Podcasts about l dopa

Mit welchen Nootropica holt man sich Extra-Antrieb, wenn's zählt? Eine Folge über Dopamin-Abbauhemmer, stotterstartende Oldtimer und Stefans neuen liebsten Morgenstack: Uridin plus Kaffee plus Rhodiola Rosea, außerdem besorgt er sich Citicolin. Zum angesprochenen Event am Krallerhof (inklusive Käsebuffet) geht es hier.   Methylenblau in Pharmaqualität gibt es hier.   Den Dopamin-Vorläufer L-Tyrosin gibt es hier. L-Dopa ist in Deutschland und Österreich verschreibungspflichtig. Eine natürliche Quelle von L-Dopa ist Mucuna pruriens (Juckbohne), ein entsprechendes Extrakt gibt es hier. Piracetam gibt es (nur auf Rezept) zum Beispiel hier. Modafinil gibt es (nur auf Rezept) zum Beispiel hier. Eine gute Quelle für Rhodiola Rosea ist diese hier. Hochwertiges Ashwagandha gibt es hier. Uridin Monophosphat gibt es hier. CDP Cholin aka Citicolin gibt es hier.   Kreatin gehört zur Biohacking-Grundausstattung. Ein gutes Produkt ist zum Beispiel dieses. L-Carnitin kann, wenn es in größeren Mengen und regelmäßig supplementiert wird, Schäden am Mikrobiom des Darms verursachen, Allicin kann diese Schäden theoretisch abwenden. (Das Ganze hat mit TMA und TMAO zu tun.) Es gibt dazu noch keine ernsthaften klinischen Studien. Man kann es mit Allicin also mal versuchen, und mit Carnitin nicht übertreiben. Carnitin gibt es hier. Und Allicin gibt es hier.    Zu Olga Winklers Re-Gen in Salzburg geht es hier.   Zum Glücksaffen geht es hier. 

Über 400 000 Menschen sind in Deutschland von Morbus Parkinson betroffen; Tendenz seit Jahren um fast 20% steigend. Die Ursachen sind vielfältig: Umwelt, Darm und Nervensystem. Bei den Landwirten in Frankreich ist es als Berufskrankheit bereits anerkannt. Pestizide und Herbizide zerstören leider nicht nur das Nervensystem von Insekten. Die Folgen sind schwerwiegend. Das zunächst der Lebensstil angepasst werden sollte, versteht sich von selbst. Jedoch gibt es mittlerweile Alternativen von den weit verbreiteten Mitteln wie L-Dopa. Birkenblätter wirken ähnlich wie L-Dopa. Warum also nicht über den Tellerrand hinausblicken und die Natur als Heilmittel nutzen. Bei Fragen schreiben Sie mir gerne an gesund@juttasuffner.de https://mentoren-verlag.de/werke/gesund-sterben-das-ist-moeglich-das-buch/ Das Hörbuch "Gesund sterben" gibt es z. B. bei Spotify: https://open.spotify.com/intl-de/album/7KLQDQBdUS9aTFPB9EL8LB?si=MmcqRgoiTdKWg_CUYEfWcw

Retrouvez Rudy Coia et June pour animer le SuperPhysique Podcast réservés aux pratiquants naturels de musculation. QUI EST RUDY COIA ? Rudy est auteur, coach et formateur. Il intervient aussi bien auprès des particuliers, des athlètes que des futurs coach sportif. Passionné de sport, il partage ses connaissances depuis 2001 notamment via des articles, vidéos et podcasts. QUI EST JUNE ? June est coach sportive depuis 2018. Elle a commencé par enseigner et pratiquer le Crossfit, sa première passion, avant de se tourner vers le Bodybuilding naturel dans lequel elle a participé à 2 compétitions en 2022. Elle est particulièrement active sur Instagram sur son compte @junecoach74 et anime le podcast "Beyond Your Why". ---- FORMATION GRATUITE POUR PRATIQUANTS NATURELS - https://www.rudycoia.com/newsletter/ COACHING A DISTANCE AVEC RUDY - https://www.rudycoia.com/produit/suivi-coaching-a-distance/ June sur Instagram - https://www.instagram.com/junecoach74/?hl=fr MES LIVRES - https://www.rudycoia.com/boutique/ LA FORMATION SUPERPHYSIQUE - https://methodesp.rudycoia.com POUR RESERVER SON COACHING PREMIUM - https://www.rudycoia.com/produit/coaching-premium/ FORUMS SUPERPHYSIQUE - https://www.superphysique.org/forums/index.php MES COMPLEMENTS ALIMENTAIRES - https://www.superphysique.org/nutrition L'APPLICATION SP TRAINING - https://www.sp-training.fr/

In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss the neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://www.eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Mark D'Esposito (00:02:08) Sponsors: Maui Nui, Joovv & Eight Sleep (00:06:23) Brain & Frontal Lobes, Prefrontal Cortex, Executive Function (00:10:31) Frontal Lobe Development, Children (00:14:12) Rules, Context & Impulse Control; Learning & Goals (00:21:45) Focus, Improving Executive Function (00:26:04) Connections & Top-Down Signals (00:29:02) Sponsor: AG1 (00:30:29) Frontal Lobe Injury; Emotional Regulation (00:37:26) Smartphones, Social Media (00:44:37) Working Memory, Dopamine (00:52:59) Sponsor: LMNT (00:54:22) Dopamine Levels & Working Memory, Cognitive Tasks, Genetics (01:00:03) Bromocriptine & Working Memory, Dopamine (01:06:21) Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests (01:12:46) Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall (01:19:27) Concussion, Traumatic Brain Injury (TBI) (01:25:22) Sleep, TBI, Concussion & Executive Function; BrainHQ (01:31:57) Aging & Frontal Executive System; Brain Health (01:39:26) Tools: Brain Health & Boosting Executive Function, Books (01:47:26) Alzheimer's Disease, Genetics, Pharmacology (01:51:48) Parkinson's Disease, L-Dopa; Coping with Alzheimer's; Nicotine (01:58:37) Estrogen & Dopamine, Cognition; Tool: Physical Exercise (02:04:43) Tool: Mindfulness Meditation & Executive Function (02:10:31) Brain Networks; Modularity (02:17:08) Modularity, Brain Indices (02:22:53) Psilocybin; Transcranial Magnetic Stimulation (02:30:16) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer

The episode focuses on increasing dopamine, a neurotransmitter involved in focus, motivation, reward, pleasure, and happiness. Nurse Doza recommends taking vitamin B9, particularly the methylated form called 5MTHF, to support dopamine production. He explains that many people are deficient in B9 and warns against using the inferior form called folic acid. The host also mentions his personal experience with methylation difficulties and the importance of methylation for dopamine production.   TIMESTAMPS: 00:00 START 02:30 Increasing dopamine. 03:42 Vitamin B9 and dopamine production. 07:21 Vitamin B9 and focus. 11:17 Boost for natural energy. 15:28 Increasing healthy dopamine. 18:49 The role of SAMe in depression. 21:33 Increase dopamine for productivity. 25:12 Supporting the COMT Gene. 27:38 Supporting genetics and mental health.   --- Today's podcast episode is sponsored by BLISS, the newest tart lemon flavored sublingual supplement in the wellness market. Designed to give your serotonin and dopamine levels a healthy boost, BLISS not only supports your mood but also enhances your overall well-being. Just a quick drop under your tongue for 30 seconds, and you'll experience the difference. Click the link in our description to get your hands on BLISS.  https://www.mswnutrition.com/collections/best/products/bliss/?ref=baldo use CODE: NURSEDOZA for a discount --- Show Notes Today, we're sharing scientifically-backed tips to naturally enhance your dopamine levels. Get ready to take notes!  Tip 1: B9 Vitamin Intake^1,2^ Vitamin B9 plays a crucial role in the synthesis of serotonin and dopamine, the neurotransmitters that regulate mood^1^. It's associated with psychiatric symptoms, and its neuroprotective benefits are lost when patients lack a specific genetic enzyme, which converts folate/folic acid to its most usable form, L-methylfolate. This allows for the synthesis of the three major neurochemicals-serotonin, nor-epinephrine, and dopamine-across the blood-brain barrier^2^.  Studies:  1. [Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/)  2. [Vitamin B Supplementation: What's the Right Choice for Your Patients?](https://pubmed.ncbi.nlm.nih.gov/28671236/) Tip 2: Vitamin B6 Intake^1,2^ Vitamin B6-dependent enzyme in the brain, the aromatic L-amino acid decarboxylase, catalyzes the synthesis of dopamine from phenylalanine^1^. Evidence suggests that B6 undernutrition can lead to a loss of dopamine in the brain^2^. Studies: 1. [Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/) 2. [Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum](https://pubmed.ncbi.nlm.nih.gov/2761676/) Tip 3: Take SAMe^1,2,3,4^ SAMe is an endogenous amino acid metabolite and enzyme co-substrate involved in multiple biochemical pathways, including biosynthesis of hormones and neurotransmitters. Studies suggest that SAMe may increase the dopaminergic tone in the brain^2,3,4^. Studies: 1. [THE ADRENAL GLANDS PART I: THE ADRENAL MEDULLA](https://www.sciencedirect.com/science/article/abs/pii/B9780702033728000057) 2. [S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501081/) 3. [Oral S-adenosylmethionine (SAM) Administration Increases Whole Brain Concentrations of Dopamine and Norepinephrine in Rats](https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.29.1_supplement.134.3) 4. [Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant](https://pubmed.ncbi.nlm.nih.gov/2120432/) Tip 4: Copper Intake^1^ Dietary copper deficiency is associated with a reduction in dopamine^1^.  Studies:  1. [Copper: from neurotransmission to neuroproteostasis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080678/) Tip 5: Support the COMT Gene - Quercetin^1,2,3,4,5,6,7^ The catechol-O-methyltransferase (COMT) gene, involved in dopamine metabolism, and the MTHFR gene, affecting COMT methylation and function, are critical in maintaining dopamine levels. Quercetin, through its COMT-inhibiting properties, might potentiate dopamine effects^6^. Studies:  1. [Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742018/) 2. [Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice](https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1471-4159.2010.06889.x) 3. [Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment](https://pubmed.ncbi.nlm.nih.gov/22483291/) 4. [Tyrosine Hydroxylase and Regulation of Dopamine Synthesis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065393/) 5. [A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351536/) 6. [Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition](https://pubmed.ncbi.nlm.nih.gov/12711835/) 7. [Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590855/) --- Before we sign off, don't forget about our sponsor BLISS. Just drop under the tongue and you're paving the way to healthier levels of serotonin and dopamine. This tart lemon sublingual supplement is a game-changer, bringing a blissful transformation to your day-to-day life. Don't miss out on this wellness opportunity! Click the link in our description to purchase BLISS now. Remember, a healthier, happier you is just a drop away! https://www.mswnutrition.com/collections/best/products/bliss/?ref=bliss ---

