Podcasts about Rotavirus

Babies receive a shocking number of vaccines in the first year of life. This episode covers the Hepatitis B, Rotavirus, and Polio vaccines.This is installment 3 of our intermittent series on vaccines. You can find the first here: https://rumble.com/v6lk9ka-the-vaccine-conversation-s5-ep17.html?e9s=src_v1_ucp The second here: https://rumble.com/v6qw46q-adolescent-vaccines-hpv-and-meningococcal-s6-ep2.html?e9s=src_v1_ucp And here, you can find a list of vaccine research resources Abby has compiled and continues to update as she continues her research: https://docs.google.com/document/d/1ctSD3J4I-aVNO3JSeopqIXRZkXDdUq4NhqgubGxHN4s/edit?usp=sharing ---------- Support the show and get bonus UNHINGED episodes ---------- LOCALS - https://conspiracypilled.locals.com/ MERCH - https://conspiracypilled.com/collections/all Join the DISCORD - https://discord.gg/c8Acuz7vC9 Give this podcast a 5 Star Review - https://ratethispodcast.com/conspiracypilled ---------- SPONSOR ---------- NORTH ARROW COFFEE - https://northarrowcoffee.co Use code CONSPIRACY10 to get 10% off your order! ------- FOLLOW THE HOSTS ------- Abby — @abbythelibb_ on X and InstagramLiz —- @adelethelaptop on XJon —- @Kn0tfersail on XMusic by : Tyler Daniels Become a supporter of this podcast: https://www.spreaker.com/podcast/conspiracy-pilled--6248227/support.

TWiV covers a second death over 150 cases of measles in Texas, utter failure of removal of type 2 poliovirus from OPV, more OPV doses administered in Gaza, second Ebola outbreak in Sudan, vaccine being tested, Trump administration cancels $400 million in grants to Columbia University, bat-infecting merbecovirus that binds human ACE2 and infects human cells, and innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Second child dies of measles (NY Times) Over 150 measles cases in Texas (Texas DSHS) Utter failure of removal of OPV2 from OPV (Science) Over 600,000 doses of OPV administered in Gaza (polioeradication) Second outbreak of Sudan Ebola in Uganda (IAVI) Columbia grants canceled by administration (NBC News) Bat merbecovirus also infects human cells via Ace2 (Cell) Recent virus research, was proper containment used? (NY Times) Innate immune sensing of rotatvirus leads to diarrhea (Cell Host Microbe) Timestamps by Jolene Ramsey. Thanks! Weekly Picks Kathy – Mice cry out when they urinate, and give mouth to mouth resuscitation Rich – Firefly Aerospace Alan – Strong Museum of Play Vincent – How a PhD student's lab size affects their chance of future academic success Listener Picks Larry – James Harrison's rare blood protected many infants Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Rotavirus viroporin activity, calcium waves, and pathogenesis (Sci Adv) T cells control human orthoflavivirus challenge (Nat Micro) Letters read on TWiV 1189 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – The Perfect Cacio e Pepe Recipe, According to Science (primary article here) Kathy – Dragonflies Loop-the-Loop Alan – My Beloved Monster, by Caleb Carr Vincent –  Why Did the FDA Ban Red Dye #3 Listener Picks Anne – Japan's 65-Foot Towering Snow Walls Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

El Departamento de Salud del Gobierno de Navarra actualiza su estrategia de vacunación y, como principal novedad, incorpora al calendario de vacunaciones a lo largo de toda la vida de 2025 la inmunización frente al rotavirus para los bebés que nazcan a partir del próximo 1 de enero

El resumen de la actualidad navarra del jueves 2 de enero

"Das Klima”, der Podcast zur Wissenschaft hinter der Krise. Wir lasen den [sechsten Bericht](https://www.ipcc.ch) des Weltklimarats und erklären den aktuellen Stand der Klimaforschung. In Folge 127 ist fast Weihnachten, aber wir beschäftigen uns mit Corona. Das gibt's nämlich nicht nur noch, die Klimakrise sorgt auch dafür, dass wir uns leichter damit anstecken. Denn je mehr CO2 in der Luft ist, desto stabiler sind die Viren. In stickigen Räumen kann man lüften. Aber wenn die Klimakrise so weiter geht, dann ist bald die gesamte Erde ein ungelüfteter Raum, mit all den Nachteilen in Sachen Infektionskrankheiten, die das mit sich bringt. Frohe Weihnachten! Wer den Podcast unterstützen will, kann das gerne tun: https://steadyhq.com/de/dasklima/ und https://www.paypal.me/florianfreistetter.

We share how you can prevent scours this calving season, but you have to act now!  We have the latest news, market recaps, horse for sale, ranch channel listings and lots more on this all new episode of the Ranch It Up Radio Show.  Be sure to subscribe on your favorite podcasting app or on the Ranch It Up Radio Show YouTube Channel. EPISODE 216 DETAILS Prevent Scours This Upcoming Calving Season Plus Cattle Industry News How To Prevent Calf Scours: Feed Farmatan Feed Farmatan To Prevent Scours This Calving Season Calving season is getting ready to start for many producers and for some others it is still a ways away yet.  Regardless, we need to get a jump on scours and make sure each and every calf that hits the ground has the best chance of survival.  A simple solution… FARMATAN from Imogene Ingredients.   WHAT CAUSES SCOURS IN BEEF CATTLE/CALVES Clostridia-Enterotoxemia The most common form of Clostridium in cattle is caused by Clostridia perfringens. The gram-positive bacteria are a challenge due to its ability to form spores and lay dormant for long-periods of time. The bacteria reproduce by releasing spores into its environment (soil, feed, manure). The spores can even lay dormant in the animal's intestine until opportunity presents itself. Infection takes place either through ingestion of spores or through an open wound. The most severe cases happen within the first month of a calf's life, and can result in sudden death. Clinical Signs Diarrhea - Bloody, Mucus Present, Bubbly Dehydrated Bloat Blindness Prevention/Treatment: Prevention can be difficult due to the Clostridia spores being extremely durable and present almost everywhere. Complete cleanout and disinfection between calves is helpful, but not always effective. A good vaccination program will reduce clinical disease. The best method is to develop good gut health and the immune system of the calf. Farmatan has been shown to strengthen the intestinal wall, helping to prevent infection from taking hold. Coccidiosis Cattle are host to numerous species of Coccidia, a single-celled protozoal parasite. Infection and clinical symptoms can happen any time during a calf's life, with the most severe reaction usually occurring between 3-6 weeks of age. The life-cycle of coccidia requires time to infect the intestine causing destruction of the mucosal and epithelial lining. The oocytes mature outside the host in warm, moist environments before being consumed, causing infection of a new host. Clinical Signs Diarrhea - Watery, Bloody Depression Weight Loss Prevention/Treatment: Prevention of Coccidiosis is possible by keeping young calves separate from older animals, providing clean water and feed, and dry conditions. Isolation of infected animals is key to preventing transmission. Keeping the pen dry is the most important step a farmer/rancher can take in preventing Coccidiosis. Treatment can have a good impact on reducing secondary disease, and speeding up recovery time. Farmatan has been shown to disrupt the reproductive cycle of Coccidia; and may help strengthen the intestinal wall to prevent infection, in both the cow and calf. Coronavirus Bovine Coronavirus is a ubiquitous, envelope-viral disease, causing respiratory and enteric infection. There are many serotypes for this virus, making it difficult to test for, and create a vaccine. Coronavirus can present as either diarrhea and/or respiratory illness; transmitted through nasal discharge and/or feces. Animal reservoirs continue to spread the disease, and make eradication almost impossible. Clinical disease will likely occur between days 10-14, and present for up to 4 days. Clinical Signs Diarrhea - Watery Nasal Discharge Coughing Prevention/Treatment: Prevention is difficult due to wild animals transmitting the disease. Keeping wild animals out of animal enclosures is essential. Isolation of infected animals is critical to preventing the spread of Coronavirus. Adequate colostrum intake, along with a good vaccination program will help prevent clinical disease. Learn more about the positive effects of Farmtan's active ingredient on Coronavirus HERE. Cryptosporidium Cryptosporidium Parvum is a single-celled parasite responsible for causing infection in young calves. The infection takes place within the first four weeks of a calves' life, afterwards immunity has developed within the calf. The parasite is either passed from the cow or spread through infected water sources. Clinical Signs Diarrhea - Watery, Bloody, Mucus present Colic Depression Prevention/Treatment: Good sanitary conditions, especially clean water is essential in preventing transmission of cryptosporidium. Isolation of sick calves will help reduce the effect on the overall herd. There is some good effect of calves given adequate colostrum, however this is likely helping by reducing other pathogenic loads rather than a direct effect on Cryptosporidium, itself. Farmatan fed prior to calving has been shown to disrupt the life-cycle and reduce transmission from the cow. The direct action of Farmatan on the parasite makes it an excellent choice for treating calves. Learn more about the positive effect of Farmatan's active ingredient HERE.   E Coli Escherichia Coli is a bacterial infection that affects calves within the first week of their life. The bacteria colonize in the lower intestine and produce a toxin. The toxin causes excessive secretion of fluids. The zoonotic disease has special importance in food safety and human health. Colostrum and natural immunity are often not sufficient in preventing infection in cases of high bacterial concentrations. Clinical Signs Diarrhea - Creamy, Yellow Abdominal Pains Fever Vomiting Prevention/Treatment: The best prevention methods for E. Coli include: clean water, dry bedding/environment, isolation of infected animals, and vaccination. Treatment with antibiotics and oral fluids have great benefits in reducing clinical symptoms of the disease. Farmatan has been shown to reduce bacterial load and help prevent infection. Learn more about the positive effects of Farmatan's active ingredient HERE. Rotavirus Rotavirus in calves is caused by a virus belonging to the Reoviridae family, as a non-envelope RNA virus. Rotavirus is thought to be the most common cause of neonatal diarrhea in calves. The virus tends to affect calves between the age of 1-day-old up to a month, with most cases presenting within the first week of life. Shedding and reinfection can happen in older calves and cows. Clinical symptoms are rarely present after the first month of life; older animals tend to either be carriers or asymptomatic. The majority of herds have some level present, with transmission likely happening during or shortly after birth. Clinical Signs Diarrhea - Pale Yellow, Bloody Dehydrated Dull calves Reluctant to drink Prevention/Treatment: The ideal scenario is to prevent infection through, sanitary facilities (calving barn), outdoor calf housing, and a good vaccination program. Colostrum will provide much needed antibodies, protecting the calf before their immune system is fully developed to combat the disease. Farmatan fed prior to calving can help reduce the pathogen load of the cow, reducing the likelihood of transmission. Farmatan supplemented in the milk has been shown to decrease the virus' ability to cause infection and clinical disease. The best treatment for calves already presenting clinical disease is to administer oral fluids/electrolytes to rehydrate the calf. Learn more about the positive effect of Farmatan's active ingredient HERE. Salmonella Salmonella infection of cattle is caused by a variety of species within the family. While the disease is uncommon in cattle with little effect on calf health, it has massive implications for human health and food safety. The bacteria spreads through direct contact or contaminated feed & water. This disease is highly regulated by the USDA. The most severe cases of salmonella affect calves between the ages of 7-10 days old. Clinical Signs Diarrhea - Bloody (flakes of slough tissue), Watery, Mucus present Lethargic Fever Prevention/Treatment: Prevention is always the best option: provide clean water, feed, and bedding. Isolate infected animals, ensure adequate colostrum intake, and develop a vaccination program with your veterinarian. Treatment with antibiotics and fluids (oral or intravenous) greatly increases the survival rate of calves infected with Salmonella. Farmatan has been shown to help reduce the likelihood of infection by protecting the gut, and reduce recovery time of infected animals.  LEARN MORE ABOUT IMOGENE INGREDIENTS  PRODUCTS Paul Mitchell & Paul Martin on RFD TV Rural America Live!  Cattle Industry News USDA Gives Bleak Timeline For Mexico Cattle Restrictions According to MeatingPlace.Com, the USDA has confirmed there will be no holiday gifts for Mexican cattle producers this year. Earlier this month, APHIS restricted all Mexican animal commodity imports following the detection of New World screwworm (NWS) in a cow in the southern Mexican state of Chiapas. Mexico's chief veterinary officer alerted USDA in late November. Dr. Rosemary Sifford, the agency's chief veterinary officers, stated to media that APHIS's restrictions will “likely” remain in place through the holidays, with “full resumption of live animal movements” after incremental changes in early 2025. She went on to say that while the U.S. continues to work very closely with Mexico and has agreed to protocols, it will take some time to implement these due to multiple steps needed to resume trade. Additionally, USDA announced $165 million in emergency funding to protect U.S. livestock from NWS, which are fly larvae that infest living tissue and cause infection. Canada Plans For U.S. Trade War Canada's federal and state governments are planning measures in response to President-elect Donald Trump's threatened tariffs. Prime Minister Justin Trudeau met with provincial leaders to discuss retaliatory actions. Canadian Finance Minister Chrystia Freeland said after the meeting that "a number of premiers spoke out strongly in favour of a robust Canadian response to unjustified tariffs." In a social media post last month, Trump accused Canada and Mexico of allowing drugs and illegal immigrants into the United States and vowed to slap a 25% tariff on imports from both neighbors immediately on taking office on Jan. 20. Such an act would contradict the 2020 US-Mexico-Canada Agreement (USMCA), a modest update of the preceding North American Free Trade Agreement (NAFTA), which Trump signed during his previous term in the White House.   Low U.S. Beef Inventory Argues Against Tariffs A former Canadian Cattle Association president Dave Solverson has urged farmers north of the border to utilize their relationships with fellow beef producers to try to counter US President-elect Donald Trump's threatened tariffs. Solverson said with herds in both countries at their smallest in many decades, extending possible 25% tariffs on Canadian imports makes little sense in the beef business. He said sales of Canadian stock to U.S. packers and feedlot operators are an important source to fill in increasing production gaps especially in northern states, according to Solverson, who led the Canadian Cattle Association from 2014-16. Solverson recalled that the community of North American beef producers forged alliances a decade ago to oppose mandatory country-of-origin labelling. Those coalitions with both state and national producer groups “really proved beneficial for both sides,” he said. Canadian farmers were able to convince their U.S. counterparts “about how important it was that they could top up their pens with a good group of Canadian cattle.” Questions About USDA's Electronic EID Requirements Answered There are still lots of questions about USDA's Electronic EID requirements and if you are confused don't worry you are not alone. Merck Animal Health has fielded many questions about the new electronic (EID) rules for livestock moving across state lines. As a leading provider of EID tags and readers through their AllFlex Brand, Merck Animal Health is helping support cattle producers in their decision-making with expertise and solutions.  As part of that effort, Merck Animal Health has provided some clarity to the tagging system.  We have all of those links and easy to follow information HERE.  King Ranch Institute For Ranch Management Accepting Applicants for 2025 Wanting to make a change this upcoming year?  Well, we all do. The King Ranch® Institute for Ranch Management (KRIRM) offers the premier Master of Science in Ranch Management degree. They prepare those with a passion for ranching for the next step in their career as ranch business managers.  Their master's degree program offers a unique multidisciplinary approach to ranch management. They teach students how to manage ranches, but also how to progressively think their way to success and innovation for the industry. The King Ranch Institute for Ranch Management curriculum sharpens students' skills and knowledge in the areas of animal science, wildlife science, range science, business, accounting, finance, and leadership. External learning opportunities include summer internships at ranches across the United States, projects that focus on real issues facing partnering ranches, and workshops with industry professionals that cover a variety of ranch-related topics.  The King Ranch Institute for Ranch Management is seeking applicants for 2025 that have a Bachelor's degree and at least 2 years' work experience in ranching. If you're ready to take the next step and earn a Master's degree and fast forward your management career, They encourage you to apply. Click HERE for more information. Christmas Gift Ideas For That Hard To Shop For Person Great handmade items along with Ranch It Up swag and merch can be found online HERE! RanchChannel.Com Now Has The Futures Markets & New Listings Futures Markets RanchChannel.com now has futures markets at your fingertips!  Feeder Cattle, Live Cattle, Corn, Wheat, Soybeans, Soybean Oil, Milk Class IV, and Ethanol.  Information is provided by DTN and market information may be delayed by as much as 10 minutes.  Click Here for more information!   UPCOMING SALES & EVENTS Ressler Land & Cattle:  January 11, 2025 Spruce Hill Ranch:  February 6, 2025 Prairie Hills Gelbvieh:  February 8, 2025 Wasem Red Angus:  February 20, 2025 Vollmer Angus Ranch:  April 1, 2025 Jorgensen Land & Cattle:  April 21, 2025 World Famous Miles City Bucking Horse Sale: May 15 - 18, 2025   BULL SALE REPORT & RESULTS Churchill Cattle Company Van Newkirk Herefords Gardiner Angus Ranch Cow Camp Ranch Jungels Shorthorn Farms Ellingson Angus Edgar Brothers Angus Schaff Angus Valley Prairie Hills Gelbvieh Clear Springs Cattle Company CK Cattle Mrnak Hereford Ranch Frey Angus Ranch Hoffmann Angus Farms Topp Herefords River Creek Farms Upstream Ranch Gustin's Diamond D Gelbvieh Schiefelbein Farms Wasem Red Angus Raven Angus Krebs Ranch Yon Family Farms Chestnut Angus Eichacker Simmentals & JK Angus Windy Creek Cattle Company Pedersen Broken Heart Ranch Mar Mac Farms Warner Beef Genetics Arda Farms & Freeway Angus Leland Red Angus & Koester Red Angus Fast - Dohrmann - Strommen RBM Livestock Weber Land & Cattle Sundsbak Farms Hidden Angus Wheatland Cattle Company Miller Angus Farms L 83 Ranch U2 Ranch Vollmer Angus Ranch A & B Cattle Carter Angus Farms Roller Ranch Montgomery Ranch Jorgensen Farms DLCC Ranch Four Hill Farm North Country Angus Alliance Spruce Hill Ranch Wilson Angus Jorgensen Land & Cattle Motherlode Sale ISA Beefmasters JYJ Red Angus Jorgensen Land & Cattle, Legends Of The Fall Bull Sale Clear Springs Cattle Company FEATURING Paul Mitchell Imogene Ingredients https://www.imogeneingredients.com/ @farmatanusa Kirk Donsbach: Stone X Financial https://www.stonex.com/   @StoneXGroupInc    Mark Vanzee Livestock Market, Equine Market, Auction Time https://www.auctiontime.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ @LivestockMkt @EquineMkt @AuctionTime Shaye Koester Casual Cattle Conversation https://www.casualcattleconversations.com/ @cattleconvos Questions & Concerns From The Field? Call or Text your questions, or comments to 707-RANCH20 or 707-726-2420 Or email RanchItUpShow@gmail.com FOLLOW Facebook/Instagram: @RanchItUpShow SUBSCRIBE to the Ranch It Up YouTube Channel: @ranchitup Website: RanchItUpShow.com https://ranchitupshow.com/ The Ranch It Up Podcast is available on ALL podcasting apps. https://ranchitup.podbean.com/ Rural America is center-stage on this outfit. AND how is that? Tigger & BEC Live This Western American Lifestyle. Tigger & BEC represent the Working Ranch world and cattle industry by providing the cowboys, cowgirls, beef cattle producers & successful farmers the knowledge and education needed to bring high-quality beef & meat to your table for dinner. Learn more about Jeff 'Tigger' Erhardt & Rebecca Wanner aka BEC here: TiggerandBEC.com https://tiggerandbec.com/ #RanchItUp #StayRanchy #TiggerApproved #tiggerandbec #rodeo #ranching #farming References https://www.stonex.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ https://www.auctiontime.com/ https://gelbvieh.org/ https://www.imogeneingredients.com/ https://alliedgeneticresources.com/ https://westwayfeed.com/ https://medoraboot.com/ http://www.gostockmens.com/ https://www.imiglobal.com/beef https://www.tsln.com/ https://transova.com/ https://axiota.com/ https://axiota.com/multimin-90-product-label/ https://jorgensenfarms.com/ https://www.bredforbalance.com/ https://ranchchannel.com/ https://www.wrangler.com/ https://www.ruralradio147.com/ https://www.rfdtv.com/ https://thehappytoymaker.com/ https://www.meatingplace.com/Industry/News/Details/117199 https://www.meatingplace.com/Industry/News/Details/117192 https://www.meatingplace.com/Industry/News/Details/117172

