Podcasts about Attenuation

In this special episode recorded at the recent Craft Beer & Brewing Brewer's Retreat (https://www.brewersretreat.com/) at Dogfish Head in Milton, Delaware, Khris Johnson of Green Bench (St. Petersburg, Florida), Doug Reiser of Burial (Asheville, North Carolina), and Vinnie Cilurzo of Russian River (Windsor, California) share their answers to attendees' questions about brewing IPA—focusing on the American and West Coast styles. Along the way, they discuss: using flowable hop products from Yakima Chief Hops, Abstrax, Haas, Steiner, and others reducing green matter to lengthen beer's packaged lifespan optimizing for early presentation in package building body in high-attenuation IPAs taking a balanced approach to chloride and sulfate bumping sodium through water softening to increase savoriness unsung hops that provide big impact adjusting pH to alter the character of bitterness brewing black IPA or Cascadian dark ale Using pH to manage hop creep And more. This episode is brought to you by: G&D Chillers (https://gdchillers.com): At G&D Chillers they always strive to Build Great Chillers. Partner with them as you Build Great Beer. Choose G&D Chillers on your next Expansion or Brewery start up and receive 1 free year of Remote control and Monitoring of your new G&D Chiller! ProBrew (https://www.probrew.com) “ProBrew is excited to now offer 2-4 week lead times on all in-stock ProFill Rotary Can Filler and Seamers. This special lead time is only while supplies last, so send us an email at contactus@probrew.com or call us at 262-278-4945. ProBrew, Brew YOUR Beer.” Old Orchard (https://www.oldorchard.com/brewer): Berry Blend, Blood Orange, Lemonade, and Tart Cherry are the latest additions to our lineup of flavored craft juice concentrate blends. To learn more and request your free samples, head over to oldorchard.com/brewer (https://www.oldorchard.com/brewer) Omega Yeast (https://omegayeast.com): Experience distinct transparency and juiciness with Omega Yeast's DayBreak-V. We've genetically eliminated haze in the popular British-V strain, allowing you to preserve the fruit-boosting prowess while achieving crystal clarity. Learn more at info@omegayeast.com. Five Star Chemical (https://fivestarchemicals.com) Our cleaning solutions are specifically formulated to meet the unique needs of breweries, ensuring that your equipment stays clean and free of harmful bacteria and contaminants. From cleaning fermenters to kegs, we have a solution for every step of the brewing process. RSS Maclin (https://RSSMACLIN.com) provides the training and resources breweries of all sizes need to ensure the exceptional quality of your product remains the same from beginning to end. For more information, visit RSSMACLIN.com or email Service@rssmaclin.com Indie Hops (https://indiehops.com) breeds new hop varieties to help brewers captivate beer lovers. Brewers worldwide trust Indie's unique varieties — Strata, Lórien, Luminosa, Meridian and Audacia — to modernize, brighten and diversify their beer lineup. Visit indiehops.com/podcast to discover what's new in hop flavors. Berkeley Yeast (https://berkeleyyeast.com). Superbloom strains make classic hops flavor; Fresh strains keep diacetyl low even with large hop additions; Tropics strains make a tropical bouquet reminiscent of the finest southern hemisphere hops. Mention this podcast for 20% off your first order. FOBAB (https:fobab.com). Sample more than 350 one-of-a-kind barrel-aged beer, cider, mead and perry from 13 style categories and cheer on your favorite breweries as they compete for top honors in the nationally recognized competition. It's all happening at the Festival of Wood & Barrel-Aged Beer in Chicago November 22nd and 23rd. Get your tickets now at fobab.com.

Danke an die WerbepartnerDiese Folge wird durch foryouehealth unterstützt. Selbsttests für zu Hause.foryou Selbsttests ermöglichen es Dir, Deine Biomarker aus Blut, Speichel, Atem oder Stuhl einfach und bequem zu messen. Einfach und bequem den Test zu Hause durchführen? Das geht mit den Tests von for you eHealth. Die Ergebnisse Deiner Darm- und Blutanalyse kannst du dann online abrufen. https://www.foryouehealth.de Mit dem Gutscheincode: Julia10 sparst du 10% auf die Produkte!Kapitel00:00:00 Introduction00:01:59 ForYou eHealth Selbsttest00:03:10 Begrüßung00:04:25 Gabi erzählt ihre Geschichte00:15:49 Neurobiologische Grundlagen der Sucht 00:16:54 Erzählung über Bill W., Gründer der Anonymen Alkoholiker, und seine Erfahrungen mit Nährstoffen.00:21:44 Rehakliniken als Geldmaschinen00:24:56 Vitaminmangel bei Alkoholabhängigen00:32:28 Aminosäuren und Neurotransmitter 00:47:00 Die Herausforderung des Suchtausstiegs00:54:10 Ratschläge für Angehörige von Süchtigen01:00:55 Ressourcen für BetroffeneWir sprechen überMein heutiger Gast ist Gaby Guzek, eine erfahrene Wissenschaftsjournalistin und Autorin, die selbst mehr als 20 Jahre lang alkoholabhängig war. Sie teilt mit uns nicht nur ihre persönliche Geschichte, sondern auch ihr umfangreiches Wissen über die biochemischen und neurobiologischen Grundlagen von Sucht. Gaby hat es geschafft, sich aus ihrer Abhängigkeit zu befreien – und zwar nicht durch den klassischen Weg, sondern durch die gezielte Nutzung von Mikronährstoffen und Nahrungsergänzungsmitteln. Heute unterstützt sie andere Menschen dabei, diesen Weg ebenfalls zu gehen.Warum solltest du unbedingt reinhören? Hier sind drei Gründe:Du wirst verstehen, dass Sucht kein Zeichen von Willensschwäche ist – es sind tiefgreifende biochemische Prozesse im Gehirn, die eine enorme Rolle spielen.Gaby zeigt dir, wie Mikronährstoffe und Aminosäuren eine entscheidende Rolle bei der Suchtbewältigung spielen können – und das oft ganz ohne klassische Therapieansätze.Für Angehörige von Betroffenen gibt es wertvolle Tipps, wie man richtig unterstützen kann, ohne dabei selbst Schaden zu nehmen oder in die Sucht des anderen hineingezogen zu werden.Alles über Gaby GuzekGaby Guzek, geboren 1967, arbeitete nach ihrem Studium unter anderem bei der »Frankfurter Allgemeinen Zeitung« und der Fachzeitschrift »Die Neue Ärztliche«. Seit mehr als 30 Jahren ist sie Fachjournalistin für Wissenschaft und Medizin. Jahrelang selbst von schwerer Alkoholsucht betroffen und mit den Therapiemöglichkeiten unzufrieden, begann sie, sich zusammen mit ihrem Mann, Dr. med. Bernd Guzek, intensiv mit dem Phänomen Sucht auseinanderzusetzen. 2020 veröffentlichte sie im Eigenverlag ihr Buch »Alkohol adé«. Heute steht Gaby Guzek als Coach Alkoholsüchtigen zur Seite und hilft ihnen dabei, ihre Sucht nachhaltig zu besiegen. Webseiten: http://gaby–guzek.comhttp://www.alkohol-ade.comFacebook Gruppehttps://www.facebook.com/AlkoholadeBücherDie Suchtlüge: Der Mythos von der fehlenden Willenskraft: Wie Sucht im Hirn entsteht und wie wir sie besiegen https://amzn.to/4h5rL6bAlkohol adé: Der direkte Weg zurück zur Gesundheit https://amzn.to/3Nmj4GR[Englische Ausgabe]Bye-bye, Booze: Understanding and Mastering Brain Chemistry in Alcohol Abuse and Addiction https://amzn.to/3NlkKQUAndere Bücher von Gaby GuzekPilze im Körper - Krank ohne Grund?: Pilzinfektionen erkennen und heilen, durch gesunde Ernährung vorbeugen https://amzn.to/3YldPh4Relevante ArtikelSchauss, Alexander G., and G. Facn Alexander. "Attenuation of heroin withdrawal syndrome by the administration of high-dose vitamin C." JOM 27.4 (2012): 189.https://www.researchgate.net/profile/Alexander-Schauss/publication/236834375_Attenuation_of_heroin_withdrawal_syndrome_by_the_administration_of_high-dose_vitamin_C/links/0deec537a559c707f0000000/Attenuation-of-heroin-withdrawal-syndrome-by-the-administration-of-high-dose-vitamin-C.pdfTalkhooncheh, Mahboobeh, et al. "The effect of vitamin C on morphine self-administration in rats." Advanced biomedical research 3.1 (2014): 178. https://journals.lww.com/adbm/fulltext/2014/03000/the_effect_of_vitamin_c_on_morphine.178.aspxSandoval, Cristian, et al. "Vitamin supplements as a nutritional strategy against chronic alcohol consumption? an updated review." Antioxidants 11.3 (2022): 564. https://www.mdpi.com/2076-3921/11/3/564?ref=dwrvchase.comZeige deinen SupportDir gefällt die Show und die Inhalte? Der beste Weg, uns zu unterstützen, kostet dich nur ein paar Sekunden. Hinterlasse eine Bewertung und/ oder einen Kommentar auf YouTube, iTunes oder Spotify.https://www.youtube.com/@JuliaTulipanKeto?sub_confirmation=1 Bitte beachten Sie auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf https://juliatulipan.com/haftungsausschluss/

Is avacincaptad pegol (Izervay, Astellas) effective in patients with major ellipsoid zone attenuation at baseline? Katherine Talcott, MD, stopped by our studio in Stockholm during ASRS with a top-line summary of her lecture at this year's meeting. And Sunir Garg, MD, joined us for a conversation about the GALE study, which assessed 36 months of continuous dosing of pegcetacoplan (Syfovre, Apellis Pharmaceuticals). What did microperimetry findings reveal about long-term dosing with C3 inhibition? Join us in this episode to find out. 

