters New episodes are released every Monday and special topics shows are released periodically. Don't forget to subscribe to our show to make sure you never miss an episode!

Send a textIn this episode, we begin the second season of our version of the Harry Potter TV show. Enjoy!Topics/Summary:·      1:54 Let's set some goals. 1) Explore Hogwarts. We haven't seen the whole grounds by now, and there is so much more history to explore. 2) Develop relationships. Especially for arcs like Snape and Harry, beginning to see their relationship take form will lead to a huge payoff later on. 3) Begin Voldemort's arc. Tom Riddle is the main villain of this book, and we can use his past and memories to understand a little more about Voldemort. This Tom Riddle feels almost closer to the Goblet of Fire Voldemort than the back-of-the-head thing from last book.·      10:33 We begin in the days of old. That's what I wrote in my notebook. We should begin with the founders of Hogwarts and their dynamics. Salazar Slytherin wanted to keep Hogwarts for pure-blood students and that's why he was cast out, leading to the creation of the Chamber. ·      18:15 Moving forward through time. As the founders fall into the legend, the Chamber falls into legend with it. We lose a little bit of the gravitas if we snap forward in time and skip over the thousand years in the middle. We should end this section with Hagrid and Tom Riddle's time at Hogwarts, and seeing the Chamber open for the first time.·      25:24 Now we move into the present day. But not with Harry. The diary Riddle was the driving force in the Chamber, but something had to have worked in the background for that to happen. It would make sense for Voldemort himself to have given Lucius the diary and sent him off to get the gears turning.Having anything you want to hear or say? Click here for a voice submission or here for text. ThePotterDiscussion@gmail.comthepotterdiscussion.comNox

Jetzt ist Schluss, Schniefelus! So sagt zumindest Sirius, aber Snape hat eine wichtige Mission, er muss Harry unterrichten und wir kosten das so richtig aus - vor allem Ramon, der mal eine Zehe in das Team-Snape-Becken hält und feststellt, dass das Wasser da ganz seiner Temperatur entspricht. Ob das ein Dauerzustand wird? Du möchtest mehr über meine Werbepartner erfahren? ⁠Hier findest du alle Informationen und Rabatt⁠ Komm in die Gruppe! Hier gehts zu unserem WhatsappKanal ⁠https://whatsapp.com/channel/0029VabF6h3H5JM0EN0DwU0X⁠ Tolkühnes Merch! ⁠https://shop.spreadshirt.at/tollkuehn-podcast/⁠ Instagram @tollkuehn_podcast Schaut auf unserem Discord Server vorbei: ⁠https://discord.gg/hobbithoehle⁠ Falls du uns über Steady unterstützen willst: ⁠https://steadyhq.com/de/tollkuehn-podcast⁠ ⁠https://ko-fi.com/tollkuehn⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Snape's worst memory is that he regrets betraying Lily by referring to her hunted status and reinforcing it. That supports the notion that Hermione did a sort of favor for Marietta by preventing her from having the same guilt on her conscience. If Marietta later had to think about her murdered friend Cho and exactly what it was that led Cho to be found and punished, this stopping people from going there is a form of protectiveness without affection. For full show notes, transcripts, ways to contact the hosts or support the show, and more, visit hpafter2020.com.

As Valentine's Day approaches in the Muggle world, romance is also a focus in this area of Half-Blood Prince. Join Andrew, Eric, Micah and Laura as they watch Harry watch Draco, watch Hermione regret her revenge against Ron, and watch Snape learn that Harry is suddenly good at Potions.  New Throwback Content: This Saturday, February 14 at 11am ET, MuggleCast will stream the Chamber of Secrets PC Game LIVE on our Twitch! It will later be available on our YouTube channel. A listener recently reviewed us being “as cozy as a warm blanket on a cold day.” We're very touched! If you feel similarly, be sure to tell us by leaving a review. Chapter by Chapter continues with Half-Blood Prince, Chapter 15: The Unbreakable Vow The MC Pensive segment takes us back to an episode we recorded seven years ago. Hermione decides to take Cormac McLaggen to Slughorn's Christmas Party, just as Ron feared she would. Is this revenge satisfying for the readers? Do we feel bad when it doesn't work out for Hermione? Should love potions be taken more seriously than they are, by everyone? Harry is (rightly) worried. Eric asks, how does Cormac not know how to show someone a good time? Harry says that he kinda always thought Filch and Madame Prince were a thing. The hosts pick apart that offhand comment... ...and then we speculate. COULD that be a thing? Filch and Madame Prince? What do they have in common? How does Mrs. Norris feel? Is Snape's attempt to detect Draco's lying ethical? We know there's more in it at stake for him. Should Draco have been suspicious that Snape was working for Dumbledore, based on Snape's emphasis on the importance of DADA for Crabbe and Goyle? What If?: Harry overheard that Draco's mission was to kill Dumbledore? What if it was said aloud? What would Harry do? Odds and Ends include the Number 12 (our favorite), and vampires. Our MVP segment asks who is the best character to take to Slughorn's Christmas party? Our Lynx Line topic this week for Slug Club patrons: Who should Snape and Trelawney have invited as their dates to Slughorn's party? And, what would their pick-up lines have been? Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

Die Harry-Potter-OperWie schön wäre bitte eine Harry-Potter-Oper? Eine Arie von Snape kurz vor seinem Tod? Mega! Findet zumindest Martin. Sophia sieht das allerdings ganz anders. Was denkt ihr?Aber mal zum eigentlichen Thema. Denn es ist so weit: Umbridge hat sie entdeckt! Die DA ist aufgeflogen. Dobby warnt die Anwesenden zwar noch rechtzeitig, doch nun beginnt die wilde Flucht. Aber ist das eigentlich eine gute Idee? Wie funktioniert der Raum der Wünsche überhaupt? Wären sie darin nicht sicher gewesen? Unter welchen Umständen hätte Umbridge dort hineingekonnt? Fragen über Fragen.Egal wie: Harrys Lösung ist, auf jeden Fall, dass alle Kopflos aus dem Raum rennen. Als heldenhafter Anführer bildet er das Schlusslicht. Uund natürlich ist Malfoy sofort zur Stelle, um Harry abzufangen. Umbridge kommt, packt ihn direkt beim Schlawittchen und schleppt ihn zum Büro des Schulleiters. Dort wartet bereits ein Tribunal auf ihn, angeführt von Cornelius Fudge. Damit beginnt eines der spannendsten Wortgefechte des gesamten Buches zwischen Dumbledore und dem Zaubereiminister. Wird Dumbledore es wieder schaffen, ihn rauszuboxen? Oder wird diesmal das Ministerium siegen? Erfahrt es in der neuen Folge!​Viel Spaß dabei!​Hier geht's zu unserem Whatsapp-Kanal: https://whatsapp.com/channel/0029VbB8C00CRs1obJUivo2Z​Wir haben auch eine Patreon-Seite!​Schaut doch mal vorbei, es gibt Bonus-Episoden, Sticker und andere aufregende Dinge! Besucht uns auf den sozialen Netzwerken, unserer Webseite und erzählt euren Freunden von uns! Vielleicht haben die ja auch Lust auf einen Harry-Potter-Podcast!​Webseite: www.Happy-Potter.netPatreon: www.patreon.com/happypotterDiscord: https://discord.gg/2EajMaGXpcFacebook: www.facebook.com/happypotterpodcastInstagram: @happypotterpod​Und wir haben jetzt auch Playlists mit unseren Lieblingssongs:​Martins Playlist:https://open.spotify.com/playlist/2IBxDsPVm1UdNBiW2QkgEJ?si=rU6HLkoFQfGGjvab8g8yEQ&pi=e-bKuIHap7RWCu​Sophias Playlist:https://open.spotify.com/playlist/0kuOP0TujMhrqOWzLwUH1O?si=9LIZkc2nQTOajHPaqpP_RA&pi=e-tc6w0NgQRo-W Hosted on Acast. See acast.com/privacy for more information.

Alice and Martha return to Sorcerer's Stone for a unique Hermione and Ron POV page. Draco is full of witty jabs, Neville is full of amazing comebacks, and Ron is surprisingly composed. And yes, Snape's refereeing. Please consider supporting us on Patreon! www.patreon.com/realweirdsisters New episodes are released every Monday and special topics shows are released periodically. Don't forget to subscribe to our show to make sure you never miss an episode!

Vi er nået til det - der er ingen vej uden om... Dumbledore dør! Lyt med når vi går i dybden med Dumbledores sidste minutter, og vender både Malfoys og Snapes rolle i det. Der er giga action i disse to kapitler, hvor både dødsgardister og ordensmedlemmer kæmper, mens Harry jagter Malfoy og Snape. Og så går vi også i dybden med R.A.B, der har efterladt en besked til Voldemort i medaljonen. Hvem var R.A.B, og hvad var hans rolle i fortællingen? Det viser sig at være ret så spændende.