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551112v1?rss=1 Authors: Flores, A. J., Bartlett, M. J., Seaton, B. T., Samtani, G., Sexauer, M. R., Weintraub, N. C., Siegenthaler, J. R., Lu, D., Heien, M. L., Porreca, F., Sherman, S. J., Falk, T. Abstract: Levels of the opioid peptide dynorphin, an endogenous ligand selective for kappa-opioid receptors (KORs), its mRNA and pro-peptide precursors are differentially dysregulated in Parkinson disease (PD) and following the development of L-DOPA-induced dyskinesia (LID). It remains unclear, whether these alterations contribute to the pathophysiological mechanisms underlying PD motor impairment and the subsequent development of LID, or whether they are part of compensatory mechanisms. We sought to investigate nor-BNI, a KOR antagonist, 1) in the dopamine (DA)-depleted PD state, 2) during the development phase of LID, and 3) with measuring tonic levels of striatal DA. Nor-BNI (3 mg/kg; s.c.) did not lead to functional restoration in the DA-depleted state, but a change in the dose-dependent development of abnormal voluntary movements (AIMs) in response to escalating doses of L-DOPA in a rat PD model with a moderate striatal 6-hydroxydopamine (6-OHDA)lesion. We tested five escalating doses of L-DOPA (6, 12, 24, 48, 72 mg/kg; i.p.), and nor-BNI increased the development of AIMs at the lower doses (12 and 24 mg/kg L-DOPA). However, after dosing with 72 mg/kg L-DOPA, AIMs were not significantly different between control and nor-BNI groups. In summary, while blocking KORs significantly increased the rate of development of LID induced by chronic, escalating doses of L-DOPA in a moderate-lesioned rat PD model, it did not contribute further once the overall severity of LID was established. While we saw an increase of tonic DA levels in the moderately lesioned dorsolateral striatum, there was no tonic DA change following administration of nor-BNI. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.26.550763v1?rss=1 Authors: Abe, Y., Yagishita, S., Sano, H., Sugiura, Y., Dantsuji, M., Suzuki, T., Mochizuki, A., Yoshimaru, D., Hata, J., Matsumoto, M., Taira, S., Takeuchi, H., Okano, H., Ohno, N., Suematsu, M., Inoue, T., Nambu, A., Watanabe, M., Tanaka, K. F. F. Abstract: Dyskinesia is involuntary movement caused by long-term medication with dopamine-related agents: the dopamine agonist, L-DOPA, to treat Parkinson disease (L-DOPA-induced dyskinesia [LID]) or dopamine antagonists to treat schizophrenia (tardive dyskinesia [TD]). However, it remains unknown why distinct types of medications for distinct neuropsychiatric disorders induce similar involuntary movements. Here, we searched for a shared structural footprint using magnetic resonance imaging-based macroscopic screening and super-resolution microscopy-based microscopic identification. We identified the enlarged axon terminals of striatal medium spiny neurons in both LID and TD model mice. The striatal overexpression of vesicular gamma-aminobutyric acid transporter (VGAT) was necessary and sufficient for modeling these structural changes; VGAT levels gated the functional and behavioral alterations in dyskinesia models. Our findings indicate that lowered type 2 dopamine receptor signaling with repetitive dopamine fluctuations is a common cause of VGAT overexpression and late-onset dyskinesia formation, and that reducing dopamine fluctuation rescues dyskinesia pathology via VGAT downregulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Christian Hageseth is an 82-year-old retired psychiatrist. His first symptoms of PD started 18 years ago, yet he only started taking L-Dopa 2 ½ years ago. He credits his success in slowing PD—almost to a halt—to his attitude, exercise, and practicing yoga. He directed his local PD support group from 2012 to 2019. During that time, the numbers of attendees went from thirteen to more than one hundred every month.  Today he feels it is critically important for PWPs to avoid spending their time looking for for the next new drug to show up. Instead, he says to live life to its fullest. He reminds us that PD does not appreciably shorten the life span of PWPs. And he also reminds us that medications such as L-dopa do not increase longevity. He has always viewed PD as a challenge, not a curse. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.26.538384v1?rss=1 Authors: Sano, H., Nambu, A. Abstract: Zonisamide (ZNS; 1,2-benzisoxazole-3-methanesulfonamide) was initially developed and is commonly used as an anticonvulsant drug. However, it has also shown beneficial effects on Parkinson's disease (PD), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain. Recent clinical studies have suggested that ZNS can also have beneficial effects on L-DOPA-induced dyskinesia (LID), which is a major side effects of long-term L-DOPA treatments for PD. In the present study, we examined the behavioral effects of ZNS on LID in PD model mice. Acute ZNS treatment did not have any observable behavioral effects on LID. Contrastingly, chronic ZNS treatment with L-DOPA delayed the peak of LID and reduced the severity of LID before the peak, but increased the duration of LID in a dose-dependent manner of ZNS, compared to PD model mice treated with L-DOPA alone. Thus, ZNS appears to have both beneficial and adverse effects on LID. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.12.516261v1?rss=1 Authors: Andres, E., Chuan-Peng, H., Gerlicher, A. M. V., Meyer, B., Tuescher, O., Kalisch, R. Abstract: Even after successful extinction, conditioned fear can return. Strengthening the consolidation of the fear-inhibitory safety memory formed during extinction is one way to counteract return of fear. In this preregistered direct replication study, we confirm that spontaneous post-extinction reactivations of a neural activation pattern evoked in the ventromedial prefrontal cortex (vmPFC) during extinction predict extinction memory retrieval 24 h later. We do not confirm that L-DOPA administration after extinction enhances retrieval and that this is mediated by enhancement of the number of vmPFC reactivations. However, additional preregistered analyses reveal a beneficial effect of L-DOPA on extinction retrieval when controlling for salivary alpha-amylase (sAA) levels, an indicator of arousal, at extinction onset. Further, pre-extinction sAA negatively predicts retrieval and (at trend) vmPFC reactivations, and these impeding effects are abolished by L-DOPA treatment. Our results suggest that L-DOPA may enhance extinction consolidation under high-arousal conditions, as typically present during exposure therapy sessions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.29.509499v1?rss=1 Authors: Chakroun, K., Wiehler, A., Wagner, B., Mathar, D., Ganzer, F., vanEimeren, T., Sommer, T., Peters, J. Abstract: Dopamine fundamentally contributes to reinforcement learning by encoding predictions errors, deviations of an outcome from expectation. Prediction error coding in dopaminergic regions in human functional neuroimaging studies is well replicated. In contrast, replications of behavioral and neural effects of pharmacological modulations of the dopamine system in human reinforcement learning are scarce. Additionally, dopamine contributes to action selection, but direct evidence and process-specific accounts in human reinforcement learning are lacking. Here we examined dopaminergic mechanisms underlying human reinforcement learning in a within-subjects pharmacological approach in male human volunteers (n=31, within-subjects design; Placebo, 150mg L-dopa, 2mg Haloperidol) in combination with functional magnetic resonance imaging and a stationary reinforcement learning task. We had two aims. First, we aimed to replicate previously reported beneficial effects of L-dopa vs. Haloperidol on reinforcement learning from gains. This replication was not successful. We observed no performance benefit of L-Dopa vs. Haloperidol, and no evidence for alterations in neural prediction error signaling. In contrast, Bayesian analyses provided moderate evidence in favor of the null hypothesis. This unsuccessful replication is likely at least partly due to a number of differences in experimental design. Second, using combined reinforcement learning drift diffusion models, we tested the recent proposal that dopamine contributes to action selection by regulating decision thresholds. Model comparison revealed that the data were best accounted for by a reinforcement learning drift diffusion model with separate learning rates for positive and negative prediction errors. The model accounted for both reductions in RTs and increases in accuracy over the course of learning. The only parameter showing robust drug effects was the boundary separation parameter, which revealed reduced decision thresholds under both L-Dopa and Haloperidol, compared to Placebo, and the degree of threshold reduction accounted for individual differences in RTs between conditions. Results are in line with the idea that striatal dopamine regulates decision thresholds during action selection, and that lower dosages of D2 receptor antagonists increase striatal DA release via an inhibition of autoreceptor-mediated feedback mechanisms. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.23.505021v1?rss=1 Authors: Cui, J., Carey, J. S., Pera, R. A. R. Abstract: Parkinsons disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra region of the midbrain. Diagnostic criteria for PD require that at least two of three motor signs are observed: tremor, rigidity, and/or bradykinesia. The most common and effective treatment for PD is Levodopa (L-DOPA) which is readily converted to DA and has been the primary treatment since the 1960s. Dopamine agonists have also been developed but are less effective than L-DOPA. Although the lack of a model system to study PD has hampered efforts to identify treatments, diverse screening strategies have been proposed for identification of new pharmaceutical candidates. Here, we describe a pilot screen to identify candidate molecules from a bioactive compound library, that might increase formation, maintenance and/or survival of DA neurons in vitro. The screen used a previously characterized reporter construct consisting of the luciferase gene inserted downstream of the endogenous tyrosine hydroxylase (TH) gene and neurons differentiated from human pluripotent stem cells for 18 days. The reporter mimics expression of TH and includes a secreted luciferase whose activity can be measured non-invasively over multiple timepoints. Screening of the bioactive compound library resulted in the identification of a single molecule, SGC0946, that is an inhibitor of DOT1L (Disruptor Of Telomeric silencing 1-Like) which encodes a widely-conserved histone H3K79 methyltransferase that is able to both activate and repress gene transcription. Our results indicate that SGC0946 increased reporter luciferase activity with a single treatment at 8-hours post-plating being equivalent to continuous treatment. Moreover, data suggested that the total number of neurons differentiated in the assays was comparable from experiment to experiment under different SGC0946 treatments over time. In contrast, data suggested that the survival and/or maintenance of DA neurons might be specifically enhanced by SGC0946 treatment. These results confirm other reports that indicate inhibition of DOT1L may play an important role in maintenance and survival of neural progenitor cells (NPCs) and their lineage-specific differentiation. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Theresa Richard, SLP educates us on the best approach to evaluating the adult patient with swallowing difficulty, including the importance and challenges of obtaining high quality assessments, and recommendations for therapy. The CME experience for this Podcast is powered by CMEfy - click here to reflect and unlock credits & more: https://earnc.me/gY34n9 --- CHECK OUT OUR SPONSOR DI4MDs Protect your most valuable asset, the skill and ability to practice your medical specialty. Be prepared by establishing a specialty specific disability insurance policy from the experts at DI4MDs. Contact them today at www.Di4MDS.com or call 888-934-4637. --- SHOW NOTES In this episode of BackTable ENT, Dr. Ashley Agan, Dr. Gopi Shah, and Theresa Richard, a board-certified speech language specialist (SLP) in swallowing and swallowing disorders, about diagnosing and managing adult dysphagia. First, Richard speaks about starting Mobile Dysphagia Diagnostics, a company that provides mobile FEES studies, her experience with having a son with a swallowing disorder, and her recent career shift towards providing speech-language education for her colleagues. Then, she discusses the two primary swallowing imaging studies: the modified barium study (MBS) and fiberoptic endoscopic evaluation of swallowing (FEES). MBS, also known as video fluoroscopy, was traditionally the gold standard for swallowing imagery. It is the superior imaging technique for detecting esophageal issues and provides a better understanding of the oral phase of swallowing. Richard prefers to use FEES first because it provides a live picture of laryngeal and pharyngeal structures. It is useful in patients with secretion issues and post-head and neck cancer surgery patients. Mobile FEES is also an option, which involves an endoscope with recording capabilities and a laptop. Next, Richard discusses how to work up a patient with dysphagia. She starts with taking a thorough history and asks the patient about their dietary routine, and their medical and surgical history. Common medications that may cause dysphagia are muscle relaxants, L-DOPA, and medications that can cause dry mouth, such as scopolamine patches. Next, she discusses eating habits, with special considerations for cultural practices, age, and disability status. She notes that functional swallowing can look different for individual patients. Patients who repetitively aspirate may have recurrent pneumonia and require further evaluation. The first basic test she performs is watching her patients swallow 3 ounces of water. If they cannot swallow the three ounces, she moves to imaging studies. If they can swallow the three ounces, she escalates the test and starts to give the patients thicker liquids and different food types. Some patients with dysphagia may require special considerations, such as ICU patients, patients with nasogastric (NG) tubes, and head and neck cancer patients. Finally, Richard discusses how ENTs can help SLPs by providing a solid case history and being available for communication throughout the patient's therapy. She also discusses a new type of therapy, adult neuromuscular stimulation, but notes that the parameters may be dangerous and not FDA approved. --- RESOURCES “So You're Having Trouble Swallowing” by Theresa Richard https://theresarichard.com/so-youre-having-trouble-swallowing/ Theresa Richard Blog https://theresarichard.com/blog/ Swallow Your Pride Podcast https://podcast.theresarichard.com/

SPEAKER SENIOR: Roberto Cilia SPEAKER JUNIOR: Giulia Lazzeri

In his book, Awakenings, Dr. Oliver Sacks recounted the cases of his patients who had contracted sleeping sickness during the great epidemic just after World War I. They were frozen in time until 1969 when Sacks gave them the medication L-DOPA and the patients “awakened”. The book, and the movie based on the book, explore questions of health, disease, suffering, care and human connection. What might our own awakenings be?

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: The best exercise for your lagging body part is the one you're NOT doing for it. (4:21) With Magic Spoon, you get what you pay for. (12:40) Fun Facts with Justin: African clawed frogs and regenerating limbs. (21:39) Is fasting coming back into favor? (23:56) L-Dopa supplementation for improved erections in men. (28:00) Whoopi Goldberg and how cancel culture is eating itself now. (31:57) Did you know Ned has a subscription service? (35:55) #ListenerLive question #1 - Are bodyweight-only programs as effective as ones with equipment? (39:42) #ListenerLive question #2 - What can I do if my body not changing on a low-calorie diet after coming off a bulk? (48:04) #ListenerLive question #3 - How can I incorporate resistance training to gain explosive strength for boxing? (1:03:56) #ListenerLive question #4 - How can I improve my athleticism in the gym? (1:14:23) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com February Promotion: MAPS Performance and MAPS Aesthetic 50% off!! **Promo code “FEB50” at checkout** Mind Pump #1745: How To Pack On Muscle To Your Lagging/Stubborn Body Parts Visit Magic Spoon for an exclusive offer for Mind Pump listeners! Lab Frogs Regrow Limbs, Opening Door for Regeneration Studies Drug mimics beneficial effects of fasting in mice Valter Longo - ProLon® Fast Eating Fat, Lifting Cows, and Preventing Seizures — An Intro to the Ketogenic Diet (with Dom D'Agostino) L-DOPA Supplement — Health Benefits, Dosage, Side Effects Whoopi Goldberg suspended from 'The View' Commanders is new name for Washington Football Team Visit NED for an exclusive offer for Mind Pump listeners! Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code “MINDPUMP” at checkout** Fit Mom Bundle | MAPS Fitness Products MAPS Fitness Anywhere Mind Pump #1565: Why Women Should Bulk MAPS Fitness Anabolic MAPS Powerlift The Key to Fitness Success is Self-Love – Mind Pump Blog Mind Pump #463: Olympic Medalist Tony Jeffries & Kevan Watson Of Box ‘N Burn Mind Pump #1437: The Unfiltered Truth About MMA With Phil Daru MAPS Prime Pro Webinar MAPS Prime Webinar Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Tony Jeffries (@tony_jeffries)  Instagram Phil Daru (@darustrong)  Instagram

Když se řekne DOPAMIN, co se Vám vybaví? Mně osobně motivace, úsilí, potěšení, ale i závislost a vyhoření. Dopamin je jeden velký parťák našeho mozku a nikdy bychom se bez něj nedostali tam, kde stojíme dnes. Donutí Vás zvednout zadek každé ráno z postele a jít usilovat o všechno to důležité v životě. Ve dnešním dílu rozebíráme důležité pilíře fungování dopaminu. Co je to vrstvení dopaminu a proč bychom s ním měli pracovat? Závisí potěšení na naší historii? Fungují Dopaminové Detoxy? Jaký je rozdíl mezi motivací a úzkostí? To vše a ještě mnohem víc se dozvíte ve dnešním dílu o dopaminu! Přejeme příjemný poslech. Navázali jsme spolupráci se SENS - Cvrččí protein je udržitelný a šetrný pro planetu. Je podobně kvalitní jako ten hovězí, ale využívá 2000x méně vody, 15x méně půdy a 12x méně krmiva a k tomu vyprodukuje 100x méně skleníkových plynů. se SENS máme skvělou zkušenost a dělají chutný tyčinky, cvrččí mouku a protein. S kódem BWA na damesene.cz máš SLEVU 15% Podporuj nás na PICKEY ( https://www.pickey.cz/brainweare ) a dostaneš Podcast o den dřív a každý RED PILL o týden dřív než všichni ostatní a bez reklam + spoustu dalších výhod! Zadej kód "BWA" pro slevu 10% na eshopu uplife.cz a herbal-store.cz Sledujte Brain We Are na sociálních sítích: Instagram ( www.instagram.com/brain_we_are ) nebo Facebook Podpořte nás jednorázově nebo na startovači Minutáž: 01:00 Matté, Kofein, Žvýkačky a Dopamin 04:00 Dopamin: Co dělá? 10:00 1. Mýtus dopaminu 17:00 Je Dopaminový detox bullshit? 22:00 Rozdíl mezi motivací a úzkostí 23:30 Mentální úroveň a Dopamin 26:00 Baterka pro potěšení – Každé potěšení je vykoupeno bolestí 32:00 Temná stránka vrstvení dopaminu 37:00 Maximalizace potěšení a Neuspokojitelná neuspokojitelnost 40:00 Jak Čokoláda, Sex, Nikotin a další podněty zvyšují dopamin? 47:00 Dlouhodobá optimalizace dopaminu a růstový mindset 50:00 Děti, malování, radost a odměna 54:30 Typy motivace 63:00 Reciproční uzavírání a závislost 74:30 Experimenty 85:00 Tipy a Návyky 92:30 L-DOPA

Movie: Awakenings (1990) Beers: Elysian Night Owl Pumpkin Ale (WA) & Ayinger Bairisch Pills (Germany) Crack a beer and enjoy this episode of Boozed Reviewz as CJ and Tyler slam some L- Dopa down their throats and have a little awakening. Talking 1990's “Awakenings”. Tasting Notes: Inflamed in the Membrane, Yummy in your tummy, Men's Room, Ankle Bone, Randy Newman, Sexual Awakening, Remember! You don't have to drink beer, but it would be a lot better if you did.  New Episodes every Wed! Don't forget to FOLLOW, RATE, AND REVIEW! Follow them on Instagram @boozedreviewz! Support them on Patreon: patreon.com/boozedreviewz Buy Merch: https://my-store-11718456.creator-spring.com/ ALL LINKS https://linktr.ee/boozedreviewz