Positron Emission Tomography (PET) combined with Computed Tomography (CT) is a powerful imaging modality used in oncology for diagnosis, staging, and treatment monitoring. However, one limitation of PET/CT is the need for accurate attenuation correction (AC) to account for tissue density variations. Traditionally, low-dose CT scans are used for AC, but these contribute to patient radiation exposure. In a new study, researchers Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, and Stephanie A. Harmon from the National Cancer Institute proposed an artificial intelligence (AI) tool to generate attenuation-corrected PET (AC-PET) images directly from non-attenuation-corrected PET (NAC-PET) images, reducing the reliance on CT scans. Their research paper was published in Oncotarget's Volume 15 on May 7, 2024, entitled, “Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.” Full blog - https://www.oncotarget.org/2024/07/11/ai-for-improved-pet-ct-attenuation-correction-in-prostate-cancer-imaging/ Paper DOI - https://doi.org/10.18632/oncotarget.28583 Correspondence to - Stephanie A. Harmon - stephanie.harmon@nih.gov Video short - https://www.youtube.com/watch?v=0mZItCB8AtI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28583 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, deep learning, PSMA PET, attenuation correction About Oncotarget Oncotarget is an open-access, peer-reviewed journal that has published primarily oncology-focused research papers since 2010. These papers are available to readers (at no cost and free of subscription barriers) in a continuous publishing format at Oncotarget.com. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Some people say coax but Ron likes coaxial cable. Coaxial cable has been a key component in our networks dating back to the industry's early days. As such, it's easy to take coax for granted without really understanding just what it is. Here's your chance to learn more about coaxial cable, along with a high-level The post Coaxial Cable Impedance, Attenuation and Beyond appeared first on Volpe Firm.

Attenuation is the consumption of sugar by yeast.  More attenuation means less residual sugar which generally means a drier beer … or does it?  A lot of factors come into play in how much attenuation a beer will undergo and that is only somewhat related to how dry or sweet that beer will be perceived by the drinker.On this episode of the All About Beer Podcast, we talk with a Master Cicerone about how attenuation is related (or not) to dryness and we speak with a brewer about how he thinks about attenuation in recipe development.This Episode is Sponsored by:Estrella GaliciaEstrella Galicia is an independent, family-owned brewery  in northwest Spain, founded in 1906.Estrella Galicia Cerveza Especial is a world class lager, brewed using the finest Spanish malts, locally  cultivated Galician hops and the best brewing practices, in a state-of-the-art facility in La Coruña . Recognized around the world for quality and exceptional character. Estrella Galicia is “A beer like no other.”Hosts:  Don Tse and Em SauterGuests: Jen Blair and Brandon JonesSponsors: Estrella Galicia, All About BeerTags: Attenuation, Beer, Sugar, Brewing, RecipesThe following music was used for this media project:Music: Awesome Call by Kevin MacLeodFree download: https://filmmusic.io/song/3399-awesome-callLicense (CC BY 4.0): https://filmmusic.io/standard-licenseArtist website: https://incompetech.com ★ Support this podcast on Patreon ★

BUFFALO, NY- May 8, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 7, 2024, entitled, “Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.” The sequential PET/CT studies oncology patients can undergo during their treatment follow-up course is limited by radiation dosage. In this new study, researchers Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, and Stephanie A. Harmon from the National Institutes of Health's National Cancer Institute proposed an artificial intelligence (AI) tool to produce attenuation-corrected PET (AC-PET) images from non-attenuation-corrected PET (NAC-PET) images to reduce need for low-dose CT scans. “AI-generated PET images has clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality in prostate cancer patients.” Methods: A deep learning algorithm based on 2D Pix-2-Pix generative adversarial network (GAN) architecture was developed from paired AC-PET and NAC-PET images. 18F-DCFPyL PSMA (prostate-specific membrane antigen) PET-CT studies from 302 prostate cancer patients, split into training, validation, and testing cohorts (n = 183, 60, 59, respectively). Models were trained with two normalization strategies: Standard Uptake Value (SUV)-based and SUV-Nyul-based. Scan-level performance was evaluated by normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM), and peak signal-to-noise ratio (PSNR). Lesion-level analysis was performed in regions-of-interest prospectively from nuclear medicine physicians. SUV metrics were evaluated using intraclass correlation coefficient (ICC), repeatability coefficient (RC), and linear mixed-effects modeling. Results: Median NMSE, MAE, SSIM, and PSNR were 13.26%, 3.59%, 0.891, and 26.82, respectively, in the independent test cohort. ICC for SUVmax and SUVmean were 0.88 and 0.89, which indicated a high correlation between original and AI-generated quantitative imaging markers. Lesion location, density (Hounsfield units), and lesion uptake were all shown to impact relative error in generated SUV metrics (all p < 0.05). “The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.” DOI - https://doi.org/10.18632/oncotarget.28583 Correspondence to - Stephanie A. Harmon - stephanie.harmon@nih.gov Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28583 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this episode of Runnymede Radio, Kristopher Kinsinger sits down with Colton Fehr, Professor at the University of Saskatchewan's College of Law, to discuss his recently released book, Judging Sex Work: Bedford and the Attenuation of Rights.

Commentary by Dr. Valentin Fuster

Contributor Jordan Folks joins Cade in the lab to chat about the information discussed in last week's episode on attenuation. The Brü Lab is brought to you by Imperial Yeast who provide brewers with the most viable and fresh yeast on the market. Learn more about what Imperial Yeast has to offer at ImperialYeast.com today.

This week, Dr. Laura Burns from Omega Yeast returns to the lab to chat with Cade about all things attenuation. The Brü Lab is brought to you by Imperial Yeast who provide brewers with the most viable and fresh yeast on the market. Learn more about what Imperial Yeast has to offer at ImperialYeast.com today. | Read More | Know Your Yeast: Attenuation

reference: Sri Aurobindo and the Mother, The Hidden Forces of Life, Ch. 1 Life Through the Eyes of the Yogin, pp. 4-5 This episode is also available as a blog post at https://sriaurobindostudies.wordpress.com/2024/02/25/perceiving-the-universal-forces-at-work-through-attenuation-of-the-hold-of-the-ego-centric-viewpoint/   Santosh has been studying Sri Aurobindo's writings since 1971 and has a daily blog at http://sriaurobindostudies.wordpress.com and podcast at https://anchor.fm/santosh-krinsky  He is author of 20 books and is editor-in-chief at Lotus Press.  He is president of Institute for Wholistic Education, a non-profit focused on integrating spirituality into daily life.  More information about Sri Aurobindo can be found at http://www.aurobindo.net The US editions and links to e-book editions of Sri Aurobindo's writings can be found at http://www.lotuspress.com 

Rachael & Jen discuss attenuation.

100 Episodes?? What?? Join your Attenuation hosts as they celebrate this significant milestone with an epic beer tasting, some wild rants, and a fond look back over the first 100 episodes. Beer Tasting: Assembled Armor, Melvin Brewing, Eureka, MO. Style: BBA Barleywine/Stout Blend with Sesame Seeds, Sea Salt, Maple Syrup, and Cinnamon. Parabola, Firestone Walker, Paso Robles, CA. Style: BBA Stout

Foundations of Amateur Radio If you've been following my amateur radio journey, you'll have likely noticed that I've been straying from the fold. The words I use for power have been changing. I've reduced references to Watt and increased use of the term decibel. Initially this was incidental, recently it's been more of a deliberate decision and I'd like to explain how this came to be. It starts with representing really big and really small numbers. Let's start big. On 14 September, 2015 the first direct observation of gravitational waves was made when a pair of black holes with a combined estimated weight of 65 solar masses merged. The signal was named GW150914, combining "Gravitational Wave" and the observation date to immortalise the event. Following the collision, it was estimated that the radiated energy from the resulting gravitational waves was 50 times the combined power output of all the light from all the stars in the observable universe. As a number in Watts, that's 36 followed by 48 zeros. If you're curious, there's even a word for that, 36 Quindecillion Watts. Now let's look at small. The typical signal strength received from a GPS satellite, like say by your phone, is about 178 attowatts, or in Watts, 0.000 and so on, in all, 13 zeros between the decimal point and then 178. What if I told you that the energy associated with the collision of those two black holes could be expressed in comparison with a milliwatt. Remember, this collision emitted more energy than all the output of light from all the stars in the observable universe. The expression for all that power is 526 dBm. Similarly, the tiny received GPS signal can be expressed as -127.5 dBm. Just let that sink in. All the power in the observable universe through to the minuscule power received by the GPS in your phone, all expressed between 526 dBm and -127.5 dBm, and not a zero in sight. As I mentioned, the unit dBm relates to a milliwatt. As a starting point, let me tell you that 1 Watt is 1,000 milliwatts and is represented by 30 dBm. The decibel scale doesn't work quite the same as other number ranges you might be used to. Adding the value 3 doubles its size and adding the value 10 increases its size by a factor 10. For example, to double power from 1 Watt or 30 dBm, add 3 and get 33 dBm, which is the same as 2 Watts. If you want to increase 1 Watt by a factor 10, again, starting with 30 dBm, add 10 and get 40 dBm which is 10 Watts. Similarly, 50 dBm is 100 Watts and 60 dBm is 1,000 Watts. Going the other way, halving power, remove 3. So taking 3 from 60 dBm is 500 Watts or 57 dBm. Dividing power by a factor 10 works the same, take 10. So 47 dBm is 50 Watts and 37 dBm is 5 Watts. If you get lost, remember, dBm relates to a milliwatt. 1 Watt is 1,000 milliwatts and is represented by 30 dBm. Divide by a factor 1,000, remove 30 and end up with 0 dBm, which is the same as 1 milliwatt. I'll say that again, 0 dBm is the same as 1 milliwatt. It takes a little getting used to, but you can do some nifty things. For example, remove 10 to get a tenth of a milliwatt, or -10 dBm. This same process of adding and subtracting applies in other ways too. Attenuation, or making a signal weaker, and amplification, or making a signal stronger can use the same rules. For example, if you apply 3 dB of attenuation, you're making the signal 3 dB weaker, or halving it, so you subtract 3 dB from your power output. If your amplifier is rated at 6 dB gain, you're quadrupling the output and you add 6 dB to your power output. Similarly, if you talk about the gain of an antenna, you add it. If the gain is 20 dBi, you add it to the power output. You can use this for coax loss calculations as well. A 100m length of RG-58 at 28 MHz has a loss of 8 dB. You can directly subtract this from the power output of the transmitter and know precisely how much power is making it to the antenna. There's more. The radio amateur S9 signal strength on HF, something which we consider to be a strong signal, can be expressed as -73 dBm or a very small fraction of a milliwatt. An S8 signal is 6 dB weaker, or -79 dBm. A 20 over 9 report is -53 dBm. I will point out that this is at 50 Ohm. As a result, we now have a continuous scale for all the elements in the transmission chain between the transmitter and the receiver. While I'm here, I've already mentioned that negative dBm readings relate to fractions of a milliwatt, so values between 0 and 1. This highlights one limitation of this scale. We cannot represent 0 Watts. Mind you, that doesn't happen all that often. The thermal noise floor in space at 1 Hz bandwidth, that's at 4 kelvins, is -192.5 dBm, which practically means the minimum level of power we need to express. It's also a good value to remember because if you're doing funky calculations and you end up with a number less than -192.5 dBm, you can pretty much guarantee that you've probably made a boo-boo. 0 Watts using the dBm scale is represented by negative infinity, or essentially a division by zero error, really not defined, so there's that. I'm Onno VK6FLAB

