Podcasts about Stepwise

IdeasLab, the entrepreneurial and innovation hub at University of Galway, has announced the winners of its student entrepreneur Start100 competition. Start100 for University of Galway entrepreneurs Damien Delaney, a first-year Psychology student from Birr, Co Offaly and the owner of Hology Photography secured the top prize and a €5,000 award for his visual-based app called FocusZen which enables individuals to use photography as a form of meditation and a way of enhancing their wellbeing. Final year Bachelor of Commerce student David Garvey from Glenamaddy, Co Galway, received the One to Watch award and a prize fund of €1,000 for Arclo, an innovative clothing brand bringing t-shirts to life using augmented reality technology. Most Engaging Pitch went to Claudine Mulihano, a first-year Podiatric Medicine student from Dundalk, Co Louth, and her idea StepWise, a smart insole designed to tackle the foot condition plantar fasciitis using Bluetooth technology to transmit real-time biomechanics data to healthcare practitioners. Alongside the three main prize winners, one of the Start100 judging panel, Paul Merriman, chief executive of Fairstone, pledged to give student Emily Donellan from Maree, Co Galway €2,000 in funding for her podcast Start Right, a by-student, for-student podcast that offers tailored advice and guidance to young people transitioning from secondary school to college. Start100 offers students an intensive six-week programme, where ten teams refine their business model and present at a special showcase, bringing their innovative business ideas to a panel of judges from the worlds of academia, research, and enterprise. The competitions is designed to empower early-stage student startups. During the process the teams are introduced to speakers from different industries, experts in entrepreneurial development both regionally and nationally, and Start100 alumni who have successfully started their own businesses. Each team is matched with a mentor in a relevant field, ensuring they receive the advice and the support they need to take their idea to the next level. Professor Peter McHugh, University of Galway's Deputy President and Registrar, said: "University of Galway plays an important role in nurturing innovation and growth within our region and beyond. Start100 is an example of how the connections we foster with industry cultivate innovative leadership skills in our students, and provides them with the space and supports to develop ideas with the potential for broader societal impact." Méabh Conaghan, Regional Director for the West and North-West Regions, Enterprise Ireland, said: "Programmes that encourage and support student entrepreneurship at all levels are crucial to a vibrant start-up ecosystem. The Start100 series of incubation supports is to be applauded as it helps students to explore, develop and validate their ideas in a structured and safe environment. Enterprise Ireland West region is delighted to collaborate with Ollscoil na Gaillimhe and its IdeasLab team on Start100 2024. Enterprise Ireland warmly welcomes Start100, recognizing it as an avenue for future enterprise success and is happy to support this worthwhile initiative." Throughout the programme students visited CREW, ComWorks in Loughrea, Platfrom 94 and the Portershed and had guest speakers from Enterprise Ireland, Westbic, the Local Enterprise Office (LEO) and Start100 alumni. They were given workshops on intellectual property, tax, presentation skills and more, and speakers from successful enterprises such as Mbryonics and Tribe Hospitality. The judging panel for the final event were Dr Helen McBreen, Partner Atlantic Bridge; Paul Merriman, CEO Fairstone; Méabh Conaghan, Regional Director for the West and North-West Regions, Enterprise Ireland; and John Brennan, CEO WestBic, and the prize fund sponsored by AskPaul for the second year in a row. Dr Natalie Walsh, Director of Entrepreneurial Development at University of Galway, said: "Start100...

This episode on neurogenic bowel explores the stepwise approach for bowel management. From treatment options, age group considerations, adapting for cognitive differences, and support, we'll address it all with Dr Mandy Rounds and Nurse Practitioner Dr. Maryellen Kelly. Resource:https://www.spinabifidaassociation.org/lifespan-bowel-management-protocol/