We're bringing you a special edition on the podcast today, as Mason steps out of the interviewer seat and is interviewed by Tommy Moore on the Mind Body Plants Podcast. If you've ever wanted to listen to Mason go through the entire SuperFeast apothecary in both poetic and articulate detail; What's in the mindfully curated blends, the Organ systems they nourish, how the herbs are sourced, the seasons they best connect to, and the stories behind the formulations, this episode covers it all.   Tommy asks some great questions, and Mason dives deep into the world of Daoist tonic herbalism, discussing the lineage and how these heavenly messengers oscillate through Mind/Body/Spirit to bring healing and longevity. Mason opens up about his decade-long journey with SuperFeast, from grassroots beginnings to the epic company it is has grown into; Still maintaining the same core intentions of supporting people in maintaining wellness and longevity through tonic herbs and medicinal mushrooms. In comparing the western medical system with classical Chinese medicine, this conversation goes many places. Mason lays down what you need to know about Jing herbs, cultivating Qi, Nootropics, Brain health, Di Dao sourcing, and living in harmony with yourself and nature. This episode is the reminder we all need to stand empowered in our sovereign health.   "In classical Chinese medicine what you're looking at is the capacity for Qi to transform through a particular Organ system. And so you're looking at supporting that baseline regulatory capacity for inner transformation at all times; The ability for your body to accept and enable change to constantly occur. And you can see how different that clinical approach is going to be. You can see why Western medicine likes to just go, 'Yep, do that, bang. And now we're fixed'. Whereas if you take responsibility for helping someone move through changes in their body and in their life, that's a massive responsibility, and it's harder to be effective. It takes more keeping your finger literally on the pulse. Our medical and wellness system doesn't focus on or value that right now. It seems boring to focus on that constant capacity of 'this too will change'... Why? Because then you can't be right, and you can't dominate".   -Mason Taylor     Tommy and Mase discuss: Mycology.  Tonic herbalism.  The Daoist lineage.  Yin/Yang cultivation.  The culture of SuperFeast. The nature of Adaptogens. The SuperFeast apothecary. Di Dao sourcing and preserving tradition. Superior herbs (lifestyle herbs) and dosage. Autoimmune conditions and medicinal mushrooms. Brain health and nootropic herbs for neuro-plasticity.  The journey of SuperFeast; 10 years on from grassroots.  Psychedelic mushrooms, micro-dosing and mental health.  Cultivating organ health, longevity, and wisdom through herbs. Western medical system and classical Chinese medical system. Mason's personal journey from a uni student starting SuperFeast.     MasonTaylor Mason Taylor is the founder of SuperFeast. Mason was first exposed to the ideas of potentiating the human experience through his mum Janesse (who was a big inspiration for founding SuperFeast and is still an inspiration to Mason and his team due to her ongoing resilience in the face of disability). After traveling South America for a year, Mason found himself struggling with his health - he was worn out, carried fungal infections, and was only 22. He realised that he had the power to take control of his health. Mason redirected his attention from his business degree and night work in a bar to begin what was to become more than a decade of health research, courses, education, and mentorship from some of the leaders in personal development, wellness, and tonic herbalism. Inspired by the own changes to his health and wellbeing through his journey (which also included Yoga teacher training and raw foodism!), he started SuperFeast in 2010. Initially offering a selection of superfoods, herbs, and supplements to support detox, immune function, and general wellbeing. Mason offered education programs around Australia, and it was on one of these trips that he met Tahnee, who is now his wife and CEO of SuperFeast. Mason also offered detox and health transformation retreats in the Byron hinterland (some of which Tahnee also worked on, teaching Yoga and workshops on Taoist healing practices, as well as offering Chi Nei Tsang treatments to participants). After falling in love with the Byron Shire, Mason moved SuperFeast from Sydney's Northern Beaches to Byron Bay in 2015. He lived on a majestic permaculture farm in the Byron hinterland, and after not too long, Tahnee joined him (and their daughter, Aiya was conceived). The rest is history - from a friend's rented garage to a warehouse in the Byron Industrial Estate to SuperFeast's current home in Mullumbimby's beautiful Food Hub, SuperFeast (and Mason) has thrived in the conscious community of the Northern Rivers. Mason continues to evolve his role at SuperFeast, in education, sourcing, training, and creating the formulas based on Taoist principles of tonic herbalism.   CLICK HERE TO LISTEN ON APPLE PODCAST    Resources: Mason Instagram SuperFeast Instagram   Q: How Can I Support The SuperFeast Podcast? A: Tell all your friends and family and share online! We'd also love it if you could subscribe and review this podcast on iTunes. Or  check us out on Stitcher :)! Plus  we're on Spotify!   Check Out The Transcript Here:   Tommy Moore: (00:00) Mason, first and foremost, welcome and thank you for joining me on this podcast. Been following your work for a little while now, and I'm certainly thrilled to be able to welcome you here and to have a chance to speak to you and get a bit of a deep dive into some adaptogenic herbs and mushrooms that I personally take on almost a daily basis. So, before we get into all of that, how do you describe what you do?   Mason: (00:28) Yeah, it's been definitely a mixed bag of what I've done in the wellness space. My company, SuperFeast is at this point, I guess what I'm most well-known for nearly, it's going to be 10 years in May that I've had that company and it has evolved somehow despite my flippancy and desire to not be shackled down by the responsibility of business, it's grown to be a very... Yeah, it's a really beautiful, healthy business. I still feel I'd still own completely. So, it's still very grassroots and just ensconced in what my original intentions back in the day were. Before I started the company, I was just in my last year at uni and just trying to find ways to just to have my body be a little less lethargic, and I was a little bit worried the way I saw it.   Mason: (01:22) It's like I worried about my trajectory and what I saw, how I was going to be at 80 years old or 90 years old, or even 60 years old. And that kind of spurred me on to, even though I was gung ho and I was jumping into the deep end of extremism of diet and detoxification and just becoming basically an extremist and a purist in the health space. Ultimately, my intention was a real long term sustainable one. And so, I had the juice to kind of go extreme back then, but because my intention is what, where SuperFeast is at still and what kind of the mission or the intent is behind it at the same, what I have for myself, which is to just find whether it's practises or capacity to continually change and evolve with at different times of life, psychologically and physically, and just to find the herb, so on and so forth, that's going to facilitate and support my deepest health intentions to come true.   Mason: (02:17) And so, that, for me, when I was in uni studying herbalism, I wanted to potentiate the body. And so, that meant I didn't go for things that were problem-solution kind of herbs. Western herbalism didn't really interest me back then because it was more clinical. You take it for this, take it for that. But Daoist herbalism, the ancient Chinese philosophy and path of the Dao, their herbs were... They had this whole dialogue about cultivating organ health and cultivating the body. And that just really made sense to me because I didn't want to have a problem solution and initial problem-solution approach to my health and life. And that's where SuperFeast is basically at. It's just this gentle, this we source medicinal mushrooms. And when a lot of people know adaptogens in a way that's based on the Daoist tradition.   Mason: (03:06) So, it's just make getting them as close to nature as possible and having them be as robust as possible, so that with the same intention that they've had for thousands of years all over the world using herbs for health, it's just to keep you that little bit healthy, go get you on the front foot that little bit more. When you get a little bit more juice in your body, and you're not having to worry about symptoms and degeneration, or even fatigue. Even though these things can still be there in variants, if it's just like a little bit less of that, if you're a little less immune compromised, you don't have to waste your energy or your Qi on surviving. Those symptoms, you can get on the front foot and develop yourself and ultimately, when you get a little bit older, you're not degenerating and hopefully, you've had the power to overcome developmental issues, psychological issues.   Mason: (03:51) So, you're a little bit less of an asshole and you're actually someone who's got some wisdom and someone who... It doesn't have to be so reliant on external stuff in order to stay healthy, and that's basically what SuperFeast is. Back in the day, I was like, "No, I just don't want to see any more degenerative disease in the world." And that's still a nice, lofty mission that probably won't ever come true because it's beautiful, it's relating to decay has been bad, but I really was mourning at the, seeing so much unnecessary degeneration and wasting away of the body and not living in harmony with yourself in nature. And so, I'm a really at a point at that SuperFeast, it's just like people have intentions around their health.   Mason: (04:38) I don't have an agenda about where that leads them, but through our education, because we have educational courses as well, and about living in harmony with nature and yourself, but then especially the herbs and the medicinal mushrooms that we saw. So specifically, they can really just help the organs flow, cultivate the organs, get the immune system nice and healthy so that there's a little bit less for people to worry about and they can go on, making their health intentions come true and becoming less of an asshole and more of their awesome selves.   Tommy Moore: (05:07) I love how you speak to the Daoist tradition because thousands and thousands of years ago, when we didn't have science, we didn't have all of this empirical evidence or clinical evidence about any of these herbal medicines or medicinal mushrooms, but that had practised this for so, so long, and they didn't necessarily need to know what a biochemical was because I guess back then, what they would call a spirit, we would now possibly call a biochemical. And so, I really, really loved this link between science and spirituality, especially when we're talking about mushrooms and herbs, that they can change how we feel. They can change how we act and our behaviour. They can make us feel more connected to each other. Now, this will be the first time that I've spoken about medicinal mushrooms and herbs. So, before we get deeper into science and philosophy, let's start with some basic definitions. What is meant by a herbal tonic? What is meant by a medicinal mushroom, and also what is meant by an adaptogen?   Mason: (06:19) Yeah, good order that you've put them in. So, tonic herbs is, that term is a rough translation over from about 2000 years ago, we get the first herbal materia medica, cataloguing herbs and their uses and categorising them. And, this is why I study a Daoist path because it's the ancient Chinese, the ancient health nuts, as I kind of refer to them. At times, they're the ones that documented it and came up with terminology, whereas right now, you don't see a [flowering 00:06:54] just yet of the Australian herbal tradition, because it was verbal. It was a bit more, I guess you'd say more spirit-based versus 3D-based, and that's in a lovely way. The Daoists documented specific, very physical practise-based health practises.   Mason: (07:15) And so, since it was written, it's like it's there on offer and able to be utilised, which is a little bit different to a verbal tradition, especially one that's been consciously wiped out and hopefully not forever. And there's beautiful people preserving that and slowly, we own the right to be able to partake in that once we get, how to do that with respect and not just to be treating it as a commodity, which is the worst thing that happens in the wellness scene, in the herbal scene as the things that are based in basically, as you said, spirit, so it shows and the science can be there, but that's doing something following a path in a way that it's complete. I guess holistic is the word that's a bit bastardised, but nonetheless, it's like, we partake in tonic herbalism and we reflect on it based on the entire system of Daoism and reflecting on where the civilization was at, not just take a scalpel, which is what Western herbalism and Western medicine does a lot of time.   Mason: (08:11) Just we'll just get a scalpel and just like... We'll take that and we'll leave the rest. And we'll talk a little bit more about that when we get to adaptogens, because that's not a bad thing, taking something out and going, this is an adaptogen used in these scenarios. As long as you leave a thread back to the complete system and where it came from. But, over 2000 years ago, we got the first materia medica by the emperor, Shennong, and it's basically an accumulation of knowledge, thousands of years of knowledge. Many, many people contribute to say, "This is what we know so far." There's three categories of herbs, as far as we kind of practise, which is the inferior herbs or lower herbs. They're the ones that are used for disease states. There's a lot of long-term symptoms. We can damage the body. They're basically using poisons, very good in emergency situations and acute illnesses.   Mason: (08:59) And then, middle herbs, regular herbs. They're long-term management of symptoms says still a little bit more... They can go in organs placing those herbs. And then, there's the superior herbs. And the superior herbs can also be used clinically. They are the ones that you can get on the front foot and utilise in the body. The Daoists would say, ``We'd use this to lighten the body or to ward off ageing, ward off premature ageing, to bring the spirit through." So, what is the spirit through is, just imagine, yes, you can develop yourself and use like, say a disease state to gain more perspective and wisdom in life.   Mason: (09:36) But if you don't have to have these disease states to be the catalyst for your growth, if you are already on a path of growth, you don't have to spend all this time going and dealing with disease or symptoms, or whatever, like mental health issues, so on and so forth. If you can do that, then you're going to be able to develop yourself psychologically, you're going to be able to work on your perspective in life, you're going to be able to transition through the initiations of life where you kind of get a little bit less about you at some point, more about the community. And that's what the Daoists were interested in. The superior herbs could be used in that instance. There were some of the grandmas for thousands of years had been, grandpas had been putting in the soup to keep everyone healthy without them knowing.   Mason: (10:17) So, they're the tonic herbs. So, tonic herbs are those that preserve life, and it doesn't mean a lot of people... I've been doing this a long time now and I've been kind of talking. It's been interesting how do I talk about these and get people engaged with these herbs while respecting them, because it's not just the herbs that you can take as much as you want of. They are like herbal foods, but they're still medicinally active. And the whole point of them is, yes, you can take them and it's not like you're going to... It's hard to do damage with these tonic herbs. And that's why they're the lifestyle herbs. But still, people need to be aware that you're going, you need to go slow with these herbs, and sometimes if you're feeling that you need, then you do trust your instinct to start taking big doses of say an extract powder and do two big teaspoons a day.   Mason: (11:05) But then, you need to be able to listen to yourself and that's time to lower that back once again. So, although these are the superior herbs, they're also very active. They're like any food. You're going to want to rotate and keep your instincts alive, but they're the herbs to preserve life. They're the anti-ageing herbs. These are the ones that they use to keep their bones healthy, mind sharp, keep their organs flowing. It's about preserving your life and the Daoist talk about you being made up and everything they made up that your body may be made up of three treasures, especially the three treasures.   Mason: (11:40) Your Jing lives in your kidneys. You're given that when you're born. It's how much wax you have to burn through the candle of your life, right? And so, if you burn the candle at both ends, bang, you're going to get rid of that wax. Yes, Western medicine can keep that flame alive, but keeping a flame alive on just a wick and having no substance there for it to burn through, it's not much of a life to live. And that's why a lot of people die for a long time once they get to 50, 60, 70, they're kept alive, but they're dying for ages. We want to avoid that if possible and that's what the Jing herb's about, not bringing that premature ageing strong bones. They're the foundational essence.   Mason: (12:16) Qi is the second treasure. Qi is like, you take fuel in, you cultivate Qi, keeps the engine going. Keeps your thoughts moving, keeps your fluids moving. This is what keeps you going through every day of life. It's your breath, it's the food that you're taking in, and you can maintain a lot of vitality and a lot of energy by keeping that Qi cultivated. And then, the final treasure is Shen, which is your spirit and your consciousness that comes through. And as you develop more wisdom, that equates to being able to develop more Shen and so more virtuous nature. So, you genuinely cultivate kindness and forgiveness and loving. And then, note that there's other aspects in from consciousness that come from the heart, especially, but there are other organs that you cultivate. Say, for instance, that are going to bring about the wisdom of having really strong boundaries by your really beautiful boundaries, so on and so forth.   Mason: (13:14) So, it's not just all pie-in-the-sky, lovey-dovey shit, quite completely. And that's the theory of Daoism in the organ system, and each organ has its own consciousness. But then, as you keep the Qi going through the organs, the idea is you are not burning through your three treasures. Your Jing, your Qi, your Shen. You cultivate life. That's what tonic herbs are, the superior herbs are. And it contains mushrooms and berries and barks and deer antler velvet, and minerals like pearl. There's some animal ones like a particular type of ant, so on and so forth. And so, in our day and age, they're the ones for like, then nootropics fall into that kind of category a lot of the time. Energy herbs, like ginseng, fall into that category. And a lot of adaptogens fall into that category.   Mason: (14:01) So, clinically, an adaptogen in the west was really identified in the 1970s by the Russians. And they classified, let me see if I've still got this, classify the adaptogen herbs as ones that are going to have an accumulative effect on the body. So, the longer you take them, you're going to accumulate benefits and it's good for everyone to be mindful that that's just not linear, the more your take, gets better. At some point, you hit a glass ceiling of how much energy you can have, and the adaptogens then kind of flesh out and can maybe help you modulate the immune system a little bit more, modulate your nervous system a little bit more. So, it's not just getting better in one direction.   Mason: (14:41) Once you restore homeostasis within your adrenal, that bottom, I'll talk about the HPA axis in a second, but say your adrenals get back into sync all of a sudden, then you might not keep experiencing more and more benefits from that ginseng or ashwagandha in that same direction. You might start opening up to being able to experience benefits in other directions, if you're not attached to just external gains coming from the adaptogen. So, I just need to flesh that one out there. Second classification of adaptogens is it can create any additional harm or stress to the body. The general rules, taking things like ashwagandha, ginsengs, schizandras, reishis, chagas, these kinds of herbs. For the majority of the population who are symptomatic and are dealing with disease states, they're not going to move you into harm or stress place. They're going to help your body adapt to stress, right?   Mason: (15:38) And so, they're regulators. And especially the mushrooms, they're immunological regulators. As well, if you're very sick, you don't just go charging into taking adaptogens. You want to still be... That's a very general kind of classification, as well, and no more harm or stress. And then, the third one I kind of touched on is their regulatory. They have a non-specific action in the body. And so, we generally know that it's going to take cortisol down and the majority of the population's say for ashwagandha cycle, a lot of these herbs, because [everyone's 00:16:11] high. But what about instances where cortisol is low? There are instances where it's actually helping the body get back and increasing that cortisol to a healthy level at appropriate times during the day.   Mason: (16:20) So, that's non-specific. That's like the medicinal mushrooms are used in auto-immune conditions. When people look at them like a reishi and cordyceps, they want to be working with a practitioner. This is you with autoimmunity. But you're looking at those herbs and you're like, "Wow, they're really incredible for lifting the immune system, helping us adapt to pathogenic influx, and fight these things off." But then, there's really solid instances and data coming through around people who are really excessive in their immune activity to the extent where the immune system attacking itself in autoimmune conditions and mushrooms are used to regulate that immune function down. Too very handy having such sophisticated medicine doing that, rather than just using a drug to suppress the immune system. You're going one step further and going where's the trigger site for this unhealthy flurry of pro-inflammatory immune activity and let's go and start regulating the immune system down on that level in an inappropriate way.   Mason: (17:18) So, you're not taking the whole immune system down. You might just be taking a certain part of the immune system down and maintaining surface immunity, right? When you take complete immune suppressants, you're going to see... And then, you're going to be more likely to get sick. That's what an adaptogen is, those three things. No additional harm or stress to the body, accumulates benefits over the time, non-specific activity in the body. And the medicinal mushrooms kind of fall under that banner of a tonic herb, right? And then, some of these herbs in the tropics, adaptogens and nerve veins, and that they're kind of have the Western herbalism, we'll kind of comment on what some of them are, but they're not all adaptogens because some of them are just pure nourishes, right? Some of them like a tremella mushroom, truly beautiful for lubricating the lungs, therefore lubricating the skin. If you've got dry skin, it's just such a nutritive, gentle herb.   Mason: (18:11) And they use a lot in post-surgery or disease states just to get a lot of juice back into the body, and fluid back in the body, and yin essence back into the body, as well as people that just value beauty and vibrance in their skin. It's not really an adaptive fact. They will discover it has slightly adaptogenic elements because it's a medicinal mushroom and feeds the immune system. But right now, it's just seen as a nutritive. So, it's not clinically adaptogenic, but it is a tonic herb. It is a herb that can be used to cultivate Jing, Qi, Shen, which is that's what a tonic herb is. So, the mushrooms come into their medicinal mushrooms, not the culinary portobello kind of brown mushroom ones that you get on your pizza.   Mason: (18:49) I'm not talking about psychedelic mushrooms. We are talking about generally tree-born mushrooms. Those mushrooms like shiitake, maitake, agaricus, poria, Reishi, lion's mane, cordyceps, is grows off caterpillars. We can't do that in terms of a product. It's generally going to be a... For us, it's a fermented cordyceps in a VAT, so that's a vegan one, but that's a kind of an example of a nontree-born medicinal mushroom. But, that's generally going to find medicinal mushrooms. The mycelia is going to grow up through the tree and utilise the carbohydrates and basically, eat those carbohydrates. And then, essentially, don't want to personify it and humanise it too much, but essentially, the genitals come out and then we pick those genitals where the spores come out of and utilise those.   Mason: (19:45) And they're so amazing for the body. They're just so regulatory, whether it's immunity, nervous system, endocrine system. And clinically, what the possibility of using these in real specific instances is just endless, but getting onto them preemptively, I mean, it's at this point, it's just too good not to be taking medicinal mushrooms. I think that's a long form answer to your question.   Tommy Moore: (20:13) That's perfect. You've answered that brilliantly. Yeah, and you're so right. There's so much about Western science and medicine that is almost exclusively looking at symptomatology. And of course, this can be effective in short term treatment or acute treatment of particular diseases and getting back to somewhat of a baseline. But what do you do from there? There's so many people who get unwell, say with cancer or a degenerative illness, and all they're doing is managing their symptoms and to me, that doesn't make any sense at all. It makes sense to the point of not causing further damage, but it isn't encouraging people to get healthier and healthier over time. And so, I appreciate how these medicinal herbs and mushrooms are working on our body as they do have that accumulative effect. They're helping us over time to get better and optimise our organ function and our circulatory system over time so that we can firstly, get to baseline and then go beyond that, because science can be quite slow in these fields.   Tommy Moore: (21:26) Often when we're trying to raise money or get funding for research, it has to treat something. And the way you described it earlier with the inferior herbs that you're looking more at disease states and getting someone to baseline level seems to be how our working science and clinical research at the moment. It has to be for someone who's already ill. And so, the Western way of looking at things is almost waiting for that clinical research to prove its efficacy. But as we mentioned earlier, there's probably thousands upon thousands of documented evidence through the Daoist traditions that prove that efficacy without having to go through the Western clinical path.   Tommy Moore: (22:10) But there's so much merit in these medicinal herbs and mushrooms because they can have such a huge impact on our health and our longevity and optimising the way our body works and improving our brain function and our performance. And it really is multidimensional how they do exert their effects in our body. And you began to allude to the anatomy of the mushroom being the mycelium and the fruiting body, because I find it incredibly interesting how both plants and animals evolved from fungus. To understand their anatomy and understand the constituents is really helping us to understand ourselves and how our body functions. So, can you speak to the anatomy of a mushroom and what are some different types of mushrooms and the different parts of the mushrooms that are working to help us?   Mason: (23:05) Yeah, I mean, this is a huge conversation. I got to the point in studying mushrooms, that I was like, there's a reason that the school of, the discipline of mycology exists because it is its own profession and I'm not going to be able to do it justice. I kind of, at one point I was like, cool, I am going to stick to my lane of tonic herbalism because once again, we've got a little bit further down the track and everyone's like, "Can you identify this mushroom and this mushroom?" And I'm like, "Oh my gosh, I definitely do not want to and cannot do that." But in terms of, it's a good question because mushrooms still have an overall stigma and people relate to the word mushrooms as in that's an appropriate blanket term.   Mason: (23:57) Whereas mushrooms are, you think of the plant kingdom and you go, "Yeah," and you know immediately you understand that there's diversity in the plant kingdom. You think in the mushroom kingdom and people are slowly starting to open up and realising that there's more, if not for people's perception of just as much diversity within the mushroom kingdom, different types of mushrooms, different evolutionary parts, styles of reproducing, so on and so forth, vastly different environments, way more so than plant matter with living within the mushroom kingdom. And so, the biggest organisms on the earth, besides the earth itself, have been mushrooms, all of a sudden you can see what our mushrooms are like. We don't even really know. There's all debate about whether they came from the spores, or came from space.   Mason: (24:51) And I know there's definitely been evidence to show that up, right up as far as you can get in the atmosphere, pretty much their spores and sitting up there. And I think that the work, the studies have been done on saying that seeds and spores can survive the vacuum of space. And so, there's all these weird and wonderful theories about them being aliens coming in and helping to... And we know that fungus basically, kind of up there, just after maybe water had such a pivotal role on helping literally everything evolve and everything is, [bay 00:25:28] is reliant on land and is reliant on that fungal system. They're helping whether it's the procreation, whether it's the sprouting of a seed, you see the mycelium within this particular spore, billions of spores, trillions of spores, just sitting dormant within the soil. And you see these symbiotic relationships as that's perf as the seed and the spore, as well as other conditions align that the seed will start to sprout. And then, you'll see a collaborative effort from that spore starting to sprout, all the mycelia coming up and finding. So, the actual body of the...   Mason: (26:03) ... its sprout or the mycelia coming up and finding, so the actual body of the mushroom coming up and helping basically encase and, again, not my area of expertise, but the way I romantically talk about it, create a womb for that seed, and go down and extract minerals from deeper down, and feed that up into the tree, and then be involved within basically that interconnectedness of a forest and interconnectedness of many elements of the world running up in through the trees. And you can see, once the symbiotic relationship evolves through helping to procreate and create a nursery, basically. And then once that tree is an existence, you see a [mycorrhizal 00:26:42] relationship where you'll see the little spindly bits coming off of the mushroom cells. They can drill essentially into the wood, and then they release enzymes so that they can then basically digest externally and then get access to those carbohydrates because there's underground darkness. There's no access to light, so the mushrooms need to get access to their energy source, the carbohydrates, in another way, and that's how they do that.   Mason: (27:09) And then from there, continues to be a collaborative effort in terms of, for many trees, the mycelium growing in through, and then sometimes sprouting out, and then as well as those mushrooms and the mycelia that just sprout their own mushrooms, coming straight up from the soil. So in terms of what they are, I mean very genetically close to humans, mushrooms. We've definitely co-evolved. That's where you can see the immune system seems literally hardwired. So a lot of people know that now we can see we have the endocannabinoid system, it seems like we're actually hardwired some way to have cannabis in our diet, whether it's regularly or not regularly, or just having a top up, or just being around the plant. It's the same way with the way particular [immunopaths 00:27:55] work, where you're taking in compounds from mushrooms. And because we've co-evolved, you can see that the immune system is there waiting to have particular receptors so it can identify fungal invasion and then take it to places where it can invade it off.   Mason: (28:14) Whereas in the medicinal mushrooms, the tree mushrooms, you take that in and, because it's got a high molecular weight, it'll bypass digestion, get into the gut, and then hit immune cells within the lymph tissue in the gut. And it's like a mystery shopper vibe, or it's like playing war games, where we're going to war ... the immune system's like I'm going to war with this, but it's not an actual threat that's coming in. And so what happens is you take on that beta-glucan within the mushroom, and then that macrophage cell will pass through particular pathways and go deeper into the immune system, metabolise that compound, and then spit it out, but it happens to be what it spits out is in perfect formation to hit deeper immune receptors within the innate immune system, which is a bit deeper to get into a constitutional level like that. And then what you see happening is rather than an activation or stimulation of the immune system, you actually see ... Stimulation was the word I meant to use there first, you actually just see an activation of the immune system.   Mason: (29:18) Whereas the lights start turning on, the intelligence starts turning on, an irregulatory capacity can start to occur. And it's just too perfect, those pathways. And it can happen with other substances, but it doesn't seem to happen with such efficacy. And it's not to say that there's definitely indigenous tribes who hadn't identified this and weren't reliant on tree mushrooms, but it's just too perfect. And so we're utilising that, but I mean I've just danced around what I do know about mushrooms, and then obviously taken it back to their implications around herbal medicine and human consumption, which is what I'm comfortable with. But it's a big, wonderful world and I think there's a lot of nostalgia there. At the moment, you can see mushrooms are going off, whether it's culinary, lots of people are back-buying shiitakes and even lion's manes, and it's really getting into mycology pages on Instagram and just going off, the weird and wonderful world of mushrooms. And so it's definitely the wave's broken on everyone.   Mason: (30:21) And huge Facebook pages, amateur identification groups, people going out and wanting to harvest their own mushrooms. It's a huge little underground thing now, and just even around here, in Byron, there's a few specialists mushroom harvesters that deliver those to some of the more fancy or progressive cafes or restaurants, and just chefs doing really cool things. Yeah, it's just nostalgic and for me, offering medicinal mushrooms to people, that's what basically I see happening is they're like, "Oh man, that feels good. It feels really good being on those mushrooms." They just feel it's very protective, it's a very safe place to be. And it just feels like we just had such a deficiency of connection to that world, that mushroom world, so it's nice to see people waking back up to it.   Tommy Moore: (31:10) Yeah, definitely. And just to continue that topic of this wonderful, intricate interconnectedness or this symbiotic relationship that we have with everything else and that everything else has with us, because it's something like 92% of trees depend on the mycelial network to exchange nutrients and to have conversations with each other. So the trees almost represent our organs and the exchange of nutrients that happens at each of those organs, and the mycelial network is, I guess, like our neural network, and our central nervous system, and peripheral nervous system that's all working together in this beautiful harmony, and creating this wonderful symphony that is our human body. I suppose, for some people, this might sound a little bit woo-woo or spiritual, but I guess it is a little bit like that.   Mason: (32:04) It is a bit, and look, there's a lot you got to ... As I said earlier, I'm quite romantic sometimes when I talk about these things and I'll just shoot past what's been shown within the data. I'm in a good place with our herbal tradition because I walk a very traditional path and chose not to become a practitioner, but rather I work with a lot of practitioners. I have a lot of practitioners coming onto my podcast. We always advise people once we get past a certain lifestyle. It's like if someone is sick and all of a sudden it's no longer just getting good sleep, and getting hydrated, and making some food changes, if that's not an appropriate thing at the moment because their symptoms have gone beyond just having that advice, that's when it also goes beyond tonic herbalism in terms of going, "Just take this and this will help." So because I've created that for myself, yes, the scientific literature is slowly catching up to what's known, and that's fine because you just get realistic about how the Western mentality works, and it's going to require that legitimization, and it's going to be scrutinised.   Mason: (33:20) And sometimes it is rightfully scrutinising because the wellness scene, and I'm guilty of this back when I first started out, you get a little bit over excited, you get a little bit counter-culture, and you start just saying these extreme things, which perhaps are rooted in truth, but you start saying them with no nuance, with such conviction, when maybe you're saying it with conviction maybe because you were in a group that believes it or because your person that you idolise says it, and you haven't actually gone back to the source of why that's been said, and so you don't know where someone might be taking a little bit of liberty to say something that's whatever. You're not at the source of it. So it's a good balancing measure, I find, but nonetheless, I mean, for me, it's just like the grandma's not scientifically adding Poria mushroom and reishi mushroom into a broth. You don't need that scientifically validated. Maybe toxicology reports are really good. People can make sure that there's no significant interactions with drugs that people are on in the family.   Mason: (34:25) But at some point, why I like the herbs is it gets you perceptive of your body. And I like sourcing in a particular way that's [Di Dao 00:34:34], where the herbs are grown as closely as possible, if not wild, in consortium with the elements around them. Living on wild spring water or completely rural areas. And people can go to superfeast.com.au and see photos and get videos of me up there, high mountains or low valleys. It's just in such a shit to get to these places in China. And why do we go to China? Because no-one's growing these tonic herbs. And you can't grow Di Dao these herbs wild on wild wood, say for the mushroom instance. And the other thing about Di Dao is the spore or the seed needs to come from the microclimate. So in that textbook I told you about earlier, the Materia Medica, [Shennong Ben Cao Jing 00:35:19]. And he says you need to go to this province and in this microclimate, that's where you get the best reishi. That's where you get the best [Schisandra 00:35:27].   Mason: (35:27) And so that's what I do. That's what we do. We can look at doing it elsewhere and in other ways, but you're not going to get the best. And I want to preserve that tradition. That's just what I'm doing. And there's other options out there. And then we test for metals, and aflatoxins, and pesticides, and all those things at TGA Labs, and so it's an extremely clean product you're going to be getting every single time. I mean when you start connecting, you're talking about there's that crossing over of spirit and science, at some point, it's rather than even crossing them over, if you have the capacity to hold your awareness of each at the same time is when you start getting this beautiful integration, you have respect, real deep ... that's not right, reverence of both of those spaces, rather in the beginning, it's nice to try and watch where they splice over. We were talking about this. Science is explaining that that's the spirit, that must be what spirit is, you watch the mind again take over. Whereas if you can just hold this spaciousness within yourself and respect both paths, and you hold them in your mind, and in your heart, and then in your gut together without trying to layer them over each other, all of a sudden you become this bridge of awareness of where the crossover is, and you don't need to try and do it too consciously. Some people are specialising in that, and it's really fascinating, but for your own benefit, because the science and the way our culture's bent, we'll generally take all the spirit and the romance out of that style of herbalism. And if you're constantly looking for gains and outputs, you go back and you check in with those things to associate yourself every now and then. It's good to document what actually happened and how they hit that goal. Maybe the herbs contributed or you can definitely see an increase, or you start taking it and you've got an aura ring on, or something like that, and you immediately see you're able to sleep longer and deeper because you're taking a herb. That shit is epic. I absolutely love it.   Mason: (37:27) But nothing beats saying when you get onto Jing Herbs, talking about Jing being the kidney foundations, you've been exhausted. You might be doing panels of cortisol levels because you might have a practitioner who lucky enough is into adaptogens, because they like measuring the HPA access, the hypothalamic pituitary adrenal axis, you know that if you've got that healthy, that axis in your body, that you are able to handle stress with much more efficacy, and therefore they get you on adaptogens, and they test your panels, and they go, "Wow, you're actually getting better." Now, that's all well and good, but they might get a new one, we've got a formula called Jing, it's just replenishing when people are exhausted. We get them replenishing back those foundations. Now yes, getting those inputs and going wow, your mind can go, "This thing is effective. We like doing that," but nothing beats your capacity to observe you building back and cultivating the functions of your organs and the flow of your chi yourself. That can never be forgotten within your body. You develop a very deep memory, and part of that memory is wow, I can do this.   