Potter Revisited Episode #103 Family Dinner AKA Harry Potter and the Order of the Phoenix, Chapter 5 "The Order of the Phoenix" This feels like a true family dinner  Turns out this creepy house belongs to Sirius as he is the last Black alive Shay discusses the layout of Grimmauld Place and how it shows the class level of Sirius' family  Harry and Sirius are finally reunited and both seem to be angry with Dumbledore  Shout Out to Greenland!  We agree with Molly, no smoking at the dinner table Mundungus  Does Sirius feel a camaraderie with Mundugus?  We see another side to Sirius - he seems more bitter and reckless than GoF Sirius  Sirius and Snape are still at odds - that forced handshake can't undo years of loathing, Dumbledore  The Twins are obsessed with saving time with magic  Harry is finally given the opportunity to ask some questions  Molly and Sirius have some real tension  Thank God Lupin is around to defuse the situation between Molly and Sirius Shay thinks it was irresponsible for James and Lily to name just Sirius Godfather of Harry Is Molly upset because Sirius has the "authority" over Harry's wellbeing since he is Godfather  Fudge is a true evil politician  The weapon being the prophecy - should Harry have been aware of this earlier so it couldn't be used against him?  Is Molly struggling with the lack of control? There are a lot of things going on with her family Snape Sucks count for Chapter 5: 0 Email any thoughts, questions or feedback  potterrevisitedpodcast@gmail.com Music: Shelter Song by Alexander Nakarada (www.serpentsoundstudios.com) Licensed under Creative Commons BY Attribution 4.0 License https://creativecommons.org/licenses/by/4.0/ Follow Us:  Facebook  https://www.facebook.com/potterrevisited Twitter https://twitter.com/potterevisited Instagram https://www.instagram.com/potterrevisited_/ Youtube https://www.youtube.com/channel/UC4v2Xt0OIQ8_LCVYhKf2S5A TikTok https://www.tiktok.com/@potterrevisited    

Somebody is being a grown-up, and he is taking on a dangerous duty so the kids don't have to fend for themselves. "It's not your job to find out what the Dark Lord is..." "That's your job, isn't it?" "Yes, it is." This is what it looks like when Snape stops hiding his agenda and tells something, the rare thing that is true about himself from every perspective. For full show notes, transcripts, ways to contact the hosts or support the show, and more, visit hpafter2020.com.

This week, it's the moment in All The Young Dudes that we knew was coming and is just as rough as we anticipated: the Snape-almost-eats-it-or-should-we-say-almost-gets-eaten prank. It's the immediate aftermath, Remus is in an emotional maelstrom and rapidly being drawn back into his isolated and surly ways, and your hosts are processing an especially awful political landscape. Join us for the…fun?Support the showSupport FFH on Patreon: patreon.com/thefoxandthefoxhoundFollow us!IG: @thefoxandthefoxhoundTikTok: @thefoxandthefoxhound

Hoy nos ponemos un poco serios, pero con mucho respeto para hablar de puro profesionalismo. Vamos a recordar a esos grandes del cine que, sabiendo que su tiempo estaba por terminarse, decidieron regalarnos una última actuación con todo el corazón. Eso es amor al arte y no tonterías.

This week, be careful what you say, be careful what you touch! From sinister nonverbal spells to cursed jewelry,  Hogwarts is more of a security nightmare than normal! Join Andrew, Eric, Micah, Laura and Channell as they brave the frigid cold of Hogsmeade.  Welcome, Slug Club member Channell! Music to our ears! Hans Zimmer will score the new Harry Potter TV Show! Chapter-by-Chapter continues with Half-Blood Prince, Chapter 12: Silver and Opals Where the hell is Dumbledore and what is he doing? Harry is asking, not us! What is it about the Prince that endears Harry to him? How are spells created in the Wizarding World? We explore this question in great detail in this week's Bonus MuggleCast and Andrew even challenges the hosts with some creations of his own! Reckless Harry! Why is he casting spells with no clue what they do? Should Harry use the Prince's work to help curry Slughorn's favor? Hot Take: Snape would have been a great teacher if he taught with the same enthusiasm he has when writing his notes! Do we think Slughorn is even more interested in Harry given it's been so hard to get him to come to the Slug Club? Connecting The Threads to Chamber of Secrets: More bathroom problems! Why doesn't anybody believe Harry? The evidence is starting to pile up against Draco! Our MVP segment asks what would have happened if Dumbledore had received the cursed necklace? Our Lynx Line topic this week for Slug Club patrons: how could Hogsmeade do a better job of protecting visitors and residents from security nightmares? Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

Es geht endlich weiter bei "Spion der Nächte". Wir begleiten Snape in seine Wohnung und treffen nicht nur auf Wurmschwanz sogar auf den dunklen Lord persönlich! Es wird richtig spannend und natürlich lustig! Es gibt neuen Merch: https://www.seedshirt.de/shop/schokofroescheshopIhr wollt uns FanArt schicken oder Sticker von uns bekommen?Schreibt uns an:Postfach 71053281455 München

Se han cumplido 10 años de la muerte de Alan Rickman, el gran actor inglés de voz grave y presencia imponente que nos dejó interpretaciones inolvidables como las del profesor Snape de la saga “Harry Potter”, el criminal Hans Gruber de “La jungla de cristal” o el caballero enamorado de “Sentido y sensibilidad”. En este episodio recordamos su vida y su obra. Tenemos nuevo “villano odioso” esta semana, aunque en este caso también es un personaje divertido y hasta cierto punto entrañable: Biff Tannen, el abusón de la saga “Regreso al futuro”. El director Miguel Ángel Guerra nos habla de unos míticos decorados en Hoyo de Manzanares, cerca de Madrid capital, donde se rodaron muchas películas del Oeste en los años 60, entre ellas “Por un puñado de dólares” de Sergio Leone. Y en la sección dedicada al cine de aventuras tenemos esta vez “Los vikingos” de Richard Fleischer, con Kirk Douglas y Tony Curtis empuñando la espada.

This episode is sponsored by BetterHelp. Go to http://betterhelp.com/super for 10% off your first month. Go to http://factormeals.com/super50off and use code super50off to get 50% off your first box, plus Free Breakfast for 1 Year. How does Voldemort fly without a broom? It's one of the most shocking moments in Harry Potter and the Deathly Hallows—and it's never explained. In this video, we uncover how unsupported flight works, why it horrified the Order of the Phoenix, and how it connects directly to Occlumency, emotional detachment, and Voldemort's inability to love. By comparing Voldemort, Snape, and Harry, we reveal why only two wizards ever achieve this ability—and why it's not a power Harry should want.

LK:  We know, from him having put three memories in the Pensieve, that Snape has his own important things at risk here.  JC: My first read with it was that there were things that he didn't want Harry to know, but now I'm like, 'Oh, there's things he doesn't want the Dark Lord to know.' He's not worried about Harry knowing. LK: If Voldemort sees things, he doesn't have the emotional intelligence to put them together a certain way; if Harry sees those things, Harry does. For full show notes, transcripts, ways to contact the hosts or support the show, and more, visit hpafter2020.com.

Potter Revisited Episode #102 House Hunters International AKA Harry Potter and the Order of the Phoenix, Chapter 4 "Number 12, Grimmauld Place" Please forgive Tori's voice as she is getting over the flu We are back to discussing OOTP in 2026! We finally get our introduction to Grimmauld Place The way access to Grimmauld place is revealed to Harry seems similar to the magic of the Room of Requirement at Hogwarts Grimmauld Place definitely gives of some particular vibes which Shay discusses as if we are in an episode of House Hunters International  Shay loves hallways and closed living  Mrs Weasley seems stressed CAPS LOCK Harry makes an appearance  Is Harry really angry at Ron and Hermione, or just taking out his anger on them?  Ron and Hermione are good friends to allow Harry to take his anger out on them and not hold it against him  The Twins can apparate now and have great instincts on defusing the tension Harry brings  Ginny also appears and interacts quite normally with Harry for the first time  We are looking forward to Ginny's transition from younger sister to an actual character  Bill is a highly respected older sibling  Fred spills the tea about Bill and Fleur  Both Bill and Charlie have joined the order to help find and recruit members, but what about Percy?  Percy had a catastrophic falling out with Mr Weasley and his family - has this been building for a while?  We understand Percy was wrong about Dumbledore and Harry, however we sympathize with him on his family not respecting or valuing his interests/ambitions  Does Percy's high ambition stem from his father not having more (according to Percy) and him viewing that as a character flaw? Does Percy have some jealousy on how Harry fits into his family compared to himself?  Harry is being slandered in the press again Would Sirius actually allow Snape to stay for dinner?  We are introduced to Sirius' mother in the form of a screaming lifesize portrait that cannot be removed. Terrible person, but we respect the level of pettiness.  We are looking forward to the next few chapters set in Grimmauld place! Snape Sucks count for Chapter 3: 0 Email any thoughts, questions or feedback  potterrevisitedpodcast@gmail.com Music: Shelter Song by Alexander Nakarada (www.serpentsoundstudios.com) Licensed under Creative Commons BY Attribution 4.0 License https://creativecommons.org/licenses/by/4.0/ Follow Us:  Facebook  https://www.facebook.com/potterrevisited Twitter https://twitter.com/potterevisited Instagram https://www.instagram.com/potterrevisited_/ Youtube https://www.youtube.com/channel/UC4v2Xt0OIQ8_LCVYhKf2S5A TikTok https://www.tiktok.com/@potterrevisited    