Transcription Notes “Upili program”? Yes and it isn't even a misspelling. Our guest, Carla Birnberg will tell us all about Upili, where it comes from and what it is. Carla started life in Pittsburg, but nearly thirty years ago she ended up in Austin, TX. Prior to Austin she worked in North Carolina where she owned her own personal trainer business. She sold that company when she moved to Austin which was due to marriage. Carla has always been quite the storyteller. Her Bachelors degree was in English Literature, but her mom convinced her to go to graduate school where she earned a Master's degree in Educational Counseling. After her move to Austin she became a successful blogger and internet writer for a number of major brands. Four years ago she, as she would say, pivoted to working with the Next Step Foundation to help persons with disabilities in East Africa. We have quite the informative and interesting conversations about disabilities and how they are viewed in Kenya as opposed to the United States. Carla makes a strong case for why in reality the treatment of persons with disabilities between the two countries is not too different although in Kenya possibly the treatment of people with disabilities there is more visibly negative. Carla does say overall the views of us are pretty similar. While you may hear some things discussed that have come up in other episodes of Unstoppable Mindset I think you will discover in Carla a person with a wealth of knowledge. Among other things, she describes how in Kenya where the Upili program is used, counselors with disabilities are brough into schools and organizations so the people there see good models to enrich and inspire them. This was a fun and wonderful conversation. I hope you enjoy it. About the Guest: Carla has dedicated her professional journey to cultivating connections, whether between individuals, places, or concepts. As a passionate advocate for amplifying the voices of marginalized communities, she most recently wove together her gift for ethical storytelling, her passion for uplifting others, and her academic experience/Master's degree in Educational Counseling to create the Upili program. Upili, Kiswahili for secondary as in secondary schools, engages Counselors with Disabilities to provide group therapy for Students with Disabilities in Kenyan “special schools.” (In Kenya, Students with Disabilities are educated at “special schools” according to their disability, e.g., schools for the blind, schools for the deaf, etc.) Youth with Disabilities are 10 times more likely to suffer from depression, especially in East Africa where stigmatization, marginalization and discrimination are still prevalent. The lack of early intervention of essential psychosocial support creates additional barriers that keep Persons with Disabilities from being able to obtain and maintain meaningful employment. Next Step Foundation's Upili Program addresses this pervasive mental health challenge by providing support for secondary school Students with Disabilities, their families, and communities. By meeting the psychosocial needs of students, training teachers, staff and peers to serve as “psychological first responders,” and offering support to parents and caregivers the Upili Program instills self-confidence, improves academic performance and provides the tools to successfully navigate future discrimination so that Youth with Disabilities can achieve economic independence. In her recent role as the Chief Culture and Inclusion Officer at Stepwise Inc., Carla played a pivotal role in advancing impact sourcing initiatives. Stepwise, a frontrunner in the impact sourcing movement and the first B Corp certified company in East Africa, benefited from Carla's leadership in leveraging AI technology to empower marginalized groups, particularly individuals with disabilities and young women, enabling their full participation in the digital economy. Driven by a commitment to fostering a positive organizational culture, Carla has created initiatives aimed at enhancing employee retention amidst Stepwise's rapid growth. Her innovative approaches, including "stay interviews," upskilling opportunities, and mentorship programs, have infused the company's core values into daily operations, cultivating a workplace where employees are not only motivated to come to work but also eager to remain with the organization, even across vast distances. As a collaborative leader Carla has developed and implemented comprehensive training and support programs for cultural integration within organizations undergoing expansion through acquisitions. Her approach, which includes individual and group coaching as well as fostering cultural sensitivity, has proven instrumental in navigating organizational transitions. Carla's earlier career in marketing showcased her aptitude for connecting communities, influencers, and brands. With a track record of success in developing innovative branding and marketing campaigns, she has left an indelible mark on the industry. Her pioneering use of omni-channel media, blending lifestyle with product placement alongside esteemed personalities and leading brands such as Venus Williams, FILA, and Walt Disney World, made her a trailblazer in the realm we now simply refer to as 'influencers. Ways to connect with Carla: Next Step Foundation website https://nextstepfdn.org/ Upili Program website https://www.upili.org/ Upil Instagram https://www.instagram.com/upili_program? Upili Twitter https://twitter.com/upiliprogram? Carla Birnberg Substack https://carlabirnberg.substack.com/ About the Host: Michael Hingson is a New York Times best-selling author, international lecturer, and Chief Vision Officer for accessiBe. Michael, blind since birth, survived the 9/11 attacks with the help of his guide dog Roselle. This story is the subject of his best-selling book, Thunder Dog. Michael gives over 100 presentations around the world each year speaking to influential groups such as Exxon Mobile, AT&T, Federal Express, Scripps College, Rutgers University, Children's Hospital, and the American Red Cross just to name a few. He is Ambassador for the National Braille Literacy Campaign for the National Federation of the Blind and also serves as Ambassador for the American Humane Association's 2012 Hero Dog Awards. https://michaelhingson.com https://www.facebook.com/michael.hingson.author.speaker/ https://twitter.com/mhingson https://www.youtube.com/user/mhingson https://www.linkedin.com/in/michaelhingson/ accessiBe Links https://accessibe.com/ https://www.youtube.com/c/accessiBe https://www.linkedin.com/company/accessibe/mycompany/ https://www.facebook.com/accessibe/ Thanks for listening! Thanks so much for listening to our podcast! If you enjoyed this episode and think that others could benefit from listening, please share it using the social media buttons on this page. Do you have some feedback or questions about this episode? Leave a comment in the section below! Subscribe to the podcast If you would like to get automatic updates of new podcast episodes, you can subscribe to the podcast on Apple Podcasts or Stitcher. You can also subscribe in your favorite podcast app. Leave us an Apple Podcasts review Ratings and reviews from our listeners are extremely valuable to us and greatly appreciated. They help our podcast rank higher on Apple Podcasts, which exposes our show to more awesome listeners like you. If you have a minute, please leave an honest review on Apple Podcasts. Transcription Notes: Michael Hingson ** 00:00 Access Cast and accessiBe Initiative presents Unstoppable Mindset. The podcast where inclusion, diversity and the unexpected meet. Hi, I'm Michael Hingson, Chief Vision Officer for accessiBe and the author of the number one New York Times bestselling book, Thunder dog, the story of a blind man, his guide dog and the triumph of trust. Thanks for joining me on my podcast as we explore our own blinding fears of inclusion unacceptance and our resistance to change. We will discover the idea that no matter the situation, or the people we encounter, our own fears, and prejudices often are our strongest barriers to moving forward. The unstoppable mindset podcast is sponsored by accessiBe, that's a c c e s s i capital B e. Visit www.accessibe.com to learn how you can make your website accessible for persons with disabilities. And to help make the internet fully inclusive by the year 2025. Glad you dropped by we're happy to meet you and to have you here with us.   Michael Hingson ** 01:20 Well, hello, and welcome to another episode of unstoppable mindset. Our guest today, my partner in conversation that is Carla Birnberg. Carla has a really interesting story to tell. She lives in Austin. And I don't know where else in the US she's live. But we'll find out because we'll drill down and, and get it out of her. But she spends her waking hours thinking of and assisting people, especially children with disabilities in Kenya, and helping them to become more accepted, which makes a lot of sense. And of course, needless to say, that's near and dear to my heart. And we will we will get to all that as we go through our discussions. But for now, Carla, I want to welcome you into unstoppable mindset. And thank you very much for being here. Thank   Carla Birnberg ** 02:14 you so much for having me. I know it took a beat for us to get the date together. And I'm so glad to be here.   Michael Hingson ** 02:21 Well, we made it happen, which is really good. There you go. Tell us about the early Carla growing up and stuff like that.   Carla Birnberg ** 02:29 The early Carla   Michael Hingson ** 02:31 Yeah, gotta hear about the early Carla.   Carla Birnberg ** 02:34 I laughed because I've been thinking a lot. You know, that question that career counselors and coaches ask you What did you dream of being when you were little? And I don't know. This will date me that book Harriet the Spy. You're a man you might not be familiar with more of The Girl type read. But Harriet walked around her neighborhood pretending she was a spy with a notebook writing everything down. And I kind of think that my current career as chief storyteller, I've achieved it. And there were some deviations along the way. But my whole life that's really been it, listening to stories and amplifying what other people are doing.   Michael Hingson ** 03:15 Carla the spy no doubt about it.   Carla Birnberg ** 03:17 I know maybe they can make it into a movie.   Michael Hingson ** 03:20 Well, why not? Now who played Harriet? I'm trying to remember was it?   03:27 I can't remember her. Donal, I think she was. I think it was Rosie O'Donnell.   Carla Birnberg ** 03:32 I think you're right. I'd forgotten. I don't know where   Michael Hingson ** 03:34 she was Harriet, or she was the mother but she was in there with the mom   Carla Birnberg ** 03:38 she was. And that was I mean, I can really remember walking down my street. It's a kid with that notebook and the pencil. And I hadn't thought until right now. So thank you about how far I've come and how not far.   Michael Hingson ** 03:54 So now no pencils, keyboards. I   Carla Birnberg ** 03:57 know keyboards, voice notes and our phone all of it.   Michael Hingson ** 04:01 So you, you absorb stories and all that and tell me a little bit more about you and growing up and all that.   Carla Birnberg ** 04:10 I was pretty theatrical. I did a lot of television work when I was younger. And I thought for about three minutes that I wanted to be on air talent and I interned at our CBS affiliate and then I quickly realized that wasn't my gift. Again, it goes back to I didn't want to be on the screen like you. I wanted to be more behind the scenes writing the stories ended up in college for English English literature, small liberal arts school in Ohio where there was not much else to do but read. And I kind of stayed on this books and storytelling and marketing path my whole life.   Michael Hingson ** 04:51 Now, where are you from? Originally?   Carla Birnberg ** 04:55 Pittsburgh, Pennsylvania. Shout out to the Steelers. Yes, I'm a Pittsburgh girl at heart, even though I've not lived there and maybe 30 years.   Michael Hingson ** 05:04 Oh, that's okay. There are people in New York who say the Dodgers will someday move back to Brooklyn and stinky white. Sure that's going to happen. Of course now with Shohei Otani, I don't think they can afford to move back to Brooklyn. So that's another story. But yeah, but you never know. It isn't gonna happen. They're gonna stay out here. But anyway, that's cool. So you, you, you love to be creative. I interviewed. Well, I keep saying that I shouldn't. I had a conversation with a gentleman yesterday. And his name is Wolf born, he changed his name to wolf born, his middle name was born. In honor of his father, Max Born who was a very famous physicist. He had the name of wolf. He was a nickname, his original name was Randall, Born ready for this? Newton John. He's, he's in Australia. So who do you think so? Who do you think his aunt was?   Carla Birnberg ** 06:11 Olivia? This thing now, I loved Olivia Newton John's talk   Michael Hingson ** 06:17 about a guy who comes from a really creative family. And he, he's, he's, he calls himself a corporate shaman, because he really wants to help organizations and people, people especially move closer to nature and understand that nature has a lot to it can do to guide us and teach us and, and so he really is heavily involved in that. But that   Carla Birnberg ** 06:43 is fascinating. And I'm, I'm with him in terms of, I'm not myself, this is why I don't move back to Pennsylvania. Because of the cold. I need to be immersed in nature every day, preferably barefoot in the grass. It helps me ground myself, so I can show up for other people. He   Michael Hingson ** 07:02 would say, though, that there is time to deal with cold as well, because we we race around so much that we're we way too hot. And so the result is that we don't really deal with nature. We don't tune into nature, which goes in cycles. And we ought to do more of that.   Carla Birnberg ** 07:20 Oh, I'm such a believer. And I just kind of emerged from wintering with Michael, I thought I invented but clearly I did not. When we fall back to we spring forward, I really tried to get still and plan for what's coming next both at work and personally.   Michael Hingson ** 07:41 Yeah, well, I, I learned a long time ago that I'm not going to worry about spring ahead and falling back. Frankly, what I do is go to bed an hour earlier when it is spring. And that way, I come right out adjusted to the time anyway. And as far as falling back, I won't stay up an hour later. I like to get the extra hour asleep. So I'm good. And   Carla Birnberg ** 08:11 you know, that is I think the Kenyan my team. That's the biggest that's the most challenging time of year when we fall back. I'm further so when I'm it's 8am. For me, they're done. It's 5pm for them. I like when we spring forward, because I get that extra hour where they're in the office, they have to adjust a lot to my USA schedule.   Michael Hingson ** 08:34 Yeah, well, I do a lot of work, of course, with excessive B. And the thing about excessive B is that they just switched yesterday night, I guess to daylight saving time. Oh. So they've so it's been a challenge because some of the scheduling hasn't always been coordinated very well. Microsoft hasn't really done some of the things that it was supposed to do.   Carla Birnberg ** 09:09 So I can guess that night before the Sunday before the first Monday after we sprung forward. I was like Carla, you've been doing this for years, but let's focus. Okay, so 8am Do we need to switch this out? Look didn't change the meeting time. Like you said, it's on us.   09:24 Yeah, literally cope. We did.   Carla Birnberg ** 09:28 That's because we're resilient and we're creative.   Michael Hingson ** 09:30 So what did you do once you left college? Well, I'm before you said your degree in college was what in right in writing English English literature. Yeah,   Carla Birnberg ** 09:42 you know, it seemed like a really good idea. I have a daughter who's 18 and my liberal arts degree has been great for cocktail conversation, and it's a lovely degree, but I wasn't really ready to do much after with it after graduation. So I as one does work In an outdoor store, I loved climbing and hiking, and I worked there probably for a year. And my mother, God bless her Jewish intellectual parents came into the store one day and said, Guess what? You're going to graduate school. Now, I'm not paying for this, but it's time to get doing something else. And so I got my master's degree in Educational Counseling. Okay, I use it every day. And I don't use it at all. It's one of those, it's been very helpful, but I've not used it in a traditional fashion.   Michael Hingson ** 10:31 Fair. I understand and empathize a lot, I got my bachelor's and master's degrees in physics. But wow, circumstances, ended up having me go in different directions. But I would never regret the times. And all that I learned in physics, the details, the kinds of things I learned some of the more basic life lessons like pay attention to details that are so important. And there's some examples of that in terms of why it's important in physics. But for me, I took it more to heart in a general way. And really work to pay attention to details, more of us ought to do that and observe what goes on around us, and learn to recognize what is working, what's not working, do really pay attention to the details to find out if the details are going the way we expect. And if they're not, why not? Because it might very well be that they have something to teach us. That's   Carla Birnberg ** 11:30 a really, phenomenally interesting takeaway from a physics degree I wouldn't have thought of. And you're right. That's a skill we all need. Because we need to know when to pivot when to change what we're doing. And if we're going too fast, we don't even notice. Right?   Michael Hingson ** 11:47 So you've got a master's in education. Yeah.   Carla Birnberg ** 11:53 And then what, and then I moved for a job, I was very excited, I packed up my car, I'm going to Chapel Hill, North Carolina for a job, I get to Chapel Hill, and welcome, but there's no job anymore. So again, if it and this kind of took me, I don't really believe we get off our path because everything comes together. But I ended up becoming and if you knew me in my childhood, this shocks, everybody actually straight up through college, a personal trainer, and not athletic at all. And I ended up opening a personal training studio, but with that using them it was master's in education with an emphasis on counseling. So those counseling skills, yes, I did need the fitness knowledge. But the counseling skills really helped make me successful as a personal trainer. And then I sold my training studio moved to Austin, and became a big online, personal brand all sort of by accident.   Michael Hingson ** 12:56 Why personal trainer, what what got you to do that?   Carla Birnberg ** 13:02 Back then I probably would have said because I love paying my rent and my bills. And it seemed like something I could do to make some money. But I know myself and what comes easy to me, I'm not a good teacher of I could never have taught the clarinet came very easy to me. I could have taught math because I struggled with it. I'm not naturally someone who's very adept with fitness, terrible hand eye coordination. And yet I knew when I started lifting weights briefly in college, for women, leaving much more than men, it's where we can find our voice. It's where we can discover our power. And so after that happened for me, I kind of wanted to proselytize or evangelize and share that with girls, mostly University of Chapel Hill, undergrads and women in the area. I believe in it's so much teaching us to be strong and take up space and speak up. It's really where I found my voice.   Michael Hingson ** 14:05 Why didn't you stay with it, though? You sold it eventually and move to Austin,   Carla Birnberg ** 14:09 sold it and move to Austin and no more brick and mortar for me ever. I mean, I   Carla Birnberg ** 14:18 it was great. But   Carla Birnberg ** 14:22 I knew there was a way and I figured it out sort of with another with group of. We call ourselves the OG bloggers across the United States. How could we give away what we were passionate about what our knowledge was in what our skill set was really for free on the internet. So I was working at the Austin American Statesman by day writing features working in their education department, and a blogger by night until the blogging by night got so big that I left the statesman and made that full time.   Michael Hingson ** 14:55 Ended up getting out of the newspaper business. none   Carla Birnberg ** 14:58 too soon to my chagrin. I mean, I'm sad that it's kind of dying off. Yeah.   Michael Hingson ** 15:03 Yeah, I think it'll be a sad day if we lose newspapers. I   Carla Birnberg ** 15:10 absolutely agree. I mean, that's some of my best memories of being a family growing up this Sunday, New York Times the local Pittsburgh paper.   Michael Hingson ** 15:21 So, you, you really got into blogging and what were you blogging about? Or what were you doing?   Carla Birnberg ** 15:29 It's that master's degree. It was personal development and fitness, but not prescriptive, not go to the gym and lift this weight and do it this way. It was more, what's your language of encouragement? A few iterations back? What's your why? How do we get to the gym? How do we commit to fitness? How do we figure out why this is even important to us so we can achieve the goals that we've set for ourselves. Okay,   Michael Hingson ** 15:55 well, going back even a little bit further and deeper. Why Austin? Ah, this   Carla Birnberg ** 16:01 marriage came down. Yes. And you know, it is I love the city. It's changed a lot. But I'm still not one of those. And there are many of them now. Just old Austin was better. And as we've grown, it's changed. And I love it just as much. I've been here 24 years. Long time. Hmm. Yes. And I have no plans to leave yet until unless they priced me out, then maybe?   Michael Hingson ** 16:26 Well, so. So you got into blogging and all that. And that's a good thing. But as you pointed out, needing incomes and so on, so how did all that work for you?   Carla Birnberg ** 16:44 So Well, I mean, I gratitude. There's I read somewhere once and I'm sure someone famous said it, and I should quote them, but I can't remember who if you woke up tomorrow with only what you were grateful for today. What would that look like? And I have such a gratitude practice kind of framed around that. And I was very lucky financially with the blogging got in at the beginning worked with some big big names Phila Birkenstock Wonderful Pistachios, Sears, who I think is no more worked with Venus Williams and really made it into a lucrative and enjoyable and impactful I could help people career until everyone became an influencer. And I read that landscape and thought it might be time to get out.   Michael Hingson ** 17:36 So the idea was, they were sort of sponsoring you, or they were paying you to write blogs for them. That's   Carla Birnberg ** 17:42 it, you know, they would come I mean, this was back in Paleozoic Era, like 2006. Let's say when I started, they would come with Okay, we have $35,000, what can you do for us? How many videos how many posts? Will you write, and we can put it on our website, Sears Venus Williams Birkenstock? Can you do print advertisement for us, though it was before everyone was an influencer? Where I get it. If I were the brand, I would think I'm going to pay 50 Different UT students $50 Each and see what I get versus these big paychecks to the original influencers? Yeah.   Michael Hingson ** 18:24 So you did that. And, and again, at some point, it sounds like you pivoted into what?   Carla Birnberg ** 18:34 Wow, let's go back to March 2020. It was before then that I read the landscape. You know, I had some podcasts that I hosted. So I know how hard you work. And I had written a book. And at that point, I was working with Venus. She blurbed, the cover of my book, and I thought, Where do I go from here? I was doing LIVESTRONG with a big website at the time, some content creation for them. And I was just in that moment of what should my next be when the world sort of started looking like it was changing. I had already been in conversations with a startup in Austin and Nairobi about doing some marketing for them, potentially just fractional short term CMO. And I thought I don't know what's happening here. COVID And I'm gonna do this because I don't think it's the time to work the gig economy even though I don't know what's happening. And I mean, again, gratitude said yes, took the leap had never done anything like this. I'd done the marketing I'd never worked globally and just thought, I'm gonna give this a shot. And I mean, it is no understatement to say it is the best Yes, I've ever said second to working with dentists. It's the best death I've ever said.   Michael Hingson ** 19:50 Why is that?   Carla Birnberg ** 19:54 It has changed my life. I mean, I traveled a lot as a child. My dad was a professor So he would take his sabbatical in. He did it twice in London. So I lived in Oxford and I've been exposed to the world but not, not in this consistent way. And the backdrop of my entire life I'm Jewish, but I'm not religious is Tikun Olam, which means repair the world. And really, it's we can't fix everything. So let's take our little tiny corner and try to fix it up as best we can. And I'd watched my parents do that. And I done some volunteering, but this global experience and given me an opportunity to really take my gifts and use them in a different way and meet so many different people. And it's just shifted my life perspective. And I'm so grateful.   Michael Hingson ** 20:48 Well, yeah, so tell me more about kind of what you did and what you're doing. Now. I'm assuming it's all related.   Carla Birnberg ** 20:57 It is the short version with the startup as with many startups, our whole goal was to eventually have the entire C suite team moved to Kenya, after about two and a half years. That's what happened. And I can tell you, I could have looked for a totally different job at that point, not gotten up at four in the morning. But gratitude spiritual practice, I just really felt that my work in Africa wasn't done. And I shifted to our foundation and became I was the head of culture and inclusion with the for profit startup, and moved kind of back to marketing on some level and became the chief storyteller, for next step Foundation.   Michael Hingson ** 21:44 And the next step foundation. Sounds pretty fascinating. Tell me more about that, if you would,   Carla Birnberg ** 21:49 we focus on helping the historically and it gets back to semantics, you and I had a really great pre interview chat about that the historically excluded I now do not love the word marginalized, mostly from my, my project persons with disabilities, but the whole foundation, it's women and youth and persons with disabilities by we recruit them, we assess what they need, we accommodate whatever their needs are. Maybe this is a young woman who has no digital skills, maybe this young man needs a screen reader. And then we train them. And unlike many nonprofits in the Global South, we don't just train, we then transition them into the job and support them in the job, after mentorship, kind of making sure that they have everything they need, so that they can be successful and feel successful. It's not all about the career. It's also about feeling really good about the work that they're doing.   Michael Hingson ** 22:55 So where does the next step foundation function primarily?   Carla Birnberg ** 22:59 It is mainly in Nairobi. So it's yes, it's been a big shift, when I was with the for profit entity, there are probably 17 of us in the States. Now there to go around noon, it can feel like a ghost town. I love my team, because they'll stay up late for me. But mostly in Nairobi, we have a small office here.   Michael Hingson ** 23:26 And so tell me a little bit more about about what you do. And we definitely can have the discussion here that we had ahead of time. And I'll let you kind of lead that as to where you'd like it to go. But tell me a little bit more about what what you actually do now and and kind of how all that works.   Carla Birnberg ** 23:46 I'm so it's such perfect timing for us to talk. You know, I started chief storyteller, this is great. I got to help with some marketing language. That was fun. And my favorite aspect of the job, which is not my new project is helping to create the impact narratives of our participants. Because I mean, it's almost like a puzzle where I interview them. And then I get snippets half of the time, it's in Swahili, so I pull in other team members to translate and kind of get that opportunity to weave it into a story. And our focus at the foundation is ethical storytelling. I have nothing to do with the story. My perspective doesn't matter. And in addition to that, and I know that the participants and people with whom I've worked at Next Step sort of chuckle, but we always ask for vigorous and consistent consent. So if I write a fantasy story, and he says, yep, here's my story. Yes, he's my picture. He approves everything. I put it on LinkedIn. And then I want to share it on Twitter. I'm going back to him, because it's really important to us as a foundation and me as chief storage Heller, at any time, a Fontas could say, You know what, I'm kind of over it. I don't want you to share my story anymore of going from x and acquiring my disability and then doing this and getting this job. And we would say, okay, so I love that facet of my job, the storyteller, and yet I had a little gap of time. And that's how this new project was created. The one that you and I have spoken about. And can I transition into that? Yes, you are excited. Okay. It's, I'm so thrilled we just finished our pilot program. It's called oo p li, which means secondary and key Swahili.   Michael Hingson ** 25:39 And how do you spell that? Up?   Carla Birnberg ** 25:41 i Li. Okay, great. I know I actually had on my appealing necklace. And then I've no idea why I thought I would be a grown up and take it off. Because I'd like to wear it in the community. So people say, hey, Carla, actually, I have a keychain. They'll say, hey, Carla, what is your necklace? What is your pili? And then I whip out my keychain, Michael with the QR code on the back. And I'm like, Thank you for asking, here's the website and how you can give me money. very appealing means secondary. And we thought I thought, wouldn't it be amazing if we went into these special schools in Kenya, which is their way of defining the schools that are created only for persons with disabilities, typically, very segregated schools for the blind schools for the deaf, there are some which are for all disabilities. And there are some which they also call integrated, which means for people who do not have a disability and those with disabilities, the plan was to go into these schools and meet material needs, build perimeter walls, give them new desks, supply hot water heaters, things that are very important and that I thought, this is the answer we went to visit. And I suddenly it dawned on the entire team. This is great, giving physical items. But this is all for something many, many NGOs are already doing. They'll come in, every Oprah gets a new desk, they'll come in, we will paint and build new hospitals, what we would call dormitories. So I met with our team who went to joy town, this is where we did our pilot there all the antics, persons with disabilities and said, Okay, a lot of people are meeting this need for the physical items. What else is in need? That is even more pressing. And this is when the conversation began around what I was aware of, I thought through doing the impact storytelling, I was not aware of the deep degree. And we started talking about the stigma around being a person with a disability and Kenya, the stigma from childhood, the discrimination as they grew older, and the more we talk as a team, the more we realized, it's therapy. It's counselors with disabilities going into these special schools, and doing group therapy with students with disabilities to give them that psychosocial support needed, filling the gaps with what they might already be getting at school. So they build their self confidence. So when they graduate, and finally graduate, I know I'm excited, an equal rate as their non disabled peers, they can thrive, they can get their jobs because they process this past trauma.   Michael Hingson ** 28:50 So in general, how our disability is treated in Kenya, as opposed to in the US or in East Africa in general, how are how are they treated differently? Or are they treated differently? Or do you think that there are a lot of similarities? I   Carla Birnberg ** 29:06 would be the first to say that I am not. I'm, as not evidenced in this moment. I'm a listener more than a talker. So I've had an interesting conversation about this with friends with disabilities in the States. I would still say that the stigma is tremendous. We've come a little bit further here. I've written the stories of a lot of my team members and the pressure on their parents after they were born to leave the baby at the hospital to euthanize the baby. Because there's still that fear in the villages not so much in Nairobi, that the child has a curse. The family is now curse. They hide the children away frequently. I remember one student was talking about how her mother had tried to To kill her, and the assumption I came from was, Oh, that's very sad, you know, she was a baby, and she was probably 13 or 14, no, this had happened last spring break from school, there's so much shame and fear that I just don't see here.   Michael Hingson ** 30:21 Or at least hear, it may be covered up more, but there's still a lot of it. We still hear of, oh, say blind parents who want to who have a child, and the courts want to take them the child away, or their ballot battles around that, or parents who just shelter their children with disabilities and don't let them explore. So I had to write, I think, I think it may be that, that the hiding is more sophisticated in some ways. But I think to a very large degree, it's still there. And I think that it is because of what you said, it's the fear. And what we don't realize collectively, as a society, is that disability shouldn't mean a lack of ability, as, as I tell people, and then they say, well, but disability starts with dis. And I said, Yeah, and so does disciple, and so does discern. So what are you saying? You know, the the fact is that dis isn't the issue. It's the perception, it's the fear. It's the prejudice, that we all need to overcome, and get to the point where we truly recognize that what disability is, is a characteristic that every single person has, except that it manifests itself differently for different people.   Carla Birnberg ** 31:53 Yes, I mean, my past four and a half years have been like a PhD, and I don't know what it would be, but I have been so educated by my team. And what you said made me think of a couple of things. One is my go to I couldn't do anything without her. Mariam and degla. She's my up Lee everything campus liaison. She has said repeatedly, you know, my parents she has cerebral palsy hadn't just been her mother and her grandmother, go, you're like any other child? No, we're not going to make accommodations for you, she said always says to me, I would not have come as far as they didn't shelter me. And that she credits that to her success in life.   Michael Hingson ** 32:38 Yeah, and actually, there are differences between accommodations. And yes, you're right sheltering. But I know what you're saying. And the reality is that we we make accommodations for sighted people all the time, right? We have lights in our buildings so that people can see where to walk, we have your right, we have a coffee machine so that people can get coffee or tea or hot chocolate or something, even though it's touchscreen nowadays, so it's not even accessible for everyone. We have so many different things that we offer. But we like it to be more one sided. We don't recognize that those are just as much accommodations as providing a screen reader for providing a ramp.   Carla Birnberg ** 33:27 And curb cut effect I had not heard of until four years ago. We use them all the time, the captions, all of it. And yet we avail ourselves of things that aren't created for us.   Michael Hingson ** 33:42 Right? The reality is that we all have gifts, and we all have things that we don't do as well as other people. And it is it is so unfortunate that we haven't even in this country taken the leap to really understand that.   Carla Birnberg ** 34:04 No, and I think I see that much more clearly. Now, I see that much more clearly not doing the work in East Africa. I do. You know, I think and I was thinking about this earlier, and I almost reached out to you by email, and then I thought now you're such a brilliant man, I'm gonna corner you And wouldn't you think that our therapists so we always use counselors with disabilities, first of all, so that the students see the counselor and think that's pretty amazing. I could do that. I had never I didn't dream that was possible. But also they have shared lived experience. If we'd had a counselor, even Kenyan go into his run this group therapy group who didn't have a disability, they would waste two or three sessions trying to explain to him or her, this is what it's like being me in Kenya. So he went in and thought okay, we are going to To practice affirmations using a mirror, this is going to be very interesting, the students might need some help bolstering their self esteem and coming up with the affirmations. I'm on it. She was surprised. And again, woman with a disability, that most of the students in therapy groups were completely unable to look in the mirror, because they had kind of integrated all of the negativity that had come at them from their families from the village. They couldn't even look at themselves in the mirror. And even she was shocked by that. And I'm really curious, your thoughts on is that unique to Kenya and that vast amount of negativity and stigma around having a disability? Or do you think that might be paralleled in the USA?   Michael Hingson ** 35:47 Well, I think there is a fair amount of it in the USA. I've not heard of anybody who said that they can't look at themselves in the middle. Except for vampires, but. But I do seriously think that there are a lot of similarities. So I've told the story a few times on unstoppable mindset. But I did a talk a few years ago, it was a hybrid talk. And I talked about disabilities. And I talked about the fact that for blind people. In reality, the term visually impaired is one of the most disgusting things that people can say to describe us, even though it's what the so called experts in the field created years ago, but visually impaired is a problem for a couple of reasons. One, visually, we're not different simply because we're blind to lose your eyesight, it doesn't mean that you're visually different. So that's a problem. But the bigger issue is impaired. Why am I being at all compared with person with eyesight? Why is it that I have to be considered impaired simply because I don't see if you want to talk about vision? I think I got lots of vision, I just don't see good. Like, I'd love to tell people. Don't I talk? Well, anyway. So I think that the term visually impaired is a problem. And I mentioned that in my talk. And I also said, the better terminology is blind and low vision. A lot of people hate blind, but you know what, that's what I am. And I happen to be physically blind. And there are a lot of idiots out there who are mentally blind, and we won't go there.   Carla Birnberg ** 37:30 We won't go encountered a lot.   Michael Hingson ** 37:32 But But anyway, so the the issue with the talk is I gave this talk. And then I opened it for questions. And people could in the audience, ask questions, or people could call in and this one woman called in, and she said, I am visually impaired. And that's all there is to it. And I said, No, you're not, you're blind. No, I have I just I have some eyesight, then you're low vision. No, I'm visually impaired. See, the problem is all too often we buy into it. And we don't understand how that kind of language continuing to be promulgated around, contributes to the view that people have about us. I love that phrase buy   Carla Birnberg ** 38:18 into it. That's it, I   Michael Hingson ** 38:20 am not impaired. And if I'm going to talk about being impaired, even though your disability is covered up so much, because you have access to electric lights, just have a power failure and see what you do, you immediately look for a smartphone or a flashlight so that you can get light back, because Thomas Edison invented the electric light bulb for you. You like dependent people. But the bottom line is it still is only covering up your disability. Disability is a characteristic that we all have every single person on the planet. And it only manifests itself differently depending on what your gifts are and what your gifts are not.   Carla Birnberg ** 39:03 Okay, super interesting. And well, I'm sure I should have thought about this. But 54 and a half, I hadn't really thought about it much because I've never broken anything. And I'm just getting to this point. But again, Mary and my right hand woman will frequently say, in high school, I advocated for youth students with disabilities and people who had temporary disabilities. And that's a pretty big refrain from her. And the more she said it the more I've thought, oh, yeah, everyone is going to experience some sort of something, whether it's breaking your leg, whether it's becoming low vision, better phrase,   Michael Hingson ** 39:44 or, or whether you suddenly lose power and you can't see what you're doing. And that's my point. Yeah, no, that's my point is that the reality is the disability is there anyway. Yeah, but we do work. And right At least so to offset disabilities that limit us like a lack of light, it's okay, I have no problem with the fact that we have light bulbs, we have so many different mechanisms and ways of producing light for people. But be honest with yourself, it still is a disability, because the time can come when you don't have access to it, the time can come that a person who happens to be blind, might be somewhere and not have access to information that we would like to have access to and ought to have access to. Yeah, and only over more time, will society recognize that it has to provide information to us in in ways that work for everyone, I have a favorite example, I'm not gonna really not be able to describe this very well. But I'm going to try. There's a TV commercial that goes on out here. And the commercial starts out with this woman saying, you know, dad had this. And I don't want you to get it either. You have to really take care of yourself and take care of this right now. Because if you don't, it is going to run your life. And I know that you're one of these, you don't really like anyone telling you what to do. Well, that's the end of the commercial. And I don't know what goes on. There is absolutely nothing. And I don't know whether you've seen that commercial earlier. But there is nothing that says what that commercial is about. Now, someone this morning, I talked with someone who told me that it has to do with some sort of medical thing. And but But even she couldn't remember exactly what it was because there is not a single verbal cue in that commercial telling you what it's about. Much less making it accessible to be Yeah, yeah. And the reality is that, as we all know, many times people don't sit in front of their TV during commercials, they look away or they get up and they go to the bathroom or whatever. It is such a poorly designed commercial because of that. And, and it's unfortunate. But somebody figured, well, we don't need to worry about it other than people being able to see it, and they'll see it and they'll get it. No, they won't. Because it's all too often that people don't watch the screen. And as I said this morning, the person I asked who I regard as an extremely observant person couldn't even tell me what company that commercial was about.   Carla Birnberg ** 42:45 Oh, interesting. And you're right, the world's not, it's not set up accessively. In many instances, it's   Michael Hingson ** 42:53 not set up. Well, accessively or inclusively, we are much less inclusive than we ought to be that commercial could have been created in a much different way to provide information to everyone. But they didn't. And it's so unfortunate. So it shows in some senses, although I think we've made progress in this country. It also shows how far we have not come because that kind of thing still exists.   43:26 Yes. Yes.   Carla Birnberg ** 43:29 I mean, I've thought so much about this, since we set the date for the podcast and just every day at work that my perspective doesn't matter. It's been interesting to me to see. There's a feels like there's a big differential as far as the trauma, outgrowth of being a person with disability. But other than that, that's really the only major difference. And that's what made us think, okay, we need to focus on mitigating this trauma so that the students can be successful.   Michael Hingson ** 44:00 Well, there's a lot of merit to having role models. And when you bring people in, who are true role models, it makes a lot of sense to do that. And I think there's a lot of precedent for that. So having counselors having people who come from the same kind of environment that they come from, is very relevant. I spoke in Japan, back in 2012. Well, it was the publisher of thunder dog. My book in Japanese brought me over for two weeks. And one of the things that I learned there was that if you are a blind person, I don't know if it's changed since then. But if you're a blind person, you are not allowed to sign a contract. Period. You can't see a contract period. How am I asked this Someone who was in the insurance industry why? And his response essentially was was it should be very obvious because you could be cheated. And I said, Oh, so you're telling me that no sighted people in Japan are ever cheated when it comes to signing contracts? Oh, exactly. Even though today, there is technology that allows me to fully read contracts. Right? All right, with that time, the Kurzweil Reading Machine, the mobile KNFB. Reader Mobile, although it hadn't come out in Japanese yet, but it has since. But the reality is, again, it's the prejudice. For many years, the Gallup polling organization and surveying people's fears, said that one of the top five fears that people had was going blind, not even disabilities, but losing eyesight, because that's for her that because that's what we emphasize eyesight. But it's not the way it ought to be. Over time, it will change. And I firmly believe that we will see a day when television commercials like the one I described earlier will be not tolerated. But I think we're not anywhere near there yet. Somebody once said to me, I look forward to the day when we don't have to even use the word accessible, because it's just such an automatic thing, that everything is included for everyone.   46:33 That's it.   Carla Birnberg ** 46:34 That's it. And I don't know if you know who Judy human is. I've been okay. But we both became really far. In her lifetime. And I don't know, I'm curious, your thoughts? Will we get there? I mean, I know we're trying to in Kenya, where companies hire these, again, like which they are persons with disabilities, they're trained, they're brilliant, they're ready to go, and they just start work and everything they need isn't an accommodation. It's just the way the office is. And I hope we get there here.   Michael Hingson ** 47:15 Yeah, I think we will. But I do think that the way the world is now we have to legislate it, because attitude only we're not there. You know, one of the big discussions in the world has been the internet. And many people have not made their websites accessible. Yeah, hence the need for companies like excessive be. Yeah, but but people have said, well, but we we don't need to do it because the internet came along, after the ADA. So the ADA covers physical things, but it doesn't cover the internet, because it's just the way it is. Well, yeah. The reality is is not what the ADEA says it doesn't talk about specifically and only physical places of business. And finally, in 2022, the Department of Justice, II dicted, if you will, that the internet is covered under Title, two of the Americans with Disabilities Act, and website should be made, accessible and inclusive. Yeah, but even so   Michael Hingson ** 48:30 a lot of well, most website owners don't pay attention to it, they think it's too expensive. But again, hence companies like accessibility and what access to be brings. But also, the the other aspect of it is that most people just don't even know they don't think about it. It doesn't need to be expensive to make the internet or your website accessible or inclusive. But it's also the right thing to do, because it covers more than just blindness. And the fact is that there's so many different kinds of disabilities that are affected by not having full access to the internet. And it's easy enough to do. And there are procedures and guidelines that describe exactly what needs to be done and how to do it. If people would just do it. That's it   Carla Birnberg ** 49:24 and people don't. Five years ago, I was people like and it's no better do better. I sent to a big social media person the other day. I love your I don't know, we're calling them exes, your tweets, but you never use alt text on your picture. And he said, I don't even know what that is. Yeah. And so I thought it's what you said that sometimes people are lazy websites and as people think it'd be too expensive. Sometimes they just don't think   Michael Hingson ** 49:54 some people just don't know. Yes, it we don't teach it In computer science schools very much like we should. I'm involved with an organization that is creating its website. And they went out and got bids from two local places to make the website up and running to get it up and running and operational. And I said, as as part of a discussion, and what are they doing regarding accessibility? Oh, they say that they know how to do that. And I said, Tell me more about that. Well, one of the companies said, Well, the fact is that it isn't the website design that has to be addressed. The person with a screen reader has to make the accommodations and make the modifications to work on the website.   50:47 Oh, that's not what we want to hear. Well, oh, that is so wrong. Oh, my God, and so neither ms on them.   Michael Hingson ** 50:55 Yeah. And so accessible is going to be the the product that they use, rightly so because the company, the website owner doesn't have a lot of money. But it will be possible to make the website accessible. And we found another company that will do the job for the same price or less than any of the other companies. And it will include accessibility. And they will actually use accessibility, because it's such a great product to use for making this kind of thing happen. But the reality is, the the original people who were looking at getting the website quotes, also were clueless. And they were ready to buy into well, it's got to be the sky with the screen reader just got to fix it. Until they learned, we don't teach it yet. We don't teach real inclusion yet, as a part of what we do, and it's something that we really need to look at. We'll get there. You're   Carla Birnberg ** 51:57 right, you're right. And it's people like me who I'm not doing any sort of web design. But I launched a substack. I was late to that party, and I wanted to make it accessible. So I always have a voiceover. And a bunch of readers have said to me, that super me that you read it. I'm like, well, it is super neat, but it's for accessibility. And like, oh, I don't even think about that. So I think it's the lay people, we need to start spreading the word. And I don't know how we do that, except for leading by example, practice living   Michael Hingson ** 52:27 by example, writing more articles, including disabilities in the conversation. And all too often we don't do that.   Carla Birnberg ** 52:35 And that's why one of the biggest reasons why I love where I work, I'm taking the backseat. And when it was the for profit, I had a whole team of persons with disabilities who told me what was what and how things should be and what language to use. And I listened. And now same thing, I will look to marry him or Daniel or Terry or Becky, what do we need here? Why do we need it all make it happen? But you tell me I don't have the lived experience?   53:04 Yeah. Well,   Michael Hingson ** 53:07 as I said, I think the most important thing we need to do is to really push the conversation to always involve disabilities. When you talk about diversity, you know, what is there? What is diversity to you?   Carla Birnberg ** 53:19 And, you know, I think I would have answered differently 10 years ago, but now it's always inclusion. It's well,   Michael Hingson ** 53:27 but that's, that's not diversity. Tell me what diversity is. And use your answer from 10 years ago. Okay.   Carla Birnberg ** 53:34 10 years ago, I would have thought it's bringing persons of color into the conversation and not having everybody looked the same   Michael Hingson ** 53:43 race, gender, sexual orientation,   Carla Birnberg ** 53:46 and maybe not even sexual orientation, because I think I would have been 10 years ago. Yeah, would have been,   Michael Hingson ** 53:52 but three and four years ago, yeah. But today, race, gender, sexual orientation. Diversity is about difference. And we don't include disabilities. We don't include persons with disabilities or or   Carla Birnberg ** 54:11 we do with the foundation. And when you what are your thoughts on that? Well, I think   Michael Hingson ** 54:16 the issue is that that's why I gave a speech entitled, moving from diversity to inclusion. You can't be inclusive, if you are not bringing disabilities into it, like as part of the population. But but we're, we're inclusive of color and so on, but you're not inclusive. You can't get away with it if we don't allow it. So we're not going to let inclusion be screwed up, if you will, like we have allowed diversity to be screwed up and not including disabilities. And that's what what we really need to do is to take that step of recognizing that we're all part of the same planet And we all need to recognize that and it's important to do that.   Carla Birnberg ** 55:06 And I know I mean, that's kind of where my project fits into the greater umbrella of the foundation is. The youth with disabilities, students with disabilities weren't graduating. And so the office landscapes weren't inclusive or reflecting the true population. And we need to help the students graduate so that the foundation can step in and train them and job place them so that we're inclusive. And the makeup of the officers look like the real makeup of society.   Michael Hingson ** 55:41 So what motivates you to get up in those, do those early morning or stay up for those late night phone calls?   Carla Birnberg ** 55:47 Oh, my gosh, thank goodness, I think this all the time, even if I didn't get up early. I'm not late night. So thank goodness, I don't work for a foundation in India. You know, I'm passionate, somewhat my Nespresso, which I love. But I've mentioned Mary Ann's name a million times, Beth, what do goo I love my team. And I think when the alarm goes off at four, it's noon, or it's one o'clock, what's going on? I just love it. It's, I don't know, it's my why it's that notion of, I'm not making huge difference in the world, somebody in the middle of Iowa has no idea who I am. But I'm making a tiny little impact, and I'm loving what I'm learning, and I'm loving every minute of it.   Michael Hingson ** 56:37 And that's the important thing. You love it. You know, you love it. And you're gonna continue to do it. If people want to reach out and learn more about the next step Foundation, or maybe become involved in some way, how can they do that?   Carla Birnberg ** 56:52 I would love it, I am up for a zoom anytime the best way to find me would be going to LinkedIn. And it's U P I L I Upili. message us, I would love to chat. We're always looking for insights for mental health professionals in the United States. Clearly, we're always looking for donors, but just conversations around what we're doing. And I'm always curious what other people are doing as well how they are making an impact.   Michael Hingson ** 57:23 So just search for U p i l i on LinkedIn. That's   Carla Birnberg ** 57:28 right Upili, we have a website, it's upili.org. But either of those two ways. You can find me. Okay,   Michael Hingson ** 57:35 and that's and that's all connected to the next step foundation.   Carla Birnberg ** 57:38 Yep, we're a project underneath them. Cool.   Michael Hingson ** 57:41 Well, I hope people will reach out. I know that they've heard me say some of these same things before a number of times. But it's great to hear the progress that you're making and the things that you're doing. And I really hope that we're able to contribute to bringing progress, both in East Africa and that we through this conversation, we'll get more people talking about it here in the US as well.   Carla Birnberg ** 58:10 Yes, and I always loved listening to you and talking to you. Because it gets me thinking in a different way to   Michael Hingson ** 58:15 well, we should do more of it than total, we can both learned to to get different perspectives. Well, I want to thank you for being here. And I want to thank all of you for and I want to thank you all for listening. We really appreciate it or watching if you're on YouTube. But wherever you're experiencing the podcast, we would really appreciate it if you'd give us a five star rating. We love those and we love your reviews. So please do that. If you'd like to reach out to me and have any questions or want to chat further about this, please feel free. You can reach me at Michaelhi at accessibe.com That's m i c h a e l h i at accessiBe  A C C E S S I B E.com. Or you can go to our podcast page, which is www dot Michael hingson.com/podcast. And Michael Hingson is spelled m i c h a e l h i n g s o n.com/podcasts. So we'd love to hear from you. And if any of you, including you, Carla, have a thought of anyone who else we ought to have on as a guest love to hear from you. We are always looking for people who want to come on and tell stories and talk about interesting things. And even if we talk about some of the same things we've talked about before on the podcast, I don't think it gets boring. And the more we do it, the more people will gain an understanding of it. So we sure look forward to hearing from you with ideas of guests and other people who want to be part of the podcast. So thank you very much and really appreciate your your involvement in that. But again, Carla, I want to thank you for being here and for taking the time to be with us today. Thank you so much for having me. It was so fun   Michael Hingson ** 1:00:07 You have been listening to the Unstoppable Mindset podcast. Thanks for dropping by. I hope that you'll join us again next week, and in future weeks for upcoming episodes. To subscribe to our podcast and to learn about upcoming episodes, please visit www dot Michael hingson.com slash podcast. Michael Hingson is spelled m i c h a e l h i n g s o n. While you're on the site., please use the form there to recommend people who we ought to interview in upcoming editions of the show. And also, we ask you and urge you to invite your friends to join us in the future. If you know of any one or any organization needing a speaker for an event, please email me at speaker at Michael hingson.com. I appreciate it very much. To learn more about the concept of blinded by fear, please visit www dot Michael hingson.com forward slash blinded by fear and while you're there, feel free to pick up a copy of my free eBook entitled blinded by fear. The unstoppable mindset podcast is provided by access cast an initiative of accessiBe and is sponsored by accessiBe. Please visit www.accessibe.com . AccessiBe is spelled a c c e s s i b e. There you can learn all about how you can make your website inclusive for all persons with disabilities and how you can help make the internet fully inclusive by 2025. Thanks again for Listening. Please come back and visit us again next week.