From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus. Hosts: Kathy Spindler and Brianne Barker Guest: Mary Estes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Diarrhea induced by rotavirus NSP4 (Science) Minimal infective dose of rotavirus (Arch Virol) mRNA release from rotavirus particles (Nat Struct Biol) Norovirus vaccine (Clin Ther) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Pour accéder à l'intégralité de ce podcast et écouter chaque semaine un nouvel épisode du Quart d'Heure Véto, c'est très simple, il vous suffit de vous abonner en cliquant sur ce lien : https://m.audiomeans.fr/s/S-yUNSBZSR Notes et références Article : Eertink, L.G., Wang, D., Li, F. & Adam, E.N. (2024) Equine rotaviruses: A review of old and new. Equine Veterinary Education, 36, 217–224. Available from: https://doi.org/10.1111/eve.13934 Retrouvez toute la synthèse sur la fiche podcast juste ici : https://audmns.com/pdrnQUq Pour nous suivre : 1. Abonnez-vous à notre chaine pour profiter de l'intégralité des épisodes : Le Quart d'Heure Véto : décrypte et résume en moins de 15 min un article de biblio véto - Sur abonnement uniquement Le Véto du Mois : Partagez le temps d'une interview l'expérience de vétérinaires emblématiques de notre milieu, des rencontres conviviales, comme si nous étions dans votre salon au coin du feu. Podcasts bonus au fil des inspirations... 2. Le Scope Nous partageons avec vous nos dernières découvertes, inspirations, pistes de réflexion, nouveautés… À découvrir et utiliser dès maintenant, TOUT DE SUITE, dans votre quotidien de vétérinaire, de manager, de vie personnelle, de chef d'entreprise… Et tout cela en moins de 5 minutes top chrono un à 2 mardis par mois ! Je souhaite recevoir mon Scope : https://vetmasterclass.com/lescope/ 3. Contactez-nous, suivez-nous et donnez nous votre avis ! Des sujets que vous souhaiteriez approfondir, des références à partager, ou nous faire part de vos feed-backs : Abonnez-vous à notre chaine, donnez nous des étoiles, un commentaire et partagez autour de vous ! Sur notre site : https://vetmasterclass.com/ Sur Facebook : https://www.facebook.com/VmHorse Sur Instagram : https://www.instagram.com/vetmasterclass/ Sur YouTube : https://www.youtube.com/channel/UC18ovcWk9e-mFiTL34OQ03g Sur Linkedin : https://www.linkedin.com/company/vetmasterclass-horse/about/ Belle journée à tous, Et continuez à vivre votre métier avec Passion !

La consejera de Salud, María Martín, y la directora general de Salud Pública, Eva Martínez, han detallado las novedades del calendario oficial de vacunación en La Rioja.

Broadcast from KSQD Santa Cruz on 6-13-2024 Alzheimer's Disease and APOE4 Gene Listener asks about the APOE4 gene and its association with Alzheimer's disease in the light of a recent sensationalistic Nature publication. The impact of amyloid beta and TAU proteins on Alzheimer's pathology. Differences in Alzheimer's risk among different ethnic groups with APOE4 with emphasis on the importance of cholesterol levels as a risk multiplier. Advice for a listener's husband dealing with chronic back pain and sciatica Dr. Dawn presents a basic checklist for evaluating back pain symptoms and determining the need for urgent medical intervention. Potential causes are discussed such as spinal nerve compression from various sources. In this case, Dr. Dawn made a specific suggestion of McKenzie exercises and emphasized the importance of seeing a sports medicine doctor or physiatrist for a comprehensive evaluation. Dr. Dawn responds to a caller about managing knee osteoarthritis The role of glucosamine, chondroitin, and topical diclofenac in treatment. Discussion on non-pharmaceutical approaches like heat application and massage. Potential interventions like steroid injections, hyaluronic acid, platelet rich plasma and their benefits and risks. Dr. Dawn answers a question about dietary oxalates and their impact on kidney stones She emphasizes the importance of the oxalate content in foods and its limited role in kidney stone formation. She emphasizes the importance of hydration and maintaining a healthy microbiome. For specific dietary guidelines on oxalate in foods she suggests using oxalate.org. A concerned parent asks about aluminum and other vaccine adjuvants like formaldehyde for their infant's 2 month well child visit She expresses conflicting fears of being mischaracterized as a vaccine denier by merely expressing concern about vaccination for her infant. Dr. Dawn provides a breakdown of the necessity, immediate urgency and risks of each recommended vaccine (Hepatitis B, DTaP, Polio, Hib, Pneumococcal, Rotavirus) and suggests a social contextualization strategy to perhaps delay Polio, rotavirus and Hep B in this family's social context while emphasizing the importance of certain vaccinations to prevent serious illnesses. Dr. Dawn cites intriguing ambiguities in the literature that support the counterintuitive idea that smaller doses of aluminum may have a greater accumulation in tissues of brain and reproductive tissues than larger doses, and promises to research this further in a future program.

Rotavirus, a highly contagious virus that causes severe diarrhea and vomiting, used to kill more than half a million children annually. But the introduction of the rotavirus vaccine has slashed that number dramatically, saving hundreds of thousands of lives each year. Joining us in this episode is Paul Offit, MD, a co-inventor of one of the two most widely used rotavirus vaccines worldwide. Dr. Offit is a professor of pediatrics and vaccinology at the University of Pennsylvania and director of the Vaccine Education Center at the Children's Hospital of Philadelphia. A leading world expert on vaccines, he served on the FDA Vaccine Advisory Committee during the COVID-19 pandemic. He is the author of more than 15 books, most recently Tell Me When It's Over: An Insider's Guide to Deciphering Covid Myths and Navigating our Post-Pandemic World (2024). Over the course of our conversation, Dr. Offit shares what drew him to pediatrics, how he developed a vaccine that now saves hundreds of kids every day, the stringent process by which new medications are approved, the origins of vaccine hesitancy. Why public health communication failed during the COVID-19 pandemic, what we can do to restore public trust in medicine, and more.In this episode, you'll hear about: 2:24 - The harrowing experience Dr. Offit endured as a young child that inspired him to a seek a career in pediatrics6:40 - How Dr. Offit's research led to a successful rotavirus vaccine in 2006 10:46 - A brief history of vaccines16:40 - Why Dr. Offit chose to become a public advocate for vaccines 20:14 - Why vaccines have garnered such intense backlash from large proportions of the public 26:44 - Factors that have led to an erosion of trust in public health over the past four years33:01 - What Dr. Offit means when he talks about “following the science”40:35 - How public health officials can speak about scientific knowledge in a way that acknowledges uncertainty47:37 - The future of vaccines mandates in our society 54:16 - Dr. Offit's advice for building trust with skeptical parents Dr. Paul Offit is the author of 13 books, including Tell Me When It's Over: An Insider's Guide to Deciphering Covid Myths and Navigating our Post-Pandemic World (2024).Dr. Offit can be found on Twitter/X at @DrPaulOffit.Visit our website www.TheDoctorsArt.com where you can find transcripts of all episodes.If you enjoyed this episode, please subscribe, rate, and review our show, available for free on Spotify, Apple Podcasts, or wherever you get your podcasts. If you know of a doctor, patient, or anyone working in health care who would love to explore meaning in medicine with us on the show, feel free to leave a suggestion in the comments or send an email to info@thedoctorsart.com.Copyright The Doctor's Art Podcast 2024

