Podcasts about helminth

On episode #67 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/24 – 11/6/24. Host: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia(Nature) Bacterial Implementation of a Pharmacist-Driven Vancomycin Area Under the Concentration-Time Curve Monitoring Program Using Bayesian Modeling in Outpatient Parenteral Antimicrobial Therapy (OFID) Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin (Nature) Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis(CID) Fungal The Last of US Season 2 (YouTube) Notes from the Field: Trichophyton mentagrophytes Genotype VII — New York City, April–July 2024 (CDC MMWR) Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients(Transplant Infectious Disease) Parasitic Outcomes of kidney transplant recipients exposed to Chagas disease under Benznidazole prophylaxis(Transplant Infectious Disease) Fake Aristotle Fakely Rails Against Fighting Inequality (Sententiae Antiquae) Need for a paradigm shift in soil-transmitted helminthiasis control (PLoS Neglected Tropical Diseases) Miscellaneous IDSA Advocacy Results in Big Win for ID in 2025 Final Medicare Rule (IDSA) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice

On episode #63 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/29/24 – 9/13/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Postacute Sequelae of COVID (PASC or Long COVID): An Evidenced-Based Approach (OFID) A New Orthonairovirus Associated with Human Febrile Illness (NEJM) Farmed fur animals harbour viruses with zoonotic spillover potential(Nature) A Cross-Sectional Evaluation of the Virtual Outpatient Management of People With Mpox (OFID) A randomized, placebo-controlled, dose-escalation phase I/II multicenter trial of low-dose cidofovir for BK polyomavirus nephropathy (Transplant Infectious Disease) A Decade of Chronic Norovirus Infection Surveillance at the NIH Clinical Research Center: Clinical Characteristics, Molecular Epidemiology, and Replication (JID) Bacterial FDA clears newLyme disease test (CIDRAP) Lyme ImmunoBlot Receives FDA Clearance(Accesswire) The Utilization Of Echocardiography In Children With Staphylococcus aureus Bacteremia (Journal of Pediatric Infectious Diseases Society) Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better?(BMC Infectious Diseases) Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID) FDA Marketing Authorization Enables Increased Access to First Step of Syphilis Diagnosis FDA) Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia (CID) Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better? (BMC Infectious Diseases) Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID) Fungal The Last of US Season 2 (YouTube) Incidence and risk factors for invasive fungal infections in patients initiating TNF-alpha inhibitors for inflammatory bowel disease and rheumatoid arthritis (CID) Parasitic Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice(Science Translational Medicine) Miscellaneous Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B (OFID) The Impact of Infectious Diseases Scholarly Mentorship on Subsequent Infectious Disease Fellowship Application (CID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