Wie funktionieren eigentlich Gedanken? Dieses Mal sind wir Mal sehr philosophisch. Wie läuft das eigentlich mit Gedanken? Denken wir alle gleich? Sind wir in unserem Gedanken frei? Aber der der Reihe nach. Denn es ist Mal wieder Okklumentik Zeit. Und weil Harry darin immer noch sehr schlecht ist, bekommt Snape natürlich direkt raus, dass Harry eine Vision von Voldemort hatte. Die Gardinenpredigt folgt natürlich prompt. Dabei klingt Snape wie ein Elternteil, der einem Kind Vorwürfe macht. Warum macht er dass denn hier? Das ist immerhin seine Freizeit! So geht das nicht! Aber als Harry es dann richtig macht gefällt ihm auch nicht. Was genau er macht? Da müsst ihr wohl die Folge hören ;) Ach und wir haben ein wenig über eure Spotify wrapped gesprochen und was ihr so hört!​Und jetzt viel Spaß beim Zuhören! :)​Hier geht's zu unserem Whatsapp-Kanal: https://whatsapp.com/channel/0029VbB8C00CRs1obJUivo2Z​Wir haben auch eine Patreon-Seite!​Schaut doch mal vorbei, es gibt Bonus-Episoden, Sticker und andere aufregende Dinge! Besucht uns auf den sozialen Netzwerken, unserer Webseite und erzählt euren Freunden von uns! Vielleicht haben die ja auch Lust auf einen Harry-Potter-Podcast!​Webseite: www.Happy-Potter.netPatreon: www.patreon.com/happypotterDiscord: https://discord.gg/2EajMaGXpcFacebook: www.facebook.com/happypotterpodcastInstagram: @happypotterpod​Und wir haben jetzt auch Playlists mit unseren Lieblingssongs:​Martins Playlist:https://open.spotify.com/playlist/2IBxDsPVm1UdNBiW2QkgEJ?si=rU6HLkoFQfGGjvab8g8yEQ&pi=e-bKuIHap7RWCu​Sophias Playlist:https://open.spotify.com/playlist/0kuOP0TujMhrqOWzLwUH1O?si=9LIZkc2nQTOajHPaqpP_RA&pi=e-tc6w0NgQRo-W Hosted on Acast. See acast.com/privacy for more information.

This week's episode features Snape's first speaking appearance, both in the books and in the One Page at a Time series. Alice and Martha discuss the wonderful pedagogy behind Snape's Potions lesson as well as Seamus's inherent charisma. Plus, find out which unlikely character is most like a bird!Please consider supporting us on Patreon! www.patreon.com/realweirdsisters New episodes are released every Monday and special topics shows are released periodically. Don't forget to subscribe to our show to make sure you never miss an episode!

