Podcasts about apcs

We're almost at the halfway point of Prime Minister Mitsotakis' second term. Despite a few political storms over the past years, New Democracy, the prime minister's party, is riding out a wave of dissatisfaction among voters, holding steady at about 30 percent. At the same time, a rudderless and divided opposition can't seem to translate this into votes. Nektaria Stamouli, the deputy editor in chief of Kathimerini's English Edition and Politico's Eastern Mediterranean correspondent, joins Thanos Davelis as we take a deeper dive into Greece's current political landscape, from the ruling party to the fragmented opposition. You can read the articles we discuss on our podcast here:Greeks feel they have no one to vote forTsipras slams government, calls for progressive unityAthens agrees to send APCs to LebanonGreek court strips three far-right MPs of seats over electoral fraud

In this conversation, Marshall and Nick discuss various aspects of car detailing, focusing on community support, product comparisons, and the challenges of cleaning interiors. They highlight the importance of using the right products, such as Revive and Impress, and the risks associated with using all-purpose cleaners (APCs) on modern vehicles. The discussion also covers the significance of proper cleaning techniques for trim restoration and introduces a new trim cleaner and coating product. In this conversation, Nick and Marshall delve into the intricacies of automotive detailing, focusing on the importance of trim cleaning and coatings, the challenges posed by bug stains, and the sensitivity of modern car surfaces. They discuss polishing techniques, the evolution of compounding, and the specific care required for carbon fiber. The conversation also highlights the expansion of their YouTube channel to provide a broader car lifestyle experience.Chapters00:00 Community Support and Resilience02:57 Cleaning Challenges: Sunscreen and Makeup05:59 Product Comparisons: Revive vs. Impress09:01 The Risks of APCs in Modern Detailing12:02 Understanding Interior Damage and Repair15:07 Trim Restoration: The Importance of Proper Cleaning18:04 New Product Launch: Trim Cleaner and Coating24:19 The Importance of Trim Cleaning27:05 Understanding Trim Coatings29:32 Challenges with Bug Stains32:00 Dealing with Sensitive Surfaces34:29 Polishing Techniques and Mindset39:04 The Evolution of Compounding44:05 Carbon Fiber Care and Considerations46:57 Expanding the YouTube Experience

Can You Segway?Book 3 in 18 parts, By FinalStand. Listen to the ► Podcast at Explicit Novels.So exactly who was going to be sympathetic to their plight, who we cared about?Beyond my fevered dream of making a difference there was a pinch of reality. See, the Cabindans and the people of Zaire were both ethnic Bakongo and the Bakongo of Zaire had also once had their own, independent (until 1914) kingdom which was now part of Angola. The Bakongo were major factions in the Democratic Republic of Congo (DRC) -(formerly for a short time known as the nation of Zaire, from here on out to be referred to as the DRC and in the running for the most fucked up place on the planet Earth, more on that later)- and Congo (the nation) yet a minority in Angola. Having an independent nation united along ethnic and linguistic lines made sense and could expect support from their confederates across international boundaries.The Liberation Air ForceThe Earth & Sky operated under one constant dilemma ~ when would Temujin make his return? Since they didn't know and it was their job to be prepared for the eventuality if it happened tomorrow, or a century down the line, they 'stockpiled', and 'stockpiled' and 'stockpiled'.That was why they maintained large horse herds and preserved the ancient arts of Asian bowyers, armoring and weapons-craft. That was why they created secret armories, and sulfur and saltpeter sites when musketry and cannons became the new ways of warfare. They secured sources of phosphates and petroleum when they became the new thing, and so on.All of this boiled over to me being shown yet again I worked with clever, creative and under-handed people. The Khanate came up with a plan for a 'Union' Air Force {Union? More on that later} within 24 hours, and it barely touched any of their existing resources. How did they accomplish this miracle? They had stockpiled and maintained earlier generation aircraft because they didn't know when Temujin would make his re-appearance.They'd also trained pilots and ground crews for those aircraft. As you might imagine, those people grew old just as their equipment did. In time, they went into the Earth & Sky's Inactive Reserves ~ the rank & file over the age of 45. You never were 'too old' to serve in some capacity though most combat-support related work ended at 67.When Temujin made his return and the E&S transformed into the Khanate, those people went to work bringing their lovingly cared for, aging equipment up to combat-alert readiness. If the frontline units were decimated, they would have to serve, despite the grim odds of their survival. It was the terrible acceptance the Chinese would simply possess so much more war-making material than they did.Well, the Khanate kicked the PRC's ass in a titanic ass-whooping no one (else) had seen coming, or would soon forget. Factory production and replacement of worn machines was in stride to have the Khanate's Air Force ready for the next round of warfare when the Cease-fire ended and the Reunification War resumed.Always a lower priority, the Khanate military leadership was considering deactivating dozens of these reserve unit when suddenly the (Mongolian) Ikh khaany khairt akh dáé (me) had this hare-brained scheme about helping rebels in Africa, West Africa, along the Gulf of Guinea coast/Atlantic Ocean, far, far away, and it couldn't look like the Khanate was directly involved.They barely knew where Angola was. They had to look up Cabinda to figure out precisely where that was. They brought in some of their 'reservist' air staff to this briefing and one of them, a woman (roughly a third of the E&S 'fighting'/non-frontline forces were female), knew what was going on. Why?She had studied the combat records and performance of the types of aircraft she'd have to utilize... back in the 1980's and 90's and Angola had been a war zone rife with Soviet (aka Khanate) material back then. Since she was both on the ball, bright and knew the score, the War Council put her in overall command. She knew what was expected of her and off she went, new staff in hand. She was 64 years old, yet as ready and willing to serve as any 20 year old believer in the Cause.Subtlety, scarcity and audacity were the watchwords of the day. The Khanate couldn't afford any of their front-line aircraft for this 'expedition'. They really couldn't afford any of their second-rate stuff either. Fortunately, they had some updated third-rate war-fighting gear still capable of putting up an impressive show in combat ~ providing they weren't going up against a top tier opponents.For the 'volunteers' of the Union Air Force, this could very likely to be a one-way trip. They all needed crash courses (not a word any air force loves, I know) in Portuguese though hastily provided iPhones with 'apps' to act as translators were deemed to be an adequate stop-gap measure. Besides, they were advised to avoid getting captured at all cost. The E&S couldn't afford the exposure. Given the opportunity ~ this assignment really was going above and beyond ~ not one of these forty-six to sixty-seven year olds backed out.No, they rolled out fifty of their antiquated aircraft, designs dating back to the 1950's through the mid-70's, and prepared them for the over 10,000 km journey to where they were 'needed most'. 118 pilots would go (72 active plus 46 replacements) along with 400 ground crew and an equally aged air defense battalion (so their air bases didn't get blown up). Security would be provided by 'outsiders' ~ allies already on the ground and whatever rebels could be scrounged up. After the initial insertion, the Indian Air Force would fly in supplies at night into the Cabinda City and Soyo Airports.The composition,14 Mikoyan-Gurevich MiG-21 jet fighters ~ though she entered service in 1959, these planes' electronics were late 20th century and she was a renowned dogfighter. 12 were the Mig-21-97 modernized variant and the other two were Mig-21 UM two-seater trainer variants which could double as reconnaissance fighters if needed.14 Sukhoi Su-22 jet fighter-bombers ~ the original design, called the Su-17, came out in 1970, the first 12 were variants with the 22M4 upgrade were an early-80's package. The other 2 were Su-22U two-seat trainers which, like their Mig-21 comrades, doubled as reconnaissance fighters. The Su-22M4's would be doing the majority of the ground attack missions for the Cabindans, though they could defend themselves in aerial combat if necessary.6 Sukhoi Su-24M2 supersonic attack aircraft ~ the first model rolled off the production lines in the Soviet Union back in 1974. By far the heaviest planes in the Cabindan Air Force, the Su-24M2's would act as their 'bomber force' as well as anti-ship deterrence.8 Mil Mi-24 VM combat helicopters ~ introduced in 1972 was still a lethal combat machine today. Unlike the NATO helicopter force, the Mi-24's did double duty as both attack helicopter and assault transports at the same time.4 Mil Mi-8 utility helicopters, first produced in 1967. Three would act as troop/cargo transports (Mi-8 TP) while the fourth was configured as a mobile hospital (the MI-17 1VA).4 Antonov An-26 turboprop aircraft, two to be used as tactical transports to bring in supplies by day and two specializing in electronic intelligence aka listening to what the enemy was up to. Though it entered production in 1969, many still remained flying today.2 Antonov An-71M AEW&C twin-jet engine aircraft. These were an old, abandoned Soviet design the Earth & Sky had continued working on primarily because the current (1970's) Russian Airborne Early Warning and Control bird had been both huge and rather ineffective ~ it couldn't easily identify low-flying planes in the ground clutter so it was mainly only good at sea. Since the E&S planned to mostly fight over the land,They kept working on the An-71 which was basically 1977's popular An-72 with some pertinent design modifications (placing the engines below the wings instead of above them as on the -72 being a big one). To solve their radar problem, they stole some from the Swedish tech firm Ericsson, which hadn't been foreseen to be a problem before now.See, the Russians in the post-Soviet era created a decent AEW&C craft the E&S gladly stole and copied the shit out of for their front line units and it was working quite nicely ~ the Beriev A-50, and wow, were the boys in the Kremlin pissed off about that these days. Whoops, or was that woot?Now, the Khanate was shipping two An-71's down to Cabinda and somewhere along the line someone just might get a 'feel' for the style of radar and jamming the Cabindans were using aka the Swedish stuff in those An-71's. The Erieye radar system could pick out individual planes at 280 miles. The over-all system could track 60 targets and plot out 10 intercepts simultaneously. NATO, they were not, but in sub-Saharan Africa, there were none better.Anyway, so why was any of this important?Why the old folks with their ancient machines? As revealed, since the Earth & Sky had no idea when Temüjin would return, they were constantly squirreling away equipment. World War 2 gave them unequaled access to Soviet military technology and training.Afterwards, under Josef Stalin's direction, thousands of Russian and German engineers and scientists were exiled to Kazakhstan, Turkmenistan, Tajikistan, and Kyrgyzstan who were then snatched up (reportedly died in the gulags/trying to escape) and the E&S began building mirror factories modeled on the 'then current' Soviet production lines.So, by the early 1950's, the E&S was building, flying and maintaining Soviet-style Antonov, Beriev, Ilyushin, Myasishchev, Mikoyan-Gurevich, Sukhoi, Tupolev and Yakovlev airplanes. First in small numbers because their pool of pilots and specialists was so small.The E&S remedied this by creating both their own 'private' flight academies and technical schools. They protected their activities with the judicious use of bribes (they were remarkably successful with their economic endeavors on both side of the Iron Curtain) and murders (including the use of the Ghost Tigers).By 1960, the proto-Khanate had an air force. Through the next two decades they refined and altered their doctrine ~ moving away from the Soviet doctrine to a more pure combined-arms approach (the Soviets divided their air power into four separate arms ~ ADD (Long Range Aviation), FA (Front Aviation), MTA (Military Transport Aviation) and the V-PVO (Soviet Air Defenses ~ which controlled air interceptors).).It wasn't until the collapse of the Soviet Union and the independence of the various former SSR's that the E&S program really began to hit its stride. Still, while Russia faltered, China's PLAAF (Peoples' Liberation Army Air Force) began to take off. Since the Chinese could produce so much more, the E&S felt it had to keep those older planes and crews up to combat readiness. The younger field crews and pilots flew the newer models as they rolled off the secret production lines.Then the Unification War appeared suddenly, the E&S-turned Khanate Air Force skunked their PLAAF rivals due to two factors, a surprise attack on a strategic level and the fatal poisoning of their pilots and ground crews before they even got into the fight. For those Chinese craft not destroyed on the ground, the effects of Anthrax eroded their fighting edge. Comparable technology gave the Khanate their critical victory and Air Supremacy over the most important battlefields.What did this meant for those out-of-date air crews and pilots who had been training to a razor's edge for a month now? Their assignment had been to face down the Russians if they invaded. They would take their planes up into the fight even though this most likely would mean their deaths, but they had to try.When Operation Fun House put Russia in a position where she wasn't likely to jump on the Khanate, this mission's importance faded. The Russian Air Force was far more stretched than the Khanate's between her agitations in the Baltic and her commitments in the Manchurian, Ukrainian, Chechen and Georgian theaters.With more new planes rolling off the production lines, these reservist units began dropping down the fuel priority list, which meant lowering their flight times thus readiness. Only my hare-brained scheme had short-circuited their timely retirement. Had I realized I was getting people's grandparents killed, I would have probably made the same call anyway. We needed them.The KanateThe Khanate's #1 air superiority dogfighter was the Mig-35F. The #2 was the Mig-29. No one was openly discussing the Khanate's super-stealthy "Su-50", if that was what it was, because its existence 'might' suggest the Khanate also stole technology from the Indian defense industry, along with their laundry list of thefts from South Korea, Japan, Taiwan, the PRC, Russia and half of NATO.Her top multi-role fighters were the Su-47, Su-35S and Su-30SM. The Su-30 'Flanker-C/MK2/MKI were their 2nd team with plenty of 3rd team Su-27M's still flying combat missions as well.Strike fighters? There weren't enough Su-34's to go around yet, so the Su-25MS remained the Khanate's dedicated Close Air Assault model.Medium transport aircraft? The An-32RE and An-38. They had small, large and gargantuan transports as well.Bombers? The rather ancient jet-powered Tu-160M2's and Tu-22M2's as well as the even older yet still worthwhile turboprops ~ from 1956's ~ the Tu-95M S16.Helicopters? While they still flew updated variants of the Mil Mi-8/17 as military transports, the more optimized Kamov Ka-52 and Mil Mi-28 had replaced them in the assault role.Bizarrely, the Khanate had overrun several Chinese production lines of the aircraft frames and components ~ enough to complete fairly modern PLAAF (Peoples Liberation Army Air Force) FC-1 and J-10 (both are small multi-role fighter remarkably similar to the US F-16 with the FC-1 being the more advanced model, using shared Chinese-Pakistani technology and was designed for export,).They did have nearly two dozen to send, but they didn't have the pilots and ground crews trained to work with them, plus the FC-1 cost roughly $32 million which wasn't fundage any legitimate Cabindan rebels could get their hands on, much less $768 million (and that would just be for the planes, not the weeks' worth of fuel, parts and munitions necessary for what was forthcoming).Meanwhile, except for the An-26, which you could get for under $700,000 and the An-71, which were only rendered valuable via 'black market tech', none of the turboprop and jet aircraft the Khanate was sending were what any sane military would normally want. The helicopters were expensive ~ the 'new' models Mi-24's cost $32 million while the Mi-17's set you back $17 million. The one's heading to Cabinda didn't look 'new'.The Opposition:In contrast, the Angolan Air Force appeared far larger and more modern. Appearances can be deceptive, and they were. Sure, the models of Russian and Soviet-made aircraft they had in their inventory had the higher numbers ~ the Su-25, -27 and -30 ~ plus they had Mig-21bis's, Mig-23's and Su-22's, but things like training and up-keep didn't appear to be priorities for the Angolans.When you took into account the rampant corruption infecting all levels of Angolan government, the conscript nature of their military, the weakness of their technical educational system, the complexity of any modern combat aircraft and the reality that poor sods forced into being Air Force ground crewmen hardly made the most inspired technicians, or most diligent care-takers of their 'valuable' stockpiles (which their officers all too often sold on the black market anyway), things didn't just look bleak for the Angolan Air Force, they were a tsunami of cumulative factors heading them for an epic disaster.It wasn't only their enemies who derided their Air Force's lack of readiness. Their allies constantly scolded them about it too. Instead of trying to fix their current inventory, the Angolans kept shopping around for new stuff. Since 'new'-new aircraft was beyond what they wanted to spend (aka put too much of a dent in the money they were siphoning off to their private off-shore accounts), they bought 'used' gear from former Soviet states ~ Belarus, Russia and Ukraine ~ who sold them stuff they had left abandoned in revetments (open to the elements to slowly rot) on the cheap.To add to the insanity, the Angolans failed to keep up their maintenance agreements so their newly fixed high-tech machines often either couldn't fly, or flew without critical systems, like radar, avionics and even radios. Maybe that wasn't for the worst because after spending millions on these occasionally-mobile paperweights, the Angolans bought the least technologically advanced missile, gun and rocket systems they could get to put on these flying misfortunes.On the spread sheets, Angola had 18 Su-30K's, 18 Su-27, 12 Su-25's, 14 Su-22's, 22 Mig-23's, 23 Mig-21bis's and 6 Embraer EMB 314 Super Tucano (a turboprop aircraft tailor-made for counter-insurgency operations), 105 helicopters with some combative ability and 21 planes with some airlift capacity. That equated to 81 either air superiority, or multi-role jet fighters versus the 12 Union Air Force (actually the Bakongo Uni o de Cabinda e Zaire, For as Armadas de Liberta  o, For a Area ~ Liberation Armed Forces, Air Force (BUCZ-FAL-FA) Mig-21-97's.It would seem lopsided except for the thousands of hours of flight experience the 'Unionists' enjoyed over their Angolan rivals. You also needed to take into account the long training and fanatic dedication of their ground crews to their pilots and their craft. Then you needed to take into account every Unionist aircraft, while an older airframe design, had updated (usually to the year 2000) technology lovingly cared for, as if the survival of their People demanded it.A second and even more critical factor was the element of surprise. At least the PRC and the PLAAF had contingencies for attacks from their neighbors in the forefront of their strategic planning. The Angolans? The only country with ANY air force in the vicinity was the Republic of South Africa (RSA) and they had ceased being a threat with the end of Apartheid and the rise of majority Black rule in that country nearly two decades earlier.In the pre-dawn hours of 'Union Independence Day', the FAL-FA was going to smash every Angolan Air base and air defense facility within 375 miles of Cabinda (the city). Every three hours after that, they would be hitting another target within their designated 'Exclusion Zone'. Yes, this 'Exclusion Zone' included a 'tiny' bit of DRC (Democratic Republic of Congo) territory. The DRC didn't have an air force to challenge them though, so,Inside this 'Exclusion Zone', anything moving by sea, river, road, rail, or air without Unionist governmental approval was subject to attack, which would require neutral parties to acknowledge some semblance of a free and independent B U C Z. Worse for Angola, this 'Zone' included Angola's capital and its largest port, Luanda, plus four more of their ten largest urban centers. This could be an economic, military and humanitarian catastrophe if mishandled.The Angolan Army did not have significant anti-aircraft assets. Why would they? Remember, no one around them had much of an air force to worry about. The FAL-FA in turn could hit military convoys with TV-guided munitions 'beyond line of sight', rendering what they did have useless. It got worse for the Army after dark. The FAL-FA could and would fly at night whereas the average Angolan formation had Zip-Zero-Nadda night fighting capacity.Then geography added its own mountain of woes. As far as Cabinda was concerned, there was no direct land line to their border from Angola. Their coastal road only went as far as the port of Soyo where the Congo River hit the South Atlantic Ocean. Across that massive gap was the DRC where the road was not picked back up. Far up the coast was the DRC town of Muanda (with an airport) and though they did have a road which went north, it did not continue to the Cabindan border.Nope. To get at Cabinda from the south meant a long, torturous travel through northeastern Angola, into the heart of the DRC then entailed hooking west to some point 'close' to the Cabindan frontier before finally hoofing it overland through partially cleared farmland and jungle. Mind you, the DRC didn't have a native air force capable of protecting the Angolans in their territory so,In fact the only 'road' to Cabinda came from the Republic of Congo (Congo) to the north and even that was a twisted route along some really bad, swampy terrain. This had been the pathway of conquest the Angolans took 39 years earlier. The difference being the tiny bands of pro-independence Cabindan guerillas back then couldn't hold a candle to the Amazons fighting to free Cabinda this time around in numbers, zeal, training and up-to-date equipment.Next option ~ to come by sea. They would face a few, stiff problems, such as the FAL-FA having ship-killer missiles, the Angolan Navy not being able to defend them and the Unionists having no compunction to not strike Pointe-Noire in the 'not so neutral' Republic of the Congo if they somehow began unloading Angolan troops. It seemed the Republic of the Congo didn't have much of an Air Force either.Before you think the FAL-FA was biting off more than they could chew, Cabinda, the province, was shaped somewhat like the US State of Delaware, was half the size of Connecticut (Cabinda was 2,810 sq. mi. to Conn.'s 5,543 sq. mi.) and only the western 20% was relatively open countryside where the Angolan Army's only advantage ~ they possessed armed fighting vehicles while the 'Unionists' did not (at this stage of planning) ~ could hopefully come into play.Centered at their capital, Cabinda (City), jets could reach any point along their border within eight minutes. Helicopters could make it in fifteen. To be safe, some of the FAL-FA would base at the town of Belize which was in the northern upcountry and much tougher to get at with the added advantage the Angolans wouldn't be expecting the FAL-FA to be using the abandoned airfield there, at least initially.Where they afraid attacking Angolan troops in the DRC would invite war with the DRC? Sure, but letting the Angolans reach the border unscathed was worse. Besides, the DRC was in such a mess it needed 23,000 UN Peacekeepers within her borders just to keep the country from falling apart. Barring outside, read European, intervention, did "Democratically-elected since 2001" President (for Life) Joseph Kabila want the FAL-FA to start dropping bombs on his capital, Kinshasa, which was well within reach of all their aircraft?Congo (the country), to the north, wasn't being propped up by the UN, or anything else except ill intentions. In reality, it hardly had much of a military at all. Its officer corps was chosen for political reliability, not merit, or capability. Their technology was old Cold War stuff with little effort to update anything and, if you suspected corruption might be a problem across all spectrums of life, you would 'probably' be right about that too.If you suspected the current President had been in charge for a while, you would be correct again (1979-1992 then 2001- and the 'whoops' was when he accidently let his country experiment with democracy which led to two civil wars). If you suspected he was a life-long Communist (along with the Presidents of the DRC and Angola), you'd be right about that as well. Somehow their shared Marxist-Leninist-Communist ideology hadn't quite translated over to alleviating the grinding poverty in any of those countries despite their vast mineral wealth,At this point in the region's history, little Cabinda had everything to gain by striving for independence and the vast majority of 'warriors' who could possibly be sent against her had terribly little to gain fighting and dying trying to stop them from achieving her goal. After all, their lives weren't going to get any better and with the Amazons ability ~ nay willingness ~ to commit battlefield atrocities, those leaders were going to find it hard going to keep sending their men off to die.And then, it got even worse.See, what I had pointed out was there were two oil refineries in Angola, and neither was in Cabinda. Cabinda would need a refinery to start making good on their oil wealth ~ aka economically bribe off the Western economies already shaken over the Khanate's first round of aggressions.But wait! There was an oil refinery just across the Congo River from Cabinda ~ which meant it was attached to mainland Angola. That had to be a passel of impossible news, right?Nope. As I said earlier, it seemed the people of northern Angola were the same racial group as the Cabindans AND majority Catholic while the ruling clique wasn't part of their ethnic confederacy plus the farther south and east into Angola you went, the less Catholic it became.But it got better. This province was historically its own little independent kingdom (called the Kingdom of Kongo) to boot! It had been abolished by Portugal back in 1914.The 'good' news didn't end there. Now, it wasn't as if the leadership of Angola was spreading the wealth around to the People much anyway, but these northerners had been particularly left out of this Marxist version of 'Trickle Down' economics.How bad was this? This northwestern province ~ called Zaire ~ didn't have any railroads, or paved roads, linking it to the rest of the freaking country. The 'coastal road' entered the province, but about a third of the way up ran into this river, which they'd failed to bridge (you had to use a single track bridge farther to the northeast, if you can believe it). It wasn't even a big river. It was still an obstacle though.How did the Angolan government and military planned to get around? Why by air and sea, of course. Well, actually by air. Angola didn't have much of a merchant marine, or Navy, to make sealift a serious consideration. Within hours of the 'Union Declaration of Independence' anything flying anywhere north of the Luanda, the capital of Angola, would essentially be asking to be blown out of the sky.Along the border between Zaire province and the rest of Angola were precisely two chokepoints. By 'chokepoints', I meant places where a squad (10 trained, modernly-equipped troopers) could either see everything for miles & miles over pretty much empty space along a river valley and the only bridge separating Zaire province from the south, or overlook a ravine which the only road had to pass through because of otherwise bad-ass, broken terrain.Two.Zaire Province had roughly the same population as Cabinda ~ 600,000. Unlike Cabinda, which consisted of Cabinda City plus a few tiny towns and rugged jungles, Zaire had two cities ~ Soyo, with her seventy thousand souls plus the refinery at the mouth of the Congo River, and M'banza-Kongo, the historical capital of the Kingdom of Kongo, spiritual center of the Bakongo People (who included the Cabindans) and set up in the highlands strategically very reminiscent of Điện Biàn Phủ.Of Zaire's provincial towns, the only other strategic one was N'Zeto with her crappy Atlantic port facility and 2,230 meter grass airport. The town was the northern terminus of the National Road 100 ~ the Coastal Road. It terminated because of the Mebridege River. There wasn't a bridge at N'Zeto though there was a small one several miles upstream. N'Zeto was also where the road from provinces east of Zaire ended up, so you had to have N'Zeto ~ and that tiny bridge ~ to move troops overland anywhere else in Zaire Province.So you would think it would be easy for the Angolan Army to defend then, except of how the Amazons planned to operate. They would infiltrate the area first then 'rise up in rebellion'. Their problem was the scope of the operation had magnified in risk of exposure, duration and forces necessary for success.The serious issue before Saint Marie and the Host in Africa were the first two. They could actually move Amazons from Brazil and North America to bolster their numbers for the upcoming offensive. Even in the short-short term, equipment wouldn't be a serious problem. What the Amazons dreaded was being left in a protracted slugfest with the Angolan Army which the Condottieri could jump in on. The Amazons exceedingly preferred to strike first then vanish.There was reason to believe a tiny number could have stayed behind in Cabinda to help the locals prepare their military until they could defend themselves. They would need more than a hundred Amazons if Cabinda wanted to incorporate Zaire. The answer was to call back their newfound buddy, the Great Khan. While he didn't have much else he could spare (the Khanate was ramping up for their invasion of the Middle East after all, the Kurds needed the help), he had other allies he could call on.India couldn't help initially since they were supposed to supply the 'Peace-keepers' once a cease-fire had been arranged. That left Temujin with his solid ally, Vietnam, and his far shakier allies, the Republic of China and Japan.First off ~ Japan could not help, which meant they couldn't supply troops who might very well end up dead, or far worse, captured.. What they did have was a surplus of older equipment the ROC troops were familiar with, so while the ROC was gearing up for their own invasion of mainland China in February, they were willing to help the Chinese kill Angolans, off the books, of course.The ROC was sending fifteen hundred troops the Khanate's way to help in this West African adventure with the understanding they'd be coming home by year's end. With Vietnam adding over eight hundred of her own Special Forces, the Amazons had the tiny 'allied' army they could leave shielding Cabinda/Zaire once the first round of blood-letting was over.To be 'fair', the Republic of China and Vietnam asked for 'volunteers'. It wasn't like either country was going to declare war on Angola directly. Nearly a thousand members of Vietnam's elite 126th Regiment of the 5th Brigade (Đặc cáng bộ) took early retirement then misplaced their equipment as they went to update their visas and inoculations before heading out for the DRC (some would be slipping over the DRC/Cabindan border).On Taiwan, it was the men and women of the 602nd Air Cavalry Brigade, 871st Special Operations Group and 101st Amphibious Reconnaissance Battalion who felt the sudden desire to 'seek enlightenment elsewhere, preferably on another continent'.They too were off to the Democratic Republic of Congo, man that country was a mess and their border security wasn't worth writing home about, that's for damn sure, via multiple Southeast Asian nations. Besides, they were being issued fraudulently visas which showed them to be from the People's Republic of China, not the ROC/Taiwan. If they were captured, they were to pretend to "be working for a Communist Revolution inside Angola and thus to be setting all of Africa on fire!" aka be Mainland Chinese.There, in the DRC, these Chinese stumbled across, some Japanese. These folks hadn't retired. No. They were on an extended assignment for the UN's mission in, the DRC. OH! And look! They'd brought tons of surplus, outdated Japanese Self Defense Forces' equipment with them, and there just so happened to be some Taiwanese who had experience in using such equipment (both used US-style gear).And here was Colonel Yoshihiro Isami of the Chūō Sokuō Shūdan (Japan's Central Readiness Force) wondering why he and his hastily assembled team had just unloaded,18 Fuji/Bell AH-1S Cobra Attack helicopters,6 Kawasaki OH-6D Loach Scout helicopters,12 Fuji-Bell 204-B-2 Hiyodori Utility helicopters,6 Kawasaki/Boeing CH-47JA Chinook Transport helicopters and4 Mitsubishi M U-2L-1 Photo Reconnaissance Aircraft.Yep! 46 more aircraft for the FAL-FA!Oh, and if this wasn't 'bad enough', the Chinese hadn't come alone. They'd brought some old aircraft from their homes to aid in the upcoming struggle. Once more, these things were relics of the Cold War yet both capable fighting machines and, given the sorry state of the opposition, definitely quite deadly. A dozen F-5E Tiger 2000 configured primarily for air superiority plus two RF-5E Tigergazer for reconnaissance, pilots plus ground crews, of course.Thus, on the eve of battle, the FAL-FA had become a true threat. Sure, all of its planes (and half of its pilots) were pretty old, but they were combat-tested and in numbers and experience no other Sub-Saharan African nation could match.The Liberation Ground Forces:But wait, there was still the niggling little problem of what all those fellas were going to fight with once they were on the ground. Assault/Battle rifles, carbines, rifles, pistols, PDW, SMGs as bullets, grenades and RPG's were all terrifyingly easy to obtain. The coast of West Africa was hardly the Port of London as far as customs security went. They were going to need some bigger toys and their host nations were going to need all their native hardware for their upcoming battles at home.And it wasn't like you could advertise for used IFV (Infantry Fighting Vehicles), APCs (armored personnel carriers) and tanks on e-Bay, Amazon.com, or Twitter. If something modern US, or NATO, was captured rolling around the beautiful Angolan countryside, shooting up hostile Angolans, all kinds of head would roll in all kinds of countries, unless the country,A) had an Executive Branch and Judiciary who wouldn't ask (or be answering) too many uncomfortable questions,B) wasn't all that vulnerable to international pressure,C) really needed the money and,D) didn't give a fuck their toys would soon be seen on BBC/CNN/Al Jazeera blowing the ever-living crap out of a ton of Africans aka doing what they were advertised to do and doing it very well in the hands of capable professionals.And politics was kind enough to hand the freedom-loving people of Cabinda & Zaire a winner, and it wasn't even from strangers, or at least people all that strange to their part of the Globe. If you would have no idea who to look for, you wouldn't be alone.That was the magic of the choice. See, the last three decades had seen the entire Globe take a colossal dump on them as a Nation and a People. They were highly unpopular for all sorts of things, such as Crimes Against Humanity and 'no', we were not talking about the Khanate.We would be talking about Република Србија / Republika Srbija aka Serbia aka the former Yugoslavia who had watched all their satellite minions (Slovenia, Croatia, Bosnia & Herzegovina, Montenegro, Kosovo and Macedonia) slip away. Despite being reduced to a tiny fraction of their former selves thus fighting two incredibly brutal and bloody World Wars for nothing, Serbia insisted on maintaining a robust armaments industry.Mind you, they didn't make the very best stuff on the planet. That didn't stop them from trying though. Of equal importance was their geographic location and the above mentioned desire for some hard currency without asking too many questions. The geography was simple, you could move even heavy gear unnoticed from central Serbia to the Montenegrin port of Bar by rail and load them up on freighters and off to the Congo you went.The Serbians produced an APC called the BVP M-80A's which weren't blowing anyone's minds away when they started rolling off the production lines back in 1982, plus some over-eager types on the Serbian Army's payroll sweetened the deal by offering 'the rebels' some BVP M-80 KC's and a KB as well.Then they slathered on the sugary-sweet Maple syrup by upgrading a few of the M-80A's to BVP M-98A's. Why would they be so generous? The KC's and KB were the Command & Control variants, so that made sense (C = company & B = battalion commander). The -98A had never been tested in the field before and they were kind of curious how the new turrets (which was the major difference) would behave. 'Our' procurement agents didn't quibble. We needed the gear.Besides, these Slavic entrepreneurs gave them an inside track on some 'disarmed/mothballed' Czech (introduced in 1963) armored mobile ambulances and Polish BWP-1 (first rolled out in 1966) APC's which were either in, or could be quickly configured into, the support variants those ground-fighters would need. The 'disarmed' part was 'fixable', thanks to both the Serbians and Finland. The 'missing' basic weaponry was something the Serbians could replace with virtually identical equipment.It just kept getting better. Unknown to me at the time, the Finnish firm, Patria Hágglunds, had sold twenty-two of their 'most excellent' AMOS turrets ~ they are a twin 120 mm mortar system ~ then the deal fell through. Whoops! Should have guarded that warehouse better. Those bitches were on a cargo plane bound for Albania inside of six hours.The ammunition for them was rather unique. Thankfully, it was uniquely sold by the Swiss, who had no trouble selling it to Serbia, thank you very much! Twenty-two BWP-1's became mobile artillery for the Unionist freedom fighters, though I understood the ship ride with the Serbian and Chinese technicians was loads of fun as they struggled to figured out how to attach those state-of-the-art death-dealing turrets to those ancient contraptions.To compensate, the Serbians added (aka as long as our money was good) two Nora B-52 155 mm 52-calibre mobile artillery pieces and one battery of Orkan CER MLRS (Multiple Launch Rocket System) for long-range artillery, two batteries of their Oganj 2000 ER MRLS for medium range carnage and six batteries of their M-94 MRLS for 'close support' as well. More field-testing new gear for the "freedom fighters" We also managed to 'purchase' ten M-84AS Main Battle tanks plus an M-84A1 armor recovery vehicle. It should have been twelve tanks, but two had 'loading issues'.Not to be deterred, our busy little procurement-beavers discovered four tanks no one was using, in neighboring Croatia. Why wasn't anyone immediately keen on their placement? They were two sets of prototypes, Croatia's improvements on the M-84; the M-95 Degman which was a 'failed redesign' and the M-84D, which was a vast up-grade for the M-84 line which had been sidelined by the 2008 Global economic collapse, after which the project stagnated.It seemed they were all in working order because late one night 'my people' exited a Croatian Army base with them, never to be seen again, until two weeks later when an intrepid news crew caught the distinctive form of the M-95 sending some sweet 125 mm loving the Angolan Army's way. Whoops yet again! At least they hit what they were aiming at and destroyed what they hit, right?By then, millions of other people would be going 'what the fuck?' right along with them as Cabinda's camouflage- and mask-wearing rebel army was laying the smack-down on the Angolans. That was okay; over a million 'free Cabindan Unionists' were in the same boat. Over a thousand Asians with their mostly-female militant translators were right there to prop up their 'Unionist Allies', but then they were the ones with the tanks, armored vehicles, planes and guns, so they were less worried than most.To pilot these tanks, APC, IFV and man this artillery, they had to go back to the Khanate. Sure enough, they had some old tankers used to crewing the T-72 from which the M-84's and -95 Degman were derived. They'd also need drivers for those BVP M-80A's and Polish BWP-1's and OT-64 SKOT's... who were, again, derived from old Soviet tech (just much better). The Serbian artillery was similar enough to Soviet stuff, but with enough new tech to make it 'more fun' for the reservists to 'figure out' how to use.More volunteers for the Liberation Armed Forces! More Apple sales, great apps and voice modulation software so that the vehicle commanders would be heard communicating in Portuguese if someone was eavesdropping. As a final offering the Turkish Navy spontaneously developed some plans to test their long range capabilities by going to, the South Atlantic.On the final leg they would have six frigates and two submarines, enough to give any navy in the region, which wasn't Brazil, something to think about. This was a show of force, not an actual threat though. If anyone called their bluff, the Khanate-Turkish forces would have to pull back. These were not assets my Brother, the Great Khan, could afford to gamble and lose.If someone didn't call that bluff, he was also sending two smaller, older corvettes and three even smaller, but newer, fast attack boats, a "gift" to the Unionists ASAP. The frigates would then race home, they had 'other' issues to deal with while the submarines would hang around for a bit. The naval gift was necessitated by the reality the Unionists would have to press their claim to their off-shore riches and that required a naval force Angola couldn't hope to counter.As things were developing, it was reckoned since a build-up of such momentous land and air power couldn't be disguised, it had to happen in a matter of days ~ four was decided to be the minimum amount of time. More than that and the government of the Democratic Republic might start asking far too many questions our hefty bribes and dubious paperwork couldn't cover. Less than that would leave the task forces launching operations with too little a chance of success.Our biggest advantage was audacity. The buildup would happen 100 km up the Congo River from Soyo, the primary target of the Southern Invasion, in the DRC's second largest port city, Boma. Though across the river was Angolan territory, there was nothing there. The city of roughly 160,000 would provide adequate cover for the initial stage of the invasion.There they grouped their vehicles & Khanate drivers with Amazon and Vietnamese combat teams. The Japanese were doing the same for their 'Chinese' counterparts for their helicopter-borne forces. Getting all their equipment in working order in the short time left was critical as was creating some level of unit dynamic. Things were chaotic. No one was happy. They were all going in anyway.What had gone wrong?While most children her age were texting their schoolmates, or tackling their homework, Aya Ruger ~ the alias of Nasusara Assiyaiá hamai ~ was getting briefings of her global, secret empire worth hundreds of billions and those of her equally nefarious compatriots. She received a very abbreviated version of what the Regents received, delivered by a member of Shawnee Arinniti's staff.When Aya hopped off her chair unexpectedly, everyone tensed. Her bodyguards' hands went to their sidearms and Lorraine (her sister by blood), also in the room on this occasion, stood and prepared to tackle her 'former' sibling to the ground if the situation escalated into an assassination attempt. No such attack was generated, so the security ratcheted down and the attendant returned her focus to her Queen. Aya paced four steps, turned and retraced her way then repeated the action three more times."How many people live in the combined areas?" she asked."The combined areas? Of Cabinda and Zaire?""Yes.""I," the woman referenced her material, "roughly 1.1 million.""What is the yearly value of the offshore oil and natural gas production?""Forty-nine billion, eighty hundred and sixty-seven million by our best estimates at this time,""How many live in Soyo City proper?""Roughly 70,000.""We take Soyo," she spoke in a small yet deliberate voice. "We take and hold Soyo as an independent city-state within the Cabindan-Zaire Union. From the maps it appears Soyo is a series of islands. It has a port and airport. It has an open border to an ocean with weaker neighbors all around.""What of the, Zairians?""Bakongo. As a people they are called the Bakongo," Aya looked up at the briefer. "We relocate those who need to work in Soyo into a new city, built at our expense, beyond the southernmost water barrier. The rest we pay to relocate elsewhere in Zaire, or Cabinda."By the looks of those around her, Aya realized she needed to further explain her decisions."This is more than some concrete home base for our People," she began patiently. "In the same way it gives our enemies a clearly delineated target to attack us, it is a statement to our allies we won't cut and run if things go truly bad.""In the same way it will provide us with diplomatic recognition beyond what tenuous handouts we are getting from Cáel Wakko Ishara's efforts through JIKIT. Also, it is a reminder we are not like the other Secret Societies in one fundamental way, we are not a business concern, or a religion. We are a People and people deserve some sort of homeland. We have gone for so long without.""But Soyo?" the aide protested. "We have no ties to it, and it backs up to, nothing.""Northern Turkey and southern Slovakia mean nothing to us now as well," Aya debated. "No place on Earth is any more precious than another. As for backing up to nothing, no. You are incorrect. It backs into a promise from our allies in the Earth & Sky that if we need support, they know where to park their planes and ships."Aya was surrounded with unhappy, disbelieving looks."The Great Khan is my mamētu meáeda," she reminded them, "and I have every reason to believe he completely grasps the concept's benefits and obligations."The looks confirmed 'but he's a man' to the tiny Queen."Aya, are you sure about this?" Lorraine was the first to break decorum."Absolutely. Do you know what he sent me when he was informed of my, ascension to the Queendom?""No," Lorraine admitted."We must go horse-riding sometime soon, Daughter of Cáel, Queen of the Amazons."More uncertain and unconvinced looks."He didn't congratulate me, or send any gifts. He could have and you would think he would have, but he didn't. He knew the hearts of me & my Atta and we weren't in the celebratory mood. No. The Great Khan sent one sentence which offered solace and quiet, atop a horse on a windswept bit of steppe."Nothing.Sigh. "I know this sounds Cáel-ish," Aya admitted, "but I strongly believe this is what we should do. We are giving the Cabindans and Bakongo in Zaire independence and the promise of a much better life than what they now face. We will be putting thousands of our sisters' lives on the line to accomplish this feat and well over two hundred million dollars.""What about governance of the city ~ Soyo?" the aide forged ahead."Amazon law," Aya didn't hesitate. "We will make allowances for the security forces of visiting dignitaries and specific allied personnel, but otherwise it will be one massive Amazon urban freehold.""I cannot imagine the Golden Mare, or the Regents, will be pleased," the attendant bowed her head."It is a matter of interconnectivity," Aya walked up and touched the woman's cheek with the back of her small hand. "We could liberate then abandon Cabinda with the hope a small band could help them keep their independence. Except we need the refinery at Soyo so the people of Cabinda can truly support that liberty.""So, we must keep Soyo and to keep Soyo, we must keep Zaire province. There is no other lesser border which makes strategic sense ~ a river, highlands, a massive river, an ocean ~ those are sustainable frontiers. You can't simply keep Soyo and not expect the enemy to strike and destroy that refinery, thus we must take Zaire province.""But the Bakongo of Zaire cannot defend themselves and will not be able to do so for at least a year, if not longer. That means we must do so, and for doing so, they will give us Soyo and we will be honest stewards of their oil wealth. We cannot expect any other power to defend this new Union and if we don't have a land stake we will be portrayed as mercenaries and expelled by hostile international forces.""So, for this project to have any chance of success, we must stay, fight and have an acknowledged presence, and if you can think of an alternative, please let me know," she exhaled."What if the Cabindans and Bakongo resist?""It is 'us', or the Angolans and they know how horrible the Angolans can be. Didn't you say the average person their lives on just $2 a day?""Yes.""We can do better than that," Aya insisted."How?" the aide persisted. "I mean, 'how in a way which will be quickly evident and meaningful?'""Oh," Aya's tiny brow furrowed. Her nose twitched as she rummaged through the vast storehouse of her brain."Get me in touch with William A. Miller, Director of the U.S. Diplomatic Security Service. He should be able to help me navigate the pathways toward getting aid and advisors into those two provinces ASAP.""I'll let Katrina know," the attendant made the notation on her pad."No. Contact him directly," Aya intervened. "We established a, rapport when we met. I think he might responded positively to a chance to mentor me in foreign relations.""Really?" Lorraine's brows arched."Yes," Aya chirped."Are you sure, Nasusara?" the attendant stared. She used 'Nasusara' whenever she thought Aya had a 'horrible' idea instead of a merely a 'bad' one."Yes. He owes me. Last time we met I didn't shoot him.""Didn't?" the woman twitched."Yes. I drew down on him with my captured Chinese QSW-06. I didn't want to kill him, but I felt I was about to have to kill Deputy National Security Advisor Blinken and he was the only other person in the room both armed and capable of stopping me.""Why is he still alive?""Cáel Ishara saw through my distraction and then took my gun from me, asked for it actually," she shyly confessed."Would you have shot him?" the aide inquired."What do you think?" Aya smiled.And Then:So, given t