In this part 1 of our 2-part podcast series on Asthma Management we explore a systematic approach to managing patients presenting to the ED with asthma exacerbations. Our discussion will emphasize the critical role of a thorough history and physical examination in effectively stratifying patient risk and guiding treatment/disposition decisions. Additionally, we'll examine the importance of providing comprehensive discharge medications and instructions to mitigate both mortality and morbidity associated with asthma exacerbations. We answer questions such as: which patients, if any, require peak expiratory flow measurements in the ED? Why is it so important to add steroid MDI therapy to oral steroid therapy in patients being discharged from the ED after an asthma exacerbation? What are the most predictive variables to risk stratify patients with asthma exacerbations to help guide treatment and disposition? and many more. Stay tuned for Part 2, where we'll delve deep into the management of the crashing asthmatic. Please support EM Cases FOAMed with a donation: https://emergencymedicinecases.com/donation/ The post Ep 192 ED Adult Asthma Management Strategies For Improved Prognosis – A Stepwise Approach appeared first on Emergency Medicine Cases.

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Listen to the Q&A between Tino Münster and Marcelo Gama de Abreu as they discuss the article “Variable ventilation versus stepwise lung recruitment manoeuvres for lung recruitment: A comparative study in an experimental model of atelectasis”, found in the July 2023 issue of the EJA.

In this episode, Lori Sims, founder of Nacho Kids Nacho Parenting, talks with Alison O'Mahony of Be Step Wise about expectations. We have expectations every day from almost everyone we encounter. Why do we have these expectations? What expectations should we have in the blend? Are these expectations realistic?   In this episode, we discuss the following: Feeling different towards kids Can't love people on demand Expectations = Disappointment   Nacho Kids Academy Nacho Parenting Success Story: “My life will forever be better because of Lori and David's Nacho Academy!” ~ T.P.  

In this episode, Lori, founder of Nacho Kids Nacho Parenting, interviews stepmom Alison with Be Stepwise. Alison, who was a stepkid herself, has been blending for 28 years, has two stepkids and two bio kids. Her stepkids' mom was deceased and their grandmother took on a mothering role. Alison's mother also passed away, so Alison felt she could relate to her stepkids' loss of their mother. In this episode, we discuss the following: When the grandmother takes over the mothering role Stepparents finding fault with stepkids Kids still grieving when parent re-partners Stepparents should not assume their role as a parent Personal growth as a stepmom Nacho Kids Academy Nacho Parenting Success Story: “Because of Nacho Parenting, I was able to come off my depression medicine! I never thought I'd be able to do that! Even my doctor is impressed with the results of Nacho Parenting. After seeing the change it made in me, she said she's going to refer patients to the Nacho Academy!” H.H.  