Foundations of Amateur Radio Before we start I should give you fair warning. There are many moving parts in what I'm about to discuss and there's lots of numbers coming. Don't stress too much about the exact numbers. In essence, what I'm attempting is to explore how we can reduce the power output from a transmitter in such a way that it doesn't blow up a receiver whilst making sure that the signal is strong enough that we can actually measure it. With that in mind, recently I discussed the idea of adding a series of attenuators to a transmitter to reduce the power output by a known amount so you could connect it to a receiver and use that to measure output power at various frequencies. One hurdle to overcome is the need to handle enough power in order to stop magic smoke from escaping. None of my attenuators are capable of handling more than 1 or 2 Watts of power, so I cannot use any of them as the first in line. As it happens, a good friend of mine, Glynn VK6PAW, dropped off a device that allows you to divert most of the power into a dummy load and a small amount into an external connector. In effect creating an inline attenuator capable of handling 50 Watts. The label doesn't specify what the attenuation is, so I measured it using a NanoVNA. To make our job a little interesting, it isn't constant. Between 10 kHz and 1 GHz, the attenuation decreases from 70 dB to 10 dB. We want to measure at a base frequency on the 2m band and its second and third harmonic. The attenuation at those frequencies varies by 11 dB, which means we'll need to take that into account. So, let's subject our currently imaginary test set-up to some sanity checking. Our receiver is capable of reading sensible numbers between a signal strength of -127 dBm and -67 dBm and we'll need to adjust accordingly. If we transmit an actual 20 Watt carrier, that's 43 dBm. With 110 dB of attenuation, we end up at -67 dBm, which is right at the top end of what we think the receiver will handle. If we're using something like 5 Watts, or 37 dBm, we end up at -73 dBm, which is well above the minimum detectable signal. Our best harmonic measurement was around -30 dBm, which means that with 110 dB of attenuation, we end up at -140 dBm, which is 13 dB below what we think we can detect. So, at this point you might wonder if this is still worth our while, given that we're playing at the edges and to that I say: "Remind me again why you're here?" First we need to attenuate our 20 Watts down to something useful so we don't blow stuff up. Starting with 110 dB attenuation, we can measure our base carrier frequency and its harmonics and learn just how much actual power is coming out of the transmitter. Once we know that, we can adjust our attenuation to ensure that we end up at the maximum level for the receiver and see what we are left with. So, let's look at some actual numbers, mind you, we're just looking at calculated numbers, these aren't coming from an actual dongle, yet. Using Glynn's dummy load as the front-end, at 146.5 MHz, the attenuation is about 30 dB. If we look at a previously measured handheld and rounding the numbers, it produced 37 dBm. That's the maximum power coming into our set-up. With 30 dB of attenuation from Glynn's dummy load, that comes down to 7 dBm. We'll need an additional 74 dB of attenuation to bring that down to -67 dBm, in all we'll need 104 dB of attenuation. The third harmonic for that radio was measured at -26 dBm. So, with a 104 dB of attenuation that comes out at -130 dBm, which is below the minimum detectable signal supported by our receiver. However, remember that I told you that our dummy load had different attenuation for different frequencies? In our case, the attenuation at 439.5 MHz is only 19 dB, not 30, so in actual fact, we'd expect to see a reading of -119 dBm, which is above the minimum detectable signal level. I realise that's a lot of numbers to digest, and they're specific to this particular radio and dummy load, but they tell us that this is possible and that we're potentially going to be able to measure something meaningful using our receiver. I'll also point out that if you're going to do this, it would be a good idea to take notes and prepare what numbers you might expect to see because letting the magic smoke escape might not be one of your desired outcomes. Speaking of smoke, what happens if you consider changing the attenuation when you're measuring at another frequency, like say the second or third harmonic and you see a reading close to, or perhaps even below the detectable signal level as we've just discussed. You might be tempted to reduce the attenuation to increase the reading, but you need to remember that the transmitter is still actually transmitting at full power into your set-up, even if you're measuring elsewhere. This is why for some radios you'll see a measurement that states that the harmonics are below a certain value because the equipment used doesn't have enough range to provide an actual number. To simplify my life, using a NanoVNA, I created a spreadsheet with 101 data points for the attenuation levels of Glynn's dummy load between 10 kHz and 1 GHz. I charted it and with the help of the in-built trend-line function determined a formula that matched the data. I've also skipped over one aspect that needs mentioning and that's determining if the receiver you're using to do this is actually responding in the same way for every frequency. One way you might determine if that's the case is to look at what happens to the signal strength across multiple frequencies using a dummy load as the antenna. One tool, rtl_power might help in that regard. Is this going to give you the same quality readings as a professional piece of equipment? Well, do the test and tell me what you learn. I'm Onno VK6FLAB

An exploratory dive into the deepest depths of the psyche of a daring group of podcasters spirals into chaos when a malevolent video tutorial of smoking a joint threatens their mission and forces them into a high-stakes battle for their sanity. On Episode 580 of Trick or Treat Radio we discuss Meg 2: The Trench from director Ben Wheatley! We also discuss all the Meg's we know, we find out who is on the Mount Rushmore of the Five Star Stud Club, and we somehow talk a lot about Val Kilmer! So grab your futuristic underwater super suit, attenuate your attitude, and strap on for the world's most dangerous podcast!Stuff we talk about: Thanksgiving, Eli Roth, Patrick Dempsey, attenuate, CM Punk, TonyZero, stroking out on air, defrag your brain, MEGadeth, MEG Ryan, MEG Tilly, MEGatron, MEGaforce Records, Rolling Stones, Kids in the Hall, Val Kilmer, Top Secret!, Real Genius, Top Gun, The Doors, Oliver Stone, Peter Cushing, Mel Brooks, The Salton Sea, Danny Trejo, R. Lee Ermey, Jan-Michael Vincent, Vincent Schiavelli, Better Off Dead, Fast Times at Ridgemont High, Jibber Johnson, the Mount Rushmore of Five Star Stud Club, Don Knots, Paul Reubens, Larry Fine, Heart of Darkness, a collapsed whoopie cushion, VOID, going Septic, Ben Wheatley, Meg 2: The Trench, Jason Statham, John Turtletaub, Cool Runnings, 3 Ninjas, A Field in England, In the Earth, Free Fire, Stephen Scarlata, getting killed by a Megalodon, Snatch, Lock Stock and Two Smoking Barrels, Sky Captain, Crank, The Transporter Films, Freddy vs. Jason Statham, action sack, Jet Ski, trigger warnings, Day of the Animal, Jurassic Park, Perpetrator, shenanigans, A-Listers, the Brothers' Warner, A.I.-Lister, smelling burnt toast, Sounds of Buttstuff, MediaShame, What We Do in the Shadows, Summer School, Nation of Attenuation, These are the Megs I Know, Avoid the Void, and Jason Statham Takes Manhattan.Support us on Patreon: https://www.patreon.com/trickortreatradioJoin our Discord Community: discord.trickortreatradio.comSend Email/Voicemail: mailto:podcast@trickortreatradio.comVisit our website: http://trickortreatradio.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: http://www.facebook.com/groups/trickortreatradioTwitter: http://twitter.com/TrickTreatRadioFacebook: http://facebook.com/TrickOrTreatRadioYouTube: http://youtube.com/TrickOrTreatRadioInstagram: http://instagram.com/TrickorTreatRadioSupport the show

Exploring the science and data of microdosing, and briefing key drug interactions with the use of common used psychedelic therapies References: Cheung T. COMPASS Announces Positive Outcome of 25 mg COMP360 Psilocybin Therapy as Adjunct to SSRI Anti-depressant in Open-Label, Treatment-Resistant Depression Study. COMPASS Health. 13 Dec 2021 [press release]. Grinspoon P. The Popularity of Microdosing of Psychedelics: What Does the Science Say? Harvard Health. 19 Sept 2022. Gukasyan N, et al. Attenuation of Psilocybin Mushroom Effects During and After SSRI/SNRI Anti-depressant Use. Sage Journals. 2023 Jul; 37(7): 707-716 Malcolm B and Thomas K. Serotonin Toxicity of Serotonergic Psychedelics. Psychopharmacology. 2022;239: 1881-1891 Perez E, et al. The Psilocybin-Blunting Effects of SSRIs and Anti-depressants. Psychedelic Passage. 3 June 2022. Raison C, et al. Single Dose Psilocybin for Major Depressive Disorder. JAMA. 2023; 330(9): 843-853    