In this episode, we detail the role of immunoglobulins in gut-immune function, examining their involvement in mucosal defense, microbial regulation, and immune homeostasis within the intestines. We discuss the mechanisms of antibody production, highlighting how secretory IgA (sIgA) contributes to intestinal barrier integrity and pathogen neutralization. We also detail low secretory immunoglobulin A levels and Candida overgrowth. Lastly, we go through tools to support the gut-immune axis including oral immunoglobulin supplementation.1. Introduction   - Overview of immunoglobulins, roles in gut-immune health     - The gut as a constant interface with antigens, microbes, and potential pathogens     - Adequate but balanced immunoglobulin levels; preventing opportunistic pathogen overgrowth   2. Immunoglobulins     - Immunoglobulins (Ig) as glycoproteins, fundamental role in immune defense     - Five major immunoglobulin isotypes and their distinct roles     - How immunoglobulins recognize and neutralize pathogens / toxins / foreign antigens   3. Antibody Production in the Intestines    - Naïve B cells originate in the bone marrow, migrate to secondary lymphoid tissues     - Antigen-presenting cells (APCs) facilitate antigen processing and B cell activation     - Plasma cells and mucosal immunity   4. The Intestinal Barrier and Immune Components   - Layers of the gut barrier and their functions     - The role of gut-associated lymphoid tissue (GALT) in immune surveillance     - Immune cells within the lamina propria and their contributions to gut homeostasis   5. Secretory IgA (sIgA) and Its Role in Gut Immunity    - sIgA production and transport across the intestinal epithelium    - Role of sIgA in immune exclusion and pathogen neutralization  6. Factors That Can Influence sIgA Levels    - Chronic stress, infections, and gut inflammation as contributors to low sIgA     - Consequences of low sIgA, including increased susceptibility to pathogens     - Nutrients essential for supporting optimal sIgA levels   7. Other Key Immunoglobulins in Gut Immunity   - Immunoglobulin G's role in immune responses / pathogen neutralization    - Immunoglobulin M's location and function as an early immune responder in mucosal defense   8. Supplemental Immunoglobulins   - Oral immunoglobulin supplementation and its benefits    - Bovine colostrum as a source of immunoglobulins for intestinal and immune support   9. Conclusion     - Recap of immunoglobulins' role in gut-immune function    - The importance of balanced IgA, IgG, and IgM levels     - Strategies to support gut immunityThank you to our episode sponsor:1. Shop ⁠⁠CYLN's⁠⁠ full skincare line ⁠⁠here⁠⁠.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Good and bad unintended consequences.By FinalStand. Listen to the Podcast at Explicit Novels.The highest cost of losing a war is the rage of your children."Maybe the Canadian is not so much an 'ex' girlfriend?" Orsi leered. It was the old 'if he is so good that she still wants him back after a colossal screw up, I wanted a taste' expression."Do you think she will help you?" Katalin inquired."She'll help," Pamela huffed playfully. "My grandson has plenty of ex-girlfriends. Most of them want him back, despite his colorful lifestyle. It is one of his more amusing qualities.""Let's get something to eat," I tried to turn the conversation away from my past sexcapades."You are engaged?" Jolan didn't miss a beat."It is complicated," I sighed. "Let's just say I really like her, but she's seven years older, divorced with one young daughter and has a father who hates that I live and breathe.""Do you have any male friends?" Monika joined the Cáel Quiz Bowl."Yes," I replied with confidence. "My roommate Timothy and I are great friends.""He's gay," Pamela pierced their disbelief. "He and Cáel are true brothers-in-arms, I'll give Cáel that much.""Do you have any straight male friends?" Orsi was enjoying taunting me."Do Chaz or Vincent count?" I looked to Pamela."They are straight males, but they don't really know you yet," Pamela failed to be of much help. "I think Vincent insinuated he'd shoot you if you dated any of his three daughters. It was friendly of him to warn you. I supposed that could be construed as liking you.""Are all your acquaintances violent?" Anya seemed worried."Vincent isn't violent. He's with the US FBI," I retorted. Pause. "Okay, he carries a gun and shoots it, he's a law officer. They can do that.""You seem to be stressed," Orsi put an arm around my waist. "Let us ease your worries." Hallelujah!Note: One of History's LessonsIn the last 75 years of military history, airpower had been a decisive factor in every major conflict, save one. Most Americans would think the one exception was US involvement in Vietnam and they'd be wrong: right country, wrong time. Indochina's War of Independence against France was the exception. There, the French Air Force was simply inadequate to the task.Yes, the United States and its allies eventually lost the struggle in Vietnam. But it was their airpower that kept the conflict running as long as it did. For the most part, the Allied and Communist military hardware on the ground were equivalent. While the Allies had superior quantities of supplies, the Communists countered that with numbers, and therein lies the rub.Airpower allowed the Allies to smash large North Vietnamese formations south of the Demilitarized Zone and thus prevented the numerical advantage from coming into play. The North Vietnamese and Viet Cong made one serious stab at a conventional militarily challenge to the Allies, the Tet Offensive, and after initial successes, they were crushed.With the NVA unable to flex their superior numbers, the Allies were able to innovate helicopter-borne counter-insurgency operations. The North Vietnam's Army (NVA) was forced to operate in smaller units, so the Allies were able to engage them in troop numbers that helicopters could support. The air forces didn't deliver ultimate victory, but air power alone had never been able to do so on land. It was only when the US lost faith in achieving any positive outcome in Viet Nam and pulled out, that the North was finally able to overrun the South 20 months later. But every major power today understands the lesson.End of Note(Big Trouble in Little China)The military importance of airpower was now haunting the leadership of the People's Republic of China (PRC), the People's Liberation Army (PLA) and People's Liberation Army Air Force (PLAAF). Their problem wasn't aircraft. Most of their air fleet consisted of the most advanced models produced during the last two decades. The problem was that 80% of their pilots were dead, or dying. Their ground crews were in the same peril. Even shanghaiing commercial pilots couldn't meet the projected pilot shortfall.Classic PLA defense doctrine was to soak up an enemy (Russian) attack and bog down the aggressor with semi-guerilla warfare (classic small unit tactics backed up with larger, light infantry formations). Then, when the invaders were over-extended and exhausted, the armored / mechanized / motorized forces would counter-attack and destroy their foes. This last bit required air superiority through attrition.The twin enemies of this strategy were the price of technology and the Chinese economic priorities. With the rising cost of the high-tech equipment and a central government focus on developing the overall economy, the Chinese went for an ever smaller counter attack striking force, thus skewing the burden of depth of support far in favor of their relatively static militia/police units.So now, while the PLA / PLAAF's main divisions, brigades and Air Wings were some of the best equipped on the planet, the economic necessities had also meant the militia was financially neglected, remaining little more than early Cold War Era non-mechanized infantry formations. To compensate, the Chinese had placed greater and greater emphasis on the deployment capabilities of their scarcer, technologically advanced formations.When the Anthrax outbreak started, the strike force personnel were the first personnel 'vaccinated'. Now those men and women were coughing out the last days and hours of their lives. Unfortunately, you couldn't simply put a few commercial truck drivers in a T-99 Main Battle Tank and expect them to be anything more than a rolling coffin. The same went for a commercial airline pilot and a Chengdu J-10 multi-role fighter. The best you could hope for was for him/her to make successful takeoffs and landings.A further critical factor was that the Khanate's first strike had also targeted key defense industries. The damage hadn't been irreparable. Most military production would be only a month to six weeks behind schedule. But there would be a gap.It was just becoming clear that roughly 80% of their highly-trained, frontline combatants were going to die anyway. Their Reserves were looking at 30~40% attrition due to the illness as well. In the short term (three months), they would be fighting with whatever they started with. Within the very short term (one week), they were going to have a bunch of high-priced equipment and no one trained to use it. With chilling practicality, the Chinese leaders decided to throw their dying troopers into one immediate, massive counter-offensive against the Khanate.Just as Temujin predicted they would. Things were playing out according to plan.Note: World Events SummaryRound #1 had seen the Khanate unite several countries under one, their, banner. Earth  and  Sky soldiers had rolled across the Chinese border as their Air Force and Missile Regiments had used precision strikes to hammer Chinese bases, sever their transportation network and crippled their civilian infrastructure.Next, the frontier offensive units had been obliterated, the cities bypassed and the Khanate Tumens had sped forward to the geographic junctures between what the Khanate wanted and from whence the PLA had to come. In the last phase of Round #1, the Khanate prepped for the inevitable PLA / PLAAF counter-strike.Round #2 had now begun:Step One: Declare to the World that the Khanate was a nuclear power. As history would later reveal, this was a lie, but no one had any way of initially knowing that. Hell, the Khanate hadn't even existed 72 hours ago. Satellite imagery did show the Khanate had medium-range strategic missiles capable of hitting any location in the People's Republic. In Beijing, a nuclear response was taken off the table.Step Two: Initiate the largest air-battle in the history of Asia. Not just planes either. Both sides flew fleets of UCAV's at one another. It wasn't really even a battle between China and just the Khanate. Virtually all of the UAV technology the Khanate was using was Japanese, South Korean and Taiwanese in origin, plus some US-Russian-shared technology thrown into the mix.When the South Korean design team saw the footage of their bleeding-edge dogfighting UCAVs shooting down their PRC opponents, they were thrilled (their design rocked!), shocked (what was their 'baby' doing dominating Chinese airspace?) and anxious (members of South Korea's Defense Acquisition Program Administration, DAPA, were rushing over to chat with them).Similar things were happening in Japan, Taiwan, Russia and the United States. The Communist Party leadership in Beijing were beginning to seriously consider the possibility that everyone was out to get them. Of course, all the Ambassadors in Beijing were bobbing their heads with the utmost respect while swearing on the lives of their first born sons that their nations had nothing to do with any of this.These foreign diplomats promised to look into these egregious breaches of their scientific integrity and were saying how sorry they were that the PLA and PLAAF were getting ass-raped for the World's viewing pleasure. No, they couldn't stop the Khanate posting such things to the internet, something to do with freedom. Paranoia had been creeping into the Potentates' thoughts since the Pakistan/Aksai Chan incident.As they watched their very expensive jets and UCAV's being obliterated, distrust of the global community became the 800 pound gorilla in the room. To add habaneros to the open wounds, the United States and the United Kingdom began dropping hints that they had some sort of highly personal communication conduit with the Khanate's secretive and unresponsive leadership. Yes Virginia Wolfe, the Western World was out to get the People's Republic.'Great Mao's Ghost', all that claptrap their grandfathers had babbled on about (1) the Korea War, (2) the Sino-Soviet grudge match, (3) the Sino-Vietnamese conflict and (4) the persistent support for the renegade province of Formosa all being a continuous effort by the liberal democracies and post-colonial imperialist to contain Chinese communism, didn't sound so crazy anymore.Step Three: Plaster all those PLA ground units that had started moving toward them when the air war began and the Chinese envisioned they would control the skies. The T-99 was a great tank. It also blew up rather spectacularly when it was stuck on a rail car (you don't drive your tanks halfway across China, it kills the treads).As Craig Kilborn put into his late night repertoire:"What do you call a Khanate UCAV driver who isn't an ace yet? Late for work.""What's the difference between me coming off a weekend long Las Vegas bender and a Khanate pilot? Not a damn thing. We've both been up for three days straight, yet everyone expects us to work tonight."Some PLA generals decided to make an all-out charge at the Tumens. Genghis's boys and girls were having none of that. They weren't using their Russian-built Khanate tanks to kill Chinese-built PLA tanks. No, their tanks were sneaking around and picking off the Chinese anti-air vehicles.The Chinese tanks and APCs engaged the dismounted Khanate infantry who, as Aksai Chin had shown, possessed some of the latest anti-tank weaponry. In the few cases where the PLA threw caution to the wind, they did some damage to the Khanate by sheer weight of numbers. For the rest, it was death by airpower.With their anti-air shield gone, the battle became little more than a grisly, real-life FPS game. It wasn't 'THE END'. China still had over 2,000,000 troops to call upon versus the roughly 200,000 the Khanate could currently muster. The PLA's new dilemma was how to transport these mostly truck-bound troops anywhere near the front lines without seeing them also exterminated from the air.After the Tumens gobbled up the majority of the PLA's available mobile forces, they resumed their advance toward the provincial boundaries of Xinjiang and Nin Mongol. There was little left to slow them down. The Chinese still held most of the urban centers in Xinjiang and Nei Mongol, yet they were isolated. And Khanate follow-up forces (the national armies they'd 'inherited') were putting the disease-riddled major municipalities under siege.All over the 24/7 World Wide News cycle, talking heads and military gurus were of two minds about the Khanate's offensive. Most harped on the fact that while the Khanate was making great territorial gains, it was barely making a dent in the Chinese population and economy. Uniformly, those people insisted that before the end of November, the Khanate would be crushed and a reordering of Asia was going to be the next great Mandate for the United Nations.A few of the braver unconventional pundits pointed out the same thing, but with the opposite conclusion, arguing:1.There were virtually no military forces in the conquered areas to contend with the Khanate's hold on the regions.2.Their popularity in the rural towns and countryside seriously undercut any hope for a pro-PRC insurgency.3.Driving the Khanate's forces back to their starting points would be a long and difficult endeavor that the World Economy might not be able to endure.When the PLAAF was effectively castrated after thirty-six hours of continuous aerial combat, a lot of experts were left with egg on their faces. One lone commentator asked the most fearful question of all. Where was the Khanate getting the financing, technical know-how and expertise to pull all of this off? There was a reason to be afraid of that answer.And while I was entertaining my six sailor-saviors, there were two other things of a diplomatic nature only just revealing themselves. Publically, Vladimir Putin had graciously offered to mediate the crisis while 'stealthily' increasing the readiness of his Eastern Military District. If there was any confusion, that meant activating a shitload of troops on the Manchurian border, not along the frontiers of the former nations of Mongolia and Kazakhstan.After all, Mongolia was terribly poor. Manchuria/Northeastern China? Manchuria was rich, rich, rich! From the Kremlin, Putin spoke of 'projecting a presence' into the 'lost territory' of Manchuria, citing Russia's long involvement in the region. By his interpretation of history, the Russians (aka the Soviet Union) had rescued Manchukuo (the theoretically INDEPENDENT Imperial Japanese puppet state of Manchuria) from the Japanese in 1945. They'd even given it back to the PRC for safekeeping after World War II was concluded.Putin promised Russia was ready and willing to help out the PRC once again, suggesting that maybe a preemptive intervention would forestall the inevitable Khanate attack, thus saving the wealthy, industrialized province from the ravages of war. Surely Putin's Russians could be relied on to withdraw once the Khanate struggle was resolved? Surprisingly, despite being recent beneficiaries of President Putin's promises, the Ukraine remained remiss in their accolades regarding his rectitude.In the other bit of breaking news; an intermediary convinced the Khanate to extend an invitation to the Red Cross, Red Crescent and the WHO to investigate the recently conquered regions in preparations for a humanitarian mission.That intermediary was Hana Sulkanen; for reasons no one could fathom, she alone had the clout to get the otherwise unresponsive new regime to open up and she was using that influence to bring about a desperately needed relief effort to aid the civilians caught up in that dynastic struggle. A Princess indeed. No one was surprised that the PRC protested, claiming that since the territory wasn't conquered, any intervention was a gross violation of Chinese sovereignty.End of Note(To Live and Die in Hun-Gray)Orsi may have been the troupe leader, but Anya needed me more, so she came first."I need a shower before we catch some dinner," I announced as we meandered the streets of Mindszent. My lady friends were all processing that as I wound an arm around Anya's waist and pulled her close. "Shower?" I smiled down at her, she was about 5 foot 7. It took her a few seconds to click on my invitation."Yeah, sure, that would be nice," she reciprocated my casual waist hold. Several of her friends giggled over her delay. We were heading back to the Seven Fishermen's Guest House."Do you do this, picking up strange girls you've barely met for, you know?" she said in Bulgarian, as she looked at me expectantly."Yes and no," I began, in Russian. "I often find myself encountering very intriguing women, for which I know I am a fortunate man. I embrace sensuality. That means I know what I'm doing, but I'm not the 'bring him home to meet the parents' kind of guy.""What of your fiancée? Do you feel bad about cheating on her?" Anya pursued me."Hana is wonderful. I've met her father and it went badly both times," I confessed."How?" Anya looked concerned for me."Would you two speak a language the rest of us can understand?" Monika teased us."Very well," I nodded to Monika, and turned back to Anya, "The first time, his son raped a girl and I threatened the young man's life," I revealed. "Jormo, Hana's father, wasn't happy when I did so. The second time, he hit me twice, once in the gut and once in the head," I continued."Why did he hit you?" Orsi butted in."I'd rather not say. You may think less of me," I confessed. Pamela gave me a wink for playing my audience so well. I'm glad she's family (kinda/sorta)."The boy, he is dead?" Magdalena guessed. "Hana's brother?""I really shouldn't talk about that," I evaded. "It is a family matter." That's right. The family that my grandmother had brought me into as her intern / slayer-in-training. There is no reason to create a new lie when you can embellish a previous one."Do you ever feel bad about what you do?" Katalin asked Pamela. We love movies."As I see it, if I show up looking for you, you've done something to deserve it," Pamela gave her sage philosophy behind being an assassin."Are you, bi-sexual?" Jolan murmured. Pamela smacked me in the chest as I laughed. "Did I say something wrong?" Jolan worried. Pamela was a killer."No, you are fine," Pamela patted Jolan's shoulder. "I'm straight and happily so. It just so happens that most of my co-workers are women. Day in, day out, nothing but sweaty female bodies working out, sparring and grappling together, and afterwards, the massages."That was my Grandma, poking all the lesbian buttons of the women around me. Best of all, she did it with the detached air of a sexually indifferent matron. She was stirring up the lassies while keeping them focused on me. We walked into the courtyard of our guest house."Don't take too long, you two," Orsi teased us."Ha!" Pamela chuckled. "That's like asking the Sun to hurry up and rise, the Moon to set too soon, or the sea to stay at low tide forever.""Anya," I whispered into her ear. "How many orgasms do you want?" Anya's eyes expanded. Her eyes flickered toward her friends, then back to me. She held up one finger, I grinned speculatively. Anya held up two fingers. I kissed her fingers.