AF screening, BNP, a new SGLT2 inhibitor, a sky-is-blue study, and the UK Mini Mitral surgical trial are discussed in this week's podcast This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I AF Screening - Effects of Atrial Fibrillation Screening According to N-Terminal Pro-B-Type Natriuretic Peptide: A Secondary Analysis of the Randomized LOOP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064361 - Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01698-6 - Natural History of Subclinical Atrial Fibrillation Detected by Implanted Loop Recorders https://www.jacc.org/doi/full/10.1016/j.jacc.2019.09.050 - Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care https://jamanetwork.com/journals/jamacardiology/fullarticle/2801362 - Stepwise mass screening for atrial fibrillation using N-terminal pro b-type natriuretic peptide: the STROKESTOP II study design https://doi.org/10.1093/europace/euw319 - Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068511/ II Frailty and GDMT of HFrEF Frailty Linked to Lower Use of Guideline Treatments in HFrEF https://www.medscape.com/viewarticle/993218 - Physical Frailty and Use of Guideline‐Recommended Drugs in Patients With Heart Failure and Reduced Ejection Fraction https://www.ahajournals.org/doi/10.1161/JAHA.122.026844 III Sotagliflozin FDA Approves New Drug, Sotagliflozin, for Heart Failure https://www.medscape.com/viewarticle/992518 - Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2030186 - Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2030183 IV Mini-Mitral Support for Minimally Invasive Mitral Valve Repair: Mini Mitral Published https://www.medscape.com/viewarticle/993191 - Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair https://jamanetwork.com/journals/jama/article-abstract/2805908 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact: news@medscape.net

In this session we will examine the fundamentals of the pre-hospital airway from airway assessment all the way through to the difficulties posed in practice. We will also look at the management from a stepwise concept all the way through to the use of invasive surgical techniques to manage the airway. We will also examine some of the optimal methods used to monitor the respiratory effort and when and when not to intervene. We will also examine the current utility and debate around Direct Laryngoscopy (DL) and Video Laryngoscopy (VL) and whether VL is around to stay within practice. To do this I have with me John Chatterjee. John is a consultant anaesthetist with an interest in pre-hospital care and difficult airway, thoracic and high-risk anaesthesia. He has worked with and educated clinicians around the world in various ambulance and hospital services including places like New Zealand, Sydney, Liberia, Ethiopia, Ukraine and in the UK where he has worked with HEMS and BASICS. John is as an anaesthetist at Guys and St Thomas', and a Consultant with London's Air Ambulance at the Royal London. In the episode we examine: The challenges of the pre-hospital airway How to assesses the difficulty of an airway from sight and brief assessment Declaration of the findings and plan VL vs DL and where VL is going from a SOP and utilisation tool. Stepwise management and understanding where to come in on the management plan. Assessment of respiratory effort Thoughts on RSI compared to retrospective practice. Tips on surgical airways Seminal airway research in the last 10 years – Impact Brain Apnoea Seminal cases that John has learnt a lot from Final thoughts from John and take-home messages. John mentions these two papers within the conversation: Difficult Airway Society (DAS) 2015 guidelines for management of unanticipated difficult intubation in adults: https://aimeairway.ca/userfiles/26556848_Difficult_Airway_Society_2015_guidelines_for_management_of_unanticipated_difficult_intubation_in_adults.pdf Observational study of the success rates of intubation and failed intubation airway rescue techniques in 7256 attempted intubations of trauma patients by pre-hospital physicians https://academic.oup.com/bja/article/113/2/220/1745948 My thanks to John for an insightful and engaging conversation.

Perhaps, like most people, you know what you should be eating, but somehow it doesn't always go to plan. Our relationship with food and our appetite cues can trigger us to either overeat or eat the wrong things and it's a topic that probably hasn't had the coverage it should and that certainly fascinates us at SHL. We asked Dr Helen McCarthy, clinical psychologist to come on the pod and talk to us about how she helps people to retrain their appetite. Dr Helen shares how she helps people get back into touch with their hunger signals which leads to a sense of freedom and increased pleasure from food. We talk about: Fasting and how it relates to appetite How to learn to listen to your natural hunger cues Deconstructing emotional eating How her approach leads to increased pleasure from food Why focussing on future goals and values is the key Stepwise behavioural change and how to manage obstacles This episode is full of simple practical tips to help you understand your own appetites, cravings and emotional eating To find out more about Dr Helen and her work, which includes some brilliant webinars  Follow her on Instagram Go to her website Connect with her on Linked In Or buy her book How to Retrain Your Appetite                

Work/Life Balance - Seavron Banus works in private equity at Berkshire Partners, is the founder of Stepwise (a financial education platform), and also works as a personal finance/leadership coach. We discuss finding work/life balance amidst competing priorities, bringing multiple skills to bear on one problem, and building a meaningful business that actually helps people. You can check out Stepwise here: https://stepwisewealth.com/ Get ChroniFI: https://www.chronifi.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.03.521946v1?rss=1 Authors: Paul, M. A., Sigoillot, S. M., Marti, L., Delagrange, M., Mailly, P., Selimi, F. Abstract: Brain function relies on the generation of a large variety of morphologically and functionally diverse, but specific, neuronal synapses. Here, we show that, initially, synapse formation on a common target neuron, the cerebellar Purkinje cells, involves a presynaptic secreted protein common for all types of excitatory inputs. The molecular program then evolves only in one of the inputs with the additional expression of a combination of presynaptic secreted proteins that specify the mature pattern of connectivity on the target. These results show that some inputs actively and gradually specify their synaptic molecular identity while others rely on the "original code". Thus, the molecular specification of excitatory synapses, crucial for proper circuit function, is acquired in a stepwise manner during mouse postnatal development and obeys input-specific rules. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.08.515694v1?rss=1 Authors: Cho, C.-Y., O'Farrell, P. H. Abstract: Eukaryotic transcription begins with the binding of transcription factors (TFs), which promotes the subsequent recruitment of coactivators and pre-initiation complexes. It is commonly assumed that these factors eventually co-reside in a higher-order structure, allowing distantly bound TFs to activate transcription at core promoters. Here we performed live imaging of endogenously tagged proteins, including the pioneer TF Zelda, the coactivator dBrd4, and RNA polymerase II (RNAPII), in early Drosophila embryos. We show that these factors are sequentially and transiently recruited to discrete clusters during activation of non-histone genes. We present evidence that Zelda acts with the acetyltransferase dCBP to nucleate dBrd4 hubs, which then trigger pre-transcriptional clustering of RNAPII; continuous transcriptional elongation then disperses clusters of dBrd4 and RNAPII. Our results suggest that activation of transcription by eukaryotic TFs involves a succession of distinct biochemical complexes that culminate in a self-limiting burst of transcription. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Marked pregnancy-induced insulin resistance may require that patient receive high-dose large-volume insulin injections. However, these types of injections may reduce the therapeutic effectiveness of the insulin.In this episode of the Better Edge podcast, Grazia Aleppo, MD, and Emily D. Szmuilowicz, MD, discuss their recent research published in Postgraduate Medicine. Their research proposes a new treatment regimen for pregnancy-induced insulin resistance that is guided by continuous glucose monitoring (CGM). This aims to give internists and family medicine physicians a simplified and consistent approach to CGM interpretation that can be easily implemented in a brief office visit.

As a business strategist, executive coach, and builder by nature, Seavron has spent the past 15+ years blending behavioral psychology, organizational design, and process improvement at companies across North & South America. As part of his passion for growth and improvement, Seavron started the educational platform Stepwise, which aims to make financial knowledge more accessible. Stepwise offers actionable, step-by-step advice on how to save, invest and build wealth. The advice is based on his own experience of going from $30K in student loan debt at the age of 22 to $100K saved and invested by 27. In this episode, we discuss developing a mindset that leads to saving, investing, and building wealth, the psychology of money, how to understand our financial motivators and how our values and personal goals influence them, and strategies and processes for our financial life. Free Resources: How To Set Financial Goals: 3 Simple Steps 6-Step Guide: How To Save, Invest, And Build Wealth For more go to: www.scottmlynch.com Join my free Discord group: Motivated Minds Want to receive weekly emails where I breakdown step-by-step processes to master your mindset and practical growth tips? Sign up for my free weekly newsletter. Our mind is our most powerful tool. It's time to start investing in it. Join 143 other students pre-enrolled in my academy. Follow me on social for more inspiration: Instagram Facebook TikTok Twitter Start setting goals and achieving them: Schedule a one-on-one session. Want to be featured in a future episode? Leave a review here (even one sentence helps)! Sponsors mentioned in this episode: HashDash Music by: Blaize Trulson Produced by Legacy Divisions.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.25.505256v1?rss=1 Authors: Matsunaga, M., Yamamoto, R., Kita, T., Ohnishi, H., Yamamoto, N., Okano, T., Omori, K., Nakagawa, T. Abstract: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair cells, we used single-cell RNA sequencing during hair cell regeneration in explant cultures of chick basilar papillae. We identified dynamic changes in the gene expression of supporting cells, and the pseudotime trajectory analysis demonstrated the stepwise fate conversion from supporting cells to hair cells. Initially, supporting cell identity was erased and transition to the precursor state occurred. A subsequent gain in hair cell identity progressed together with downregulation of precursor-state genes. Transforming growth factor beta receptor 1-mediated signaling was involved in induction of the initial step, and its inhibition resulted in suppression of hair cell regeneration. Our data provide new insights for understanding fate conversion from supporting cells to hair cells in avian basilar papillae. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

https://podcast.evangelicalendtimemachine.com/wp-content/uploads/2022/06/Stepwise-takeover-of-mankind.mp3

This question refers to Sections 3.2 and 3.3 of the 2021 ESC CV Prevention Guidelines. The question is asked by CardioNerds Academy Intern, student Dr. Hirsh Elhence, answered first by Ohio State University Cardiology Fellow Dr. Alli Bigeh, and then by expert faculty Dr. Eugene Yang.Dr. Yang is professor of medicine of the University of Washington where he is medical director of the Eastside Specialty Center and the co-Director of the Cardiovascular Wellness and Prevention Program. Dr. Yang is former Governor of the ACC Washington Chapter and current chair of the ACC Prevention of CVD Section.The CardioNerds Decipher The Guidelines Series for the 2021 ESC CV Prevention Guidelinesrepresents a collaboration with the ACC Prevention of CVD Section, the National Lipid Association, and Preventive Cardiovascular Nurses Association. Question #1 A 48-year-old Pakistani woman with rheumatoid arthritis comes to your clinic asking how she can reduce her risk of ASCVD. Her mother died of an MI at age 45, her father is healthy at age 79. Her calculated 10-year risk based on SCORE2 is 3%. SBP is 120 mmHg, LDL is 120 mg/dL. What is the next best step? A. Order an echocardiogram B. Schedule a follow-up appointment in 1 year C. Discuss initiating a statin D. Repeat lipid panel in 3-5 years  Answer #1 Answer: C. Discuss Initiating a statin The absolute benefit derived from risk factor modification depends on the absolute risk of CVD and the absolute improvements in each risk factor category. Risk factor treatment recommendations are based on categories of CVD risk (“low-to-moderate”, “high”, and “very high”). The cut-off risk levels for these categories are numerically different for various age groups to avoid undertreatment in the young and to avoid overtreatment in the elderly. As age is a major driver of CVD risk, but lifelong risk factor treatment benefit is higher in younger people, the risk thresholds for considering treatment are lower for younger people as per the ESC guidelines. Treatment decisions should be made with shared decision-making valuing patient preference.  Option A is INCORRECT- there is a lack of convincing evidence that echocardiography improves CVD risk reclassification, and it is NOT recommended to improve CV risk prediction. (Class III, LOE B) Option B is INCORRECT- simply doing nothing is not appropriate for this patient with elevated CVD risk.  Option C is CORRECT- This patient has a seemingly low 10-year CVD risk based on SCORE 2 of 3% and her SBP is controlled; however, given her age she is considered as having high CVD risk, therefore treatment should be considered. Stepwise approach involves targeting LDL

There was one place where there were hundreds, perhaps thousands of magical ley lines that gathered and writhed like snakes. It was destiny that this should be the greatest city ever built: Frostford. Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 2 of 2. Learn more about your ad choices. Visit megaphone.fm/adchoices

There was one place where there were hundreds, perhaps thousands of magical ley lines that gathered and writhed like snakes. It was destiny that this should be the greatest city ever built: Frostford. Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 2 of 2. Learn more about your ad choices. Visit megaphone.fm/adchoices

Every world in this realm is crisscrossed by ley lines; filaments of earth energy that connect places of worship, monuments, and historical sites. You have passed through innumerable ley lines in your life: think of any desolate place you have been where the hair on the back of your neck stood up for no reason you could fathom... Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 1 of 2. Learn more about your ad choices. Visit megaphone.fm/adchoices

Every world in this realm is crisscrossed by ley lines; filaments of earth energy that connect places of worship, monuments, and historical sites. You have passed through innumerable ley lines in your life: think of any desolate place you have been where the hair on the back of your neck stood up for no reason you could fathom... Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 1 of 2. Learn more about your ad choices. Visit megaphone.fm/adchoices

Amanda Estapa, ACNP-BC, CWS, FACCWS
, Robert J. Klein, DPM, FACFAS, CWS
 and Todd Shaffett, DNP, FNP, CWS, FACCWS, DAPWCA 
will discuss determining when to initiate negative pressure wound therapy (NPWT) for chronic wound management and examine the science and clinical application, explain the clinical application and best practice use of advanced wound dressings, and explore illustrative cases outlining a stepwise approach to transitioning from NPWT to advanced wound dressings. To view program information/faculty disclosures and claim your CE credit after the session, visit centerforhealingsolutions.com/podcasts.

Meet Caroline Wanjiku, cofounder of Daproim Africa, and Victor Basta, CEO of DAI Magister, and learn how one intrepid Kenyan entrepreneur overcame adversity to transform her bootstrapped social enterprise into a strategic acquisition.Caroline's entrepreneurial journey began like most other ambitious founders. She and her business partner (and eventual husband) created Daproim in 2006 with a vision to make Kenya a destination for IT outsourcing. A chance encounter with the Rockefeller Foundation in 2011 led to a grant and a realization that the business they were building was also a social enterprise. Caroline explains:“We were employing friends, women, mainly people who were from underprivileged backgrounds. So, when we bumped into Rockefeller Foundation they were quick to tell us that what you are doing is actually called social impact. You know, we didn't have a word for it until then.”A few years and 500 employees later, a tragic turn of events changed everything. On the day she was giving birth to her first child, her husband and co-founder also entered the hospital with a life-threatening disease. Caroline had no choice but to take on the role of CEO.“My first reaction was like, I can't do this. And one of my mentors came and visited me and told me, "You know what? You need to do it for your child. Find a way to gather yourself, take as much time as you need, but the goal is to make sure that this business continues."Victor Basta also believes in the power of mentorship, especially in an ecosystem like Africa where “hardly anybody's done an exit...the playbook hasn't been written.” Victor helps fast-growing, tech-enabled businesses like Daiprom do everything from raising capital to acquisitions. And when Caroline was approached by StepWise, an American outsourcing company, she sought out mentors again to help her understand the deal on the table and keep her emotions in check.Victor advises “don't talk to very many people about it because you are going to be in sell mode because of the lack of experience. It would be useful to be able to find somebody in your broader orbit that has actually gone through it. You know, they may help you at least avoid going what I would call guardrail to guardrail with your emotions.”In February 2020, the day before the lockdown, StepWise acquired Daproim. But it wasn't all smooth sailing and Caroline admits to mistakes and misunderstandings, namely assuming that she would remain as CEO after the acquisition.“So in my mind, I thought automatically I'd remain as CEO. So, I didn't have any doubts. I didn't think I needed to bring it up until later. I'd advise anyone to just make sure you talk about everything and not to assume.”When Caroline eventually decided to move on from Daproim, it was not without the advice of her trusted mentors. Listen to Caroline's amazing story and Victor's insights to learn how to prepare for the unexpected and avoid potential pitfalls—before, during and after an acquisition.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Building a profitable digital product suite shouldn't be complicated.In fact, knowing exactly what your product suite entails makes your customer journey easier to createIn this episode, I'll introduce you to my STEPwise approach to building a strategic digital product suite so you can attract and convert your dream clients BY THE TIME YOU FINISH LISTENING, YOU'LL DISCOVER: Why cookie cutter strategies won't work for your digital product businessThe mistakes entrepreneurs make that repels their buyersThe four types of digital products that make up a strategic product suiteIf this episode inspires you, I'd love to hear your biggest takeaway. Take a screenshot of you listening on your device, post it to your Instagram stories and tag me, @desoladavis.  Then, make sure you're following me on Instagram, where you can see behind the scenes footage of how I craft the customer journey and how you can too.

Co to znaczy dojrzałość lidera? Jak dojrzewa się do bycia liderem, a nie tylko "szefem"? Czy ową dojrzałość pewnego dnia po prostu się osiąga, czy może ciągle należy do niej dążyć? Jak taką dojrzałość wzmacniać? Czy przewodzenie ludziom to „władza”, czy raczej „odpowiedzialność”? O doświadczeniach zdobywanych w branży IT i byciu dojrzałym liderem rozmawiamy z Krzysztofem Szukieciem, liderem, przedsiębiorcą z wieloletnim doświadczeniem w branży IT, założycielem software house Stepwise. Rozmowę prowadzi dr Magdalena Łużniak-Piecha, wykładowczyni na kierunku Zarządzanie na Uniwersytecie SWPS. 01:47 - Kim jest “dojrzały lider”?10:45 - Jak dojrzewa się do bycia liderem?22:15 - Kiedy lider jest gotowy na podjęcie decyzji o założeniu własnej firmy (na rynku IT)?  27:49 - W jaki sposób branża IT przyczynia się do transformacji cyfrowej innych branż?34:50 - Czy stawianie wyzwań w swojej branży i ambitne podejście do kształtowania rynku jest dziś elementem polityki motywacyjnej firm?  37:12 - Jak w byciu liderem wygląda balans władzy i odpowiedzialności?40:00 - Jak nie dać się przytłoczyć odpowiedzialnością i zachować zdrowy rozsądek? Strefa Zarządzania Uniwersytetu SWPS to projekt popularyzujący wiedzę z zakresu zarządzania. W jego ramach eksperci przybliżają takie zagadnienia, jak: zarządzanie i przywództwo w czasach zmian, tworzenie innowacji w biznesie, budowa gospodarki relacyjnej zamiast transakcyjnej, tworzenie efektywnej komunikacji wewnętrznej. Założeniem projektu jest udostępnienie rzetelnej wiedzy wszystkim zainteresowanym tą tematyką – niezależnie od czasu i miejsca, w jakim się znajdują. Więcej informacji o projekcie: www.zarzadzanie.swps.pl   Interesujesz się zarządzaniem? Dołącz do innych w grupie Strefy Zarządzania Uniwersytetu SWPS na Facebooku (https://www.facebook.com/groups/StrefaZarzadzania). 