TWiP reviews a study showing that intestinal helminth infection impairs vaccine-induced T cell responses through an IL-10 pathway, which compromised protection against antigenically drifted SARS-CoV-2 variants. Hosts: Vincent Racaniello, Daniel Griffin and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Worms impair COVID vaccines (Sci Trans Med) Heligmosomoides image (Wiki Commons) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Dr. Natalie Scheeler, a naturopathic doctor specializing in integrative treatments for gastrointestinal conditions, shares her perspective and valuable insights on gut health. She discusses the difference between naturopathic doctors and traditional MDs, the use of fecal microbiota transplant (FMT) and Helminthic therapies in treating inflammatory bowel disease (IBD), the impact of food and probiotics on IBD, and trends in flare management and remission. Dr. Scheeler also provides information about her practice, Modrn Med, and offers a final message of hope and encouragement for patients seeking alternative or complementary treatment options. Takeaways Naturopathic doctors focus on preventative medicine and finding the root cause through a whole person approach using integrative treatments that can be used alongside conventional therapies. Fecal microbiota transplant (FMT) and Helminthic therapies are alternative treatments for IBD that show promise in inducing remission and maintaining gut health. Diet plays a significant role in creating a diverse microbiome. Modrn Med is an integrative and functional medicine practice that offers telehealth consultations and works in collaboration with other healthcare providers. There are other treatment options available for patients who have not found success with conventional therapies, and it is important to work with a knowledgeable practitioner to explore these options. Topics covered in the interview Difference Between Naturopathic Doctors (ND) and traditional doctors (MD or DO) Integrative Treatments for Gastrointestinal Conditions Fecal Microbiota Transplant (FMT) Impact of Food and Probiotics on IBD Trends in Flare Management and Remission Helminthic Therapies About Modrn Med From the show Stephanie: What are some of the trends that you've seen with helping people to get out of a flare and into remission? Dr. Scheeler: …the dietary aspect is a large trend I'm seeing I think, too, with social media. There's just the ability to spread so much information and so that is oftentimes how people coming into our office and have said, ‘I've tried these diets' or ‘I've done these diets' versus us kind of introducing them to that idea. So that's interesting. The other one is an herb called Qing Dai. It's a Chinese herb…which is an herb that can be really helpful for inducing remission, typically. We usually reserve it for remission induction versus maintenance therapy because there are some safety risks to that…I would always, always recommend working with a provider who's familiar with that herb…something that is important to say is that natural medicine isn't always safer, and it isn't always safe in general. There is risks associated with any treatments that you do. And so knowing those risks, having somebody who is familiar with those risks is important, especially if you are on the kind of quote-unquote conventional medications and add this stuff in, there could be interactions. Stephanie: Can you talk a little bit about the Modrn Med practice and what types of patients you see? Dr. Scheeler: Yeah, so ModernMed, we are a practice, we are all naturopathic doctors. There's four of us there. And we do integrative and functional medicine. A large part of our practice is gastrointestinal disease, including inflammatory bowel disease. I personally see patients exclusively via telehealth…but there is a location in LA, too, if people are interested. With that, since I do telehealth, I'm licensed in California, Arizona, Maryland, Vermont, and Connecticut, as of now. But all of us depending can either see you as patient if we're licensed in that state or do what we consider educational consults. So with patients who live out of state, we can share some of this information with you and help you do things safely or talk with your provider too…it's very common for us to work with other providers, especially myself working with gastroenterologists. I think when we all work as a team is when we get the best outcomes. And so patients, who may be in a state that we're not licensed in, we're comfortable talking to providers and usually there's no issues with that as long as we explain what we're doing. We always do evidence-based medicine. So as long as we share, even if they're not familiar with it off the bat, most people are open to working together and helping the patient out. Links and studies from the show Modern Med: https://www.modrnmed.com/dr-natalie-scheeler FMT for UC: Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, Andoh A. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin J Gastroenterol. 2018;11(1):1-10. doi:10.1007/s12328-017-0813-5 (PMID: 29285689)  FMT for CD: Zhou S, Cui Y, Zhang Y, Zhao T, Cong J. Fecal microbiota transplantation for induction of remission in Crohn's disease: a systematic review and meta-analysis. Int J Colorectal Dis. 2023;38(1):62. Published 2023 Mar 8. doi:10.1007/s00384-023-04354-4 (PMID: 36882658)  Helminthic Therapy in CD (Trichuris suis specific): Schölmerich J, Fellermann K, Seibold FW, et al. A Randomised, Double-blind, Placebo-controlled Trial of Trichuris suis ova in Active Crohn's Disease. J Crohns Colitis. 2017;11(4):390-399. doi:10.1093/ecco-jcc/jjw184 (PMID: 27707789)  Helminthic Therapy in CD (Trichuris suis specific):  Garg SK, Croft AM, Bager P. Helminth therapy (worms) for induction of remission in inflammatory bowel disease. Cochrane Database Syst Rev. 2014;2014(1):CD009400. Published 2014 Jan 20. doi:10.1002/14651858.CD009400.pub2 (PMID: 24442917)  Paper co-written by Dr. Scheeler on Qing Dai (Pronounced "Ching Dye") a.k.a. Indigo Naturalis: https://www.naturalmedicinejournal.com/journal/clinical-application-of-indigo-naturalis Support the podcast ❤️ at https://www.crohnsfitnessfood.com Get your copy of Crohn's Fitness Food and My Rocky Road to Health, Shop my favorite products, Read my favorite books, Subscribe to the podcast, Send a little love/coffee

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Anti-Helminth Drugs⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbull --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Join us in this episode as Dr Francesca Heard returns to talk us through the clinical presentation, investigations and management of helminth infections. 

There are a shocking number of parasites that can live in the human body and some of them can have surprising effects on the brain, both good and bad! Eddie and Justin break down which parasites can be bad, which ones may be good, which celebrities and historical figures have had parasites, and share a lot of laughs along the way.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5566171/advertisement

Join us in this week's episode, where Dr Francesca Heard explains to us the overview of Helminth Infections. 