Nick is joined by John Granger and special guest star Guido in their temporary headquarters as they await the move to Granger Towers. We discuss the revelation that J. K. Rowling has an inherited blood clotting disorder, and speculate that this could be von Willebrand Disease, and discuss what this could mean for a Golden Thread that John first explored more than five years ago. Nick surveys the instances of blood in all her published work, and John identifies a theme that Nick has missed - the Eucharist. Could this be the key to understanding the final narrative arch of the Strike series?Links Discussed in this Episode:The revelation of J. K. Rowling's condition:https://www.hogwartsprofessor.com/j-k-rowling-and-the-roy-phipps-connection/John discusses the Golden Thread on the Reading Writing Rowling Podcast in 2020.https://audioboom.com/posts/7566531-episode-37-troubled-blood-and-the-faerie-queene-strike-5John Granger's book How Harry Cast his Spell exploring the Christian content and meaning in Harry Potter.https://www.amazon.com/How-Harry-Cast-His-Spell/dp/1414321880John's visit to Denmark Street and St Giles-in-the-Fields in 2016.https://web.archive.org/web/20171130161236/https://www.hogwartsprofessor.com/visiting-cormoran-strikes-pub-and-denmark-street-premises-in-london/Victor Turner - Colour Classification in Ndembu Ritual (1966)https://gwern.net/doc/psychology/vision/1966-turner.pdfThe Blood Survey:Harry Potter and the Philosopher's StoneThe word “Blood” appears 33 times.dragon's bloodThe Bloody BaronHarry thought Flint looked as if he had some troll blood in him.One book had a dark stain on it that looked horribly like blood.That's unicorn blood.It put its hand into its pocket and pulled out a blood-red stone.Harry Potter and the Chamber of SecretsThe word “Blood” appears 46 times.not a drop of magical blood in their veins‘Wizard blood is counting for less everywhere –'No Malfoy's worth listenin' ter. Bad blood, that's what it is.‘No one asked your opinion, you filthy little Mudblood,' he spat.who think they're better than everyone else because they're what people call pure-blood.Most wizards these days are half-blood anyway.‘… I smell blood … I SMELL BLOOD!'Harry Potter and the Prisoner of AzkabanThe word “Blood” appears 21 times.‘It all comes down to blood, as I was saying the other day. Bad blood will out. Now, I'm saying nothing against your family, Petunia'Ron and Hermione were standing underneath it, examining a tray of blood-flavoured lollipops.‘BLOOD!' Ron yelled into the stunned silence. ‘HE'S GONE! AND YOU KNOW WHAT WAS ON THE FLOOR?'Harry Potter and the Goblet of FireThe word “Blood” appears 37 times.Now that they had removed their furs, the Durmstrang students were revealed to be wearing robes of a deep, blood red.‘B-blood of the enemy … forcibly taken … you will … resurrect your foe.'I wanted Harry Potter's blood. I wanted the blood of the one who had stripped me of power thirteen years ago, for the lingering protection his mother once gave him, would then reside in my veins, too …Harry Potter and the Order of the PhoenixThe word “Blood” appears 85 times.‘Yoooou!' she howled, her eyes popping at the sight of the man. ‘Blood traitor, abomination, shame of my flesh!'‘Because I hated the whole lot of them: my parents, with their pure-blood mania, convinced that to be a Black made you practically royal‘The pure-blood families are all interrelated,' said Sirius. ‘If you're only going to let your sons and daughters marry pure-bloods your choice is very limited; there are hardly any of us left.‘Terrified? I hope I, Sir Nicholas de Mimsy-Porpington, have never been guilty of cowardice in my life! The noble blood that runs in my veins –'Again and again Harry wrote the words on the parchment in what he soon came to realise was not ink, but his own blood.‘It seems there was some rather unusual kind of poison in that snake's fangs that keeps wounds open. They're sure they'll find an antidote, though; they say they've had much worse cases than mine, and in the meantime I just have to keep taking a Blood-Replenishing Potion every hour.‘While you can still call home the place where your mother's blood dwells, there you cannot be touched or harmed by Voldemort. He shed her blood, but it lives on in you and her sister. Her blood became your refugeHarry Potter and the Half-Blood PrinceThe word “Blood” appears 105 times.‘If I had murdered Harry Potter, the Dark Lord could not have used his blood to regenerate, making him invincible –'Harry had never hated Malfoy more than as he lay there, like an absurd turtle on its back, blood dripping sickeningly into his open mouth.‘My daughter – pure-blooded descendant of Salazar Slytherin – hankering after a filthy, dirt-veined Muggle?'It was as though something large and scaly erupted into life in Harry's stomach, clawing at his insides: hot blood seemed to flood his brainI've learned more from the Half-Blood Prince than Snape or Slughorn have taught me in –'‘Harry, I'd like you to meet Eldred Worple, an old student of mine, author of Blood Brothers: My Life Amongst the Vampires – and, of course, his friend Sanguini.'Blood spurted from Malfoy's face and chest as though he had been slashed with an invisible sword. He staggered backwards and collapsed on to the waterlogged floor with a great splash, his wand falling from his limp right hand.‘Payment?' said Harry. ‘You've got to give the door something?' ‘Yes,' said Dumbledore. ‘Blood, if I am not much mistaken.' ‘Blood?'Harry Potter and the Deathly HallowsThe word “Blood” appears 125 times.As I reveal in chapter sixteen, Ivor Dillonsby claims he had already discovered eight uses of dragon's blood when Dumbledore “borrowed” his papers.'MUDBLOODS and the Dangers They Pose to a Peaceful Pure-Blood Society‘Splinched,' said Hermione, her fingers already busy at Ron's sleeve, where the blood was wettest and darkest.Was it his own blood pulsing through his veins that he could feel, or was it something beating inside the locket, like a tiny metal heart?‘Drop your wands,' she whispered. ‘Drop them, or we'll see exactly how filthy her blood is!'Every drop of magical blood spilled is a loss and a waste.‘Precisely!' said Dumbledore. ‘He took your blood and rebuilt his living body with it! Your blood in his veins, Harry, Lily's protection inside both of you! He tethered you to life while he lives!'Fantastic Beasts and Where to Find ThemThe word “Blood” appears 11 times.The Kappa feeds on human blood but may be persuaded not to harm a person if it is thrown a cucumber with that person's name carved into it.Re'em blood gives the drinker immense strength, though the difficulty in procuring it means that supplies are negligibleSalamander blood has powerful curative and restorative properties.Quidditch Through the AgesThe word “Blood” appears 6 times.The first Bludgers (or ‘Blooders') were, as we have seen, flying rocksThe Tales of Beedle the BardThe word “Blood” appears 5 times.There is not a witch or wizard in existence whose blood has not mingled with that of MugglesCasual VacancyThe word “Blood” appears 97 times.Then pain such as he had never experienced sliced through his brain like a demolition ball. He barely noticed the smarting of his knees as they smacked onto the cold tarmac; his skull was awash with fire and blood; the agony was excruciating beyond endurance, except that endure it he must, for oblivion was still a minute away.All they could get out of her at first was, ‘The Fields, the bloody, bloody Fields …'‘Mrs Weedon's new pills are upsetting her stomach,' said Parminder calmly. ‘So we're doing your bloods today, aren't we?'Sharp, hot pain and the blood came at once; when she had cut herself right up to her elbow she pressed the wad of tissues onto the long wound, making sure nothing leaked onto her nightshirt or the carpet.Some of her self-hatred had oozed out with the blood.Pagford, bloody Pagford. Samantha had never meant to live here.That morning, at breakfast, she had tested her blood sugar with the glucometer for the first time, then taken out the prefilled needle and inserted it into her own belly. It had hurt much more than when deft Parminder did it.Did she find it easier to accept him as a separate individual than if he had been made from her flesh and blood? Her glucose-heavy, tainted blood …The Cuckoo's CallingThe word “Blood” appears 64 times.Her accidental assailant was massive; his height, his general hairiness, coupled with a gently expanding belly, suggested a grizzly bear. One of his eyes was puffy and bruised, the skin just below the eyebrow cut. Congealing blood sat in raised white-edged nail tracks on his left cheek and the right side of his thick neck, revealed by the crumpled open collar of his shirt.Perhaps a knife would plunge between his shoulder blades as he walked through the front door of her flat; perhaps he would walk into the bedroom to discover her corpse, wrists slit, lying in a puddle of congealing blood in front of the fireplace.‘Pushing someone over a balcony's a spur-of-the-moment thing,' said Strike, as though he had felt her inner wince. ‘Hot blood. Blind temper.'When Lucy's lips were pursed she bore a strong resemblance to their Aunt Joan, who was no blood relation to either of them.You're a cold-blooded b*****d, aren't you? No f*****g wonder old Jonny's not keen on you.'Strike, however, knew Charlotte as intimately as a germ that had lingered in his blood for fifteen yearsSergeant Gary Topley lying in the blood-spattered dust of that Afghanistan road, his face unscathed, but with no body below the upper ribs.The SilkwormThe word “Blood” appears 140 times.Message after message, stuck out on the bloody cliffs at Gwithian trying to get reception—Strike had never taken the time to consider, although Polworth, a man of many pithy theories, took the view that such women (‘nervy, overbred') were subconsciously looking for what he called ‘carthorse blood'.‘—and she says he won't let them sell. There was bad blood between Fancourt and Quine.'Strike would have advised any friend to leave and not look back, but he had come to see her like a virus in his blood that he doubted he would ever eradicate‘So much for love being a mirage and a chimera,' sighed Mrs Ellacott as she tossed down her pen. ‘This is no good. I wanted blood and guts, Michael. Blood and guts.'Career of EvilThe word “Blood” appears 115 times.He had not managed to scrub off all her blood. A dark line like a parenthesis lay under the middle fingernail of his left hand.He was good at reading people. He had read and charmed the girl who had died yesterday among the blood-soaked peach towels.“He doesn't like talking about personal stuff. Blood out of a stone.”On a high metal table sat a pillow in a plastic evidence bag; it was covered in dark brown bloodstains. A cardboard box next to it contained bottles of spirits. Where there was bloodshed, there was always alcohol.Strike remembered the wide patch of blood on the sheets, the excoriated skin on her wrist where Rhona had tried to free herself.Nevertheless, those long hours of driving through the darkness when he had known an encounter with the police might be fatal, when he had feared a request to turn out his pockets or a shrewd-eyed passenger noticing dried blood on him had taught him a powerful lesson.He was wearing a yellow T-shirt and on his right forearm was the rose tattoo, which had undergone a modification: a dagger now ran through it, and drops of blood fell out of the flower towards the wrist.If they'd been five minutes later she'd've been a goner. It took two blood transfusions to keep her alive.Lethal WhiteThe word “Blood” appears 143 times.He had been left with a deep dislike of being driven by anybody else and, to this day, with dreams of blood and agony that sometimes woke him, bathed in sweat.She could imagine Raphael bloody at the steering wheel, and the broken figure of the young mother on the road, and the police cars and the incident tape and the gawpers in passing cars.“Last night, when he was stoned. He said he knew a government minister who had blood on his hands.”“Would you mind waiting outside the curtain? We need to take bloods, change his drips and his catheter.”Strike could taste blood, but, from what he could see, the splintered and torn remnants of Jimmy's placard had been scattered by the mêlée.There was a piece of thick cream writing paper headed with a red Tudor rose, like a drop of blood, and the printed address of the house in which Robin stood.The old knife wound on her arm had been gaping open and it was the trail of her spurting blood that her pursuers were following, and she knew she would never make it to the place where Strike was waiting for the bag of bugs . . .‘She come into the yard, seen what had happened, ran towards Mr Chiswell, grabbed the hammer and just swung for him. Blood everywhere. It was horrible,'Troubled BloodThe word “Blood” appears 171 times.“Yeah, well, blood and soil's never been my—”She'd heard stories that Ilsa gave titles like cheap thrillers: the Night of the Bread Knife, the Incident of the Black Lace Dress and the Blood-Stained Note.She believed, I think, like Suhrawardy, that ‘bloodshed and disorder are not necessarily evil in themselves, if resorted to for a noble cause.'”And even in the seventies, before DNA testing, the police did pretty well with fingerprints, blood groups and so forth.“Anyway, one of the things she told Lawson was that she'd sponged blood off the spare-room carpet the day Margot disappeared.“According to Roy, the age difference and the blood relationship ought to have constituted a total prohibition on the relationship in the minds of all decent people. But as we know, he managed to overcome those qualms seven years later.In the second week of November, Joan's chemotherapy caused her white blood cell count to plummet dangerously, and she was admitted to hospital.She'd only once in her life had to face the possibility that she might be pregnant, and could still remember the relief that had flooded her when it became clear that she wasn't, and wouldn't have to face still more contact with strangers, and another intimate procedure, more blood, more pain.“But there was something bloodless about the man. Not wet exactly, but—” Oonagh gave a sudden laugh. “‘Bloodless'—you'll know about his bleeding problem?”The demon he “saw” was carrying a cup of blood and a sword.‘She – never seemed – to remember – that I couldn't – protect her – couldn't – do anything – if somebody tried – to hurt – because I'm a useless – bleeder … useless … bloody … bleeder … 'A few pages inside was a brown smear. Strike halted the cascade of pages to examine it more closely. It was, he suspected, dried blood, and had been wiped across a few lines of writing.This I will say more, to wit, that those who walk in their sleep, do, by no other guide than the spirit of the blood, that is, of the outward man, walk up and down, perform business, climb walls and manage things that are otherwise impossible to those that are awake.She'd taken the full force of Strike's elbow between her eyebrows, and she realised her nose was bleeding only when she accidentally sprayed blood onto the kind American's white shirt front.‘It – was – a – f*****g – joke,' said Morris, examining the blood smeared on his hands. ‘I only meant to make you jump – f**k's sake—'The Ink Black HeartThe word “Blood” appears 214 times.There was bad blood between Strike and Mitch Patterson, the boss of the agency in question, which dated back to the time Patterson had put Strike himself under surveillance.‘Thanks – I ripped off a nail opening the last one. Yeah, so she was banging on about blood diamonds, and I…'Having explained the Christian symbolism of the pelican, which was feeding her chicks with her own blood, Groomer wondered aloud whether Legs was ready for a coffee‘Second letter of the alphabet, eighth letter: BH. Stands for blood and honour. Blood and Honour are a neo-Nazi skinhead group.'Might still be a bit of Edie's blood on the grass. You could frame it. Sell it on eBay.Vilepechora: I fkn love a redhead. Proper Viking bloodStrike parked, then used the old man's handkerchief and his own saliva to remove from his face all traces of blood, of which there was a surprising amount.Red Soles lay where he'd been deposited on the platform, blood trickling from his inner ear.They fort there was a vampire in the real cemetery, in the seventies. Edie fort it was corny, 'avin' a vampire, but I drew 'im so she could see what I was finking. I wanted 'im to be inept, like, tryna kill tourists but never gettin' enough blood to live on, so 'e was, like, weak an' feeble…'‘Julius Evola. Far-right philosopher. Ludicrous racial theories. A rather determinedly eccentric classmate of mine at Radley was partial to him. Used to carry The Myth of the Blood around and read it ostentatiously at meal times.It was impossible to know whether Ross had turned pale, because the man had always looked as though antifreeze ran in his veins rather than blood, but he'd certainly become unnaturally still.Robin stamped hard on his bare foot before both slipped in another puddle of Inigo's blood.As the door shuddered, Robin saw, by the dim glow from a skylight, Katya slumped on the floor beside the bath, blood all over the hands she was pressing against her stomach.The Running GraveThe word “Blood” appears 194 times.It's important to say that my mother – I was raised to call her Louise, because the UHC forbids naming blood relationships – isn't stupid.It'll have been used for chopping wood, but Oisin was convinced it had blood on it. We couldn't get it out, though. We couldn't reach.I don't know what's normal for a birth but she seemed to lose a huge amount of blood. I was present when the baby was actually born because one of the birthing team couldn't cope any more and I volunteered to take her place.Strike's imagination insisted on showing him a vivid picture of Charlotte submerged in her own blood, her black hair floating on the clotted surface.There was a puddle of blood seeping from under one of the toilet cubicle doors. She could see Lin's bloodstained legs, which weren't moving.They committed nine murders in all, one of them of a pregnant actress, and those young women were right in the thick of the action, ignoring the victims' pleas for mercy, dipping their fingers in the victims' blood to scrawl – Jesus,' said Strike, with a startled laugh, as he remembered a detail he'd forgotten, ‘they wrote “pigs” on the wall as well. In blood.'The Hallmarked ManThe word “Blood” appears 246 times.Some might have considered her flat tone insensitive, given Charlotte's recent death in a blood-filled bathtub, but as Strike was more than happy to dispense with prurient questions or faux sympathyThe body was blood group A positive – that's the same.‘The splash patterns from the blood were un-fakeable, according to forensics. There was also a partial footprint that had clearly been made while the blood was still liquid.'The back wall broke the monotony of the sea of silver, because it displayed many antique aprons and sashes embroidered in gold, and Robin's eye lingered on an apron embroidered with a bloody severed head, held up by a single hand.‘Yeah, somefing like… an' 'e dropped 'is doob tube, remember, Daz? An' 'e told you it was a f****n' blood sample, like you was gonna nick it off 'im.'Previously a Conservative MP, he now headed various charitable and political organisations and committees, was ever-ready with a quote for the papers, sprinkled his conversation with Latin tags and capitalised to the full on the English public's weakness for a toff who seemed ready to laugh at himself, having a fondness for appearing on political quiz shows, where he played to the hilt the part of genial, bumbling blue-blood.Blood must've started pooling in the lower part of the body before they started to mutilate it. Maybe that was deliberate. Maybe they didn't want blood seeping out under the vault door.'As Strike watched, life and blood started to drain from the brindle, its legs twitching ever more feebly as blood flooded from its jugular.Robin took the turn into the road at speed, then looked sideways at Strike, one of whose hands was pressed to his inner thigh, blood seeping through his fingers.The bodies of Jim Todd and a woman Strike assumed to be his mother, Nancy, were lying on the dirty carpet in a foul miasma encouraged by the gas fire that continued to blaze. Todd, who was fully dressed, had been stabbed multiple times. His now black blood had soaked his shirt and the floor beneath himBlood now gushing from his head wound, Strike succeeded in grabbing the wrist of Griffiths' knife-holding hand, then slammed it down on the rough concrete floor,He could feel a weird coldness, as though flesh that had never been exposed to fresh air was meeting it for the first time, and this contrasted unpleasantly with the continuing flow of warm blood.Possibly combining heavy blood loss and neat whisky hadn't been the very best idea, Strike was prepared to concede that now, but he had to keep talking, because he wanted the man to know he knew.The IckabogThe word “Blood” appears 11 times.‘If Beamish was half-eaten, why wasn't there more blood?' asked the second.soldiers who'd been sent back to the marsh to find out what happened to Private Nobby Buttons had discovered nothing but his bloodstained shoes, a single horseshoe, and a few well-gnawed bones.Finally, the same man cut off the head of one of the hens and made sure plenty of blood and feathers was spread around, before breaking down the side of the coop to allow the rest of the chickens to escape.In hundreds, Ickabogs were slain, Our blood poured on the land like rain, Our ancestors like trees were felled And still men came to fight us.The Christmas PigThe word “Blood” appears 2 times.They all seemed to be bits of humans. Some were mouths: one was loudly chewing gum and others smoking stinking cigarettes, which made the glowing red dots and the nasty smell. There were noses, ears, a single finger, its nail chewed to a bloody stub, several oozing spots which were so disgusting Jack could barely look at them, and a couple of fists, which were pounding the ground in a menacing fashion as though they couldn't wait to start hitting someone.The Cursed ChildThe word “Blood” appears 22 times.ALBUS (with power and strength) No, you need to listen to me, you said it yourself – how much blood is on my father's hands. Let me help you change that. Let me help correct one of his mistakes. Trust me.POLLY CHAPMAN The Blood Ball of course – who you – the Scorpion King, are taking to the Blood Ball.POLLY CHAPMAN Mudbloods of course. In the dungeons. Your idea, wasn't it? What's going on with you? Oh Potter, I've got blood on my shoes again . . .DRACO We were capable of having children, but Astoria was frail. A blood malediction, a serious one. An ancestor was cursed . . . it showed up in her. You know how these things can resurface after generations . . .Fantastic Beasts (Screenplay)The word “Blood” appears 2 times.Fantastic Beasts and the Crimes of GrindelwaldThe word “Blood” appears 20 times.A baby Chupacabra—part lizard, part homunculus, a blood-sucking creature of the Americas—is chained to GRINDELWALD'S chair.SKENDER Once trapped in the jungles of Indonesia, she is the carrier of a blood curse. Such Underbeings are destined, through the course of their lives, to turn permanently into beasts.We see TEENAGE DUMBLEDORE and TEENAGE GRINDELWALD facing each other in a barn. Both score their palms with their wands. Now bleeding, they interlace their hands . . .DUMBLEDORE turns his head away, fighting the impulse to cover the glass again. Bracing himself, he looks up.From their bloody palms rise two glowing drops of blood, which mingle and merge to create one. A metal shape begins to form around the droplet, becoming more defined and intricate. It is GRINDELWALD'S vial.NEWT It's a blood pact, isn't it? You swore not to fight each other.Fantastic Beasts and the Secrets of DumbledoreDumbledore stares at him, then slowly brings a hand into view and reveals: the BLOOD TROTH. As he cradles it, its chain slowly slithers between Dumbledore's fingers, as if alive.Theseus nods, eyeing the troth, watching as the DROPLETS OF BLOOD circle one another like weights in a clock.The blood troth flashes red and flies free, caroming off the floor and to the wall. As he draws his wand, taking aim, the troth's chain, still tethered to his arm, constricts, burrowing deep into his flesh.CREDENCE I'm a Dumbledore. You abandoned me. The same blood that runs my veins runs yours. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit hogwartsprofessor.substack.com/subscribe