Foundations of Amateur Radio Recently I had the opportunity to use a piece of professional equipment to measure the so-called unwanted or spurious emissions that a transceiver might produce. In describing this I finished off with the idea that you could use a $20 RTL-SDR dongle to do these measurements in your own shack. I did point out that you should use enough attenuation to prevent the white smoke from escaping from your dongle, but it left a question, how much attenuation is enough? An RTL-SDR dongle is a USB powered device originally designed to act as a Digital TV and FM radio receiver. It's normally fitted with an antenna plugged into a socket on the side. I'll refer to it more generically as a receiver because much of what we're about to explore is applicable for other devices too. Using your transceiver, or transmitter, as a signal source isn't the same as tuning to a broadcast station, unless you move it some distance away, as-in meters or even kilometres away, depending on how much power you're using at the time. Ideally we want to connect the transmitter output directly to the receiver input so, at least theoretically, the RF coming from the transmitter stays within the measuring set-up between the two devices. Assuming you have a way to physically connect your transmitter to your receiver we need to work out what power levels are supported by your receiver. For an RTL-SDR dongle, this is tricky to discover. I came across several documents that stated that the maximum power level was 10 dBm or 0.01 Watt, but that seemed a little high, since an S9 signal is -73 dBm, so I kept digging and discovered a thoughtful report published in August 2013 by Walter, HB9AJG. It's called "Some Measurements on DVB-T Dongles with E4000 and R820T Tuners". There's plenty to learn from that report, but for our purposes today, we're interested in essentially two things, the weakest and strongest signals that the receiver can accommodate. We're obviously interested in the maximum signal, because out of the box our transmitter is likely to be much too strong for the receiver. We're going to need to reduce the power by a known amount using one or more connected RF attenuators. At the other end of the scale, the minimum signal is important because if we add too much attenuation, we might end up below the minimum detectable signal level of the receiver. Over the entire frequency range of the receivers tested in the report the minimum varies by about 14 dB, so let's pick the highest minimum from the report to get started. That's -127 dBm. What that means is that any signal that's stronger than -127 dBm is probably going to be detectable by the receiver and for some receivers on some frequencies, you might be able to go as low as -141 dBm. At the other end of the scale the report shows that the receiver range is about 60 dB, which means that the strongest signal that we can use is -67 dBm before various types of distortion start occurring. For comparison, that's four times the strength of an S9 signal. So, if we have a 10 Watt transmitter, or 40 dBm, we need to bring that signal down to a maximum of -67 dBm. In other words we need at least 107 dB of attenuation and if we have a safety margin of two, we'll need 110 dB of attenuation, remember, double power means adding 3 dB. So, find 110 dB of attenuation. As it happens, if I connect most of my attenuators together, I could achieve that level of attenuation, but there's one further issue that we'll need to handle and that's power. As you might recall, an attenuator has several attributes, the most obvious one is how much attenuation it brings to the party. It's specified in dB. My collection of attenuators range from 1 dB to 30 dB. Another attribute is the connector it comes with, I have both N-type and SMA connectors in my collection, so I'll need some adaptors to connect them together. One less obvious and at the cheap end of the scale, often undocumented, aspect of an attenuator is its ability to handle power. Essentially we're turning an RF signal into heat, so an attenuator needs to be able to dissipate that heat to handle what your transmitter is throwing at it. I said that from a safety perspective I'd like to be able to handle 20 Watts of power. Fortunately we don't need all our attenuators to be able to handle 20 Watts, just the first one directly connected to the transmitter. If we were to use a 20 Watt, 30 dB attenuator, the signal through the attenuator is reduced to 0.02 Watts and the next attenuator in line only needs to be able to handle that power level and so-on. To get started, find about 110 dB of attenuation, make sure it can handle 20 Watts and you can start playing. Before you start keying up your transmitter, how might you handle a range of different transmitters and power levels and can you remove an attenuator when you test on a different frequency? On that last point, let me say "No", you cannot remove the attenuator when you're measuring a different frequency. I'm Onno VK6FLAB

Sophie Spital is Triggernometry's video editor and the first employee to have joined the Trig team all the way back in 2020. When she's not behind a computer screen making us look good, she speaks and writes about issues including gender dysphoria, autism and ideology - topics with which she has had more than her fair share of first hand experience! Sophie's Twitter: https://twitter.com/SophieSpital Sophie's Substack: https://sophiespital.substack.com/ SPONSORED BY: BetterHelp. Give online therapy a try at https://www.betterhelp.com/trigger/ - get 10% off your first month, and get on your way to being your best self. SPONSORED BY: Manscaped. Get 20% off and free shipping when you use the code TRIGGER20 at https://www.manscaped.com/ Sex and Autism study: https://www.researchgate.net/publication/263971492_Attenuation_of_Typical_Sex_Differences_in_800_Adults_with_Autism_vs_3900_Controls Join our exclusive TRIGGERnometry community on Locals! https://triggernometry.locals.com/ OR Support TRIGGERnometry Here: Bitcoin: bc1qm6vvhduc6s3rvy8u76sllmrfpynfv94qw8p8d5 Music by: Music by: Xentric | info@xentricapc.com | https://www.xentricapc.com/ YouTube:  @xentricapc   Buy Merch Here: https://www.triggerpod.co.uk/shop/ Advertise on TRIGGERnometry: marketing@triggerpod.co.uk Join the Mailing List: https://www.triggerpod.co.uk/sign-up/ Find TRIGGERnometry on Social Media:  https://twitter.com/triggerpod https://www.facebook.com/triggerpod/ https://www.instagram.com/triggerpod/ About TRIGGERnometry:  Stand-up comedians Konstantin Kisin (@konstantinkisin) and Francis Foster (@francisjfoster) make sense of politics, economics, free speech, AI, drug policy and WW3 with the help of presidential advisors, renowned economists, award-winning journalists, controversial writers, leading scientists and notorious comedians. 00:00 Intro  01:07 Sophie Spital's Background 04:51 The Liberal Feminist Mindset 09:29 How Autism Impacts Worldview  11:48 Gender Identification  17:27 Experiencing Gender Dysphoria 21:42 Social Media's Influence on Gender Ideology 25:56 Sponsor Message: BetterHelp 27:47 The Connection Between Autism & Gender Dysphoria 40:38 Why Aren't We Recognising Autism? 46:04 'Identifying With' Vs 'Identifying As' 34:13 Sponsor Message: Manscaped 55:37 The Implications of the New Trans Worldview 58:04 Do These New Trans Policies Say Something Deeper About Society? 59:21 The Invention of the Concept of Gender 1:03:23 What Other Positive Changes Do we Need to Make? 1:09:15 The Demonisation of Masculinity 1:12:11 Coming to Peace with Who You Are 1:15:32 What's the One Thing We're Not Talking About?

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.27.546676v1?rss=1 Authors: Mazor, Y., Engelmayer, N., Nashashibi, H., Rottenfusser, L., Lev, S., Binshtok, A. M. Abstract: Background and Aims: Abdominal pain in patients with inflammatory bowel disease (IBD) is common and debilitating. In our study, we aim to utilize transient receptor potential vanilloid 1 (TRPV1) channels, large-pore cation channels expressed on nociceptors, as a drug delivery system to selectively inhibit visceral nociceptors and thus visceral pain in a rodent model of IBD. Methods: We induced colitis in rats using intrarectal dinitrobenzene sulfonic acid. Visceral hypersensitivity, spontaneous pain, and responsiveness of the hind paws to noxious heat stimuli were examined before and after the intrarectal application of sodium channel blocker QX-314 alone or together with TRPV1 channel activators or blockers. Results: Intrarectal co-application of QX-314 with TRPV1 channel activator capsaicin significantly inhibited colitis-induced gut hypersensitivity. Furthermore, in the model of colitis, but not in naive rats, QX-314 alone was sufficient to reverse gut hypersensitivity. The blockade of TRPV1 channels prevented this effect of QX-314. Finally, applying QX-314 alone to the inflamed gut inhibited colitis-induced ongoing pain. Conclusions: Selective silencing of nociceptors by QX-314 entering via exogenously or endogenously activated TRPV1 channels diminish IBD-induced gut hypersensitivity. These results yet again confirm the central role of TRPV1-expressing nociceptive neurons in IBD pain. The lack of QX-314 effect on naive rats suggests its selective analgesic effect in IBD pain. Moreover, our results demonstrating the effect of QX-314 alone imply the role of a tonically active TRPV1 channel in the pathophysiology of IBD pain. This approach provides proof-of-concept for using charged activity blockers for selective and effective blockade of visceral pain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Bipolar Disorder has been listed as one of the leading disorders of the Global Burden of Diseases... Yet the amount of research and funding put towards it is abysmal. Laine and I share that during our clinical education, we were taught almost nothing about the experience of mania, diagnosing, or treating the disorders like Bipolar. This episode share's what we know so far (from the MANY articles Laine went through to try to make sense of it) and what's happening in the brain -- referencing studies from Harrison, Gettes, Tunbridge, Clark, Sahakian, and more. It also touches on what needs to be done to not only better support those who have experienced manic episodes or have been diagnosed, but what is required for the field of mental health to improve. The takeaways of this episode are some of our favorites -- you can hear it in Laine's voice at the end. Enjoy -- and as always, if you have any questions feel free to email us at info@brainblownpodcast.com. REFERENCES Dionisio et al. - "Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania" Dzirasa et al. - "Impaired Limbic Gamma Oscillatory Synchrony during Anxiety-Related Behavior in a Genetic Mouse Model of Bipolar Mania" Ferrari et al. - "Depression and Mania Induce Pro-inflammatory Activation of Macrophages Following Application of Serum from Individuals with Bipolar Disorder" Schmidta et al. - "Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls" de Soussa et al. - "Lithium increases plasma brain-derived neurotrophic factor in acute bipolarmania: A preliminary 4-week study" Paul J. Harrison, John R. Geddes, and Elizabeth M. Tunbridge1 - "The Emerging Neurobiology of Bipolar Disorder" Luke Clark, Barbara J. Sahakian - "Cognitive neuroscience and brain imaging in bipolar disorder" G.S. Kirshenbaum, C. R. Burgess, N. De'ry, M. Fahnestock, J. H. Peever and J C Roder - "Attenuation of mania-like behavior in na+,k+-atpase a3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise" Emre Bora - "Neurocognitive features in clinical subgroups of bipolar disorder: A meta-analysis" Ryan W. Logan, Ph.D. and Colleen A. McClung, Ph.D. - "Animal Models of Bipolar Mania: The Past, Present and Future"