Dr. Nirala Jacobi interviews Dr. Mark Davis about helminth therapy and fecal microbiota transplantation (FMT) in the treatment of various conditions. Helminth therapy involves using tiny worm-like organisms called helminths as medicine for humans. Dr. Davis explains that there are four helminths that have been found to be safe and beneficial for humans. These helminths can be used to treat conditions such as multiple sclerosis, ulcerative colitis, Crohn's disease, and autism spectrum disorder. FMT, on the other hand, involves transplanting fecal microbiota from a healthy donor into the gut of a patient. FMT has been found to be effective in treating conditions such as Clostridium difficile (C. diff) colitis and hepatic encephalopathy. Dr. Davis also discusses his new ventures in Panama, where he plans to offer helminth therapy and FMT in a hospital setting. He also mentions his work on vaginal microbiota transplantation for women's health conditions. Dr Mark Davis, ND is a 2011 graduate of NUNM, and a fellow of the American College of Naturopathic Gastroenterology. He's on the board of directors of the Gastroenterology Association of Naturopathic Physicians, and the editorial board of the Natural Medicine Journal. Dr. Davis teaches the naturopathic gastroenterology course at Southwest College of Naturopathic Medicine, and he has focused on patients with IBD since 2016.

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Helminth protects against murine SARS-CoV-2 infection (Sci Immunol) Pandemic spared Africa (ScienceInsider) Letters read on Immune 71 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

On episode #27 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/13 – 4/25/23. Hosts: Daniel Griffin and Sara Dong Click arrow to play Download Puscast 027 (19 MB .mp3, 31 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Prevalence, clinical severity, and seasonality of Adenovirus 40/41, Astrovirus, Sapovirus, and Rotavirus among children with moderate-to severe diarrhea (CID) Antibiotic-prescribing practices for management of childhood diarrhea in 3 sub-Saharan African countries (CID) Drivers of decline in diarrhea mortality (CID) Breastfeeding among people with HIV in North America (CID) Wearable sensor-based detection of Influenza in presymptomatic and asymptomatic individuals (JID) Emergence of erythromycin-resistant invasive group a Streptococcus (EID) Piperacillin-Tazobactam compared With Cefoxitin as antimicrobial prophylaxis for pancreatoduodenectomy (JAMA) VE303 for prevention of recurrent Clostridioides difficile infection (JAMA) Geographic patterns of antimicrobial susceptibilities for Bacteroides species worldwide (IJAA) Intravenous to oral antibiotic switch therapy among patients hospitalized with community-acquired pneumonia (CID) Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalized with suspected gastroenteritis (The Lancet) Treatment of pulmonary mucormycosis with adjunctive nebulized amphotericin B (Mycoses) Giardia detection and codetection with other enteric pathogens in children in the vaccine impact on diarrhea in Africa (CID) Feasibility of training community health workers to use smartphone-attached microscopy for point-of-care visualization of soil-transmitted helminths (AJTMH) Compassionate use of bacteriophages for failed persistent infections (OFID) Music is by Ronald Jenkees

D'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests D'Broski Herbert Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immunology of helminth infections (Ann Rev Immunology) Neuroimmune regulatory networks (J Leuk Biol) Every cell is an immune cell (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