Send us a textIn this episode, we discuss the trio's journey through the trap door in our version of the Harry Potter TV show. Enjoy!Topics/Summary:·      Listen to episode 315, QuizMaster: Trap Door Edition here!·      1:19 Challenge question and recap of Tea Leaves S1 E6.·      7:56 The first shots of the episode show us the quiet stillness of the castle at night. The moon is shining, and there is an eerie air about the corridors. The trio approaches the door and goes through to Fluffy's chamber. There should be a harp playing and a flute, and they jump through. Fluffy shouldn't wake up like he does in the films to preserve this eerie air.·      12:50 The devil snare. It should remain largely the same because a lot of important details in terms of character dynamics are revealed. But when they all escape there should be a more magical escape. Perhaps all the devil snare recedes in a flash and they are left in a room with a door to the key room.·      18:05 The flying keys. They should stay pretty much the same. The balance of this whole trapdoor sequence is struck already, and we shouldn't mess with that too much.·      19:51 The chess match. This is one of the most intense parts of the trap door adventure. The pieces are smashed to pieces when they are taken, and the trio are standing in the face of these blocks of rock are slowly moving towards them to find their next victim. Ron sees the moves and sacrifices himself so Harry and Hermione might go on. Perhaps a sacrifice like that is required by the room for them to move on.·      24:52 The potions riddle. Hermione is an absolute boss in this scene because she shows us all how critically she can think. Those skills come in handy for sure later on in the story.·      28:21 The final scene. Quirrell turns around and Harry is shocked that it isn't Snape. Most of this scene should stay the same, but there's one moment I want to see. When Voldemort offers Harry power, immortality, and his family back, I want to see Harry's reaction. The fact that Harry doesn't react to power and immortality, but he considers his family back for just a moment is super important. That one moment shows us more about Harry than we've learned in the rest of the book for that.Having anything you want to hear or say? Click here for a voice submission or here for text. ThePotterDiscussion@gmail.comthepotterdiscussion.comNox

Join Snapecentric, dirty_muggle, masao, and SerenaEW as we celebrate Snape's birthday! There's a variety of Snape stories, by Truliarose, dirty_muggle, CypressWand, starcrossedgirl, Asenora and Threadbear, read by Truliarose, dirty_muggle, snape_snail_tape, SerenaEW, Faithless_3105, and mangotart_reads. Things go NSFW at about 1:57:00Art: Fan Arts ko-fi tumblrMusic:  Dark Nature by Bruno Magic from PixabayVisit our⁠⁠ ⁠⁠Additional Reading⁠⁠⁠⁠ page for links and more!