Mason: (38:38) This isn't me going to a practitioner or me just taking a herb, and that practitioner or herb doing something for me. Those are good, but we don't want to do that our whole lives because that can excessively form a dependence externally. And we don't want to become too prudish in rejecting those kinds of things either because that will lead to extremism, going, "No, I never need to go and see a doctor. I never need to go. I can do it all myself," and that's when people can get into shit in the extreme wellness community, or conspiracy theory community, just that excessive world. If you can start though just to watch the fact that you are partaking in a practise, which is say herbalism or whatever, slow, gentle movement, energetic practise, you're meditating, and you watch yourself cultivate that energy and get a little bit more space from when you react to a situation, you're able to, with more ease, get yourself up out of bed in the morning, and go move, and get that yang energy moving.   Mason: (39:38) And then you're able to consciously come down and descend with the yin energy at night, and really participate in making your sleep practise better. That's all you, and even though you'd made to be taking a herbal, this Jing formula, you feel yourself building back that kidney function, which then correlates to adrenals, HPA axis, not feeling as exhausted, but it installs a sense of sovereignty and not dependence. And that's why it's nice for you to be able to go into a tradition that's grassroots and folksy, because it doesn't excessively separate you from your capacity to self-regulate, which is what the full excessive Western model does. It just creates divides and cuts things. It's a scalpel. It's just a scalpel. It's what they do in anatomy, they just cut things apart, and they can't relate then to a part of the body, like the knee relating to the neck, or the liver relating to the nervous system. They just don't get it because they've already got a scalpel and they've cut through all the fascia that connects the whole body.   Mason: (40:46) And they haven't attempted to understand the body as a whole, which is super useful at times, and super not at other times, which is why there's epidemics of degenerative disease, and metabolic disease, and people wasting away, and people just not having any capacity to look after themselves in their older age, which is bullshit, and it's extremist, and it's a dangerous perspective. It doesn't mean we throw the baby out with the bathwater. That's why we need more mature people, people that aren't married to an institutionalised way of thinking, they're not dying on the hill just because they've been educated in a certain way. It's just such a boring, immature, way of looking at the world. And I don't know who these people think they are. The amount of all-knowing people on the internet, I think, is such a crock of shit. And I think it's the benefit for everyone, why I like using these herbs, I talk about becoming less of an asshole and more of an awesome, genuine self. I talk about myself specifically a lot. I definitely don't feel any ...   Mason: (41:53) Just the next trap is feeling the superiority because you're someone that can hold that middle place. It's like no, that's another little trap there. But generally, why I like the philosophy of tonic herbalism is because it can make people not only malleable, it can keep you agile. Doesn't mean as you get more into yourself and go along this path, which so many people are doing, millions, you become more principled in your perspective but you become agile within that principle. You're not projecting. As the organs get into flow and you develop, in general, through life, which is the whole point of these herbs is to help you develop through life, through different stages. And some stages, you just need to go into fully in order to get that perspective of wow, now I can integrate that and go down another path, or go into another stage. But the whole point of these herbs is to support that development so we have people who have wisdom and we don't have these people who get so externally identified with a label, or with a profession, or with an institution that becomes their identity for life.   Mason: (43:12) And therefore, I find that person to be really boring and I find it boring when I do it. And what you want, I think, is just to go on a malleable path and just find what self agency means to you. And that's all we're doing through the herbs. That's all I can hope for. I don't necessarily have an agenda anymore because I just don't assume to know what's right for anyone out there. So that's why I'm also, I feel really open and welcoming whenever anyone here is like, "This is what I want to work on in myself," and I'm like, "Yeah, amazing." Just having a health intention, and if you trust yourself, and go in that direction of an intent, and develop yourself, and stay malleable, the whole idea of the herbs is just to uncrack that stuckness as much as possible, lighten you up so that you can further develop, and same with exercise and hydration, sunlight, and all those good things. But yeah, it's good. There've been people getting perception, which can't ever be taken away.   Tommy Moore: (44:20) Yeah, there are too many people who are very much self identified and there is a huge place for certain herbs and mushrooms to, I guess, dissolve this sense of self identity and really move away from this man made self, and be more perceptual and sensitive to bodily sensations, and be more connected to yourself. I actually want to divert this conversation-   Mason: (44:49) [crosstalk 00:44:49] psychedelic mushrooms as well, go into that conversation as well.   Tommy Moore: (44:51) Well absolutely. Yeah, it's interesting that you bring that up because I do volunteer for a charity called Mind Medicine Australia, and they're actually looking at psychedelic-assisted psychotherapy for mental illness.   Mason: (45:04) How far along are they? Mind Medicine Australia, are they doing the certifications? Is that right?   Tommy Moore: (45:11) Yeah, so we're in discussion with the TGA at the moment, so we're in the rescheduling process. There's an interim decision that's been made. So I know CBD has been accepted in that interim decision, [crosstalk 00:45:23]-   Mason: (45:24) You can put me in touch. Who's heading it? Because I'd love to chat with them a little bit [crosstalk 00:45:30].   Tommy Moore: (45:30) Yeah, totally. So it's Tania de Jong and Peter Hunt. So they're the two co-founders, but we've got a huge advisory board, from researchers, and philosophers, and people all over the world who are looking at this pretty closely. I know a lot of people in the States are, people like Rick Doblin, or Dennis McKenna, or people like that.   Mason: (45:50) Oh man, I'm so keen because this area is massive. I mean this is where people ask me all the time, "And what about psychedelic mushrooms?" and it's the same. And psychedelic mushrooms, brought it up on my podcast recently, I had someone who really explored psychedelic mushrooms, and I'm like, "Oh man, everyone always thinks just by osmosis, I'm going to be taking a lot of psilocybin-containing mushrooms," and the guy who was there, he's like, "I would never think that. I can tell straight away." And I'm not saying, "Yeah, because you're not conscious, man. You can tell that for sure." But I do get that, people like, "Oh yeah, well where can I get the psilocybin psychedelic mushrooms? You must be into them. Let's talk about them." I'm like I've got good things to say, but like mycology, I do stick to my lane now.   Mason: (46:41) And then you're working in the ... And the benefit of having that angle is it opens me up to going, "Yeah, cool." And then I'll talk to people like Tanya and yourself, who have actually got the insight of what's what's going on. I like just sitting on the sidelines, to an extent, and just be an observer of that, and just chat about it, because I mean we've been talking a lot about suicide just behind the scenes here, and on the podcast, it's been coming up. Anyway, I won't go into it right now, but just even for that preventative, I'm pretty sure ... Do you guys have that as a focus around [crosstalk 00:47:22]?   Tommy Moore: (47:22) Yeah, I mean the whole spectrum of mental health really within Australia, we look at the stats, we look at the lack of treatment options, and then we look at the statistics based on what we're seeing with psychedelic-assisted psychotherapy in trials that are happening all over the world. And the neuroimaging side of things, like Robin Carhart-Harris and David Nutt are doing over in Imperial College London.   Mason: (47:43) Who are they? The neuroimaging?   Tommy Moore: (47:46) Yeah, absolutely. So David Nutt and Robin Carhart-Harris are leading a lot of the trials over in Imperial College London. So they're, I guess, head of the Centre for Psychedelic Research as far as I'm aware. So their centre focuses on the action and clinical use of psychedelics with a particular focus on researching the treatment of depression. And they've done some really, really interesting studies there, obviously looking at the psychedelic state and what's happening at the level of the mind, or sorry, I should say the level of the brain in terms of neuroimaging, and also doing very interesting comparisons between the psychedelic state and the meditative state. They've done some comparisons of neuroimaging between Buddhist monks who have had 10,000 hours or more practise of meditation, and then comparing that to what the brain looks like during psychedelics, and some very, very awesome comparisons that they're finding and the similarities in terms of ego dissolution, and moving away from this mind-made self. But I'm certainly more than happy to chat about this.   Mason: (48:56) I was saying before, when you were talking about the mushrooms somewhat acting ... They act like an immune system. You can see tree-based immunological compounds moving between the mycelia between certain trees and sick trees, and also acting like a nervous system. My download, when I was on a medicine journey years and years ago, was that the mushrooms more relate to the fascial system. And the fact that within the Chinese herbal tradition, the mushrooms are seen as fluid regulators, and regulators of decay as well, they help move decay from the body, and allow it to be just metabolised and transformed. And I just started realising if you look at fascia in the body, just the biggest organ in the body, it's not skin, it's the fascia, and it's now I think technically classified as an organ, and it's such a regulating organ. And if you can maintain, as well as everything else, fascial health, you have a really good chance at staying really ... you have a high ability to stay more adaptable within your physicality. And I see that there's this energetic element to it, that it helps you just integrate experiences.   Mason: (50:17) And if you can stay connected in different parts of your body, which is likely you can see there almost being this photon transfer through the fascia in the body, and therefore how much light there is based on ... information there is based on light. And you can see that you can have information transfers to your body, therefore your body's going to be able to stay, basically what I can see, up to speed on what's going on elsewhere, and you can stay more unified as a whole. And then when I started bringing in mushrooms to the say the plant medicine community, and started seeing just how many of my friends, whether they were serving or whether they were regularly going into ceremonies, just felt a significant impact of taking medicinal mushrooms pre and post, pre especially, just to prepare your body and also ensure that you're not going to destroy your nervous system, that you've got this robustness to get through sometimes just how hardcore these journeys can be, but as well, the medicinal mushrooms afterwards to support the process of integration, huge, man.   Mason: (51:19) It was massive and it was this huge missing link. And I think as well, for anyone, it just goes to show it's not just plant medicines, when you're doing anything that's deep cathartic, and you're doing deep work with a therapist, whether it's plant medicine, you're deep diving in your yogic meditative practices, and so on and so forth, you can't just stay deep in these huge mind-exploding experiences. You can't get reliant, I think, long term on that being what's going to fix you or heal you. You go deep, you release the pressure valve, hopefully reduce some acute symptomatology, and then you will need to be able to catch yourself back up on ... If you've blown yourself out into the sky and you've gone deep into your psyche, you need to be able to hit that middle-   Mason: (52:03) Blind yourself out into the sky and you've gone deep into your psyche. You need to be able to hit that middle ground and come back to your lifestyle and your personal everyday practises, your own meditative practise, your own gentle movement practise and your own herbal practise in order to ensure that you're staying level and not becoming, again, externally reliant. Can happen on Western medicine, can happen on these plant medicines. It can happen with whatever, deep dive therapy, deep dive meditations. And, that's, where's the self agency. And that's where I really find the mushrooms to be super useful. And generally the tonic herbs, they're massive, and they are now that you see practitioners of all lights utilising them and getting their clients on these tonic herbs, as well as ensuring that they've just got their lifestyle factors rock solid. And you've got this constitutional discipline and the way you live your life to give yourself these basics, so as well as sleep and diet and all these things, because it's necessary, if you want to evolve in these areas, it's just paramount. Otherwise you can just keep on. You see all the good research in the beginning, because it's under watchful eyes and experts, whether it's a Shaman or whether it's a practitioner, they're a psychologist utilising psychedelic mushrooms or MDMA in all these other places. And there's a facilitation process, but if you aren't moving along on your own accord, if you keep on relying externally, you can start and you don't do so under a real watchful eye and someone that isn't just thinking, yeah, the more, the better, you come back and we'll keep you moving ahead using this thing, you start to loop in these subconscious kind of states rather than actually having the capacity to move slowly beyond them.   Mason: (53:43) And that's just important for everyone to remember that it always, from my perspective it's why I like the tonic herbals. It's like at some point, don't be relying on the external practise or the substance. Come back to your lifestyle. It's like the Buddhists and they're like chop wood carry water, that's where the magic happens when you've been chopping wood carrying water for 20 years and 30 years. And then you get a little insight, then you move past it and you just keep on doing your chop wood, carry water. Everyone needs to remember that it is in this scene because everyone's suckling at the teat of someone who does it for me. To get the research out there that discovers the therapy, that's going to help fix me inside. And I relate to it a lot in my early days as a big seeker.   Mason: (54:24) And it's just a really important reminder, I think for everyone to just constantly and now, if you can, as soon as you can, land with two feet on the ground and just keep your feet on the ground in that disciplined state. And I think then you can really start unlocking the magic. And if you're feeling dependent, unless you're in a dependent state where you find it's a really useful collaboration that you are working with it to get your head above the ground so you can work. But if you're feeling quite stable and you're still ambiguously, keep going back to look for some, there's got to be something more there for me, it helped me so much before. And now there must be other stuff. It's probably that seeking energy without acute symptomatology is there. It's probably time to just put all that aside for probably a few years. And so, anyway, just want to throw that out there.   Tommy Moore: (55:17) Yeah, absolutely. And just while we are on the topic of psychedelic mushrooms, I do think it's important that I bring across what is the therapeutic mechanism of something like psilocybin and psilocybin being the active constituent in psilocybe mushrooms. Now, I don't want to lose anyone in the chemistry of psilocybin because as we know, scientists and researchers are always using complex names. So stay with me as much as you can. I'll do my best to simplify some of the complex words that I'm going to discuss.   Tommy Moore: (55:51) But when we are studying the mind and studying the brain through material science, we do need to understand our limitations. We know that changes in brain activity or changes in blood redistribution within different areas of the brain can cause alterations in our state of consciousness, but we can't necessarily say, or don't necessarily know for sure where or how they exist. That is to say how we consciously perceive them.   Tommy Moore: (56:18) So firstly, let's just recognise the distinction or disassociate brain and mind. Do thoughts simply appear as electrical signals? Can we see thoughts through observing the brain? So I guess the three therapeutic mechanisms of something like a psychedelic mushroom, or all classic psychedelics being things DMT or LSD, neuroplasticity, functional connectivity, and modulation of the default mode network, and they're all correlating positive therapeutic outcomes of being more connected. I alluded to earlier, this feeling of connection to other people, to the greater good, to the universe, to ourselves, to everything. Feeling boundless, wonder, ineffability and a sense of gratitude for this human experience. And I did speak to the sense of ego disillusion, which is often referring to a psychedelic experience. And that is an experience that is beyond this level of mind, that we so often associate with our default state. Now, of course, people are going to have their own connotations and associated perceptions of the word ego, but let's start with that first therapeutic mechanism that I mentioned, which is neuroplasticity. And I know neuroplasticity can be linked with other herbs and medicines like lion's mane.   Mason: (57:46) There's another one. I completely mind blanking ironically when talking about herb's for neuro-plasticity. There was another one the other day and someone was using it. Maybe we're talking about niacin, we're talking about maybe the use of Ginkgo biloba rather than niacin. So more for that diluting factor using herbals rather than B3. So yeah, lion's mane, I think that's quite well established and there's a bajillion people now, thankfully doing lion's mane and microdosing in their own little settings. And I'm sure they're all legal. I was talking about neuroplasticity the other day in terms of a woman doing a masters on adaptogens and mental health. And she's a naturopath. And just going through the mechanisms in which neuro-plasticity is maintained. And it was nice because people use lion's mane and these nootropics. These other nootropics, herbal nootropics like ashwagandha and Rhodiola and Macuna and to an extent Ginkgo biloba. They use them in a way that's either healing.   Mason: (58:59) I use them on my mum on a traumatic brain injury, an acquired brain injury aneurysm. Or for study and mental output and mental acuity. And so they're good, not saying [inaudible 00:59:13] but then there's no grounding factor of just, if you can maintain your neuro-plasticity, you are less likely to find yourself in roadblocks that stop your psychological development or stop you from hopefully, we'll have to look at the data, but stop you from getting a neuro degenerative disease state later in life. And so that is exciting because I had this really calm relationship to neuro-plasticity, which is what I think it needs. I think the nootropic and the neuroplastic seen as far as herb's needs, needs to calm chop wood carry water association as well. So yeah, I'm excited about that side as well. Sorry for cutting you off.   Tommy Moore: (59:56) No, that's all good. Yeah. Just on neuroplasticity, I guess it is quite adaptogenic in a way, because the way most people think of neuroplasticity is just getting smarter or, very linked with the nootropic side of things like alertness and stimulation, but neuroplasticity in much the same way adaptogens work, is that it's progressive over time, you don't grow these neural pathways in a day or even a couple of days, it happens over weeks or months. And so if we're talking about neural pathways in the sense of a thought pattern and these neural pathways that are built up over time, it may be a negative bias that we have that is then becoming subconscious because we're using that pathway so often becomes easier to access. And it becomes part of our subconscious state or our default state when we're not necessarily doin

  Join Alex and guest host Dr. Sara Bagley in a discussion of the psychological concepts in the wonderful film based on the book of the same name, written by Dr. Oliver Sacks, Awakenings (1990)! The film stars Robin Williams as a facsimile of Dr. Sacks and Robert De Niro in one of his strongest method roles. We discuss everything you wanted to know about L-Dopa and dopamine, among this wild trip based in truth.   Please leave your feedback on this post, the main site (cinemapsychpod.swanpsych.com), on Facebook (@CinPsyPod), or Twitter (@CinPsyPod). We'd love to hear from you!   Don't forget to check out our Patreon and/or Paypal links to contribute to this podcast and keep the lights on! Don't forget to check out our MERCH STORE for some great merch with our logo!   Full episode notes here.

Levodopa/L-Dopa termasuk dalam golongan obat khusus yang menjadi suatu kewajiban ain yang harus diminum penderita Parkinson. Banyak pertanyaan mengenai aku dan levodopa. Monggo silahkan

I am incredibly excited to have a very special guest on the podcast today. Not only because he is just one of the biggest experts I know concerning herbalism, health and wellness in general, but because he's a dear friend of mine, Sage Dammers. Sage is the creator and co-founder of Addictive Wellness, which is this amazing company tha tproduces the best adaptogen-enhanced chocolates on the whole planet and the most amazing tasting elixirs. Sage has massively raised the bar on what it means to bring high integrity, cutting edge health and wellness products to the world. In my conversation with Sage, you'll hear:02:55 How Sage got into Tonic Herbalism and extending health span 08:58 The first herb Sage studied and applied Mucuna Pruriens, the „happy herb“ with the highest natural source of L-Dopa, precursor of dopamine 09:44 Sage‘s Happy Hot Chocolate Smoothie recipe for parties 11:09 Astragalus, the ultimate Chi tonic, enhancing energy, vitality, lung health, skin, cognitive and immune function 13:56 The Taoist Herbal World, structure and theory: The Three Treasures: Jing, Qi, Shen and how to support them 19:19 Reishi mushroom, Varieties of reishi, What to watch out for when buying it The ultimate reishi, alpha glucans beta glucans 25:26 Adaptogenic compounds: what they are and what they do 26:54 Why China is a great place for sourcing herbs from pristine eco-systems 30:51 Starting the tonic herb journey: top herbs to start with and what to look out for 35:22 Tonic Herbs for children and how to get them good sleep routine 37:40 Why 80% of Americans are chronically magnesium deficient, magnesium varieties 40:43 Tonic Herbs and sexual health and high performance Ejaculatory control for men based on herbal protocols How men can have multiple orgasms Herbs that boost sex drive and performance 47:55 Why testosterone is very important for women as well 49:02 Why it is important to take Vitamin D3 with Vitamin K2 49:35 How to enhance your resilience to stress 51:43 Spiritual effects of Tonic Herbs and how they can support self actualization individually and for humanity 59:22 Thyroid health and the connection to hair growth 01:01:09 Ariane‘s recipe for Goji - Schizandra Berry Tea, the ultimate beauty tonic 01:02:56 The benefits of raw cacao and the different strains of cacao 01:09:00 The health benefits of Xylitol and which one to choose 01:10:20 What is a Stevia Supertaster? 01:13:58 Why Arriba Nacional Cacao is the best variety for human health and also for the health on the planet 01:14:47 The DI TAO PRINCIPLE of herbalism 01:18:17 Sage‘s practices Resources mentioned:http://www.sagedammers.com/ (Sage Dammers) http://www.addictivewellness.com/ (Addictive Wellness) http://www.instagram.com/addictivewellness (Instagram) http://www.facebook.com/AddictiveWellness (Facebook ) https://amzn.to/2YvFWKN (The Tao of Health Sex and Longevity)

In this episode we discuss the effects of chronic Parkinson's treatment, deep brain stimulation, and other treatment options that are recommended to manage side effects of continuous treatment. Transcript can be found here.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.26.354688v1?rss=1 Authors: Thoener, J., Koenig, C., Weiglein, A., Toshima, N., Mancini, N., Amin, F., Schleyer, M. Abstract: Across the animal kingdom, dopamine plays a crucial role in conferring reinforcement signals that teach animals about the causal structure of the world. In the fruit fly Drosophila melanogaster, the dopamine system has largely been studied using a rich genetic toolbox. Here, we suggest a complementary pharmacological approach applying the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine (3IY), which causes acute systemic inhibition of dopamine signaling. Using Pavlovian conditioning, across developmental stages (3rd instar larva versus adult), valence domains (reward versus punishment), and types of reinforcement (natural versus optogenetically induced), we find that 3IY feeding specifically impairs associative learning, whereas additional feeding of L-3,4-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, rescues this impairment. This study establishes a simple, quick, and comparably low-cost approach that can be combined with the available genetic tools to manipulate and clarify the functions of the dopaminergic system - in D. melanogaster and other animals. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.24.308122v1?rss=1 Authors: Sharma, A., Vidaurre, D., Schnitzler, A., Vesper, J., Florin, E. Abstract: Pathological oscillations are a hallmark of neural activity in Parkinsons disease (PD). Time-averaged analyses are usually employed to study changes in spectral connectivity with and without dopaminergic intervention in PD. This prevents differentiating the pathological vs physiological nature of dynamically evolving oscillatory activity serving multiple functional roles. Using a Hidden Markov Model on combined STN-LFP and whole-brain MEG data from 17 PD patients we discovered three distinct network activity patterns. One network was related to adverse effects of increased dopamine, a second one maintained ON-medication spatio-spectrally selective cortico-STN connectivity and finally, a local STN-STN network emerged which indicated the inability of L-DOPA to modify local basal ganglia activity. Temporally we found that, ON medication, the cortico-STN and the STN-STN network increased in duration whereas the cortico-cortical network occurred less frequently. Our results provide a spectrally diverse and spatially specific understanding of transient network connectivity in PD on a whole-brain level, disambiguating temporal and spatial changes of the underlying networks. By providing electrophysiological evidence for the differential effects of L-DOPA intervention in PD, our findings open further avenues for electrical and pharmacological intervention in PD. Copy rights belong to original authors. Visit the link for more info

Welcome back for another episode of Nick’s Non-fiction with your host Nick Muniz! In Awakenings, one of the top selling non-fiction books of all time, we take a trip to Mt. Carmel, NY to meet post-encephalatic patients, reviewing their life from a vessel which they’ve been trapped inside. Dr. Sacks was one of the leading researchers in the fight against Parkinson’s being the first to have assembled a history of the disease. In order to combat this amalgamation of malfunctions, Shock said the medical community needs to combine resources and focus attention on finding causes rather than treating side effects. Like a leukemia patient mustering every bit of strength and technology within their means to rid themselves of cancer, the pharmaceutical industry would need to unite to put to rest this end of life mental degeneration. This book accounts the introduction of L-DOPA a dopamine antagonizer that revitalized catatonic patients to a level of youth they didn't know was within them. Before an age where 1/8 of people are on antidepressants, Dr. Shock found the key to a healthy sustainable life is holding onto that enlightenment and continuously refining the sense of self. Subscribe, Share, Mobile links & Time-stamps below! 0:01:05 Introduction 0:04:40 About the Author 0:08:00 Ch1: Parkinson’s & Sleeping Sickness 0:21:40 Ch2: Frances D. 0:30:25 Ch3: Magda B. 0:35:00 Ch4: Lucky K. 0:40:45 Ch5: Ida T. 0:44:25 Ch6: Aaron E. 0:49:55 Ch7: Leonard L. 0:53:30 Ch8: Perspectives 1:03:15 Ch9:Tribulations 1:10:45 Ch10: Epilogue 1:15:45 Next Time & Goodbye! YouTube: https://youtu.be/EO_lcDZ5mzs iTunes: https://podcasts.apple.com/us/podcast/nicks-non-fiction/id1450771426 Thanks for Stopping By!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.03.235077v1?rss=1 Authors: Soares, D. M. M., Goncalves, L. C. P., Machado, C. O., Esteves, L. C., Stevani, C. V., Oliveira, C. C., Dorr, F. A., Pinto, E., Adachi, F. M. M., Hotta, C. T., Bastos, E. L. Abstract: L-DOPA extradiol dioxygenases (DODAs) catalyze the production of betalains and hygroaurins pigments. The sequence of the DODAs found in Caryophyllales and Basidiomycetes are not conserved, although betalains are produced both by plants and fungi. Here we revise the coding region of the dodA gene of fly agaric [Amanita muscaria (L.) Lam.] and describe an alternative start codon downstream that enables the heterologous expression of AmDODA, a promiscuous L-DOPA dioxygenase. AmDODA is 43-amino acid residues shorter than the recombinant DODA previously reported but catalyzes the formation of two isomeric seco-DOPAs that are the biosynthetic precursors of betalains and hygroaurins. The putative active site of AmDODA contains two distinct His-His-Glu motifs that can explain the dual cleavage of L-DOPA according to the mechanism proposed for non-heme iron-dependent dioxygenases. Upon addition of excess L-DOPA, both the betaxanthin and hygroaurin adducts of L-DOPA are produced. The kinetic parameters of enzymatic catalysis at pH 8.5 are similar to those reported for other L-DOPA dioxygenases. The rate constants for the conversion of L-DOPA into the betalamic acid and muscaflavin were estimated by kinetic modelling allowing the proposal of a mechanism of pigment formation. These results contribute to understanding the biosynthesis of bacterial, fungal and plant pigments, for the biotechnological production of hygroaurins, and for the development of more promiscuous dioxygenases for environmental remediation. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.13.199224v1?rss=1 Authors: Troisi Lopez, E., Minino, R., Sorrentino, P., Rucco, R., Carotenuto, A., Agosti, V., Tafuri, D., Manzo, V., Liparoti, M., Sorrentino, G. Abstract: BACKGROUND: Parkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. In this paper, we build upon the idea that the trunk is crucial in balance control. Hence, we have designed a new measure of postural stability which assess the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI). METHODS: Twenty-three PD patients and twenty-three healthy controls underwent clinical (UPDRS-III) and motor examination (3D gait analysis). The TDI was extracted from kinematic measurements using a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with typical gait parameters, to verify its biomechanical value, and UPDRS-III, to observe its clinical relevance. Finally, its sensitivity was measured, comparing pre- and post- L-DOPA subclinical intake. RESULTS: The TDI showed significant correlations with many gait parameters, including both velocity and stability characteristics of gait, and with the UPDRS-III. Finally, the TDI resulted capable in discriminating between off and on state in PD, whereas typical gait parameters failed two show any difference between those two conditions. CONCLUSIONS: Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.23.112375v1?rss=1 Authors: Isotalus, H. K., Carr, W. J., Averill, G. G., Radtke, O., Selwood, J., Williams, R., Ford, E., McCullagh, L., McErlane, J., O'Donnell, C. K., Durant, C., Bartsch, U., Jones, M. W., Munoz Neira, C., Wearn, A. R., Grogan, J. P., Coulthard, E. J. Abstract: The human brain selectively stores knowledge of the world to optimise future behaviour, automatically rehearsing, contextualising or discarding information to create a robust record of experiences. Storage or forgetting evolves over time, particularly during sleep. We sought to test how dopamine shaped long term memory formation before and during sleep. We administered dopamine (L-DOPA tablet) during learning, re-learning, consolidation or retrieval of word lists in two independent double-blind randomised placebo-controlled cross-over studies of healthy older adults (study 1 n = 35, study 2 n = 32). During consolidation, nocturnal dopamine accelerated forgetting for words presented once, but did not affect words presented twice from forgetting. Overnight dopamine increased total slow wave sleep duration by approximately 11%. The effect of dopamine on memory correlated with increased spindle amplitude, which was maximised near slow oscillation peaks, suggesting dopamine-dependent memory processing modulates spindles dependent on slow-oscillation phase. Pharmaceutical modification of slow wave sleep holds great promise for improving old age - potential benefits could include cognitive enhancement and Alzheimer's prevention. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.28.063347v1?rss=1 Authors: Radlicka, A., Kaminska, K., Borczyk, M., Piechota, M., Korostynski, M., Pera, J., Lorenc-Koci, E., Rodriguez Parkitna, J. Abstract: The development of Parkinson's disease (PD) causes dysfunction of the frontal cortex, which contributes to hallmark motor symptoms and is regarded as one of the primary causes of the affective and cognitive impairments observed in PD. Treatment with L-DOPA alleviates motor symptoms but has mixed efficacy in restoring normal cognitive functions, which is further complicated by the psychoactive effects of the drug. In this study, we investigated how L-DOPA affects gene expression in the frontal cortex in an animal model of unilateral PD. We performed an RNA-seq analysis of gene expression in the frontal cortex of rats with 6-hydroxydopamine (6-OHDA)-induced unilateral dopaminergic lesion that were treated with L-3,4-dihydroxyphenylalanine (L-DOPA) , for 2 weeks. We used analysis of variance to identify differentially expressed genes and found 48 genes with significantly altered transcript abundance after L-DOPA treatment. We also performed a weighted gene coexpression network analysis (WGCNA), which resulted in the detection of 5 modules consisting of genes with similar expression patterns. The analyses led to three primary observations. First, the changes in gene expression induced by L-DOPA were bilateral, although only one hemisphere was lesioned. Second, the changes were not restricted to neurons but also appeared to emerge in immune or endothelial cells. Finally, comparisons with databases of drug-induced gene expression signatures revealed multiple nonspecific effects, which indicates that a part of the observed response is a common pattern activated by multiple types of pharmaceuticals in different target tissues. Taken together, our results identify cellular mechanisms in the frontal cortex that are involved in the response to L-DOPA treatment. Copy rights belong to original authors. Visit the link for more info

Holistically Speaking is a podcast about holistic health and wellness hosted by Nancy Sacks. Holistic means working with the whole person, including physical, mental, emotional, spiritual and lifestyle. In this podcast Nancy will dive into holistic health, homeopathy, spirituality, quantum healing, natural remedies, and much more. Join as Nancy shares her passion, wisdom, experience, and knowledge to hopefully help you the listener have some of your questions answered. In this episode Nancy goes over the changing of the seasons. In this episode Nancy talks about anxiety and the chemical imbalance that occurs, side effects, symptoms of anxiety, and healthy ways to cope and deal with anxiety in a natural way. Listen as Nancy talks about the mind/gut connection and different excersises, supplements, and breathing techniques to conquer your anxiety and stress! If you balance your bodies chemistry your life will be more balanced. Products mentioned in this podcast;NEUROGFRNeuro GFR: contains a dietary, synergistic blend of 19 biologically-active cofactors that complement the bodys Neuro and Brain functions. It supports the healthy functioning of the brain and nervous system, helping to maintain optimum concentration, attention, learning and motivation.https://holistichavenpharmacy.com/collections/anxiety-depression/products/neurogfrSTRESS FACTORS (60 COUNT)Stress Factors is a blend of nutrients and amino acids designed to nutritionally support an increased parasympathetic response. It is an excellent choice for the nutritional support when you are burned-out, stressed-out and emotionally labile.https://holistichavenpharmacy.com/collections/anxiety-depression/products/stress_factors_60_countNATURAL CALM 16 OZ.Natural Calm - The anti-stress drink; a relaxing magnesium supplement. This product balances your calcium intake and restores healthy magnesium levels which help to prevent muscle cramping, reduce lactic acid buildup and replace magnesium lost during exercise.https://holistichavenpharmacy.com/collections/anxiety-depression/products/natural-calmMAG PLUS ZMA SELECTIs rich in the important minerals that support the anabolic processes of the muscular and skeletal structures in the body.Each capsule of Mag Plus ZMA Select contains about the same amount of magnesium as six medium sized bananas or 1 cups of cooked spinach.https://holistichavenpharmacy.com/collections/anxiety-depression/products/magpluszmaselectCALMDesigned to help promote a feeling of calmness and relaxation during times of stress. CALM provides nutrients that play a role in the synthesis of neurotransmitters, such as serotonin and dopamine with L-Dopa and SAMe. Supports a positive mood by providing nutrients that promote healthy methylation and healthy 5-HT and PDE4 modulation with SAMe and Sceletium Tortuosum. Supports a sense of tranquility by modulating the balance between glutamate and GABA with Cordyceps Militaris, Taurine, GABA, green tea catechins, and vitamin B6.https://holistichavenpharmacy.com/collections/anxiety-depression/products/calmANTI-STRESS DROPSDue to Professional Complimentary Health's policies, only patients who have had a consultation with Nancy are eligible to purchase this product. Once you add the item to your shopping cart, you will be able to see the price.Anti Stress Drops use homeopathy in addressing stress-related problems such as anxiety attacks and exhaustion. This product contains Royal Jelly a milky secretion harvested.2 fluid ounces.https://holistichavenpharmacy.com/collections/anxiety-depression/products/anti-stress_dropsKLAIRE LABS TARGET GB-X MOOD BOOSTING PROBIOTICA specialty shelf-stable probiotic formulation targeted to provide robust gut-brain axis support*Clinically demonstrated to support positive mood.*5 billion CFU (9-strain) blend in 30 single-serving sachets, no refrigeration required. Protected by PROBIOACT Technology for optimal efficacy and shelf-stability.*Hypoallergenic* and non-GMO. Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. No artificial additives, colors, flavorings, preservatives, sugar, or salicylates are used. Contains corn.Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner.*Target gb-X is a specialty probiotic formulation targeted to provide robust gut-brain axis support. It is the first probiotic clinically demonstrated to reduce cognitive reactivity to sad mood, decrease rumination, and diminish aggressive thinking.https://holistichavenpharmacy.com/products/klaire-labs-target-gb-x-mood-boosting-probioticDIGESTIVE ENZYMES ULTRA 180 CAPSDigestive Enzymes Ultra contains a high-strength mixture of vegetarian enzymes supporting enhanced protein, carbohydrate, fat, fiber and dairy digestion and promoting optimal nutrient bioavailability and absorption.https://holistichavenpharmacy.com/products/digestiveenzymesLAZARUS NATURALS CBD TINCTUREMade with Full Spectrum Hemp ExtractChoose from 50mg of CBD per 1ml or 15mg per 1mLVegan and gluten-free with no artificial flavors, preservatives or sweetenersIngredients: Organic Hempseed Oil, Fractionated Coconut Oil, Hemp ExtractCONTAINS: Tree Nuts (Coconut)Hemp oil has < 0.3% THC and is not psychoactive, therefore you don't have to worry about any debilitating high.

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Could be used to help support calm, focus, recovery from exercise-induced inflammation, and more.
https://holistichavenpharmacy.com/products/high-potency-cbd-tinctureFor any questions, feel free to email Nancy@holistichaven.com. Be sure to join Holistic Haven's newsletter by signing up on at holistichaven.org. And to purchase holistic and homeopathic remedies visit holistichavenpharmacy.com

The BBB, dopamine and L-Dopa

Rhodium is an expensive precious metal that is used in catalytic convertors, to make the Parkinson's drug L-DOPA, create shiny jewellery and add the menthol taste to toothpaste, says Allan Blackman from AUT in ep 69 of Elemental.

Rhodium is an expensive precious metal that is used in catalytic convertors, to make the Parkinson's drug L-DOPA, create shiny jewellery and add the menthol taste to toothpaste, says Allan Blackman from AUT in ep 69 of Elemental.

Rhodium is an expensive precious metal that is used in catalytic convertors, to make the Parkinson's drug L-DOPA, create shiny jewellery and add the menthol taste to toothpaste, says Allan Blackman from AUT in ep 69 of Elemental.

In Episode 143 of Keto Talk, Jimmy and Dr. Will Cole do a deep dive on the subject of Adaptogens–plant medicines, but not just any old plant medicines– and shine some light on what this means for your health. "I like to think of adaptogens like Captain Planet. When all the forces combined, they saved the day. Adaptogens are a whole kingdom of substances that all work together, but they all have their own strong suits as well." – Dr. Will Cole "Most people can find benefit from these adaptogens in their life right now." – Jimmy Moore What are Adaptogens? Adaptogens are a broad family of herbs and plant medicines that have been used for thousands of years throughout the world. To be labeled an adaptogen, a plant medicine must fulfill at least three specific criteria: They are generally safe (for just about everyone). They help you handle stress. They work to balance your hormones. How adaptogens work Stress and hormone pathways are connected – your body’s stress system, the sympathetic nervous system, controls hundreds of pathways that are responsible for inflammation, and when inflammation gets out of control, this can lead to hormonal problems like adrenal fatigue, low sex drive, and thyroid dysfunction. Adaptogens help to regulate the sympathetic nervous system so everything downstream works better. And because chronic inflammation is linked to many of the common health problems we see today, the medical literature has found adaptogens to have even more cool and far-reaching health benefits like: lowering cortisol levels regenerating brain cells alleviating depression and anxiety protecting heart health protecting the liver preventing and fighting cancer lowering cholesterol protecting against radiation balancing the immune system decreasing fatigue Adaptogen Superstars They all mediate stress, fight inflammation, and bring balance to your hormonal system but each adaptogen also has its own special set of skills. Here are the 12 most popular adaptogens and what you should know about each: 1. Ginseng: The pick-me-up Ginseng varieties, including Asian White, Asian Red, and American White, are great for those seeking an extra boost of energy without the jitters that can come from caffeine. Personally, I especially like to use it to combat jet lag. 2. Pearl: The beauty secret Crushed-up pearl powder is a great source of amino acids and will nourish skin, hair, and nails. 3. Rhodiola: The stress calmer Rhodiola rosea is good for people struggling with adrenal fatigue and fibromyalgia, but it can have a stimulating effect on the extra-sensitive, so take it before noon or it could keep you up at night. 4. Schisandra: The adrenal supporter Another super adrenal supporter, this berry is one I used on a regular basis during my journey recovering from adrenal fatigue. 5. Shilajit: The sex hormone igniter People with low libido or sex hormone imbalance can benefit from shilajit. This Ayurvedic herb’s name translates as “conqueror of mountains and destroyer of weakness.” Sounds good to me. 6. Ashwagandha: The thyroid + mood master A superstar adaptogen, this popular herb is a great tool in supporting optimal thyroid function. If you tend to get mood swings, ashwagandha may also be all the remedy you need. Just watch out – ashwagandha is a nightshade, which may aggravate symptoms (such as joint pain) in some people with autoimmune conditions. 7. Maca: The energizer Maca both boosts energy and calms anxiety. It’s also a rich source of vitamin C, making it an immunity enhancer. There are three types of maca powders: Red, yellow, and black. Red maca is the sweetest and mildest tasting. Yellow maca is the least sweet, and black maca is somewhere in between the two. 8. Holy Basil (Tulsi): The memory booster I recommend holy basil to my patients who complain of brain fog because it gently increases cognitive function. As a bonus, it’s also great for bloating and gas. 9. Ho Shou Wu: The libido pumper-upper Another great tool for people with a low sex drive, this herb has been used for thousands of years in Chinese medicine. 10. Mucuna pruriens: Nature’s chill pill This adaptogenic bean extract is jam-packed with L-DOPA, the precursor to the neurotransmitter dopamine. I take this daily as it helps with focus and calms me down during my busy day. 11. Eleuthero: The battery pack If you are dragging through the day, this herb is another great one for optimizing energy levels. Extra stressful week? Eleuthero is your go-to. 12. Adaptogenic mushrooms Within the adaptogenic kingdom, there is an extra-special group of medicinal mushrooms that offer some of the same hormone-balancing benefits as the adaptogens above and some extra immune-boosting qualities too. These include: Chaga Shiitake Himematsutake Lion’s Mane Turkey Tail Cordyceps Reishi What are adaptogens anyway? Adaptogens encompass a wide variety of different natural medicines from all corners of the globe that have a few things in common: They are generally safe and they have a balancing effect on something called the hypothalamic-pituitary-endocrine axis. This is the delicate dance between your brain and hormone system, and include your brain-adrenal (HPA) axis, brain-thyroid (HPT), and brain-gonadal axis (HPG). You need all these communication systems working in perfect harmony for a healthy mood, metabolism, energy, immune system, and sex drive. When your HP axis is unbalanced it leads to hormone problems like adrenal fatigue, thyroid problems, and libido issues. And nobody wants that. Like the colors of a rainbow or the superhero kids on Captain Planet, the inhabitants of the adaptogenic kingdom sometimes work brilliantly by themselves and sometimes cooperate synergistically with other complementary adaptogens. Usually available in powdered form, you can mix these into your morning coffee, make a caffeine-free tonic, or blend them into your daily smoothie. The next question is: Which ones do you need? Find your current health issue and I’ll give you a list, but always remember to pay attention to how your body responds to anything new. Poor complexion, Brittle nails, or Unhealthy hair: Pearl: This adaptogen of the sea is a great source of amino acids to help nourish hair, skin, and nails. Chaga: This superfood mushroom is loaded with antioxidants that help fight free radicals to keep skin youthful. Cordyceps: This is the ultimate anti-aging adaptogen. Not only does this mushroom increase antioxidants, but it decreases the pro-inflammatory monoamine oxidase and lipid peroxidation activity that causes us to age. Rhaponicum: Full of antioxidants, this root helps to promote cell health, keeping you young and vibrant. Jiaogulan: Consuming this adaptogen can actually help your body increase its production of superoxidase dismutase. This particular antioxidant protects your body’s cells from premature destruction and aging. Stress: Rhodiola: This herb can help reduce stress and is great for people with adrenal fatigue. However, if you are extra sensitive, be careful because it could potentially keep you up at night. Mucuna pruriens: This bean extract is packed with L-DOPA, which is the precursor to the neurotransmitter dopamine. I call this nature’s chill pill. Ashwagandha: Since it has the ability to regulate cortisol, your body’s stress hormone, this is a powerful calming tool to have on hand. Licorice root: Bring stress down with this cortisol-controlling Zen master. Hormone Balance: Schisandra: This berry supports your adrenals and can help fight adrenal fatigue. Cordyceps: For those struggling with adrenal fatigue, this is a great hormone balancer to help increase energy and stamina. Ashwagandha: The ultimate cortisol balancer, this helps to support your brain-adrenal (HPA) axis. This herb is also powerful when it comes to thyroid support. Since adaptogens are balancing in nature, ashwagandha in particular is great at boosting sluggish thyroid hormones. Licorice root: Just like ashwagandha, it helps to heal adrenal fatigue by balancing cortisol levels. Fatigue: Ginseng: Asian white, American white, Asian red, and Siberian (Eleuthero) all boost energy without the caffeine jitters. Maca: This herb is available in three different varieties: red, yellow, and black. Red is the sweetest but most mild tasting. Yellow is the least sweet, and black is right in the middle. They are all great energy boosters. Low Sex Drive: Shilajit: This herb is used in ayurvedic medicine and translates to “conqueror of mountains and destroyer of weakness.” Shilajit helps to lift up low libido and balance sex hormones. He shou wu: If sex were an herb, it would be he shou wu. Used for thousands of years in Chinese medicine, this herb helps increase sex drive in those with low libodos. Mix with shilajit for a sexual health tonic. Brain Fog: Holy basil (Tulsi): Start incorporating this into your wellness routine if you struggle with brain fog as it works to increase cognitive function. Lion’s mane: The nerve growth factors (NGFs) found in this mushroom can help regenerate and protect brain tissue. Rhaponticum: Some studies have shown that this root can stimulate brain activity. Immunity: Maca: Packed with vitamin C, this is a perfect immune booster. Chaga: Studies have shown this mushroom to have powerful antiviral effects as well as immune-balancing properties. Turkey tail: When consumed daily, it has been shown to improve immune function. Ashwagandha: This is traditionally used in ayurvedic medicine to help boost the immune system after being sick. Astragalus: Having strong immune-boosting abilities, this herb has been used to help restore immune function for people with weakened immune systems from cancer treatments or chronic illnesses. In addition, it has powerful antiviral and antibacterial properties. Anxiety and Depression: Lion’s mane: Studies have shown that the consumption of lion’s mane can reduce depression and anxiety. Ashwagandha: Taking ashwagandha has been shown to reduce anxiety by up to 44 percent! Blood Sugar Balance: Reishi: This magic mushroom helps to lower blood sugar levels by down-regulating-alpha-glucosidase, the enzyme responsible for breaking down starches into sugars. Digestive Issues: Holy basil (Tulsi): This little guy works hard to reduce bloating and gas, for those struggling with gut issues. Turkey tail: I often give this adaptogenic mushroom to my patients who are battling gut overgrowths like SIBO or candida. Licorice root: This has been used for years as a common remedy to help heal leaky gut syndrome since it is both soothing and anti-inflammatory. Cancer: Shiitake: Japanese studies have shown that this mushroom has the power to actually decrease tumor growth. Himematsutake: Also known as God’s mushroom, the protein blazein that is found in Himematsutake actually has the ability to kill some cancer cells. Studies have shown that cancer cells died after just a few days of treatment! Where the heck do I buy these? You can find many high-quality, organic adaptogens online and at health foods stores. Some of my favorite brains are Moon Juice, Sun Potion, Four Sigmatic, and Real Mushrooms.  