    Stepwise Melody Rule   Learn how to avoid this common fault many songwriters and producers make in their melodies. But first... Tea! Hello revolutionary music makers, we are Kate and Ray Harmony (AKA Revolution Harmony), and welcome to Hack Music Theory, the fast, easy and fun way to make music! If you’re new to theory, or if you just want a refresher, then read our free book "12 Music Theory Hacks to Learn Scales & Chords". It’ll give you a super solid music theory foundation in just 30 minutes. The free download is below. Enjoy!   The Fault Right, first things first. We intentionally use the word “fault” in this context, because music is an art, so technically there can’t be any mistakes. But, and it’s a big but, there can definitely be faults, as faults are weaknesses. And unfortunately, when songwriters and producers compose by ear, their music ends up with many faults! For the record, though, it’s not their fault. It’s the fault of our current music education system that focuses on classical and jazz, which are irrelevant for most songwriters and producers. This means they struggle finding resources to learn relevant music theory, which often results in them composing music by ear instead. This is a huge problem in the music world, and it was the inspiration for us launching Hack Music Theory back in 2016, so songwriters and producers could finally have a place to learn theory that’s actually relevant to the music they make! Now, let’s get back to that melody. So, what is the theory fault here? Well, it contains more than three stepwise notes from the scale. In the beginning of the melody, it goes: E, D, C, B. And in the middle of the melody, it goes: E, D, C, B, A. We refer to this as the “practising scales” fault, because whenever a melody goes stepwise through the scale (up or down), it literally sounds like the producer accidentally hit the Record button while they were practising their scales. This fault is extremely common, as songwriters and producers who compose by ear don’t have the confidence that theory gives you to experiment, so they tend to play it safe and stick with a lot of stepwise movements. You see, our ears will always be led by musical gravity to the predictable note, like resolving the 7 up to the 8. Boring! If we wanna make cool music that stands out, we need to use theory! And by the way, if you were wondering, our example is in the key of A minor, which is all the white notes from A to A, and the tempo is 100 BPM.   The Fix You know what’s interesting? Now that you’re aware of this fault, you’ll start noticing it everywhere. It really is sad how common it is! But, there’s a super easy hack to fix this fault. All you have to do is change a note (or two) in each scale segment, to break up that stepwise movement. In our example, we only had to change one note in each segment to fix this fault. After this tweak, our melody now has no more than three stepwise notes, which is the maximum you want. It’s truly amazing how changing just one note can have such a massive impact on a melody!   The Rule So to conclude, our Stepwise Melody Rule is to have no more than three stepwise notes in your melodies (unless for some good reason, you really really want that). Lastly, if you need more help writing melodies, then simply use our "Melody Checklist", which tells you exactly what to do and what not to do in your melodies. The "Melody Checklist" can be found in our Songwriting & Producing PDF. Thanks for being here in the Hack Music Theory community, we really appreciate you, and we'll see you next time. Until then, we're sending you good vibes and gratitude :)     Free Download     Wooohooo!!! You’re a mere 30 minutes away from being even smarter than you already are. Just head on over to your inbox now for your free download. There was an error submitting your subscription. Please try again.   “The most brilliant, fast, easy & fun music theory book I’ve ever seen!” DEREK SIVERS, CD Baby founder We use this field to detect spam bots. If you fill this in, you will be marked as a spammer. DOWNLOAD FREE BOOK /* Layout */ .ck_form { /* divider image */ background: #EAE9EA url(data:image/gif;base64,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) repeat-y center top; font-family: 'Montserrat'; line-height: 1.5em; overflow: hidden; color: #000000; font-size: 16px; border-top: none; border-top-color: #666666; border-bottom: none; border-bottom-color: #3d3d3d; -webkit-box-shadow: none; -moz-box-shadow: none; box-shadow: none; clear: both; margin: 0px 0px; } .ck_form, .ck_form * { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; } #ck_subscribe_form { clear: both; } /* Element Queries — uses JS */ .ck_form_content, .ck_form_fields { width: 50%; float: left; padding: 5%; } .ck_form.ck_horizontal { } .ck_form_content { border-bottom: none; } .ck_form.ck_vertical { background: #fff; } .ck_vertical .ck_form_content, .ck_vertical .ck_form_fields { padding: 10%; width: 100%; float: none; } .ck_vertical .ck_form_content { border-bottom: 1px dotted #aaa; overflow: hidden; } /* Trigger the vertical layout with media queries as well */ @media all and (max-width: 499px) { .ck_form { background: #fff; } .ck_form_content, .ck_form_fields { padding: 10%; width: 100%; float: none; } .ck_form_content { border-bottom: 1px dotted #aaa; } } /* Content */ .ck_form_content h3 { margin: 0px 0px 0px; font-size: 0px; padding: 0px; } .ck_form_content p { font-size: 14px; } .ck_image { float: left; margin-right: 5px; } /* Form fields */ .ck_errorArea { display: none; } #ck_success_msg { padding: 10px 10px 0px; border: solid 1px #ddd; background: #eee; } .ck_label { font-size: 14px; font-weight: bold; } .ck_form input[type="text"] { font-size: 16px; text-align: center; margin-top: 20px; margin-bottom: 0px; padding: 8px 8px; width: 100%; border: 1px solid #d6d6d6; /* stroke */ -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ background-color: #fff; /* layer fill content */ height: auto; } .ck_form input[type="email"] { font-size: 16px; text-align: center; margin-top: 0px; margin-bottom: 15px; padding: 8px 8px; width: 100%; border: 1px solid #d6d6d6; /* stroke */ -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ background-color: #fff; /* layer fill content */ height: auto; } .ck_form input[type="text"]:focus, .ck_form input[type="email"]:focus { outline: none; border-color: #aaa; } .ck_checkbox { padding: 10px 0px 10px 20px; display: block; clear: both; } .ck_checkbox input.optIn { margin-left: -20px; margin-top: 0; } .ck_form .ck_opt_in_prompt { margin-left: 4px; } .ck_form .ck_opt_in_prompt p { display: inline; } .ck_form .ck_subscribe_button { width: 100%; color: #fff; margin: 0px 0px 0px; padding: 8px 8px; font-size: 18px; background: #c83232; -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ cursor: pointer; border: none; text-shadow: none; } .ck_form .ck_guarantee { color: #626262; font-size: 12px; text-align: center; padding: 5px 0px; display: block; } .ck_form .ck_powered_by { display: block; color: #aaa; } .ck_form .ck_powered_by:hover { display: block; color: #444; } .ck_converted_content { display: none; padding: 5%; background: #fff; } /* v6 */ .ck_form_v6 #ck_success_msg { padding: 0px 10px; } @media all and (max-width: 403px) { .ck_form_v6.ck_modal .ck_close_link { top: 30px; } } @media all and (min-width: 404px) and (max-width: 499px) { .ck_form_v6.ck_modal .ck_close_link { top: 57px; } }      Want More? 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Email Address SUBSCRIBE /* Layout */ .ck_form.ck_naked { /* divider image */ background: transparent; line-height: 1.5em; overflow: hidden; color: #666; font-size: 16px; border: none; -webkit-box-shadow: none; -moz-box-shadow: none; box-shadow: none; clear: both; margin: 0px 0px; text-align: center; } .ck_form.ck_naked p { padding: 0px; } .ck_form, .ck_form * { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; } .ck_form.ck_naked .ck_form_fields { width: 100%; float: left; padding: 3%; } /* Form fields */ .ck_errorArea { display: none; /* temporary */ } #ck_success_msg { padding: 10px 10px 0px; border: solid 1px #ddd; background: #eee; } .ck_form.ck_naked input[type="text"], .ck_form.ck_naked input[type="email"] { font-size: 16px; font-family: Montserrat; text-align: center; padding: 10px 8px; width: 34%; border: 1px solid #d6d6d6; /* stroke */ -moz-border-radius: 0px; -webkit-border-radius: 0px; border-radius: 30px; /* border radius */ background-color: #fff; /* layer fill content */ margin-bottom: 5px; height: auto; float: left; margin: 0px; margin-right: 1%; height: 42px; } .ck_form input[type="text"]:focus, .ck_form input[type="email"]:focus { outline: none; border-color: #aaa; } .ck_form.ck_naked .ck_subscribe_button { width: 100%; color: #fff; margin: 0px; padding: 9px 0px; font-size: 16px; background: #c83232; -moz-border-radius: 0px; -webkit-border-radius: 0px; border-radius: 30px; /* border radius */ cursor: pointer; border: none; text-shadow: none; width: 30%; float: left; height: 42px; } .ck_converted_content { display: none; padding: 5%; background: #fff; } /* max width 500 */ .ck_form.ck_naked.width500 .ck_subscribe_button { width: 100%; float: none; margin-top: 5px; } .ck_form.ck_naked.width500 input[type="text"], .ck_form.ck_naked.width500 input[type="email"] { width: 49%; } .ck_form.ck_naked.width500 input[type="email"] { margin-right: 0px; width: 50%; } /* max width 400 */ .ck_form.ck_naked.width400 .ck_subscribe_button, .ck_form.ck_naked.width400 input[type="text"], .ck_form.ck_naked.width400 input[type="email"] { width: 100%; float: none; margin-top: 5px; } .ck_slide_up, .ck_modal, .ck_slide_up .ck_naked, .ck_modal .ck_naked { min-width: 400px; } .page .ck_form.ck_naked { margin: 50px auto; max-width: 700px; } /* v6 */ .ck_slide_up.ck_form_v6, .ck_modal.ck_form_v6, .ck_slide_up.ck_form_v6 .ck_naked, .ck_modal.ck_form_v6 .ck_naked { min-width: 0 !important; } .ck_form_v6 #ck_success_msg { padding: 0px 10px; } @media all and (max-width: 403px) { .ck_form_v6.ck_modal .ck_naked { padding-top: 0px; } } @media all and (max-width: 499px) { .ck_form_v6.ck_modal .ck_naked + .ck_close_link { color: #fff; top: 10px; } } .ck_form_v6.ck_slide_up .ck_naked + .ck_close_link { right: 10px; top: -5px; } @media all and (min-width: 600px) { .ck_form_v6.ck_slide_up .ck_naked + .ck_close_link { right: 35px; } }      Podcast Listen below, or on any podcast app.

    Stepwise Melody Rule   Learn how to avoid this common fault many songwriters and producers make in their melodies. But first... Tea! Hello revolutionary music makers, we are Kate and Ray Harmony (AKA Revolution Harmony), and welcome to Hack Music Theory, the fast, easy and fun way to make music! If you're new to theory, or if you just want a refresher, then read our free book "12 Music Theory Hacks to Learn Scales & Chords". It'll give you a super solid music theory foundation in just 30 minutes. The free download is below. Enjoy!   The Fault Right, first things first. We intentionally use the word “fault” in this context, because music is an art, so technically there can't be any mistakes. But, and it's a big but, there can definitely be faults, as faults are weaknesses. And unfortunately, when songwriters and producers compose by ear, their music ends up with many faults! For the record, though, it's not their fault. It's the fault of our current music education system that focuses on classical and jazz, which are irrelevant for most songwriters and producers. This means they struggle finding resources to learn relevant music theory, which often results in them composing music by ear instead. This is a huge problem in the music world, and it was the inspiration for us launching Hack Music Theory back in 2016, so songwriters and producers could finally have a place to learn theory that's actually relevant to the music they make! Now, let's get back to that melody. So, what is the theory fault here? Well, it contains more than three stepwise notes from the scale. In the beginning of the melody, it goes: E, D, C, B. And in the middle of the melody, it goes: E, D, C, B, A. We refer to this as the “practising scales” fault, because whenever a melody goes stepwise through the scale (up or down), it literally sounds like the producer accidentally hit the Record button while they were practising their scales. This fault is extremely common, as songwriters and producers who compose by ear don't have the confidence that theory gives you to experiment, so they tend to play it safe and stick with a lot of stepwise movements. You see, our ears will always be led by musical gravity to the predictable note, like resolving the 7 up to the 8. Boring! If we wanna make cool music that stands out, we need to use theory! And by the way, if you were wondering, our example is in the key of A minor, which is all the white notes from A to A, and the tempo is 100 BPM.   The Fix You know what's interesting? Now that you're aware of this fault, you'll start noticing it everywhere. It really is sad how common it is! But, there's a super easy hack to fix this fault. All you have to do is change a note (or two) in each scale segment, to break up that stepwise movement. In our example, we only had to change one note in each segment to fix this fault. After this tweak, our melody now has no more than three stepwise notes, which is the maximum you want. It's truly amazing how changing just one note can have such a massive impact on a melody!   The Rule So to conclude, our Stepwise Melody Rule is to have no more than three stepwise notes in your melodies (unless for some good reason, you really really want that). Lastly, if you need more help writing melodies, then simply use our "Melody Checklist", which tells you exactly what to do and what not to do in your melodies. The "Melody Checklist" can be found in our Songwriting & Producing PDF. Thanks for being here in the Hack Music Theory community, we really appreciate you, and we'll see you next time. Until then, we're sending you good vibes and gratitude :)     Free Download     Wooohooo!!! You're a mere 30 minutes away from being even smarter than you already are. Just head on over to your inbox now for your free download. There was an error submitting your subscription. Please try again.   “The most brilliant, fast, easy & fun music theory book I've ever seen!” DEREK SIVERS, CD Baby founder We use this field to detect spam bots. If you fill this in, you will be marked as a spammer. DOWNLOAD FREE BOOK /* Layout */ .ck_form { /* divider image */ background: #EAE9EA url(data:image/gif;base64,R0lGODlhAQADAIABAMzMzP///yH/C1hNUCBEYXRhWE1QPD94cGFja2V0IGJlZ2luPSLvu78iIGlkPSJXNU0wTXBDZWhpSHpyZVN6TlRjemtjOWQiPz4gPHg6eG1wbWV0YSB4bWxuczp4PSJhZG9iZTpuczptZXRhLyIgeDp4bXB0az0iQWRvYmUgWE1QIENvcmUgNS41LWMwMTQgNzkuMTUxNDgxLCAyMDEzLzAzLzEzLTEyOjA5OjE1ICAgICAgICAiPiA8cmRmOlJERiB4bWxuczpyZGY9Imh0dHA6Ly93d3cudzMub3JnLzE5OTkvMDIvMjItcmRmLXN5bnRheC1ucyMiPiA8cmRmOkRlc2NyaXB0aW9uIHJkZjphYm91dD0iIiB4bWxuczp4bXA9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC8iIHhtbG5zOnhtcE1NPSJodHRwOi8vbnMuYWRvYmUuY29tL3hhcC8xLjAvbW0vIiB4bWxuczpzdFJlZj0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL3NUeXBlL1Jlc291cmNlUmVmIyIgeG1wOkNyZWF0b3JUb29sPSJBZG9iZSBQaG90b3Nob3AgQ0MgKE1hY2ludG9zaCkiIHhtcE1NOkluc3RhbmNlSUQ9InhtcC5paWQ6MUQ5NjM5RjgxQUVEMTFFNEJBQTdGNTQwMjc5MTZDOTciIHhtcE1NOkRvY3VtZW50SUQ9InhtcC5kaWQ6MUQ5NjM5RjkxQUVEMTFFNEJBQTdGNTQwMjc5MTZDOTciPiA8eG1wTU06RGVyaXZlZEZyb20gc3RSZWY6aW5zdGFuY2VJRD0ieG1wLmlpZDoxRDk2MzlGNjFBRUQxMUU0QkFBN0Y1NDAyNzkxNkM5NyIgc3RSZWY6ZG9jdW1lbnRJRD0ieG1wLmRpZDoxRDk2MzlGNzFBRUQxMUU0QkFBN0Y1NDAyNzkxNkM5NyIvPiA8L3JkZjpEZXNjcmlwdGlvbj4gPC9yZGY6UkRGPiA8L3g6eG1wbWV0YT4gPD94cGFja2V0IGVuZD0iciI/PgH//v38+/r5+Pf29fTz8vHw7+7t7Ovq6ejn5uXk4+Lh4N/e3dzb2tnY19bV1NPS0dDPzs3My8rJyMfGxcTDwsHAv769vLu6ubi3trW0s7KxsK+urayrqqmop6alpKOioaCfnp2cm5qZmJeWlZSTkpGQj46NjIuKiYiHhoWEg4KBgH9+fXx7enl4d3Z1dHNycXBvbm1sa2ppaGdmZWRjYmFgX15dXFtaWVhXVlVUU1JRUE9OTUxLSklIR0ZFRENCQUA/Pj08Ozo5ODc2NTQzMjEwLy4tLCsqKSgnJiUkIyIhIB8eHRwbGhkYFxYVFBMSERAPDg0MCwoJCAcGBQQDAgEAACH5BAEAAAEALAAAAAABAAMAAAICRFIAOw==) repeat-y center top; font-family: 'Montserrat'; line-height: 1.5em; overflow: hidden; color: #000000; font-size: 16px; border-top: none; border-top-color: #666666; border-bottom: none; border-bottom-color: #3d3d3d; -webkit-box-shadow: none; -moz-box-shadow: none; box-shadow: none; clear: both; margin: 0px 0px; } .ck_form, .ck_form * { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; } #ck_subscribe_form { clear: both; } /* Element Queries — uses JS */ .ck_form_content, .ck_form_fields { width: 50%; float: left; padding: 5%; } .ck_form.ck_horizontal { } .ck_form_content { border-bottom: none; } .ck_form.ck_vertical { background: #fff; } .ck_vertical .ck_form_content, .ck_vertical .ck_form_fields { padding: 10%; width: 100%; float: none; } .ck_vertical .ck_form_content { border-bottom: 1px dotted #aaa; overflow: hidden; } /* Trigger the vertical layout with media queries as well */ @media all and (max-width: 499px) { .ck_form { background: #fff; } .ck_form_content, .ck_form_fields { padding: 10%; width: 100%; float: none; } .ck_form_content { border-bottom: 1px dotted #aaa; } } /* Content */ .ck_form_content h3 { margin: 0px 0px 0px; font-size: 0px; padding: 0px; } .ck_form_content p { font-size: 14px; } .ck_image { float: left; margin-right: 5px; } /* Form fields */ .ck_errorArea { display: none; } #ck_success_msg { padding: 10px 10px 0px; border: solid 1px #ddd; background: #eee; } .ck_label { font-size: 14px; font-weight: bold; } .ck_form input[type="text"] { font-size: 16px; text-align: center; margin-top: 20px; margin-bottom: 0px; padding: 8px 8px; width: 100%; border: 1px solid #d6d6d6; /* stroke */ -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ background-color: #fff; /* layer fill content */ height: auto; } .ck_form input[type="email"] { font-size: 16px; text-align: center; margin-top: 0px; margin-bottom: 15px; padding: 8px 8px; width: 100%; border: 1px solid #d6d6d6; /* stroke */ -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ background-color: #fff; /* layer fill content */ height: auto; } .ck_form input[type="text"]:focus, .ck_form input[type="email"]:focus { outline: none; border-color: #aaa; } .ck_checkbox { padding: 10px 0px 10px 20px; display: block; clear: both; } .ck_checkbox input.optIn { margin-left: -20px; margin-top: 0; } .ck_form .ck_opt_in_prompt { margin-left: 4px; } .ck_form .ck_opt_in_prompt p { display: inline; } .ck_form .ck_subscribe_button { width: 100%; color: #fff; margin: 0px 0px 0px; padding: 8px 8px; font-size: 18px; background: #c83232; -moz-border-radius: 4px; -webkit-border-radius: 4px; border-radius: 30px; /* border radius */ cursor: pointer; border: none; text-shadow: none; } .ck_form .ck_guarantee { color: #626262; font-size: 12px; text-align: center; padding: 5px 0px; display: block; } .ck_form .ck_powered_by { display: block; color: #aaa; } .ck_form .ck_powered_by:hover { display: block; color: #444; } .ck_converted_content { display: none; padding: 5%; background: #fff; } /* v6 */ .ck_form_v6 #ck_success_msg { padding: 0px 10px; } @media all and (max-width: 403px) { .ck_form_v6.ck_modal .ck_close_link { top: 30px; } } @media all and (min-width: 404px) and (max-width: 499px) { .ck_form_v6.ck_modal .ck_close_link { top: 57px; } }      Want More? 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Waters welcomes back Dr. Ewoud van Tricht where he builds on the last episode when he discussed how Janssen approaches vaccine development with analytical quality by design (AQbD). Today, he elaborates on the specific steps of AQbD and the advantages gained.