Cáel saves a spirit and risks losing his soul.By FinalStand. Listen to the Podcast at Explicit Novels.Life gives you two chances to get it right; be who you want to be, or who you need to be.(Making choices we can live with)"Trouble," Wiesława relayed to our vehicle. Velma had an 'issue' at my apartment. She'd gone ahead in order to see to my security. My GL-550 had come within a block of the apartment when Wiesława's call came."Tell me what the problem is," I demanded. Wiesława relayed my request."Your roommate won't let them search your bedroom," was the answer I got back."Fuck that," I grumbled. "Tell Velma I'm coming up. Wiesława, take us to the front of my place." She gave me a cautious look, testing my resolve. Sensing that I'd jump out if I had to, she spoke over her blue-tooth to Velma. She wisely didn't pass on Velma's vitriol at me poking my nose into my SD's business, protecting me.As we pulled up and double-parked, everyone piled out."Are we going to need any "extra" assistance?" Delilah suggested. Considering the flock of 'follow-up' cars and SUV's tailing us, I wasn't overly worried about the law enforcement angle.What was I worried about? It wasn't dark yet on a weekday and Timothy was home. Since Velma would have informed me if he was toting around the Black Death, this had to be a crisis of a personal nature, most likely my personal nature. Wiesława struggled to keep pace with me as I took the stairs three at a time. She'd given up on me letting her go first.At the third floor landing we came across one of Velma's team covering that approach. A second member was at the door and from inside, I could hear Velma cursing in Hittite under her breath. But first,"I really don't think you'll need your sword, Saku," Delilah advised. "Timothy's not that kind of trouble.""Hey Velma, Crewe (who, together with Constanza, I'd sparred with, way long ago) and Timothy," I loudly announced myself just as I stepped in. "What seems to be the problem?" Timothy sighed and gave a head-toss to my closed bedroom door. Since I didn't want to be an asshole, I turned to Velma. "Let me send a neutral party to check things out." I had so many to choose from, Miyako, Selena, Vincent and Delilah.Saku might kill on general principle. Buffy and Wiesława were Amazons and I was beginning to think that Amazons, shit. I sighed, groaned and lowered my head. I looked to Timothy and clapped my wrists together (slave-like). He nodded. Rhada. Mother-puss-bucket! What was I going to do?"I've changed my mind, Velma, the room is fine," I started off. "I know for a certainty that my life is not imperiled by my visitor. Everyone else, I am about to have sex, so could you please head out to a restaurant and give me an hour, or two?" I took in the rest. Timothy coughed and pointed to the ceiling. "Three hours, " another cough, "four hours." No more coughing."Who is it?" Buffy snarled, lest I forgot that I was her scratching post. She was resenting the lack of scratching going on between us. I was about to tell her I needed some private time,, or just not tell her anything. But I was working on not being a jerk. I pulled Buffy to Timothy's room and gave her the lowdown. She mulled over the information. Her wrapping a hand around the back of my head and pulling me into a steamy kiss was unlooked for."Okay," she smiled. "Please don't think I'm not righteously pissed with the two of you, but I know you are doing the best you can with your limited survival instincts.I'll take care of everyone." Off she went and in moments, the room had cleared out until it was just Timothy and me."She stopped by work this afternoon looking pretty badly beaten up, emotionally," he explained. "I doubt she's slept in three days and she's really confused about all kinds of things. I was in the process of letting her know you weren't going to be back for two more days when the Welcome Wagon arrived.I figured the last thing she needed, before seeing you, was public exposure," he said."Thanks buddy," I hugged him. "A few hundred guys tried to kill me and Aya last night, so we came back early. Now," I steeled myself, opened the door and entered my room. Rhada was at the head of the bed, her knees pulled up to her chin and my pillows stacked up around her in some sad effort at a visual barrier.Her eyes had a sunken quality to them that suggested someone two steps past hopelessness. She was waiting for me to say something, which was an added truckload of bad news in my book. I began to undress in an unhurried manner. The shirt came off. Working the belt free came next."I've missed you," I said in a calm, yet positive manner. No response.I finished undressing while she remained frozen and emotionally clouded. I made some semi-educated guesses. Her mind was probably an incomprehensible cyclone of clashing upbringing principles and adult desires. She didn't need to be built up, Rhada needed to be rescued. That kind of emotional crisis was something I didn't need, or want, at this moment in my life.Rhada had nowhere else to go. Her martial bravery was of no use in the matter of her heart's insistent call. Her fear was of a different nature. She was looking down that unholy, dark corridor that was the last walk of all failed Amazons. She craved her personal slavery to a man and master. It was tough to move farther away from her native culture than that, or so she thought."Have you missed me?" I asked with authority. I ran two fingers along her left jawline. Rhada nodded. It was a rather feeble effort. "I asked you a question.""Yes," she sniffled."I am curious why you are hiding your body from me, Rhada," I prodded her. I wasn't 'curious'; I was peeved and she knew it"I don't know why I'm here," she moaned."Oh, " I mused. I was on her like lightning.She struggled weakly as we rolled around until she was ass-up on my lap. I had her right arm pinned to her back. Two sharp blows rained down on her covered posterior. Just two for now."I asked you a question. We both know your answer was inadequate," I spoke softly. Two more stinging, open-handed slaps to her buttocks. "I have defeated you in battle," two more smacks. "I have repeatedly taken you by force as my captive," two more with her accompanying moan."What makes you think you can defy me now, Rhada?" The promised blows did not fall. "I own you, don't I?" She moaned wantonly from anticipation of the spanking that wasn't coming. The lesson was simple: punishment and reward were mine to dispense, not for her to demand."I'm sorry," she mumbled."The incompetent are sorry, failures are sorry, useless people are sorry," I stated, followed by two more loud, cupped-hand blows on her ass. "People apologize when they commit an error. People apologize if they plan to learn from their mistakes. Now, are you someone else's miserable excuse for a human being, or are you MY person who learns from her lapses in judgment?""I bring shame to my people," she whimpered. Two more smacks fell upon her backside."Why do you insist on insulting me, Rhada?" two more, far harder, spanks landed causing her to gasp in pain. "Of all the Amazons I have defeated, I picked you to be mine, captive, no other. I thought you had the fierce spirit worthy of my fighting prowess.Your crawling up and dying inside disappoints me," I continued. It didn't disappoint me; it scared me. Rhada was so fiery and feisty. Seeing her mentally ground down into a crippled state ate at my mind."I'm afraid, Cáel," she choked out between her tears.The emotional riptide she was going through caused her to shake uncontrollably. I telegraphed my intent to move her, face down, to the middle of the bed. As I straddled her, I dragged her hands over her head and crossed her wrists. I nuzzled her shoulder, the crux of her neck, and ear."What are you afraid of, my captive?" I murmured.The term 'captive' along with the gentle affections brought forth a pleasurable response from her."I am perverse," she whispered. "I want you to take me as I cry and scream. I want to feel your body pressing down on me as you are doing now.I beg to be spanked, lashed, tease and tormented by you. Steal my sight and hearing. Render me helpless and utterly at your mercy, my Cáel," she pleaded. I'd allow the 'my'."And?" I mused."And?" she was confused."I was waiting for you to request something perverse, something I wouldn't do to you," I explained. I punctuated that by pulling her shirt aside and biting down on her shoulder strong enough to leave deep indentations on her flesh."Aha!" she yelped. She still wasn't making the connection, how incredibly stubborn of her."Do you doubt my bravery?" She didn't respond, so I bit into and worried her left earlobe. "Do you doubt my dedication to the Host?""No," she moaned. "You are an excellent warrior.""So we both agree I have earned the right to take you as my captive," I teased her."This is why I find your insolence to be so confusing," I kept up my routine. "It is almost as if you would rather be bound, whipped, beaten, spanked, bitten, lashed, covered with hot wax, blindfolded, and gagged instead of giving me my due obedience." Rhada's deep sensual moan was what I had been looking for. She spread her legs slightly then pushed her ass against my crotch."I am yours," she sniffled slightly. "You defeated me in battle and I can expect no other fate.""Dates take off their clothes. Slaves strip before their masters," I related. Not true. I had enjoyed multiple stripteases in my time and even give a few. What Rhada wanted to know was that I hungered for her naked flesh."You are on top of me," she protested. I pulled her braid to the side and chomped down her right shoulder. That earned me another squeal. Rhada's initial efforts were frantic, inspired by her pain. Within seconds she recalled our shared moments and slowed down. She knew I liked to watch her clothes come off and go back on. I'm odd that way.I rewarded her obedience with alternating kisses and nips to her freshly exposed flesh. As we progressed, Rhada became more insistent for sexual attention. Her finely honed thighs and abdominal muscles ground her buttocks against my cock in a continuous, circular motion. In our current state, she couldn't get her pants and panties off.When I rolled off, Rhada shot me a worried look. First she flashed up fear because she mistook my look for one of anger. In a second, she keyed to my real mood. I was going to own her, stretch her to her limits and then take it one step further. I was going to use my war captive as I saw fit, rip my pleasure from her passion and break her doubts down to their foundations.She shimmied out of her remaining clothing. I rummaged up the appropriate toys with a bit of an amused snort. Odette had organized the 'toy box' (including a bill for 'modernizing and updating' of my equipment.) What girl does that for a guy, categorize sexual aids she knows you are going to use on other women in your life?"Loosen your braid," I directed her after I turned and soaked in the view. She was in the center of the bed, kneeling with her buttock resting on her heels. Rhada's hands rested just above the knees, her great brown eyes had more of their old spark to them. Part of that was caused by my words sinking into her psyche. The rest was her love affair with my physique.Me and all my scars, plus I had a new one for her to judge and appreciate."Small caliber round from a Seven Pillar's QCW-Type 05," I informed her. Amazons loved their weaponry and their martial exploits."Did you kill him?" she asked with her intensity overcoming her attempt at a demur nature."Him and a bunch of other guys," I chose to answer as she unbraided her silky, black hair that cascade down to the small of her back. I was the son of a Chicago working stiff, not some super-soldier."You fought for the Host and killed our enemies," she tried to ease my mind.I wanted to feel bad about what had happened. The horror I had inflicted would never go away."Most of them were burned alive," I enhanced her experience by ripping open my own, fresh mental scar tissue. For Rhada, ruthlessness, martial valor and battlefield accomplishments were their own aphrodisiac.In her translation of events, her captor had proven yet again he was a fearless, masculine champion, a lion-heart. I put one knee on the bed and waited. Rhada had to shuffle to me. It was interesting to see the magnetic effect of the three items I held in my casual grasp, a leather collar, a thin silver-coated chain and a pair of leather handcuffs. I motioned with the cuffs first.I left it for her to discern my intention. I wanted her to put her wrists forward, yet I wanted to train her to know my wishes. Not only would it keep her mind and perceptions occupied, it would give her a needed sense of learning and broadening her education. It was a very subtle narrowing of the eyes that I used to tip her off.She half-turned with her wrists at her back, caught my 'displeasure' and then extended her arms toward me. I cuffed her right wrist, then her left wrist and finally cinched them together with their two bronze links, all the while demanding she retain eye contact with me. With our silent measuring of our true grit, we established our positions.Without that clash of wills, everything else would be tawdry trinkets of no value. As she accepted those bonds, she set aside her willingness to challenge me and embraced our new sense of harmony. A corner had been turned. Submission became the only outcome her destiny allowed. Mamitu; the Amazon belief that the Goddesses put nothing before the sisters that experience hadn't prepared them for.Out of arrogance, she had struck me. Destiny had prepared me for the fight and I had won. In tribute to destiny, Rhada had acknowledged the lesson and was finally learning from it. I yanked her wrists up roughly until they were extended high over her head. Rhada kept them there, as I intended, because now was time for the collar.This time she couldn't keep her eyes from flickering to the device until it passed beneath her chin. With the cuffs, I had been deliberate and relentlessly purposeful. The collar was an easy gesture, me exerting my rights as her captor and master, nothing more. I spared her a smile. Her dark brown-olive complexion, nearly black around the areola and nipple, was extended by the raising of the arms overhead for my viewing pleasure.Lastly, there was the chain. It had clasps at both ends, so I hooked it around the single ring on the collar and pulled Rhada toward me. I feasted on her lips, touched tongue to tongue inside and outside our mouths, and ended up chewing her lower lip. As I pulled and plucked it with my teeth, my fingers began to coax a stiffening of her teats.Gentle caresses turned into vigorous touching that evolved into painful pinches between the thumb and forefinger and energetic plucking. I let my kisses migrate from her lips to nose (briefly) then her cheeks and the underside of her jawline. Rhada made a gasping-choking noise as I nibbled her flesh.My distraction must have worked because she missed my hands moving down. The middle and forefinger of my left became a wedge working between her buttocks. With the right, I led with my middle finger, using my fore- and ring-fingers to part her labia. The clip-rings of the chain were secured on each thumb.Her fluids turned her sex into warm molasses coating folds of molten tenderness. My solo probing finger didn't penetrate, not yet. I ran the length of her vulva vestibule, rubbing her vaginal and urethral openings. Rhada expressed a piteous whine as I stoked her sexual frustrations. I ratcheted up my torture when my left twin fingers reached her sphincter.Tap the opening, tease her with false penetrations. My lips reached her neck right beneath her ear. I pulled in the flesh with a powerful suction, grabbing the tiny tip of taut flesh with my teeth. Her dolorous pleading ramped up as I delved my fingers in simultaneously. Rhada's anal ring pulsed, alternating between ushering my forefinger inside and resisted my progress.I was breaching her defenses without lubrication. It was wiggling, tentative advancement on my part and sensations of extreme sensitivity on her part. By comparison, her vagina virtually sucked me in. Having been denied sex for so long (if you counted two weeks as long) all the while fantasizing to the point of tripwire anticipation, she was quickly rising to orgasm."Do not," I cautioned her. Rhada trembled. Her groans became guttural as she reached down into her physical conditioning to exhibit some control over her racing heart rate and labored breathing. Had I stopped my assault, she might have held out. I didn't. The task for us both was to push her past the point of control. She was going to lose, that was given.How she lost was the lesson. What level of stimulation was going to be too much? She fought it with every fiber of her being. She fought it for me. Rhada sweated profusely and vibrated like a gypsy tambourine. She could not win. She knew I never intended for her to win. But I wanted her to reach down deep and fight.She would fail and I would punish her for her failure, but it would be a punishment that she felt was well-deserved, and she craved that. Even her failure was part of our dynamic, captor and captive. Pain with a purpose. Pain as a thread that united us. She could not wound herself the way I could. Everything she could inflict, she would sense and prepare for.I provided torment from unexpected angles and stimuli in a myriad of forms. Everything faded until only the touch and the pleasure of the messenger remained."Urah, " her opening declaration of the overwhelming tide was animalistic and desperate.For fifteen seconds I continued to play with her as her climax turned upon itself, building and becoming more chaotic. In the back of my mind, I realized my sex play was being cruel to my neighbors. I had to hope the anonymous death threats would keep Mr. Fiennes at bay.I'd deal with my 'friendly' female neighbor later, once I figured out how to repay her for her patience and the cookies she'd sent over when I was ill. For Rhada, it was a temporary cessation of my sexual attention and allowing her to rest her body against mine. I admired her ability to hold her arms aloft. Still,"You failed," I whispered into her ear. Rhada hiccupped. I dragged my fingers covered with her cunt juice up her pubic mount, abdomen, around the belly button and between her breasts. At the conclusion of the trip was the resounding 'click' of that end of the leash being attached to her collar. "I don't think you have been humble before me."I looped the chain around her shoulder, then dragged it over her left breast. She shivered. My next stop was beneath her right breast. Her nipple seemed to swell up as I rubbed the other loop all over her areola. Next under the right mammary, then looping the chain around her right arm before reaching around the back and securing the second clasp.It was both a symbol of her captivity and body ornamentation. The shiny silver links contrasted with her dusky, sweaty flesh.

Mon, 20 Jan 2025 04:45:00 +0000 https://jungeanleger.podigee.io/1937-borsepeople-im-podcast-s17-01-andrea-benckendorff 42668034edb2cf9520ad67fc04d7d4a3 Andrea Benckendorff ist seit Sommer 2024 CEO vom Season-Presenter EXAA Energy Exchange Austria und ich war für die Startfolge der Season 17 zu Besuch bei der EXAA im Palais Liechtenstein. Ich spreche mit Andrea, die man als Pionierin der Energiemarkt-Liberalsisierung vor etwas mehr als 20 Jahren bezeichnen kann, über ihren abrupten Einstieg und das Entwerfen der Initial-Verträge für die Branche als Juristin. Freilich stellen wir auch die EXAA, ihre Delikatessen und ihre Rolle in Europa vor, zudem werden APCS, AGCS, ÖMAG und Cismo eingereiht. Und es geht auch um eine durchzechte Nacht, die Reinigungsbranche, einen technischen Frankreich-Schock im Sommer, Pluralität, Sonne und Regen sowie Spoiler zu Fabienne Scheucher (dann S17/05) und Zsolt Janos (S17/02). https://www.exaa.at Börsepeople Wolfgang Aubrunner CCPA: https://audio-cd.at/page/playlist/6697 Börsepeople Kalina Jarova Müller CCPA: https://audio-cd.at/page/playlist/6701 About: Die Serie Börsepeople des Podcasters Christian Drastil, der im Q4/24 in Frankfurt als "Finfluencer & Finanznetworker #1 Austria" ausgezeichnet wurde, findet im Rahmen von http://www.audio-cd.at und dem Podcast "Audio-CD.at Indie Podcasts" statt. Es handelt sich dabei um typische Personality- und Werdegang-Gespräche. Die Season 17 umfasst unter dem Motto „25 Börsepeople“ 25 Talks. Presenter der Season 17 ist die EXAA (Energy Exchange Austria) https://www.exaa.at. Welcher der meistgehörte Börsepeople Podcast ist, sieht man unter http://www.audio-cd.at/people. Der Zwischenstand des laufenden Rankings ist tagesaktuell um 12 Uhr aktualisiert. Bewertungen bei Apple (oder auch Spotify) machen mir Freude: http://www.audio-cd.at/spotify , http://www.audio-cd.at/apple . 1937 full no Christian Drastil Comm. 2335

In this episode of the Pints and Polishing Podcast, hosts Marshall and Nick discuss the challenges of detailing in winter conditions, the importance of interior cleaning, and the evolution of cleaning products in the detailing industry. They explore the risks associated with using concentrated products and the shift away from traditional all-purpose cleaners (APCs) towards newer, safer alternatives like Revive. The conversation highlights the need for detailers to adapt to changing product quality and the importance of understanding the materials they are working with. In this conversation, Marshall and Nick delve into the intricacies of surfactants, the debate between concentrated and ready-to-use cleaners, the importance of quality in cleaning products, and the necessity of proper panel prep for ceramic coatings. They emphasize the balance between cost, time, and quality, and share personal anecdotes to illustrate the impact of these choices on business and customer satisfaction. Takeaways Ice skating in Vegas is a new experience. Winter detailing requires creative problem-solving. Focus on interior detailing during cold months. Quality control in car manufacturing is declining. APCs can be harmful to modern plastics. New cleaning products are emerging in the market. Detailers need to adapt to changing materials. Revive offers a safer alternative to traditional cleaners. Understanding product ingredients is crucial for detailers. Dealerships heavily rely on APCs for cleaning. Understanding surfactants helps in making better product choices. Grades of surfactants indicate their harshness and suitability for different tasks. Time spent on diluting products can add up, affecting overall efficiency. Quality products can save time and provide peace of mind. The cost of saving on cheaper products can lead to significant losses in business. Proper panel prep is crucial for the effectiveness of ceramic coatings. Using the right panel prep can prevent damage to paint finishes. Many detailing products contain oils that can affect coating adhesion. It's important to follow manufacturer guidelines for product use to maintain warranties. Investing in quality products can enhance customer satisfaction and business reputation. Chapters 00:00 Introduction to the Podcast and Current Events 01:53 Winter Detailing Challenges 05:59 Interior Detailing Insights 09:57 The Evolution of Cleaning Products 19:52 Comparing APCs and New Cleaning Solutions 21:04 Understanding Surfactants and Their Grades 22:57 The Debate on Concentrated vs. Ready-to-Use Cleaners 27:10 The Cost of Quality: Time vs. Money 32:01 Panel Prep: Why It Matters for Ceramic Coatings

Episode 999 of Another Prank Call Show.In this episode Richard defies middle age by engaging once more in comedic irrelevancy. In a world where Amazon offers health insurance, Walmart employees wear body cameras, and trash covers everything from Mount Everest to the Mariana Trench, Richard refuses to surrender to the notion that life is a prank. Instead he soldiers on with prank call premises that are perhaps slightly less absurd than reality has become, but somehow even stupider. Is this new episode worth the wait? Should Richard have let this show recede into the dustbin of history, like his hairline, health, and positive view of the world? Perhaps these questions will linger, unanswered, for all time. Or at least until the grid goes down and APCS finally, blessedly, vanishes forever.For the best APCS listening experience, add the RhonkCloud Archive RSS feed to your podcast app: https://apcs.rhonk.cloud/feed.xmlOr use the Internet Archive, because it will surely last forever: https://archive.org/details/anotherprankcallshowAPCS stickers, keychains, and for some reason CDs are available for purchase: https://anotherprankcallshow.com/trashCheck out the APCS website.Email the show.Like and subscribe on YouTube.Vista Blue makes cool songs for the show, but you should listen to all their awesome music.World of Prank Calls is a cool website where you can find a wealth of information on lots of other prank call podcasts, and maybe learn a thing or two about making your own.Check out Snow in Southtown.APCS would not exist without the decades of inspiration from the PLA or the tireless support of Olga.All music by seven.© 2024 Porcelain Phone Productions

Guest Juan Pablo Alperin | John Willinsky Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard discusses the importance of maintaining open access to research with guests Juan Pablo Alperin and John Willinsky from the Public Knowledge Project (PKP). The conversation covers PKP's history, the development of their open-source software, Open Journal Systems (OJS), and its impact on scholarly publishing. They dive into the integration with other open-access initiatives, the role of AI in future projects, and the challenges faced in balancing sustainability with the rising demands of their growing user base. The episode also touches on community-driven translations and the importance of creating equitable access to knowledge, especially for communities in the global south. Download this episode now! [00:01:20] John explains PKP's commitment to open access, starting in 1998 with the goal of making research publicly available. [00:02:35] Juan describes Open Journal Systems (OJS) as the flagship open source software of PKP, which facilitates research publication worldwide. [00:04:57] The conversation touches on the peer review process, the importance of making scholarly knowledge open, and how PKP encourages open access through their platform. [00:07:44] John and Juan explain how OJS allows academics and institutions to manage the entire publishing process, from submission to peer review and publication, while maintaining the integrity of research. [00:11:54] John discusses the intersection of open source and open access, noting the successes and challenges that remain in the fight for free and equitable access to research. [00:13:52] Richard inquires about where the funding is coming from, and Juan explains. [00:16:49] The guests highlight how commercial publishers have embraced open access, though often in ways that perpetuate inequalities, such as through article processing charges (APCs). [00:21:09] The discussion touches on sustainability, both in terms of funding PKP and the broader scholarly ecosystem, and the risks of commercializing access to knowledge. [00:25:23] Translation and localization efforts are discussed and how PKP's platform supports multiple languages, enabling access to knowledge across diverse linguistic communities. [00:31:42] The challenges of integrating non-Western and indigenous knowledge systems into scholarly publishing is discussed. [00:35:57] Juan and John share the hurdles PKP faces in terms of keeping up with community demand and ensuring long-term sustainability. [00:39:41] Find out where you can learn more about the projects online. Quotes [00:12:20] “This was going to be Rhetware, that is, it was rhetorical.” [00:13:07] “Open access is close to 50% of the research in the world that's published this year will be freely available to the public and researchers everywhere.” [00:14:55] “An important part of our sustainability is that we provide hosting services for the software.” [00:36:40] "As the community has grown, so have the demands and expectations of the project.” Spotlight [00:41:07] Richard's spotlight is Kawawachikamach, Quebec, [00:41:54] Juan Pablo's spotlight is the project, pandas. [00:42:31] John's spotlight is Mattermost. Links SustainOSS (https://sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) richard@sustainoss.org (mailto:richard@sustainoss.org) SustainOSS Discourse (https://discourse.sustainoss.org/) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) John Willinsky LinkedIn (https://www.linkedin.com/in/john-willinsky-714a1b241/) Juan Pablo Alperin Mastodon (https://mastodon.social/@juancommander) Public Knowledge Project (PKP) (https://pkp.sfu.ca/) Public Knowledge Project (PKP) Community Forum (https://forum.pkp.sfu.ca/) Public Knowledge Project (PKP) GitHub (https://github.com/pkp) Open Journal Systems (OJS) (https://pkp.sfu.ca/ojs/) Kawawachikamach, Quebec (https://en.wikipedia.org/wiki/Kawawachikamach,_Quebec) pandas (https://pandas.pydata.org/) Mattermost (https://mattermost.com/) Copyright's Broken Promise: How to Restore the Law's Ability to Promote the Progress of Science By John Willinsky (https://direct.mit.edu/books/oa-monograph/5507/Copyright-s-Broken-PromiseHow-to-Restore-the-Law-s) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guests: John Willinsky and Juan Pablo Alperin.