This week, it's a long-overdue return to our favorite foursome as we cover All the Young Dudes chapters 88-90. Things are getting tense, teenagers are really teenagering, and the Snape feud is reaching new levels of intensity. Also, we're talking about the Venn diagram that is a circle of how Remus, Harry, and Amanda deal with people making a fuss over them, poor little Christopher and his pining, and Kev is having ‘Nam flashbacks. Support the showSupport FFH on Patreon: patreon.com/thefoxandthefoxhoundFollow us!IG: @thefoxandthefoxhoundTikTok: @thefoxandthefoxhound

Send us a textIn this episode, we test our knowledge on the trio's journey through the trap door. Enjoy!Topics/Summary:·      2:04 Warm Up Round·      4:03 Question #1: How do the trio get around Fluffy? What instrument do they play?·      10:10 Question #2: What spell does Hermione use to get past the devil snare?·      14:50 Question #3: What position does Ron play in the chess game?·      18:26 Question #4: How many potions does Snape leave? How many are poison?·      23:54 Question #5: What does Voldemort ask Harry?·      28:22 Question #6: Why does Harry, not Quirrell, get the stone?·      30:05 Question #7: True or false; the whole thing was a complete secret and none of the students found out.·      32:07 Challenge QuestionHaving anything you want to hear or say? Click here for a voice submission or here for text. ThePotterDiscussion@gmail.comthepotterdiscussion.comNox

Send us a textIn this episode, we are discussing  Harry Potter and the Prisoner of Azkaban Chapter 22. We have renamed the chapter "Snape gets mad, and Lupin quits, The End"Support the show and get some cool bonuses (Including videos!)  (https://www.patreon.com/PotterChat)Follow us on Facebook (https://www.facebook.com/PotterChatPodcast)Join the discussion in our Facebook group (https://www.facebook.com/groups/246834503246058)Follow us on Instagram (https://www.instagram.com/potterchatpodcast)Follow us on Twitter (https://twitter.com/potter_podcast)Support the show

Why do some people seem to hate you no matter what you do, even when you have not done anything wrong? Dr. K calls this displaced hatred, anger that cannot be aimed at the real source, so it gets redirected onto a safer target. He uses Snape's unfair treatment of Harry as a clean example of how this happens when love, loss, and betrayal collide. From there, he brings it into real life: family dynamics, workplaces, and even online anger. Once you can spot displaced hatred, you stop wasting energy trying to win someone over in an unwinnable situation, and you can start tracing your own persistent anger back to the person or wound you “aren't allowed” to be mad at. Topics Included -What displaced hatred is, and why it feels so unfair to the target -Snape, Lily, James, and Harry as a case study in redirected anger -Why the mind struggles to hold love and hate toward the same person -A therapy insight: the parent you do not talk about can hold the real pain -How “good parent” narratives can hide resentment about lack of protection -Common real world pattern: coworker anger that is actually about the boss -Why killing someone with kindness often fails when the issue is not you -How displaced hatred keeps you taking responsibility for someone else's problem-The role of self hatred, depression, and why anger can get redirected outward HG Coaching : https://bit.ly/46bIkdo Dr. K's Guide to Mental Health: https://bit.ly/44z3Szt HG Memberships : https://bit.ly/3TNoMVf Products & Services : https://bit.ly/44kz7x0 HealthyGamer.GG: https://bit.ly/3ZOopgQ Learn more about your ad choices. Visit megaphone.fm/adchoices

On Episode 484 we discuss...→ The dynamics between adult characters in the series reveal their immaturity→ Snape and Sirius serve as foils to each other throughout the series→ Hermione's intelligence is often undermined by adult characters→ The characters often revert to their childhood selves in moments of trauma→ Dementors symbolize the weight of despair and obsession→ The Complexity of Protection→ Harry's Perceptiveness and the Outlandish Truth→ The Complexity of Peter PettigrewBecome a supporter of this podcast: https://www.spreaker.com/podcast/alohomora-the-original-harry-potter-book-club--5016402/support.

This week we make a few end-of-year predictions for what 2026 will hold in store for Harry Potter fans, and open up the MuggleMail bag further than ever, as we read recent comments from YouTube and Spotify in addition to Discord, voicemails and e-mail! Join Andrew, Eric, Micah and Laura for our final episode of 2025! Looking ahead: what news will we get about a Hogwarts Legacy sequel? How about the HBO TV series? Will more series be green lit? Andrew leads the group in making unhinged predictions including genderbent books and a line of adults-only official merchandise. Our own 2026 plans for MuggleCast include content that looks ahead as well as back, including more talks on the TV show and classic components of HP fandom history. Voicemails sent in include a Hermione Granger impression, and ask the question, "how do children learn Voldemort's name?" Was Arthur Weasley's originally-planned death hinted at in the text of Book 5 and before? Spotify listeners want to know: is Snape projecting? What is the general skill level of your average every day wizard? And will Micah tell more dad jokes? Is Severus Snape a good teacher? What about his old Potions book? Why doesn't Dumbledore ever tell Harry exactly how to destroy the Horcruxes? And, does Hermione belong in Ravenclaw? Additionally, folks tell us their feelings on the Full Cast Harry Potter Audiobooks as well as the Tonks and Lupin romantic subplot. Our Lynx Line segment asks our most dedicated listeners for recommendations of books they've read this year and enjoyed. See the full list of suggestions here! Bonus MuggleCast, available over on our Patreon, will have the hosts discussing their behind-the-scenes stories of contributing to MuggleNet.com MuggleCast will return January 12, 2026! Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us a textIn this episode, we discuss Norbert the Norwegian Ridgeback and our first encounter in the Forbidden Forest in our version of the Harry Potter TV show. Enjoy!Topics/Summary:·      1:36 Quick recap, and Hagrid Spilling the beans! If we learn all these new things about Fluffy in a more natural manner, it shows us just how much that information means. Also, if the trio knows it, Snape might too.·      9:43 Norbert is born. Norbert plays a small role in the story, but still he has a lasting impact. We should have the chance to see why Norbert means so much to Hagrid. Harry and Hermione have to bring Norbert to astronomy tower to be taken away, but they are caught. Off to the forest!·      19:34 Off to the Forest! This is our first encounter with Voldemort and an introduction into the dangerous life of Hogwarts.Having anything you want to hear or say? Click here for a voice submission or here for text. ThePotterDiscussion@gmail.comthepotterdiscussion.comNox

Med kapitel 25 og 26 nærmer vi os slutningen af Halvblodsprinsen, da Dumbledore og Harry tager på en skæbnesvanger Horcruxjagt i grotten. Det er en følelsesmæssigt ladet episode, særligt for Nanna - og så taler vi selvfølgelig også om Snape's forældre, hans involvering i mordet på Harry's forældre, og hvorvidt Dumbledore oplever magi (og verden i det hele taget) på en anden måde en Harry. 