This week on 17 Minutes of Science we are joined by Dr. Alex Parker (Assistant Professor at University of Montréal, CHUM Research Center, CSO of Modelis). Dr. Parker has a broad background in genetics, with specific training and expertise in neuroscience, science of aging and hereditary diseases. He uses the model organism C. elegans to construct simple genetic models of these diseases and then confirms his findings in mice. Dr. Parker joins us to talk about how he uses multiple models in his research and how this stepwise approach is implemented at Modelis.

Every world in this realm is crisscrossed by ley lines; filaments of earth energy that connect places of worship, monuments, and historical sites. You have passed through innumerable ley lines in your life: think of any desolate place you have been where the hair on the back of your neck stood up for no reason you could fathom... Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 1 of 2. Written by: Jonathan Cohen Narrated by: Trevor Schechter A Faustian Nonsense production. To read the full transcript of this episode, go to https://thelavendertavern.captivate.fm/episode/myers-helping-hand-part-1 Transcript Every world in this realm is crisscrossed by ley lines; filaments of earth energy that connect places of worship, monuments, and historical sites. You have passed through innumerable ley lines in your life: think of any desolate place you have been where the hair on the back of your neck stood up for no reason you could fathom. The more ley lines that intersect in an area, the more magically powerful that area is. Some unfortunate towns only have a single ley line passing through – barely enough to allow a local mystic to dowse for water. Other towns are gifted with an abundance of ley lines. And of course, once the men and women of this world understood ley lines and how they could work to their advantage, they built towns and villages at the great crossroads of these lines. A mage might wander an unspoiled land, with enchanted spectacles on his nose, until he found a spot that burned with a grid of reddish-gold ley lines arcing across each other. Then he would send back word to those who had sponsored his expedition: here shall be a great city. There was one place where there were hundreds, perhaps thousands of ley lines that gathered and writhed like snakes. It was destiny that this should be the greatest city ever built. Those of temperaments sensitive to magic had already settled it as a village, but with the ley lines to power their efforts, it grew into a city of spires and minarets, columns and porticos. Frostford: The largest city in the known world. One cannot simply dip a wand or a staff into a ley line and extract the magic needed for a spell or incantation; it takes training and skill to handle the ley lines. It takes a Minister. And so, it came to pass, in a section of Frostford that was neither too poor nor too wealthy, that a young junior minister named Myer was late for his work. Myer was no more than twenty, with a shock of black wavy hair that never quite stayed where it should. He had hazel eyes and the babyish curious face of a child, and at this moment he stood among a pile of his clothes, looking for his staff. He could summon the staff, of course; this was a trifling cantrip for any minister. But Myer had nearly expended his allotment of magic for the thirty-days, and he did not want the Ministry to sanction him. Thomas would know where the staff was. But Thomas was not here, Myer thought. The staff was ebony. Why had he chosen ebony? With his black robes and furniture of dark wood, and black walls, the staff was nearly impossible to find. The only spot of light in his chambers was – And here he turned to his cat, Bedlam. Bedlam was officially a familiar, as far as the Ministry knew, but the luminous white cat with light green eyes, pink nose and ears spent his time sleeping or looking on with disdain. As Myer now saw, the cat had his paws wrapped around the ebony staff. “Give that to me!” Myer said, leaping for the cat. In a flash, Bedlam picked up the staff in his mouth and dropped it at Myer's feet. “Now,” Myer sighed. “Now you provide me with it after an hour of searching.” Bedlam looked up with innocent eyes and... Support this podcast

There was one place where there were hundreds, perhaps thousands of magical ley lines that gathered and writhed like snakes. It was destiny that this should be the greatest city ever built: Frostford. Meet Myer, an absentminded young mage who works for the Ministry in Frostford. Now meet Myer's helping hand: Stepwise, the daemon he creates so that he can find the things he misplaces. Myer is about to discover that giving humanity the ability to search for anything, at any time, can lead to catastrophe. Part 2 of 2. Written by: Jonathan Cohen Narrated by: Trevor Schechter A Faustian Nonsense production. To read the full transcript of this episode, go to https://thelavendertavern.captivate.fm/episode/myers-helping-hand-part-2 Transcript According to Myer's tracking spell, there were now nine Stepwises – eight of them outside of his control. Now it was time to panic. Myer tried to slow his breathing and thought of his lesson on Runaway Magic. How could he not think of it? It was the highlight of every Ministry student's first year of study. The magister who taught the course showed them how a magic spell that simply doubled objects would lead to disaster. He started with a copper coin and kept doubling it with a simple incantation. The single coin became two coins, then four, eight, sixteen, thirty-two, and by the tenth doubling the magister showered the podium in copper and told the students that there were now over a thousand coins…before he made all but one of them disappear with a flourish. Any magic that was not properly cast could lead to runaway magic. There were rumours that this was one of the reasons the Ministry had been formed in the first place, but the magister would neither confirm nor deny this. He had scraped the chalk across the large slate at the front of the class, then tapped each syllable, emphasizing the word: “Cat-tas-stro-phe!” Myer re-read the spell he'd written to conjure the first daemon. There were no flaws that he could see. No, Stepwise had been copied by human means, at least at first. He bit his lip. “Stepwise, double yourself,” he said with some dread. Stepwise stretched and split down the middle. Now there were two Stepwises in front of him. Eleven red spots on the line symbol. Cat-tas-stro-phe. He could duplicate enough Stepwises to catch the other Stepwises now, but since at least one other person knew how to duplicate the rogue daemons, there was no stopping them. And each daemon used a tiny bit of manna…unnoticeable at first, but once it became a case of Runaway Magic, the manna would start adding up. Myer was a clever young man. He often had many clever ideas and brought these clever ideas to Alastair or the lower magisters. This time, he felt that the cleverest thing he could do was to…say nothing. It would have been simple to deconstruct the Stepwises. All Myer needed to do to make them disappear was to reverse the spell inscribed on the sheet of parchment he now kept locked in the bottom drawer of his chest of drawers. He could even tear the parchment into pieces, if he did not mind the thought of every Stepwise suddenly deconstructing violently. But the moment Myer broke the spell, all of the accumulated manna that animated the daemons would instantly flow back into the manna reservoir at the end of the street, and from there into the neighborhood's ley line. The Ministry would not fail to notice an *increase* in the supply of manna…especially when a young, clever minister resided only a short walk away. The next morning Myer noted with a dull resignation that there were fourteen red dots on the symbol. On his walk to the Ministry, he spotted at least two Stepwises flitting about the buildings above him: one had a hammer in its mouth, and the other carried an apple. If Alastair suspected anything, he remained mute. Sueanna claimed to be busy with solstice preparations. Even Getty was busy with what he called “temple business.” Raven, Myer noticed, had started to Support this podcast

Stepwise Approach To Azoospermia --- Send in a voice message: https://anchor.fm/dr-richa-sharma/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.11.293670v1?rss=1 Authors: Plaskon, D., Henderson, K., Felth, L., Molzahn, C., Evensen, C., Dyke, S., Shkel, I., Record, T. Abstract: In transcription initiation, specific contacts between RNA polymerase (RNAP) and promoter DNA are disrupted as the RNA-DNA hybrid advances into the cleft, resulting in escape of RNAP. From the pattern of large and small rate constants for steps of initiation at {lambda}PR promoter at 19{degrees}C, we proposed that in-cleft interactions are disrupted in extending 3-mer to 5-mer RNA, -10 interactions are disrupted in extending 6-mer to 9-mer, and -35 interactions are disrupted in extending 10-mer to 11-mer, allowing RNAP to escape. Here we test this mechanism and determine enthalpic and entropic activation barriers of all steps from kinetic measurements at 25{degrees}C and 37{degrees}C. Initiation at 37{degrees}C differs significantly from expectations based on lower-temperature results. At low concentration of the second iNTP (UTP), synthesis of full-length RNA at 37{degrees}C is slower than at 25{degrees}C and no transient short RNA intermediates are observed, indicating a UTP-dependent bottleneck step early in the 37{degrees}C mechanism. Analysis reveals that the 37{degrees}C {lambda}PR OC (RPO) cannot initiate and must change conformation to a less-stable initiation complex (IC) capable of binding the iNTP. We find that IC is the primary {lambda}PR OC species below 25{degrees}C, and therefore conclude that IC must be the I3 intermediate in RPO formation. Surprisingly, Arrhenius activation energy barriers to five steps where RNAP-promoter in-cleft and -10 contacts are disrupted are much smaller than for other steps, including a negative barrier for the last of these steps. We interpret these striking effects as enthalpically-favorable, entropically-unfavorable, stepwise bubble collapse accompanying disruption of RNAP contacts. Copy rights belong to original authors. Visit the link for more info

This podcast presents, Dr. Patrick Carolan, a pediatric emergency medicine physician with Minneapolis Children's Hospital and Clinics of Minnesota, who discusses the evaluation of fever in the neonate and young infant.  Enjoy the podcast! Objectives:     Upon completion of this podcast, participants should be able to: Recognize the implications of fever in the young infant. Discuss the differential diagnosis of fever and critical illness in the young infant. Implement new concepts in risk stratification for evaluating fever in young infants. CME credit is only offered to Ridgeview Providers & Allied Health Staff for this podcast activity. Complete and submit the online evaluation form, after viewing the activity.  Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks.  You may contact the accredited provider with questions regarding this program at  rmccredentialing@ridgeviewmedical.org. Click on the following link for your CME credit: CME Evaluation: "The Approach to Fever in the Young Infant" (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.)  DISCLOSURE ANNOUNCEMENT  The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for CME/CE and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview Medical Center & Clinics.  Any re-reproduction of any of the materials presented would be infringement of copyright laws.  It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on these presentations. It remains for the audience to determine whether the speaker’s outside interest may reflect a possible bias, either the exposition or the conclusions presented. Ridgeview's CME planning committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. SHOW NOTES: CHAPTER 1: Today we are talking about fever in the pediatric population, specifically those in the under 3-months of age. Dr. Pat Carolan of Children's Hospitals of Minnesota  will help us demystify fever in this age group.  Going back to the mid-70s, there was a search for criteria to find high-risk vs low-risk pediatric fevers. In the original study out of Boston, it was identified that 10% of the patients under age 2, with WBC greater than 15, and a temperature greater than 38.9C, had severe bacteremia. This was the first set of criteria focused on identifying high-risk infants. With the intro of HIb vaccine in the the late 80s-early 90s, and the pneumococcal vaccine in the mid-90s, there is a much lower prevalence of these infections. The few cases that occur now are due to those who have not received or are non-responders to the vaccine. The shift in study of pediatrics has now been to better differentiate high-risk vs low-risk febrile infants. What is considered a fever? The traditional definition of fever is a temperature over 100.4F. Pediatric fevers can be broken down into 3 groups. Those in 0-28 days are high-risk and regardless of a positive RSV or influenza test, get a full work up - including blood, urine, csf, cultures, antibiotics, and admission.  What if they are 0-28 days and they have otitis media or RSV? The clinical exam of otitis media in this aged population would be difficult, and even if the clinician had confidence in a focal finding, those at this age group are still at significant risk and would get a full work up. RSV would be unusual in a 2-week old and even if positive , that would be an usual finding, and again these neonates would still get a full work up. The rates of bacteremia in studies have shown that a full work up is warranted. Infants at 3-months are lower-risk, and in general, can usually be managed as outpatients with lab work. Risk for infants in the 2nd month of life is harder to determine and they are the target of risk stratification tools discussed later in this podcast. These are the "tweeners". Initially, assessment of these infants include that across the room pediatric triage triangle. How are they reacting to stimulus? What does their skin color look like? What is their body tone? Have the parents noted whether the infant is engaged in feeding? Are they tachycardiac? Infants can present with fever, but some infants that are septic, can present afebrile or hypothermic. Remember, it is important not to overlook a potential differential diagnosis, including congenital ductal lesions or metabolic abnormalities. CHAPTER 2: Risk stratification tools vary, but utilize biomarkers such as procalcitonin and CRP as key features of the pathways. Each tool mentioned today, PECARN, Stepwise and Rochester, all have high sensitivity and high-negative predictive values. Choosing the appropriate tool depends on the patient population, ability to run specific biomarker tests, and comfort level in the subsequent interpretation. For example, the availability of a facility to run a procalcitonin would determine whether a particular stratification tool could be used. The most recent study, conducted by PECARN or the Pediatric Emergency Care Applied Research Network, is a large, multicenter study that uses procalcitonin, absolute neutrophil count and urine analysis as the base of its pathway. The PECARN is structured as a decision tree, formatted in a way, to quote Dr. Carolan that "helps decision making in the trenches." Differentiating between the terms "serious" vs "invasive" infections. Serious infections include, but are not limited to bacterial, bone and joint infections, and UTIs. Invasive includes pneumococcal meningitis and HIB. In the simplest terms, invasive infections are of greater concern, and is "the stuff we want to treat immediately". Bacterial organisms of concern include: group B strep and gram negative organisms for neonates, pneumococcus and more rarely, HIV at 1-month and older. E.Coli, especially as a uro pathogen and Listeria, though rarer, makes the list of concern as well. An important viral organism of concern is Herpes Simplex Virus, which depending on the facility, is an add on order when running CSF. HSV has 3 main types, the most devistating a CNS infection, which presents with fever and seizures - whether focal or generalized. Pleocytosis, or WBC greater than 16 in CSF, is abnormal in those less than 28-days of age. WBC greater than 10 is abnormal for 2-3 months of age. An absence of pleocytosis does not exclude a central nervous infection by HSV. CHAPTER 3: At 2-months of age, infants that meet low-risk criteria, can be treated as an outpatient - if next day follow-up can be assured. Conservative treatment for those with a UTI that have an abnormal urine and positive biomarker, would get blood cultures, LP and antibiotics. The odds ratio is low, but gram negative CNS infections can be devastating and require extended treatment of antibiotics. The stratification tools, PECARN, Stepwise, and Rochester, help guide practice for these 2-month old infants or "tweeners", but it can still be difficult to decide whether or not to do an LP. There is still a place for practitioner gestalt, and if something feels not quite right, an LP is appropriate. Some infants are brought to the ER with reports of a fever, but upon presentation are afebrile. If a rectal temp performed at home, then it is regarded as a true fever, and the age appropriate work up should be started. Empiric treatment for infants include: Ampicillin and Cefotaxime. Cefotaxime is the go to for 3rd generation cephalosporin, instead of Rocephin, which can cause a rise in bilirubin in young infants. For those under 3-weeks, Acyclovir coverage is added till HSV is ruled out. Vancomycin would be used for those beyond 2-weeks of life with pneumococcus or staph infection with sepsis. Tamiflu is started for infants with positive influenza greater than 2-weeks and under 2-years of age, per CDC recommendations. For those infants who are not vaccinated, the plan of care does not change for those under 3-months or greater that are vaccinated. Intuitively, it would be suggested that they are at higher risk, but there is little data bout this specific group. Thanks for listening.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.19.257477v1?rss=1 Authors: Elangovan, R., Soman, V., Kumari, S., Nath, S. Abstract: Many species of bacteria use flagella to navigate in its environment. The flagellum is a 7-10 m long helical filament with a rotary motor at its base embedded in the cell membrane and almost a dozen stator complexes. Proton motive force across the cell membrane powers the flagellar motors of E.coli and Salmonella. The motor stochastically switches between clockwise and counter-clockwise direction. A chemotaxis system causes the motor to change its direction, but the process is more complex as the switch is sensitive to load and proton motive force as well. NaCl is significant with regard to the flagellar motor as it affects the stator dynamics, proton motive force, and osmotaxis at higher concentration. Chemotaxis helps the bacteria for its growth and survival. E.coli's natural habitat has high osmolarity and the organism uses use various mechanisms for osmoregulation. However, the role of flagellar motor to adapt to the changes in osmolarity, or osmotaxis, is not well studied. In this work, we dissipated the membrane potential of bacteria in pH 7 using step-wise increase in concentration of NaCl in motility buffer and studied the output of E.coli's flagellar motor using tethered bead assay and swimming Salmonella enteritidis cells. We observed decrease in motor speed and switching rates with stepwise increase in NaCl concentration in the motility buffer. The mean speed of the motors decreased with NaCl concentration. The population of swimming cells tumbled more with increase in concentration of NaCl. At the single motor level, the motors biased to CCW rotation with decrease in membrane potential. In this study, we present our observations of the flagellar motor in high NaCl concentration, and explore how NaCl can be used to study various aspects of the bacterial flagellar motor. Copy rights belong to original authors. Visit the link for more info

Esta semana: Día 151 de cuarentena. Estamos de vacaciones, pero no los abandonamos. Disfruten del Live de la semana pasada, cuando Stepwise presento un set en vivo para la serie Reggae In The House de la familia de Produbzion & Reggae Live Festival de Mexico. 90 minutos de reggae, dancehall, plena, & afrobeats, exclusivamente para los oyentes del podcast. El video también sigue disponible en FB aquí: www.facebook.com/reggaelivefestival. Dale share ✊

Mel joins the show to chat about pain relief options during labour – she's a midwife, lactation consultant and trained NICU nurse.Mel chats about

I am making progress on my health and fitness journey! What is making the difference for me and how can you benefit? At our age, it is important to realize that our body and mind seeks homeostasis; that is the need to keep the conditions of your physical health in a state of "same old, same old." What has made the difference for me over the last 3 months (about 25 lbs, and better strength and endurance) is a stepwise approach that respects the systems and processes that are part of our physical make up. I'd love to hear how you are progressing!