From ASTMH2022 in Seattle, Aisha joins the TWiP team to talk about her training and her career, including delivering a baby on an airplane, and they solve the Case of the Heartsick Guatemalan Septuagenarian. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Aisha Khatib Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Aisha delivers baby on airplane (The Varsity) Helminth infections during pregnancy (J Travel Med) SARS-CoV-2 transmission during air travel (Curr Op Inf Dis) Letters read on TWiP 210 Become a patron of TWiP Case Study for TWiP 210 We are consulted about a rash.  A male in his mid 60s originally from Hong Kong with PMH of T2DM, Hypertension, BPH, Hepatitis B infection, COPD (not on home o2), current smoker, ESRD  with right chest cath on dialysis (MWF) presented to the ED  c/o progressive SOB and DOE for 1 week. 2 weeks prior the patient missed 1 session of hemodialysis. Progressively worsening SOB, DOE, orthopnea began to develop starting one week ago with an associated productive cough with white sputum. Last dialysis was session was 3 days PTA. Pt also began developing nausea and vomiting for 3 days x12 times last week. Pt also started developing diarrhea. Pt has states to have a notable generalized pruritic rash for 3 months that has been worsening. He reports he has been seen by dermatology and was told that the rash is due to certain allergies from food and has been using an unknown cream for 1 month that does not relieve his symptoms. Pt recently admitted for management of bleeding permacath and acute hypoxic respiratory failure likely 2/2 COPD requiring intubation and vent support. Denies recent travel, recent antibiotic use, or sick contacts…but his nephrologist reaches out and is concerned about a certain diagnosis as he says three other patients that come for dialysis have recently been diagnosed with a certain diagnosis. On exam ee has a diffuse symmetrical rash and is scratching the while time. On careful examination there are small linear scabbed areas between his fingers.          9.3   8.97  )———–( 210                28.4  Absolute eosinophil count is >1000 134  |  97  |  51 —————————-

TWiP solves the case of the Long Island Man with Unilateral Eye Pain, followed by a discussion of how enteric helminth coinfection enhances host susceptibility to West Nile virus by a tuft cell-IL-4 receptor signaling axis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Helminth infection enhances West Nile viruses pathogenesis (Cell) Hero: Franz Von Lichtenberg Letters read on TWiP 194 Become a patron of TWiP Case Study for TWiP 194 Woman in 40s, on return from Puerto Rico where she often went. Went to local beaches, brought their dogs. Noticed problem on foot, raised red serpiginous lines, slowly moving all over the foot. Bloodwork showed elevated eosinophils.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

The weeks keep on ticking by... so fast! We couldn't believe it had already been 6 months since the Helminth System had been added to Warframe, so given it was tipped to be such a massive change to the game, we decided we'd have a chat about exactly how much of an impact it has had on the game. Let us know your thoughts as well! (Beginner Topic: weapons used to build other weapons; Advanced Topic: Sniper Combos) https://www.cephalonsquared.com/

Did you know that your hormones and immune system have a complex relationship? This relationship can impact how often we get sick, why women are more prone to autoimmune conditions than men, why more and more people have environmental allergies, and why we develop skin rashes. My guest today, Heather Zwickey, earned a Ph.D. in Immunology and Microbiology from the University of Colorado Health Sciences Center. She went on to complete a postdoctoral fellowship and teach medical school at Yale University. At the National University of Natural Medicine in Portland, OR, Dr. Zwickey launched the Helfgott Research Institute and established the School of Graduate Studies, developing programs in research, nutrition, and global health, among others. Dr. Zwickey applies her immunology expertise to natural medicine research, and she currently leads an NIH funded clinical research training program. She teaches at many universities and speaks at conferences worldwide. Join us as we talk about how the immune system and cytokines can be related to skin conditions. Did you know about the relationship between your immune system and your skin? Let me know in the comments! In this episode: Relationship between hormones (like estrogen and cortisol) + your immune system What are Th1 + Th2? If you've got lots of allergies, there's a big reason why! Helminth worm therapy -- umm, what is that (and how is it related to allergies)? How does cortisol impact the immune system (especially if you've got Topical Steroid Withdrawal) Quotes “There's no one hormone that affects the immune system. They all affect the immune system.” [0:43] “A Th1 response is a set of cells and proteins that are designed to respond to bacteria and virus and a Th2 response is a set of cells and proteins designed to respond to worms and parasites.” [8:10]  Links Find Dr. Zwickey online here GRAB –> Jennifer's Allergen Cross-Reactivity eGuide Healthy Skin Show ep. 072: Sex Hormone-Skin Rash Connection w/ Dr. Carrie Jones Follow Dr. Zwickey on Instagram

There was a secret Devstream this week! Well, OK, it wasn't secret, we just didn't know about it until it happened. It was, as usual, full of good info on both the state of the game, and upcoming changes. Plus, there was a lot of useful info in regards to how people are using the Helminth! We went deep into the data, so check it out if you want to know more about that system. That does, of course, mean that we don't have beginner and advanced topics this week, but we do have all the usual fun, games, and banter. Check it out.