We share how to keep scours from affecting your herd this calving season. Red Angus enthusiasts, step up, we introduce you to Wasem Red Angus. News, Markets and more on this all new episode of The Ranch It Up Radio Show. Join Jeff 'Tigger' Erhardt, the Boss Lady Rebecca Wanner aka 'BEC', and our crew as we bring you the latest in markets, news, and Western entertainment on this all-new episode of the Ranch It Up Radio Show. Be sure to subscribe on your favorite podcasting app or on the Ranch It Up Radio Show YouTube Channel. EPISODE 168 DETAILS Everyone has their breed of choice.  For whatever reason and experiences we've had, has led many of us picking certain breeds over others.  Today we explore the philosophy and goals around Wasem Red Angus.   Calving season is getting ready to start for many producers and for some others it is still a ways away yet.  Regardless, we need to get a jump on scours and make sure each and every calf that hits the ground has the best chance of survival.  A simple solution… FARMATAN from Imogene Ingredients.   As always we have the latest market reports and recaps from Kirk Donsbach with Stone X Financial, Inc. along with news and updates you need to hear.  It's all covered on this brand new episode of The Ranch It Up Radio Show!   WASEM RED ANGUS The Wasem family started ranching in 2004 in Halliday, North Dakota with a small herd of commercial Red Angus and Simmental cows. They decided to get into the registered Red Angus business and held their first bull sale in 2012.  Each year they keep back the best registered heifers to expand the registered herd and to improve our genetics.  They strive to offer cattle with power and performance through balanced EPD's and phenotype.  Disposition is a must in the herd.  They are proud to be selling Red Angus Bulls in North Dakota. They welcome you out any time to look at cattle. Family Business Here at Wasem Red Angus, we are truly a family operation.  Each one of us has a job on the ranch and work together to make the operation a success.  Chris is in charge of many of the daily tasks, including feeding, planting, and harvesting.  Jolyn works on record-keeping and marketing.  Kacee is the number 2 cook in the house, quickly making her way to the top.  Braelyn is the one who makes us all laugh.  There are many days on the ranch, we need a good laugh!  The girls have been a huge asset working cattle the past few years, they are learning about low-stress livestock handling, as well as becoming good horsemen.  We wouldn't be able to get everything done without the help of family, friends, and neighbors throughout the year and we are grateful for those relationships.  Customer Service Customer service is really important to us. The relationships we build don't end the day of the sale. We stand behind the Red Angus Bulls we sell, and your happiness is important! WHAT CAUSES SCOURS IN BEEF CATTLE/CALVES Clostridia-Enterotoxemia The most common form of Clostridium in cattle is caused by Clostridia perfringens. The gram-positive bacteria are a challenge due to its ability to form spores and lay dormant for long-periods of time. The bacteria reproduce by releasing spores into its environment (soil, feed, manure). The spores can even lay dormant in the animal's intestine until opportunity presents itself. Infection takes place either through ingestion of spores or through an open wound. The most severe cases happen within the first month of a calf's life, and can result in sudden death. Clinical Signs • Diarrhea - Bloody, Mucus Present, Bubbly • Dehydrated • Bloat • Blindness Prevention/Treatment: Prevention can be difficult due to the Clostridia spores being extremely durable and present almost everywhere. Complete cleanout and disinfection between calves is helpful, but not always effective. A good vaccination program will reduce clinical disease. The best method is to develop good gut health and the immune system of the calf. Farmatan has been shown to strengthen the intestinal wall, helping to prevent infection from taking hold. Coccidiosis Cattle are host to numerous species of Coccidia, a single-celled protozoal parasite. Infection and clinical symptoms can happen any time during a calf's life, with the most severe reaction usually occurring between 3-6 weeks of age. The life-cycle of coccidia requires time to infect the intestine causing destruction of the mucosal and epithelial lining. The oocytes mature outside the host in warm, moist environments before being consumed, causing infection of a new host. Clinical Signs • Diarrhea - Watery, Bloody • Depression • Weight Loss Prevention/Treatment: Prevention of Coccidiosis is possible by keeping young calves separate from older animals, providing clean water and feed, and dry conditions. Isolation of infected animals is key to preventing transmission. Keeping the pen dry is the most important step a farmer/rancher can take in preventing Coccidiosis. Treatment can have a good impact on reducing secondary disease, and speeding up recovery time. Farmatan has been shown to disrupt the reproductive cycle of Coccidia; and may help strengthen the intestinal wall to prevent infection, in both the cow and calf. Coronavirus Bovine Coronavirus is a ubiquitous, envelope-viral disease, causing respiratory and enteric infection. There are many serotypes for this virus, making it difficult to test for, and create a vaccine. Coronavirus can present as either diarrhea and/or respiratory illness; transmitted through nasal discharge and/or feces. Animal reservoirs continue to spread the disease, and make eradication almost impossible. Clinical disease will likely occur between days 10-14, and present for up to 4 days. Clinical Signs • Diarrhea - Watery • Nasal Discharge • Coughing Prevention/Treatment: Prevention is difficult due to wild animals transmitting the disease. Keeping wild animals out of animal enclosures is essential. Isolation of infected animals is critical to preventing the spread of Coronavirus. Adequate colostrum intake, along with a good vaccination program will help prevent clinical disease. Learn more about the positive effects of Farmtan's active ingredient on Coronavirus HERE. Cryptosporidium Cryptosporidium Parvum is a single-celled parasite responsible for causing infection in young calves. The infection takes place within the first four weeks of a calves' life, afterwards immunity has developed within the calf. The parasite is either passed from the cow or spread through infected water sources. Clinical Signs • Diarrhea - Watery, Bloody, Mucus present • Colic • Depression Prevention/Treatment: Good sanitary conditions, especially clean water is essential in preventing transmission of cryptosporidium. Isolation of sick calves will help reduce the effect on the overall herd. There is some good effect of calves given adequate colostrum, however this is likely helping by reducing other pathogenic loads rather than a direct effect on Cryptosporidium, itself. Farmatan fed prior to calving has been shown to disrupt the life-cycle and reduce transmission from the cow. The direct action of Farmatan on the parasite makes it an excellent choice for treating calves. Learn more about the positive effect of Farmatan's active ingredient HERE. E. Coli Escherichia Coli is a bacterial infection that affects calves within the first week of their life. The bacteria colonize in the lower intestine and produce a toxin. The toxin causes excessive secretion of fluids. The zoonotic disease has special importance in food safety and human health. Colostrum and natural immunity are often not sufficient in preventing infection in cases of high bacterial concentrations. Clinical Signs • Diarrhea - Creamy, Yellow • Abdominal Pains • Fever • Vomiting Prevention/Treatment: The best prevention methods for E. Coli include: clean water, dry bedding/environment, isolation of infected animals, and vaccination. Treatment with antibiotics and oral fluids have great benefits in reducing clinical symptoms of the disease. Farmatan has been shown to reduce bacterial load and help prevent infection. Learn more about the positive effects of Farmatan's active ingredient HERE. Rotavirus Rotavirus in calves is caused by a virus belonging to the Reoviridae family, as a non-enveloped RNA virus. Rotavirus is thought to be the most common cause of neonatal diarrhea in calves. The virus tends to affect calves between the age of 1-day-old up to a month, with most cases presenting within the first week of life. Shedding and reinfection can happen in older calves and cows. Clinical symptoms are rarely present after the first month of life; older animals tend to either be carriers or asymptomatic. The majority of herds have some level present, with transmission likely happening during or shortly after birth. Clinical Signs • Diarrhea - Pale Yellow, Bloody • Dehydrated • Dull calves • Reluctant to drink Prevention/Treatment: The ideal scenario is to prevent infection through, sanitary facilities (calving barn), outdoor calf housing, and a good vaccination program. Colostrum will provide much needed antibodies, protecting the calf before their immune system is fully developed to combat the disease. Farmatan fed prior to calving can help reduce the pathogen load of the cow, reducing the likelihood of transmission. Farmatan supplemented in the milk has been shown to decrease the virus' ability to cause infection and clinical disease. The best treatment for calves already presenting clinical disease is to administer oral fluids/electrolytes to rehydrate the calf. Learn more about the positive effect of Farmatan's active ingredient HERE. Salmonella Salmonella infection of cattle is caused by a variety of species within the family. While the disease is uncommon in cattle with little effect on calf health, it has massive implications for human health and food safety. The bacteria spreads through direct contact or contaminated feed & water. This disease is highly regulated by the USDA. The most severe cases of salmonella affect calves between the ages of 7-10 days old. Clinical Signs • Diarrhea - Bloody (flakes of slough tissue), Watery, Mucus present • Lethargic • Fever Prevention/Treatment: Prevention is always the best option: provide clean water, feed, and bedding. Isolate infected animals, ensure adequate colostrum intake, and develop a vaccination program with your veterinarian. Treatment with antibiotics and fluids (oral or intravenous) greatly increases the survival rate of calves infected with Salmonella. Farmatan has been shown to help reduce the likelihood of infection by protecting the gut, and reduce recovery time of infected animals.  LEARN MORE ABOUT IMOGENE INGREDIENTS  PRODUCTS Paul Mitchell & Paul Martin on RFD TV Rural American Live!  FEATURING Chris Wasem, Wasem Red Angus https://www.wasemredangus.com/ @WasemReds   Paul Mitchell Imogene Ingredients https://www.imogeneingredients.com/farmatanusa @farmatanusa   Kirk Donsbach: Stone X Financial https://www.stonex.com/   @StoneXGroupInc      Mark Van Zee  Livestock Market, Equine Market, Auction Time https://www.auctiontime.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ @LivestockMkt @EquineMkt @AuctionTime   Shaye Koester Casual Cattle Conversation https://www.casualcattleconversations.com/ @cattleconvos Questions & Concerns From The Field? Call or Text your questions, or comments to 707-RANCH20 or 707-726-2420 Or email RanchItUpShow@gmail.com FOLLOW Facebook/Instagram: @RanchItUpShow SUBSCRIBE to the Ranch It Up YouTube Channel: @ranchitup Website: RanchItUpShow.com https://ranchitupshow.com/ The Ranch It Up Podcast available on ALL podcasting apps. Rural America is center-stage on this outfit. AND how is that? Because of Tigger & BEC... Live This Western Lifestyle. Tigger & BEC represent the Working Ranch world by providing the cowboys, cowgirls, beef cattle producers & successful farmers the knowledge and education needed to bring high-quality beef & meat to your table for dinner. Learn more about Jeff 'Tigger' Erhardt & Rebecca Wanner aka BEC here: TiggerandBEC.com https://tiggerandbec.com/ #RanchItUp #StayRanchy #TiggerApproved #tiggerandbec #rodeo #ranching #farming References https://www.stonex.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ https://www.auctiontime.com/ https://gelbvieh.org/ https://www.imogeneingredients.com/ https://alliedgeneticresources.com/ https://westwayfeed.com/ https://medoraboot.com/ https://www.bek.news/dakotacowboy http://www.gostockmens.com/ https://www.lucky7angus.com/ https://www.bredforbalance.com/ https://www.wasemredangus.com/ https://ranchchannel.com/

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Rotavirus ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Start the new season off with the most success you can by keeping scours away for good!  Plus we pack this one with news updates from Capitol Hill, export updates and forecasts for 2024.  Join Jeff 'Tigger' Erhardt, the Boss Lady Rebecca Wanner aka 'BEC', and our crew as we bring you the latest in markets, news, and Western entertainment on this all-new episode of the Ranch It Up Radio Show.  Be sure to subscribe on your favorite podcasting app or on the Ranch It Up Radio Show YouTube Channel. EPISODE 162 DETAILS Scours attacks on day 1 of a calf's life.  The best remedy is to be proactive versus reactive, and we have the solution for you.  It is Farmatan from Imogene Ingredients!  But here is the kicker.  It is not an overnight magic cure all.  We need to get this into the cows diet 60 to 90 days prior to calving to get maximum results.  It is simple and easy.  Just ask your feed supplier for Farmatan.  You can feed in a lick tub form, as a liquid, in a TMR ration, and/or free choice.  We go through the details and success stories with Paul Mitchell with Imogene Ingredients, who brings us Farmatan.  Bec shares news from Capitol Hill, beef import information from Paraguay, and the WASDE Report for the 2024 forecast.  But that's not all.  We have market updates, sale barn reports and lots more, even some Christmas gift ideas from the crew from Medora Boot and Western Wear.  And our Top Hand this week goes to Cracker Johnson.  Hear his story!  We have it all for you in this jam-packed episode of The Ranch It Up Radio Show!  As always Tigger & BEC and the Ranch It Up crew dive into the latest agriculture news, rodeo action not to miss, and cover the cattle markets. WHAT CAUSES SCOURS IN BEEF CATTLE/CALVES Clostridia-Enterotoxemia The most common form of Clostridium in cattle is caused by Clostridium perfringens. The gram-positive bacteria are a challenge due to its ability to form spores and lay dormant for long-periods of time. The bacteria reproduce by releasing spores into its environment (soil, feed, manure). The spores can even lay dormant in the animal's intestine until opportunity presents itself. Infection takes place either through ingestion of spores or through an open wound. The most severe cases happen within the first month of a calf's life, and can result in sudden death. Clinical Signs • Diarrhea - Bloody, Mucus Present, Bubbly • Dehydrated • Bloat • Blindness Prevention/Treatment: Prevention can be difficult due to the Clostridia spores being extremely durable and present almost everywhere. Complete cleanout and disinfection between calves is helpful, but not always effective. A good vaccination program will reduce clinical disease. The best method is to develop good gut health and the immune system of the calf. Farmatan has been shown to strengthen the intestinal wall, helping to prevent infection from taking hold. Coccidiosis Cattle are host to numerous species of Coccidia, a single-celled protozoal parasite. Infection and clinical symptoms can happen any time during a calf's life, with the most severe reaction usually occurring between 3-6 weeks of age. The life-cycle of coccidia requires time to infect the intestine causing destruction of the mucosal and epithelial lining. The oocytes mature outside the host in warm, moist environments before being consumed, causing infection of a new host. Clinical Signs • Diarrhea - Watery, Bloody • Depression • Weight Loss Prevention/Treatment: Prevention of Coccidiosis is possible by keeping young calves separate from older animals, providing clean water and feed, and dry conditions. Isolation of infected animals is key to preventing transmission. Keeping the pen dry is the most important step a farmer/rancher can take in preventing Coccidiosis. Treatment can have a good impact on reducing secondary disease, and speeding up recovery time. Farmatan has been shown to disrupt the reproductive cycle of Coccidia; and may help strengthen the intestinal wall to prevent infection, in both the cow and calf. Coronavirus Bovine Coronavirus is a ubiquitous, envelope-viral disease, causing respiratory and enteric infection. There are many serotypes for this virus, making it difficult to test for, and create a vaccine. Coronavirus can present as either diarrhea and/or respiratory illness; transmitted through nasal discharge and/or feces. Animal reservoirs continue to spread the disease, and make eradication almost impossible. Clinical disease will likely occur between days 10-14, and present for up to 4 days. Clinical Signs • Diarrhea - Watery • Nasal Discharge • Coughing Prevention/Treatment: Prevention is difficult due to wild animals transmitting the disease. Keeping wild animals out of animal enclosures is essential. Isolation of infected animals is critical to preventing the spread of Coronavirus. Adequate colostrum intake, along with a good vaccination program will help prevent clinical disease. Learn more about the positive effects of Farmtan's active ingredient on Coronavirus HERE. Cryptosporidium Cryptosporidium Parvum is a single-celled parasite responsible for causing infection in young calves. The infection takes place within the first four weeks of a calves' life, afterwards immunity has developed within the calf. The parasite is either passed from the cow or spread through infected water sources. Clinical Signs • Diarrhea - Watery, Bloody, Mucus present • Colic • Depression Prevention/Treatment: Good sanitary conditions, especially clean water is essential in preventing transmission of cryptosporidium. Isolation of sick calves will help reduce the effect on the overall herd. There is some good effect of calves given adequate colostrum, however this is likely helping by reducing other pathogenic loads rather than a direct effect on Cryptosporidium, itself. Farmatan fed prior to calving has been shown to disrupt the life-cycle and reduce transmission from the cow. The direct action of Farmatan on the parasite makes it an excellent choice for treating calves. Learn more about the positive effect of Farmatan's active ingredient HERE. E. Coli Escherichia Coli is a bacterial infection that affects calves within the first week of their life. The bacteria colonize in the lower intestine and produce a toxin. The toxin causes excessive secretion of fluids. The zoonotic disease has special importance in food safety and human health. Colostrum and natural immunity are often not sufficient in preventing infection in cases of high bacterial concentrations. Clinical Signs • Diarrhea - Creamy, Yellow • Abdominal Pains • Fever • Vomiting Prevention/Treatment: The best prevention methods for E. Coli include: clean water, dry bedding/environment, isolation of infected animals, and vaccination. Treatment with antibiotics and oral fluids have great benefits in reducing clinical symptoms of the disease. Farmatan has been shown to reduce bacterial load and help prevent infection. Learn more about the positive effects of Farmatan's active ingredient HERE. Rotavirus Rotavirus in calves is caused by a virus belonging to the Reoviridae family, as a non-enveloped RNA virus. Rotavirus is thought to be the most common cause of neonatal diarrhea in calves. The virus tends to affect calves between the age of 1-day-old up to a month, with most cases presenting within the first week of life. Shedding and reinfection can happen in older calves and cows. Clinical symptoms are rarely present after the first month of life; older animals tend to either be carriers or asymptomatic. The majority of herds have some level present, with transmission likely happening during or shortly after birth. Clinical Signs • Diarrhea - Pale Yellow, Bloody • Dehydrated • Dull calves • Reluctant to drink Prevention/Treatment: The ideal scenario is to prevent infection through, sanitary facilities (calving barn), outdoor calf housing, and a good vaccination program. Colostrum will provide much needed antibodies, protecting the calf before their immune system is fully developed to combat the disease. Farmatan fed prior to calving can help reduce the pathogen load of the cow, reducing the likelihood of transmission. Farmatan supplemented in the milk has been shown to decrease the virus' ability to cause infection and clinical disease. The best treatment for calves already presenting clinical disease is to administer oral fluids/electrolytes to rehydrate the calf. Learn more about the positive effect of Farmatan's active ingredient HERE. Salmonella Salmonella infection of cattle is caused by a variety of species within the family. While the disease is uncommon in cattle with little effect on calf health, it has massive implications for human health and food safety. The bacteria spreads through direct contact or contaminated feed & water. This disease is highly regulated by the USDA. The most severe cases of salmonella affect calves between the ages of 7-10 days old. Clinical Signs • Diarrhea - Bloody (flakes of slough tissue), Watery, Mucus present • Lethargic • Fever Prevention/Treatment: Prevention is always the best option: provide clean water, feed, and bedding. Isolate infected animals, ensure adequate colostrum intake, and develop a vaccination program with your veterinarian. Treatment with antibiotics and fluids (oral or intravenous) greatly increases the survival rate of calves infected with Salmonella. Farmatan has been shown to help reduce the likelihood of infection by protecting the gut, and reduce recovery time of infected animals.  COW COUNTRY NEWS Meat industry takes aim at UN's anti-meat claims at COP28 House Coalition Opposes Plan To Accept Importation Of Paraguay Beef WASDE Livestock Report For 2023   SALE BARN REPORTS Stockmens Livestock Exchange, Dickinson, ND   TOP HAND Chad “Cracker” Johnson   FEATURING Paul Mitchell Imogene Ingredients https://www.imogeneingredients.com/farmatanusa @farmatanusa   Austin Henderson Stockmen's Livestock Exchange Dickinson, ND http://www.gostockmens.com/ https://www.cattleusa.com @gostockmens   Shaye Koester Casual Cattle Conversation https://www.casualcattleconversations.com/ @cattleconvos   Chad “Cracker” Johnson https://crackerauctionservice.com/   Kirk Donsbach: Stone X Financial https://www.stonex.com/   @StoneXGroupInc      Mark Van Zee  Livestock Market, Equine Market, Auction Time https://www.auctiontime.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ @LivestockMkt @EquineMkt @AuctionTime Questions & Concerns From The Field? Call or Text your questions, or comments to 707-RANCH20 or 707-726-2420 Or email RanchItUpShow@gmail.com FOLLOW Facebook/Instagram: @RanchItUpShow SUBSCRIBE to the Ranch It Up YouTube Channel: @ranchitup Website: RanchItUpShow.com https://ranchitupshow.com/ The Ranch It Up Podcast available on ALL podcasting apps. Rural America is center-stage on this outfit. AND how is that? Because of Tigger & BEC... Live This Western Lifestyle. Tigger & BEC represent the Working Ranch world by providing the cowboys, cowgirls, beef cattle producers & successful farmers the knowledge and education needed to bring high-quality beef & meat to your table for dinner. Learn more about Jeff 'Tigger' Erhardt & Rebecca Wanner aka BEC here: TiggerandBEC.com https://tiggerandbec.com/ #RanchItUp #StayRanchy #TiggerApproved #tiggerandbec #rodeo #ranching #farming References https://www.stonex.com/ https://www.livestockmarket.com/ https://www.equinemarket.com/ https://www.auctiontime.com/ https://gelbvieh.org/ https://www.imogeneingredients.com/ https://alliedgeneticresources.com/ https://westwayfeed.com/ https://medoraboot.com/ https://www.bek.news/dakotacowboy http://www.gostockmens.com/ https://www.usda.gov/oce/commodity/wasde https://www.meatingplace.com/Industry/News/Details/112513 https://hpj.com/2023/12/05/house-coalition-opposes-plans-to-accept-importation-of-paraguay-beef/ https://hpj.com/2023/12/01/wasde-livestock-report-showed-lower-production-in-2023/ https://crackerauctionservice.com/