A new research paper was published in Oncotarget's Volume 14 on March 21, 2023, entitled, “Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior.” Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. In this recent cancer-wide GPC expression study, researchers Fang Cheng, Victor Chérouvrier Hansson, Grigorios Georgolopoulos, and Katrin Mani from Lund University and Genevia Technologies used clinical cancer patient data in The Cancer Genome Atlas to reveal net upregulation of GPC1 and GPC2 in primary solid tumors. On the other hand, GPC3, GPC5 and GPC6 displayed lowered expression patterns compared to normal tissues. “[...] we identify and propose a mechanism where GPC1 interacts with extracellular matrix mediating signal transduction by mitogenic molecules involving TGF-β and p38 MAPK.” Focusing on GPC1, the researchers conducted survival analyses of the clinical cancer patient data that revealed a statistically significant correlation between high expression of GPC1 and poor prognosis in 10 particular cancer types: bladder urothelial carcinoma, brain lower grade glioma, liver hepatocellular carcinoma, colon adenocarcinoma, kidney renal clear cell carcinoma, lung adenocarcinoma, mesothelioma, ovarian serous cystadenocarcinoma, uterine corpus endometrial carcinoma, and uveal melanoma. In vitro studies targeting GPC1 expression by CRISPR/Cas9 or siRNA or treatment with an anti-GPC1 antibody resulted in attenuation of proliferation of cancer cells from bladder carcinoma, glioma and hepatocellular carcinoma patients (T24, U87 and HepG2 cells). Further, GPC1 overexpression exhibited a significant and negative correlation between GPC1 expression and proliferation of T24 cells. Their attempt to reveal the mechanism through which downregulation of GPC1 leads to attenuation of tumor growth using systematic Ingenuity Pathway Analysis indicated that suppression of GPC1 results in ECM-mediated inhibition of specific pro-cancer signaling pathways involving TGF-β and p38 MAPK. The team also identified differential expression and pleiotropic effects of GPCs in specific cancer types. This emphasizes their potential as novel diagnostic tools and prognostic factors, and open doors for future GPC targeted therapy. “It is plausible to measure circulating GPCs in serum, plasma or urine using a variety of methods including ELISA, urine cell sediments or exosome isolation [13, 24]. Further, detection and quantification of GPC1 by histopathological and immunohistochemical methods in tumor biopsies could be a new way to predict the biological outcome. The results of this investigation would also emphasize the potential of GPCs as novel tumor antigens, and open for GPC targeted immunotherapy. GPC targeted immunotherapy would be of high value, especially as we move into an era of precision and personalized cancer therapy.” DOI: https://doi.org/10.18632/oncotarget.28388 Correspondence to: Katrin Mani - katrin.mani@med.lu.se Keywords: Glypican-1, TCGA, bladder carcinoma, hepatocellular carcinoma, glioma About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget MEDIA@IMPACTJOURNALS.COM

 Attenuation correction using intrinsic detector gammasMohammadreza Teimoorisichani from SiemensWe talk a about how we can use the intrinsic radioactivity from the PET LSO detectors to assist with attenuation correction. A very cool idea.Nuccast.com ,UniversityofMelbourne ,SNMMI ,NIF  ,PET ,NuclearMedicine ,Podcast ,MolecularMedicine, DeepLearning, MBCIU, Siemens, Physics, Radiation, AttenuationPlease let me know what you think about the video versions of the podcast.I am also looking for new material so please get in touch with me if you can contributewith an interview.Direct link to iTuneshttps://itunes.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicinie-podcast/id1444565219?mt=2Older podcastshttps://podcasts.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicine-podcast/id94286547You can get the podcast page at both http://nuccast.com and http://www.nuccast.com with the feed to put into iTunes or juice or your favourite podcast software can be found at http://molcast.com/.The cardiac subset of the podcast can be found at http://cardiac.nuccast.com/Please pass on information about this podcast to your colleagues and to your CPD provider.Link to Video Link to Video fileLink to Audio file Link to Audio fileOr you can subscribe by entering your email address below and you will be informed of new episodesEnter your email address:Delivered by FeedBurnerMost importantly of all please help this podcast by contributing your opinions, Sound files, and emailsnucmedpodcast@gmail.comAll contributions welcome, especially as sound files to nucmedpodcast@gmail.com.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-GB; mso-fareast-language:EN-US;}div.WordSection1 {page:WordSection1;}

Attenuation correction using intrinsic detector gammasMohammadreza Teimoorisichani from SiemensWe talk a about how we can use the intrinsic radioactivity from the PET LSO detectors to assist with attenuation correction. A very cool idea.Nuccast.com ,UniversityofMelbourne ,SNMMI ,NIF  ,PET ,NuclearMedicine ,Podcast ,MolecularMedicine, DeepLearning, MBCIU, Siemens, Physics, Radiation, AttenuationPlease let me know what you think about the video versions of the podcast.I am also looking for new material so please get in touch with me if you can contributewith an interview.Direct link to iTuneshttps://itunes.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicinie-podcast/id1444565219?mt=2Older podcastshttps://podcasts.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicine-podcast/id94286547You can get the podcast page at both http://nuccast.com and http://www.nuccast.com with the feed to put into iTunes or juice or your favourite podcast software can be found at http://molcast.com/.The cardiac subset of the podcast can be found at http://cardiac.nuccast.com/Please pass on information about this podcast to your colleagues and to your CPD provider.Link to Video Link to Video fileLink to Audio file Link to Audio fileOr you can subscribe by entering your email address below and you will be informed of new episodesEnter your email address:Delivered by FeedBurnerMost importantly of all please help this podcast by contributing your opinions, Sound files, and emailsnucmedpodcast@gmail.comAll contributions welcome, especially as sound files to nucmedpodcast@gmail.com.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-GB; mso-fareast-language:EN-US;}div.WordSection1 {page:WordSection1;}

Attenuation correction using intrinsic detector gammasMohammadreza Teimoorisichani from SiemensWe talk a about how we can use the intrinsic radioactivity from the PET LSO detectors to assist with attenuation correction. A very cool idea.Nuccast.com ,UniversityofMelbourne ,SNMMI ,NIF  ,PET ,NuclearMedicine ,Podcast ,MolecularMedicine, DeepLearning, MBCIU, Siemens, Physics, Radiation, AttenuationPlease let me know what you think about the video versions of the podcast.I am also looking for new material so please get in touch with me if you can contributewith an interview.Direct link to iTuneshttps://itunes.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicinie-podcast/id1444565219?mt=2Older podcastshttps://podcasts.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicine-podcast/id94286547You can get the podcast page at both http://nuccast.com and http://www.nuccast.com with the feed to put into iTunes or juice or your favourite podcast software can be found at http://molcast.com/.The cardiac subset of the podcast can be found at http://cardiac.nuccast.com/Please pass on information about this podcast to your colleagues and to your CPD provider.Link to Video Link to Video fileLink to Audio file Link to Audio fileOr you can subscribe by entering your email address below and you will be informed of new episodesEnter your email address:Delivered by FeedBurnerMost importantly of all please help this podcast by contributing your opinions, Sound files, and emailsnucmedpodcast@gmail.comAll contributions welcome, especially as sound files to nucmedpodcast@gmail.com.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-GB; mso-fareast-language:EN-US;}div.WordSection1 {page:WordSection1;}

 Attenuation correction using intrinsic detector gammasMohammadreza Teimoorisichani from SiemensWe talk a about how we can use the intrinsic radioactivity from the PET LSO detectors to assist with attenuation correction. A very cool idea.Nuccast.com ,UniversityofMelbourne ,SNMMI ,NIF  ,PET ,NuclearMedicine ,Podcast ,MolecularMedicine, DeepLearning, MBCIU, Siemens, Physics, Radiation, AttenuationPlease let me know what you think about the video versions of the podcast.I am also looking for new material so please get in touch with me if you can contributewith an interview.Direct link to iTuneshttps://itunes.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicinie-podcast/id1444565219?mt=2Older podcastshttps://podcasts.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicine-podcast/id94286547You can get the podcast page at both http://nuccast.com and http://www.nuccast.com with the feed to put into iTunes or juice or your favourite podcast software can be found at http://molcast.com/.The cardiac subset of the podcast can be found at http://cardiac.nuccast.com/Please pass on information about this podcast to your colleagues and to your CPD provider.Link to Video Link to Video fileLink to Audio file Link to Audio fileOr you can subscribe by entering your email address below and you will be informed of new episodesEnter your email address:Delivered by FeedBurnerMost importantly of all please help this podcast by contributing your opinions, Sound files, and emailsnucmedpodcast@gmail.comAll contributions welcome, especially as sound files to nucmedpodcast@gmail.com.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-GB; mso-fareast-language:EN-US;}div.WordSection1 {page:WordSection1;}

 Attenuation correction using intrinsic detector gammasMohammadreza Teimoorisichani from SiemensWe talk a about how we can use the intrinsic radioactivity from the PET LSO detectors to assist with attenuation correction. A very cool idea.Nuccast.com ,UniversityofMelbourne ,SNMMI ,NIF  ,PET ,NuclearMedicine ,Podcast ,MolecularMedicine, DeepLearning, MBCIU, Siemens, Physics, Radiation, AttenuationPlease let me know what you think about the video versions of the podcast.I am also looking for new material so please get in touch with me if you can contributewith an interview.Direct link to iTuneshttps://itunes.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicinie-podcast/id1444565219?mt=2Older podcastshttps://podcasts.apple.com/au/podcast/the-nuclear-medicine-and-molecular-medicine-podcast/id94286547You can get the podcast page at both http://nuccast.com and http://www.nuccast.com with the feed to put into iTunes or juice or your favourite podcast software can be found at http://molcast.com/.The cardiac subset of the podcast can be found at http://cardiac.nuccast.com/Please pass on information about this podcast to your colleagues and to your CPD provider.Link to Video Link to Video fileLink to Audio file Link to Audio fileOr you can subscribe by entering your email address below and you will be informed of new episodesEnter your email address:Delivered by FeedBurnerMost importantly of all please help this podcast by contributing your opinions, Sound files, and emailsnucmedpodcast@gmail.comAll contributions welcome, especially as sound files to nucmedpodcast@gmail.com.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:EN-GB; mso-fareast-language:EN-US;}div.WordSection1 {page:WordSection1;}