With just over a week and a half left until the release of Heart of Deimos, every Warframe fan worth their salt is thinking hard about what the new Helminth System will mean for the state of Warframe moving int the future. As luck woul;d have it, DE dropped their Developer's Workshop post in regards to this topic, so the Cephalons spend an entire episode going over every single Ability that has been confirmed. Buckle up - it's long and it's bumpy, but it's good! Promise!

Bel spent a few hours playing the Avengers Beta and has some things to say about it.  There are what he feels to be fundamental problems with the game that are not likely fixable before the September 4th launch.  Kodra gives some recommendations for a few Sudoku games that allow you to play some of those interesting edge case games.  We pick up a conversation from last week and talked about Warhammer 40,000 9th Edition and more directly the update cycle for physical games and how it doesn’t exactly work.  Warframe announced a major change at Virtual TennoCon and we talk about the Helminth and how it is going to shake up the meta.  Finally Bel talks quickly about the Tony Hawk Pro Skater Warehouse Demo and how the game feels exceptionally good.   Topics Discussed Avengers Beta is Bad Good Sudoku and Miracle Sudoku Warhammer 40,000 9th Edition The Physical Game Update Cycle Warframe Helminth Gotta Collect Em All Tony Hawk Pro Skater Warehouse Demo is Good

Heart of Deimos represents a new direction for Warframe in a number of ways - from new contraptions that the player can build and utilise, to a whole new system of customisation. We decided to take a look at this through the lens of the future - what do these new additions suggest in the way of change? And what else do we hope comes out of this? Plus all the usual shenanigans. Join us for more fun as we wait on the next update! (Beginner topic: easy frames to farm and feed to Helminth; Advanced: Void Damage overview)

Researcher P'ng Loke investigates how our microbiome and immune system interacts with parasitic worm infections. He relays key points in his research, including The decision one man made 15 years ago to voluntarily infect himself with worms and the results that fascinated Loke, The role the "hygiene hypothesis " plays in the direction of his research, and The findings thus far of helminth impacts on our immune system. P'ng Loke  is a senior investigator at the NIH and Chief of the Type 2 Immunity Section of the NIH's Laboratory of Parasitic Diseases. He explains to listeners that parasitic worms are really good at manipulating their hosts' immune response, particularly in how they affect a type of immune cell called the macrophage. In fact, they are able to remain in hosts for years if not decades undetected. This has huge potential in multiple therapeutic avenues, from organ transplants to overactive immune responses such as inflammatory and other bowel diseases. Loke explains the beginnings of his studies, including a fascinating case of a man suffering from IBD who infected himself with whipworms on purpose after reading some studies and found his disease went in remission. Loke then describes various reasons for this as well as how our efforts toward modern sanitation may have altered our immune system in some ways.   He explains that parasitic worms, like helminths, have figured out how to mask themselves from hosts' immune responses, making them akin to a successful organ transplant. If scientists can understand how they are manipulating the immune response to downregulate or suppress its immunity, they may uncover many therapeutic treatments. He adds that most scientists think it is a spillover response—and the ways they affect the type 2 immune cells such as a type of macrophage cell—can lead to a protective barrier of mucus that prohibits bowel inflammation and disease in some cases. He explains this and other theories in more depth, so listen in. For more, see his lab's website: niaid.nih.gov/research/png-loke-phd Available on Apple Podcasts: apple.co/2Os0myK

In this episode, we speak with Brie Wieselman. Brie is a functional medicine practitioner, digestive health and hormone balance specialist working with women around the world in her online practice. Join us for a fascinating discussion with Brie about starting to restore balance to an imbalanced gut using fermented foods, probiotics, and Helminth (worm) therapy. Tune in to learn more!

Would you give yourself an intestinal worm if it meant you'd no longer have allergies or symptoms of an autoimmune disease? Would you give a few to yourself if it meant preventing those conditions altogether?  Duke researcher, Dr. William Parker, talks to Andrea about the groundbreaking field of helminth therapy. On this episode, Andrea talks to Dr. Parker about the “ick” factor of giving yourself worms, the different types of worms used in therapy, and dosing.   Because this is NOT an FDA-approved therapy, they also discuss the obstacles to treatment and what we know about how helminths interact with the rest of the microbiome. This episode is powered by BIOHM Health, a leader in gut health and the only probiotic engineered to focus on the fungi in the gut in addition to bacteria. 