On episode #36 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 8/17 – 8/30/23. Host: Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Detection of rotavirus in respiratory specimens from children aged under 2 years hospitalized for acute gastroenteritis (JID) Risk of Bell's palsy following SARS-CoV-2 infection (CMI) Evaluation and management of diabetes-related foot infections (CID) Impact of mandatory infectious disease specialist approval on Clostridioides difficile infection rates and testing appropriateness (CID) Role of cerebral imaging on diagnosis and management in patients with suspected infective endocarditis (CID) Identifying effective durations of antibiotic therapy for the treatment of carbapenem-resistant Enterobacterales bloodstream infections (CID) Impact on clinical outcome of follow-up blood cultures and risk factors for persistent bacteraemia (CMI) State-of-the-art review: Neurosyphilis (CID) Oritavancin compared to the standard of care for treatment of non-endovascular gram-positive bloodstream Infections (OFID) How to approach suppressive antibiotic therapy following debridement, antibiotics, and implant retention for prosthetic joint infection (CID) 2023 Duke-International Society for cardiovascular infectious diseases criteria for infective endocarditis (CID) Adjunctive diagnostic studies completed following detection of candidemia in children (JPIDS) Oral lipid nanocrystal amphotericin b for cryptococcal meningitis (CID) Efficacy of 23 commonly used liquid disinfectants against Candida auris (IC&HE) Burrow ink test for scabies (NEJM) Evolution of partial resistance to artemisinins in malaria parasites in Uganda (NEJM) Human neural larva migrans caused by Ophidascaris robertsi ascarid (EID) Music is by Ronald Jenkees

Pemerintah Ditantang Capai Target Imunisasi Rotavirus yang Kini Masuk Program Nasional | Kejagung Tetapkan Anggota Komisi I DPR Ismail Thomas Tersangka Pemalsuan Dokumen Tambang | AJI Bandung Desak Polisi Usut Kasus Penganiayaan Jurnalis saat Liput Kerusuhan Dago Elos *Kami ingin mendengar saran dan komentar kamu terkait podcast yang baru saja kamu simak, melalui surel ke podcast@kbrprime.id

Rotavirus is a major cause of childhood disease and death in India. In 2016, the Government of India began a phased introduction of the rotavirus vaccine, and by 2019, the vaccine had been scaled up to cover the entire country. In this interview, Rebecca Chase, a Program Officer with JSI's Immunization Center, speaks with Dr. Arup Deb Roy, Project Director, and Dr. Amanjot Kaur, Senior Program Officer, both with JSI Private Limited's new vaccine introduction team, about their experiences working the Ministry of Health and Family Welfare to introduce the rotavirus vaccine in India. They discuss the challenges and successes of introducing a new vaccine in a large country like India and how their approach could be replicated for future vaccines.

On episode #27 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/13 – 4/25/23. Hosts: Daniel Griffin and Sara Dong Click arrow to play Download Puscast 027 (19 MB .mp3, 31 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Prevalence, clinical severity, and seasonality of Adenovirus 40/41, Astrovirus, Sapovirus, and Rotavirus among children with moderate-to severe diarrhea (CID) Antibiotic-prescribing practices for management of childhood diarrhea in 3 sub-Saharan African countries (CID) Drivers of decline in diarrhea mortality (CID) Breastfeeding among people with HIV in North America (CID) Wearable sensor-based detection of Influenza in presymptomatic and asymptomatic individuals (JID) Emergence of erythromycin-resistant invasive group a Streptococcus (EID) Piperacillin-Tazobactam compared With Cefoxitin as antimicrobial prophylaxis for pancreatoduodenectomy (JAMA) VE303 for prevention of recurrent Clostridioides difficile infection (JAMA) Geographic patterns of antimicrobial susceptibilities for Bacteroides species worldwide (IJAA) Intravenous to oral antibiotic switch therapy among patients hospitalized with community-acquired pneumonia (CID) Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalized with suspected gastroenteritis (The Lancet) Treatment of pulmonary mucormycosis with adjunctive nebulized amphotericin B (Mycoses) Giardia detection and codetection with other enteric pathogens in children in the vaccine impact on diarrhea in Africa (CID) Feasibility of training community health workers to use smartphone-attached microscopy for point-of-care visualization of soil-transmitted helminths (AJTMH) Compassionate use of bacteriophages for failed persistent infections (OFID) Music is by Ronald Jenkees

In this podcast, an experienced conference and webinar moderator is joined by two doctors in the field of paediatric infectious diseases: David Greenberg and Maria Hemming-Harlo. In this podcast, our guest experts provide information and their perspectives on the following topics: The disease burden of rotavirus The related morbidity and mortality of rotavirus How rotavirus is transmitted The clinical picture of rotavirus infection The evidence supporting routine vaccination with RotaTeq (Rotavirus Vaccine, Live, Oral, Pentavalent) This podcast was funded by Merck Sharp & Dohme LLC. Below please find the reference list for Vax Voices, Podcast 1: The Global Burden of Rotavirus Disease and Evidence Supporting Routine Vaccination With RotaTeq to ensure listeners can further explore the content discussed. View the product information and indication for RotaTeq here. View the Select Safety Information from MSD below. Select Safety Information RotaTeq should not be administered to infants with a demonstrated history of hypersensitivity to the vaccine or any component of the vaccine. Infants with a history of intussusception or who have congenital malformation of the gastrointestinal tract that could predispose infants to intussusception should not receive RotaTeq. Infants with Severe Combined Immunodeficiency Disease or SCID should not receive RotaTeq. Administration of RotaTeq should be postponed in infants suffering from acute severe febrile illness. The presence of a minor infection is not a contraindication for immunisation. The administration of RotaTeq should be postponed in subjects suffering from acute diarrhoea or vomiting. No safety or efficacy data are available from clinical trials regarding the administration of RotaTeq to infants who are potentially immunocompromised. Cases of gastroenteritis associated with vaccine virus have been reported post marketing in infants with severe combined immunodeficiency. Vaccine virus transmission from vaccine recipient to nonvaccinated contacts has been reported. Caution is advised when considering whether to administer RotaTeq to individuals with immunodeficient contacts. In post-marketing experience, intussusception (including death) and Kawasaki disease have been reported in infants who have received RotaTeq. As a precaution, healthcare professionals should follow-up on any symptoms indicative of intussusception (severe abdominal pain, persistent vomiting, bloody stools, abdominal bloating and/or high fever) since data from observational studies indicate an increased risk of intussusception, mostly within 7 days after rotavirus vaccination. Parents/guardians should be advised to promptly report such symptoms to their healthcare provider. The level of protection provided by RotaTeq is based on the completion of all 3 doses. As with any vaccine, vaccination with RotaTeq may not result in complete protection in all recipients. HQ-ROT-00133 | 02/23   Podcast References: 1.Nelson R. COVID-19 disrupts vaccine delivery. Lancet Infect Dis. 2020;20(5):546. 2.Centers for Disease Control and Prevention (CDC). Epidemiology and Prevention of Vaccine-Preventable Diseases. 14th ed. Chapter 19: Rotavirus. Available at: https://www.cdc.gov/vaccines/pubs/pinkbook/rota.html. Last accessed: 6 March 2023. 3.Dormitzer PR. "Rotaviruses," Mandell GL, et al, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier Saunders; 2019:1983-96. 4.Centers for Disease Control and Prevention (CDC). Rotavirus. Clinical information. 2021. Available at: https://www.cdc.gov/rotavirus/clinical.html. Last accessed: 13 October 2022. 5.Troeger C et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr. 2018;172(10):958-965. Erratum in: JAMA Pediatr. 2022;176(2):208. 6.GBD Diarrhoeal Diseases Collaborators. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis. 2017;17(9):909-948. Erratum in: Lancet Infect Dis. 2017 Sep;17(9):897. 7.Van Damme P et al. Rotavirus vaccines: considerations for successful implementation in Europe. Lancet Infect Dis. 2006;6(12):805-12. 8.Paul MO, Erinle EA. Influence of humidity on rotavirus prevalence among Nigerian infants and young children with gastroenteritis. J Clin Microbiol. 1982;15(2):212-5. 9.Finnish Institute for Health and Welfare. Infectious diseases and vaccines: rotavirus vaccine. 2020. Available at: https://thl.fi/en/web/infectious-diseases-and-vaccinations/vaccines-a-to-z/rotavirus-vaccine. Last accessed: 16 September 2022. 10.GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117-71. 11.Franco MA et al. Immunity and correlates of protection for rotavirus vaccines. Vaccine. 2006;24(15):2718-31. 12.Gentsch JR et al. Serotype diversity and reassortment between human and animal rotavirus strains: implications for rotavirus vaccine programs. J Infect Dis. 2005;192(Suppl 1):S146-59. 13.Merck & Co. RotaTeq®. Prescribing information. 2022. Available at: https://www.merck.com/product/usa/pi_circulars/r/rotateq/rotateq_pi.pdf. Last accessed: 4 January 2023. 14.European Medicine Agency (EMA). RotaTeq. Summary of product characteristics. 2022. Available at: https://www.ema.europa.eu/en/documents/product-information/rotateq-epar-product-information_en.pdf. Last accessed: 4 January 2023. 15.Velasquez-Portocarrero DE et al. Head-to-head comparison of the immunogenicity of RotaTeq and Rotarix rotavirus vaccines and factors associated with seroresponse in infants in Bangladesh: a randomised, controlled, open-label, parallel, phase 4 trial. Lancet Infect Dis. 2022;22(11):1606-16. 16.Cortese MM, Parashar UD; Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2009;58(RR-2):1-25. 17.Vesikari T et al.; Rotavirus Efficacy and Safety Trial (REST) Study Team. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006;354(1):23-33. 18.Vesikari T et al. Efficacy of a pentavalent rotavirus vaccine in reducing rotavirus-associated health care utilization across three regions (11 countries). Int J Infect Dis. 2007;11(Suppl 2):S29-35. 19.Heyse JF; REST Study Team. Evaluating the safety of a rotavirus vaccine: the REST of the story. Clin Trials. 2008;5(2):131-9. 20.World Health Organization (WHO). Rotavirus vaccines: WHO position paper. Wkly Epidemiol Rec. 2021;96(28):301-20.  

In this episode, Emma Adam, DVM, PhD, DACVIM, DACVS, talks about the discovery of Rotavirus B in foals and offers tips for managing foaling mares. “Disease Du Jour” is brought to you in 2023 by Merck Animal Health.

In this episode, Emma Adam, DVM, PhD, DACVIM, DACVS, talks about the discovery of Rotavirus B in foals and offers tips for managing foaling mares. “Disease Du Jour” is brought to you in 2023 by Merck Animal Health.

Dr. Van der Meer's contact information if you are a Western Canadian cow-calf producer interested in participating in his field study on causes of calf diarrhea:     frank.vandermeer@ucalgary.ca00:00 – 2:34   Welcome and Introductions 2:35 – 4:20   The importance of neonatal calf diarrhea4:21 – 5:39 Pathogens involved in neonatal calf diarrhea5:40 –7:37 Can you diagnose the cause of neonatal calf diarrhea clinically?7:38 – 14:11 Coronavirus and Rotavirus as causes of calf diarrhea14:12 - 16:29 Treating calves with viral diarrhea16:30 - 22:23 Challenges with developing effective viral vaccines for neonatal calf diarrhea22:24 – 26:50 Where do these viruses come from and the importance of booster vaccines26:51- 31:39 Current field study on causes of calf diarrhea31:40 – 32:48   Wrap up 

Dr. Uneeda Bryant describes how veterinary pathologists safeguard horse populations, determine causes of death, and protect the human-animal bond.This podcast series is brought to you by Zoetis.About the Researcher: Uneeda Bryant, DVM, is a tenured associate professor of veterinary pathology at the University of Kentucky's Veterinary Diagnostic Lab, in Lexington. She earned her veterinary degree from Tuskegee University College of Veterinary Medicine, in Alabama. In addition to her responsibilities as a pathologist and teaching role as adjunct faculty for Lincoln Memorial University College of Veterinary Medicine, Dr. Bryant works regularly to educate the public about this nontraditional veterinary medicine career path.Show Notes:Veterinary Pathologist Recognized on Kentucky Senate FloorEquine Tyzzer's DiseaseAn Update on Rotavirus in FoalsUKVDL Goes Mobile to Educate KentuckiansThe University of Kentucky's Veterinary Diagnostic LabMare Reproductive Loss Syndrome

THE THESIS: People are serving the Enemy and they may not even think he exists. THE SCRIPTURE & SCRIPTURAL RESOURCES: John 8: 44-4644 You belong to your father, the devil, and you want to carry out your father's desires. He was a murderer from the beginning, not holding to the truth, for there is no truth in him. When he lies, he speaks his native language, for he is a liar and the father of lies. 45 Yet because I tell the truth, you do not believe me! 46 John 9:4239 Jesus said, “For judgment I have come into this world, so that the blind will see and those who see will become blind.”THE NEWS & COMMENT:Amazon.com sells SUICIDE KITS to kids? Last Friday, CBS cancelled a segment about our clients suing Amazon for selling suicide kits to their now deceased kids. CBS' cowardice gave me renewed clarity about how urgent this litigation is.State Surgeon General Dr. Joseph A. Ladapo Issues New Mrna COVID-19 Vaccine GuidanceTallahassee, Fla. — Today, State Surgeon General Dr. Joseph A. Ladapo has announced new guidance regarding mRNA “vaccines.” The Florida Department of Health (Department) conducted an analysis through self-controlled case series, which is a technique originally developed to evaluate vaccine safety.This analysis found that there is an 84% increase in the relative incidence of cardiac-related death among males 18-39 years old within 28 days following mRNA vaccination. With a high level of global immunity to COVID-19, the benefit of vaccination is likely outweighed by this abnormally high risk of cardiac-related death among men in this age group. Non-mRNA vaccines were not found to have these increased risks.As such, the State Surgeon General recommends against males aged 18 to 39 from receiving mRNA COVID-19 vaccines. Those with preexisting cardiac conditions, such as myocarditis and pericarditis, should take particular caution when making this decision.“Studying the safety and efficacy of any medications, including vaccines, is an important component of public health,” said Surgeon General Dr. Joseph Ladapo. “Far less attention has been paid to safety and the concerns of many individuals have been dismissed – these are important findings that should be communicated to Floridians.”[AUDIO] - Nice vignette (with mega-billionaire Bloomberg & statist apparatchik Lagarde) of how Davos Crowd elites talk about the serfs. They might as well be discussing Koi fish here. Mike explains how he'll use very regressive taxes to extend your pathetic life.Is the Pilot Working? RNC Says Google Sent Over 20M GOP Emails to SPAM in 6 Days“A March North Carolina State University study exposed that Gmail marked 67.6 percent of right-leaning candidates' emails as spam and just 8.2 percent of left-leaning candidates' emails as spam.” PayPal Updates User Policy to Include Possible $2,500 Fine For Speech It Doesn't Like' “PayPal's clause about taking users' funds for a violation of its rules has long been established. But […] effective on November 3rd, 2022, PayPal will add restrictions to its acceptable use policy that go beyond illegal activities and fraud and into the realm of policing speech.” – via Reclaim the Net.A psycho vagrant attacked a woman in Prospect Park, sprayed her with urine and killed her dog. And this is how the New York Times writes about it[AUDIO] - NEW: Suspect accused of kidnapping Merced family was previously convicted for an oddly similar case. I spoke with one of the 2005 robbery victims, who told me Jesus Salgado held him at gunpoint, duct taped his family's hands, & told them “if you call the police I'll kill you”[AUDIO] - Dr Aseem Malhotra: ''Why are [the mRNA shots] not being pulled?"Swine Flu jab ('76) - Pulled after a 1 in 100,000 risk of Guillain-Barré syndrome.Rotavirus jab ('99) - Pulled after a 1 in 10,000 risk of bowel obstructionCovid jab - Serious adverse events between 1 in 800 and 1 in 1000

KSQD 10-05-2022: All about dry eye disease -- diagnosis and treatments; Rotavirus vaccine helps protect babies from developing type 1 diabetes; Can hypnosis help me reduce waking up at night to pee? How does the uterus not contract prematurely during pregnancy? A review of deep magnetic brain stimulation for depression and other brain conditions; Steroid injections are associated with rapid hip degeneration, but causality is not clear; Platelet rich plasma for joint pain is very popular now

Episode 1962: Our featured article of the day is Rotavirus.

The federal government has commenced free vaccination of children below one year of age in the country with RotaVirus vaccines. Global health report showed that Rotavirus is one of the leading causes of diarrhoea disease in the world and is responsible for over 40 per cent of the infection in children. The Executive Director of the National Primary Health Care Development Agency Dr Faisal Shuaib, says approximately 50,000 deaths occur in children under five years in Nigeria annually as a result of Rotavirus infection. He says Nigeria has the second highest number of deaths from rotavirus, accounting for 14 per cent of all childhood rotavirus deaths worldwide.

In this week's episode, we discuss the "ACR's 2022 Guideline Summary for Vaccinations in Patients with Rheumatic and Musculoskeletal Diseases" with lead author Dr. Anne Bass, Attending Physician in the Division of Rheumatology at Hospital for Special Surgery and a Professor of Clinical Medicine at Weill Cornell Medicine. During our conversation we consider the importance of guidelines for vaccines, the impact certain drugs like rituximab and methotrexate have on vaccinations, cover some vaccine highlights within the guidelines, how these guidelines can aid in navigation with insurance companies and much, much more. 

Paul Offit is a doctor who helped create the Rotavirus vaccine, credited with saving millions of lives worldwide. He joins The Compass the give us an update on Covid, how the vaccine is working so far, and his thoughts on why it is still important to be vaccinated.

Paul Offit is a doctor who helped create the Rotavirus vaccine, credited with saving millions of lives worldwide. He joins The Compass the give us an update on Covid, how the vaccine is working so far, and his thoughts on why it is still important to be vaccinated.

Dr. Carole Keim MD takes listeners through vaccines in today's episode. She explains everything from how vaccines are created to common myths and misconceptions about them. She then details each baby and childhood vaccine, and what disease each prevents.Dr. Keim breaks down how vaccines work and what criteria they must meet in disease to be effective. She explains the four main types of vaccines and lays each vaccination out in a clear manner, covering what age your baby or child will be when they receive the vaccine and how the immune response works. These vaccines are proven to protect your baby against everything from tetanus to mumps to pertussis and more.This episode will cover: How vaccines workCriteria to create a vaccineThe 4 different types of vaccinesCommon myths or misconceptions about vaccinesSpecific vaccines (all routine childhood vaccines)Total number of vaccinesCommon side effects and red flags, how to treat How vaccines work: 00:44The purpose of vaccines is to trigger an immune response faster and with less harm than the original disease.The immune system is a lot like a microscopic team of superheroes, made up of white blood cells, antibodies, the complement system, and a few others.  These superheroes fight villains such as bacteria, viruses, and other pathogens.  If they cannot fight them fast enough, the villains will multiply and cause symptoms of disease.  Vaccines give your superhero team information about what the villains look like, so they can recognize them as soon as they enter the body, and fight them off quicker and easier.Vaccine criteria: 01:26In order to make a vaccine, certain conditions must be metIt has to be effective.  We must be able to become immune to the pathogen; diseases like RSV and HFM are ones we can catch multiple times.  Chickenpox is one that you become immune to after catching it once.The pathogen must not be able to mutate faster than the vaccine can be given - we do flu boosters annually because the flu virus mutates about that often.  HIV and common cold mutate too fast for a vaccine to be developed.The vaccine must be cost-effective; it has to be cheaper to prevent the disease than to treat itThere are 4 main types of vaccines: 02:31Inactivated (killed pathogens)Live attenuated (weakened pathogens)Toxoid (a piece of what's inside the pathogen)mRNA vaccines Inactivated vaccines 03:44Most common typeThe bacteria or viruses in the vaccine are killed, so your immune system can safely learn to recognize the pathogen that it is trying to fight off.  These vaccines do not have the potential to cause actual disease.  What they do is cause the immune system superheroes to practice fighting the villains, kind of like practicing on dummies, which may cause mild signs of illness - fever, sore muscles, crankiness, or other symptoms.  Examples: IPV (polio), HPV (human papillomavirus), HiB (Haemophilus influenzae B), pneumococcus (Streptococcus pneumoniae), meningococcus (Neisseria meningitidis), and Hepatitis A and B vaccines.Live attenuated vaccines 04:02Made from bacteria or viruses that have been exposed to chemicals that make them weaker than the natural or “wild type” bacteria or virus.  Since these pathogens are not killed completely, your superheroes aren't just practicing on dummies, they are actually fighting the weakened villains.  So it is possible to have symptoms of the disease, but milder.  Some people with weakened immune systems may not be able to fight them off, and can get the actual disease.  People taking steroid medications or immune suppressants, or who have HIV or other immune deficiencies should consult a doctor about whether it is safe to receive these vaccines.  Examples: oral polio vaccine, MMR (measles, mumps, and rubella), Varicella zoster (chickenpox), and rotavirus vaccines.Toxoid vaccines 04:55Made from just part of the pathogen, and protect against the kinds of bacteria that cause symptoms after the toxins inside them are released.  These toxin-carrying bacteria are like villains carrying around a bottle of poison, and the toxoid vaccine gives the superheroes the poison to sample and build up resistance to it.  Example: DTaP (diphtheria, tetanus, and acellular pertussis).MRNA vaccines 05:23Newest typemRNA is like a copy of instructions. These give your immune system something like a sewing pattern to print out and make the dummies for your body to fightExample: some COVID vaccinesMyths and misconceptions about vaccines: 05:45Many parents have concerns about vaccinating their children.  It only takes one serious reaction to call into question the safety of vaccines.  And it has been so long since the vaccine-preventable diseases have run rampant that we in the United States don't fully understand the scope of what is being prevented.  Here are some of the top concerns that I have heard from parents, and the truth behind them.Aluminum.  There is aluminum in vaccines, but the amount is far less than babies get from other sources.  The total amount of aluminum that babies get from vaccines in the first 6 months is 4.4mg.  Breastfed babies consume 7mg, formula-fed babies consume 38mg, and babies on soy formula consume 114mg of aluminum in the first 6 months of life.  Consuming aluminum vs. having it injected in a vaccine looks the same to the body, so the tiny amount of aluminum in vaccines will not harm your babyAntigens.  An antigen is any microscopic substance that has the possibility to elicit an immune response.  Babies are exposed to over a trillion antigens in the first year that naturally occur in the environment.  The entire vaccine series that children receive today contains just over 150 antigens.  A young baby's immune system can easily recognize these few antigens and make antibodies to the diseases without getting sick.Autism.  It has been proven that vaccines do NOT cause autism.  The age that children first start showing signs and can be tested for autism is 15-24 months.  This is the same age that children receive booster vaccines, so it is understandable that some parents think they are related. Long-term protection.  Vaccines will protect a person for just as long as if they got the original disease.  So a person who had chickenpox as a child is just as protected from getting it again as a person who has received the chickenpox vaccine.  Some people do not seroconvert (develop antibodies to that disease) - that depends on their immune system and is not a failure of the vaccine itself.Mercury.  There used to be a preservative called thimerosal in vaccines.  That preservative (which contains mercury) has been removed from all vaccines in the US that children receive.  The only vaccine that still contains thimerosal is the adult flu vaccine.Unnatural exposure.  Some people worry that getting exposed to a disease through an injection is not the same as getting it “naturally” by being exposed to a sick person.  This is not true; any disease will get into your bloodstream, which is where it is recognized by the body, and once in there the body has no idea how it got in.  So getting an injection looks exactly the same to your immune system as getting the disease from a sick person.Doctors DO NOT get paid to vaccinate childrenVaccines are NOT a punishment for children who are behaving badlySpecific vaccines: 10:47Hep B - 0, 2, 6 mos.  Hepatitis B is a viral infection that can be passed from mom to baby through the placenta or during delivery.  90% of babies born with HepB will develop chronic infection and are at risk of liver cancer later in life.DTaP - 2, 4, 6, 15 mos, 4 years.  Tdap - age 11, every 10 years.  DTaP has more diphtheria, Tdap has more tetanus. Bacterial infections.  Diphtheria causes severe sore throat and enlarged tonsils, and can block the airway from swelling/tonsils being so enlarged.  Tetanus makes spores that live in soil; any penetrating wound could have tetanus in it (nail/thumbtack, dog or cat bite) and tetanus is not killed by antibiotics so it must be prevented.  Pertussis is whooping cough and causes babies less than a year old to stop breathing.  Everyone who takes care of the baby should be current on their TDaP (within 10 years).  Polio - 2, 4, 6 mos, 4 years.  Polio is a virus that attacks nerves and causes paralysis.  Sometimes it's minor, and sometimes it's the diaphragm that's affected and they stop  breathing.  There is no specific treatment for polio.HiB - 2, 4, 6, 12-18 mos.  HiB (haemophilus influenzae B) bacterial infection that affects children less than 5 years, and especially those under 1 year of age.  It used to cause severe infections like epiglottitis, sepsis, pneumonia, and meningitis.  PCV - 2, 4, 6, 12-18 mos.  PCV = pneumococcal conjugate vaccine, pneumococcus is another name for streptococcus pneumonia, which is a kind of strep that gets into the bloodstream and causes sepsis, pneumonia, and meningitis.  PCV has 13 strains of strep in it right now.Rotavirus - 2, 4, 6 mos. Viral infection that causes severe diarrhea and dehydration in babies. Hep A - 12 and 18 mos. Hep A is a type of food poisoning, there's no specific treatment.  MMR - 1 and 4 years.  Measles causes high fever, rash, and can cause brain damage, hearing loss, and death.  Mumps causes parotitis (infection of salivary glands), but in boys also causes orchitis (inflammation of testicles) and can lead to sterility.  Rubella is a fever and rash; more dangerous to unborn babies, causes miscarriages and birth defects.VZV - 1 and 4 years.  Varicella Zoster virus (chickenpox) causes cold symptoms, fever, and an itchy and painful rash in children, and shingles in adults.  VZV in pregnancy causes miscarriages and birth defects.MCV - 11 and 16 years.  Meningitis A, C, W, Y are viruses that cause inflammation around the brain that develops quickly and can be fatal.  HPV - 11 years.  Human papilloma virus causes warts and dysplasia and can lead to cancer of the mouth, throat, anus, cervix, and penis.  Currently 9 strains of HPV in the vaccine.  Flu: recommended annually COVID: recommendations are still evolvingVaccines that are available but not given routinely: MenB, PPSV23, Dengue, Typhoid, japanese encephalitis, yellow fever, rabiesTotal numbers of vaccines: 22:351 at birth (Hep B)2 mos: DTaP, polio, HiB, Hep B, PCV, rotavirus - 1 or 2 combo vaccines, PCV and rota = 2 or 3 shots plus an oral vaccine4 mos: DTaP, polio, HiB, PCV, rotavirus - 1 combo plus PCV and rota = 2 shots and one oral6 mos: DTaP, polio, HiB, Hep B, PCV, rotavirus - 1 or 2 combo vaccines, PCV and rota = 2 or 3 shots plus an oral vaccine6+ mos: flu vaccine annually12-18 mos: 2 doses Hep A, 1 of DTaP, HiB, PCV, MMR, VZV.  5-7 shots depending on combos.4-6 years: DTaP, polio, MMR, VZV, typically given as 2 combo vaccines11 years: Tdap, MCV, 2 doses HPV16 years: MCV21+ years: Tdap every 10 years; booster if you have a wound and it's been less than 5 years, booster while pregnant9 shots and 3 oral before 1 year of age, 5-7 shots from age 1-2, 2 shots age 4-6, 4 at age 11, 1 at age 16 = 21-23 total shots before adulthood.  18 flu shots.  Common vaccine reactions: 23:53Birth: nothing; sometimes redness/swelling2-6 mos: redness and swelling (local reaction), can be as much as the entire thigh and still be considered normal.  Low grade fevers.12-18 mos and 4-6 years: muscle soreness, MMR and VZV cause fevers, VZV sometimes causes rash, other vaccines can cause local reactions11yrs: muscle soreness, local reaction with Tdap and MCV, fainting with HPV16 yrs: local reaction from MCVTdap boosters: muscle sorenessFlu, COVID: flu-like symptomsIt is NOT normal to have a body rash or vomiting after vaccines; those are signs of allergyLarge local reactions and muscle soreness can be treated with cool compresses (wet washcloth) and/or acetaminophen or ibuprofen.  Fever or flu-like symptoms: acetaminophen or ibuprofenI DON'T recommend pre-medicating your child before vaccinesIf your child has an adverse reaction to a vaccine, you should report it to VAERS (vaccine adverse event reporting system).  Remember that VAERS is like Yelp for vaccines, so take that about as seriously as you would a Yelp review.All of this information is also in The Baby Manual book, which is available for purchase. Remember it is always okay to call your doctor or emergency services if you have concerns about your baby's health.  Resources discussed in this episode:The Baby Manual - Available on AmazonVAERS--Dr. Carole Keim MD: linktree | tiktok | instagram

On month two, your child is set, per the CDC schedule, to receive MANY more vaccines.On top of a booster for the Hep B that we discussed last week, one of the next vaccines is the infamous Rotavirus.  The Rotavirus is a virus that the CDC claims every single child will eventually get at some point in their life.  Do we REALLY need this vaccine? Does it work? It the Rotavirus really a virus to fear? This week we dive into all the details on the Rotavirus itself and the vaccine, diving into risks and benefits of both.Subscribe and hang out with me every Wednesday to stay up to date on this show.  If you enjoy, please share this on your social media and tag me (@brookebrewer20) and give me a rating/review. Thank you!For Text updates when each episode releases textPODCAST to (248) 301-9919 Sponsors:Get your Fat Burning Collagen today (linked the chocolate flavored goodness)https://modere.co/3jxbzyBUse code 4842132 to save $10 off your first orderShow notes and references: Current CDC Vaccine Schedulehttps://www.cdc.gov/vaccines/schedules/index.htmlFDA website for package inserts: https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htmVaccine Ingredient Summary https://vaccine.guide/vaccine-ingredients/overview/cdc-vaccine-excipient-and-media-summary/Vaccine Glossery and Detailshttps://vaccine.guide/vaccine-ingredients/overview/vaccine-ingredient-glossary-and-details/Harvard Study on VAERS reporting https://vaccine.guide/ncvia-vicp-vaers/vaccine-adverse-events-reporting-system/hhs-funded-vaers-investigation/Rotavirushttps://www.cdc.gov/vaccines/pubs/pinkbook/downloads/rota.pdfVAERS for Rotavirus https://www.cdc.gov/mmwr/preview/mmwrhtml/mm4827a1.htmDiarrheahttps://emedicine.medscape.com/article/928598-overview#a8Rotavirus Inserthttps://www.fda.gov/media/75718/download

Die Rotavirus-Impfung: sie findet so früh im Leben unserer Kinder statt, dass sie vor lauter Stress in den ersten Wochen oft vergessen oder nicht wahrgenommen wird. Rotavirus-Infektionen sind aber nicht nur in ärmeren Ländern der Welt ein Problem, sondern gehören auch in Deutschland zu den häufigsten Auslösern einer Magen Darm Infektion. Das Für und Wieder und vor allem worauf du während und nach der Impfung achten musst, erfährst du in der heutigen Folge. Der Werbepartner der heutigen Folge ist KoRo, das Onlineportal für haltbare und gesunde Lebensmittel. KoRo besticht durch faire Preise, Nachhaltigkeit und wenig Verpackung. Mit dem Rabattcode NIKOLA5 bekommt ihr 5% Rabatt auf das gesamte KoRo-Sortiment. Schau dich um unter https://www.korodrogerie.de/ Wie hat dir die Folge gefallen? Du findest diesen Podcast bei Spotify, iTunes und Deezer. Ich freu mich über deine Gedanken, Fragen und Input auf meinem Instagram Kanal oder auf meiner Website. Hier geht es zu unseren Online Kursen: https://www.kinderleibundseele.com/online-kurse Wenn dir die Folge gefallen hat, freu ich mich riesig über eine Bewertung bei Apple Podcasts ! Teile diese Folge gerne mit anderen Eltern, die nach Antworten auf Fragen zur Kindergesundheit suchen. Disclaimer: Sämtlich Inhalte auf kinderleibundseele dienen der allgemeinen Information. Alle Informationen auf dieser Seite sind sorgfältig recherchiert, können jedoch in medizinischer Hinsicht keinerlei Anspruch auf Vollständigkeit, Aktualität, Richtigkeit und Ausgewogenheit erheben. Insbesondere sind sie in keiner Weise ein Ersatz für professionelle Diagnosen, Beratungen oder Behandlungen durch Ärzte/Ärztinnen. Genauso wenig dürfen die hier angebotenen Informationen als Grundlage für eigenständige Diagnosen sowie Behandlungen oder Änderungen an einer bereits empfohlenen Behandlung dienen. Konsultiere bei gesundheitlichen Fragen oder Beschwerden immer den behandelnden Arzt/behandelnde Ärztin. kinderleibundseele übernimmt keine Haftung – weder direkt noch indirekt – für Schäden oder Unannehmlichkeiten, die sich aus der Nichtbeachtung dieser Hinweise ergeben.

Wow! It has already been 2 months since your baby made its way into this great big world. Now is the time to get that all-important 2-month checkup done along with mom's 6 week postpartum appointment, come find out what Dr. Carole Keim MD has in store for you today on The Baby Manual: vaccine protection against diseases like rotavirus; important questions answered about resuming pre baby activities work, etc., but don't worry she still covers eating, peeing, pooping, and skincare routines.The first vaccines: DTaP (Diphtheria, Tetanus, Pertussis), Polio, Hib (Haemophilus influenzae type B), Hep B(Hepatitis B), PCV (Pneumococcal conjugate), rota (Rotavirus). Again we cover the importance of tummy time and ways you can help your baby with their development.Parents (00:23)Starting to resume pre-pregnancy activities and interests, plan return to school or workGetting out with the baby Partner support?  Family support?Mom should have had 6-week postpartum checkupTalk with partner about family planning Hold, cuddle, talk and sing to your babyDevelop strategies for crying Eating (02:48)6-8x per 24 hours, 24-30oz per 24hCan take 4-6oz at a time and be full 4-6 hoursPeeing/pooping (03:23)They have found their pattern: typical 1-2x per day, the rule of 7's still applies: once per week up to 7x per day is normalPeeing with each feed, 6-8x per 24hSkin (04:06) Bathing 1-2x per weekCan use lotion or cream or ointment after bathsDiaper rash - if it lasts more than 2-3 days despite normal diaper cream (zinc-oxide-based like Desitin or petroleum-based like Vaseline or Aquaphor) it might be infected.Candida (yeast/fungal) - solid pink area with tiny pinpoint-sized pink dots around it (satellite lesions). Can try mixing apple cider vinegar and water 1:1, OTC antifungal cream, or call a doctor for a prescription for Nystatin.Bacterial infection: pimples or boils, often MRSA, can try applying Neosporin TID but if it doesn't help, they need mupirocin TID.  Treat the whole family - nails and nose.2 month checkup (08:27)Baby should have gained about 2lbs since last checkup (avg weight 11lb)First vaccines: DTaP, Polio, Hib, Hep B, PCV, rota (2-3 shots, one oral)Neuro/devel: diminishing grasp/tone/moro reflexes, attempts to look at parent, smiles, able to console self, begins to have different types of crying, coos, able to push up a little during tummy time, consistent head control while supported in upright positionAnticipatory guidance - Eating: nothing but breast milk or formula until 4-6 months; wait for our next visit before feeding anything else Sleep: back to sleep, no blankets, put baby to bed awake but drowsySafety: never leave baby on high surfaces, use rear-facing car seat until age 2, avoid secondhand smoke, set water temp to 120'F to avoid scald burns, don't prop bottleDevelopment: tummy timeNext checkup is at 4 months of age and we will do all the same vaccines except they don't need another Hep B at that time (17:43)Resources discussed in this episode:The Baby Manual - Available on Amazon--Dr. Carole Keim MD: linktree | tiktok | instagram

What is the best way to combat today's healthcare problems? What illness is attacking your body? Is it the Coronavirus, flu, flurona, RSV, or Rotavirus? Is it possible for all these illnesses to attack at once? What is the best way to combat them? Is getting vaccinated the right choice for me? Is our society going to get through this pandemic? Listen today for information to understand healthcare and scientific research. Additionally, our hosts will give you some tips to protect against the possibility of attacks on the immune system. 

Should you take a full course of antibiotics? What about Tylenol for headaches? Do vaccines cause autism? Dr. Paul Offit, pediatrician & director of the Vaccine Education Center at the Children's Hospital of Philadelphia, member of the FDA's advisory panel approving COVID vaccines, and co-inventor of the rotavirus vaccine helps us dissect the anti-vaccine movement whose roots extend far before COVID. We'll also take a close look at common medical fallacies and discuss what the future of the COVID-19 pandemic holds. Thanks for listening, and we hope you enjoyed the episode! ---- FOLLOW US:

TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene. Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment Alan – Sokobond puzzle game Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene. Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment Alan – Sokobond puzzle game Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this episode Dr. Emma Adam of the University of Kentucky describes the research that identified a novel strain of rotavirus in foal diarrhea cases this year.This podcast is the twelfth episode in our “Equine Innovators” podcast series, brought to you by Zoetis.Show notes:An Update on Rotavirus in FoalsSessions from the 2021 Rotavirus Workshop, funded by the University of Kentucky's CAFE Gluck Equine Research Center Koller Emergency Response Funds and gifts from the Kentucky Thoroughbred Association/Kentucky Thoroughbred Owners and Breeders, Coolmore America, and Grayson Jockey Club.The Gluck Equine Research CenterThe Gluck Center's newsletters, Equine Science Review and Equine Disease QuarterlyPractical Biosecurity Tips to Protect Your HorseInfographic: Protecting Your Horse From DiseaseAbout the Researcher: Emma Adam, DVM, PhD, Dipl. ACVIM, ACVS, is an assistant professor at the University of Kentucky's (UK) Gluck Equine Research Center and the equine outreach veterinarian for UK's Department of Veterinary Science. Her career focuses on the health and wellbeing of the equine athlete and she has worked in four countries on three continents. Adam received her veterinary degree from the Royal Veterinary College, in the U.K., after which she gained equine internal medicine specialty training at Texas A&M University and equine surgery specialty training at the University of Pennsylvania's New Bolton Center. She completed her PhD research in regenerative medicine as it relates to articular cartilage using RNA sequencing at the Gluck Center. Her primary role now is to connect the university with equine industry stakeholders through outreach and the dissemination of information.

Dr. Emma Adam goes into depth about the discovery, research and current treatments for this possible life-threatening type of foal diarrhea.

In 2010, two companies learned their vaccines for a childhood infection (rotavirus) had another virus present: porcine circovirus. Both companies couldn't detect the virus lurking in a key material used for vaccine manufacture, and it went undetected until an academic lab discovered with new technology. Virologist and Vaccine Developer Dick Hesse from Kansas State University joins me and Diane to discuss vaccine contamination.  We are also joined by Julia Schaar with Medgene Labs (https://www.medgenelabs.com/) a local livestock vaccine developer to share best practices for preventing product contamination.  

Tim and Susan are entrepreneurs at their core. Tim has been in the custom home construction business for his 25+ career, restoring and renovating both Residential and Commercial buildings. Whether it is damage from various pathogens, water, mold, or bacteria, he works with professional industrial hygienists that specialize in laboratory testing and clearance certification. In this changing landscape, Tim has decided he can help tremendously by stopping the Coronavirus in it's tracks, with The COVID KILLER!! The COVID KILLER has 3 systems that will destroy the Coronavirus: 1. Professional decontamination with electrostatic equipment. 2. UV-C lighting - medical grade appliances that not only destroy Viruses (COVID-19/Coronavirus) Influenza, Smallpox, Hepatitis, SARS, Ebola, MRSA, Noro HIV, Rotavirus, and many more. 3. Pure Air design that destroys the Viruses in the air.. whether it's in an HVAC unit that you have or a wall unit that is installed. This system constantly destroys Viruses in the air and provides pure air - Free from Viruses, Bacteria, Mold and Spores (VBMS) UV-C has been used for decades to destroy pathogens. VBMS is utilized in hospital surgical settings, food safety, and it treats our water supply. ~~~~ Susan Forster has been actively involved in the real estate industry for over 35 years and focuses on residential & investment properties in San Diego County. Susan and Tim have collaborated many times before, and this is their newest venture. Susan has owned and operated real estate brokerages in Orange County, Santa Cruz, Monterey, Pebble Beach, Maui, and San Diego. ~~~~ You can learn more about The COVID Killer at - www.pureairdesign.com Tim: www.rcdcustomhomes.com Susan Forster: here ~~~~ IN THIS EPISODE: 3:48       The COVID KILLER 4:38      " When it's dead, it can't spread!" 12:55    “You know, there's gotta be a fix … instead of this temporary fix… have a permanent fix.” 13:59    It's just it's critical that the country wakes up and understands 16:20    It's not a temporary fix. It's permanent. 17:45    We can fabricate any building… schools, restaurants, auditoriums, movie theaters, gyms, salons. 18:05     Put this on sound stages, studios, networks 20:25 Dr. Clark Henderson outfitted his office 21:03 The portable unit is like Robby the Robot on Grey's Anatomy 24:48   Retrofit older buildings 41:55    If we're dead, there is no economy 45:59   There are products for cars. Car dealers 46:50    Entertainment Tonight, Extra, The Chew: We want to help your studio!! ~~~~~~~~~~ YOUR FREE GIFT!! Centerpointe Research Institute creates neuro-audio tools like Holosync, and online personal development programs to help you become your happiest healthiest You. It's Centerpointe's 30th anniversary this year, and they're celebrating by giving away one of their most popular soundtracks. It's called "15 Minute Rescue and Renew" “15 Minute Rescue & Renew” will help you: Collect your emotionsReset your entire daySet a new pattern… …for handling stressful situations in the future. ​​Now you can totally reset your day in 15 minutes or less! ​15 Minute Rescue & Renew uses powerful Holosync technology (embedded beneath a soothing musical track with gentle ocean sounds) to alter brainwave states, bringing your brain down to… ​…a calm and tranquil “theta” state (feelings of deep relaxation and contentment). ​In addition, 15 Minute Rescue & Renew begins with a brief audible guide followed by powerful affirmations––recorded in Centerpointe's proprietary Autofonix™ encoding technology… …composed exclusively for this amazing soundtrack. (Just click HERE to receive your copy) This is exclusive to the listeners of The Art of Being Dar.

Rotavirus vaccine causes more issues than you'd think. Listen as I break it down.  For all the research and manuscripts plus research on all vaccines go to project 180, for a limited time it is free! www.goproject180.com  Follow me on instagram and facebook https://www.instagram.com/drstevenbaker/ https://www.facebook.com/1timothy4.11/ 

Rotavirus vaccine causes more issues than you'd think. Listen as I break it down.  For all the research and manuscripts plus research on all vaccines go to project 180, for a limited time it is free! www.goproject180.com  Follow me on instagram and facebook https://www.instagram.com/drstevenbaker/ https://www.facebook.com/1timothy4.11/ 

This episode covers gastroenteritis in children.Written notes can be found at https://zerotofinals.com/paediatrics/gastro/gastroenteritis/ or in the gastroenterology section in the Zero to Finals paediatrics.The audio in the episode was expertly edited by Harry Watchman.

What is a vaccine? How long will it take to get one for COVID-19? Are there are other alternatives? What about herd immunity? Our guest is Dr. Peter Khoury, the President and CEO of Ology Bioservices Inc. He is an expert on vaccines and biologics and during his 30-year career, he has worked for the Bill & Melinda Gates Foundation, Merck, and Baxter International. Dr. Khoury has involved in international forums on vaccines, pandemic planning, and biodefense preparation. TRANSCRIPT: Intro: 0:01 Inventors and their inventions. Welcome to Radio Cade the podcast from the Cade Museum for Creativity and Invention in Gainesville, Florida. The museum is named after James Robert Cade, who invented Gatorade in 1965. My name is Richard Miles. We’ll introduce you to inventors and the things that motivate them, we’ll learn about their personal stories, how their inventions work and how their ideas get from the laboratory to the marketplace. James Di Virgilio: 0:37 Welcome to another special edition of radio Cade. I’m your host James Di Virgilio. Today we’ll be discussing vaccinations and COVID-19, there’s a lot of information, misinformation questions that you have that we have. And with us today, we have an expert in the subject of not only vaccinations, but also manufacturing them. Dr. Peter Khoury. He is the president and CEO of Ology Bioservices Inc and that is located in Alachua, Florida. He’s been involved with vaccines and biologics for a majority of the 30 year career employed by organizations, such as the Bill and Melinda Gates foundation, Merck and Company and Baxter international. Dr. Khoury has been an invited speaker for many international forums concerning vaccines. Pandemic planning, biodefense preparation, and has worked on global threat programs against biologics with many ministries of health and oversight committees for large events, such as the Olympic committee. Dr. Khoury, thank you so much for joining us today. Dr. Peter Khoury: 1:34 Thank you for inviting me. James Di Virgilio: 1:35 So the role now that you and Ology are playing in the COVID-19 crisis is essentially to manufacture vaccinations amongst other things which are going to unpack, but it seems prudent to start with asking a simple question, but one that is now talked about a lot. What is a vaccine? Dr. Peter Khoury: 1:54 Probably the simplest answer is a vaccine is a protein that stimulates your immune system to induce immunity or induce antibodies. It’s exactly as if you were exposed to the disease. So when a healthcare worker gives a vaccination, they’re exposing your immune system to something that looks very similar to a particular virus or bacteria, which helps your immune system then react quickly when you’re exposed to the real infection, it has, what’s called immune memory and it remembers, ah , I’ve seen this before and it starts immediately in a sense, producing these antibodies to fight that infection. James Di Virgilio: 2:46 Now , these viruses, I’m a big fan of game theory are essentially alive in a sense, right? They’re adapting, they’re changing and your body’s doing the same. So if you get a good vaccine and it produces the proper, it’s possible that the virus then counters that with a different response of sorts, right? Depending on what we’re looking at, Dr. Peter Khoury: 3:06 It’s amazing that a virus can be that smart, that it quickly can adapt, or it’s in a sense survivor of the fittest. It’s just like an antibiotic. When you have antibiotic resistant organisms, let’s say you have a hundred bacteria and you put an antibiotic on it. It kills 99 of them, but there’s one that has a genetic sequence that makes that a little more difficult to kill. And if you don’t take the full 10 days of the antibiotics, that one tends to still live a little bit and start rowing . And all of a sudden you’ve got a big colony of this that is intermediately resistant. And then you take another dose of antibiotics for another 10 days, but only take five days of it. And you think it’s gone away out of those hundred. There’s one that’s now resistant. So it’s surprising how bacteria or virus can quickly adapt. It’s a numbers game is really what it is. There’s genetic mutations that will cause one of those virus to have mutated enough that it’s getting around your immune system in there for it’s called drifting and shifting when it does that. And you see that with influenza in a sense every year. And it’s a big guessing game on which strains of flu are included in the flu vaccine every year. If you’re lucky, you end up targeting a protein in the vaccine that does not mutate, and then you’re golden , you don’t have to worry about. James Di Virgilio: 4:42 And that’s a lot of what’s going on right now with COVID-19. So on one hand, you read articles, we’ve found the sequencing, we know what’s going on. And then on the other hand you read yet, but that’s really a small portion of the battle. We don’t know how it’s going to react when it’s put into live testing with human patients and subjects. When we’re talking about vaccinations, how successful against a novel virus like this one, which I believe shares a genome with SARS one to a large extent, but how successful are we? Once we identify step one, this is what it looks like and is at getting it to actually work in people. Dr. Peter Khoury: 5:17 That’s a great question. We are very fortunate as it seems that this Corona viruses not doing any real shifting or drifting at all, and you are correct. So the SARS and mirrors virus, so the sudden acute respiratory syndrome in the Mideast respiratory system viruses were also Corona viruses, which are a, I think it’s a genus or a species of virus themselves. And this is just another one. Now this one, for some reason, the human to human transmission has really taken off. And that’s why we’ve now see this pandemic. And they watch this pandemic cascade around the world. If there were this shifting or drifting, they’d be able to take samples from different areas and find out when they run a DNA gels, that there has been some changes in the sequences, but they’re not seeing that at all. So that’s very fortunate that we don’t see up that allows them vaccine R and D personnel to try many different approaches to developing a vaccine. And the most common youth approaches in the past were what they called an inactivated vaccine or killed vaccine, which they take it and they either irradiated or they chemically treat it till it’s killed. And then they inject it into you and your body will develop antibodies against that, or what’s called a live attenuated vaccine, which they select specifically for a strain of that virus that when you’re infected with it, you get what’s called a subclinical infection. You develop antibodies, but for some reason you don’t end up getting the fever and the respiratory problems and all of that. Instead, you just sorta produce the antibodies for it. And so those are widely used, but there are now some very complicated ways of addressing tough issues with vaccines. HIV for example, that’s been around since early eighties and still, there’s not a vaccine available for that. I always look at that as the big mystery for developing a vaccine, we were awarded a contract for what’s called a DNA vaccine, and this was with a company called Anovo. And this is one of those very complex approaches, which we feel very confident will work, where they take a piece of DNA that codes for what’s called a spike protein. They put it in a plasmid in, this is then put in a syringe and injected using a special type of what’s called electroporation, where it opens up your cell to take in this little piece of DNA in this circle called a plasmid and it uses your own cellular system to make the protein. So your body starts producing this protein, some of your cells do. And then your other cells that normally produce antibody will see this protein being made and start producing antibody against it. So it’s a unique approach. It can be done very quickly and low cost, and that seem important thing. And one of the reasons why this approach is being looked at. James Di Virgilio: 8:41 Now, how often would this type of approach be used and things people are familiar with vaccinations for like an influenza. And , and if you don’t know anything about vaccines and you’re more like me, like you mentioned, there’s like seven or eight or nine or 10 different types. There’s different ways you can create a vaccine. This is one of them. How often has this been used successfully in other. Dr. Peter Khoury: 9:02 So it’s very novel. I don’t know of a DNA vaccine yet that has been put on the market because it’s such a new approach. And in fact, if you look at all the vaccines that have been available for the last 30 years, all of them basically fit into five different approaches. The two that I had mentioned, and then there’s conjugation. There’s, polysaccharide, there’s another one that is escaping me just basically four or five different ways that vaccines are currently manufactured. So some of the ones that people are talking about now are these very novel biotech approaches that appear to be safer, faster, lower cost, ways of vaccinating. So I’m excited that this innovations finally being used and may produce a vaccine that is both affordable, can be produced in large quantity and available may be sooner than some of the older methods used. James Di Virgilio: 10:04 And let’s unpack some of that because if we were to find using a traditional method, the actual vaccine that works, we have to go through these different phases. So step one, we’re going to start with maybe animal testing or something similar. I know chicken eggs tends to be a big one with a lot of things, but you can’t do that with coronavirus. So that’s a problem that doesn’t work. And then I know that in only 16% of the cases, do you make it from phase one to phase three, with a working vaccine? And then how often does your vaccine work? It might only work 50% of the time. And is that good enough? Right? So you have all these hurdles to overcome. That’s why it takes a long time. 18 months tends to be the soonest. People think it can happen. How different is that with your solution potentially. Dr. Peter Khoury: 10:44 So ours also about 18 months, just the clinical study. So not talking about the preclinical animal studies, but when you actually get to the point where you’re starting to inject it in humans, it’s usually between six and eight years to get through the phase one, two and three. So phase one normally is just a very small study with a few adults to make sure that it’s safe. And they do some where they look at the effectiveness on those few people. And if no one kills over in a sense, or they’re getting some kind of immune response and there’s at least something that they can measure, they’ll go into phase two, which is larger, maybe a couple hundred people in some of those are age appropriate. Then. So if they’re trying to go down to infants, they’ll then throw in a few infants into that study and they’ll do, what’s called a dose ranging study and look at what’s the optimal dose that you would use for them. And they really start looking at the side effects and other things cause they have a larger pool to draw from once that’s through and they get the go ahead to go on to phase three, they go into this much larger trial than some of these, especially with infants can be tens of thousands because they’re trained to pick up the background noise, a very small number of crucial side effects that potentially could happen. And they’re taking very detailed measurements of how safe and effective it could be. Once it gets to that, it goes in front of the FDA. It gets approval for use or rejected, but usually by then, they’ve spent hundreds of millions of dollars. Hopefully it gets approved, but even then many companies commit to what’s called a phase four study, which is a post-marketing commitment to follow up with people that have been vaccinated and also submit to the FDA. Anytime there’s adverse events, send them information. So they keep track of it also. So it’s very useful. I’ve got to say for every vaccine that goes through, there’s probably 50 that don’t make it to the market. So there’s a lot of money spent on R and D. Our government’s been very good at funding, quite a bit of novel R and D, which has been great. Healthcare is expensive. There’s no doubt. We’re one of the few countries that really support innovative research and development. And I hope that people still continue to do that. I think that any shorter than a year and a half to do those studies, you would have to do it on what’s called a patient name basis where people would have to sign a form and say, I understand it hasn’t been fully tested, but I’m willing to take it untested because the risk benefit ratio to me is such that I’m willing to take on that risk. James Di Virgilio: 13:39 And that’s something like Ebola, right? When Ebola came out, people were saying, well, we can’t even have a control study because nobody wants to placebo. Just give me a chance with this vaccine versus letting this run its course, which creates difficulty in developing a vaccine. How often are these vaccine side effects worse than what we’re dealing with? Is that something that’s frequent or is it pretty unlikely that even a testing vaccine is worse than what someone would already have? Dr. Peter Khoury: 14:04 That’s a great question too. The only one that I can think of that they had some problems with. And if you go back and look at the data in hindsight, they had overreacted. Some was with the original Rotavirus vaccine, which is a terrible issue. It’s a diarrheal disease that infants get. And when they first did the studies, the studies looked fine, but it wasn’t picking up these incidents of what’s called intussusception, which is when the intestines fold in on themselves. And once they started using it widely around the United States, within the first two or three months, I had all these infants die of this intussusception they immediately pulled the vaccine from the market. People were in an uproar, but more children died of Rotavirus. And another great example is when you look at polio vaccine, so polio, which still hasn’t been eradicated, there’s still a few places around the world that have polio. They were using oral polio vaccine for years, but in one, in a million cases, when a child gets oral polio vaccine, it converts back into wild type polio. And the child actually ends up getting polio. So one in a million children end up getting polio from the vaccine, but the other 999,999 children are all protected and fine, but they were so upset about that one child that a lot of money has been spent to develop alternate vaccines for polio. James Di Virgilio: 15:41 Yeah. I find that to be interesting. And I’m really glad we’re talking about this now, because to me, everything in life is a risk reward continuum. It’s very rare that you get a very pure two. Plus two is four here all the time. This is the obvious decision. Most often, it’s that sort of decision. Well, if we do nothing, we have this. And if we do something it’s possible that we have this side effect, we don’t know, but what is better than starting with our baseline. And that’s a really good contextual answer. So it sounds like the majority of vaccines are not generally super risky, worse than what we’re trying to fix, but maybe they’re not as effective as others. So if I’m a company, big pharma or otherwise, and I want to manufacture this, right, we have the lab that discovers the vaccine. They come to me and they say, James, we want you to manufacture this. How likely am I to take this on? Because the numbers seem very low. It seems likely I’m going to lose a lot of money and not all of these outbreaks we’re dealing with. Come back again. So maybe I develop a vaccine and now it’s sort of just gone. How likely is it for companies to want to fund these initiatives? Dr. Peter Khoury: 16:39 That also was a great question because all we know right now is that we’re having a pandemic and we’re not clear whether it’s flattened out or not personally, I don’t think it has yet. And I think still may be the worst is yet to come. And I hope it doesn’t act like a influenza, a pandemic where you get a small wave. And then a few months later, maybe this fall or a little later, you get a much larger wave that travels around the world and will kill hundreds of millions instead of a million or two. So I’m just hoping this does not happen or that it takes on the route that influenza does where it’s North hemisphere for half the year, then goes down to the Southern hemisphere, then swings back up to the North. They’re not quite sure because we haven’t had the experience yet with this Corona virus. What they do now is it’s not like SARS. It’s not like MERS where it was here for a few months and then suddenly just sort of disappeared. This just seems to be staying. So with that, the question is, will it become a yearly vaccine for people. Will there eventually be some drifting of it. So they’ll have to be a new vaccine every year. How profitable will it be for companies? Will companies start looking at other emerging infectious diseases and start the research and development earlier, or will the government fund that early research and development? Because there are emerging infectious diseases around the world that we don’t have in the United States, but make some background noises in other areas that could easily be the next coronavirus . So when do you start investing in that? So you’re a year ahead of where you are now. James Di Virgilio: 18:32 And that’s a great topical point to discuss. You mentioned something earlier about research being done, and I’m not sure how many people know this, but the medical research done in the US and innovative work like you’re mentioning is a hundred times or whatever the number is. It’s so significantly more than anywhere else in the world. If you look at that graph, it’s the US and everyone else is tiny. I think Germany is second on that. And their infinitesimal compared to what’s done here. There’s a lot of negative emotions around what big pharma and other stuff does. And we’re not going to get into that. Other than to say that it is a fact that so many dollars in this country go towards trying to solve these problems. And then here we are with things that are unpredictable to a certain end. Now you worked for what maybe now has become the most famous right kind of foundation. There is with the Bill and Melinda Gates foundation, looking at trying to solve this problem. Bill Gates has been beating this drum for a long time. This is the biggest threat to humanity. What you just mentioned was sort of getting ahead of this. Is there a way for us, was there a way for us, will there be a way for us to sort of prescriptively try to get ahead of some of these things you just mentioned, things that are bubbling up elsewhere, we know kind of exist. How do we do that? Dr. Peter Khoury: 19:34 So there actually is a list that is kept by the government. The CDC has one, the world health organization has one . If you go on their websites, they talk about emerging infectious diseases. And in fact, the Gates foundation has an area that focuses on these emerging infectious diseases also. And so people do keep tabs on those large pharma, looks at them and says, there’s no value to us because we lose money, investing on things that we think are going to be valuable, but it’s just hard to solve the problem. You think of the billions of dollars that have been spent on HIV vaccine instill of course one is not available. So they think about that, but then they look at something that’s just emerging, especially if it’s in the developing world, they say, it’s just not worth that someone else should fund it. Gates foundation, fortunately does, which is great. The welcome trust is another, that does. So there are some that do that funding. The US government will fund some of them. If they feel that there may be a threat of it, either coming to the US especially some of the vector diseases that are transmitted through ticks or through mosquitoes, or could be used in biodefense, which is another area that people don’t pay that much attention to. We remember the anthrax scare and what happened. Then that’s another area that I think probably needs more focus from all governments. So both pandemic planning for other things than just influenza in also good preparation for biodefense. James Di Virgilio: 21:17 And there’s this interesting thing. When you think about humanity, that always strikes me. I’m an investor professionally, and with investing, nothing is black and white. It’s a lot of study of people and behavior and things that we know to be true. And one thing that is definitely true is we’re not very good at predicting anything as humans. In fact, we’re the most accurate at predicting the weather and we can go about 48 hours before that falls off a cliff of actually being significant statistically. So when it comes to these really complicated problems, I often think of the three body problem. You can know A, and you can know B and you can know everything about factor A and factor B, but you can’t know C you just can’t know where it is. And I think people sometimes pale to understand how complicated and chaotic these systems are. And just because we know A, and B does not mean that we can ever predict C, it’s not easy. It’s not simple. It’s not a one week or one month process. And even with our best foresight efforts, we may never get the prediction. Correct. And then there goes a lot of money into something that may yield nothing, right? And you’re kind of always doing this where, like you mentioned, do I put my dollar? So now that we’re facing COVID-19 and actively, we know we need to solve this problem. The engines are running, the creativity is going, innovation is happening. You are mentioning something that’s brand new right now with regards to trying to save this. And then there are also some other techniques out there. Tell me about using plasma from recovering patients to protect the most seriously ill what’s going on with that. Dr. Peter Khoury: 22:41 Yea I know that that has been on the news and it is an effective way of treating. So what they do is they take convalescent plasma from patients that have recovered, because it has antibodies in it. And those include antibodies that protect against COVID-19. And it’s a fast way of developing. What’s referred to as hyper immune state, where you have more antibodies than normally your body would produce. So they take the most ill people in, they’ll put in this convalescent plasma, which they know contains these antibodies while they contain a lot of antibodies and other things. But for sure it contains the antibodies that help that person recover from COVID-19 and it boosts their immune system of the target patient. That downside is the possibility of their body in a sense rejecting it, it can cause a negative immune response due to something in that plasma or in this has happened in the past a yet to be identified foreign item, which could cause issues to recipients later on. And that’s with anything that’s blood related. I mean, we saw it with HIV at the very beginning where people were getting blood transfusions, you saw with it mad cow disease at times where prions were transmitted through blood transfusions, but there is another solution. And actually we’re working on it. We were given a grant to work with the Vanderbilt University medical center to produce what’s called a monoclonal antibody. So what they do is they take the antibodies from a convalescent patient, and they’re able to find out which specific antibody is the one that works the best. And they clone only select for the cell or the piece of DNA that produces that protein, that codes for that antibody. And they’re able to replicate that in produce just that one antibody, and you can do it in big fermentors or bio-reactors. And you produce these monoclonal antibodies, which are all exactly the same and mass produced . Those had a fairly low cost that can be much faster than vaccines. Now you may see monoclonals before the end of the year, and those most likely will go to healthcare professionals, those immediately on the frontline for protection, and also those that are most critically ill would get these monoclonal antibodies. Those will definitely be lifesavers. And I suspect that the first will be out quite a bit before the vaccine will be, James Di Virgilio: 25:30 That’s like a triage solution, but not the best longterm. Is that a three ? Dr. Peter Khoury: 25:35 Yeah. It’s not long term because eventually your body will remove those antibodies. So you’re talking a few weeks protection when you’re talking a vaccine, you’re talking usually a much longer term protection of years, if not the rest of your life, sometimes vaccines. If they elicit a longterm immune response, you only get them once. And that’s that you’re protected the rest of your life. James Di Virgilio: 25:59 So the way out of this is seemingly to have a vaccine. That’s what people are saying. Dr. Peter Khoury: 26:03 It is. James Di Virgilio: 26:03 The world’s not going to truly relax into, we have a vaccine or this just maybe mysteriously disappears, which seems very unlikely at this point. Dr. Peter Khoury: 26:10 Right? And even if it disappeared, there’s always the chance of it coming back. The same with SARS , the same with MERS. I mean, all of those could somehow reappear. James Di Virgilio: 26:23 So we need to get a vaccine. We know that it takes a long time to actually manufacture a vaccine because it’s not that simple. It’s not like we have all the supply available in the world to produce a vaccine. We can’t just in a day, produce enough to give to the whole world. Right. So even when we get it right, it takes a while to actually produce enough to give out to all the people that need these vaccines. Here we are in the US in a country that has all of these resources. What if we’re not in the U S what if we’re in a developing country? What does it look like for them? Dr. Peter Khoury: 26:49 Yeah. So in the US yeah, we’re fortunate. We have a lot of vaccine manufacturers, large manufacturers here, and in the time of pandemic borders closed down. And so if you don’t have vaccine manufacturing on your soil, it can be a real issue. That’s times where the, WHO, UNICEF the large manufacturers get together and say, we need to do something for the developing world. And they actually will donate vaccines that are used in those areas. I know of some manufacturing processes, and we actually in our building bring in some of these new types of manufacturing, just on a trial basis. And some of them are small enough that they literally could be put in a shipping container and take into areas where vaccine needs to be produced immediately. But then you run into problems with clean water and power and other things. But someone has taken the first step to develop a concept of manufacturing that now whether you can get a turn on solar power and you ship in water, where that, or you make the manufacturing process somehow different, I think eventually they’ll have something that is a vaccine in a box that you could ship to these countries that will produce low cost vaccine very quickly. The smartest thing right now is to stockpile vaccine. If you can, if you’re a country and you have the wealth to do it, and you don’t have vaccine manufacturing, if there’s a chance for like the release of smallpox , for something as a bio threat, you may want to stock pile some of that vaccine, because if it ever happened, you’re going to wish you had. James Di Virgilio: 28:44 Right. I have something there. So herd immunity is talked about a lot, right? I’ve seen that we need maybe 50 to 60% of the population to have herd immunity. And it seems like there’s a lot of misconceptions starting with the UK, which that was their original strategy. Then they kind of shifted away from it. Now, maybe going to go back to selective release, to build herd immunity, assuming that this goes more of the route of HIV for a little bit, it takes longer than 18 months to get a vaccine, or are we able to build herd immunity without a vaccine? Or is this something where we would just continually have recurring outbreaks of the same significant level year after year? Dr. Peter Khoury: 29:21 It depends on what the virus does. If the virus goes away, you’ll never develop herd immunity. Just the people that happened to come down with it . The same with SARS. I’m curious if someone had SARS, are they immune to this Corona virus? That’d be interesting. I’m sure someone’s looked at it because there may be some cross reactivity, the two, but eventually enough people would be infected and recovered that you’d reach that 50 or 60% mark. And then it’s again, a game of numbers where the virus no longer is transmitted rampantly through the population. And so exposure risk goes down dramatically. When you reach that. The other approach, when you do have vaccines or monoclonal antibodies, is you do ring vaccination, where you find an area where people are infected and around it, you vaccinate everyone in the area. And so it’s contained. And that actually has been shown to work very, very well. Now, if in Wu Han, they had identified and raise their hand very early and put something in place where they either stop the movement of people within that area, which is probably all they could do. Then it probably could have been restricted much, much more, or if there was a vaccine available, vaccinating everyone around the city and making sure people didn’t move out until they were over it. James Di Virgilio: 30:49 Right. And that’s the key is stopping the transmission. If we have five people that are immune, got a vaccine there, then all of a sudden you have the one sick person, the virus can’t get passed on, which is obviously the goal. So let’s spend just a few minutes talking about something that maybe is been confused or is confusing. Are we flattening the curve, therefore reducing the total number of people that will get this, or are we just shifting the total number of people to get this to a lower monthly average? So basically same total are going to get it regardless, but we’re just spreading it out. Dr. Peter Khoury: 31:19 See we never know again, because we don’t know if the virus will just dissipate and disappear. If it doesn’t then as you lower the curve, you’re maybe spreading it out. But when you spread it out like that, the vaccine comes out a year and a half later, then there’s a lot of people that still can be vaccinated that haven’t had it. And so there’s a much lower risk that they’re going to get it and then die, or have significant morbidity in mortality from the actual disease itself. So flattening the curve helps in two ways. One is if the virus stops circulating, more people were suffered the consequences of having the disease. The other is if it continues to circulate, you’re buying yourself time to get something that could, in a sense, truncate people getting sick, which would be the vaccine in this case, James Di Virgilio: 32:14 Is there a consideration to extreme flattening of the curve, which we know will potentially lead to more people, not getting it in the short term, but with the other side, which is how much damage do you do to society. And there seems to be two effects. We have Spanish influenza where most cities did nothing, and they took the full brunt of that peak, heavy hits, 50 million die. And then you have what we’re doing now, which is the first world’s response to really do exactly what you just said. Is there a balance and consideration as a medical person, do you think of what do we do over here economically, if everyone loses their job for a year, or is there just, this is the way we have to do it in order to reduce these cases? Dr. Peter Khoury: 32:51 That’s a real difficult one because as I look around me and I see the unemployment rates skyrocket 10%, 10% last night, I was listening to the news and I just couldn’t believe that it’s gone up so much and that’s just in the US let alone other countries. And I think it’s going to definitely cause a global bump, how quickly we recover from that. I think we’re pretty wrestling and the whole world will recover, but all of the ships are going down at the same time. So the question is, how much impact does it really have on the economy? If the whole globe is shrinking, if everyone’s economies being hit by the same thing. And that’s the part I don’t understand is it could be a lot worse if it were just the US and everyone else was still thriving. That probably would be even worse for us. But when everyone’s going through the same hurt, it’s still bad. There’s no doubt about it because production’s down. People just don’t feel like they’re productive, which is also a mindset thing. It’s, it’s not good for anyone. That’s a real tough question to ask, but there is a trade off there. There’s no doubt about it. And if there were a way to protect everyone and they could go to work, and we knew that they stopped shaking hands and everyone stayed exactly six feet away from each other, eventually the virus would go away. James Di Virgilio: 34:20 And I think that’s, what’s interesting is we tend to look at these things in static environments, but the reality is every day we’re learning more. And , and even though we know that maybe there could be, like you said, a rebound in the fall, everything we’re learning every day helps to apply how we might return to normalcy. And I think one thing I’ve really learned is that we respond very well as humans. We’re not good predictors. We’re excellent responders. We’re very creative. We’re great problem solvers, but we have to have the problem in front of us, which we now have. And like you mentioned, I think the doomsday scenarios of us flattening the curve and no one doing anything for months is probably unrealistic because there will be some tactical solutions to get people back. Bill Gates, himself, I saw just said, I think a day or two ago that the global economic reaction to this will not be immediate recovery. This will take time, which I think he’s totally correct. And there’s also something else that I think has gotten lost in this, whether the government should have reacted faster or slower or whatever the case may be. Some things in life are beyond our grasp to understand right away, could China to something earlier. Absolutely, will that hopefully be a model for the world later? Yes, but we don’t have a clear solution forward. Like you mentioned, we hope that we’re thinking of the trade offs. If I choose this course of action, hopefully I won’t bankrupt the whole world, but if I don’t choose that course of action, how many more people get it right now? Can we handle every, all these questions? They’re very difficult to answer. And so I think day by day is the course to say, what’s the new data say, what are we doing? And ultimately, when it comes to a vaccination, is it helpful to have more testing at all? Or do we already have all that we need on the vaccination front to get all that research done? Testing is irrelevant to actually developing a vaccine. Dr. Peter Khoury: 35:51 I think testing is very important. There’s no doubt about it, but how much of it can be done concomitantly with administering it to people that are at high risk, let’s say so that’s when you get into that whole risk benefit again. So the very first people in the phase one and two, should they be the emergency room workers cause you now, Hey, if it works, that’s great for them. If it doesn’t work, maybe a few will have some issues, but there’s a chance that it’s going to work because some of these are pretty tried and true methods. It’s a real trade off. And it all comes down to that risk and benefit. People tend to like pointing their fingers at the FDA, but the FDA has a job of keeping people safe. And when you’re administering in our country, over 300 million doses of this, they give a vaccine to every person in the country. That’s a lot of people, that’s a lot of lives that you’re taking responsibility for, but there is an urgency to , so again, there it’s that whole risk benefit. James Di Virgilio: 36:55 Right? And I tend to be someone who thinks central governing organizations are slow and inefficient in general. Because again, it’s hard for us to prescriptively know what’s going on, but in times like these there’s things that I think are being done well, which the FDA has greatly relaxed the hurdles that exist to create a vaccine. So no matter how you feel about the FDA, if you’re more like me, the things I’d like to see it be a little more expedited in times it’s happening now. And in fact, I think it’s safe to say, if we just got rid of the FDA right now, it sounds like the vaccination time wouldn’t be any faster than 18 months at this point in time. Or if it was, it wouldn’t be significantly more, right ? So we can take that off the table. The FDA is not going to materially affect the speed with which we’re creating a vaccine for COVID-19, which is a good thing to get out there. All right . This has been a wonderful wide ranging expert discussion on vaccinations. Certainly we applaud Ology for doing something that’s brand new, which is really neat, right? This DNA vaccination. We look forward to hearing more about this as we go on to conclude the podcast. Is there anything that we haven’t talked about yet that you feel is something you’d like to discuss? Dr. Peter Khoury: 37:57 I feel like I’m the most fortunate CEO in the world. I lead a company that is still privately held and with a large majority of our shareholders that are current or past employees. So many of them are really dedicated individuals. It really see the value that we bring to the market, not just bottom line profits. It allows us to truly support programs where we can combine the measurement of profitability and potential life saved to what Gates foundation does when we decide I’m bringing in new work. So I mentioned that we do work with the government and we do a lot of commercial work with everything from small laboratories to large multinationals. But we also do work for NGLs is like the Gates foundation and others. That really is not all that profitable. And I know that these doses are going to developing world countries and whatever, but my team who, as I said, are everyone that joined their company is given options for shares. The first day they joined, because I believe that if they’re invested in the company, that they will always do the right thing, they’ll always raise their hand when there’s an issue. And they’ll make sure that we have the best quality and we’re the safest. And they’re the ones that agreed that they don’t mind taking a little less money if we’re helping to save lives in doing so. So I’m still proud of them in taking that mindset on it. It’s a lot of the younger, what I’d call millennials, the younger crowd that really likes that. And when we bring in new programs, we have to sit everyone down and explain to them exactly what it is and how it’s used and what the diseases and how many people died , because they want to understand exactly how they’re helping the world and God bless them for doing it. James Di Virgilio: 39:58 Yeah. Love your neighbor as yourself. Right. And there’s a lot of that going on now, there’s one silver lining to something like COVID-19, it does bring the world together and makes you recognize there’s really no such thing as race or gender difference or things like that. Because at the end of the day, we’re a human race and we’re all people and this virus doesn’t care. It doesn’t at all about the fact that you’re a different color from someone else that does care that you are human. And like you mentioned, we can care for our neighbors. We can care for those that have less resources than we have. And we should use that if we have the ability to assist. And the culture at your company obviously is doing that from day one, which will I’m sure leads you to better results in the long run. Anyway. Dr. Peter Khoury: 40:34 It, will I’m sure. Thank you. James Di Virgilio: 40:36 Dr. Peter Khoury. Thank you so much for joining us. This has been absolutely fantastic. We’ve certainly enjoyed visiting with you and for Radio Cade. I’m James Di Virgilio. Outro: 40:45 Radio Cade is produced by the Cade Museum for Creativity and Invention located in Gainesville, Florida. This podcast episodes host was James Di Virgilio and Ellie Thom coordinates, inventor interviews, podcasts are recorded at Heartwood Soundstage, and edited and mixed by Bob McPeak. The Radio Cade theme song was produced and performed by Tracy Collins and features violinist, Jacob Lawson.

Bienvenidos a PADRES el podcast para papás y mamás primerizos, estresados y en apuros. Hoy vamos a dedicar el programa a todos aquellos padres que se estresan al salir de casa con los niños. Especialmente cuando quedan diez minutos para que pase el autobús del colegio y empiezan a sacar cacharros. En ese corto período de tiempo, son capaces de destrozarte la casa entera, de ponerlo todo patas arriba y en ese momento te tienes que plantar. Tienes que decidir si sales por la puerta, cierras y te olvidas de todo o te paras a recoger, te enfadas y terminas perdiendo el bus. Nosotros optamos por la primera porque mañana vuelve a amanecer. Habrás notado además, que antes, salías el tiempo para prepararte y salir de casa era de aproximadamente 30 minutos. Ahora, con los niños, no baja de hora y media. Cuánto gasta un bebé el primer año En el programa de hoy, vamos a hablar de una duda que nos surge a todos los padres cuando vas a ser padre ¿Cuánto gasta un bebé el primer año? Pues bien, lo hemos ido contabilizando y aquí te traemos el desglose: - Carrito y sillita del coche | Nosotros nos hemos enamorado del Bugaboo en color arena (edición especial) y en cuanto a la silla del coche, nos decidimos por la Cybex Sirona. Porque somos unos fieles defensores de "ACM" (A Contra Marcha) y por los numerosos estudios, análisis y comparativas que existen en el mercado. En la gran mayoría, la ponen como una de las mejores sillas que se comercializan hoy en día - Ropa de bebé directamente se la compramos a Capotinas, como no podía ser de otro modo ¿no? - Aseo | Nunca fuimos de toallitas y cremas, aún así los pañales Dodot no se los quita nadie - Mobiliario | Siempre nos quedará IKEA y láminas infantiles para bebé - Vacunas | Depende de la comunidad autónoma donde vivas, tendrás las vacunas subvencionadas por la seguridad social o no. En nuestro caso, Rotavirus y Bexsero no entraban - Guardería | Si tienes la suerte de que papi o mami puedan cuidar de los pequeños, o incluso los abuelos, te ahorrarás mucho dinero a final de mes. En otro caso, no queda otra que llevarlos a la guardería Al final, la friolera sale: - Con guardería: 6.823€ / 568€ al mes - Sin guardería: 4.106€ / 342€ al mes Por tanto, todos aquellos caprichos que querías comprarte, ya puedes ir posponiéndolos (o comprándolos ¡ya! jajajaja) Todos vuestros comentarios y feedbacks los comentaremos en el siguiente capítulo. No olvidéis suscribiros al podcast y valorarnos con 5 estrellas en iTunes, en iVoox y porfa please darle al corazoncito en Spotify, dejar vuestros comentarios, preguntarnos lo que queráis y sobre todo ¡Sed felices! --- Send in a voice message: https://anchor.fm/padres/message

Originally aired July 9, 2014: Statins for COPD, ARDS and human-bovine Rotavirus vaccine Fahad and Amol want you to: 1. Understand that 2 high quality RCTs demonstrate that statins are not effective in improving clinical outcomes in either COPD or Acute Respiratory Distress Syndrome (ARDS). 2. Recognize that a novel Rotavirus vaccine was developed through an international public-private ... The post Sorry Sports Analogies: Statins in ARDS and COPD, Rotavirus Vaccine appeared first on Healthy Debate.

This week: Statins for COPD, ARDS and human-bovine Rotavirus vaccine Fahad and Amol want you to: 1. Understand that 2 high quality RCTs demonstrate that statins are not effective in improving clinical outcomes in either COPD or Acute Respiratory Distress Syndrome (ARDS). 2. Recognize that a novel Rotavirus vaccine was developed through an international public-private partnership that is ... The post Sorry Sports Analogies: Statins in ARDS and COPD, Rotavirus Vaccine appeared first on Healthy Debate.