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.02.530499v1?rss=1 Authors: Barbour, A. J., Gourmaud, S., Li, X., Stewart, D. A., Irwin, D. J., Talos, D. M., Jensen, F. E. Abstract: Increasing evidence indicates a bidirectional relationship between epilepsy and Alzheimer's disease (AD) with 22% of AD patients additionally suffering from seizures, which may be a targetable component of disease progression. Since epileptogenesis is associated with changes in excitatory: inhibitory (E:I) balance, we examined postmortem AD brain tissue from patients with and without seizure history and five times familial AD (5XFAD) mice for changes in several markers of E:I balance, including the inhibitory GABAA receptor, the chloride cotransporters, sodium potassium chloride cotransporter 1 (NKCC1) and potassium chloride cotransporter 2 (KCC2), and the excitatory NMDA and AMPA type glutamate receptors. We hypothesized that seizure history in AD patients would be associated with greater E:I imbalances, and that such changes would also be observed in the 5XFAD mice following pentylenetetrazol (PTZ) kindling. We found that seizures in AD patients were associated with alterations in NKCC1 and KCC2 expression, indicative of depolarizing GABA, and exacerbated cognitive deficits. Seizures also significantly contributed to E:I imbalance in the 5XFAD mouse model, as similar changes in NKCC1 and KCC2 expression were found in PTZ treated 5XFAD mice, along with altered AMPA receptor protein expression indicative of calcium permeable-AMPA receptors. In addition, we found that chronic treatment with the mTOR inhibitor rapamycin at doses we have previously shown to attenuate seizure-induced {beta}-amyloid pathology and cognitive deficits in 5XFAD mice, can mitigate the dysregulation of markers of E:I balance in this model. These data suggest that mTOR activation plays a role in modifying the E:I imbalance and network hyperexcitability in AD and that the FDA-approved mTOR inhibitors such as rapamycin may have potential for therapy in AD patients with a seizure history. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527923v1?rss=1 Authors: Paek, A. Y., Prashad, S. Abstract: Brain Machine Interfaces (BMIs) are systems that can help restore motor function to individuals with paralysis. These systems utilize machine learning algorithms to detect how the user wants to control an assistive device from their brain activity. These algorithms require a training dataset to infer patterns between a user's brain waves and the control signal for the assistive device. These training datasets consist of brain activity recordings while participants perform a very repetitive motor task. We hypothesize that these training datasets can be compromised due to the high number of trials. We anticipate that the movement-related brain waves of interest attenuate over time due to neural efficiency, where the brain becomes more efficient with practice in a motor task. To explore this hypothesis, we used an open-access EEG dataset where participants performed a simple reach-and-lift task. From each trial, time windows associated with resting and movement periods were segmented. Alpha and beta-band spectral power was estimated for each of these epochs and event-related desynchronization (ERD) was estimated as the suppression in spectral power from rest to movement. These ERDs were compared between early and late trials in the dataset. We also used linear discriminant analysis to assess a machine learning algorithm's accuracy in classifying whether the time windows belonged to rest or movement based on the spectral power band. We found that earlier trials had stronger ERDs and larger classification accuracies, suggesting that the repetition in the motor task causes attenuation of movement-related brain wave patterns and reduces efficacy of the dataset. These results call for a reevaluation of BMI performance in datasets that have numerous trials and an exploration of strategies that can compensate for longitudinal changes in movement-related brain activity used for BMIs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

After a 4-week hiatus, your hosts are back, starting the new year and new season with a wrap-up of 2022. Both hosts share what they learned and, more importantly, what beers they tasted and loved over the last year. Also, brewery visits, brewery mergers, and a very sad recipe change. Beer Tastings: Jason - Wizard Burial Ground, Brewery Vivant, Grands Rapids, MI. Style: BBA Quadrupel Stephen - Jaguar Shark Deep Search Series: Toppling Goliath, Pinthouse Brewing, Austin, TX. Style: BBA Imperial Stout --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

A Sample of Dust Attenuation Laws for DES Supernova Host Galaxies by J. Duarte et al. on Tuesday 29 November Type Ia supernovae (SNe Ia) are useful distance indicators in cosmology, provided their luminosity is standardized by applying empirical corrections based on light-curve properties. One factor behind these corrections is dust extinction, accounted for in the color-luminosity relation of the standardization. This relation is usually assumed to be universal, which could potentially introduce systematics into the standardization. The ``mass-step'' observed for SNe Ia Hubble residuals has been suggested as one such systematic. We seek to obtain a completer view of dust attenuation properties for a sample of 162 SN Ia host galaxies and to probe their link to the ``mass-step''. We infer attenuation laws towards hosts from both global and local (4 kpc) Dark Energy Survey photometry and Composite Stellar Population model fits. We recover a optical depth/attenuation slope relation, best explained by differing star/dust geometry for different galaxy orientations, which is significantly different from the optical depth/extinction slope relation observed directly for SNe. We obtain a large variation of attenuation slopes and confirm these change with host properties, like stellar mass and age, meaning a universal SN Ia correction should ideally not be assumed. Analyzing the cosmological standardization, we find evidence for a ``mass-step'' and a two dimensional ``dust-step'', both more pronounced for red SNe. Although comparable, the two steps are found no to be completely analogous. We conclude that host galaxy dust data cannot fully account for the ``mass-step'', using either an alternative SN standardization with extinction proxied by host attenuation or a ``dust-step'' approach. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14291v1

A Sample of Dust Attenuation Laws for DES Supernova Host Galaxies by J. Duarte et al. on Monday 28 November Type Ia supernovae (SNe Ia) are useful distance indicators in cosmology, provided their luminosity is standardized by applying empirical corrections based on light-curve properties. One factor behind these corrections is dust extinction, accounted for in the color-luminosity relation of the standardization. This relation is usually assumed to be universal, which could potentially introduce systematics into the standardization. The ``mass-step'' observed for SNe Ia Hubble residuals has been suggested as one such systematic. We seek to obtain a completer view of dust attenuation properties for a sample of 162 SN Ia host galaxies and to probe their link to the ``mass-step''. We infer attenuation laws towards hosts from both global and local (4 kpc) Dark Energy Survey photometry and Composite Stellar Population model fits. We recover a optical depth/attenuation slope relation, best explained by differing star/dust geometry for different galaxy orientations, which is significantly different from the optical depth/extinction slope relation observed directly for SNe. We obtain a large variation of attenuation slopes and confirm these change with host properties, like stellar mass and age, meaning a universal SN Ia correction should ideally not be assumed. Analyzing the cosmological standardization, we find evidence for a ``mass-step'' and a two dimensional ``dust-step'', both more pronounced for red SNe. Although comparable, the two steps are found no to be completely analogous. We conclude that host galaxy dust data cannot fully account for the ``mass-step'', using either an alternative SN standardization with extinction proxied by host attenuation or a ``dust-step'' approach. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14291v1