In this explainer episode, we've asked Dr Katie Snape, principal clinician at Genomics England, cancer geneticist, and specialist in inherited cancer, to explain how genomics can help us understand cancer. You can also find a series of short videos explaining some of the common terms you might encounter about genomics on our YouTube channel. If you've got any questions, or have any other topics you'd like us to explain, let us know on podcast@genomicsengland.co.uk. You can download the transcript or read it below. Flo: How can genomics help us understand cancer?   I'm Florence Cornish, and today I'm joined with Katie Snape, who is Principal Clinician here at Genomics England, lead Consultant for Cancer Genetics at the Southwest Thames Centre for Genomics, and Chair of UK Cancer Genetics Group. So Katie, it's probably safe to say that everyone listening will have heard the word cancer before. Lots of people may have even been directly affected by it or know someone who has it or who has had it, and I think the term can feel quite scary sometimes and intimidating to understand. So, it might be good if you could explain what we actually mean when we say the word cancer.   Katie: Thanks, Florence. So, our bodies are made up of millions of building blocks called cells. Each of these cells contains an instruction manual, and our bodies read this to build a human and keep our bodies working and growing over our lifetimes. So, this human instruction manual is our genetic information, and it's called the human genome. Throughout our lifetime, our cells will continue to divide and grow to make more cells when we need them. And this means that our genetic information has to contain the right instructions, which tell the cells to divide when we need new cells, like making new skin cells, for example as our old skin cells die, but they also need to stop dividing when we have enough new cells and we don't need anymore. And this process of growing but stopping when we don't need anymore cells, keeps our bodies healthy and functioning as they should do. However, if the instructions for making new cells goes wrong and we don't stop making new cells when we're supposed to, then these cells can grow out of control, and they can start spreading and damaging other parts of our body. And this is basically what cancer is. It's an uncontrolled growth of cells which don't stop when they're supposed to, and they grow and spread and damage other tissues in our body. Florence: So, you mentioned there that cancer can arise when the instructions in our cells go wrong. Could you talk a little bit more about this? How does it lead to cancer? Katie: Yeah. So the instructions that control how our cells should grow and then stop growing are usually called cancer genes. So our body reads these instructions a bit like we might read an instruction manual to perform a task. So if we imagine that one of these important cancer genes that has a spelling mistake, which means the body can't read it properly, then those cells won't follow the right instructions to grow and then stop growing like they should. So if our cells lose the ability to read these important instructions due to this type of spelling mistake, then that's when a cancer can develop. As these spelling mistakes happen in cancer genes, we call them genetic alterations or genetic variants. Florence: And so, when you're in the clinic seeing somebody who has cancer, what kinds of genomic tests can they have to help us find out a little bit more about it? Katie: So the genetic alterations that can cause cancer can happen in different cells. So that's why cancer can affect many different parts of the body. If a genetic alteration happens in a breast cell, then a breast cancer might develop. If the alteration happens in a skin cell, then a skin cancer could develop. We can take a sample from the cancer. This is often known as a biopsy, and then we can use this sample to extract the genetic information to read the instructions in the cancer cells, and when we do this, we are looking for spelling mistakes in the important cancer genes, which might of course, those cells to grow out of control. We can also look for patterns of alterations in the cells, which might tell us the processes that led to those genetic alterations occurring. For example, we can look at patterns of damage in the genetic information caused by cigarette smoke, or sunlight, or problems because the cell has lost its ability to mend and repair its genetic information. And we can also count the number of different alterations in the cancer cell, which might tell us how different that cancer cell is from our normal cells, and that can be important because we might be able to use medications to get our immune system to attack the cancer cells. So where we see genetic alterations in a cancer cell, we call them acquired or somatic alterations because we weren't born with them, but they've happened in a cell in our body at a later stage, and they've caused those cells to become uncontrollable and to keep growing. Sometimes people can be born with a genetic alteration in a cancer gene that significantly increases the chance of them developing cancer in their lifetime. This type of genetic alteration can be inherited, and so these changes can be shared by relatives. If we see more cancer in a family than we would expect by chance, or unusually young cancers or patterns of cancer, or there are other signs that a cancer patient might have an inherited cancer gene causing their cancer, then we can offer a test to check for this as well. Florence: And so, when we do these tests, what are we looking for specifically? What is it that we're trying to find out about a person's cancer that could help us to treat it as effectively as possible? Katie: So all of these genetic tests are helping us understand why a cancer has developed and what are the underlying changes that cause the cells to grow out of control. If we understand why the cancer developed, we can choose medications to try and treat the cancer and these specifically target the underlying problems in the cell, and hopefully attack the cancer cells, but not the normal cells in the body. We call this precision or personalised medicine. Many newer cancer drugs specifically target the changes that have occurred in the cancer cells as part of this process for becoming cancer, and they kill those that carry specific genetic changes which have caused those cells to grow uncontrollably. Florence: I wanted to ask you now about inherited cancer risk. So by this we mean if a parent has a change in one of their genes that increases their risk of developing cancer, there's a possibility that they can then pass this gene along to their children. Is there anything we can do to manage these inherited risks? Katie: If a person has an inherited change, increasing cancer risk, we can offer them programs to help reduce that risk. There are different things that we might offer them. So, for example, for some conditions we have preventative medication. There is a condition called Lynch syndrome, which is due to a change in some cancer genes, and people who have Lynch syndrome have a high chance of developing bowel and womb cancers, amongst others. For people with Lynch syndrome, they can take a daily low dose aspirin, and this reduces their chance of developing a bowel cancer by about a half. Or in other cases, we can offer extra screening and that will allow us to catch any cancers that do occur at an earlier stage when they're more likely to be more effectively treated. So for example, if someone has a high risk of breast cancer, we could offer them extra and more frequent screening of their breast. Another option is we could offer risk reducing surgery. So, for example, if someone had a higher chance of developing ovarian cancer after the age of 50, we could offer removal of the tubes and ovaries as their chance of cancer starts to increase, and that would significantly reduce their risk of developing cancer in the future.  Florence: And, working in this space, you and I know that research groups are working all the time to try and better understand cancer and how we might be able to treat it more effectively. Could you tell me about how genomics in particular is helping to advance the detection and treatment of cancer?  Katie: Genomics is helping develop both our understanding of how and why cancer develops, and as well as that, it's also helping us find new cancer treatments all the time.   There are already many drugs that are available to cancer patients that specifically target the genetic changes found in their cancer. In addition to that, there are many clinical trials now for cancer patients, which use the information from genomic sequencing to help guide new research into better treatments based on the genetic alterations in the cancer cell.  We are increasingly using genetic testing to identify more at-risk people with inherited changes in the population as well, so that we can make sure if they have a higher chance of developing cancer in their lifetime, that they get the best prevention and screening programs available. our understanding of genomics is really impacting both our understanding of what causes cancer, how we treat it, and how we can prevent it as well.  Florence: So, I think we'll finish there. Katie, it's been so great to talk to you and to learn more about why genomics is proving to be so important in helping us to understand cancer.   If listeners want to hear more, explain episodes like this, you can find them on our website@www.genomicsengland.co.uk or wherever you get your podcasts. Thank you for listening. 

This week, Casper and Vanessa explore the theme of Imagination in Chapter 33 of Harry Potter and the Deathly Hallows! They discuss Petunia's childhood, Snape & Lily, and Harry's connection to Voldemort! Throughout the episode we consider the question: under what types of conditions are we able to image best?Thank you to Sam for this week's voicemail! Next week we're reading Chapter 34, The Forest Again, through the theme of Impossibility.Harry Potter and the Sacred Text is a Not Sorry ProductionFind us at our website | Follow us on Instagram--It's two sickles to join S.P.E.W., and only five dollars to join our Patreon for extra content every week! Please consider helping us fill our Gringotts vault so we can continue to make this show. Hosted on Acast. See acast.com/privacy for more information.

Help MuggleCast grow! It's the holiday season and you can get 20% off your Patreon membership at Patreon.com/MuggleCast. Just use code HOLIDAY at checkout and receive a slew of great benefits instantly! And don't forget, Patreon memberships can be gifted! Get cozy this winter with a MuggleCast hoodie, Laura's pants, or a long-sleeve tee! And if you're Down Under, stay cool this summer with a short sleeve tee or crop top. Get 20% off all official merch at MuggleCastMerch.com when using code HOLIDAY at checkout! Pick up overstock items from years past at MuggleMillennial.Etsy.com! This week, explore the various teaching competencies of Hogwarts staff, and join the MuggleCasters as Harry dusts off an old potions book to find a cramped surprise within! With Slug Club member Audrey joining the discussion, it's a can't-miss episode covering the ethics of letting someone else do all the work. Welcome to the show Slug Club member Audrey! Chapter-by-Chapter continues with Half-Blood Prince, Chapter 9: The Half-Blood Prince The MuggleCast Pensieve segment highlights our last discussion of this chapter back on MuggleCast #389! How does McGonagall's attentiveness, which makes her a great teacher, compare with Slughorn's incentivizing students to achieve their best work yet? Do less successful teachers (cough, Trelawney, cough, Snape) have something to learn from other teaching styles? Does the arrangement between Firenze and Trelawney to both teach Divination make sense? Was Snape really going to attack Harry? (All signs point to yes!) Crackpot Theory: Is Snape only being as awful as ever to Harry because Malfoy, now a Death Eater, is watching? Is Horace Slughorn... a good teacher?! His first lesson seems amazing. What would he be like with younger students? What are the pros and cons of Harry coming clean, and is what he chooses to do ethical? Is Hermione or Ginny closer to being right? Connections between this chapter and books 2 and 1 are plentiful! We discuss all the ones we found. MVP: Top sassy Harry lines that AREN'T “There's no need to call me sir, professor.” Lynx Line: Have you ever had a school subject that you loved be taught by someone that you didn't? How did it go? Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is sponsored by BetterHelp - go to http://betterhelp.com/super to get 10% off your first month. Was Snape's love for Lily literally hidden by a Fidelius Charm? Today we dive into one of the wildest (and most convincing!) Harry Potter theories ever. In today's episode, Ben explores a massive revelation about Severus Snape, Albus Dumbledore, and the Fidelius Charm — and how one magically concealed secret may have shaped the entire wizarding war. Why did nobody — not the Marauders, not McGonagall, not Voldemort himself — ever put together Snape's obvious love for Lily?  #HarryPotter #SuperCarlinBrothers  Written by: J & Ben Carlin Edited by: Isybelle Christley

This week, Casper and Vanessa explore the theme of Humility in Chapter 32 of Harry Potter and the Deathly Hallows! They discuss Snape's final words, Hermione's plea, and Luna's words of encouragement! Throughout the episode we consider the question: when is humility a hindrance and when is it necessary?Thank you to Robyn for this week's voicemail! Next week we're reading Chapter 33, The Prince's Tale, through the theme of Imagination.Harry Potter and the Sacred Text is a Not Sorry ProductionFind us at our website | Follow us on Instagram--It's two sickles to join S.P.E.W., and only five dollars to join our Patreon for extra content every week! Please consider helping us fill our Gringotts vault so we can continue to make this show. Hosted on Acast. See acast.com/privacy for more information.