Intestinal worms, like some types of bacteria, have gotten a bad rap in our hyper-sanitized modern life. But over the last fifty years, scientists have begun to question whether or not the vast eradication of these ancient friends has caused more long-term harm than good. In today’s episode, we talk about the hygiene hypothesis and how some people today are trying to right the wrongs of their immune system by reintroducing certain worms into their bodies. Spoiler alert: I’m one of them! This practice is called helminth therapy, and no, it’s not at all sanctioned by the FDA. However, many desperate chronically ill patients have resorted to trying it and the stories include some incredible transformations. One person who is at the forefront of helminth research and analyzing these self-administered helminth case studies is Dr. William Parker, who just so happens to be our guest for this conversation. Dr. Parker has studied biochemistry and immunology at Duke University since 1993. He is best known for the discovery of the function of the human appendix as a safe-house for bacteria. And his work on “biota alteration,” has led to many of the discoveries about intestinal worms’ role in human health. Dr. Parker has published more than 120 peer reviewed papers, including a number of widely acclaimed studies comparing the immune function of wild rats with that of their cleaner and more “Westernized” cousin, the laboratory rat. If you have an autoimmune condition or are just curious about how worms can support (rather than hurt) our gut health, today’s episode is for you. Next week we are off for the holiday - stay well, and I will see you in 2020!! A quick taste of what we’ll cover: What conditions have seen positive outcomes with helminth therapy, and which should be avoided The different types of worms used and potential symptoms Risk factors and ways to mitigate them The best ways to apply hookworms My personal experience with using helminth therapy to lower my Hashimoto’s anti-bodies And so much more... Resources, mentions and notes: Dr. Parker’s website and facebook page Moises Valasquez-Manoff’s book an Epidemic of Absence The Hygiene Hypothesis Why We Need Worms  Helminth and Joint Inflammation  Whipworm and IBD Helminth Therapy WIKI Phoebe’s book, The Wellness Project, on her journey with Hashimoto's Join the SIBO Made Simple Facebook Community Page Subscribe to receive a free low FODMAP cookbook   This episode is brought to you by 4 Weeks to Wellness, my online program for finding the sweet spot between health and hedonism. Need 4-weeks worth of easy low FODMAP recipes with a step-by-step meal plan laid out for you? You’ll receive a 20-recipe cookbook, complete with shopping lists, elimination diet guidance and reintroduction worksheets, in addition to the many other program resources like my symptom and activity tracker, lymphatic massage videos, doable desk stretches, and so much more. The 300+ people who have joined the tribe have reported clearer skin, calmer tummies, less bloat, tamer food cravings, and a general ease over their newfound habits. To find out more details about when the next session starts, click here. Use the code SIBOMADESIMPLE at checkout for $40 off!   Disclaimer: The information in this podcast does not provide medical advice, professional diagnosis, opinion, or treatment. The information discussed is for educational purposes only and is not a substitute for medical or professional care.

On this episode, we'd like to introduce you to hookworm! He's the man with a plan, but will it be enough to sway your heart?Theme music is "Lovesick" written and performed by Mors Ontologica.

On this episode, we'd like to introduce you to hookworm! He's the man with a plan, but will it be enough to sway your heart?Theme music is "Lovesick" written and performed by Mors Ontologica.

Many SIBO treatments do a great job of killing your unwanted bacteria, but they don't necessarily set you up for long-term good gut health. In today's episode, we are going to go a little bit deeper into some of the herbs and natural supplements that can be used as part of your SIBO toolkit. My guest, Dr. Will Cole, is a leading functional-medicine expert and author of the new bestselling book, Ketotarian, in which he melds the powerful benefits of a ketogenic diet with a plant-based one. More importantly, he treats acute digestive issues like SIBO with the whole microbiome in mind. In today’s conversation, we dive deeper into his approach and cover so much ground, including: What effect non-steroidal anti-inflammatory drugs (NSAID’s – like advil) can have on the microbiome the role of epigenetics in SIBO, meaning how our lifestyle choices can switch genes on and off how your microbiome is more than just your SIBO, and ways to support it overall histamine intolerance and how that effects your natural treatment plan Whether you should take probiotics while using herbs to kill your SIBO Biofilm and how to fight it Die-off symptoms (also known as Herxheimer response) and how to know if this is what you’re experiencing versus an intolerance of something in your treatment What supplements to take to prevent relapse How to use your diet as a way to prevent relapse Gut-brain connection: Stress management and how that influences SIBO And some other lesser known options like Helminth therapy For more info on each episode, plus gluten-free (low FODMAP) recipes, healthy living tips, and more, visit https://www.feedmephoebe.com. Follow at @phoebelapine on Instagram for more daily insights and lessons. 