A Sample of Dust Attenuation Laws for DES Supernova Host Galaxies by J. Duarte et al. on Monday 28 November Type Ia supernovae (SNe Ia) are useful distance indicators in cosmology, provided their luminosity is standardized by applying empirical corrections based on light-curve properties. One factor behind these corrections is dust extinction, accounted for in the color-luminosity relation of the standardization. This relation is usually assumed to be universal, which could potentially introduce systematics into the standardization. The ``mass-step'' observed for SNe Ia Hubble residuals has been suggested as one such systematic. We seek to obtain a completer view of dust attenuation properties for a sample of 162 SN Ia host galaxies and to probe their link to the ``mass-step''. We infer attenuation laws towards hosts from both global and local (4 kpc) Dark Energy Survey photometry and Composite Stellar Population model fits. We recover a optical depth/attenuation slope relation, best explained by differing star/dust geometry for different galaxy orientations, which is significantly different from the optical depth/extinction slope relation observed directly for SNe. We obtain a large variation of attenuation slopes and confirm these change with host properties, like stellar mass and age, meaning a universal SN Ia correction should ideally not be assumed. Analyzing the cosmological standardization, we find evidence for a ``mass-step'' and a two dimensional ``dust-step'', both more pronounced for red SNe. Although comparable, the two steps are found no to be completely analogous. We conclude that host galaxy dust data cannot fully account for the ``mass-step'', using either an alternative SN standardization with extinction proxied by host attenuation or a ``dust-step'' approach. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14291v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.25.517892v1?rss=1 Authors: Kilteni, K., Houborg, C., Ehrsson, H. H. Abstract: Intrinsic delays in sensory feedback can be detrimental for motor control. As a compensation strategy, the brain predicts the sensory consequences of movement via a forward model on the basis of a copy of the motor command. Using these predictions, the brain attenuates the somatosensory reafference to facilitate the processing of exafferent information. Theoretically, this predictive attenuation gets disrupted by (even minimal) temporal errors between the predicted and the actual reafference, but direct evidence for such disruption is lacking since previous neuroimaging studies contrasted conditions of nondelayed reafferent input with exafferent one. Here, we combined psychophysics with functional magnetic resonance imaging to test whether subtle perturbations in the timing of somatosensory reafference disrupt its predictive processing. Twenty-eight participants generated touches on their left index finger by tapping a sensor with their right index finger. The touches on the left index finger were delivered at the time of the two fingers contact or with a 100 ms delay. We found that such brief temporal perturbations disrupted the attenuation of the somatosensory reafference both at the perceptual and neural level, leading to greater somatosensory and cerebellar responses and weaker somatosensory connectivity with the cerebellum proportionally to perceptual changes. Moreover, we observed increased connectivity of the supplementary motor area with the cerebellum during the perturbations. We interpret these effects as the failure of the forward model to predictively attenuate the delayed somatosensory reafference and the return of the prediction error to the motor centers, respectively. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The quality of mine water discharge has improved significantly over the last decade, and research suggests that government could consider a transition away from current, active acid mine drainage (AMD) treatments, to a more passive approach. Council for Geoscience (CGS) environmental geosciences senior scientist Dr Godfrey Madzivire, speaking at the 2022 CGS Summit, explained that AMD is currently treated using High-Density Sludge (HDS) treatment plants, which are costly and energy intensive. Moreover, as the HDS plants are powered by coal-fired power stations, the current solution is, in essence, “shifting the burden from the hydrosphere to the atmosphere”. In his presentation on ‘Natural processes in pollution attenuation: case study for a long-term solution to mine water management in the Witwatersrand goldfields', he explained that AMD is characterised by two types of acidity – vestigial acidity and juvenile acidity. In an earlier presentation, CGS water and the environment specialist scientist Dr Henk Coetzee explained that vestigial acidity is generated by the initial flushing of solid oxidation products, that is, the soluble salts formed when pyrite is oxidised, which are “flushed out” as the water level rises. Vestigial acidity has high salinity and is of very poor quality, but is short-lived. Juvenile acidity, meanwhile, is the newly generated acidity, which is less contaminated and its rate of generation slows substantially after initial flooding. Madzivire explained that vestigial acidity is depleted after 20 to 40 years, while juvenile acidity continues “in perpetuity”. He stated that current AMD treatment methods resulted from the Inter-Ministerial Recommendations Committee Report, published in 2010, which used a model developed by the Department of Water and Sanitation, which “did not consider natural attenuation”. He commented that, when mining activity ceases and the water is allowed to rise – as the pumps that maintain the water level are shut off – the highly toxic “first flush” occurs, with the quality of the mine water discharge improving thereafter. He noted that the inter-Ministerial recommendations were based on results compiled between 2002 and 2010, during the first flush stage for a significant number of mines, and as a result the water had very high sulphate concentrations and pH values as low as 2. However, as early as 2010, the mine water pH had improved to between 5.5. and 6, and over the last decade, sulphate concentration in the mine discharge has declined by 30%, while iron concentration has declined by 50%. Given these improvements, Madzivire suggested that a shift toward more sustainable water management solutions in the Wits basin should be pursued, outlining scenarios for long-term mine water management such as completely flooding the mine void; using water to dilute vestigial pollution or passive treatment also known as natural attenuation. He cited preliminary results from the East Rand AMD treatment facilities, noting that when water is discharged from the mines, it has a sulphate concentration of 1 500 mg/l. “Just after, when it mixes with the water in the Blesbok, the concentration declines to 300 mg/l. We still need to explore if this is because of the dilution, or natural attenuation. As the water flows towards the Vaal River system, additional natural processes occur, and the sulphate concentration drops further to 200 mg/l, which is better than the recommended rate for potable water.” He commented that it is uncertain if entities can continually use HDS to treat the water in the mine void, and while the ideal solution is dilution, the dilution source can also be highly polluted, and the likelihood of experiencing “ideal” conditions is slim. As such, passive methods, in conjunction with controlled flooding, are the most feasible for longer-term mine water management. CONTROLLED FLOODING Coetzee, in his presentation on ‘Flooding of the Witwatersrand gold mines: the influence of to...

Searching Lorentz invariance violation from cosmic photon attenuation by Hao Li et al. on Wednesday 12 October Lorentz invariance violation~(LIV) can change the threshold behavior predicted by special relativity and cause threshold anomalies which affect the propagation of cosmic photons. In this work, we focus on the threshold anomaly effect on cosmic photon attenuations by extragalactic background light~(EBL) and discuss how to identify LIV from observations of very high energy~(VHE) photons propagated from long distance in the universe. We point out that the Large High Altitude Air Shower Observatory~(LHAASO), one of the most sensitive gamma-ray detector arrays currently operating at TeV and PeV energies, is an ideal facility for performing such LIV searching. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2210.05563v1

Searching Lorentz invariance violation from cosmic photon attenuation by Hao Li et al. on Wednesday 12 October Lorentz invariance violation~(LIV) can change the threshold behavior predicted by special relativity and cause threshold anomalies which affect the propagation of cosmic photons. In this work, we focus on the threshold anomaly effect on cosmic photon attenuations by extragalactic background light~(EBL) and discuss how to identify LIV from observations of very high energy~(VHE) photons propagated from long distance in the universe. We point out that the Large High Altitude Air Shower Observatory~(LHAASO), one of the most sensitive gamma-ray detector arrays currently operating at TeV and PeV energies, is an ideal facility for performing such LIV searching. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2210.05563v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.25.509400v1?rss=1 Authors: Harding-Jackson, L., Beatty, J. A., Cox, C. L. Abstract: The thalamic reticular nucleus (TRN) sits at the interface of the thalamus and neocortex and provides the majority of inhibition to thalamic relay nuclei. Functionally, the activity of TRN neurons can impact sensory processing and may influence arousal states. TRN neurons discharge action potentials in two distinct output modes: tonic or burst firing. Burst output, a transient high frequency discharge of action potentials, is dependent on the activation of transient low-threshold voltage-dependent T-type calcium current (IT). In our current study, we identify a broad range of burst firing frequencies in TRN neurons, which depend on the activation of IT. The amplitude of the low-threshold calcium spike (LTS) underlying the burst positively correlated with burst frequency and number of action potentials per burst. Activation of small conductance calcium-activated potassium (SK) channels on TRN neurons can impact burst discharge. Attenuation of SK channels increased TRN neuron burst frequency through an increase in LTS duration, but not magnitude. The broad range of burst firing frequencies could provide distinct downstream inhibition within thalamic nuclei. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

GRAVITY faint: reducing noise sources in GRAVITY ^+ with a fast metrology attenuation system by F. Widmann et al. on Tuesday 13 September With the upgrade from GRAVITY to GRAVITY$^+$ the instrument will evolve into an all-sky interferometer that can observe faint targets, such as high redshift AGN. Observing the faintest targets requires reducing the noise sources in GRAVITY as much as possible. The dominant noise source, especially in the blue part of the spectrum, is the backscattering of the metrology laser light onto the detector. To reduce this noise we introduce two new metrology modes. With a combination of small hardware changes and software adaptations, we can dim the metrology laser during the observation without losing the phase referencing. For single beam targets, we can even turn off the metrology laser for the maximum SNR on the detector. These changes lead to an SNR improvement of over a factor of two averaged over the whole spectrum and up to a factor of eight in the part of the spectrum currently dominated by laser noise. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.05593v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.09.507256v1?rss=1 Authors: Filyushkina, V., Belova, E., Usova, S., Tomskiy, A., Sedov, A. Abstract: The proposed models of segregated functional loops describe the organization of motor control over externally triggered (ET) and internally guided (IG) movements. The dopamine deficiency in Parkinson's disease (PD) is considered to cause a disturbance in the functional loop regulating IG movements. At the same time, the neural mechanisms of movement performance and the role of basal ganglia in motor control remains unclear. The aim of this study was to compare neuronal responses in subthalamic nucleus (STN) during ET and IG movements in PD. We found and analyzed 26 sensitive neurons in 12 PD patients who underwent surgery for implantation of electrodes for deep brain stimulation. We also analyzed the local field potentials (LFP) of the STN of 6 patients in the postoperative period. Patients were asked to perform voluntary movements (clenching and unclenching the fist) evoked by verbal command (ET) or self-initiated (IG). We showed heterogeneity of neuronal responses and did not find sensitive neurons associated with only one type of movement. Most cells were characterized by leading responses, indicating that the STN has an important role in movement initiation. At the same time, we found attenuation of motor responses during IG movement versus stable responses during ET movemements. LFP analysis also showed attenuation of beta desynchronization during multiple IG movements. We propose that stable neuronal response to ET movements is associated with reboot of the motor program for each movement, while attenuation of responses to IG movement is associated with single motor program launching for multiple movements. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

It took 70 episodes, but the Attenuation team finally decided to dive into the world's most popular beer style, the Pale Lager. Learn with your hosts as they explore the (drunk?) history of this crisp, refreshing style that has come to dominate in every corner of the earth. Also, Jason tries two very different Texas beverages and Stephen adds a new story time segment. Beer Tastings: Jason - Montmorency vs Balaton, Jester King Brewing, Austin, TX. Style: Wild Ale with Cherries Stephen - Side Pull, Fair State Brewing Coop/Bierstadt Lagers Collaboration, Minneapolis, MN/Denver, CO. Style: Czech Pale Lager --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

State v. Mykal and Malik DerryConcurrent "dual sovereignty" - definition of "is" - drug dealers convicted in Federal case for discharge of weapon and State court for murder arising out of the same conduct. Slang interpreted by FBI Agent is expert testimony "splashed" equals murdered.State v. RivasInvocation of right to counsel - interrogation must cease. Attenuation analysis is inapplicable.State v. BaileySpousal privilege in case of police officer married to drug dealer.State v. LaneStatute applying mitigating sentencing factor for offenders under 26 applied prospectively.Please consider giving the BOLD SIDEBAR 5-star Rating where you listen to Podcasts. Check out our sound engineer Nick Bates at: Bandcamp -https://nick-bates.bandcamp.com and Twitter -https://twitter.com/nickbatesmusic

Dr. Nero discusses evaluation of  coronary artery disease and coronary inflammaiton with Dr. Cheerag Shirodaria from the University of Oxford.  Dr. Shirodaria along with Prof. Charalambos Antonidies at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary artery lesion, but also how inflamed it is and how likely it is to cause fatal and non-fatal myocardial infarction.  In addition, since it is a biologically active "marker" the Fat Attenuation Index (FAI) can also be used a a way to evaluate success of medical intervention.  Using computer post processing from standard 64 or 128 slice CT coronary angiography, they have been able to evaluate not just the vulnerable patient but also (possibly) the vulnerable plaque.