Human beings have been called "light-eaters." Basically, food is light "slowed down," so that we can ingest it and get energy from it. In today's episode, Dewey Layman explores how the light in our food and our environment shapes our health. He dives into how our brains are wired for light, why it's a good idea to include plenty of seafood in our diet, and how getting enough sunlight can decrease not only our appetite, but the actual amount of food we need to eat to function well. Dewey is the COO of Ra Optics (a blue-blocking glasses company) and the Founder and CEO of L-Dopa, a quantum health consulting company, and, as such, he shares insights from his years of research into light and its effects.   For more from Dewey, visit his website: l-dopaconsulting.com. Check out our sponsors: Mountain Rose Herbs, Vintage Tradition, and Ancestral Supplements. For the full show notes from today's episode and additional resources, visit our website: westonaprice.org.

Depression. Weight gain. Eye problems. Auto-immune conditions. The wrong light can lead to health concerns on a number of fronts. Our computers, cell phones, and indoor lifestyle are jeopardizing our well-being. The blue light, considered "junk light," emitted from many of our devices interferes with our bodies' natural functions, throwing our systems out of whack. Dewey Layman, the founder and CEO of L-Dopa, a quantum health consulting company, understands this first-hand. For a time, he worked the night shift at a pizza shop and played video games till the sun came up. His health took a nosedive. He developed myopia and hormone imbalances; he became overweight and depressed. Turning to the sun, literally, helped turn his life and health around. Today he discusses the importance of exposing ourselves to sunlight for energy and health. He also explains what blue light is, the problems it causes for our circadian rhythm, and how we can mitigate its effects in our lives.  For more from Dewey, visit his website: l-dopaconsulting.com. Visit our website for more resources: westonaprice.org. To join or for more information on membership with WAPF, click here. Take our listener survey here. Check out our sponsors: Vintage Tradition, and Ancestral Supplements. 

The superherb revolution is just like the superfood revolution. We now have access to the most amazing herbs ever discovered. Just like with superfoods in the past, people were limited to the superherbs that grew in their area. Thanks to technological advances, we can easily hop on a computer, push a few buttons, and have the most powerful herbs in the world shipped right to our door. Whereas superfoods are food, superherbs are our medicine. Some superfoods are also considered superherbs, but superherbs are generally more on the medicinal side and less like food. Many of the superherbs can come from wild plants. This is an excellent way to get alkaloids from wild plants in our diet. You can buy them in stores, online, or you can even find them growing wild if you know how. In general, superherbs are typically tonic herbs. Tonic herbs are herbs that can be consumed regularly over long periods of time without you having a negative reaction to them. They're extremely safe and gentle. Tonic herbs are like a hybrid of food and medicine because they're medicinal but you consume them regularly like food. The dual directional nature of tonic herbs allow them to bring the immune system up or down, whichever is necessary. This level of intelligence is extremely beneficial for people who have auto-immune conditions. Some herbs, like garlic, should not be taken every day and they only have the ability to move the immune system in one direction – up. Because we have access to the best herbs from all around the world, it's best to take the top herbs from each herbal medical system and integrate them into your approach. When you combine the best herbs from the Chinese medical system, Ayurvedic medicine, and South American herbalism, you have a cutting-edge strategy that is unsurpassed by anything else in the world. Instead of health insurance it's heath assurance. It's the future of medicine, though it comes from our ancient past. Tip: Make your own tinctures with herbs because you can make them stronger for far less money. Top Superherbs Cat's Claw – extremely potent anti-viral Pau d'Arco – extremely potent anti-fungal Ginseng – Possibly the most famous herb in the world. Stay away from the cheap stuff because it's too young. Wild ginseng is highly prized and gets more expensive as it ages and gains Shen (Spirital) properties. Ginseng should be at least ten years old before you consume it. Highly regarded Shen tonic. Deer Antler – top Jing herb, boosts adrenals. Rejuvenation. Builds muscle. Shilajit – High amounts of fulvic acid. Mucuna – highest known source of L-Dopa. Great for people with Parkinson's Disease. Schizandra Berry – the “five flavored fruit.” Nourishes all three treasures (Jing, Qi, Shen). He Shou Wu - supplements the congenital life force of the kidneys, it improves hair quality and deeply nourishes and rejuvenates the whole body. Astragalus – qi tonic. Excellent for the immune system, energy, and lungs. Eucommia Bark – Excellent for building ligaments and fighting arthritis.

Special Guest: Dr. Angela Cenci Nilsson Why has it taken so long to improve L-dopa delivery so that Parkinson's patients can experience the drug's benefit in a more continuous fashion? A conversation about the latest prospects and the challenges of getting big Pharma to buy in. To listen to more episodes of this podcast, visit our website: www.worldpdcoalition.org/?page=PortlandCountdown

The phone conference features Brian S. McKay, PhD, who conducts basic research towards developing new cell-based therapies for macular degeneration. He discusses a major new breakthrough showing that L-DOPA, a drug widely used to treat Parkinson’s disease, may help protect against age-related macular degeneration (AMD); Maria B. Grant, MD, who conducts research using adult stem cells to repair damaged blood vessel networks within the retina that are associated with macular degeneration; and David Pepperberg, PhD, who researches methods to restore vision lost in diseases such as age-related macular degeneration.

The phone conference features Brian S. McKay, PhD, who conducts basic research towards developing new cell-based therapies for macular degeneration. He discusses a major new breakthrough showing that L-DOPA, a drug widely used to treat Parkinson's disease, may help protect against age-related macular degeneration (AMD); Maria B. Grant, MD, who conducts research using adult stem cells to repair damaged blood vessel networks within the retina that are associated with macular degeneration; and David Pepperberg, PhD, who researches methods to restore vision lost in diseases such as age-related macular degeneration;

The discussion features Brian S. McKay, PhD, who conducts basic research towards developing new cell-based therapies for macular degeneration. He discusses a major new breakthrough showing that L-DOPA, a drug widely used to treat Parkinson's disease, may help protect against age-related macular degeneration (AMD); Maria B. Grant, MD, who conducts research using adult stem cells to repair damaged blood vessel networks within the retina that are associated with macular degeneration; and David Pepperberg, PhD, who researches methods to restore vision lost in diseases such as age-related macular degeneration.

Sexual impotence—a loss of ability to maintain a full erection—affects most men at some time in their lives. It can be the result of feeling unwelcome, afraid of your own power, or experiencing a sense of inadequacy or depression about yourself. Such feelings strongly influence the behavior of your body. And when you can develop real awareness of how your lover feels, with patience and consideration, psychologically-caused impotence will often clear by itself. Other difficulties in maintaining an erection can be biochemical in nature. In men over the age of 35, this often happens during periods of prolonged stress, after illness, or simply as a result of having lived for too long on convenience foods, so your body has become depleted in essential minerals, trace elements and vitamins. When you have eaten like this, many of your metabolic processes no longer work properly. Then it's time to make some serious changes in the way you are eating, and keep your alcohol intake to a minimum. In the meantime, there are a number of effective plants for heightening your sexual energy: Mucuna Dopa—this is a powerful Ayurvedic herb, also known as velvet herb. A potent extract from the Mucuna pruriens seed, it heightens brain function, libido and muscle growth. It contains high concentrations of L-Dopa, a neurotransmitter which prompts a positive mental state of action and assertiveness. These are a few of the reasons Mucuna Dopa is an effective sexual enhancer for men. Start by taking one 166mg capsule between meals (containing 100mg of L-Dopa). Never take more than 6 a day and do not use if you are taking MAO inhibitors or any prescription drugs without first getting permission from your medical practitioner. Ginkgo biloba—not only boosts the flow of blood to the brain and enhances memory; it can increase circulation to the penis. The best way to take it for this purpose is in the form of a concentrated 24% standardized extract capsule, once or twice a day. Do not take more, since in large quantities gingko can cause loose bowels and irritability. One research project gave men 80 milligrams of gingko extract three times a day, with excellent results. It not only cleared impotence, it lifted the depression which often accompanies it. You can also get a ginkgo tincture: 1 teaspoon in a little water twice a day. Horny goat weed—has been known for 2000 years in traditional Chinese medicine to enhance both male and female libido. It increases blood circulation to the genitals. A study carried out in 2008 indicated that it can be as effective as Viagra but without the dangerous side-effects. One 1 gram tablet daily between meals is the usual recommended dose. Fava beans—can have an astounding effect on an erection. The first written record of this food's sexual benefits comes from ancient Rome, where Cicero used it to increase his own passion. Fava is also a good natural source of L-dopa (used to treat Parkinson's disease). It intensifies erections in many men, which is how fava got its reputation. One way to use fava beans is to make soup from them. See below for my recommendations. Source Naturals, Mucuna Dopa, 100 mg, 120 Capsules http://www.iherb.com/Source-Naturals-Mucuna-Dopa-100-mg-120-Capsules/14235?rcode=yes026 Paradise Herbs, Ginkgo Biloba, 120 Veggie Caps http://www.iherb.com/Paradise-Herbs-Ginkgo-Biloba-120-Veggie-Caps/4244?rcode=yes026 Planetary Herbals, Horny Goat Weed, Full Spectrum, 1,200 mg, 60 Tablets http://www.iherb.com/Planetary-Herbals-Horny-Goat-Weed-Full-Spectrum-1-200-mg-60-Tablets/1561?rcode=yes026 Bob's Red Mill, Fava Beans http://www.iherb.com/bob-s-red-mill-fava-beans-naturally-blanched-skinless-20-oz-567-g/9904?rcode=yes026 Dragon Herbs, Siberian Ginseng, Super Potency Extract http://www.iherb.com/dragon-herbs-siberian-ginseng-super-potency-extract-2-fl-oz-60-ml/22557?rcode=yes026

Sexual impotence—a loss of ability to maintain a full erection—affects most men at some time in their lives. It can be the result of feeling unwelcome, afraid of your own power, or experiencing a sense of inadequacy or depression about yourself. Such feelings strongly influence the behavior of your body. And when you can develop real awareness of how your lover feels, with patience and consideration, psychologically-caused impotence will often clear by itself. Other difficulties in maintaining an erection can be biochemical in nature. In men over the age of 35, this often happens during periods of prolonged stress, after illness, or simply as a result of having lived for too long on convenience foods, so your body has become depleted in essential minerals, trace elements and vitamins. When you have eaten like this, many of your metabolic processes no longer work properly. Then it’s time to make some serious changes in the way you are eating, and keep your alcohol intake to a minimum. In the meantime, there are a number of effective plants for heightening your sexual energy: Mucuna Dop Mucuna Dopa—this is a powerful Ayurvedic herb, also known as velvet herb. A potent extract from the Mucuna pruriens seed, it heightens brain function, libido and muscle growth. It contains high concentrations of L-Dopa, a neurotransmitter which prompts a positive mental state of action and assertiveness. These are a few of the reasons Mucuna Dopa is an effective sexual enhancer for men. Start by taking one 166mg capsule between meals (containing 100mg of L-Dopa). Never take more than 6 a day and do not use if you are taking MAO inhibitors or any prescription drugs without first getting permission from your medical practitioner. Ginkgo biloba Ginkgo biloba—not only boosts the flow of blood to the brain and enhances memory; it can increase circulation to the penis. The best way to take it for this purpose is in the form of a concentrated 24% standardized extract capsule, once or twice a day. Do not take more, since in large quantities gingko can cause loose bowels and irritability. One research project gave men 80 milligrams of gingko extract three times a day, with excellent results. It not only cleared impotence, it lifted the depression which often accompanies it. You can also get a ginkgo tincture: 1 teaspoon in a little water twice a day. Horny goat weed Horny goat weed—has been known for 2000 years in traditional Chinese medicine to enhance both male and female libido. It increases blood circulation to the genitals. A study carried out in 2008 indicated that it can be as effective as Viagra but without the dangerous side-effects. One 1 gram tablet daily between meals is the usual recommended dose. Fava beans Fava beans—can have an astounding effect on an erection. The first written record of this food’s sexual benefits comes from ancient Rome, where Cicero used it to increase his own passion. Fava is also a good natural source of L-dopa (used to treat Parkinson’s disease). It intensifies erections in many men, which is how fava got its reputation. One way to use fava beans is to make soup from them. Whatever products you buy it is essential that they are top quality and organic. Be warned, there are lots of cheap imitations which do not deliver on their promises. See below for my recommendations. Source Naturals, Mucuna Dopa, 100 mg, 120 Capsules Paradise Herbs, Ginkgo Biloba, 120 Veggie Caps Planetary Herbals, Horny Goat Weed, Full Spectrum, 1,200 mg, 60 Tablets Bob's Red Mill, Fava Beans Dragon Herbs, Siberian Ginseng, Super Potency Extract

Sexual impotence—a loss of ability to maintain a full erection—affects most men at some time in their lives. It can be the result of feeling unwelcome, afraid of your own power, or experiencing a sense of inadequacy or depression about yourself. Such feelings strongly influence the behavior of your body. And when you can develop real awareness of how your lover feels, with patience and consideration, psychologically-caused impotence will often clear by itself. Other difficulties in maintaining an erection can be biochemical in nature. In men over the age of 35, this often happens during periods of prolonged stress, after illness, or simply as a result of having lived for too long on convenience foods, so your body has become depleted in essential minerals, trace elements and vitamins. When you have eaten like this, many of your metabolic processes no longer work properly. Then it’s time to make some serious changes in the way you are eating, and keep your alcohol intake to a minimum. In the meantime, there are a number of effective plants for heightening your sexual energy: Mucuna Dop Mucuna Dopa—this is a powerful Ayurvedic herb, also known as velvet herb. A potent extract from the Mucuna pruriens seed, it heightens brain function, libido and muscle growth. It contains high concentrations of L-Dopa, a neurotransmitter which prompts a positive mental state of action and assertiveness. These are a few of the reasons Mucuna Dopa is an effective sexual enhancer for men. Start by taking one 166mg capsule between meals (containing 100mg of L-Dopa). Never take more than 6 a day and do not use if you are taking MAO inhibitors or any prescription drugs without first getting permission from your medical practitioner. Ginkgo biloba Ginkgo biloba—not only boosts the flow of blood to the brain and enhances memory; it can increase circulation to the penis. The best way to take it for this purpose is in the form of a concentrated 24% standardized extract capsule, once or twice a day. Do not take more, since in large quantities gingko can cause loose bowels and irritability. One research project gave men 80 milligrams of gingko extract three times a day, with excellent results. It not only cleared impotence, it lifted the depression which often accompanies it. You can also get a ginkgo tincture: 1 teaspoon in a little water twice a day. Horny goat weed Horny goat weed—has been known for 2000 years in traditional Chinese medicine to enhance both male and female libido. It increases blood circulation to the genitals. A study carried out in 2008 indicated that it can be as effective as Viagra but without the dangerous side-effects. One 1 gram tablet daily between meals is the usual recommended dose. Fava beans Fava beans—can have an astounding effect on an erection. The first written record of this food’s sexual benefits comes from ancient Rome, where Cicero used it to increase his own passion. Fava is also a good natural source of L-dopa (used to treat Parkinson’s disease). It intensifies erections in many men, which is how fava got its reputation. One way to use fava beans is to make soup from them. Whatever products you buy it is essential that they are top quality and organic. Be warned, there are lots of cheap imitations which do not deliver on their promises. See below for my recommendations. Source Naturals, Mucuna Dopa, 100 mg, 120 Capsules Paradise Herbs, Ginkgo Biloba, 120 Veggie Caps Planetary Herbals, Horny Goat Weed, Full Spectrum, 1,200 mg, 60 Tablets Bob's Red Mill, Fava Beans Dragon Herbs, Siberian Ginseng, Super Potency Extract

Thu, 21 Feb 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/15434/ https://edoc.ub.uni-muenchen.de/15434/1/Simakov_Anastasia.pdf Simakov, Anastasia