The Podfessors solve the case of the Itchy Child from Panama, and discuss competition for blood in human malaria-helminth co-infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Competingfor Blood (Ecol Letters) Parasite Hero: William C. Campbell Image credit Letters read on TWiP 151 Case Study for TWiP 151 Woman in 30s, mother of last two boys we saw, same locale. Concerned about abdominal pain for 3 years. Fullness, bloating of lower abdomen. No blood in stool, but occasionally loose stools, difficult to clean, stick/pasty/greasy stool. Had visited hospital, underwent test, told it is an ovarian cyst and needs surgery. Took omeprazole, allbendazole, azithromycin, none helped. On exam, diffuse abdominal tenderness. Portable ultrasound: small ovarian cyst 1.5 cm, not tender. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Helminth therapy essentially refers to using health-promoting worms in a very similar manner to how we use probiotics. Healthy helminths may be an important, and missing, part of our gut microbiota communities. By restoring these to our intestinal tract it may be possible to reduce inflammation, balance the immune system and improve autoimmunity. Today we speak with Dr. Nancy O'Hara who has been using helminths in her clinical practice for years. My new book is finally available: Healthy Gut, Healthy You. Click here to learn more: https://drruscio.com/getgutbook/ Looking for more? Check out our resource page that includes how to become a patient, how to pick up a copy of my new book, how to sign up for my clinical training newsletter, and more. https://drruscio.com/resources

Today we follow up on our recent conversation on helminth therapy, aka intestinal worms.  We speak with Garin Aglietti, who is a worm farmer and works first-hand in helping people rebalance their gut ecology with worms.  As weird as it sounds, intestinal worms used to be the norm and the current day absence of them may open the door for inflammatory and autoimmune conditions. My new book is finally available: Healthy Gut, Healthy You. Click here to learn more: https://drruscio.com/getgutbook/ Looking for more? Check out our resource page that includes how to become a patient, how to pick up a copy of my new book, how to sign up for my clinical training newsletter, and more. https://drruscio.com/resources

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPerati solve the case of the Man Who Sat in Feces, and discuss a study on how Dickson's favorite parasite induces the formation of a collagen capsule. Become a patron of TWiP. Links for this episode: Induction of collagen synthesis by Trichinella (Vet Parasitol) Letters read on TWiP 128 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twip. Case Study for TWiP 128 Daniel doesn’t expect anyone to get this. From Australia, 80 yo retired teacher from Atherton, northheast Australia, presents to clinic with generalized weakness, concern of chronic lyme or Q fever. Seen by neurologist, concern about motor neuron disease. 18 months of illness, insidious onset of limb (arms and legs) weakness. No issues with speaking, swallowing or breathing; no weight loss; no fever, sweat, chill. History of osteoarthritis, joint replacements; myocarditis; vertigo; allergic to pen and dox. Father, rhematoid arthritis, brother colon cancer. On a number of medications. Does extensive travel, when not traveling, is a volunteer carer in Australia (abandoned wildlife), over the past three years. Lives with husband. Marsupials, hand feeds puggles and juvenile spiny anteaters, has pet cockatoo. No history of polio, HIV negative. Neuro exam: diffuse non tender muscle with no rash. Normal upper and lower limb tone, strength is symmetrically reduced proximally. Reflexes good at knees, normal sensation to all modalities. Normal cranial nerve exam. Test results: has eosinophilia, elevated muscle enzymes, EMG shows myopathic changes, nerve conduction normal. Stop statin therapy, no change. This is a rare parasite. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Helminth hacking, the rise of fake news, and uncovering the mystery behind ASMR.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPniks docs solve the case of the Female from Peru with Epistaxis, and discuss the effect of community deworming on immunosuppression. Become a patron of TWiP. Links for this episode: Community deworming and immune hyporesponsiveness (PNAS) Paul C. Beaver (one, two) Photo by Oscar Adam Oscarson Letters read on TWiP 122 This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This show is sponsored by Drobo, a family of safe, expandable , yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20. Case Study for TWiP 122 First of a series of cases with a theme, a 23 yo female international aid worker, chief complaint of diarrhea. Dutch descent, born in US, been in rural area of western DR, close to Haitian border. It’s been raining, houses have tin roofs, other flat concrete, rainwater pours off. Child comes by with mangoes, she buys one, washes it in rain water from the roof. Bites open mango, peels it, eats mango. The same night she is not feeling well, loose stools, abdominal discomfort. Next day, goes with group to border town; then has full fledged diarrhea. Looks into toilet, sees white objects 1 cm in length on stool, and they are moving. Uniform width, thinner than long, wormy looking. Has been participating in other activities in this area, swims in local river, walks barefoot, eating lot of local foods. Lunch: rice, beans, cooked meat, avocado. Dinner, yucca, fried salami, etc. Healthy before, no family history, not on meds, living with one of local families, no toxic habits. Dogs, cats, pigs, chickens around. One month earlier, cat in family home had kittens, she played with them. Very excited about that. Local physician contacted, he treats her.  Send your case diagnosis, questions and comments to twip@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.   Subscribe to TWiP (free) in iTunes, by the RSS feed or by email Links for this episode: Helminth infection promotes colonization resistance (Science) NOD2 (Wikipedia) Image credit Letters read on TWiP 112 This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Become a patron of TWiP. Case Study for TWiP 112 A case here at CUMC, 59 yo male, past medical history of childhood polio, presents with worsening lower extremity weakness, bowel and urinary incontinence. 2 year before worsening back pain, weakness, could not work. Cannot walk up one flight of stairs since 1 month; 1 week prior to admission had fever, no headaches, diarrhea, cough, or any other symptoms. Splits time between Washington Heights and Mexico. Construction worker. Rural town in southern Mexico, 10 months of the year. Worked in the corn growing area. Has been exposed to bugs. Stopped working in cornfields 20 years ago. Has son and daughter, visits them. Lives with wife, stays in Mexico, she is fine. HIV negative. Eats home prepared foods, no dietary restrictions. Physical exam: not febrile, vital signs all good, neurological: upper strength good, weakness in hip flexors, ⅗; quadriceps, but ⅕ in lower extremities ⅖ in right. Sensory has decreased as well. Possibly spinal lesion. Labs: elevated glucose, ESR 33, CRP 2.2, whites 8, 30.6 hematocrit, guaiac negative. Imaging: MRI of spine shows normal vertebrae, T9/10 inflammation of spinal cord, mass lesion, compromise of canal. Brain MRI: hydrocephalus. Problem with recirculation of CSF.  Send your case diagnosis, questions and comments to twip@microbe.tv

In this edition of the Equine Veterinary Education (EVE) podcast, Undine Christmann and Courtney Pink discuss their experience of dealing with an outbreak of strangles and Craig Reinemeyer speaks about the control of helminth parasites in juvenile horses To access the papers discussed in this podcast, please follow the links below:   1. http://onlinelibrary.wiley.com/doi/10.1111/eve.12451/abstract   2. http://onlinelibrary.wiley.com/doi/10.1111/eve.12541/abstract  

Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Babesiosis (CDC) Babesiosis blood smear with Maltese cross (NEJM) Helminth proteins prevent diabetes in mice (PLoS One) Letters read on TWiP 82 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Consequences of living in a wormy world (Am Nat) Opposite effects of antihelminthic treatment on microbial infection (Science) Send your case study solutions to twip@twiv.tv Daniel's cufflinks (jpg) Daniel's TB bowtie (jpg) Image credit Letters read on TWiP 81 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Vincent and Dickson discuss how infection of mice with helminths induces cytokines that reactivate a latent gamma-herpesvirus. Hosts: Vincent Racaniello and Dickson Despommier Links for this episode: Helminths reactivate herpesvirus (Science) How helminths go viral (Science) Herpesvirus latency protects from bacterial infection (Nature) Image credit Letters read on TWiP 76 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive. Hosts: Vincent Racaniello and Dickson Despommier Links for this episode: Wormholes in host defense (PLoS Path) Lung coin lesion (Wikipedia) Granuloma (Wikipedia) Jar that Dickson is holding (jpg) Letters read on TWiP 72 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

A case-based review of common helminthic parasites.

A case-based review of common helminthic parasites.