00:00 from within - The scientific Choice, deadly or infectious00:30 theme song - We've got to do something01:30 infectious disease master man - military suppositories07:00 Holiday protocols - what's a fair ask - know the limits of the COVID test - Know who you're celebrating with10:00 The unvaccinated pandemic - The ongoing of science12:00 Boosters? The Antibody test better explained by smart guys - Know about the numbers - A fold increase future20:00 The bleed over of immunity - One shot to rule them all24:00 Is less deadly safer? - The scientific choice - Delta vs Omicron over the horizon perspectives28:00 How Jeffrey has fun - New vaccines for old diseases - Alzheimers studies in their infancy 30:08 insertion point - beta amyloid - chronic inflammation - teach the immune system to recognize and remove - Phase one is really early43:00 Biotech gene editing - valley fever vaccine innovation and other fun discussions - Lol. I love you Jeffrey45:00 stumbling backwards into live Attenuation - wait for it - what can you define as gene editing? I wanna steak now55:00 misunderstanding science that we couldn't comprehend to begin with - talking through it58:00 when might COVID become something else - will it?1:01.00 Holiday wishes - Have a very Sterile Christmas - Help those without - Have a happy whatever that happy may bePublic Access America Sunday A.M #LiveStream Noon Eastern 9 A.M Pacific 11 A.M Centralhttps://youtu.be/PgQ38hm8_EsApple https://podcasts.apple.com/us/podcast/public-access-america/id1118000423?i=1000515737702@Spotifyhttps://open.spotify.com/episode/589U8kzclmVd3Ny3Dyh3t2?si=q5AWhmzSRX23_AL4mI8Jpg@Stitcherhttps://www.stitcher.com/show/public-access-america@RadioPublichttps://radiopublic.com/public-access-america-WPD3XR@AmazonMusichttps://music.amazon.com/podcasts/36eeac72-@RedCirclehttps://redcircle.com/shows/public-access-americaSupport this podcast at — https://redcircle.com/public-access-america/exclusive-contentAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The first episode in English! But just as in the podcast, we'll start off in Swedish. Vår jäst-gäst Dr. Pat Heist från Wilderness Trail Distillery är här för att lära oss allt om bourbon – från vattnet, jästen och ända till skårorna på utsidan av faten. Häng med! Guest of the episode is Dr. Pat Heist of Wilderness Trail Distillery. He will tell us everything about bourbon making – from the water and yeast to the grooves on the outside of the casks. Join the ride! And if someone out there did not understand the title of the episode… https://www.youtube.com/watch?v=zsqf-ORB37Q (https://www.youtube.com/watch?v=zsqf-ORB37Q) Vad var det i glaset? Mathias hade Bushmills 16 YO. David drack orökigt grönt te. Jeroen hade en Longmorn 16 YO. Dr. Pat Heist Here is an xTED talk (around 10 minutes): https://www.youtube.com/watch?v=oSLWEnz-1mc A wonderfully detailed and nerdy discussion on the production of bourbon which is about 90 minutes long with Bourbon pursuit, a long discussion with Pat: https://www.youtube.com/watch?v=gnzPyFjSSPo Ferm Solutions https://ferm-solutions.net/ Wilderness Trail distillery https://wildernesstraildistillery.com/ Attenuation https://tjederswhisky.se/vad-ar-attenuation/ A little bit about yeast from the viewpoint of Scotch whisky https://scotchwhisky.com/magazine/features/27158/why-scotch-distillers-are-playing-with-yeast/ https://scotchwhisky.com/magazine/ask-the-professor/15315/does-yeast-affect-the-flavour-of-whisky/ https://scotchwhisky.com/magazine/latest-news/27178/whisky-researchers-make-yeast-discovery/ https://scotchwhisky.com/magazine/from-the-editors/8560/baffled-by-yeast/ Reverse osmosis https://en.wikipedia.org/wiki/Reverse_osmosis Oak, seasoning, toasting, charring… https://winemakermag.com/technique/1033-oak-barrel-chemistry-techniques https://thebourbontruth.tumblr.com/post/142198798761/the-truth-about-seasoned-wood Oak can also be dried in a kiln; see this video, ”Bourbon Barrel and Scotch Whisky”, which also has a little information about charring: https://www.youtube.com/watch?v=gq1a6uWH21U Those toasted barrels from Swedish Box distillery, English: https://highcoastwhisky.se/en/products/advanced-master-class/ …and in pdf form: https://highcoastwhisky.se/en/wp-content/uploads/sites/2/2019/04/amc-1-1-english.pdf The company Independent Stave https://www.independentstavecompany.com/ Word of the week: high rye bourbon, wheated bourbon Apart from Pat Heist's exposé, see for example here: https://bourbonveach.com/2017/06/05/what-is-high-rye-bourbon/ https://www.chicagobourbon.org/2017/07/24/what-is-wheated-bourbon/ Corsair distillery https://www.corsairdistillery.com/ Insane in the grain is apparently a twelve-grain whiskey: https://www.whiskybase.com/whiskies/whisky/42953/corsair-artisan-distillery-insane-in-the-grain Ryemageddon: https://www.whiskybase.com/whiskies/whisky/96888/corsair-artisan-distillery-ryemageddon But what about sweet mash and sour mash whiskey? Most information online is very brief indeed, such as here: https://scotchaddict.com/why-does-jack-daniels-call-itself-sour-mash-whiskey.html Här når du oss: En trea whisky på Facebook (https://ww.facebook.com/entreawhisky) Maila till oss på hej@entreawhisky.se Davids blogg tjederswhisky.se (https://www.tjederswhisky.se) Special Guest: Dr. Pat Heist.

This week's episode is a protracted discussion of how environment influences life, and the value of cultures - in yogurt and in life.If you would like more reading on the topic, I can recommend a few articles:Grace Olmsteadhttps://www.frontporchrepublic.com/2021/04/grace-olmstead-on-uprooted-place-idaho-and-prairie-lupines/Preserving Local memory:https://www.frontporchrepublic.com/2010/06/preserving-local-memory/Wanting to preserve your culture is not a bad thinghttps://www.nationalreview.com/2021/08/wanting-to-preserve-your-culture-is-not-a-bad-thing/Visit the website:www.vintageamericanapodcast.comVisit the blog:www.brambleberrymeadow.com

The delta variant of COVID-19 has put the US in the precarious position of a fourth wave of the disease -- how efficacious are our vaccines against this variant? Also, are any new treatments for early COVID-19 being studied to help continue the fight? Find out more in this episode!Redeem your CPE or CME credit here!We want your feedback! Share your feedback and experience with GameChangers! https://www.jotform.com/build/90155144694964References and resources: Thompson MG, Burgess JL, Naleway AL, et al. Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines. N Engl J Med. 2021 Jul 22;385(4):320-329. doi: 10.1056/NEJMoa2107058. Epub 2021 Jun 30. PMID: 34192428; PMCID: PMC8262622.Rossignol J, Matthew C, Oaks J, et al. Early treatment with nitazoxanide prevents worsening of mild and moderate COVID-19 and subsequent hospitalization. medRxiv 2021.04.19.21255441; doi: https://doi.org/10.1101/2021.04.19.21255441Continuing Education Information:Learning Objectives: 1. Discuss the differences in effectiveness between the mRNA and adenovirus vaccines for the delta variant of COVID-192. Describe the use of nitazoxanide in mild to moderate COVID-19 and barriers to its use0.05 CEU | 0.5 HrsACPE UAN: 0107-0000-21-XXX-H01-PInitial release date: 8/31/21Expiration date: 8/24/22Complete CPE & CME details can be found here.

台灣買到第三種新冠疫苗了，忽然有人有想等BNT的想法。我還聽過有人想等根本沒確認買到的Novavax的.... 你莫莫和ZZ都不想打，想等郭董台積電買的瑞瑞嗎？還是你想等端端和亞亞@@ 我建議大家不要等不要選了，輪到你就去打，疫苗打的是群體戰，越多人施打我們面對可能的下一波疫情才能從容應戰！ 你想想，瑞瑞BNT可能九月才會來，來了要檢驗，打完第二劑14天後才會有臨床試驗中號稱的95%保護力，指揮中心搞不好又會規定延長第二劑到10～12週後施打，等你有完整免疫力都已經年底或明年初了！我不想烏鴉嘴，但您確定我們在年底前不會有第二波本土疫情嗎？反之，現在打AZ，第一劑14天後就已經有不錯的保護力了，且延後施打的證據也較完備。 是的，輪到你打就去打吧！大家加油！ 本篇提到的兩篇真實世界顯示的疫苗療效證據： 1.英國公共衛生部（PHE）2021年7月8日的報告 COVID-19 vaccine surveillance report Week 27 https://bit.ly/3B84Zpk 2.美國CDC研究，刊登在2021年6月30日的NEJM Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines https://www.nejm.org/doi/full/10.1056/NEJMoa2107058 給長輩的AZ疫苗懶人包 https://linshibi.com/?p=39590 高端 聯亞 國產疫苗懶人包 第二期結束就緊急授權可行嗎？ https://linshibi.com/?p=39547 新冠快篩懶人包 普篩 抗體快篩 抗原快篩 https://linshibi.com/?p=36564 新冠肺炎疫情下的防疫須知 常見問題解答FAQ https://linshibi.com/?p=35408 新冠疫苗常見問題懶人包 https://linshibi.com/?p=38945 林氏璧醫師的電子名片 https://lit.link/linshibi 歡迎贊助我喝咖啡 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting

In this second installment of the Brownfield Braintrust Podcast, Matt Winefield discusses ten flaws with the Cal-EPA 0.03 attenuation factor (AF) in the Draft Vapor Intrusion Guidance Document. All parties agree that the AF should be based on best available science. Best available science dictates that Cal-EPA must use the AF developed in the 2020 DTSC attenuation factor study, which utilized California data exclusively and has been extensively peer reviewed. Visit Winefield & Associates, Inc. at: https://www.winefieldinc.com/ Find Matt Winefield on LinkedIn at: https://www.linkedin.com/in/mattwinefield/