How is the automotive industry meeting the lofty government goals that new diesel and petrol cars and vans will no longer be sold from 2030, and that all new cars and vans must be fully zero emission at the tailpipe from 2035? Will Stirling interviews Ian Constance, CEO of the Advanced Propulsion Centre Often mere words do not do the task justice. The transition to net zero automotive – think about that for a minute. The easy part is to visualise switching powertrains from petrol and diesel to electric (EVs), then designing and building processes for the mass volume manufacture of EVs – a huge engineering challenge. But this complexity covers materials, batteries and gigafactories, electric machines and drives, rare earths, power electronics, fuel cells, and more, such as their supply chain viability. Then there is the charging and hydrogen fuelling infrastructure. Supply chain security of key materials, including rare earth materials mined in just a few global locations, R&D investment in the right areas, technology scale-up, geopolitical risk, and market reaction to new technology. An important actor in this complex landscape is the Advanced Propulsion Centre (APC), the government agency tasked with managing funding programmes, judging applications and assisting companies that have good, low-carbon tech solutions. The APC administers the Automotive Transformation Fund, a £1bn+ fund to help eligible companies make the low carbon transition. It has run a suite of projects, funds and accelerator programmes since 2013. CEO Ian Constance needs to juggle all these balls, and the clock is ticking, but he spared 30 minutes for MTD magazine. Ian says: “The Advanced Propulsion Centre (APC)'s mission is to enable the UK to stay at the forefront of the global transition to smarter, safer, and importantly, more sustainable automotive and mobility solutions. The other part of APC is Zenzic, an agency investigating future-related, autonomous mobility – driverless vehicles.” What are the net zero automotive trends as we head towards 2025? “In the last 12 months, we've gone from a position of very high growth to flatlining and a bit of stagnation in the EV market, so what you're seeing there is a shift back towards HEVs (hybrid) and PHEVs (plug-in hybrids). I believe that is a short or medium-term shift and is driven by a few factors including rising populism in politics. But given the money and plans put into getting to net zero, we will find our way back to growth in BEV, battery electric vehicles. MTD readers are interested in the net zero automotive shift generally, and in manufacturing opportunities specifically. Recently the APC produced a report on the electric motor market, and the change in motor technology – indicating there is a slow shift from the dominance of permanent magnet synchronous motors to non-magnet motors like induction motors. Do both provide good opportunities for UK engineering businesses? “We have some very capable businesses that are scaling up here,” says Constance. “One of them is AEM, Advanced Electric Machines, based in the Northeast, who are developing magnet-free motors. In general, we have a very strong traction motor community in the UK comprised of various companies that are developing tech in this space, and a lot of them are using magnetic rare earth materials. There is Yasa in Oxfordshire, Protean in the Southwest who specialise in in-wheel electric motors, and there are plenty of others as well. So, the motor manufacturing opportunities are massive for the UK.” “Ford is investing heavily in Halewood, with support from the APC. They are turning this big factory from a manual transmission plant, clearly a technology that's intimately linked with internal combustion engines, over to electric drive units at high volume for export. Ford is doing that because it sees the UK as an important place to put that technology and create that mass volume.” “On the motor technology shift: Permanent magnet motors are generally high performance and are lower cost (than rival tech) at this stage. They need rare earth materials. The non rare earth magnet motors, and non-magnet motors (induction and electrically excited synchronous motors), are an important hedge against the volatility of rare earth material prices and supply, which is expected to go through the roof. That volatility and the geopolitical angle is a hedge that that many people want to make sure that they're on the right side of.” Rare earth reliability, and gigafactories for specialist vehicles A big, less visible part of the APC's work is research and policy work into securing these essential materials. As rare earth supply is dominated by China and a handful of countries in much smaller volumes, supply security is paramount. “You need to mine the ore, the raw stuff, in a clean and sustainable way, then you have to process the materials into rare earths, then into magnet materials, produce magnets, which are then used in the motor – it's a classic supply chain, with risks. We (the UK) are looking to create those supply chains back to friendly nations that we feel we can make long-term strategic partnerships with. The processing part of it is as important as the availability of the materials.” The mainstream net-zero automotive news has been dominated by gigafactories, so-called in reference to the capacity of the batteries made there. Building these factories in countries that manufacture EVs is essential, due to the dollar and carbon costs of shipping batteries, plus these are vast investments, and create thousands of jobs and supplier contracts. The UK's gigafactory picture is, some might say, behind its European peers following the loss of Britishvolt in 2023. Constance contests whether Britain is far behind the pack. “We (the UK) had the first gigafactory in Europe, a small one in the Northeast with just over one gigawatt hour (GWh) that supports the Nissan Leaf. Yes, the UK footprint is confined to two new massive gigafactory commitments, one which is Envision AESC and linked to Nissan, and the second is Agritas, part of the Tata Group, in the Southwest. Look at the potential of those two facilities, they could jointly produce over 70 GWh of battery cells. Our forecast is that by 2030 we will need around 90-95 GWh, so we are well on our way to fulfilling these requirements. “But these things are never that simple, are they? Two of our biggest vehicle manufacturers, Nissan and Jaguar Land Rover, will be certainly supported by those two gigafactories. We will need more to look after some of the bigger carmakers, but also very importantly, specialist vehicle manufacturers, which is such a strength of the UK; sports cars, luxury, and heavy-duty vehicles and off-road machines – all of those are going to need a supply of batteries. If people need a specialist vehicle, they might want a specialist battery. So getting into that specialist battery domain is a real focus for the future.” With batteries also come materials, and lithium is the primary base material for battery anodes and cathodes. But lithium, like rare earths, has a limited supply chain. “There are several different flavours of lithium battery. Beyond that, sodium is the next best element, but it has limitations. We are going to be dominated by lithium, particularly in the UK that has medium-to-high mass production vehicles. That's where the attention should be.” Hydrogen's changing role Hydrogen has had an interesting story. It was the wonder material for about three years, then media interest seemed to cool as the hype cycle shifted. How is it now developing in the UK car market? “We are increasingly asked to fund and look at projects involving hydrogen and hydrogen propulsion, much of that is around fuel cells,” says Constance. “Some of it is around hydrogen combustion that's more suitable for off-highway and construction.” “The APC's view is that fast forward another 10 years, most light-duty vehicles (vans and cars) will be battery electric. Then medium-duty trucks will have a mixture of battery electric and potentially hydrogen fuel vehicles, and for heavy-duty, long distance 40 tonners, etc – there's a big case for hydrogen combustion there.” There are three legs to this stool: the availability of the technology on the vehicle to do the job cost-effectively and efficiently, the availability of the infrastructure to support the delivery of whatever the energy medium is – hydrogen or electricity. And the third bit is, making the conditions right for the market. You need the three legs together.” Finally, what other manufacturing opportunities are there for subcontract companies in the EV transition? “Three areas, I'd highlight,” says Constance. “Giga-castings is a rising area of light-weighting and efficient vehicle manufacturing. Tesla reimagined the way cars are built by using massive front end and rear end castings rather than spot welding or bonding aluminium sections together. Can we develop more of that? Also the design of drives shafts is changing for an EV powertrain. There is growth of driverless pods operating in in secure space or in semi-secure space like airports. This is a step in completely reimagining a vehicle into lightweight, highly manoeuvrable modes of transport. Although these are complex machines, the barriers to entry here are lower than for developing a mass-market vehicle.”  

Today's episode features a guest host, Michael Upshall, Community and Outreach Manager at Core, who talks with Peter Suber, Senior Advisor on Open Access, Harvard Library and Director of the Harvard Open Access Project Peter Suber, one of the best-known figures in open access, discusses his background and involvement in the open access movement. He explains how he became infatuated with open access and left his tenured professorship to work on it full-time. Suber also discusses the importance of the Budapest Initiative, which defined open access and identified strategies to achieve it. He shares his views on APCs (article processing charges) and the role of repositories in delivering open access content. The conversation covers various topics related to open access, including the challenges and improvements in open access repositories, the role of mandates in promoting open access, the impact of preprints, and the connection between open access publishing and research misconduct. It emphasizes the need for continued education and awareness about open access and the importance of addressing misunderstandings. The conversation concludes with a discussion on the future of open access and the ongoing work needed to promote good business models and policies. Social Media: LinkedIn: https://www.linkedin.com/in/mupshall/  Keywords: #harvard, #OA, #OpenAccess, #OpenInnovation, #OpenEntrepreneurship, #Access, #PublishingIntegrity, #ResearchIntegrity, #PoweringResearch, #knowledge,  #efficiency, #innovation, #awareness,  #career, #partnerships, #collaboration, #scholcomm, #ScholarlyCommunication, #libraries, #librarianship, #LibraryNeeds, #LibraryLove, #ScholarlyPublishing, #AcademicPublishing, #publishing, #LibrariesAndPublishers, #podcasts

In this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can lend insight when it comes to taking a bioindividual approach to supporting the immune system. Topics: 1. Introduction - Explanation of HLA gene variants - Importance of HLA genes in immune system function 2. Basics of Genetics and Immunology - What is a chromosome? - Introduction to genes and their functions - Overview of DNA and protein synthesis 3. Major Histocompatibility Complex (MHC) - Description of the Major Histocompatibility Complex - Division of MHC genes into Class I, II, and III - Role of Class I MHC genes in antigen presentation - Role of Class II MHC genes in antigen presentation - Function of Class III MHC genes 4. HLA Genes and Immune Function - Explanation of Human Leukocyte Antigen (HLA) genes - Connection between MHC genes and HLA genes (human MHC) - Transcription and regulation of HLA genes - Response to internal and external signals - Role of Antigen-presenting cells (APCs) 5. Pathogen Recognition and Immune Activation - Mechanism of pathogen recognition by HLA genes - Activation of immune response by antigen presentation - Formation and function of peptide-HLA complexes 6. Impact of HLA Variants on Disease - Specific focus on Lyme disease and mold toxicity - Role of HLA Class II alleles in immune response - Association of HLA-DR alleles with chronic Lyme disease - Sensitivity to mold exposure linked to certain HLA gene variants 7. Testing and Implications of HLA Gene Variants - Importance of HLA gene variant testing - Broader implications for diseases like lupus and multiple sclerosis - Personalized approaches based on HLA gene variants 8. Biotoxin Illness and Poor Antigen Presentation Due to an HLA Gene Variant - Strategies to support immune system function in the presence of biotoxins - Importance of detoxification pathways and binders Thank you to our episode sponsor: ⁠⁠⁠⁠⁠Liver Medic⁠⁠⁠⁠⁠⁠ Use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠⁠⁠⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode we're joined by editors from Cell, Nature Reviews and Molecular Oncology to discuss the process of scientific publishing: from the steps involved, including the peer review stage, to choosing the best home for your research; from preprints to peer-reviewed journals; from APCs and how to get a discount to the importance of engaging in an open conversation about your research with editors even prior to your paper submission.

For Review:1.  US Gaza Pier Needs Repair.  The pier will be pulled from the beach and sent to the southern Israeli city of Ashdod, where U.S. Central Command will repair it.2. IDF continues investigation into the deadly fire that occurred after a strike on two Hamas commanders in Rafah. IDF suspects that munitions or some other combustible substance caused a secondary explosion and a fire to spread in a complex housing displaced Gazans.3. IDF Pushes Tanks into Central Rafah. IDF tanks were spotted near Al-Awda mosque, a central Rafah landmark, the witnesses said.4. Report: IDF Using Unmanned M113 APCs in Rafah ground campaign. 5. Spain and Belgium provide commitments for future military aid to Ukraine.6. Switzerland to host Ukraine Peace Summit from 15-16 June 2024. Russia not invited.7. Sweden's Air Force wants long-range missiles and more personnel.8. Sweden brings increased naval capability to NATO via vast submarine experience and an increased focus on sea bed warfare.