I have recorded this podcast inspired by a gang from Gitam whom I met during a camping event in Araku. This Podcasts gives you a detailed analysis of - Important aspects to be considered before bunking a class - Stepwise process to initiate a mass bunk - About this gang and their sagas - A surprise at the end Hope it fills your 12 minutes 40 seconds with a smile on your face. If you want to support me and my content, Please check this link, https://www.patreon.com/samvedhvegi Drop your bunk stories on 9699611444 --- Support this podcast: https://anchor.fm/samvedh-vegi/support

Considering hormone replacement therapy or already testing out? Check out this smart Stepwise Approach with Karl Lambert. On this ep of Health Solutions with Shawn & Janet Needham... You'll Learn: • The difference between OPTIMAL and normal hormone levels • Which symptoms females with hormone imbalances experience • Why men are easier to treat for hormone imbalances • How doctors can use DNA testing to personalize your hormone replacement therapy • How estradiol can LOWER risks of cancer ~ Episode Resources... https://www.theredimediclinic.com https://www.facebook.com/RediMediClinicHouseCallPllc https://www.instagram.com/redimediclinic/ https://twitter.com/KLambert14 https://www.linkedin.com/in/karl-lambert-79978914/ ~ #HormoneReplacementTherapy #Menopause #ThyroidHealth #KarlLambert #RediMediClinic #ShawnNeedham #HealthSolutions #Estrogen #Hormone #HRT #Testosterone #ThyroidWarrior #ThyroidAwareness #MenopauseRelief #Progesterone #VitaminD3 #VitaminSupplements #ProstateCancer #BreastCancerAwareness #Estradiol #NeedhamHealthSolutions #TeamNeedham #HealthyActiveLife #ActivePeople #ActiveLifestyle #MosesLakeProfessionalPharmacy #MLRX #SickenedTheBook #ShawnNeedhamRPh #ThinkOutsideTheSystem #OptimalHealthMatters #ItsTime ~ ***#BenShapiro & #DaveRamsey Fans. Be in the driver's seat for your healthcare choices {not the system or doctors!}

After a brief hiatus, 30m returns with a fresh installment. DJ Stepwise steps up for episode 015, this time turning the dial back 25 years with an all-vinyl, mid-1990s ragga jungle selection. Similar to hip hop in America and baile funk in Brazil, jungle was a force in England’s inner cities in the early 90s. At a time when folks of color were relegated to the sidelines of the UK club scene, redemption came in the form of jungle music. Taking popular club sounds and interweaving them with their own cultural fabric, the 90s saw a significant shift in the UK rave scene, as black and brown producers began carving out a space for themselves in the white-dominated industry. Perhaps the most iconic example of this was ragga jungle, where reggae basslines and vocals were chopped and screwed alongside popular EDM beats of the day, creating a revolutionary soundtrack that was equal parts uptown and downtown. An avid “junglist” in the 90s, in this episode DJ Stepwise hand picks a choice selection of rare vinyl from his personal collection of original pressings – clicks, pops and all. Tracklist: DJ Nut Nut ft. Top Cat & Frankie Paul - Special Dedication (Ladies Mix) DJ Gunshot - Wheel’N’Deal Flytronix - Flystep Barrington Levy & Beenie Man - Under Mi Sensi (X Project Remix) Trinity - Gangsta Shy FX ft. Gunsmoke - Gangsta II (L Double Remix) Barrington Levy - Here I Come (Ridley Don Jungle Remix) Rude Bwoy Monty - Out In Da Streets Top Cat - Request the Style (Jungle Mix) UK Apache with Shy FX - Original Nuttah Red Light ft. Simpleton - Coca Cola Remix DJ Hype & Ganja Max - Rinse Out ft. MC Fats & DJ Daddy Lo-Key - Shot Fe Bust Capone - Massive DJ Rap - Intelligent Woman Link DJ Stepwise here:www.stepwisedj.com www.instagram.com/stepwisedj www.galanginternational.com www.facebook.com/stepgalang www.twitter.com/stepwisedj ⚡️⚡️⚡️ 30m: High quality DJ mixes, always thirty minutes long. Subscribe for more shows. Join the movement, tag us: #30mPodcast.

The gang discusses two papers that look at how the morphology of tetrapods (animals with four limbs and a backbone) has changed over time. One paper looks at how dinosaur jaws are related to diet preferences, and the other paper looks at how spines have changed as tetrapods diversified through time. Meanwhile, James talks Star Trek, Curt gives some consumer advice, and Amanda would rather not talk about cowboys.   Up-Goer Five (James Edition): This week the group look at two papers that are looking at different ways that animals get more different. The first paper is looking at the mouths of big angry animals with no hair. The big angry animals with no hair that eat other animals and get big have the least different mouths from each other, but those that are small and eat other animals have very different mouths from one another, and those that eat living things that make their own food or both other animals and living things that make their own food have the most different mouths from one another. We see the same thing no matter how we decide how different mouths are. The other paper is looking at the line of hard bits in the back of animals that do have hair to see if they get more different over time and do different things along the same line of hard bits. We find out that the line of hard bits do get more different over time, and that the reason they get more different may be because the animals with hair start to breathe more air.   References:  Jones, Katrina E., Kenneth D. Angielczyk, and Stephanie E. Pierce. "Stepwise shifts underlie evolutionary trends in morphological complexity of the mammalian vertebral column." Nature communications 10 (2019).   Schaeffer, Joep, et al. "Morphological disparity in theropod jaws: comparing discrete characters and geometric morphometrics." Palaeontology (2019). 

Stacey Mosley is the Co-founder and CEO of Stepwise, a startup that empowers real estate investors to quickly find and evaluate investment opportunities. Prior to launching Stepwise in 2015, Stacey worked for the City of Philadelphia for five years practicing data science for the City’s Vacant Property Strategy and Open Data initiative. Before that, she worked for a promising local startup. But after she was suddenly laid off and without a job, she started wandering around Philly, looking for her next career step. It was then that she started noticing all the abandoned homes and vacant lots. She started working for the City of Philadelphia's Department of Licenses & Inspections, and experienced firsthand the tragedy of the 2013 Market Street Building Collapse. With a desire to use data to impact Philly life, Stacey would later go on to cofound Stepwise. Now, she knows before everyone else which neighborhoods are next to see immense development, and everything that comes with it. Support Philly Who? Donate via Paypal, Venmo: @podphillywho, Become a Monthly Patron, Purchase a T-Shirt or Hat, Become a Sponsor

In this episode of StepWise, we break from the normal question breakdown to go over what I think is the best way to study for Step One. It essentially breaks down to, Use a QBank like Pastest etc, to help study during classes. Use Anki throughout to memorize the details. Use Pathoma and Sketchy for … Continue reading Episode 15: Step One Study Strategy →

In this episode of StepWise we breakdown a GI question that at first, may seem to be very involved, but once we figure out what is actually going on is easily solvable! You can reach me at Trey@StepWisepodcast.com Pastest website: Pastest.com Take things one Step at a time!  

In this episode after Boyd talks about what holds us all back… Comfort. It is not only until we get to a point where we are in enough pain to change that we can do so. Stepwise we can build whatever we want in our life as long as we are willing to do what is required. This is truth folks!

Dubophonic Records is a forward thinking independent music label based in Cyprus, providing exclusive releases of dub music, from artists who are dedicated and passionate about their work. Founded in 2013, the label retains focus on the art of dub music in its most diverse forms, whether it is electronic or acoustic/organic, roots or steppers, classic or contemporary, defining the outer boundaries of dub music. The podcast showcases the works of the label!

Dubophonic Records is a forward thinking independent music label based in Cyprus, providing exclusive releases of dub music, from artists who are dedicated and passionate about their work. Founded in 2013, the label retains focus on the art of dub music in its most diverse forms, whether it is electronic or acoustic/organic, roots or steppers, classic or contemporary, defining the outer boundaries of dub music. The podcast showcases the works of the label!

On this episode of StepWise we break down an anemia question and discuss how to rule in and out different etiologies so you have an approach to anemia questions on Step One! You can contact me at trey@stepwisepodcast.com Find pastest at www.pastest.com

In this episode we break down a question over lipid lowering agents and there is a bonus section at the end where we go over the different lipid lowering drugs to hit the highlight of what you should know about them to succeed on Step One. If you have any Questions, Comments, Suggestions, or Topic … Continue reading StepWise Episode 8: A Lipid Lowering Agent Question →

In this episode of StepWise we solve a question dealing with anticoagulation medications in the setting of a patient experiencing a PE. Highly relevant in Step One and real life. You can find Pastest by Pastest.com You can contact me at Trey@stepwisepodcast.com or @stepwisepodcast on twitter

The contributions of immigrant communities the world over have been a hot topic as of late (thanks France ⚽️

DJ Stepwise returns for the second installment of 30m: Baile Funk (002). This episode delivers a blend of classic and future Baile Funk/Funk Carioca music from Brazil, with enough remixes to almost make it sound familiar. Mixed on turntables, #syncfree. For more from Stepwise, visit his website at www.stepwisedj.com.Tracklist:MC João - Baile de Favela Mcs Leleto e Maromba - Automaticamente $hirak ft. SBMG - Beng ($edajo Baile Funk Mix) Marginal Men x King Kong x DJ R7 - Damaia MC Fioti - Bum Bum Tam Tam (Mastiksoul Bootleg) Mastiksoul - Senta No Pula Pula (2018 Kapote Rmx) Rae Sremmurd - No Flex Zone (Sydney Sousa Refix) Mano DJ, Baauer & Marginal Men ft Cardi B & Mr Catra - Bodak Yellow (Versão Funk 2018) Migos ft. MC Bin Laden - Bad and Boujee (DJ Stepwise Favela Remix) Mc Bin Laden - Bololo Haha (Uproot Andy Champeta Edit) Vlien Boy - Da Pika Daniel Haaksman - Toma Que Toma (DJ Jesus Lopez Eu Quero Putaria Remix) Major Lazer ft. The Partysquad - Original Don (Broda Baile Funk Remix) Neném - Ja Peguei Menor Da Provi - Nheka Nheka DJ Sandrinho - Berimbau Duda do Borel - Quem Mora no Morro MC´s Coelho & Dinho - Cria da Favela MC G15 - Deu Onda MC G15 - Deu Onda (Phon4zo Remix) Future - Karate Chop (Mr. Digital Baile Funk Remix) Dillon Francis - Say Less (Sydney Sousa Baile Funk Edit) Omulu + King Doudou - Baile Saboroso (Daniel Haaksman Edit) DKVPZ - Menina Cardosu - Remember? ⚡️⚡️⚡️30m: High quality DJ mixes, always thirty minutes long. Subscribe to hear hand-crafted, exclusive mixes from internationally renown DJs. All styles. Curated by DJ Stepwise. Join the movement, tag us: #30mDJmixes

Galang Radio's DJ Stepwise from Argentina/California delivers the first installment of 30m, Tropical Bass. File under: dancefloor remixes from the tropics. Mixed on turntables, #syncfree. For more from Stepwise, visit his website at www.stepwisedj.com. Tracklist:E-40 & Nicky William - Snap Ya Riddim (DJ Baysik Edit) Jamie XX - Good Times ft Young Thug & Popcaan (J Boogie EDIT) Kid Ink ft Ty Dolla $ign - F With U (Flrivn & Nikki X Remix) The Weeknd & Daft Punk - Starboy (DJ Break Club Mix) Shabba Ranks - Trailer Load Of Girls (DJ Inko Remix) Eshconinco ft El Tachi & Yemil - Good Gyal Moombahton Remix Farruko ft.Bad Bunny, Nicki & 21 Savage - Krippy Kush (DJ Baysik Club Edit) Thornato - Rhinoceros ft Gappy Ranks (Poirier Remix) Ape Drums - Deva (DJ Baysik VIP) Fasta ft G-reat - Makaku Rhythm Fasta ft Ameiro - Body Brukka Fasta ft Ameiro - Waya Ding Mr Saik ft Akim - La Rusa Offset ft. Metro Boomin x Gualtiero - Ric Flair Drip (DJ Baysik w/Drop Bootleg) Justo Betancourt - Cataño (Whiskey Barons Cumbia Dub Mix) Joe Arroyo - La Rebelión (Disque Dj Remix) El Dusty - K Le Pasa (So Shifty Remix) Orquesta Colon - Pedro Simon (Dos Melo Edit) Dicky Ranking - Baile de un Pie Dicky Ranking - Sancocho Jey D - Contra La Pared DJ Seb.B & Black T - Michto Popeye Caution - Work Mash Up International - Waistline Ting (feat. Shenseea) ⚡️⚡️⚡️ 30m: High quality DJ mixes, always thirty minutes long. Subscribe to hear hand-crafted, exclusive mixes from internationally renown DJs. All styles. Curated by DJ Stepwise. Join the movement, tag us: #30mDJmixes

Knock the wind out of asthma with tips from Dr Denitza Blagev, a pulmonologist and intensivist who currently serves as Director for the Schmidt Chest Clinic at Intermountain Medical Center in Murray, Utah. We simplify the approach to diagnosis, spirometry, patient counseling, choice of agent, stepwise therapy, and de-escalation...plus, a little myth busting. Special thanks to Dr Cyrus Askin for writing and producing this episode and to Dr Bryan Brown for his wonderful infographics. Full show notes available at http://thecurbsiders.com/podcast Join our mailing list and receive a PDF copy of our show notes every Monday. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com.  Time Stamps 00:00 Disclaimer 00:32 Intro 01:44 Picks of the week 04:38 Guest bio 06:20 Getting to know our guest 11:50 Clinical case and approach to the patient with dyspnea 16:38 How to explain asthma to a patient 17:22 Are PFTs needed for diagnosis and management of asthma? 18:44 Methacholine challenge and who needs one 21:15 Is imaging needed? 22:09 Typical PFT patterns in asthma 24:23 Utility and use of peak expiratory flows 25:45 Cough variant asthma 26:34 Physical exam in patient with asthma 27:45 Lab workup 29:07 Initial treatment and inhaler teaching 33:10 Stepwise therapy for asthma 37:27 De-escalation of therapy 39:18 Levalbuterol versus albuterol 40:20 Asthma action plans 43:06 Who needs a sputum sample 45:25 How to treat asthma exacerbations 48:05 Asthma therapy for hospitalized patients 51:10 Azithromycin and asthma 53:40 Who needs a referral 55:24 Are beta blockers safe in asthma? 56:08 Anticholinergic therapy and asthma 57:26 Take home points 58:58 Paul tells a story about asthma 59:55 Outro  Tags: asthma, inhaler, teaching, eosinophilia, albuterol, cough, variant, methacholine, spirometry, xray, pft, peak, flow, fev1, sputum, step, laba, lama, beta, agonist, azithromycin, symptoms, steroids, assistant, care, education, doctor, family, foam, foamed, health, hospitalist, hospital, internal, internist, nurse, meded, medical, medicine, practitioner, professional, primary, physician, resident, student

Melissa McCool is the co-founder and CEO of Stellicare Corporation. In 2009, Melissa developed Symptom Targeted Intervention (STI), a clinical program used in thousands of US medical clinics to improve the behavioral determinants of health. Since then, she has written and produced numerous articles, videos, and books and has trained thousands of clinicians around the US and Canada on how to implement STI into clinical practice. Melissa is also an EMDR-trained psychotherapist with a specialization in treating trauma. Her degrees are from UCSD and Columbia University. 00:00 Patient Adherence - Why Patients don't adhere. 03:45 Patient fears. 05:45 Normalizing Patient fears. 07:15 Figuring out the more effective and less effective ways of addressing underlying emotions driving patient behavior. 08:30 What else drives Patient Behavior. 10:50 How the 80/20 Rule changes with Value-Based Care. 12:00 Patient Behavior Problems. 15:00 “I didn't focus on what I thought the patient needed to change, I asked the patient what they thought they needed to work on.” 18:00 Reducing Stress and Improving Adherence. 19:00 The domino effect with Patient Behavior. 21:00 Helping Patients in five minute increments. 23:40 Quality Indicators and A1Cs. 26:30 “Moving the needle,” with “the 20%”. 28:00 Messaging according to Patient Engagement. 30:00 “Our instinct is to work with sweet, cooperative patients.”

Barry Murray is a sports nutritionist and member of the Irish Ultramarathon Team currently working with Pro Tour cyclists. Barry has won several ultra-distance (70-200 km) running races, The Mourne Mountain Way, The Abbots Way, The Giants Causeway, The Wicklow Way, The Kerry Way, all without eating anything for breakfast. How? In a word, fat-adaptation. In this interview, Barry describes his work with the pros and six much overlooked factors for high-performance ultra-endurance training: sunlight, cold thermogenesis, DHA from seafood, grounding, and water quality. Here’s the outline of this interview with Barry Murray: [00:01:56] BMC Racing Team. [00:02:06] Ultramarathon. [00:05:39] Low-carb, high-fat, ketogenic. [00:06:14] Fasted state training. [00:07:16] Sirtuins. [00:12:38] AMP kinase. [00:13:35] Beta-oxidation. [00:13:44] Mitochondrial biogenesis. [00:15:20] Acetyl-CoA. [00:15:38] Peter Attia, MD. [00:16:03] Stepwise adaptation. [00:18:38] What are the pro cyclists doing? [00:19:35] Nutrition is the new doping. [00:23:00] Team Sky. [00:23:55] Steve Cummins. [00:24:29] 2-3 years to adapt. [00:26:00] Can be done in 6-12 months. [00:27:04] Train low, race high. [00:28:26] Rates of brain glucose use. [00:29:30] Pyruvate dehydrogenase. [00:30:34] Ketone MonoEster article. [00:31:21] Are the pros using ketone supplements? [00:32:05] Chris Froome. [00:32:33] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268. [00:34:00] Beta-oxidation is the goal, not ketogenesis. [00:35:16] Jack Kruse. [00:37:11] Six things to optimal health and living. [00:37:30] Sunlight. [00:37:53] Cold thermogenesis. [00:38:05] Seafood. [00:38:18] Grounding. [00:38:25] Non-fluoridated water. [00:39:55] UVB tanning booths. [00:40:37] Schumann resonance. [00:41:38] Electron Transport Chain (ETC) [00:43:44] Sven Tuft of Orica Bike Exchange. [00:44:45] Wim Hof. [00:45:30] Kox, Matthijs, et al. "Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans." Proceedings of the National Academy of Sciences 111.20 (2014): 7379-7384. [00:48:28] http://optimumnutrition4sport.co.uk/ [00:48:56] Fasted State Training Adaptations Jack Kruse forum post.