Send us a textIn this episode, we discuss the first classes at Hogwarts to Harry's first Christmas with his new magical life in our version of the Harry Potter TV show. Enjoy!Topics/Summary:·      2:06 Quick recap, and classes begin! Classes are the life of the castle and the core of what it means to be a student at Hogwarts. I want to have a more in-depth view of a class at Hogwarts so we can better understand the everyday life of the students.·      9:56 First flying lesson. This is a pivotal scene. Quidditch symbolizes the good of the castle and the things that Harry is fighting for. It is his safe ground at Hogwarts and the thing he can always rely on. When his Firebolt spins out of the sidecar during his escape from 4 Privet Drive in the Deathly Hallows, it marks the end of his childhood and beginning of his true fight.·      17:58 There's a troll in the dungeons! With this sequence we see the bond of the trio. Harry and Ron save Hermione from the troll, and Hermione takes the blame from the professors. We also see the lengths Voldemort's followers are willing to go to defend him which sets up the following he will later gain.·      25:23 The Midnight Duel and the first quidditch match. These two things are related because they set up Snape. We think he's no good from the beginning, and seeing Fluffy for the first time and then seeing Snape curse Harry's broom is pretty damning evidence.·      28:30 Christmas. This will finish out the episode. Harry and Ron have their first Christmas together and Harry gets the invisibility cloak which he will use for many years to come. We see the mirror of Erised, which will act as the final shot. Having anything you want to hear or say? Click here for a voice submission or here for text. ThePotterDiscussion@gmail.comthepotterdiscussion.comNox

Help MuggleCast grow! It's the holiday season and you can get 20% off your Patreon membership at Patreon.com/MuggleCast. Just use code HOLIDAY at checkout and receive a slew of great benefits instantly! And don't forget, Patreon memberships can be gifted! Get cozy this winter with a MuggleCast hoodie, Laura's pants, or a long-sleeve tee! And if you're Down Under, stay cool this summer with a short sleeve tee or crop top. Get 20% off all official merch at MuggleCastMerch.com when using code HOLIDAY at checkout! Pick up overstock items from years past at MuggleMillennial.Etsy.com! This week, make sure you're on time for the start of term feast, lest you want to be berated by your (least) favorite Hogwarts professor! Join Andrew, Eric, Laura and Micah for an angst-ridden stroll up to the castle. TV Show Update: Daniel Radcliffe pens letter to  Dominic McLaughlin Chapter-by-Chapter continues with Half-Blood Prince, Chapter 8: Snape Victorious. The MuggleCast Pensieve segment highlights our last discussion of this chapter back on MuggleCast #388! What if… no one had discovered Harry was missing before the train left Hogsmeade? Why doesn't Hogwarts staff or the conductor perform a sweep? Micah doesn't see an issue, but others on the panel see a big nightmare. Why isn't Dumbledore searching for Harry the moment he doesn't show up? What causes one's Patronus to change? The hosts retake the quiz! Oh hell, Doe! Snape is in no position to criticize someone else's Patronus! Do we think Snape is projecting his bitterness toward James onto Harry? Could Snape's taunting be an attempt to get Harry to reveal what happened? We connect Harry's "grand entrance" back to Chamber of Secrets Slughorn is the new... POTIONS MASTER?!? Which means... Snape is the new... Defense Against The Darks Arts Professor?!?! NOOOOO! MVP: Who wore their injury better? Harry or Dumbledore? Lynx Line: If Snape had never met Lily, what form do you think his Patronus would take? Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, we're bringing you another of Amanda's Fave Chaps (rebranding to Salty Chaps pending) and revisiting the beloved “Moony, Wormtail, Padfoot, and Prongs” from Prisoner of Azkaban. We're drawing all kinds of parallels to our ATYD journey, working through Kev's renewed shock about the prank that almost killed Snape, and somehow talking a LOT about Dumbledore in a chapter in which he doesn't even appear. Support the showSupport FFH on Patreon: patreon.com/thefoxandthefoxhoundFollow us!IG: @thefoxandthefoxhoundTikTok: @thefoxandthefoxhound

Ok, here us out. We got on a roll and we're doing more Harry Potter theories. And what are McGonagall & Snape up to?⚡️

Julie returns to provide her signature incendiary commentary! Elizabeth also joins the episode to continue her first read of Cursed Child. We discuss alternate versions of Hermione & Ron, Umbridge's power-up, and Snape's redemption. Julie wraps the episode by giving a summary of her thoughts on Cursed Child as a whole up to this point so stick around til the end!

Help MuggleCast grow! Join us at Patreon.com/mugglecast, and receive a slew of great benefits instantly, including bonus episodes, recording studio access, ad-free episodes, and much more! Listeners can browse our official merch at MuggleCastMerch.com and pick up overstock items from years past at MuggleMillennial.Etsy.com, now more affordable than ever! This week, don't get distracted by the WonderWitch product line; a love potion is captivating but Draco Malfoy sneaking off is gonna have longer-lasting implications! Join Micah, Eric and Julian as they wind their way through the twists and turns of an otherwise dark and desolate Diagon Alley. Welcome back Professor Julian Wamble, PhD - host of Critical Magic Theory podcast! We first spoke with Julian on MuggleCast 619 (Professor Trelawney's Prediction) and then recently on MuggleCast 708 (Snape's Worst Memory). You can also find him on Instagram and TikTok!  Chapter-by-Chapter continues with Half-Blood Prince Chapter 6: Draco's Detour The MuggleCast Pensieve segment, highlighting our last discussion of this chapter on MuggleCast #384, features a deep analysis of U-No-Poo! The Ice Cream Man: Florean Fortescue had a ghost plot? How is Bill able to take Harry's money out of Gringotts without his permission? Why did Dumbledore refuse Auror protection for Harry in Diagon Alley? And is Hagrid really the best alternative? We discuss Weasley's Wizard Wheezes being a beacon of light in an otherwise very dark time Does Molly's concern for Fred and George stem from the loss of her brothers Gideon and Fabian in the First Wizarding War? Inside Madam Malkin's: who was worse, Narcissa or Harry? We compare the this confrontation to the one inside Flourish & Blott's in Chamber of Secrets. Why is Draco trying to operate in secrecy from his mother? And what in the world was Hermione thinking at the end of the chapter? Lynx Line: Patrons tell us what's really on Malfoy's forearm (wrong answers only!) Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Halloween-themed episode of The Profit Cleaners Podcast, Brandon Schoen and Brandon Condrey explore how innovative AI tools are transforming small business marketing. The spotlight is on Sora, OpenAI's groundbreaking video generation platform that empowers entrepreneurs to create engaging, high-quality content without the need for complex production teams or expensive equipment.Through practical examples and real-world experiments—from lighthearted Halloween ads featuring dancing characters to creative campaigns developed in-house—the Brandons demonstrate how AI can help cleaning business owners boost visibility, engagement, and profitability. Beyond the fun, this episode highlights the growing importance of adaptability, creativity, and storytelling in today's digital-first marketing landscape.Whether you're new to AI or ready to level up your brand strategy, this episode will inspire you to approach marketing with curiosity, innovation, and confidence.

It's time for the very first of Amanda's Fave Chaps, and the premiere selection is Book 6's “Snape Victorious”. We're renewing our membership to the Snape Haters Club, theorizing about who exactly is conducting the Hogwarts Express, and having a moment for Emo Tonks. Join us!Support the showSupport FFH on Patreon: patreon.com/thefoxandthefoxhoundFollow us!IG: @thefoxandthefoxhoundTikTok: @thefoxandthefoxhound

Find out who Bathilda is (unless, like Harry, you've already figured it out), whether or not Godric's Hollow suffers from the Charity Burbage Effect, and why Snape may have a case for a lawsuit on this week's One Page at a Time. Alice and Martha's excitement for returning to the seventh book may or may not have been justified with this page! Please consider supporting us on Patreon! www.patreon.com/realweirdsisters New episodes are released every Monday and special topics shows are released periodically. Don't forget to subscribe to our show to make sure you never miss an episode!

Help MuggleCast grow! Join us as our patron at Patreon.com/mugglecast, and receive a slew of great benefits instantly, including more than 60 hours of bonus recordings, 30 hours of chapter readings, and much, much more! Listeners can browse our official merch at MuggleCastMerch.com and pick up overstock items from years past at MuggleMillennial.Etsy.com! This week, join us as we wind our way to Spinner's End and throw ourselves at the mercy of everyone's (least) favorite Potions Master. Grab a tall glass of elf-made bloodred wine and toast the Dark Lord because its unlikely you'll make it out of this chapter without making an Unbreakable Vow. Welcome back, Irvin! Check out his new book Malfoy: The Most Treacherous Family, which is available now! Potter TV Show News: Our first look at John Lithgow as Albus Dumbledore! Chapter-by-Chapter continues with Half-Blood Prince Chapter 2: Spinner's End We analyze Snape's decision to remain in his childhood home. Could it be because of Lily? And why is it such bad shape? The Sisterhood of Bellatrix and Narcissa: do the two actually care for each other? Would Bellatrix rather be right or wrong about Snape's loyalty?  Snape vs. Bellatrix: we're here for snarky, sassy Severus Snape! Snape's allegiance: do we recall how we felt when first reading this chapter? Could there be trouble in paradise with Voldemort and Bellatrix? Did Narcissa manipulate Snape during the final step of the Unbreakable Vow? MVP: Who's the better chess master - Snape or Dumbledore? Lynx Line: Snape's childhood home is clearly a little drab - if Snape's home were the subject of a home makeover show, what would it be called? Participate in our weekly trivia segment by answering this week's Quizzitch question at MuggleCast.com/Quizzitch! Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is sponsored by Better Help - go to http://betterhelp.com/super to get 10% off your first month. Go to http://factormeals.com/jvsb50off and use code jvsb50off to get 50% off your first box, plus Free Breakfast for 1 Year. Hello and welcome everyone to the Owlery!  The show where we answer real questions delivered by a real owl! Today's letter is sent to us from Through The Griffin Door listener: Moose, who wants to know how the story would have changed if Snape had not insisted that his love for Lily be kept a secret for all of those years Sign up for the Owlery :: https://www.patreon.com/throughthegriffindoor  #HarryPotter #SuperCarlinBrother #WhatIf Written by :: J & Ben Carlin Edited by :: Isybelle Christley