Find me and the show on social media @DrWilmerLeon on X (Twitter), Instagram, and YouTube Facebook page is www.facebook.com/Drwilmerleonctd   FULL TRANSCRIPT Wilmer Leon (00:00:00): As I'm sure most of you know by now, according to Iran State Media, Iran's President Ibrahim Raisi, the country's foreign minister, Hussein Amir Abdulah, have died in a helicopter crash. There are a number of questions that this unfortunate turn of events presents. Was this simply an unfortunate accident as their helicopter traveled in dense fog along Iran's border with Azerbaijan, was the helicopter taken down? What's next for Iran? What's next for the region? Announcer (00:00:43): Connecting the dots with Dr. Wilmer Leon, where the analysis of politics, culture, and history converge. Wilmer Leon (00:00:51): Welcome to the Connecting the Dots podcast with Dr. Wilmer Leon. I'm Wilmer Leon. We have a tendency to view current events as though they occur in a vacuum, failing to understand the broader historical context in which most events take place. During each episode of this program, my guests and I have probing, provocative and in-depth discussions that connect the dots between the events and the broader historic context in which they occur. This enables you to better understand and analyze these events that impact the global village in which we live. For insight into these issues, let's go to Beirut Lebanon. Let my guest, he's an award-winning broadcaster and independent journalist based in Beirut Lebanon. He's a policy consultant with the Community Media Advocacy Center, and you can find him and his work at Free Palestine dot video. He's Laith Marouf Laith. As always, welcome back. Laith Marouf (00:01:53): Thank you for having me. It's always a pleasure to be with you. Wilmer Leon (00:01:56): So let me start with who was former president Ibrahim Raisi. The western media describes him in less than glowing terms as a religious hardliner. He's seen as a potential successor to Supreme leader Ayatollah Ali Hamani. He was a former judge and allegedly a member of what the West calls the death commission, which forcibly disappeared and traditionally executed in secret thousands of political dissidents. Those are the allegations who was former President Ibrahim Raisi. Laith Marouf (00:02:41): Well, definitely he was part of the first generation that lived the Islamic Revolution and were on the front lines during the massacres that Iraq and the West commissioned in Iran, the use of chemical weapons against Iranians paid for by the Germans and the us. So he has that credential of living that revolution, and he was a judge and the accusations that are keep on being repeated there of thousands of prisoners being executed, we're talking about the terrorists that are part of the Mujah, the MEK terrorist organization that was housed in Iraq and funded by the West and is now housed in Albania that was responsible for the killing of almost 70,000 people in Iran through their terror campaign. That includes the killing of ministers and the government officials at the time. So the accusation against him is that he crushed the vessels, the terrorists that work for the CIA, that's his accusation against him and otherwise he was a judge and very respected within the country because of this background. Actually, whatever accusation that the west has against him as a discrediting thing, in reality, it is a positive thing for his reputation in Iran because of how he defended Iran against the terrorist. (00:04:31): The hype that we saw over the last month or so in the media about Rasi being going to be the next ayatollah after Hamina steps down, that there is no truth to that in terms of any speaking of that in Iranian society or Iranian media. In fact, we should take it as an indicator of that he was going to be assassinated. There's something that say it has the Sid Hasan Astra, the Secretary General of Hezbollah after the assassination of General Soleimani in 2020 by Trump. So Sid Hasan Asra a speech. He spoke about how when the media in the West suddenly gives attention to a leader in the region out of the blue and start giving them very high stature, that is maybe true, but it's not. That's an indicator of an assassination coming and that he spoke to General Soleimani the day before he was assassinated while he was in Beirut about that and warned him as he was flying to Baghdad on a domestic flight that this is actually even more worrisome that he was on a domestic flight given all this attention. So now we see kind of the same thing happening here, all this hype being pumped about Raisi in the month before the assassination, specifically since the retaliation of Iran against the assassination of its diplomats in the Damascus. So I see it as actually an indicator that he was going to be assassinated and now that's what actually happened. Wilmer Leon (00:06:26): To your point that this was an assassination, there are a couple of things that as soon as I heard that the helicopter went down that came to mind. One was, was it taken down? Apparently there were three helicopters flying in formation and his helicopter was one of the three, and it seems as though it just dropped out of the sky. They keep talking about the terrain, they keep talking about the fog. I know some US military trained helicopter pilot certified helicopter pilots. The first thing I did was call them and ask them when you heard fog, when you heard terrain, when you heard the helicopter went down. I said, what's the first thing that came to your mind? They all said, oh, they took that thing out the sky and they said, first of all, they all said to me as certified pilots, we would never have crashed our helicopter. That just was not going to happen short of some catastrophic mechanical failure. They said, which by the way, we are trained to deal with. They told me the quality of pilots that they have in Iran that those pilots, they say this goes all the way back to when Iran was an ally of the United States during the Shaw's time and that the protocols that were in place then are many of the same protocols that they follow today. (00:08:03): So there was a lot of information opinion that they gave to me, which said, and then they even mentioned, you got to understand the MEK along that region, that Azerbaijan is an ally of Israel or that there are elements within Azerbaijan that are so connect some of those dots for me please. Are these just the opinions of Ill-informed individuals or they said for the fact that the thing dropped out the sky without it, even a mayday call indicates that something was wrong here? Laith Marouf (00:08:43): Yeah, I mean, you mentioned a lot of important things. So first off, obviously there was no made call as you said. So we don't have any information about some problem happening on the helicopter. The other is that there was two other helicopters with it and they continued to reach their target and destination and they reached it. That's the question also, why didn't they stop and fly back and look for the other helicopter? That's a big indicator that there's something wrong that happened there that is not just a regular crash. The other thing is that the Iranian government took a very long time to really show us what happened and tell us that Rasi and his companions were dead. In fact, the hours after the crash, the Minister of Internal Security told the whole world that they received two calls from survivors on the plane, on the helicopter, and later on all the way around 2:00 AM PA on time, again, the minister of internal claim that they received a call from one of the crew members on the helicopter all the way that late saying that they were hearing the ambulances or the sirens in the area. (00:10:13): So while all of this was happening, the minute the helicopter crash was announced and called a soft landing, and then it took so long, I mean, this is Iran that has satellites. This is Iran that has drones that can fly and reach Israel and hit their targets thousands of kilometers away. I thought in my mind that either from the first minute that Raisi and his team were assassinated and they're dead, and the Iranians were delaying the announcements so they can tidy up their house and prepare for the transition and think about what they want to do if there's an actual assassination or that the Iranians were hiding the fact that he was alive and they were just milking it for support. This is what I thought during the whole night as they were doing this search, and obviously for them to finally tell us they're dead, that's in me confirmed that there was an assassination. (00:11:21): None of the stories that came from the Iranian government to the media during the quote search made any sense. And so now we know they're killed. I believe the Iranian government knows that they were killed and how they were killed, and I think given the fact that the Israelis have a tendency of assassinating political leaders as retaliation for their failures on the battlefield, this is historic. Look at how even recently, look at how they assassinated Hamas leadership in Beirut because they were failing on the ground in Gaza and they failed in the battle with Iran after they targeted the embassy in Damascus and Iran landed a huge blow on them and they were not able to retaliate. So their only usual behavior is to assassinate political leaders, and that's what we saw. The question is because Netanyahu attempted last month when attacking the embassy to drag the United States into a war because he sees Israel losing the battle on the ground. (00:12:47): He sees that Israel cannot even fight Hezbollah if a bigger war starts with Lebanon. He needs the United States to be around on the battlefield with him. He wanted to drag Iran into that war with the attack on the embassy, and they didn't retaliate in a way that created a war. And now he did this to try to drag again Iran into this war. But this is not what Iran wants. Iran has a clear plan with the access of resistance that we're seeing unfold over the last seven months, which is to chisel away at Israel slowly and cook it like a frog, a live frog boiling where it collapses internally, where all this support from the world collapses externally, and there's no need for a war for this Zionist colony to collapse, but Netanyahu wants a war. So I think the Iranians are not going to admit that this is an assassination because if they admit this an assassination, they have no choice but to carpet bomb the hell out of the Zionist colony, and that would derail the plan and will take it to the stage that Netanyahu wants it. So I think they're going to just bite the bullet and continue on their set plan and will not be dragged into, it's very sad. I mean, it's very sad that this is going to be what's going to happen, but that's the only thing path forward I see. Otherwise, if Iran decides to retaliate, we're going to be in World War three immediately. Wilmer Leon (00:14:24): And I think it's important for people to understand that there's a much longer term vision here, that the axis of resistance, they have a different worldview. We know that if the situation were reversed and either if somebody had shot an Netanyahu's playing out the sky or if this had happened to Tony Blinken while he was traveling in the region, that the bombs would be exploding by now. But I think there are economic concerns here that those in the region are taking into account war. As I said to Godfather, war is messy business war is very expensive. And with their economies under sanctioned, with their now finding ways to move and operate without the sanctions to go into a war right now, whether it's the Russian economy, whether it's the Chinese economy, whether it's the Iranian economy, they don't want that economic stress on their economies. They also know that I think going into a World War which, or at least a regional conflict, would shut off oil transport through both the Red Sea and the Persian Gulf, which would then collapse the world economy. They don't want do that. I don't think I'm conflating their concern for world welfare. I think they're looking much, much longer. Am I connecting some dots here? Laith Marouf (00:16:04): Yes, yes, you definitely are. And although most of the access of resistance and China, Russia, and most of Africa and Latin America want to see an end to American imperialism, no one wants the whole world to burn in the process. Okay? It's no one's interest to have a World War. People want to clip the wings of the United States, bring it back to its natural size, and the same thing for Europe and balance humanity. There's no interest in these countries to see the United States burn and Europe become a wasteland. And so there's the difference. The difference is people in the south and the East just want the foot of America off their neck. They don't want to put their own foot on America's neck. And so we will see, as we are seeing right now, both in the battlefield in Ukraine, or what's happening around Taiwan or what's happening here right now in the Western Asia battlefield is the constant attempt by the access of resistance and others around the world to take things slow, to allow time to be the biggest weapon. Wilmer Leon (00:17:33): Hence the adage. You have the watches, we have the time. So with all of this, what's next for Iran? Laith Marouf (00:17:43): Yeah, I mean, we already know that they have to have an election within 50 days. That was announced yesterday, and the current vice president was appointed as temporary president until elections happen. Iran as a constitutional democracy will fill these positions as fast as possible, even though these individuals leave a huge gap behind them because of their knowledge and portfolios. abd Ian being the youngest foreign affairs minister of Iran's history, and because of his relations in Africa and Latin America and Rasi with the relationships that he built. So where should expect that this is going to happen this election. But look at one thing, the Israelis, at least what they got from this is at least now a distraction for the next three, five days in Iran and World News while they intensify the massacres in Gaza and in the West Bank last night, for instance, eight people were killed in Janine, so Palestinians. (00:19:06): So there's a lot that we can't really predict what's going to happen. The other thing is that it's very possible that Iran, although they don't announce that this was an assassination and that they don't put the finger on Israel, that they actually conduct clandestine actions that are in kind and something nasty happens to some Israeli official, and nobody can say who it is. So those are possibilities. But I think the most probable thing is that Iran will try to stay the course that the support fronts in Lebanon and Yemen will intensify rapidly to a different level. Wilmer Leon (00:19:49): That's my next question. What happens in the region? Laith Marouf (00:19:53): Yes. Yes. So we're already seeing an intensification even before this assassination. We had a change in the tactics on the Lebanese front with Hezbollah conducting multilayered complex operations that include drones, guided missiles, and achieving huge hits. Much of the air defenses that Israel has downing two huge surveillance balloons. One of them is the biggest in the world, this Zeppelin balloon, there's only two of them in the Zionist colony, one around the Una reactor, one in the north. And the Israelis had put this one in the north because of the destruction of all of their surveillance equipment on the border with Lebanon. So to see Hezbollah not only down these drones, but also film the after from, sorry, not only down these balloons, but also film with surveillance, drones after effect of the destruction and coming back with their images, 100% high HD 4K images of the, so we're already passed into a new stage now in Lebanon, and I expect it to only intensify. And similarly with Yemen, I think that in the next 24 hours, we will see Yemen starting to attack shipping in the Mediterranean, and that will add another sea under Yemeni sovereignty. It's not only going to be the Red Sea, the Arabian Sea, and the Indian Ocean, you'll have also the Mediterranean, and that will be the smartest thing that Iran can do with the access of resistance is to intensify the battle on these fronts without addressing the issue of the assassination of Raisi. Wilmer Leon (00:21:55): When we look at the recent dynamics, and what I mean by that is if we go back to October 7th, in fact not even that, I'm sorry. What I mean is China gets involved with the Saudis, the Saudis wind up talking to Iran. There's reproach mom between Iran and the Saudis haven't heard much from the Crown Prince Ben Salman. In all of these most recent developments, are there things coming out of Saudi Arabia that are not being reported in the West, particularly now as it relates to the death of former President Raisi? And is Bin Salman concerned about his longevity? Laith Marouf (00:22:54): I think everybody is right now worried about their longevity. We've seen the assassination attempt on the Czech president, so we saw the attempted coup, all of this within 24 hours in Congo. Again, American Israeli mercenaries trying to overthrow the president of La Congo. So we're right now entering a new stage in the global battle, not only in Western Asia, we're seeing the West do the maximum they can with the hybrid war. So it's not only a media war, it's not only a sanctions war, it's not only direct confrontations or military confrontations. We're seeing these assassinations and cos and so on, intensified by the United States and its vessel states. So the Saudis issued an official statement condolences to Iran on the assassination. In fact, all of the Gulf countries, Kuwait, Bahrain, Qatar, Emirate, Oman, Saudi, all of them send their condolences. There is three days of mourning in Lebanon, in Syria, in Iraq, in Pakistan, in India, and in Tajikistan and in Turkey. And this is things that are unheard of. Maybe it was expected as Syria or Iraq, but Lebanon and Pakistan and Turkey, this is so we can see that the whole region is worried about the results of this assassination. What does it also mean to, what are the rules of the game now? What is allowed to be done? Because if you are allowed to assassinate presidents now, this means there's no rules. Wilmer Leon (00:25:05): Lemme just quickly say to that point, that reminds me of a comment that President Putin made maybe a year ago as people were talking about, oh, is Russia going to assassinate the president of Ukraine? And Putin said, no. He said, no, no, no, we don't do that. So people need to understand that there's a, I hate to use it. There's a decorum, there's a protocol. There are certain things you're not supposed to do even in the rules of war, even in warfare, you don't assassinate the leader of your opposing country. So you are making that comment just made me think about the point that Laith Marouf (00:25:57): By the way, president Putin is on the way right now on the flight to the Harran, and he's flying with escorts of Soho 35 to the Harran, and he will be there tomorrow during the funeral procession led by the Illah. Wilmer Leon (00:26:19): What is that signal? In my mind that's huge because that's huge on a couple of fronts. One, his country is in the midst of a conflict with NATO slash the United States slash the West. So he must feel incredibly comfortable to leave as he did when he went to China in the midst of this conflict. I can leave my country. I'm not concerned about a being assassinated. I'm not concerned about something happening domestically. B, he's flying into a war zone. He's flying into a country whose president was just killed, many believe assassinated. So on a number of fronts, that to me speaks volumes. Laith Marouf (00:27:07): Yes. And there's the ICC arrest warrant Wilmer Leon (00:27:10): Against that too. Laith Marouf (00:27:11): It's the National Criminal Court. So we know that yesterday, the minute the announcement was made that the crash happened, the President Putin called in the ambassador of Iran to Moscow into almost a six hour meeting with all the heads, the intelligence military in foreign affairs of Russia. It was like a special kind of war council almost. And we don't know what happened in this meeting. So what information did Russia share with Iran? What are their points that were made in that meeting? And immediately we see this visit by President Putin being confirmed, and he's flying over the Caspian Sea directly into Iran from Russian territory to Iranian territory with the military escorts. We will clearly that this indicates a lot of things. And he's flying with him the top cater of the Russian military intelligence and foreign affairs to Iran. So there's something that's going to happen there. (00:28:34): We don't know what's the exchange that's going to happen in these meetings. And to go back to the issue of assassinations, the access of resistance members have never assassinated any Israeli leadership. Not because they can't. In fact, the only time that there was any assassination of an Israeli official is the Minister of settlements during the second in the Father in 2002 was conducted by the popular front for the liberation of Palestine in retaliation for the assassination of the leader of the PLFP AB mufa when the Israelis fired missile from a helicopter into his official office. So historically, the axis of resistance does not do assassinations like this. Why? Because number one, and this is true for Russia, by the way, number one, our enemies don't have any heroes. They only got lunatics, stupid leaders. And if you kill them, Wilmer Leon (00:29:42): You martyr them. Laith Marouf (00:29:43): You create the martyrs, right? The Israelis, Wilmer Leon (00:29:48): You inflate them to an artificial sense of value in power. Laith Marouf (00:29:56): Exactly. So there's no need to create martyrs for the Ukrainians or the Israelis. These are all goals. They should never be allowed to reach that status of martyrdom. The second issue, and this is true again for Ukraine, is because we're gifted as an axis of resistance. And Russia is gifted with the stupidest kind of enemy. Why would you want to kill Zelinsky if he's so dumb? Or Netanyahu is making so many stupid mistakes. If you kill them, maybe somebody smarter will come, you'll be even cursed. And in fact, if you look at the Israelis assassinating over and over, leaderships in the axis of resistance, every time they assassinated somebody, somebody even more cunning and more ready to fight them, gets into the position. Look at Hezbollah. Say Hasan came into his position as Secretary General after the assassination by Israel of Del Mu, the former First Secretary General of Hezbollah who was very moderate, soft spoken. And then you get sala and look at what so assassinations don't work on those two grounds. So it's a stupid thing that the Israelis did, this assassination of sei, and it's just going to bring somebody more in power. And now Iran has a president as a martyr on the path of liberation of Palestine. What glory does Iran have? No other nation lost a president in defense of Palestine, not even the Palestinian authority. You see, Wilmer Leon (00:31:49): You're laying out. That logic also goes back to some fundamental organizational constructs, as in organizations that are personality led versus organizations that are structurally led. So what I understand you to be saying is that this resistance is not based upon the personality in charge, that there is a structure here. There is an ideology here that, as we've said a number of times on a number of shows, you can't kill an ideology with a military. You can only defeat an ideology with a better ideology. And so you can assassinate all the leaders you want to, but there are people right behind them that are waiting to take charge. Laith Marouf (00:32:48): Yes, it is institutionalized. Obviously, we don't want to undermine the human factor, like a human factor is very important in all of these things. And people's personalities and connections make a difference. And so yes, these losses are always big, but because of this institutionalization, hopefully the, and because of the actual human factor, this new person that will fill, will bring new openings, new connections with them. Yes, the human factor is very important and institutionalization is as important. Wilmer Leon (00:33:28): Switching gears a bit, the ICC, the International Criminal Court is seeking arrest warrants for the leader of Hamas, Yaya Sanir, as well as the Israeli Prime Minister Benjamin Netanyahu on charges of war crimes, crimes against humanity. And it seems to be centered around the October 7th retaliation by Hamas on Israel. President Biden has denounced as outrageous the request for these warrants. Biden has said, let me be clear. Whatever this prosecutor might imply, there is no evidence none between Israel and Hamas. Biden said that this is a false equivocation. A couple of things. One, people need to understand that the ICC, the prosecutor is seeking arrest warrants. No warrants have been issued yet. I also find it interesting that they are tying all of this back to the October 7th response by the resistance as though October 7th is actually the beginning of something as opposed to the continuation of something. And then I'd like to get your take on, as I understand international law, the actions taken by Hamas on October 7th do not violate international law because Hamas is, Hamas represents the occupied, Israel is the occupier. And in international law, the occupied can do anything in its power to resist occupation. There is no right to defend oneself when you are the occupier. Laith. Maro your thoughts on that analysis? Laith Marouf (00:35:35): Yeah, I mean, I agree with everything that you said, and I would add to it, can you imagine if during the Vietnam War, Vietnam was, and the Vietnamese resistance were taken to the international criminal court and their leadership were declared terrorists for defending themself against French and American occupation, or the Algerian resistance being called terrorists at the ICC for defending themself against the massacres of the French or the French resistance against the Nazis Wilmer Leon (00:36:13): Or the A NC in South Africa Laith Marouf (00:36:15): Or the A NC? So I personally think the collaboration is Palestinian Authority on purpose launched this case at the ICC because they wanted the leadership of the resistance in Hamas to be charged with war crimes. Okay, Wilmer Leon (00:36:43): Wait a minute. Start that again because man, I never saw that one coming. Start that one again, please. Laith Marouf (00:36:52): Yes, yes. I know it's sometimes hard for people to make these connections, but you see there's never been, that's why Wilmer Leon (00:36:58): You're wrong. Connecting the dots. Laith Marouf (00:37:00): Yes. There's never been in history international criminal court case of the occupied taking their occupier into court and the occupied being charged with crimes against their occupier. And it was the Palestinian authority that pursued this case. Okay? And I think it was done on purpose by Abbas Wilmer Leon (00:37:29): Mah. Abba did this Laith Marouf (00:37:31): Mahmud, Abba and his collaborationist goons to dirty the reputation of the resistance to make their resistance equal to the crimes of the occupier. Okay? And I add to it even more the these arrest warrants against Netanyahu and Ganz, who's going to actually enforce them? No Western country will stop Netanyahu from flying over its airspace or landing on its territory, that's for sure, 100%. But you know who's going to be a target? It's a smile Nia, who's sitting in Qatar, right? SSIR and Aldi are in Gaza. The Israelis can't even kill them or assassinate them. They can't reach them, let alone try to arrest them for ICC charges. But smile, Nia, the head of Hamas in foreign political borough is now the number one target. He's probably right now running to find a place that he can hide than Qatar, because Qatar is a vessel state, and they will hand them over to the Americans at any moment. Okay? So in reality, this is one of the worst things that ever happened to the Palestinians. This ICC case, there's nothing to celebrate about it. And if you notice the limitations of this case that it only, as you said, starts October 7th, Wilmer Leon (00:39:03): They don't mention genocide, Laith Marouf (00:39:05): Okay? And not only that, the case is only for crimes inside Ga Gaza, none of the historical Palestine, west Bank, east Jerusalem, any of that will be included in this. And this is not only to protect Israel from accusations of apartheid and the settlement building that is one of the biggest war crimes possible, but also to hide the fact that all these internment camps that have been built since October 7th, were thousands of Palestinians from the Gaza Strip were abducted and sent into these Guantanamo and being tortured, raped, and killed on mass, disappeared completely, because nobody even knows that they're in this. And the fact that VE turned all the Israeli prisons into that same model, 12,000 Palestinian prisoners since October 7th, have been living in these internment camps, tortured, raped, and killed with hundreds, hundreds of testimonies of rape and torture by men, women, and children coming out of these dungeons. And if you notice the docket of these requests for arrest warrants, this house, slave Han, who is a puppet of the United States and Israel, who came as a replacement to the ICC chief prosecutor before him, who got humiliated and death threats and banned from entering the United States and so on, because she even dare thought about charges Wilmer Leon (00:40:56): Even his family was under. Yes, Laith Marouf (00:40:58): Yes. So now, what does this guy do? If you look at the charges when he's talking about Hamas crimes, he speaks of them as if they're facts that rapes happen. We have no, Wilmer Leon (00:41:17): No evidence Laith Marouf (00:41:18): Any rape that babies were killed. No evidence, no evidence killed. But when he talks about the crimes of the Zionist, Wilmer Leon (00:41:27): He uses a minute, just to that point, going back to President Putin, I remember him saying, if you have evidence of these crimes, please show the world. He was very emphatic on that point. You have made these allegations. If you have evidence, please show the world. And no matter how many times Joe Biden, no matter how many times Tony Blinken wants to talk about these atrocities, they've never even pierce Morgan. I know you saw the interview with Dr. Morandi and Pi Morgan, where Morandi just cut him a new one. He said, Pierce, where's the evidence? And Pi Morgan just kept chatting, just kept chirping. Go ahead, I'm sorry. Laith Marouf (00:42:30): Yes, yes. I mean, the evidence is like you have to take the word of the chosen people for fact. What are you antisemitic, Wilmer. You don't believe every word that comes out of a chosen person mouth. I mean, that's it. That's all evidence you need. So Wilmer Leon (00:42:48): If I was antisemitic, I wouldn't be talking to you. Laith Marouf (00:42:50): Exactly. Exactly. But we're joking about it. But truly, this guy, this sock puppet had, he went down to Israel after October 7th and sat down with the families and unquote survivors, and visited the colonies that were attacked, but refused to enter Gaza Amass, opened the door for him, invited him to come and see Joe evidence, the war crimes. He refused to go to Gaza, okay? And then now he's coming and he's writing in his docket that these crimes happened by Hamas. But when he's talking about the crimes accusations against Israel, he says reasonable grounds before every accusation he is already, you could see how tainted this case is and what is its ultimate goal. I mean, yesterday, the spokesperson for the American government, I can't remember his name, the thin white guy. He was being interviewed, sorry, asked in the question period about this issue, and the guy claimed that the Palestinians have no right to go to the ICC and that their only courts that have jurisdiction are Israeli or American courts. He wants the Palestinians to come and beg at American courts, which even shows you how Israel is a colony, a vessel of the United States. But yes, this is where Wilmer Leon (00:44:32): Matthew Miller, Laith Marouf (00:44:35): Yes, Matthew Pillar, and people call him Matthew Killer. Yes, Wilmer Leon (00:44:38): Right. Matthew Miller. Laith Marouf (00:44:39): Yeah, yeah, yeah. Wilmer Leon (00:44:42): So I'm sorry, I interrupted you. You're saying he was saying that they need to come to American courts? Laith Marouf (00:44:47): Yes. That they have no right to go to the ICC, and the only place that has jurisdiction is the US or Israel over crimes in Gaza, Wilmer Leon (00:45:00): Which is also very telling in that the United States is not as signatory to the ICC, but seems to want to either use it when it's convenient or condemn it when it's convenient. But in fact, excuse me, there's a standing American law, and people can look this up, that if an American is brought before the Hague, the United States reserves the right to invade it. I might even be called the Hague Invasion Act. I'm drawing a blank on the name, but people, folks, you need to look this up. The United States has a standing American law saying, we will invade the Hague if an American is arrested and held accountable for crime. Laith Marouf (00:45:59): Yes, it's ally known as the Hague Invasion Act. And in fact, if you look at the ICC record, 42 out of the 42 people that were convicted of crimes at the ICC were African African leaders, and then add to it that the charges against President Putin. So this ICC is the most captured, un affiliated organism captured by the West, along with the International Atomic Energy Organization and the Chemical and Weapons Organization. These are the least trusted three organs of the un. And we're seeing, I believe these indictments, or if there is an arrest warrant issued, I mean, I don't see anything good coming to the Palestinians from this. Wilmer Leon (00:47:08): Wow. That's a perspective and a level of analysis that I did not see coming. But what you're saying makes sense. Bring us up to date, please on what's happening in Rafa. According to the new Arab, there are by 1.4 million Palestinians there. And that around the 7th of May, they were told that they had to leave. And the number I see is about 80,000 people have fled, but there's, I guess a slow boiling Israeli incursion into the area. What's going on in Rafa now? Laith Marouf (00:48:02): Yeah, I mean, the Israelis are doing what they call belts, fire belts. It's like bombardment from the land, from the sea, from the air on straight lines, and then going next straight line and so on. This is what they've been doing since last week. They haven't yet attempted invading Rafa. They have been stuck in Jabal since last week in the longest and fiercest battle on the ground of Gaza since the beginning of the war. The Israelis lost, according to their own media, at least 10 officers there. That includes a field general, the highest ranking military officer on the field of any army, and along with all his commanders. So we've seen the videos come out from this Jabali battle every day, two or three videos coming out from Hamas, Islamic Jihad and others that showed us tens of Israeli tanks destroyed APCs and bulldozers. So they're receiving a beating, a whipping in the battlefield of Jabal. (00:49:21): So I don't think they're going to invade RA anytime soon. They'll continue bombing from the air. But this has also happened at the same time as yesterday or the day before the Americans finished building the pier, right? Right. And we already now have images of this spear with American air defenses, radars and tanks and ABCs waiting in the landing ships. So clearly the sphere is not about delivering any aid, and it's definitely not about the mass expulsion of Palestinians. This is an invasion, beachfront landing zone in the case of total collapse of the Israeli military on the battlefield. And that's what we are seeing right now happening. Wilmer Leon (00:50:11): And is it a coincidence or should we connect dots that the pier was completed right around the same time that it was announced that, what was it, 1.2 billion more of weaponry has been approved. And so is that a coincidence or am I wrong to connect these dots? Laith Marouf (00:50:34): No, it's not a coincidence. It's also not a coincidence that it was finished the day they assassinated rasi. You see, all of these are time things. It's same thing. It's not a coincidence that the sock puppet Han announced the ICC arrest warrants at the same day of the assassination. So all of this is clearly timed together, and we now saw in the last 48 hours, the cards of the West put on the table, have opened. Now their hand, they just opened their hand with these three moves. The Wilmer Leon (00:51:15): But wait a minute, president Biden is calling for a ceasefire. How can this be true? Laith Maro, when President Biden, when he was at Morehouse giving his commencement address, he's calling for a cease fire. Help me understand this, because obviously you didn't hear him. And so now that you understand, Joe Biden wants to cease fire, how can everything that you've just said be true? Laith Marouf (00:51:44): Isn't it one of the most disgusting things that Biden could do is to lie to the black students and the administration of the university say that he will not use their black faces in his promotional materials for his election? That was one of the conditions to allow him to speak to the students who were going to demonstrate. But because their administration found a middle ground and told them, okay, you can demonstrate without, Wilmer Leon (00:52:15): Don't make any noise, shut Laith Marouf (00:52:16): Down, don't make any noise, and so on. And this guy is not going to use your faces for his election. And now he goes around and immediately, immediately releases a promotional video of using these students to try to get sympathy from the black communities in America. This is, and obviously anybody that believes American leaders should go and ask the indigenous people about all the treaties and their promises. I mean, there's 400 years of record of broken promises and broken treaties. There's not one treaty I think the United States ever abided by with anyone. Have Wilmer Leon (00:53:04): You seen this Washington Post article from last week? The Washington Post reported about a WhatsApp chat stream where New York mayor Eric Adams was chatting with a number of American multimillion and billionaires, such as the former founder of Starbucks and the CEO of Dell and a number of other financiers where they were demanding that Eric Adams send the NYPD into Columbia University. They offered campaign contributions, they offered to fund private investigators to look into the students. And he is now, of course, denying that this took place. But the Washington Post has the transcript of the WhatsApp communications, and they named these individuals by name. And it seems as though their whole concern or motivation behind this is they're losing control of the narrative. Your thoughts, lath maus. Laith Marouf (00:54:21): Yeah. I mean, it's 100% a fact that this happened. No matter what the mayor says, who was another sock puppet? And if me and you have enough money, we can buy American politicians if we want to. They're very cheap. They'll sell you their mamas if you have enough money. Okay? So it's not a surprise. It's actually great that it got leaked, and I'm sure the Washington Post only published it because it was going to be all around the internet anyways, and they needed to have a scoop to stay on top of the story. But this is the truth. The political class and the economic elite are abusing the police in the United States, abusing the power they have over the police, forcing the police to become political police, to suppress the students and the communities that are demonstrating for the liberation of Palestine. I mean, I watched these images over the weekend. The beatings that the NYPD was giving to these youth was, I mean, very similar to who Wilmer Leon (00:55:36): Were peacefully protesting, Laith Marouf (00:55:37): Peacefully protesting, being jumped and taken to the ground and punching women in the face while having your legs on their necks. I mean, it is very similar to how they treat on a daily basis, the black community, specifically black men. But now we're seeing it on a daily scale of people not being accused of any crime or just speaking out or demonstrating. And that's what was happening to the black community in the sixties and the seventies and or the Black Lives Matter movement during the Obama years. Now we are gearing up to this summer of discontent all across the west as these youth finished their exams in the universities and pour into the streets. And we should expect maximum suppression from the political class, and they will be abusing the police to do so because they can't use the courts. Look, in Canada, there's been now two court cases where Zionist students went to court to try to force the police to remove a student encampment from McGill University in Montreal. (00:57:01): McGill University is the Ivy League University in Canada, and they lost. The judge said, no, the students have a right. And then the university administration itself appealed and went to the court to also asked the court to tell the police to remove the students. And again, the court said no. And therefore, this is what's happening. The Zionists in Canada were stupid enough to think that they can win this in court. They thought like, oh, we have all the media, we have all the politicians. We can rip apart the Bill of Rights in Canada. But the Zionists in the United States are a little bit smarter. They know that if they go to court First Amendment, they cannot remove these students. Therefore, they skipped all the legal process and went immediately into abusing their access to power by moving the police, setting them like dogs on the students. Wilmer Leon (00:58:03): Laith Maro, my brother. As always, I got to thank you for joining me today. And let me reiterate to folks that they need to go to Free Palestine video. Go to Free Palestine video. You can see if you could quickly just explain to the audience what you're doing there on the ground, real time in Beirut with free Palestine video. Laith Marouf (00:58:33): So yeah, as a volunteer community television, we're teaching youth and students to produce content in English. We're also doing everyday almost reporting from the south of Lebanon, from the Warfront exclusive coverage of what's happening there, interviews of people on the ground. And we're doing weekly episode of a special show called Wartime Cafe with the biggest intellectual and political leaders in Lebanon in English. Last time, the last episode of wartime Cafe was with Ibrahim Al Mu, who is a member of Parliament, but also the former spokesperson for Hezbollah. He hasn't spoken in English media for a long time. So this is the kind of content that you will get. Please support us donations. We need membership. If there's possible, so people subscribe for monthly donation, that will be amazing. And you can add on our website, free pass. Send the video. You have the links to all our socials, so Twitter, telegram, Instagram, YouTube, brumble. Please watch the content and help us through donations. Wilmer Leon (00:59:49): My brother, my dear brother, lathe Maru, thank you so much for joining me today. Laith Marouf (00:59:54): Thank you for having me. Wilmer Leon (00:59:56): Look forward to having you back. Folks. Thank you all so much for listening to the Connecting the Dots podcast with me, Dr. Wimer Leon. Stay tuned for new episodes every week. Also, please follow and subscribe. Please leave a review, share the show, and you can follow us on social media. You'll find all the links below to the show description, contribute to this effort if you can. Nothing is too small and we know nothing is too large. We greatly, greatly appreciate the contributions that are helping to keep this program on the air. Remember, this is where the analysis of politics, culture, and history converge because talk without analysis is just chatter, and we don't chatter here on connecting the dots. See you again next time. Until then, I'm Dr. Wilmer Leon. Have a great one. Peace. I'm out Announcer (01:00:59): Connecting the dots with Dr. Wilmer Leon, where the analysis of politics, culture, and history converge.

BUFFALO, NY- January 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Effects of resveratrol on in vitro circadian clock gene expression in young and older human adipose-derived progenitor cells.” Observational studies in preclinical models demonstrate age-related declines in circadian functions. In this new study, researchers Sophie G.C. Kapar, Maria F. Pino, Fanchao Yi, Miguel A. Gutierrez-Monreal, Karyn A. Esser, Lauren M. Sparks, and Melissa L. Erickson from AdventHealth and the University of Florida hypothesized that age would be associated with declines in function of cell-autonomous circadian clocks in human tissue. “Accordingly, we cultured adipose progenitor cells (APCs) from previously collected white-adipose tissue biopsies from abdominal subcutaneous depots of young (Age: 23.4 ± 2.1 yrs) vs. older female participants (Age: 70.6 ± 5.9 yrs).” Using an in vitro model, the researchers compared rhythmic gene expression profiles of core clock components, as an indicator of circadian oscillatory function. They observed consistent circadian rhythmicity of core clock components in young and older-APCs. Expression analysis showed increased levels of some components in older-APCs (CLOCK, CRY1, NR1D1) vs. young. The team also investigated resveratrol (RSV), a well-known longevity-enhancing effector, for its effects on rhythmic clock gene expression profiles. They found that RSV resulted in gained rhythmicity of some components (CLOCK and CRY), loss of rhythmicity in others (PER2, CRY2), and altered some rhythmic parameters (NR1D1 and NR1D2), consistent in young and older-APCs. The observation of detectable circadian rhythmicity retained in vitro suggests that the oscillatory function of the cell-autonomous core clock in APCs is preserved at this stage of the aging process. “RSV impacts core clock gene expression in APCs, implicating its potential as a therapeutic agent for longevity by targeting the core clock.” DOI - https://doi.org/10.18632/aging.205292 Corresponding authors - Lauren M. Sparks - Lauren.Sparks@AdventHealth.com, and Melissa L. Erickson - Melissa.L.Erickson@AdventHealth.com Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205292 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, circadian clock, circadian rhythm, adipose-derived progenitor cells, resveratrol About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

O Brasil bate recordes de exportação de carne suína sem parar, embarcando mais de um milhão de toneladas desde 2021. Produz mais a cada ano e fez o consumo per capita passar de 20 quilos. E o país vai ser o terceiro maior exportador mundial, deixando o Canadá para trás. O Papo de Prateleira conversa sobre o tema com Valdomiro Ferreira Junior, presidente da Associação Paulista dos Criadores de Suínos (APCS) e do Consórcio Suíno Paulista. Ele fala sobre o futuro promissor do segmento, a concentração tecnológica da suinocultura paulista, os investimentos em qualidade e tecnologia, a transformação das granjas em ambientes controlados e os mais de dez anos de uma ação inédita: o consórcio que permite a compra em grupo de diversos insumos, fomentando bons negócios, além de fornecedores e produtos de qualidade. Mais informações: Telefone: (19) 3651-1233

Segundo Caracas, mais de 95% dos eleitores apoiaram a proposta de criar a província venezuelana do Essequibo no referendo realizado neste domingo (3). A disputa territorial entre a Venezuela e a Guiana gera tensão na região e preocupa a comunidade internacional. O analista político da RFI, Thiago de Aragão, avalia que o litígio coloca o Brasil em uma situação desconfortável. Thiago de Aragão, analista políticoA América do Sul tem sido palco de uma disputa complexa entre a Venezuela e a Guiana, centrada em um referendo realizado neste domigno, que poderia resultar na anexação de territórios em disputa. No entanto, essa disputa ganhou uma nova dimensão com a decisão da Corte Internacional de Justiça (CIJ) de se opor ao referendo e a eventual anexação do Essequibo. Além disso, um importante ator internacional, a multinacional Exxon, desempenha um papel crucial nesse cenário.Enquanto o embaixador venezuelano, Carlos Amador Pérez Silva, enfatiza que a Venezuela não tem intenção de invadir a Guiana, as suspeitas de que membros do governo venezuelano estão envolvidos em atividades ilegais, como a exploração de ouro, levantam desconfiança sobre as ações da Venezuela na região. É essencial compreender o contexto interno da Venezuela para entender plenamente a situação.O governo de Nicolas Maduro enfrenta desafios crescentes, incluindo recursos financeiros cada vez mais escassos devido à falta de capacidade de gestão e altos níveis de corrupção. A economia está em colapso, o que leva a um desespero crescente para manter-se no poder.Nesse contexto, a ameaça de invasão à Guiana pode ser vista como uma cortina de fumaça para desviar a atenção da população venezuelana de seus problemas internos. Cogitar uma invasão é uma estratégia desesperada de um governo que luta para lidar com questões econômicas e políticas cada vez mais espinhosas.Capacidade militar: uma comparação desigualAo avaliar a capacidade militar da Venezuela em comparação com a Guiana, fica evidente que a Venezuela possui uma vantagem significativa. A Venezuela tem uma força militar muito maior e mais bem equipada, incluindo um exército consideravelmente maior em termos de pessoal e equipamento. Por outro lado, a Guiana possui uma força militar muito menor em termos de pessoal e equipamento. Sua capacidade de defesa é limitada em comparação com a Venezuela, tornando-a vulnerável a qualquer ameaça militar significativa.A Guiana tem cerca de 3.000 soldados equipados com veículos de combate, enquanto a Venezuela possui um contingente militar muito maior, com aproximadamente 123.000 militares distribuídos em várias ramificações.O exército venezuelano está equipado com uma variedade de veículos militares, incluindo 173 tanques de batalha principais (MBTs), como AMX-30V e T-72B1, bem como veículos de reconhecimento, veículos de combate de infantaria (IFVs) e veículos de transporte de pessoal blindados (APCs).Fator Internacional e a desesperança de MaduroDiante dessa disparidade na capacidade militar, é importante reconhecer que a Venezuela, se desejasse invadir a Guiana, teria a capacidade de fazê-lo. No entanto, o fato de a Venezuela alardear o referendo e a decisão da CIJ de rejeitar a organização da consulta popular indicam que uma invasão não é o caminho escolhido. A comunidade internacional desempenha um papel fundamental em desencorajar qualquer ação militar.Os Estados Unidos e outros países têm se manifestado contra qualquer agressão e em apoio à soberania da Guiana. Essa pressão internacional desempenha um papel significativo em manter a estabilidade na região.Além disso, o papel da Exxon, que é a maior exploradora de petróleo na Guiana, torna a situação ainda mais complexa. A multinacional americana possui seu maior investimento no mundo nesse país. Essa presença maciça da Exxon na Guiana é um fator que coloca ainda mais pressão sobre a Venezuela, por conta da importância estratégica da Guiana para os EUA.Situação delicada para o BrasilNo entanto, a situação também coloca o Brasil, sob o governo do presidente Lula, em uma posição desconfortável. O Brasil é um aliado de longa data de Nicolas Maduro, mas compreende que não há argumentação legítima por parte da Venezuela para realizar tal provocação contra a Guiana. O país se encontra em uma delicada encruzilhada, buscando equilibrar suas relações regionais enquanto defende os princípios de paz e resolução diplomática de disputas.À medida que essa disputa complexa se desenrola, é crucial manter um olhar crítico sobre a situação, lembrando que a desconfiança em relação ao governo venezuelano e suas verdadeiras intenções não pode ser ignorada. A Guiana, nossa vizinha na região, deve continuar a buscar soluções que garantam sua segurança e soberania, enquanto mantém a porta aberta para o diálogo e a diplomacia. A América do Sul enfrenta desafios complexos, mas a busca pela paz e pela resolução pacífica de disputas deve sempre prevalecer.

Still tired and poor from holding up paddles in the Greg Jein auction, David and Ryan get their hands on the catalog for Propstore's London auction, taking place from November 9-12. In a super-duper-sized page-turn, the guys hit the highlights such as the good Alien movies (APCs, Pulse Rifles, mini-armor!) and the bad ones (Covenant), Back to the Future time machine parts, a healthy debate over Batman costume nomenclature, a super-duper Blade Runner collection, whether or not it's OK to want a Clockwork Orange costume, the REST (?) of the terrifying Mario Kirner FT13th collection, Gladiator armo(u)rs, some big brass balls, The Bad's very good fedora, over-priced Indy shirts, reasonably-priced Indy whips, Captain America shields, Iron Man helmets, Books of the Dead!, Books of the Living!, a script that might bring Stanley Kubrick back from the dead, and of course, the epic Anthony Daniels collection. So check your internet speeds, take a chill pill, and download the catalog and the episode! SDAMO - Instagram https://www.instagram.com/propspodcast/ SDAMO - Threads https://www.threads.net/@propspodcast SDAMO - Twitter https://twitter.com/propspodcast?lang=en SDAMO - Facebook https://www.facebook.com/propspodcast/ SDAMO - TikTok https://www.tiktok.com/@props.podcast David Mandel - Instagram https://www.instagram.com/davidhmandel/  

RR The Wire 2300Z October 31, 2023 PRECEDENCE: ROUTINE RRDTG: 230031Z OCT 23ICOD: 223031Z OCT 23CONTROLS: Public ReleaseQQQQBLUF: YEMENI ATTACKS ON ISRAEL INTENSIFY. ISRAEL TAKES HEAVY CASUALTIES, MAKES SLOW PROGRESS IN NORTHERN GAZA.-----BEGIN TEARLINE------International Events-Middle East Front: The first few days of the Israeli invasion of Gaza have resulted in fierce resistance, and slow progress. Video evidence indicates Hamas has regularly and effectively targeted Israeli MBTs, IFVs, and APCs during the advance. Israeli DM Gallant confirms via press conference that IDF has suffered heavy losses, though the exact numbers of casualties/losses is unknown.Missile attacks from Yemen have increased following the declaration of War issued by the rebel-held government sector. It is difficult to determine the effectiveness (or existence) of many of these extremely long-range attacks; many reports of random missile impacts in Israel have been reported without any indication of a point of origin.Earlier today, IDF officials claimed responsibility for a substantial airstrike on the Jabalia Refugee Camp in Northern Gaza. IDF officials claim the strike was targeting one Hamas leader, and many civilian casualties have been reported.Elon Musk's claims of Starlink support for Gaza backtrack as he claims that Starlink will only be provided for Gaza after investigation and permission from the US and Israel is granted. It is unclear as to if connections and internet traffic will be monitored by Starlink to ensure that their services are only being used for humanitarian purposes. AC: Based on these conditions, in the remote chance someone has Starlink in Gaza, it is extraordinarily unlikely to be allowed to function. For information exchange, infrastructure that does not rely on Israeli or American resources would be the most reliable form of communication in and out of Gaza.-Analyst Comments-Israel's battle plan appears to be centered around an invasion of Northern Gaza on all fronts, followed by a southern push to the Sinai. Whether or not Israel will be able to obtain these goals is unclear, as overwhelming rhetoric from Israeli officials has attempted to temper expectations and prepare for a long campaign. Per long-standing Israeli defense doctrine, Israel is likely expecting long-term logistical support from the US, as the IDF has already expended substantial munitions in this war so far. Per IDF officials the Iron Dome missile supply is running low, resulting in prioritizing defensive coverage of heavily populated areas.-----END TEARLINE-----Analyst: S2AEND REPORTNNNN

Last time we spoke about the defense of Finschhafen. Finschhafen was a enormous staging camp for the allies now. The Japanese could not sit idly by allowing such a strategic location to be in allied hands. General Katagiri launched a major counter offensive, kicked off with signal fires from Sattelberg. He sent a force of raiders to try and neutralise some heavy allied artillery, but it ended in failure. Having not neutralised their big guns, the rest of the counter offensive fell to pieces.  The Japanese would officially report 422 killed, 662 wounded. For the Australians they had 228 casualties of which 49 were dead. With the counter offensive done with, the allies now would go back on the offensive. The next large target was going to be the stronghold of sattelberg, but the Japanese were not going to make it easy on the allies. But today we are going to be jumping into some new places. This episode is the invasion of the treasury islands Welcome to the Pacific War Podcast Week by Week, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about world war two? Kings and Generals have an assortment of episodes on world war two and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel you can find a few videos all the way from the Opium Wars of the 1800's until the end of the Pacific War in 1945.  For quite some time now we have been focusing on the New Guinea campaign, such as the offensives against Finschhafen and the Ramu valley. Today we are going to enter a new phase of the Pacific War. With the incoming invasions of the Gilbert and Marshall islands, the Northern Solomons and Western New Britain, General Douglas MacArthur and Admirals Hasley and Nimitz were going to turn up the heat. Admiral Halsey had just seized Vila, Barakoma, Munda and Rendova, gaining their valuable airfields for the forces of General Twinings AirSols to utilise. Within the central Solomons, Bougainville was finally within range of allied land-based aircraft. Lae, Salamaua and Finschhafen were taken, thus Operation Cartwheel would begin a new phase. Back in July, plans were formed for General Vandegrifts 1st Marine Amphibious corps to seize airfields sites at Buin and Kahili, the important Japanese anchorage at Tonolei Harbor, and the Faisi and Ballale islands in the neighboring Shortlands. That same month, the 43rd and 37th divisions were involved in the New Georgia campaign. Of the 5 divisions remaining under his control, Admiral Halsey planned to use the fresh and unblooded 3rd Marine division and the Army's 25th division for the invasion. He sought to keep the 2nd marine division and 3rd new zealand division in training for the conquest of Rabaul. Yet things had changed. Because of the intense resistance on New Georgia, the 25th division had to be committed. Then the decision to strike Makin and Tarawa in the Gilbert islands removed the 2nd marine division from Hasley's south pacific area. These changes ultimately dictated he would need a substitution, and it was to be the 37th division, whom had suffered 1100 casualties on New Georgia already. Nevertheless the 37th was in better condition than the 25th. The 3rd marine divisions task went unchanged. Major General Allen Turnage's 3rd Marine division was going to spearhead the invasion of Bougainville, with a launch date set for September. On top of this Halsey had received some reports indicating the Japanese were heavily reinforcing the Shortland Islands. He decided to bypass them and hit the Treasury island and Choiseul. It is also possible Halsey sought to perform these actions hoping to lure out the Japanese fleet into a major engagement. The treasury islands and Choiseul were lightly garrisoned, but held airfields that could be turned against Bougainville. Meanwhile , General MacArthur was planning the next stepping stone towards the Philippines. His overall plan was to break the Bismarcks Barrier through a series of aggressive leaps along the New Guinea-Mindanao axis. New Guinea as we are all quite familiar with by now, is a logistical nightmare. Lush jungles, raging rivers, cold mountains, every time of geographical nightmare was present. Thus to traverse the western landmass of it only on land was not exactly desired. What MacArthur's logistical team sought was to secure the 50 mile expanse of sea lying between New Guinea and New Britain. With that in hand Admiral Barbey's 7th Amphibious force would be able to transport troops along the coast, a significantly easier method than having the poor boys battle through the jungle. Rooke Island split the sea into the Vitiaz Strait and the narrower Dampier Strait. General Wootten's 9th Australian division were currently fighting for control of Vitiaz, but there had been no effort to date to hit the Dampier. MacArthur decided to capture Kavieng and the Admiralty Islands, because they represented enemy aerial threats against his westwards push through New Guinea. Closing in on the end of the year he also planned to amphibious assault Cape Gloucester, the northwestern point of New Britain which commanded the Dampier Strait. In hindsight the wisdom of landing at Cape Gloucester seems rather dubious. It was not necessary to seize the point in order to make use of the Vitiaz or Dampier strait. The Japanese did not have big artillery on the western end of New Britain to command the channel, the islands infrastructure was largely undeveloped. The only way the Japanese could interfere with the allied use of either strait was by torpedo boats, something they did not have many of. There of course was aircraft based on New Britain as well, but that would be neutralised by Kenney's AirSols.  MacArthur planned to have the AirSols hit Rabaul continuously; to seize the Green Islands, the Admiralty Islands and Kavieng. The Western New Britain operation was codenamed Operation Dexterity which would be sub divided into Operations Lazaretto and Backhander. There would be a staggered attack first hitting Gasmata performed by the 2nd battalion, 228th regiment. They would establish an air base in the southern coast of the island, this was operation Lazaretto. Operation Backhander would be the invasion of Cape Gloucester. Some of the landings could be carried out in November, but MacArthur chose to wait until the new airfields were established in the Markham and Ramu valleys as they would provide close air support for the amphibious operations.  On September the 10th, Admiral Hasley sent staff to present his plan for the invasion to Bougainville to MacArthur's staff. Halsey would be surprised to find MacArthur opposed using all their aircraft to strike Rabaul before the invasion of western New Britain. MacArthur proposed instead to continue heavy airstrikes against all Japanese airfields on Bougainville throughout October. Then in late October, Halsey's forces could occupy the Treasury islands and possibly northern Choiseul. Northern Choiseul could provide radar coverage and PT boat bases. On the 1st of November, Halsey's forces could then begin landing on Bougainville to form a beachhead before constructing a new airfield to host the AirSols so they could hit Rabaul just in time to take some pressure off MacArthur's troops advancing in New Guinea and New Britain. Thus MacArthur was determined to make the main goal of the operation not the securance over the entirety of Bougainville, but just a portion of it where an aerodrome could be established then used to batter Rabaul. Halsey was presented two options for his landing site: there was Kieta Harbor sitting on the northeast coast and Empress Augusta Bay on the southwest coast. Kieta seemed the better location from which to launch air strikes against Rabaul. Kieta also held a protected harbor, requiring Halsey's forces to move up the longer outside passage to secure Choiseul first. Empress Augusta Bay was on an exposed side of the island during an approaching monsoon season. It was closer to Rabaul and would only require the securing of the Treasury islands first. After further reconnaissance there was indications airfields could be constructed midway up the west coast of Bougainville at Cape Torokina on Empress Augusta Bay. Halsey chose it for the landing site stating on September 22nd “it's Torokina. Now get on your horses!”  The operation against Cape Torokina was codenamed Cherryblossom and its task was handed to the hero of Guadalcanal, General Vandegrift who formed the plans but it would not be he who lead the operation. Vandegrit was promoted to commandant of the Marines, the first serving marine to become a four star general, he had to depart for Washington. His replacement was Major General Charles Barrett the former commander of the 3rd Marine division. Barret was given command of the 1st Marine Amphibious corps and the responsibility over operation Cherryblossom. His mission statement read “land in the vicinity of Cape Torokina, seize and occupy and defend a beachhead including Torata Island and adjacent island— 3,750 yards west of Cape Torokina—allowing approximately 2,250 yards inland from the beach and 3,600 yards east of Cape Torokina. To prepare and continue the attack in coordination with the 37th Infantry on arrival.” However the mission statement was to be his last major contribution to the war.  On October 8th Barrett accidentally fell from the third floor of the officers quarters at Noumea and suffered a cerebral haemorrhage. He soon died afterwards and was recorded as an accidental death, but there was heavy speculation it was in fact a suicide. Thus the job fell to Major General Roy Geiger, the director of the marine aviation corp in washington. For the naval aspect of the mission Hasley had to do with what he had on hand. He would not be receiving any significant naval reinforcements, because Admiral Nimitz feared that any vessels lent to the 3rd fleet would not be able to come back in time to help with the invasion of the Gilberts. What Halsey could count on was task force 38 commanded by Rear Admiral Frederick Sherman built around carrier Saratoga and later joined by the Princeton; Admiral Merrills task for 39 comprised of cruiser division 12 and destroyer division 23; and Task force 31 commanded by Admiral Wilkinson consisting of three destroyer squadrons, transports and covering ships. It would be Admiral Wilkinson who would bring over the 3rd marine division, the 1st brigade and 3rd New Zealand division to invade the Treasury islands. Rear Admiral George Fort would take the reigns of the first offensive and Wilkinson would looked over the Torokina landings. Wilkinson would have 12 Attack transports and Amphibious cargo ships for the landings, just enough to get every echelon with their equipment over. The 3rd Marine division was reinforced with the 3rd marine defence battalion, the 198th coast artillery, the 2nd provisional marine raider regiment and the 1st marine parachute regiment. After landing at Cape Torokina they would later be reinforced by General Beightlers 37th division. The 29th, 34th and 36th New Zealander battalions of the 8th brigade group led by Brigadier Robert Row would hit the Treasury islands and help establish long range radar stations and a landing craft staging area. There was a final last minute change to the overall plan made by Halsey. They decided not to attempt seizing northern Choiseul but to instead send a marine raiding party around 656-725 men of the US 2nd Parachute battalion led by Lt Colonel Victor Krulak there to persuade the Japanese to divert forces to Choiseul from southern Bougainville.   To support the operation General Kenny's 5th air force would smash the airfields in Rabaul while the AirSols 489 aircraft would hit airfields in and around Bougainville. General Twinning tactics were to harass the Japanese every day, so he launched a total of 158 flights in October, comprising 3259 sorties and land and naval targets in Hahili, Kara, Ballale, Buka, Bonis and Choiseul. The result of this incredible air campaign was 5 Japanese airfields pulverized, 136 enemy aircraft claimed destroyed at the cost of 26 allied aircraft shot down. Meanwhile on October 12th, Kenney launched a raid using 349 aircraft smashing airstrips, shipping and supply dumps. The 6000-ton IJN transport Keisho Maru was sunk alongside two smaller craft. On the 18th 54 B-25's took off from Dobodura, but only caused minor damage. On October the 23rd, 24th and 25th daylight raids consisting of 45 B-242's, 62 B-25's and 61 B-24's respectively managed to shoot down 9 enemy planes, destroyed 25 aircraft on the ground and damaged another 27. On October 29th, he tossed a raid at Vunakanau's airdrome using 41 liberators covered by 75 P-38's and managed to destroy around 10 aircraft. The enemies attention was certainly diverted away from Rabaul. Now the Japanese knew an invasion of Bougainville was coming. They believed the main target of such an offensive would be first against the Shortlands or Kahili. General Kanda's 6th division was deployed to reinforce these places. His 1st battalion, 45th regiment was placed at Kieta, the rd battalion and 4th south sea garrison was sent to reinforce Bougainville while the rest were sent to the Shortland islands. Bougainville was given north/south/east/west sectors garrisoned by numerous forces under Kanda. Admiral Koga also launched Operation RO, a plan devised to strengthen Rabaul. Koga's intelligence indicated the Pacific Fleet was on a warpath, so he decided to take the entire combined fleet from Truk to Eniwetok, which Koga considered a good advance position where he could sortie and annihilate the enemy in a decisive naval battle. The combined fleet stayed a week in the uncomfortable and lonely lagoon until they departed having not found the allied pacific fleet. By October 24th the combined fleet travelled back to Truk while the aircrews of carriers Zuikaku, Shokaku and Zuiho reinforced Rabaul.  82 Zeros, 45 D3As, 40 B5Ns and 6 Yokosuka D4Y reconnaissance planes. 192 trained air crews in total would be in Rabaul by November 1st. They were just in time to intercept one of Kenney's raids consisting of 75 b-25's and 80 p-38s. The Japanese airmen claimed to have downed 9 B-25s, 10 P-38s at the cost of 20 aircraft and 3 small vessels. Koga alerted the 12th air fleet who were in Japan to prepare to head over to Rabaul, but instead of also sending the 8th fleet, he kept them back, still thinking a decisive naval battle would be on the menu soon in the central pacific.  General Sakai's 17th division were transported to New Britain in late september. Their first echelon comprising of the 53rd regiment arrived on october 5th and immediately began to move west to reinforce Cape Gloucester and the 3rd battalion went to northern Bougainville. The remainder of the 17th division would arrive between November 5th and 12th, though the auxiliary cruiser Kurita Maru caring the 1st battalion, 81st regiment was sunk by the USS Grayson. 1087 men, most of the battalion, were lost.  The invasion of the Treasuries codenamed Operation Goodtime. They would establish a staging area, an advanced naval base at Blanche Harbor and a radar station on the north coast of Mono Island. It was hoped the assault on the Treasuries would confused the Japanese as to where the major effort would actually be. At this time there was a short supply of assault forces throughout the Pacific and the Bougainville invasion was mere days away. Thus it was difficult to comprehend why an entire brigade would be used to subdue a tiny enemy garrison on one small island. It has been theorised that Halsey and Vandegrift were reluctant to use some untried New Zealand troops in the more ambitious undertaking, but were also under pressure from their Anzac allies to see some action. For whatever reason the Treasury island operation would be one of the few examples of Allied overkill during the mid Pacific War.  The 8th Brigade had limited shipping available to them. They would have eight destroyer transports, eight LCIs, two LSTs, eight LCMs, three LCTs and two APCs, under the command of Admiral Fort who was using the USS Raton as his flagship. The 34th battalion was going to land on the north side of Stirling Island to secure a nearby airfield; the 29th and 36th battalions would land abreast near Falami Point on southern Mono and Major George Logan D company of the 34th, designated Logan force would land at the mouth of the Soanotalu River to establish a radar station with the help of 20 seabees. The USS Pringle and Philip would perform a bombardment to help. The operation was set into motion on October 27th when the convoy departed guadalcanal and the Russells. George Fort's destroyers approached Blanche Harbor during a storm and began their bombardment. The assault waves raced through the harbor in two columns. As was suspected the 34th met zero resistance, they immediately went to work sending out patrols to make certain if there were any Japanese on the island they would not get to surprise them. Mortars were set up on the nearby Watson island, cool theres an island bearing my name to support the landings on Mono. The landings on Mono met very little resistance, basically just a bunch of surprised Japanese naval troops who offered some half hearted gunfire before withdrawing. The New Zealanders went to work establishing a perimeter as the Japanese began opening fire using mortars which managed to knock out two LST's killing 2 and wounding 30 men. Interesting to note this was the first amphibious assault launched by Kiwi's since the horrible Gallipoli campaign of 1916 and it was the second combat operation undertaken by Kiwi's during the Pacific War. The real resistance would come in the form of a air raid consisting of 25 vals who bombed the beachhead and support ships. The destroyers Cony  took two hits; eight crewmen were killed and ten wounded. An allied fighter patrol managed to shoot down 12 vals during the raid. To their north, the Logan force faced no difficult landing at the mouth of the Soanotalu river. They quickly formed a 150 yard perimeter and began working on the radar station. By the end of the day, all but one LST had successfully unloaded and cleared Blanche harbor, however during the night the New Zealanders tossed back numerous counter attacks, particular around the Saveke river. By the 28th the Japanese survivors were retreating north in the hope of escaping to Bougainville, but along the way they ran into the Logan Force. On October 29th during the late afternoon, 20 Japanese attacked the western part of the Logan Forces perimeter. They were easily beaten off with mortars and rifle fire, leaving 5 dead Japanese behind. The next day saw some intermittent firing against concealed Japanese. Scouts eventually figured out there was a larger number of Japanese to the west of the perimeter, but the area between Soanotalu and Malasi was clear of the enemy.  November began with the rest of the brigade coming over. The radar station was already up and running and the Logan Force had built themselves a small blockhouse near the landing barge. That said blockhouse immediately became the objective of the Japanese, since it represented the only hope of them escaping the island. As Brigadier Row's men began to occupy the central and northern parts of Mono, the Japanese began to infiltrate the Logan Forces perimeter. On the night of November 1st, the main breech was made across the News Zealanders line. A ton of Japanese had infiltrated the lines and managed to cut telephone wires from the blockhouse to the company HQ. Soon after this was accomplished a concerted attack was made against the blockhouse. 6 New Zealanders and 3 Americans defended it. They had automatic weapons, some 50 and 30 cal machine guns, but they were soon put out of action by the attacking Japanese who could have numbered between 70-100 men. The fight for the blockhouse would continue until dawn, with the surviving defenders beating off numerous attacks, mainly by tossing grenades. Captain Kirk, Sergeant DD Hannafin were both killed during the fight. Command of the blockhouse then fell to a cook of D Company, Private J.E Smith. By daybreak the Japanese finally were beaten off as the 3 remaining survivors were all wounded. 26 Japanese had been killed trying to overrun the blockhouse and seize the landing craft. Elsewhere across the perimeter the Japanese attacked throughout the night seeing another 15 dead Japanese in the western section and 9 in the east. It was to be there best chance at taking the blockhouse, for the next few days their attacks were much smaller and by November 4th, New Zealander patrols were fanning out and killing or capturing stragglers. The last significant action on Mono would be on November 6th when a dozen Japanese were routed from a cave during a two hour firefight east of Soanatalu. Operation Goodtime resulted in the annihilation of a Japanese garrison roughly 200 men strong, but it came at a cost. 40 New Zealanders and 12 Americans were killed with 174 wounded. The allies got their supply bases and radar station. Over on Choiseul, Operation Blissful was about to kick off. In an attempt to make the Japanese believe the Shortland islands were the target for their offensive, General Vandegrift tossed Lt Colonel Victor Krulaks 2nd Parachute battalion, roughly 656 men at a beach near the village of Voza. On October 27th the men and their equipment were loaded onto 8 LCMS and during the night the paratroopers were transferred over to four destroyer transports, the Kilty, Ward, Crosby and McKean, the same ships that had just been used to transport the New Zealanders for Operation Goodtime. Forts destroyers provided escort as the Paramarine landed at Voza shortly after midnight without any resistance. During the morning of the 28th they began unloading supplies from landing crafts that had been concealed on a smaller island offshore. Once landed they carried them up a narrow trail leading from the beach a mile northwest of Voza upon some high ground which would be their first base camp. Nearly a hundred friendly natives helped the marines carry the equipment up the beach and they also helped guide the men. Allied radio broadcasting finally alerted the Japanese to the imminent danger to southern Bougainville as Krulaks men began establishing their perimeter. The morning of the 29th brought an enemy strafing attack upon them and the native guides reported to Krulak that there was a barge staging base at Sangigai, the main Japanese position on Choiseul bay, garrisoned by around 150 men. Krulak decided that was to be the first objective, he sent out patrols going north and south. In the north Lt Averill with the help of native guides discover considerable evidence of the Japanese presence, abandoned equipment and rations, but no Japanese. In the south two patrols scouted the Japanese base near Sangigai. Krulak led one of the patrols personally and managed to surprise some Japanese who were unloading a barge. They killed 7 Japanese and sunk the barge before pulling out. The other patrol group ran into a Japanese platoon and got into a skirmish seeing another 7 dead Japanese. Thus Krulak got his confirmation there indeed was a Japanese base at Sangigai.  Early on the 30th, Krulak requested an air strike at it arrived at 6am. 12 Avengers with 26 fighter escorts hit Sangigai. Unfortunately some of the planes mistook the marines at Voza for the enemy and strafed them as well. No marines were killed but one of their boats was sunk, that Krulak had planned to use. As a result of the boat getting sunk, Companies E and 5 departed Voza overland to hit Sangigai. A Japanese outpost along the Vagara river opened fire on the paratroopers, but was easily overwhelmed. Krulak then divided his forces to perform a two pronged assault. Company E led by Captain Robert Manchester would advance along the coastline to hit the Japanese from the north, while Krulak with Company F would move inland to hit them from the rear.  Company E quickly advanced along the coast and began shelling the town with mortars and rockets during the afternoon, only to find out it was abandoned. The Japanese had taken up a new position on some high grounder in the interior. So the paramarines began destroying and looting the village. Meanwhile company F were advancing through rough terrain to try and secure some high ground near Sangigai where the retreating Japanese were just passing through. The Japanese literally walked right into F company and a hour long fight broke out. The Japanese outnumbered F company and as Krulak would later report “the outcome appeared to be in question, until the Japs destroyed their chances by an uncoordinated banzai charge which was badly cut up by our machine guns. Seventy-two Japs were killed and an undetermined number wounded. Marine losses were 6 killed, 1 missing and 12 wounded." The marines had 6 deaths, 12 wounded and one man missing. Krulak was wounded as well as F companies commander Spencer Pratt. The Japanese suffered a devastating 72 casualties Back over at E company after plundering the village they came across some documents  and Krulak reported "The one that fascinated me, it was a chart that portrayed the minefields around southern Bougainville. When I reported this, the night after the Sangigai attack, I saw my first flash message. I had never seen one before. It came back and said, "Transmit at once the coordinates of the limits of the minefields and all channels as shown going through it." So we laboriously encoded the critical locations and sent them off. To an armada going into that area this is not incidental information. This is necessary information. Halsey in true Halsey fashion was not satisfied to know where the minefields were; he, before the Torokina landings, sent in a minelayer there and dropped mines in the entrance ways to those channels and they got two Japanese ships.” E company then retired to the Vagara river and was later evacuated by boat back to the Voza area. F company followed suite but was delayed by the heavy engagement they had. The men stayed to bury their dead. The friendly natives reported a Japanese concentration to the north near the Warrior River, so Krulak sent a strong patrol up by boat to check it out. On November 1, the large patrol of 87 paratroopers from Company G,  led by Major Warner Bigger, headed north by landing craft towards Nukiki with orders "destroy the southern outposts of CHOISEUL BAY, and if possible to shell the Jap supply depot on GUPPY ISLAND." Major Bigger began an overland march along the eastern bank of the river and after crossing the warrior, their native guides became lost so they all had to bivouac for the night. In the early morning of November 2nd, Biggers men found themselves surrounded by Japanese who began infiltrating their perimeter from the rear. Bigger had the men continue north along the beach where the surprise attacked a small enemy outpost of 4 men. They managed to kill 3 of 4, but the last man ran away, thus the element of surprise was gone. Bigger knew the jig was up he could not hope to attack the main objective so instead he ordered the men to go shell Guppy island.  G Company setup some 60mm mortars in the water and fired 143 rounds at the island setting up two large fires, one looked to have hit a fuel dump. The Japanese were taken by surprise there and only offered resistance in the form of some poorly directed machine gun bursts. On the way back G company had to fight their way through because of the infiltrators. Krulak was notified of the situation and alerted a PT boat base at Vella Lavella. Lt Arthur Berndtson had 5 PT boats under his command there, 2 were already assigned to other missions, another was under repair. PT 59 only had ⅓ tanks worth of fuel, but her commander, Lt John F Kennedy, yes he is back in action, agreed to rescue the boys. Kennedy believed he had enough fuel to get to Choiseul and another boat could tow them back to base. Despite overheating the engines, at around 9:30 PT 59 escorted a small convoy to Voza and Bigger's men were off loaded. The PT-59 ran out of fuel on the return trip down the slot and was towed back to Lambu Lambu Cove. By this point the landings at Cape Torokina had been carried out, so a diversion was not really needed anymore. Furthermore the Japanese were moving in on the base camp from all directions. On the night of November 3rd, just in the nick of time, 3 LCIs from Vella Lavella arrived to successfully load Krulaks paratroopers and got them out of there before dawn of the 4th. The Paratroopers had been outnumbered 6-1. They managed to kill an estimated 143 Japanese, destroyed a major staging base at Sangigai, sunk two barges and destroyed a considerable amount of enemy fuel and supplies on Guppy island. The cost was 13 dead and 13 wounded. Krulaks after action report mentioned evidence that the Japanese had sent reinforcements from the Shortland islands to counter the Choiseul operation. On November 1st, the day of the Cape Torokina landings, the Japanese had sent a large bomer force south to Choiseul hunting a reported Task Force. The Japanese found nothing, and by the time they diverted back to Empress Augusta Bay, the landings were done, American fighters were ready to deal with them. It seems the Japanese had been greatly confused from all the activity around Bougainville, particularly from many intercepted messages. Its hard to say how successful the Choiseul raid actually was. It's possible the Japanese fell for the diversion, but no one really knows. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. The diversionary raids may or may not have had an effect on the landings at Cape Torokina. Regardless the multiple operations were all successful and the Japanese seemed none the wiser. Now the stranglehold over Bougainville would begin.

The Clarity Collective Retreat was a resounding success, marked by outstanding achievements in a safe atmosphere. This week, my clients are reflecting on the significant insights gained, the quantum leaps taken, and their plans for moving forward. Buckle up folks; this remarkable group is bursting with excellence.   Discover what my retreat experiences have in store for you. Learn about the profound benefits of coaching within a supportive community, and understand the pivotal role that a secure environment plays in opening up to new opportunities and innovation. I invite you to tune in to the collective wisdom of this entrepreneurial sisterhood.   Get full show notes and more information here: https://www.theuncommonway.com/67   Want clarity? Talk with Jenna about whether the Clarity Accelerator is right for you: https://www.theuncommonway.com/schedule   Website: https://www.theuncommonway.com/ Instagram: https://www.instagram.com/theuncommonway/ Facebook: https://www.facebook.com/theuncommonway/   Amanda's Website: https://amandapopovski.com/ APCS: https://amandapopovskicreative.com/ Amanda's Instagram: https://www.instagram.com/amandapopovski/   Gabi's Website: https://www.gabiandersonstudio.com/ Gabi's Instagram: https://www.instagram.com/gabithecreative/ Gabi's Shop: https://www.gabiandersonstudio.com/shop   Ale's Website: https://www.alegarnica.com/ Ale's Instagram: https://www.instagram.com/iam.alegarnica/   Kat's Linkedin: https://www.linkedin.com/in/katherinehaugh/ Convive Collective: https://www.katherinehaugh.com/

Coronary calcium, cardiac arrest survival, Factor XI drug findings, APCs and a potential new board certification in cardiology are the topics discussed by John Mandrola, MD in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Coronary Artery Calcium -   CONFIRM Registry - https://doi.org/10.1016/j.jcmg.2023.03.008 -   CURE -- https://www.nejm.org/doi/full/10.1056/nejmoa010746 II Cardiac Arrest Cardiac Arrest Centers No Benefit in OHCA Without STEMI https://www.medscape.com/viewarticle/995885 -   Cycling coverage https://velo.outsideonline.com/road/road-racing/nathan-van-hooydonck-forced-to-end-to-racing-career-due-to-heart-condition/ -   ARREST https://doi.org/10.1016/S0140-6736(23)01351-X -   SCD in Athletes Bob Harrington and Manesh Patel https://www.medscape.com/viewarticle/995575 III Factor XI Trial Halted for Bleeding Reduction With Abelacimab vs Rivaroxaban in AF https://www.medscape.com/viewarticle/996587 -   Press Release - https://anthostherapeutics.com/wp-content/uploads/2023/09/2023-09-18-Anthos-Press-Release-final.pdf -   Abelacimab, a Factor XI Inhibitor, Prevents VTE With Low Bleeding Risk in Knee Replacement -   NEJM proof-of-concept https://www.nejm.org/doi/full/10.1056/NEJMoa2105872 -   OCEANIC-AF https://classic.clinicaltrials.gov/ct2/show/NCT05643573 -   Will Factor XI Be the Goldilocks Anticoagulant Target? https://www.medscape.com/viewarticle/979634 IV APC Care NPs and PAs Handling Increasingly More Primary Care Visits: New Studies https://www.medscape.com/viewarticle/996709 BMJ paper -- https://www.bmj.com/content/382/bmj-2022-073933 V Possible Cardiology Board Certification Changes -   Heart Societies Ready to Split From ABIM Over MOC Disputes https://www.medscape.com/viewarticle/996747 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

In This Episode: A boyfriend doesn't know what to do about his girlfriend that wants to become a cop, a family in Ireland has a hard time after their barber refuses to service them, a dweeb tells us about his first "cold approach", a person lets us know they are upset about the Trump indictment, a wife is curious why their security cameras start glitching every time her husband is home alone, and a listener wants to know if they are the asshole for forcing a weekend trip after they got into a fight with their partner. And for this week's Circle Jerdge Erika brings us a new subreddit, I didn't have eggs! This Episode is sponsored by: Daily Harvest! Go to DailyHarvest.com/Judgies and get up to $65 off your first order Get Judgies Merch Here: https://store.streamelements.com/judgiespod Our Patreon is officially open, if you want to see extra content go check it out!  https://www.patreon.com/JudgiesPod  Send us mail! (Addressed However You'd Like)  P.O. Box 58 Ottawa, IL 61350  Leave a Review!  https://podcasts.apple.com/us/podcast/the-judgies/id1519741238  Follow us on Twitter: https://twitter.com/judgiespod Follow us on Instagram: https://instagram.com/judgiespod  Intro Music by: Iván  https://open.spotify.com/artist/5gB2VvyqfnOlNv37PHKRNJ?si=f6TIYrLITkG2NZXGLm_Y-Q&dl_branch=1  Story Links: Time Stamps: 0:00 Intro 1:39 E-Mail Time!!!! 5:43 Mail Time 10:16 r/hasanpiker: My gf wants to become a cop 20:12 r/ireland: Lack of autism awareness is shocking 26:54 r/seduction: Did my first cold approach today 32:57 Return from the Break 33:10 Circle Jerdge: r/IdidntHaveEggs 50:02 Listener Sound Submission 52:47 Listener Story: AITA for making my bf go on a trip with me 57:22 Ricky puts on her tinfoil hat 1:02:01 r/Walkaway: Worst thing about Trump indictments 1:07:53 r/aitah: For asking why cameras don't work when he's home alone 1:09:21 APCs and Spawn Points 1:15:00 Outro Learn more about your ad choices. Visit megaphone.fm/adchoices

In This Episode: We get a NEW STUDIO and talk about our WEEKLY BONUS EPISODES! We also talk about a guy who feels like he "earned" some attention from his gf, a guy who really enjoys the stock market, a boyfriend who went a little too far in his girlfriend's face, a couple breaking up over Avatar the Last Airbender, and a friend group using dumb terms for women. A listener also describes a messy relationship situation and we judge a couple from TikTok.  This Episode is sponsored by: VIIA Hemp! Go to VIIAHemp.com and use promo code JUDGIES to get one FREE Sample on any order! Pretty Litter! Go to PrettyLitter.com/Judgies and use code JUDGIES for 20% off your first order! Hello Fresh! Go to HelloFresh.com/50judgies and use code 50judgies for 50% off plus free shipping! Get Judgies Merch Here: https://store.streamelements.com/judgiespod Our Patreon is officially open, if you want to see extra content go check it out!  https://www.patreon.com/JudgiesPod  Send us mail! (Addressed However You'd Like)  P.O. Box 58 Ottawa, IL 61350  Leave a Review!  https://podcasts.apple.com/us/podcast/the-judgies/id1519741238  Follow us on Twitter: https://twitter.com/judgiespod Follow us on Instagram: https://instagram.com/judgiespod  Intro Music by: Iván  https://open.spotify.com/artist/5gB2VvyqfnOlNv37PHKRNJ?si=f6TIYrLITkG2NZXGLm_Y-Q&dl_branch=1  Story Links: BF EARNED It Stock Market BF's Facial: Deleted ATLA Break Up: APCs and Spawn Points Time Stamps: 0:00 Intro 2:44 Mail Time 6:27 IMPORTANT ANNOUNCEMENT 9:45 Earned It 15:58 Stock Market 25:20 GF's Facial 32:40 CJ: Tiktok Couple 46:54 LS: Love Triangle 1:00:02 ATLA Break Up 1:09:21 APCs and Spawn Points 1:15:00 Outro Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, the penultimate of the first 200, we're excited to have the impending Guiness World Record holder for the largest pencil collection, Aaron Bartholmey. Aaron is also the Secretary-Treasurer of one of our favorite organizations, the American Pencil Collector Society. He talks with us about his collection, counting it for the record, and of course, getting involved with the APCS.Show Notes and LinksErasable PatreonAmerican Pencil Collectors SocietyInterview with Aaron in the Associated PressInterview with Aaron in the Washington PostGuinness World RecordsCurrent Record Holder for Largest Collection of PencilsOur GuestAaron BartholmeyPencilCollector.orgYour HostsJohnny GamberPencil Revolution@pencilutionAndy WelfleWoodclinched@awelfleTim Wasem@TimWasem

Welcome to the Pints and Polishing podcast! In this episode, hosts Marshall and Nick delve into the world of modern interior cleaning and present an innovative solution to address the challenges posed by today's diverse car interiors. Meet Revive, the game-changing interior cleaner developed to cater to the ever-evolving car design landscape. As car enthusiasts with a wealth of experience, Marshall and Nick have witnessed the evolution of automotive interiors over the years. Gone are the days of simple plastic and leather interiors of the past. Today's vehicles boast intricate piano black trim, oversized navigation screens, vinyl, plastic, and luxurious leather – creating a completely different interior cleaning challenge. Enter Revive, the revolutionary modern cleaner designed to handle a wide range of interior surfaces while delivering exceptional results. Unlike traditional all-purpose cleaners (APCs) of the past, Revive is specially formulated to cater to the unique needs of modern car interiors, making it the perfect preparation tool for a maintenance-based cleaning program. What Sets Revive Apart: ✨ Safe on Leather and Sensitive Fabrics: Revive's advanced formula ensures it is safe to use on leather without causing any damage or pulling dye from the surface. It's also gentle yet effective on sensitive materials like Alcantara, making it ideal for high-end, exotic vehicles with delicate interiors. ✨ Tough Cleaning Ability: Revive is a powerful interior cleaner capable of handling heavily soiled areas, such as grimy leather steering wheels or infotainment systems with makeup and lotion residues. Its surfactants do the heavy lifting while maintaining a natural, factory-finish look. ✨ Versatility: Whether you're working on a moderately soiled family SUV or a meticulously maintained luxury car, Revive has got you covered. Its well-balanced formulation makes it suitable for a wide range of interior cleaning tasks, and it excels in maintaining a vehicle's cleanliness on a weekly or bi-weekly basis. ✨ UV Protection: Revive offers additional protection with built-in UV protection, ensuring your car's interior is shielded from the damaging effects of harsh sunlight. Revive is a go-to product for anyone seeking an efficient and safe interior cleaning solution. With its ability to handle diverse surfaces without leaving streaks or heavy scents behind, it caters to both meticulous car owners and professional detailers alike. Who Can Benefit from Revive? Revive's versatility and effectiveness make it a valuable addition to any car owner's cleaning arsenal. Whether you're a realtor, business owner, or even a soccer mom, maintaining a clean and fresh interior is a priority. Revive's easy-to-use formula ensures every inch of your vehicle is kept in pristine condition, providing a natural, factory-like appearance. Join Marshall and Nick in exploring the wonders of Revive and discover how it can transform your car care routine. From easy touch-ups on the go to comprehensive interior maintenance programs, Revive is your ticket to a spotless, well-maintained, and elegant car interior. Tune in to the Pints and Polishing podcast for more exciting discussions on car detailing, product reviews, and tips to keep your ride looking spectacular!

Episode 100 of Another Prank Call Show.In this episode denizens are de-aged, IQ is increased, and DNA is downloaded.Check out the APCS website.Follow APCS on Twitter.Email the show.APCS would not exist without the decades of inspiration from the PLA or the tireless support of Olga.Vista Blue makes cool songs for the show, but you should listen to all their awesome music.World of Prank Calls is a cool website where you can find a wealth of information on lots of other prank call podcasts, and maybe learn a thing or two about making your own.Check out Snow in Southtown, and if you like it, support them on the Snow in Southtown Patreon.Opening song by Vista Blue, background music by Scott Buckley (released under CC-BY 4.0).Special thanks to Chris B for mumbling into a microphone.© 2023 Porcelain Phone Productions

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Has Russia's Invasion of Ukraine Changed Your Mind?, published by JoelMcGuire on May 27, 2023 on The Effective Altruism Forum. [This post was written in a purely personal capacity, etc.] I recently had several long conversations with a friend about whether my regular doom-scrolling regarding the Ukraine war had sharpened my understanding of the world or mostly been a waste of time. Unfortunately, it seems more of the latter. When my mind has changed, it's been slight, and it's unclear what actions my new views justify. Personally, this means I should probably go back to thinking about happiness and RCTs. I set out what I think are some relevant questions Russia's invasion of Ukraine could change your mind about and provide some sloppy commentary, but I'm interested to know what other EAs and rationalists think about this issue. High-level questions Likelihood of great power conflict It seems like the Metaculus forecasting community is now more worried about great power conflict than it was before the war. I assume the invasion of Ukraine is a causal factor. But I feel oddly reassured about this, like the world was ruled by drunks who sobered up when the knives came out, reminded that knives are sharp and bodily fluids are precious. After the invasion, the prospect of a Russia-USA War shifted from a 5-15% to a 25% chance before 2050. I hadn't known about this forecast, but I would have assumed the opposite. Before the war, Russia viewed the US as a waning power, losing in Afghanistan, not-winning in Syria, Libya and Venezuela, riven by internecine strife and paralyzed by self-doubt. Meanwhile, Russia's confidence in its comeback rose with each cost-effective success in Crimea, Syria, and Kazakhstan. Now Russia knows how hollow its military was. And it knows the USA knows. And it knows that NATO hand-me-downs are emptying its once vast stockpiles of tanks and APCs. I assume it won't recover the depth of its armour stocks in the near term (it doesn't have the USSR's state capacity or industrial base). The USA also doesn't need to fight Russia. If Ukraine is doing this well, then Ukraine + Poland + Baltics would probably do just fine. I'd put this more around 6.5%. I think a Russian war with a European state has probably increased simply based on Russia's revealed willingness to go to war, in conjunction with forecasters predicting a good chance (20%-24%) that the US and China will go to war over Taiwan. Russia may find such a conflict an opportunity to attempt to occupy a square mile of uninhabited Lithuanian forest to create a safe zone for ethnic Russian speakers and puncture the myth of NATO's 5th article. Will there be a 'World War Three' before 2050? | Metaculus The predicted probability to this question shifted by around 10%, from the 10-15% range to 20-25% after the war began. I assume this is mostly driven by Russia-NATO-initiated conflict. China-India conflict predictions have decreased from 30% pre-war to 17% before 2035 most recently. And China-US war predictions have stayed constant (20% before 2035). So the rise must stem from the increase in the likelihood of a Russia-US war or by other major powers between 2035 and 2050. I don't think I agree with the community here, as I explained previously. Will China get involved in the Russo-Ukrainian conflict by 2024? China hasn't involved itself in the Ukraine war yet. And the prospects for its involvement seem like they should dim over time — surely it would have acted or given more hints that it was considering doing so by now? This makes me more confused about whether China committed to a military confrontation with the West. If it has, and China believed it had more military-industrial capacity than the West (which is what I'd believe if I was China), then now is the perfect opportunity to drain Western stocks ...

Post-acute care clinicians are facing a wave of challenges that impact how they deliver care. Patients are arriving with increasingly complex needs, while an already overtaxed staff must adapt to regulatory changes and the demands of a new reimbursement model. Meeting these challenges requires a fundamental shift in the model of care delivery in the post-acute setting. SNFs and senior living communities are turning to advanced practice clinicians, who are engaged in hands-on, day-to-day patient care, while also adopting specialty clinical services, like on-call coverage to ensure the staff is supported and equipped to manage patient care throughout all shifts, including the highest-risk shift for readmissions, 11 p.m. to 7 a.m. On this podcast, Jon Raffesberger, DNP, APRN, NP-C, Director of Clinical Specialty Services, Post-Acute Care for TeamHealth, will discuss these challenges, as well as how facilities are overcoming them with new care services, new specialty clinical approaches and an entirely new level of thinking for the growth of post-acute care.

We're talking about WAR here! Trying to leave out politics, though that's really hard with war because it's basically ALL politics but on fire. So we're talking mainly about depictions of it or at least aspects of it, in art and the media. Both Tantz Aerine and myself work on war comics, Without Moonlight and Pinky TA respectively (plus Tantz also does Brave Resistance with Pitface), so we have some knowledge of the subject from a creator perspective. There are a lot of approaches you can take from glorifying war to showing the horrible cost of it, you can show jumbled scenes and impressions or you can show purposeful actions where there's real strategy on show. Tantz depicts a the real historical events of WW2 in Greece using fictional characters (and real historical ones), while I depict totally fictional events with fictional characters. Showing jumbled impressions and cool scenes to give you an idea of a battle being fought, as in a movie like The Return of The King, is a very poor way to do things. In that case it's an epic fantasy, so you're supposed to see the bigger picture; the movement of troops and the purpose of battles, movements and actions etc which you don't in that film. Rather it's just stylised action from a small scale and jumbled impressions from a large scale. In all the original Star Wars films we have great battle depictions because you can see exactly what the purpose of them is as well as looking cool, they don't need meaningless jumbled impressions to fool you into thinking continuity has happened while we transition to the character next scene. Depicting war and battle in a comic is not easy, especially when you're trying to show it from a strategic perspective. You have to think about things very carefully so you can communicate the actions and the purposes behind them. It's far easier to go the jumbled impression route, which is why so many do it, but I would advise against it unless you specifically need to- i.e. the flashback scenes, or the chaotic first hand experience from a person involved in the conflict. Depictions of war and battle don't have to make full logical sense, as long as it FEELS logical for the scene. Like the Battle for Hoth in the Empire Strikes Back - Giant war walker APCs are a silly idea but they seem to make perfect sense in the scene. The dog-fighting scenes with little space-fighters against giant space warships in Return of the Jedi are ridiculous; huge space battleships should have enough weaponry to wipe everything out of the surrounding space for thousands of kilometers in all directions and would never get closer to each other than a blip on radar, and yet when we see that movie the question never coccus to us. Do you depict war and battle, if so how do you do it? What are your tips and tricks? And what are your fave depictions in the media and art? Can be positive or negative. This week Gunwallace has given us a theme inspired by Elmwych - Mysterious, scene setting, classical, plotting, probing and prompting. This is a grand entrance into a cold, lofty manor house where all is not exactly as it seems… simulated strings and electronica spice. Topics and shownotes Future Quackcast: The cussing swearcast. Links Featured comic: Mercury Virus - https://www.theduckwebcomics.com/news/2023/may/09/featured-comic-mercury-virus/ Featured music: Elmwych - https://www.theduckwebcomics.com/Elmwych/ - by Ironscarf, rated M. Special thanks to: Gunwallace - http://www.virtuallycomics.com Ozoneocean - https://www.theduckwebcomics.com/user/ozoneocean Tantz Aerine - https://www.theduckwebcomics.com/user/Tantz_Aerine/ Banes - https://www.theduckwebcomics.com/user/Banes/ VIDEO exclusive! Become a subscriber on the $5 level and up to see our weekly Patreon video and get our advertising perks! - https://www.patreon.com/DrunkDuck Even at $1 you get your name with a link on the front page and a mention in the weekend newsposts! Join us on Discord - https://discordapp.com/invite/7NpJ8GS

With me (your host, Oz Rashid) on this episode, I'm joined by Wade Mitzel – Chief Operating Officer at UofL Health – who shares the reason (I personally believe) why UofL has probably not experienced a shortage of APCs (advanced practice clinicians), even though it's a worldwide issue.UofL Health is a fully integrated regional health system with more than 12,000 employees, made up of highly skilled healthcare professionals. The focus is on the organization's primary mission: to deliver patient-centered care to each and every patient, every day.The discussion centers on living out that mission and culture daily, to make it real and not simply a statement on a piece of paper.In addition, it's about hiring the right people and leading with empathy.I gotta tell you: I have a lot of admiration for this healthcare COO who's second to none in terms of compassion and love for his people.Wade Mitzel - https://www.linkedin.com/in/wademitzelConnect with Oz Rashid on LinkedIn: https://www.linkedin.com/in/ozrashid. Learn more about MSH: https://www.talentmsh.com. Don't forget to rate, download and subscribe to the podcast so you won't miss out on creative, innovative strategies for hiring the best talent.#talent #hiring #learning #teams

*) Zelenskyy expects powerful Western military support President Volodymyr Zelenskyy says that Ukraine is waiting for a "decision from one European capital that will activate the prepared chains of cooperation on tanks." Zelenskyy thanked Estonia for the large package of military assistance and Sweden for its package which included howitzers and ammunition. Zelenskyy also thanked Denmark for the NLAW, Archers and APCs. *) Palestine tells Biden adviser to rein in Israel 'before it's too late' Palestine's President Mahmoud Abbas meets US National Security Adviser Jake Sullivan, appealing to the Biden administration to stop the Israeli government from pressing ahead with escalatory measures against the Palestinians. Abbas urged the United States to intervene before it is too late to stop the unilateral measures by the new Israeli coalition's policies. *) Türkiye expects US to extradite FETO terrorists: Cavusoglu Turkish Foreign Minister Mevlut Cavusoglu says that he hopes Washington will extradite members of the Fetullah Terrorist Organization based in the US. Speaking with members of the Turkish-American community and Ahiska Turks in Houston, Texas, Cavusoglu stressed that FETO members are "intensely" present in the city. Cavusoglu said that FETO's educational institutions were shut down in many countries and their members were handed over to Türkiye. *) At least 145 people feared dead in DRC boat tragedy At least 145 passengers are missing and feared dead after a motorised boat overloaded with goods and animals sank at night on a river in northwestern Democratic Republic of Congo. About 55 people survived the disaster, officials said. The boat was travelling to the neighbouring Republic of Congo when it capsized in the Lulonga River. And finally… *) Kashmir, Chad, Venezuela activists win Martin Ennals Award Campaigners from disputed Kashmir region, Chad and Venezuela win the Martin Ennals Award, one of the world's most prestigious human rights prizes. Khurram Parvez, a prominent rights activist in restive India-administered Kashmir, Delphine Djiraibe, one of Chad's first women lawyers and Feliciano Reyna, a rights activist in Venezuela bagged the award, the jury announced. The award ceremony, managed by Martin Ennals Foundation, will take place in Geneva on February 16, the organisers said.

We are traveling with 5 Recce and they are planning to attack the SWAPO base that was discovered by some systematic sleuthing by Koos Stadler and Jose da Costa as you heard last episode. The base was north of Tethamutete, east of the Cubango River - and from Menongue, heavily armed, a few hundred SWAPO cadres, perhaps as many as 350 were training at what was the Eastern Front HQ. The troops gathered around for the intelligence briefing by Dave Drew before James Hills explained how the attack would unfold. A mortar platoon and two stopper groups, 51 and 53 Commando were ordered to take up their positions north of the base, led by Koos Stadler. They were to approach the base using the same route that the main force would use early the next day. A few kilometres from the target, they left the mortar platoon which setup near the track that ran east to west through the base. Commando 53 then moved directly north of the base, ready to confront any SWAPO attempting to escape north as the stopper group. Stadler headed off west of the target with 51 Commando, also following the track. These two groups formed a significant threat to any SWAPO fleeing in their direction. Just before first light, a company from 101 Battalion, soldiers from 2 Recce reserves, along with the regimental HQ and 51 Commando would assault the base led by Jose da Costa. As this attacking force arrived at the river the mortars would open fire. They took off at dusk, the trucks dropping the troops around 20 km from the target, they covered the remaining ten kilometres on foot and eventually stopped at the east west track. By 0200 they were at the forming up point, the mortar platoon was ready. Starting in January of 1987, the SA Intelligence became aware of a major Soviet airlift of heavy weapons and military supplies from Tashkent north of the Black Sea and from Moscow, all the way to Luanda the Angolan Capital. The Soviets were withdrawing this equipment from Afghanistan where they'd been roundly defeated by the Taliban with American backing. The new equipment arriving in Angola was the latest Russian material, BTR-60 APCs, BRDMS-2 ARVs, BMP-1 IFVs, all were heading south. Heavy transport aircraft were now flying into Menongue daily, carrying food, ammunition, troops. More than 400 trucks were counted traveling back and forth between central Angola and Menongue.

We are traveling with 5 Recce and they are planning to attack the SWAPO base that was discovered by some systematic sleuthing by Koos Stadler and Jose da Costa as you heard last episode. The base was north of Tethamutete, east of the Cubango River - and from Menongue, heavily armed, a few hundred SWAPO cadres, perhaps as many as 350 were training at what was the Eastern Front HQ. The troops gathered around for the intelligence briefing by Dave Drew before James Hills explained how the attack would unfold. A mortar platoon and two stopper groups, 51 and 53 Commando were ordered to take up their positions north of the base, led by Koos Stadler. They were to approach the base using the same route that the main force would use early the next day. A few kilometres from the target, they left the mortar platoon which setup near the track that ran east to west through the base. Commando 53 then moved directly north of the base, ready to confront any SWAPO attempting to escape north as the stopper group. Stadler headed off west of the target with 51 Commando, also following the track. These two groups formed a significant threat to any SWAPO fleeing in their direction. Just before first light, a company from 101 Battalion, soldiers from 2 Recce reserves, along with the regimental HQ and 51 Commando would assault the base led by Jose da Costa. As this attacking force arrived at the river the mortars would open fire. They took off at dusk, the trucks dropping the troops around 20 km from the target, they covered the remaining ten kilometres on foot and eventually stopped at the east west track. By 0200 they were at the forming up point, the mortar platoon was ready. Starting in January of 1987, the SA Intelligence became aware of a major Soviet airlift of heavy weapons and military supplies from Tashkent north of the Black Sea and from Moscow, all the way to Luanda the Angolan Capital. The Soviets were withdrawing this equipment from Afghanistan where they'd been roundly defeated by the Taliban with American backing. The new equipment arriving in Angola was the latest Russian material, BTR-60 APCs, BRDMS-2 ARVs, BMP-1 IFVs, all were heading south. Heavy transport aircraft were now flying into Menongue daily, carrying food, ammunition, troops. More than 400 trucks were counted traveling back and forth between central Angola and Menongue.

Latest news from 04 November 2022, as reported in the Ukrainian media. Support the podcast at: https://www.patreon.com/highlightsfromukraine Just $5 a month grants you access to our special episodes of wartime life stories from Ukraine. Special thanks to our top Patreon supporters - Helena Pszczolko O'Callaghan, Pete Carroll and mattg629! You can tip us via PayPal at: highlightsfromukraine@gmail.com.

Delivery of ASCVD Secondary Prevention Strategies for Rural Communities Guest: Adelaide Arruda-Olson, M.D. Host: Stephen Kopecky, M.D. (@DrSteveKopecky) Dr. Steve Kopecky talks with Dr. Arruda-Olson on the Health of Rural Communities and how to improve our delivery of ASCVD preventive care to rural communities. They will define the rural communities and will talk about how to define secondary prevention. Discussion on why rural communities have more risk factors and how the barriers will be addressed in the Mayo Clinic Health Systems. Joining us today to discuss Delivery of ASCVD Secondary Prevention Strategies for Rural Communities is Adelaide Arruda-Olson, M.D., Associate Professor of Medicine, Department of Cardiovascular Medicine, Rochester, MN Specific topics discussed: What is secondary prevention? How do you define rural communities? Rural communities have an older population, lower income, hospitals are sparse, with less providers & services offered. How can we overcome these issues when trying to achieve secondary prevention? Why do rural communities have more diabetes, obesity, HTN, tobacco, inactivity, obesity among children, drug overdose death? Rural communities tend to be whiter than Urban communities but 54% of native Americans live in rural communities. Are there any special approaches you have for the native American group?  Why do rural communities have worse health outcomes? What are the SOLUTIONS? It appears that it needs to be multifactorial-not only providers, pharmacist APCs, ENTs, but also payment structures for rural care, Telehealth, bricks and mortar for hospitals, and certainly more research ? Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV. NEW Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

Em São Paulo, segundo presidente da APCS, enquanto a arroba suína é negociada a R$ 140,00, o custo de produção para uma arroba do animal é estimado em R$ 153,70

You can get a lot of insight in how coding works and how an Integrated Development Environment (IDE can help the process of compiling, and executing the code you write.

Episode 51 of Another Prank Call Show, produced by Teen Wolf Jesus, my cute friend craig, Phone Losers of America, Mano 1, and CREAM.In this episode hopscotch is hated, raisins are ruined, and antifa finds the ones I love.Check out Snow in Southtown, and if you like it, support them on the Snow in Southtown Patreon.World of Prank Calls is a cool website where you can find a wealth of information on lots of other prank call podcasts, and maybe learn a thing or two about making your own.Support the show on Patreon.Shop the APCS Spreadshirt non-profit store.Check out the APCS website.Leave the show a voicemail at (404) 721-2710Follow APCS on Twitter.Email the show.APCS would not exist without the decades of inspiration from the PLA, and couldn't possibly continue without the support of Olga.Vista Blue makes cool songs for the show, but you should listen to all their awesome music.Opening song by Vista Blue, background music by Ozzed.© 2022 Porcelain Phone Productions

ButtEffer3000 produced this Bonersode, in which a doctor evades surveillance, a resident lives in squalor, and a tough guy spazzes out.Support the show on Patreon.Shop the APCS Spreadshirt non-profit store.Check out the APCS website.Leave the show a voicemail at (404) 721-2710Follow APCS on Twitter.Email the show.Like and subscribe on YouTube.APCS would not exist without the decades of inspiration from the PLA, and couldn't possibly continue without the support of Olga.Background music by Henrik, background intro gibberish by my friend Craig "jarl_marx" Rhonkerson.© 2022 Porcelain Phone Productions

Episode 50 of Another Prank Call Show, produced by lardlord, Karterpiller, Ludwig Van, Luxapol, and Fresh Start Carpet Cleaning and Restoration.In this episode a geriatric graduate is committed, Sandra Bullock inspires bullshit, urban explorers are unwelcome, and I defend my son with a dead zone.Shop the APCS Spreadshirt non-profit store.Check out the APCS website.Leave the show a voicemail at (404) 721-2710Follow APCS on Twitter.Email the show.Like and subscribe on YouTube.APCS would not exist without the decades of inspiration from the PLA, and couldn't possibly continue without the support of Olga.Opening song and background music by seven.© 2022 Porcelain Phone Productions

Dr. Diwakar Davar and Dr. Jason Luke, both of the University of Pittsburgh's Hillman Cancer Center, share the latest news on immunotherapy trials KEYNOTE-A10, LIBRETTO-001, and other key IO studies across tumor types featured at the 2022 ASCO Annual Meeting.  Transcript Dr. Diwakar Davar: Hello, and welcome to the ASCO Daily News Podcast. I am Dr. Diwakar Davar, and I'm an assistant professor of Medical Oncology in phase 1 therapeutics, at the University of Pittsburgh's Hillman Cancer Center, and the guest host of today's podcast. I'm delighted to welcome Dr. Jason Luke to this podcast. He's the director of the Cancer Immunotherapeutic Center at the Hillman Cancer Center, University of Pittsburgh, and a great colleague and friend.  Today we'll be discussing some key posters that highlight some advances in immunotherapy that will be featured and the 2022 ASCO Annual Meeting. You will find our collective disclosures in the show notes and the disclosures of all guests on the podcast are available on our transcripts at asco.org/podcasts.  So, Jason, thank you for coming on the podcast today.  Dr. Jason Luke: Well, thanks very much for the invitation. I always love doing these podcasts for ASCO, and never love anything more than hanging out with my friend Diwakar Davar.  Dr. Diwakar Davar: Well, thank you! Below are the abstracts we've selected. We will start with Abstract 2504. This is a phase 1 trial of the TIM-3 inhibitor cobolimab monotherapy, singly and in combination with the PD-1 inhibitors nivolumab or dostarlimab. Phase 1 data from the AMBER trial with the presenting author being Dr. Gerald Falchook. And this is a trial that initially started several years ago. And I know Jason, that you were involved with the inception of this agent, that TIM-3 inhibitor. So, walk us through, TIM-3. It's a third-generation checkpoint, we now have TIGIT LAG coming into the landscape. Definitely a first indication for LAG-3 melanoma with a positive trial, RELATIVITY 047. So, where are we with TIM-3? Why should we be excited about TIM in general, and this data in particular?  Dr. Jason Luke: It is quite exciting, especially building off the recent data that we saw for relatlimab or LAG-3 because it's becoming clearer that a number of these other immune checkpoints that we have been talking about for many years, actually really can be effective when used in the right setting.  So, this drug, this anti-TIM-3 antibody cobolimab monotherapy, as you mentioned, started out in a phase 1 clinical trial dating all the way back to I think about 2015. And that was at the time in immuno-oncology when everybody was so excited, [and] they thought everything was going to work immediately.  Subsequent to that, obviously, we've had some hurdles that we've had to come over. But we're coming back to some of these agents now, which are looking very exciting. So, just in the same way we think about blocking PD-1 or now blocking LAG-3 to reinvigorate T cells in the tumor microenvironment, there's a good chance and a high probability based on preclinical data that blocking TIM-3 could be just as effective as blocking LAG-3, so to say.  Now, one thing that I note in this abstract is really the safety finding and early PK analysis. And so, this is the important work we do early on to understand the drug. It's important to be aware that in a study like this, it's very hard to seek efficacy signals.  So, when you see this poster, really, you probably shouldn't be thinking, ‘Oh, this is a frontline phase 3 trial,' but rather that the efficacy is going to be a secondary consideration. Rather, what's quite important is looking at the properties of the drug and looking at the safety signals around that. And what we can see here is that TIM-3 appears to be quite safe when blocking it in conjunction with anti-PD-1 across several different tumor types. And that really sets the stage then to think about moving this into earlier lines of therapy across many different cancers.  And so, here we see advanced solid tumors but focused on lung cancer and melanoma and kind of the usual tumors we think about, and people can keep their eyes open because there are other posters of this molecule with PD-1 in some of the other sections outside of developmental therapeutics.  Now, one thing I would like to get your opinion on because your group has focused a lot on TIM-3, as I described it as this T cell centric mechanism to reinvigorate exhausted T cells. But it's possible that TIM-3 does other things as well. And I don't know if you want to comment on that or give any other feedback that you've had when thinking about this AMBER Trial.  Dr. Diwakar Davar: That was an excellent summary, Jason, of really what is a truncated 8-year track record of developing this agent all the way from 2015. But you bring up a very interesting point, which is: exactly what does this drug does in the non-T-cell compartment?  Some very interesting data from Brian Ruffell in a paper that was published about 3 years ago now suggested that TIM-3 was actually potentially a myeloid checkpoint, meaning that, in a tumor model in which Dr. Ruffell was studying this in the context of breast cancer, the drug primarily appeared to work on the effect of antigen-presenting cells and augment the presentation of antigen to T cells suggesting that it may be, in addition to being a chronicle T cell exhaustion marker, it may also be reinvigorating antigen-presenting cells. And the question of whether or not the role of TIM-3 on APCs as well as the role of TIM-3 on T cells, and which of these compartments are more important, and how these compartments segregate in any given cancer across many different lines of therapy will hopefully be something that we disengage, and understand a little bit better as we look at biomarkers of this drug across different settings.  And especially to that point, Jason, the biomarker question, you'll notice that very interestingly, that was a signal in which that drug had a certain response rate. Again, as you correctly point out, we cannot read too much into response rates in very small patient numbers. But very interestingly, there was a slightly higher response rate at the 300 milligrams, which is not the top dose level of the drug, and a slightly lower response rate at the ceiling dose of the drug that was tested, 900 milligrams, leading the investigators to conclude that the RP2D, was actually 300 milligrams every 3 weeks and not 900 milligrams.  What are your thoughts on dose in the context of immunotherapy (IO) drug development? And why might it be that 300 is the optimal dose as opposed to 900?  Dr. Jason Luke: That's a complicated question. I mean, when we think about checkpoint blockade, we classically think about it as only blocking on T cells. But to your point, if there are multiple mechanisms in play, sort of modulating other cell compartments actually may start to do different things at different doses that maybe weren't our primary intent as we went into the trial.  That's a little bit of hand waving, immunologic hand waving, but I think the data are the data and once we hit an effective dose level, there's really no need to really push the dose that much further. But that really emphasizes the importance of these kinds of early phase clinical trials.  So, I'm really looking forward to seeing this data. For disclosure, obviously, we have both been investigators on this trial. But we're very excited about the idea that there may be hope for a fourth checkpoint to come forward in the field beyond just PD-1 CTLA-4, and LAG-3, maybe now here with TIM-3.  Dr. Diwakar Davar: So, with that we'll go to the next abstract and that is Abstract 2516, “Phase I trial of adjuvant autogene cevumeran, an individualized mRNA neoantigen vaccine, for pancreatic ductal adenocarcinoma.”  So, this is an mRNA vaccine from our good friend, BioNTech. And that's been essentially evaluated in the context of highly lethal cancer, pancreatic ductal cancer, and specifically in the context of adjuvant vaccines, specifically in the setting of patients who had followed definitive pancreatic cancer surgery.  So, Jason, you know a lot of neoantigen vaccines, you've led some of these trials, really, the neoantigen vaccine is really the primary reason we are actually having an in-person meeting this year, because if not for this company and others like this, really this pandemic would not be behind us.  What are your thoughts on the role of neoantigen vaccines in cancer therapeutics, and also, particularly this particular trial in the data, the immunological data, and the clinical data regarding the development of neoantigen-specific T cells in this setting, and what this means for you?  Dr. Jason Luke: Right. So, the idea of targeting neoantigens as cancer immunotherapy was really all the rage a few years back, and it was thought based on preclinical animal models that this was just going to be the secret sauce, and this would be the new targeted therapy for immunotherapy. And it isn't to say that that's not true, but the first generation of neoantigen, peptide-based vaccines for the most part, unfortunately, just kind of didn't end up moving the needle the way we had hoped.  The question then was raised: is that because targeting neoantigens isn't reasonable, or is that because the setting where we were trying to do it in the refractory disease area was not the optimal way to leverage this?  And so, a couple of different companies and trials now are coming forward looking at targeting neoantigen in a minimal residual disease setting where the idea could be that immunologic responses that you could generate wouldn't be hampered by all the immunosuppression associated with the tumor microenvironment.  And so, here we have this molecule, which you eloquently pronounced, ‘autogene cevumeran.' It's an RNA-lipoplex neoantigen vaccine. So, it's not a peptide. It's more like the COVID-19 vaccines actually. And it's being given after surgery, followed by anti-PD-L1 followed by chemotherapy.  So, it's a complicated regimen, but it's very intriguing these early data, which do show that the patients who got the vaccine seemed to have better and longer-term outcomes. But then as you emphasize, really, I think probably what's at the heart of this that really makes it exciting is their ability to immune monitor the patients, meaning to look for antigen-specific immune cells from the peripheral blood in these patients to be able to identify those immune responses as being specific to cancer. Because this kind of a clinical trial, it's still signal seeking and proof of concept kind of trial.  In order to actually establish that a vaccine approach in a post-surgical setting would have efficacy, we need to do a large randomized trial. And so, this is not that yet. But I think these data really point in the direction that that could be a reasonable thing to try. And when you think about pancreatic cancer, where we've made no success with immunotherapy, really in a meaningful way in terms of checkpoint blockade, at least, that's pretty exciting actually to think about.  I would actually marry this dataset with another that we actually saw at the American Association for Cancer Research (AACR) meeting that also looked at neoantigen targeting and antigen-specific responses in colorectal cancer, again, and in a similar setting with the minimal residual disease setting.  And so, I think this highlights that we may need to start thinking about using immunotherapy in different ways than we had before. Obviously, everybody knows about using PD-1 blockade in lots of different cancer types that are really for metastatic disease, or maybe even for adjuvant now in melanoma a little bit. But maybe there's this space, which is the minimal residual disease setting where you might be able to detect by ctDNA after surgery, the patients are still positive. And maybe you could treat that before there's visible cancer, and maybe certain immunotherapies could be more valuable in that setting than others. And that's where I think maybe some of these mRNA technologies really might find their sweet spot.  So, coming back to this abstract, I think really, the emphasis point here is the novelty of generating patient-specific neoantigen vaccines, and then being able to track linearly over time the immune response against those vaccines.  I think with that kind of technology and being able to leverage that, I think we're really headed towards a real shift in the way we think about managing cancer in a post-surgical setting, again, thinking about MRD, or minimal residual disease, maybe in a way that our leukemia colleagues have been thinking it about for a long time.  Dr. Diwakar Davar: That's an excellent summary of a very, very complicated, both setting, and in this case, a therapeutic landscape. So, well said, well summarized, and we'll now pivot to Abstract 2514. So, this is ‘Efficacy and safety of NT-I7, long-acting interleukin-7, plus pembrolizumab in patients with advanced solid tumors: Results from the phase 2a study' [and] the presenting author is Dr. Aung Naing from [The University of Texas] MD Anderson [Cancer Center].  So, Jason, you know, with checkpoints, we've got so many thoughts about checkpoints, particularly given the rather unfortunate failure of BEMPEG in the context of melanoma.  So, we've got lots of interesting cytokines that we think of as important in the context of immuno-oncology 2, certainly 12, 15. You've been very involved with IO-15. We've got a lot of clinical trials studying IL-12. And now we've got one studying IL-7. So, tell us what do you think of this IL-7 targeting approach in the context of cytokine-based therapeutics?  Dr. Jason Luke: I think it's really important to emphasize on first principles, for those that are listening, who don't think about immunology all the time that not all cytokines are the same thing.  So, interleukin 2 that many people have heard of is very different actually than interferon. And that's very different from many of the other cytokines, the ILs, and everything, right?  So, IL-7 is a very potent cytokine that's associated with the expansion of immune responses, and that can drive interferon gamma-dependent effects. And you should hear whenever I say interferon-gamma is sort of a link through to PD-1 responsiveness. Because we think the mechanism that underpins anti-PD-1 effectiveness in patients really is interferon gamma biology.  So, IL-7 has been a molecule, it's been of a lot of interest but really was too toxic to try to deliver. But now we have novel drug delivery sorts of approaches that are being developed to try to bring the drug in, in a way that doesn't cause such systemic toxicity.  So, in this clinical trial, this NT-I7 molecule is given intramuscularly, every 6 weeks in conjunction with pembrolizumab, and very interestingly, in a small number of patients, but there were resist responses observed across a series of tumors that you really wouldn't expect should be responsive in any way to pembrolizumab alone. And so, we're talking about microsatellite stable colorectal cancer, pancreatic cancer, and some others as well.  And in conjunction with that, they were able to identify some of the biomarker effects we would think we would see with IL-7, such as expansion of peripheral immune compartments. And the toxicity profile was really consistent with what we've seen with fevers and chills, but manageable in a way that previous approaches really weren't.  So, I think this is really exciting because I think the idea here then is with this IL-7 approach, we might expand the kinds of cancers that we could go after, in conjunction with anti-PD-1 again, pancreas, colorectal cancer. I think that's really where the unmet need lies in oncology.  So, I really applaud these kinds of approaches and several of these cytokine approaches, and what we're going to talk about them, I think, have the potential to do that over the next couple of years.  Dr. Diwakar Davar: Excellent! Pivoting now to a different cytokine, but one that was alluded to before IL-12. So, Abstract 2518 is ‘Phase II evaluation of the combination of PDS0101, M9241, and bintrafusp alfa in patients with HPV 16+ malignancies,' and the presenting author here is Dr. Julius Strauss of the NCI Cancer Center and the Clinical Center of the National Cancer Institute at the National Institutes of Health.  So, what do you think, Jason, about the role of the HPV targeting vaccine, in this case, that was added to IL-12 immune-cytokine and bintrafusp alpha contextualizing the recent data that we have of bintra along with what is a very interesting result here?  Dr. Jason Luke: Yes, I think building on the last abstract where we talked about IL-7 as some novel biology now we move to IL-12, which again introduces other biology. So, interleukin-12 is a complicated cytokine, but one that's strongly associated with initial immune responses or immune priming, as well as enhancement of anti-tumor effects in the tumor microenvironment.  So, here we have sort of a 3-legged approach. So, the vaccination approach against HPV really can generate a strong immune response initially, and that can be supported with the IL-12. And then you come in with anti-PD-L1 and to whatever extent the TGF data is relevant here. And so, you have this cocktail where you're generating tumor-specific responses with a vaccine, you're supporting them with IL-12, and then blocking PD-L1.  And as we go back even a couple of abstracts we talked about, now we sort of have a cocktail right of approaches. And so, I think this is very exciting. It's unique in that, in these tumors, obviously, HPV is the driving force of cancer. So, developing a vaccine against that is fairly straightforward. But I really like this concept of bringing forward sort of a multi-dimensional immunotherapy approach. And we'll note they have previously presented data on this trial, I think last year at ASCO, actually. But what they see are pretty strong response rates, almost 30% range in PD-1 refractory tumors.  Again, that's our area of really high unmet need. It's hard to read through how useful a PD-1 naive treated patient here, although the response rates were high. But to me, it's really those patients who had progressed on PD-1 where they're getting these responses that tells me that this really could be something that's useful and potentially could be expanded beyond just say head neck cancer to any HPV relevant malignancy.  Dr. Diwakar Davar: Excellent! Now on to our last abstract. Abstract 2520, ‘Effect of intratumoral INT230-6 on tumor necrosis and promotion of a systemic immune response: Results from a multicenter phase 1/2 study of solid tumors with and without pembrolizumab (PEM) [Intensity IT-01; Merck KEYNOTE-A10].' The first author is Dr. Jacob Thomas.  Jason, we've seen a lot of interesting intratumoral therapies. You and I have both done a lot of studies in looking at intratumoral agents from toll-like receptor agonists, TLR-9, TLR 7-8, and more recently, oncolytic viruses.  So, contextualizing IT230-6 in the spectrum of intratumoral therapies, how do you feel about this drug, which is actually a very interesting novel drug. It's not just a TLR agonist, or for that matter, an OV, very interestingly, it's an intratumoral therapy that has actually got chemotherapy in it. So, how do you feel about this drug? How do you feel about the responses that we've seen? And particularly how do you feel about the setting in neoadjuvant breast cancer?  Dr. Jason Luke: Yeah. I would pick up where you said that this drug INT230-6 is just a really interesting concoction. So, it's cisplatin mixed with vinblastine, in a specific amphiphilic molecule that allows it to diffuse in through the cancer.  And so, if you had said that to me a few years ago, I would have looked at you and been like, ‘What are you talking about?' But I think the data that's been emerging for this is just really interesting because something about this chemotherapy cocktail actually drives immune responses. And really what the focus of this abstract is on is showing that you get an influx of CD foreign CDTa cells into the tumor microenvironment that's associated with a therapeutic benefit.  I think that's just really, really interesting to think about. It sort of makes one wonder when we're doing these intratumoral injections, how much of it is just the injection, and how much of it is the therapeutic agent, but I think it's a really novel therapy, and one that appears to be very well tolerated as well. And that's also the exciting part. When you hear cisplatin and vinblastine, you think, ‘Oh, well, that's not going to work.'  But apparently, it stays right in the tumor and generates these immune effects. I think it's very exciting. I think their approach here—going after what we usually call cold tumors, ones that don't respond to immunotherapy, you mentioned breast cancer—I think it's really interesting. I'm really looking forward to seeing the actual data from this abstract because, on first pass, it wouldn't have been what I thought about in terms of driving immune responses, but maybe it just goes to show that there's a lot more to understand there about immunogenic cell death and some of these other concepts that we bandy about. But I think this will be one of the most interesting abstracts actually to see the data for once it's available.  Dr. Diwakar Davar: Great! Taking a slight pivot from that. You've been involved in the development of novel response endpoints. One of the issues that we have with intratumoral therapies is that you're measuring a lesion that you inject, so now you inject something and it gets a little bigger. Is it getting bigger because it's growing? Is it getting bigger because the drug is working? We don't know. We have now itRECIST, which you have been working on.  What's very interesting is that whether you look at itRECIST, or RECIST, irRECIST, or imRECIST, when you have the monopoly of different response endpoints we have to deal with these days, these patients have monotherapy responses in non-injected tumors. How do you feel about that as a drug developer and somebody who's giving patients drugs like that? What is your impression of having shrinkage in the non-injected tumor?  Dr. Jason Luke: I think it's really exciting about this concept of the abscopal effect that we've bandied about for years. Despite being an investigator in this space, I'm really excited to actually see the data and to understand what these out of field responses are. If it's really true that this is robust, I mean, it could potentially be like a game-changer kind of thing. But I'll reserve judgment until I see the actual scans of the tumors that actually shrank that weren't injected.  Dr. Diwakar Davar: Fantastic insights, Jason. So, thank you for taking the time to join us on this podcast and to highlight these extraordinarily important advances in immunotherapy.  Dr. Jason Luke: I appreciate the opportunity to participate today.  Dr. Diwakar Davar: So, thank you, and thank you to our listeners for your time today, you will find the links to the abstracts that we discussed today in the transcript of the episode.  Finally, if you're enjoying the content on the ASCO Daily News podcast, please take a moment to rate review and subscribe wherever you get your podcasts.  So, thank you, Jason. And thank you to the team for putting this together.      Disclosures:   Dr. Diwakar Davar:   Honoraria: Merck, Tesaro, Array BioPharma, Immunocore, Instil Bio, Vedanta Biosciences  Consulting or Advisory Role: Instil Bio, Shionogi (Immediate Family Member), Vedanta Biosciences  Research Funding: Merck, Checkmate Pharmaceuticals, CellSight Technologies, Zucero Therapeutics (Inst), GSK, Merck, Arcus Biosciences  Patents, Royalties, Other Intellectual Property: Application No.: 63/124,231, and Enteric Microbiotype Signatures of Immune-related Adverse Events and Response in Relation to Anti-PD-1 Immunotherapy  Dr. Jason Luke:  Stock and Other Ownership Interests: Actym Therapeutics, Mavu Pharmaceutical, Pyxis, Alphamab Oncology, Tempest Therapeutics, Kanaph Therapeutics, Onc.AI, Arch Oncology, Stipe, NeoTX   Consulting or Advisory Role: Bristol-Myers Squibb, Merck, EMD Serono, Novartis, 7 Hills Pharma, Janssen, Reflexion Medical, Tempest Therapeutics, Alphamab Oncology, Spring Bank, Abbvie, Astellas Pharma, Bayer, Incyte, Mersana, Partner Therapeutics, Synlogic, Eisai, Werewolf, Ribon Therapeutics, Checkmate Pharmaceuticals, CStone Pharmaceuticals, Nektar, Regeneron, Rubius, Tesaro, Xilio, Xencor, Alnylam, Crown Bioscience, Flame Biosciences, Genentech, Kadmon, KSQ Therapeutics, Immunocore, Inzen, Pfizer, Silicon Therapeutics, TRex Bio, Bright Peak, Onc.AI, Stipe, Codiak Biosciences, Day One Therapeutics, Endeavor, Gilead Sciences , Hotspot Therapeutics, SERVIER , STINGthera, Synthekine  Research Funding (Inst): Merck, Bristol-Myers Squibb, Incyte, Corvus Pharmaceuticals, Abbvie, Macrogenics, Xencor, Array BioPharma, Agios, Astellas Pharma, EMD Serono, Immatics, Kadmon, Moderna Therapeutics, Nektar, Spring bank, Trishula, KAHR Medical, Fstar, Genmab, Ikena Oncology, Numab, Replimmune, Rubius Therapeutics, Synlogic, Takeda, Tizona Therapeutics, Inc., BioNTech AG, Scholar Rock, Next Cure  Patents, Royalties, Other Intellectual Property: Serial #15/612,657 (Cancer Immunotherapy), and Serial #PCT/US18/36052 (Microbiome Biomarkers for Anti-PD-1/PD-L1 Responsiveness: Diagnostic, Prognostic and Therapeutic Uses Thereof)  Travel, Accommodations, Expenses: Bristol-Myers Squibb, Array BioPharma, EMD Serono, Janssen, Merck, Novartis, Reflexion Medical, Mersana, Pyxis, Xilio  Disclaimer:   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. 

Episode 49 of Another Prank Call Show, produced by Devon Anustart, Phi, Lunchbox420, Heater Peter, and FancyPants.In this episode davenports are distributed, Will Smith gets me in trouble with the law, capitalism is cockblocked by communism, and the sun sets on the British Empire.Support the show on Patreon.Buy the Vista Blue Another Prank Call Show CD!Or buy the digital version, you party pooper.Listen to Snow in Southtown.Shop the APCS spreadshirt store.Check out the APCS website.Leave the show a voicemail at (404) 721-2710Follow APCS on Twitter.Email the show.Like and subscribe on YouTube.APCS would not exist without the decades of inspiration from the PLA, and couldn't possibly continue without the support of Olga.Opening song by Wannaknowmyname, background music by Ozzed.© 2022 Porcelain Phone Productions

radiantradish produced this Bonersode, in which health awareness goes portable, Vista Blue is aglitter, and a prank call premise is not always necessary.Buy the Vista Blue Another Prank Call Show CD!Or buy the digital version, you party pooper.Support the show on Patreon.Shop the APCS Spreadshirt store.Check out the APCS website.Leave the show a voicemail at (404) 721-2710Follow APCS on Twitter.Email the show.Like and subscribe on YouTube.APCS would not exist without the decades of inspiration from the PLA, and couldn't possibly continue without the support of Olga.Opening song by Vista Blue, background music by Henrik, closing song is This One's Not about You by Vista Blue.© 2022 Porcelain Phone Productions

In this episode of The Kickbyke we're chopping it up w/ Levonya Partlow and her company Añuli Pregnancy Care Services.  We dive into what made her start her company, the services that's provided by Añuli and what goes into running it.  We also discuss the challenges she's faced during the pandemic as well as some of her personal experiences thats helps her relate to those who are in need!  We got another good one that you don't wanna miss!  Click  the links  below to check out Levonya and Añuli Pregnancy Care Services.    Don't forget to rate, review and subscribe!  https://anulipcs.org/https://m.facebook.com/Apcs.joy/https://instagram.com/anulipcs?utm_medium=copy_link

Howdy y'all!!  This week on Writin' Nerdy were talking about vehicles in games! Do have a favorite mode of transport?  Do you like to soar through the air in your favorite flight sim or drive like a demon in GTA or Halo?  If so this episode is for you!  Join us as we talk favorite (and least favorite) cars, hoverbikes, APCs, and spaceships - hope you have fun!!!!

Show NotesJuly 9, 2021Many thanks to Rhonda Finnie, DNP, APRN (and a lot of other acronyms due to her many certifications!) for joining me today to examine the role of nurse practitioners and other nonphysician providers in the health care team.We discussed the recent article published in JAMA Neurology by Calli Cook, DNP, and Heidi Schwarz, MD, that called attention to the role of advanced practice clinicians (APCs) in neurology (1). Rhonda's clinical focus for more than 15 years has been neurology and neurosurgery. Currently, she works as a nurse with a 5-member neurosurgical group where she evaluates and cares for patients in the emergency room and intensive care unit. Her clinical activities allow the neurosurgeons to spend more time in the operating room employing their unique skillsAdvanced practice clinicians are a growing part of the healthcare workforce. For example, of the 36,000 members of the American Academy of Neurology, more than 1,600 are APCs. How these providers integrate into patient care with respect to autonomy and scope of practice is very much a work in progress. The inclusion of “midlevels” has not been without its growing pains. Rhonda clarified how the addition of APCs to the healthcare team can benefit patients. Rhonda explained that postgraduate education such as specialty boards can help APCs prepare for roles in neurology. Mastering the neurologic clinical examination is another key to success. Physicians and organizations that employ APCs need to have appropriate expectations. Rhonda emphasized that APCs are “not there to replace the physician.” Physicians shouldn't feel threatened by the integration of APCs into the healthcare team.Please enjoy this 20-minute interview. Your feedback is always welcome.PS: Now available on Alexa! Just ask, "Play podcast The Art of Medicine with Dr. Andrew Wilner!" ReferencesCook CL, Schwarz HB. Advanced Practice Clinicians-Neurology's Underused Resource, JAMA Neurology, May 24, 2021, doi:10.1001/jamaneurol.2021.1416. For more fascinating interviews, please subscribe to “The Art of Medicine with Dr. Andrew Wilner.” www.youtube.com/c/andrewwilnermdauthor www.andrewwilner.com #advancedpracticeclinicians, #midlevels, #AAN, #nursepractitioner, #APCs, #RN, #providers,#locums #locumphysicians 

I discuss recent literature focused on ED operations. Does it pay to advertise?  Do freestanding EDs increase Medicare spending?  We also look at converting Urgent Care centers to freestanding EDs, "surprise" medical bills, the high cost of sending an emergency department bill, and ED utilization of APCs.The focus of the Innovations in Emergency Department Management Course is on leadership, management, operations, logistics, strategic planning and healthcare reform. Hear from “been there, done that” experts who have created successful practices in the ever-changing world of emergency medicine. Although we weren't able to present our live Innovations in ED Management Course in 2020 due to Covid, check out the virtual livestream from December with some of our experts. https://www.youtube.com/watch?v=99e5bJNcDyM