Today we host Dr. Hossam Zawawi and Fayez Milibari. Hossam tells about his amazing story of discovering previously unknown organisms deep inside a previously untouched cave. Show Links Saudi Channel 2 Old Logo Riyadh's TV Tower Steve Jobs is Now in the Photography Hall of Fame How to properly wash your hands Louis Pasteur We are more bacteria than human? Triclosan FDA bans antibacterial soaps; “No scientific evidence” they're safe, effective Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae Penicillin: An accidental discovery changed the course of medicine Inside the lost cave world of the Amazon's tepui mountains The Darwin Awards

Today we host Dr. Hossam Zawawi and Fayez Milibari. Hossam tells about his amazing story of discovering previously unknown organisms deep inside a previously untouched cave. Show Links Saudi Channel 2 Old Logo Riyadh's TV Tower Steve Jobs is Now in the Photography Hall of Fame How to properly wash your hands Louis Pasteur We are more bacteria than human? Triclosan FDA bans antibacterial soaps; “No scientific evidence” they're safe, effective Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae Penicillin: An accidental discovery changed the course of medicine Inside the lost cave world of the Amazon's tepui mountains The Darwin Awards

Margaret Parker, MD, MCCM, speaks with Nilesh M. Mehta

Margaret Parker, MD, MCCM, speaks with Nilesh M. Mehta

Download Audio File After a fluid is deposited onto a substrate anything can happen. While the fluid is balancing on the substrate and traveling to the curing section of the process, what will the fluid do? In this gap between the coating phenomena and the final cured state, the [...]

Summer's rollin' up on us this month, and just to make sure we get it started right, we brought in an expert. For June, San Francisco's Stepwise comes correct with a collection of his own exclusive dancehall remixes. This Argentinian-born DJ/producer has been spinning records for the last decade, played just about everywhere there is to play in SF, lived in Australia for two years (where he held down three weeklies), and is now back in the Bay representing Audiopharmacy (respect). You can hear more when the official mix CD drops (REmix 101, due late June), and be on the look for Stepwise remix 45's (in stores now). Nuff live dates too, including June 24 at the Canvas Gallery with Daneekah, Jocelyn (mk007 coming next month), DJ SpaceInvader, Sixtwentyone, and Adegen. More info will posted about that event soon. For epsiode 6, Stepwise gives us a sneak preview of what's coming up when that mix CD drops, with 24 big, 808-heavy, crunky as hell remixes of top dancehall cuts from Vybz Cartel, Buju Banton, Capleton, and more. Ruckus. memekast mk006 » June 2006 » Stepwise 1. Ras Attitude Intro David Banner - Play 2. Left Side + Esco - Tuck In Yuh Belly 3. Vybz Cartel - Tight Gal Shawnna - Gettin Some Head 4. Shabba Ranks + Mykal Rose - Shine Eye Gal 5. Capleton - Dem A Bait 6. Shabba reprise Chris Brown - Gimme That 7. Jr Reid + Mobile Malachi - Put Down the Gun 8. Lexxus interlude Nukie Riddim 9. G-Unit - Poppin Them Thangs 10. Natty King - Awake 11. Buju Banton - Legalize It Rihanna - If It's Lovin That You Want pt. 2 12. Capleton - Mi Food 13. Vybz Cartel - Sen On Craig Mack - I'll Spend Dat 14. I'll Spend Dat 15. Wayne Marshall + Assassin + Ele + Vybz - Weed Smoke The Team - Hyphy Juice 16. Hyphy Juice 17. Buju Banton - Sha-La-La Bun B - Git It 18. Ding Down - Bad Man Forward Bad Man Pull Up 19. Buju Banton - People Kill People 20. Sizzla - I Was Born E-40 - U and Dat 21. U and Dat 22. Mr Vegas - She's a Ho 23. Lexxus - Video Light/Bounce A Gal 24. U and Dat Outro.... » stepwisedj.com » stepwise @ myspace memekast_mk006_200606.mp3

Kalyanam and Shively (1998) and van Heerde et al. (2001) have proposed semiparametric models to estimate the influence of price promotions on brand sales, and both obtained superior performance for their models compared to strictly parametric modeling. Following these researchers, we suggest another semiparametric framework which is based on penalized B-splines to analyze sales promotion effects flexibly. Unlike these researchers, we introduce a stepwise procedure with simultaneous smoothing parameter choice for variable selection. Applying this stepwise routine enables us to deal with product categories with many competitive items without imposing restrictions on the competitive market structure in advance. We illustrate the new methodology in an empirical application using weekly store-level scanner data.

The assumption that stationary hotspots underlie the Earth’s lithospheric plates has been most important in the development of the theory of plate tectonics. According to the fixed hotspot hypothesis seamount trails are formed by volcanism penetrating the lithospheric plates whilst moving over ”hotspots”of upwelling mantle. In turn, the azimuths and age progressions of seamount trails can be used to quantify plate motions with respect to an independent reference frame of hotspots in the mantle. Also, assuming fixed hotspots, the direction of characteristic remanent magnetization in the basalts acquired during cooling should always be the same. Even if due to plate motion the products of the hotspot are located far away from the position of the hotspot itself, paleomagnetic studies on the basalts must always provide the position of the hotspot itself. Recently the question arose, why a hotspot with its origin deep in the mantle would not get advected in the convecting mantle of the Earth. - In this thesis a possible motion of the Kerguelen hotspot in the southern Indian Ocean and of the Louisville hotspot in the Pacific has been studied. The Kerguelen hotspot is active since approximately 117 Ma. Since then it formed the Kerguelen Plateau and the Broken Ridge in the southern Indian Ocean as well as the Ninetyeast Ridge, which is the hotspot track going north up to India, and the Ramajal Traps in India. Drilling into basement rocks of Broken Ridge and the Kerguelen Plateau was aim of the Ocean Drilling Program, Leg 183, from December 1998 to February 1999. Eight sites have been drilled. In seven of the sites also the sediments have been recovered. In this thesis, a possible motion of the Kerguelen hotspot has been studied by determining its paleolatitudes. First, basalts from the Kerguelen Plateau have been studied paleomagnetically to compare the paleolatitudes with the latitude of the hotspot itself. Basement from a drillsite on the central Kerguelen Plateau (Site 1138) and of a site on the northern Kerguelen Plateau (Site 1140) were suitable for a determination of paleolatitudes. A sufficient number of independent lavaflows has been penetrated and sampled there to properly average out paleosecular variation, an important requirement for determining paleolatitudes. The characteristic magnetization from the subaerial Site 1138 with AA- and Pahoehoe lava and of the submarine Site 1140 with its pillow basalts is carried by magnetite and titanomagnetites and -maghemites and consists of a single remanence component with sometimes a small viscous overprint, that could easily be removed during demagnetization. Stepwise demagnetization in an alternating field and stepwise heating of the specimens provided the inclination value of the characteristic magnetization very precisely with small error. Conversion of the mean-site inclination into the paleolatitude of a site provided a latitude of λ = 43.6◦S (max.: 47.8◦S; min.: 37.9◦S) for Site 1138 on the central Kerguelen Plateau and a latitude of λ = 35.8◦S (max: 43.0◦S; min.: 28.9◦S) for Site 1140 on the northern Kerguelen Plateau. In Site 1136 on the southern Kerguelen Plateau only two lava flows have been sampled. Therefore paleosecular variation could not be averaged out properly. Site 1142 on the Broken Ridge has been tilted and deformed tectonically after its formation, as was found from seismic explorations prior to drilling, and the inclination of the magnetization could therefore not be used for a determination of paleolatitudes. Compared to the latitude of the Kerguelen hotspot at 49◦S, the paleolatitudes of the central and northern Kerguelen Plateau are further north. This result agrees with previous paleomagnetic studies on the southern Kerguelen Plateau and the Ninetyeast Ridge, where paleolatitudes have been found that indicate also a formation north of the present-day hotspot position. This difference indicates a southward movement of the hotspot since the Cretaceous relative to the spin axis of the Earth. The motion can be explained with a rotation of the whole mantle of the Earth relative to the spin axis (true polar wander) or with a motion of the hotspot within the Earth’s mantle. Therefore, the possibility was studied whether true polar wander can be responsible for the difference between the paleomagnetic data and the present-day latitude of the hotspot. Three independently obtained true polar wander paths have been used, that describe the motion of the whole mantle (with the hotspots) relative to the rotation or dipole axis. All three curves point to a shift of the mantle at the time when the central and southern Kerguelen Plateau formed in such a way that higher southern paleolatitudes should be observed. This prediction is just the opposite to what was found in the paleomagnetic studies. The Cenozoic parts of the three experimentally obtained true polar wander paths roughly agree within their uncertainties with a numerically calculated path that accounts for changes of moments of inertia of the mantle. This means that the difference between paleomagnetic data and the present-day position of the hotspot can not be explained by true polar wander. The next starting point to explain the discrepancy is hotspot motion. For the determination of hotspot drift, geodynamic modeling has been carried out. Assuming that a mantle plume rising from the core-mantle boundary is advected in an convecting mantle, a hotspot sould move relative to the surface of the Earth. Seismic tomography models were converted into density models of the Earth’s mantle. Then a velocity field derived from the mass motion due to the density heterogeneities is calculated. The rising mantle plume is then inserted into the model and becomes advected in the velocity field. Seven different tomographic models have been used to obtain velocity fields. All seven models result in a southward motion for the Kerguelen hotspot since its first appearance approximately 117 Ma ago. The motion is in a similar direction for the different models, and its magnitude varies from 5 to over 10 degrees. So far, the program to model the hotspot drift assumed a constant viscosity within the rising plume. More realistic is the assumption of a depth-dependent plume radius, based on estimates of temperature- and hence viscosity variations within the plume. This has been integrated as a subroutine into the program. The plume radius affects the buoyancy of the plume. A plume with larger radius rises faster through the mantle, and will hence have a stronger tendency to straighten up. In contrast, a plume with smaller radius rises slowly and will be influenced more strongly by the velocity field of the mantle. Allowing for the variation of viscosity within the plume, the hotspot motion was calculated again. A comparison of the resulting hotspot motion for various input parameters showed that the result is rather independent of the parameters. The calculations also yield a southward motion of 5 to 10 degrees, only the shape of the hotspot path is somewhat changed. This southward motion of the Kerguelen hotspot by 5 to 10 degrees can explain the difference between the paleomagnetic data and the present-day position of the hotspot. Even combined with true polar wander it fits the paleomagnetic results, although true polar wander, taken by itself, even increases the difference that has to be explained. The consistency of paleomagnetic results with the model calculations allows the conclusion that the Kerguelen hotspot indeed moved southward by some degrees since its first occurence 117 Ma ago. A magnetostratigraphy has been made using the sediments of ODP Leg 183. It yielded a contribution to the age dating of the basalts prior to 40Ar/39Ar dating. Paleomagnetic studies on the sediments contributed to a combined Bio/Magnetostratigraphy. The stratigraphy helps to determine the minimal age of the underlying basalts. Using the reversals found in the magnetization and a correlation with the paleontological data, the lowermost sediments of Site 1136 (southern Kerguelen Plateau) are dated to have an age in the Early Cretaceous, Site 1138 (central Kerguelen Plateau) in the Late Cretaceous, and Site 1140 (northern Kerguelen Plateau) in the Oligocene. These results are meanwhile confirmed by precise 40Ar/39Ar age dating of the basement yielding an age of 100 Ma for Site 1138 and of 35 Ma for Site 1140. The Ontong Java Plateau, a Large Igneous Province in the western Pacific, was thought to be formed by the rising mantle plume of the Louisville hotspot approximately 120 Ma ago. However, according to a recent plate reconstruction, the plateau has been formed well to the north of the location of this hotspot. In this thesis it could be shown that the formation of the Ontong Java Plateau by the Louisville hotspot is possible if hotspot motion in the convecting mantle is allowed. For this purpose, the motion of the Louisville hotspot for the last 120 Ma years has been modeled, using the same method as already applied for the Kerguelen hotspot. The calculations indicate, that the Louisville hotspot has probably shifted by some degrees to the south since its first occurence approximately 120 Ma ago. There is a considerable variation between different model results, though. The Louisville hotspot is now located too far south to be responsible for the formation of the Plateau. However, it could have been in the right place at the time of the formation 120 Ma ago if hotspot motion is considered. This is an example that the drift of hotspots can affect plate tectonics and tectonic reconstructions and that it should be considered.

The 1,3-diphenyl-2-azaallyl anion (1) undergoes [3 + 2] cycloaddition reactions with the s-cis-fixed 1,3-dienes 8-11. In contrast, 1,1,2,2,3,3-hexamethyl-4,5-bis(methylene)cyclopentane (7) reacts with 1 to give the [4 + 3] cycloadduct 13 and the linear 1,4-addition product 14. This reaction is four orders of magnitude slower than the corresponding reaction of 1 with 1,2-bis(methylene)cyclopentane (8), which exclusively yields [3 + 2] cycloadducts. A change of mechanism - concerted cycloaddition of 8 and stepwise cycloaddition of 7 - is suggested, but not unequivocally proven. It is concluded that reactions of 1 with ordinary dienes cannot profit from concertedness by more than 5 kcal · mol-1.

Sun, 1 Jan 1989 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3830/ http://epub.ub.uni-muenchen.de/3830/1/093.pdf Baran, Janusz; Mayr, Herbert; Ruster, Volker; Klärner, Frank Gerrit Baran, Janusz; Mayr, Herbert; Ruster, Volker und Klärner, Frank Gerrit (1989): Stepwise [4 + 2]- and [4 + 4]-cyclodimerizations of 1,1,2,2,3,3-hexamethyl-4,5-bis(methylene)cyclopentane. In: Journal of Organic Chemistry, Vol. 54, Nr. 21: pp. 5016-5019.

Sat, 1 Jan 1983 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3793/ http://epub.ub.uni-muenchen.de/3793/1/033.pdf Mayr, Herbert; Bäuml, Englbert Mayr, Herbert und Bäuml, Englbert (1983): Concerted [4+2] and stepwise [2+2]cycloadditions of the triphenylallenyl cation with cyclopentadiene. In: Tetrahedron Letters, Vol. 24, Nr. 4: pp. 357-360.

Thu, 1 Jan 1981 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3819/ http://epub.ub.uni-muenchen.de/3819/1/020.pdf Mayr, Herbert; Seitz, Brigitte; Halberstadt-Kausch, Inge K. Mayr, Herbert; Seitz, Brigitte und Halberstadt-Kausch, Inge K. (1981): Stepwise [2 + 2] and [3 + 2] "cycloaddition" reactions of allenyl cations with olefins. In: Journal of Organic Chemistry, Vol. 46, Nr. 5: pp. 1041-1043. Chemi

Notes on Justin Welsh * Grown staff from 50 to 400 in 2.5 years * From $5 million in recurring revenue to $50 million per year * PatientPop: It's like HubSpot for doctors * Once you have a consistent sales process you know you're onto something * Listen to your customers. Review the NPS responses. * Understand how your prospects and clients learn * Be stern in your recommendations * They educate their marketplace * Leverage channel partners * You need to warm up the market with good educational content * Aware and educate on the solution once they raise their hands * Get in the weeds to show the prospect how it works * Know how your clients buy. * 8.6 day sales cycle but they do detailed demos. * 105 in sales so about 25% of the company * Sales development reps * Inside sales * Partner sales * Field sales * Follows the leader like Mark Roberge in how he finds top sales talent * Also looks at "action over academia" * Move fast. Be accountable. * Likes to find talent that is happy where they are and killing it * He's a big fan of having good recruiters * Inside is "tribal training" with a fast start in the first two weeks then ongoing with metrics at 30, 60, 90 days * "Top performers should rob from bottom" so he's commission-heavy * PPC is still effective for reaching physicians * Always experiment with your marketing processes * Grow your team into their roles (Stepwise growth) * He hires smart, young people right out of school and bring them up with a gradual progression * Confidence comes with experience, not just age * Sales enablement person is Sandler trained but they focus on "company training" first * Sell your people on your company and your customers * His AEs sell as well as coach and mentor with a pod system Get all of the show notes for every episode of The Sales Podcast ( https://www.thesaleswhisperer.com/podcasts/ ) with Wes Schaeffer, The Sales Whisperer® ( https://www.thesaleswhisperer.com/ ). Use these resources to grow your sales: * Sell More This Month ( https://www.thesaleswhisperer.com/30-day-sales-growth ) * Hire Better Salespeople ( https://talentgenius.simplybook.me/v2/ ) * Hire The Best Keynote Speaker ( https://www.wesschaeffer.com/ ) * Find Your Best CRM ( https://info.thesaleswhisperer.com/best-crm-quiz ) * Join the Free Facebook Group ( https://www.facebook.com/groups/theimplementors/ ) Check out early episodes of The Sales Podcast: * Episodes 1 to 10 ( https://www.thesaleswhisperer.com/blog/sales-podcast-episodes-one-to-ten ). * Episodes 11 to 20 ( https://www.thesaleswhisperer.com/blog/the-sales-podcast-episodes-11-20 ). * Episodes 21 to 30 ( https://www.thesaleswhisperer.com/blog/sales-podcast-episodes-21-30 ). * Episodes 31 to 40 ( https://www.thesaleswhisperer.com/blog/sales-podcast-episodes-31-40 ). Support this podcast at — https://redcircle.com/the-sales-podcast/exclusive-content Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy