Podcasts about Formulation

Drs. Hope Rugo, Sheri Brenner, and Mikolaj Slawkowski-Rode discuss the struggle that health care professionals experience when terminally ill patients are suffering and approaches to help clinicians understand and respond to suffering in a more patient-centered and therapeutic way. TRANSCRIPT Dr. Hope Rugo: Hello, and welcome to By the Book, a monthly podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book.  I'm your host, Dr. Hope Rugo. I'm director of the Women's Cancers Program and division chief of breast medical oncology at the City of Hope Cancer Center, and I'm also the editor-in-chief of the Educational Book. On today's episode, we'll be exploring the complexities of grief and oncology and the struggle we experience as healthcare professionals when terminally ill patients are suffering. Our guests will discuss approaches to help clinicians understand and respond to suffering in a more patient-centered and therapeutic way, as outlined in their recently published article titled, “Oncology and Suffering: Strategies on Coping With Grief for Healthcare Professionals.” I'm delighted today to welcome Dr. Keri Brenner, a clinical associate professor of medicine, palliative care attending, and psychiatrist at Stanford University, and Dr. Mikołaj Sławkowski-Rode, a senior research fellow in philosophy in the Humanities Research Institute at the University of Buckingham, where he also serves as director of graduate research in p hilosophy. He is also a research fellow in philosophy at Blackfriars Hall at the University of Oxford and associate professor at the University of Warsaw.  Our full disclosures are available in the transcript of this episode. Dr. Brenner and Dr. Sławkowski-Rode, thanks for being on the podcast today. Dr. Keri Brenner: Great to be here, Dr. Rugo. Thank you so much for that kind introduction. Dr. Mikołaj Sławkowski-Rode: Thank you very much, Dr. Rugo. It's a pleasure and an honor. Dr. Hope Rugo: So I'm going to start with some questions for both of you. I'll start with Dr. Brenner. You've spoken and written about the concept of suffering when there is no cure. For oncologists, what does it mean to attune to suffering, not just disease? And how might this impact the way they show up in difficult conversations with patients? Dr. Keri Brenner: Suffering is something that's so omnipresent in the work of clinical oncology, and I like to begin by just thinking about what is suffering, because it's a word that we use so commonly, and yet, it's important to know what we're talking about. I think about the definition of Eric Cassell, who was a beloved mentor of mine for decades, and he defined suffering as the state of severe distress that's associated with events that threaten the intactness of a person. And my colleague here at Stanford, Tyler Tate, has been working on a definition of suffering that encompasses the experience of a gap between how things are versus how things ought to be. Both of these definitions really touch upon suffering in a person-centered way that's relational about one's identity, meaning, autonomy, and connectedness with others. So these definitions alone remind us that suffering calls for a person-centered response, not the patient as a pathology, but the panoramic view of who the patient is as a person and their lived reality of illness. And in this light, the therapeutic alliance becomes one of our most active ingredients in care. The therapeutic alliance is that collaborative, trusting bond as persons that we have between clinician and patient, and it's actually one of the most powerful predictors of meaningful outcomes in our care, especially in oncologic care.  You know, I'll never forget my first day of internship at Massachusetts General Hospital. A faculty lecturer shared this really sage insight with us that left this indelible mark. She shared, “As physicians and healers, your very self is the primary instrument of healing. Our being is the median of the medicine.” So, our very selves as embodied, relationally grounded people, that's the median of the medicine and the first most enduring medicine that we offer. That has really borne fruit in the evidence that we see around the therapeutic alliance. And we see this in oncologic care, that in advanced cancer, a strong alliance with one's oncologist truly improves a patient's quality of life, treatment adherence, emotional well-being, and even surpasses structured interventions like psychotherapeutic interventions. Dr. Hope Rugo: That's just incredibly helpful information and actually terminology as well, and I think the concept of suffering differs so much. Suffering comes in many shapes and forms, and I think you really have highlighted that. But many oncologists struggle with knowing what to do when patients are suffering but can't be fixed, and I think a lot of times that has to do with oncologists when patients have pain or shortness of breath or issues like that. There are obviously many ways people suffer. But I think what's really challenging is how clinicians understand suffering and what the best approaches to respond to suffering are in the best patient-centered and therapeutic way. Dr. Keri Brenner: I get that question a lot from my trainees in palliative care, not knowing what to do. And my first response is, this is about how to be, not about knowing what to do, but how to be. In our medical training, we're trained often how to think and treat, but rarely how to be, how to accompany others. And I often have this image that I tell my trainees of, instead of this hierarchical approach of a fix-it mentality of all we're going to do, when it comes to elements of unavoidable loss, mortality, unavoidable sufferings, I imagine something more like accompaniment, a patient walking through some dark caverns, and I am accompanying them, trying to walk beside them, shining a light as a guide throughout that darkness. So it's a spirit of being and walking with. And it's so tempting in medicine to either avoid the suffering altogether or potentially overidentify with it, where the suffering just becomes so all-consuming like it's our own. And we're taught to instead strike a balance of authentic accompaniment through it. I often teach this key concept in my palli-psych work with my team about formulation. Formulation is a working hypothesis. It's taking a step back and asking, “Why? Why is this patient behaving in this manner? What might the patient's core inner struggle be?” Because asking that “why” and understanding the nuanced dimensions of a patient's core inner struggle will really help guide our therapeutic interactions and guide the way that we accompany them and where we choose to shine that light as we're walking with them. And oftentimes people think, “Well Keri, that sounds so sappy or oversentimental,” and it's not. You know, I'm just thinking about a case that I had a couple months ago, and it was a 28-year-old man with gastric cancer, metastatic disease, and that 28-year-old man, he was actually a college Division I athlete, and his dad was an acclaimed Division I coach. And our typical open-ended palliative care questions, that approach, infuriated them. They needed to know that I was showing up confident, competent, and that I was ready, on my A-game, with a real plan for them to follow through. And so my formulation about them was they needed somebody to show up with that confidence and competence, like the Division I athletes that they were, to really meet them and accompany them where they were on how they were going to walk through that experience of illness. Dr. Hope Rugo: These kinds of insights are so helpful to think about how we manage something that we face every day in oncology care. And I think that there are many ways to manage this.  Maybe I'll ask Dr. Sławkowski-Rode one question just that I think sequences nicely with what you're talking about.  A lot of our patients are trying to think about sort of the bigger picture and how that might help clinicians understand and support patients. So, the whole concept of spirituality, you know, how can we really use that as oncology clinicians to better understand and support patients with advanced illness, and how can that help patients themselves? And we'll talk about that in two different ways, but we'll just start with this broader question. Dr. Mikołaj Sławkowski-Rode: I think spirituality, and here, I usually refer to spirituality in terms of religious belief. Most people in the world are religious believers, and it is very intuitive and natural that religious beliefs would be a resource that people who help patients with a terminal diagnosis and healthcare professionals who work with those patients appeal to when they try to help them deal with the trauma and the stress of these situations.  Now, I think that the interesting thing there is that very often the benefit of appealing to a religious belief is misunderstood in terms of what it delivers. And there are many, many studies on how religious belief can be used to support therapy and to support patients in getting through the experience of suffering and defeating cancer or facing a terminal diagnosis. There's a wealth of literature on this. But most of the literature focuses on this idea that by appealing to religious belief, we help patients and healthcare practitioners who are working with them get over the fact and that there's a terminal diagnosis determining the course of someone's life and get on with our lives and engaging with whatever other pursuits we might have, with our job if we're healthcare practitioners, and with the other things that we might be passionate about in our lives. And the idea here is that this is what religion allows us to do because we sort of defer the need to worry about what's going to happen to us until the afterlife or some perspective beyond the horizon of our life here.  However, my view is – I have worked beyond philosophy also with theologians from many traditions, and my view here is that religion is something that does allow us to get on with our life but not because we're able to move on or move past the concerns that are being threatened by illness or death, but by forming stronger bonds with these things that we value in our life in a way and to have a sense of hope that these will be things that we will be able to keep an attachment to despite the threat to our life. So, in a sense, I think very many approaches in the field have the benefit of religion upside down, as it were, when it comes to helping patients and healthcare professionals who are engaged with their illness and treating it. Dr. Hope Rugo: You know, it's really interesting the points that you make, and I think really important, but, you know, sometimes the oncologists are really struggling with their own emotional reactions, how they are reacting to patients, and dealing with sort of taking on the burden, which, Dr. Brenner, you were mentioning earlier. How can oncologists be aware of their own emotional reactions? You know, they're struggling with this patient who they're very attached to who's dying or whatever the situation is, but you want to avoid burnout as an oncologist but also understand the patient's inner world and support them. Dr. Keri Brenner: I believe that these affective, emotional states, they're contagious. As we accompany patients through these tragic losses, it's very normal and expected that we ourselves will experience that full range of the human experience as we accompany the patients. And so the more that we can recognize that this is a normative dimension of our work, to have a nonjudgmental stance about the whole panoramic set of emotions that we'll experience as we accompany patients with curiosity and openness about that, the more sustainable the work will become. And I often think about the concept of countertransference given to us by Sigmund Freud over 100 years ago. Countertransference is the clinician's response to the patient, the thoughts, feelings, associations that come up within us, shaped by our own history, our own life events, those unconscious processes that come to the foreground as we are accompanying patients with illness. And that is a natural part of the human experience. Historically, countertransference was viewed as something negative, and now it's actually seen as a key that can unlock and enlighten the formulation about what might be going on within the patient themselves even. You know, I was with a patient a couple weeks ago, and I found myself feeling pretty helpless and hopeless in the encounter as I was trying to care for them. And I recognized that countertransference within myself that I was feeling demoralized. It was a prompt for me to take a step back, get on the balcony, and be curious about that because I normally don't feel helpless and hopeless caring for my patients. Well, ultimately, I discovered through processing it with my interdisciplinary team that the patient likely had demoralization as a clinical syndrome, and so it's natural many of us were feeling helpless and hopeless also accompanying them with their care. And it allowed us to have a greater interdisciplinary approach and a more therapeutic response and deeper empathy for the patient's plight. And we can really be curious about our countertransferences. You know, a few months ago, I was feeling bored and distracted in a family meeting, which is quite atypical for me when I'm sharing serious illness news. And it was actually a key that allowed me to recognize that the patient was trying to distract all of us talking about inconsequential facts and details rather than the gravitas of her illness.  Being curious about these affective states really allows us to have greater sustainability within our own practice because it normalizes that human spectrum of emotions and also allows us to reduce unconscious bias and have greater inclusivity with our practice because what Freud also said is that what we can't recognize and say within our own selves, if we don't have that self-reflective capacity, it will come out in what we do. So really recognizing and having the self-awareness and naming some of these emotions with trusted colleagues or even within our own selves allows us to ensure that it doesn't come out in aberrant behaviors like avoiding the patient, staving off that patient till the end of the day, or overtreating, offering more chemotherapy or not having the goals of care, doing everything possible when we know that that might result in medically ineffective care. Dr. Hope Rugo: Yeah, I love the comments that you made, sort of weaving in Freud, but also, I think the importance of talking to colleagues and to sharing some of these issues because I do think that oncologists suffer from the fact that no one else in your life wants to hear about dying people. They don't really want to hear about the tragic cases either. So, I think that using your community, your oncology community and greater community within medicine, is an important part of being able to sort of process. Dr. Keri Brenner: Yes, and Dr. Rugo, this came up in our ASCO [Education] Session. I'd love to double click into some of those ways that we can do this that aren't too time consuming in our everyday practice. You know, within palliative care, we have interdisciplinary rounds where we process complex cases. Some of us do case supervision with a trusted mentor or colleague where we bring complex cases to them. My team and I offer process rounds virtually where we go through countertransference, formulation, and therapeutic responses on some tough cases.  You know, on a personal note, just last week when I left a family meeting feeling really depleted and stuck, I called one of my trusted colleagues and just for 3 minutes constructively, sort of cathartically vented what was coming up within me after that family meeting, which allowed me to have more of an enlightened stance on what to do next and how to be therapeutically helpful for the case. One of my colleagues calls this "friend-tors." They coined the phrase, and they actually wrote a paper about it. Who within your peer group of trusted colleagues can you utilize and phone in real time or have process opportunities with to get a pulse check on where what's coming up within us as we're doing this work? Dr. Hope Rugo: Yeah, and it's an interesting question about how one does that and, you know, maintaining that as you move institutions or change places or become more senior, it's really important.  One of the, I think, the challenges sometimes is that we come from different places from our patients, and that can be an issue, I think when our patients are very religious and the provider is not, or the reverse, patients who don't have religious beliefs and you're trying to sort of focus on the spirituality, but it doesn't really ring true. So, Dr. Sławkowski-Rode, what resources can patients and practitioners draw on when they're facing death and loss in the absence of, or just different religious beliefs that don't fit into the standard model? Dr. Mikołaj Sławkowski-Rode: You're absolutely right that this can be an extremely problematic situation to be in when there is that disconnect of religious belief or more generally spiritual engagement with the situation that we're in. But I just wanted to tie into what Dr. Brenner was saying just before. I couldn't agree more, and I think that a lot of healthcare practitioners, oncologists in particular who I've had the pleasure to talk to at ASCO and at other events as well, are very often quite skeptical about emotional engagement in their profession. They feel as though this is something to be managed, as it were, and something that gets in the way. And they can often be very critical of methods that help them understand the emotions and extend them towards patients because they feel that this will be an obstacle to doing their job and potentially an obstacle also to helping patients to their full ability if they focus on their own emotions or the burden that emotionally, spiritually, and in other ways the illness is for the patient. They feel that they should be focusing on the cancer rather than on the patient's emotions. And I think that a useful comparison, although, you know, perhaps slightly drastic, is that of combat experience of soldiers. They also need to be up and running and can't be too emotionally invested in the situation that they're in. But there's a crucial difference, which is that soldiers are usually engaged in very short bursts of activity with the time to go back and rethink, and they often have a lot of support for this in between. Whereas doctors are in a profession where their exposure to the emotions of patients and their own emotions, the emotions of families of patients is constant. And I think that there's a great danger in thinking that this is something to be avoided and something to compartmentalize in order to avoid burnout. I think, in a way, burnout is more sure to happen if your emotions and your attachment to your patients goes ignored for too long. So that's just following up on Keri's absolutely excellent points. As far as the disconnect is concerned, that's, in fact, an area in which I'm particularly interested in. That's where my research comes in. I'm interested in the kinds of connections that we have with other people, especially in terms of maintaining bonds when there is no spiritual belief, no spiritual backdrop to support this connection. In most religious traditions, we have the framework of the religious belief that tells us that the person who we've lost or the values that have become undermined in our life are something that hasn't been destroyed permanently but something that we can still believe we have a deep connection to despite its absence from our life. And how do you rebuild that sense of the existence of the things that you have perceivably lost without the appeal to some sort of transcendent realm which is defined by a given religion? And that is a hard question. That's a question, I think, that can be answered partly by psychology but also partly by philosophy in terms of looking at who we are as human beings and our nature as people who are essentially, or as entities that are essentially connected to one another. That connection, I believe, is more direct than the mediation of religion might at first suggest. I think that we essentially share the world not only physically, it's not just the case that we're all here, but more importantly, the world that we live in is not just the physical world but the world of meanings and values that helps us orient ourselves in society and amongst one another as friends and foes. And it is that shared sense of the world that we can appeal to when we're thinking about retaining the value or retaining the connection with the people who we have lost or the people who are helping through, go through an experience of facing death. And just to finish, there's a very interesting question, I think, something that we possibly don't have time to explore, about the degree of connection that we have with other people. So, what I've just been saying is something that rings more true or is more intuitive when we think about the connections that we have to our closest ones. We share a similar outlook onto the world, and our preferences and our moods and our emotions and our values are shaped by life with the other person. And so, appealing to these values can give us a sense of a continued presence. But what in those relationships where the connection isn't that close? For example, given the topic of this podcast, the connection that a patient has with their doctor and vice versa. In what sense can we talk about a shared world of experience? Well, I think, obviously, we should admit degrees to the kind of relationship that can sustain our connection with another person. But at the same time, I don't think there's a clear cutoff point. And I think part of emotional engagement in medical practice is finding yourself somewhere on that spectrum rather than thinking you're completely off of it. That's what I would say. Dr. Hope Rugo: That's very helpful and I think a very helpful way of thinking about how to manage this challenging situation for all of us.  One of the things that really, I think, is a big question for all of us throughout our careers, is when to address the dying process and how to do that. Dr. Brenner, you know, I still struggle with this – what to do when patients refuse to discuss end-of-life but they're very close to end of life? They don't want to talk about it. It's very stressful for all of us, even where you're going to be, how you're going to manage this. They're just absolutely opposed to that discussion. How should we approach those kinds of discussions? How do we manage that? How do you address the code discussion, which is so important? You know, these patients are not able to stay at home at end-of-life in general, so you really do need to have a code discussion before you're admitting them. It actually ends up being kind of a challenge and a mess all around. You know, I would love your advice about how to manage those situations. Dr. Keri Brenner: I think that's one of the most piercing and relevant inquiries we have within our clinical work and challenges. I often think of denial not as an all-or-nothing concept but rather as parts of self. There's a part of everyone's being where the unconscious believes it's immortal and will live on forever, and yet we all know intellectually that we all have mortality and finitude and transience, and that time will end. We often think of this work as more iterative and gradual and exposure based. There's potency to words. Saying, “You are dying within days,” is a lot higher potency of a phrase to share than, “This is serious illness. This illness is incurable. Time might be shorter than we hoped.” And so the earlier and more upstream we begin to have these conversations, even in small, subtle ways, it starts to begin to expose the patient to the concept so they can go from the head to the heart, not only knowing their prognosis intellectually but also affectively, to integrate it into who they are as a person because all patients are trying to live well while also we're gradually exposing them to this awareness of mortality within their own lived experience of illness. And that, ideally, happens gradually over time. Now, there are moments where the medical frame is very limited, and we might have short days, and we have to uptitrate those words and really accompany them more radically through those high-affective moments. And that's when we have to take a lot of more nuanced approaches, but I would say the more earlier and upstream the better. And then the second piece to that question as well is coping with our own mortality. The more we can be comfortable with our own transience and finitude and limitations, the more we will be able to accompany others through that. And even within my own life, I've had to integrate losses in a way where before I go in to talk to one of my own palliative care patients, one mantra I often say to myself is, “I'm just a few steps behind you. I don't know if it's going to be 30 days or 30 years, but I'm just a few steps behind you on this finite, transient road of life that is the human experience.” And that creates a stance of accompaniment that patients really can experience as they're traversing these tragedies. Dr. Hope Rugo: That's great. And I think those are really important points and actually some pearls, which I think we can take into the clinic. I think being really concrete when really the expected life expectancy is a few days to a couple of weeks can be very, very helpful. And making sure the patients hear you, but also continuing to let them know that, as oncologists, we're here for them. We're not abandoning them. I think that's a big worry for many, certainly of my patients, is that somehow when they would go to hospice or be a ‘no code', that we're not going to support them anymore or treat them anymore. That is a really important process of that as well. And of course, engaging the team makes a big difference because the whole oncology team can help to manage situations that are particularly challenging like that. And just as we close, I wanted to ask one last question of you, Dr. Brenner, that suffering, grief, and burnout, you've really made the point that these are not problems to fix but dimensions that we want to attend to and acknowledge as part of our lives, the dying process is part of all of our lives. It's just dealing with this in the unexpected and the, I think, unpredictability of life, you know, that people take on a lot of guilt and all sorts of things about, all sorts of emotions. And the question is now, people have listened to this podcast, what can they take back to their oncology teams to build a culture that supports clinicians and their team at large to engage with these realities in a meaningful and sustainable way? I really feel like if we could build the whole team approach where we're supporting each other and supporting the patients together, that that will help this process immeasurably. Dr. Keri Brenner: Yes, and I'm thinking about Dr. Sławkowski-Rode's observation about the combat analogy, and it made me recognize this distinction between suppression and repression. Repression is this unconscious process, and this is what we're taught to do in medical training all the time, to just involuntarily shove that tragedy under the rug, just forget about it and see the next patient and move on. And we know that if we keep unconsciously shoving things under the rug, that it will lead to burnout and lack of sustainability for our clinical teams. Suppression is a more conscious process. That deliberate effort to say, “This was a tragedy that I bore witness to. I know I need to put that in a box on the shelf for now because I have 10 other patients I have to see.” And yet, do I work in a culture where I can take that off the shelf during particular moments and process it with my interdisciplinary team, phone a friend, talk to a trusted colleague, have some trusted case supervision around it, or process rounds around it, talk to my social worker? And I think the more that we model this type of self-reflective capacity as attendings, folks who have been in the field for decades, the more we create that ethos and culture that is sustainable because clinician self-reflection is never a weakness, rather it's a silent strength. Clinician self-reflection is this portal for wisdom, connectedness, sustainability, and ultimately transformative growth within ourselves. Dr. Hope Rugo: That's such a great point, and I think this whole discussion has been so helpful for me and I hope for our audience that we really can take these points and bring them to our practice. I think, “Wow, this is such a great conversation. I'd like to have the team as a whole listen to this as ways to sort of strategize talking about the process, our patients, and being supportive as a team, understanding how we manage spirituality when it connects and when it doesn't.” All of these points, they're bringing in how we process these issues and the whole idea of suppressing versus sort of deciding that it never happened at all is, I think, very important because that's just a tool for managing our daily lives, our busy clinics, and everything we manage. Dr. Keri Brenner: And Dr. Rugo, it's reminding me at Stanford, you know, we have this weekly practice that's just a ritual where every Friday morning for 30 minutes, our social worker leads a process rounds with us as a team, where we talk about how the work that we're doing clinically is affecting us in our lives in ways that have joy and greater meaning and connectedness and other ways that might be depleting. And that kind of authentic vulnerability with one another allows us to show up more authentically for our patients. So those rituals, that small 30 minutes once a week, goes a long way. And it reminds me that sometimes slowing things down with those rituals can really get us to more meaningful, transformative places ultimately. Dr. Hope Rugo: It's a great idea, and I think, you know, making time for that in everybody's busy days where they just don't have any time anymore is important. And you don't have to do it weekly, you could even do something monthly. I think there's a lot of options, and that's a great suggestion. I want to thank you both for taking your time out for this enriching and incredibly helpful conversation. Our listeners will find a link to the Ed Book article we discussed today, which is excellent, in the transcript of this episode. I want to thank you again, Dr. Brenner and Dr. Sławkowski-Rode, for your time and for your excellent thoughts and advice and direction. Dr. Mikołaj Sławkowski-Rode: Thank you very much, Dr. Rugo. Dr. Keri Brenner: Thank you. Dr. Hope Rugo: And thanks to our listeners for joining us today. Please join us again next month on By the Book for more insightful views on topics you'll be hearing at the education sessions from ASCO meetings and our deep dives on new approaches that are shaping modern oncology. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:      Dr. Hope Rugo @hope.rugo Dr. Keri Brenner @keri_brenner Dr. Mikolaj Slawkowski-Rode @MikolajRode Follow ASCO on social media:      @ASCO on X (formerly Twitter)      ASCO on Bluesky     ASCO on Facebook      ASCO on LinkedIn      Disclosures:     Dr. Hope Rugo: Honoraria: Mylan/Viatris, Chugai Pharma Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx Dr. Keri Brenner: No relationships to disclose Dr. Mikolaj Slawkowski-Rode: No relationships to disclose    

Send us a textWhen traditional dewormers fail against resistant hookworms, veterinarians may turn to emodepside as a last resort. But are all formulations created equal? Not according to recently published research.Join us as Teresa Quintana and Drs. Jeba Jesudoss Chelladurai and Stephanie Martinez reveal critical findings about bioequivalence between different emodepside formulations. Their research demonstrates that the feline topical formulation, when given orally to dogs at 3 mg/kg, produces approximately three times higher peak concentrations and 2.4-2.8 times greater systemic exposure compared to the EU canine modified-release tablet at the same dose.These findings carry significant clinical implications, particularly for dogs with MDR1 mutations lacking P-glycoprotein transport mechanisms. Without this protective system, emodepside can accumulate in the brain and cause neurotoxicity. The research team guides us through proper diagnostic confirmation of resistant hookworms, recommended treatment approaches, and crucial safety considerations before turning to this last-line therapy.The conversation expands into formulation differences, bioavailability challenges, and practical clinical protocols. Teresa, Jeba, and Stephanie emphasize that clients must follow strict fasting guidelines before and after administration, as food dramatically enhances emodepside absorption and could potentially lead to toxicity with the already higher-concentration feline product.Whether you're dealing with suspected resistant hookworms in your practice or simply want to understand the science behind bioequivalence and drug safety, this episode provides essential knowledge for evidence-based clinical decision-making. This episode centers around the intersection of parasitology, pharmacology, and clinical medicine and highlights why the details matter when it comes to drug formulations and routes of administration.AJVR article: https://doi.org/10.2460/ajvr.25.01.0027INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

Summary In this episode of the Future of Dermatology podcast, Dr. Faranak Kamangar and Dr. Tina Bhutani discuss the complexities of topical non-steroidal treatments, particularly focusing on Zoryve (roflumilast). They explore the role of steroids in dermatology, the innovations in non-steroidal treatments, and the importance of understanding genital psoriasis. The conversation highlights the significance of formulation in treatment efficacy and patient compliance, emphasizing the need for awareness and education in dermatological care. Takeaways - Topical non-steroidals are gaining importance in dermatology. - Steroids will always have a role, but their overuse is problematic. - New non-steroidal treatments simplify patient care. - Formulation is key to the effectiveness of topical treatments. - Genital psoriasis is often overlooked but significant. - Patient compliance is crucial for treatment success. - Zoryve offers multiple formulations for different conditions. - Understanding the mechanism of action helps in treatment selection. - Education on genital psoriasis can improve patient outcomes. - Innovative treatments are essential for advancing dermatological care. Chapters 00:00 - Introduction to Topical Non-Steroidals 02:25 - The Role of Steroids in Dermatology 05:58 - Innovations in Non-Steroidal Treatments 10:08 - Understanding Genital Psoriasis 12:32 - Formulations and Indications of Zoryve

Ask the Experts: Formulation by Consultant360

In this episode of Skin Anarchy, host Dr. Ekta Yadav sits down with beauty trailblazer Mikayla Nogueira to dive into the creation of POV Beauty—a skincare line rooted in K-beauty principles, clinical testing, and Mikayla's personal skin journey. From her small-town upbringing to building a brand from scratch, Mikayla opens up about what it really takes to go from content creator to founder.Joining the conversation is Nikki Sokol, POV Beauty's VP of Product Development, whose two decades of experience helped shape the brand's innovative, results-driven formulations.Known for her makeup mastery, Mikayla chose to launch with skincare—because, as she puts it, flawless makeup starts with intentional prep. The line features hydration-first products like Drip It, Drench It, Glaze It, and Amp It, each formulated to work solo or synergistically as a full prep system. With ingredients like fermented rice water, hyaluronic acid, niacinamide, and snow mushroom extract, the formulas reflect Mikayla's love for Korean skincare—but with the clinical rigor of Western labs.She also shares how POV Beauty stands apart from typical influencer brands: through transparency, real testing, and a commitment to quality over hype. The brand name itself—POV—is a nod to inclusivity, reminding us that beauty looks different for everyone.This episode is a candid, behind-the-scenes look at what it takes to build a thoughtful beauty brand in today's saturated market. Whether you're a skincare lover, a beauty entrepreneur, or just curious about what goes into building something from scratch, this conversation is not to be missed. Tune in to hear how Mikayla is rewriting the influencer-to-founder story—one drop at a time.CHAPTERS:(0:00) Introduction and Welcoming Mikayla Nogueira(1:01) Mikayla's Journey from Dreamer to Brand Founder(3:19) The Initial Idea Behind Point of View(5:05) K-Beauty Inspiration and Personal Skin Health Journey(7:28) The Power of Hydration and the Role of K-Beauty in Skin Health(9:39) Key Ingredients in Point of View's Formulation(13:03) The Philosophy Behind the Name "Point of View"(15:57) The Importance of Skin Prep Before Makeup(27:11) The Key to Flawless Makeup: Proper Skin Prep and ExfoliationTo learn more about POV Beauty, visit their website and social media.To learn more about Mikayla, visit her social media.Please fill out this survey to give us feedback on the show!Don't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf! Hosted on Acast. See acast.com/privacy for more information.

In today's episode, supported by Shorla Oncology, we had the pleasure of speaking with Kate Gasparini, PharmD, BCOP, BCPPS, about the use of the oral formulation of imatinib (Imkeldi) for pediatric and adult patients with select leukemias and other malignancies. Gasparini is a pediatric oncology clinical pharmacy specialist at Memorial Sloan Kettering Cancer Center in New York, New York. In our exclusive interview, Gasparini discussed her role as a clinical pharmacy specialist in pediatric oncology, emphasizing her work in patient care, medication reviews, and supportive care. She also noted challenges in administering treatments to patients with dysphagia and emphasized the need for liquid formulations of common therapies. She explained the significance of the availability of the liquid formulation of imatinib, sharing its benefits for patients who struggle with swallowing. Gasparini also addressed potential barriers to accessing this medication, such as insurance coverage limitations, as well as the importance of considering the volume and palatability of liquid formulations to avoid adverse effects and ensure treatment adherence.

Check out our recap and breakdown of Season 4 Episode 16 of the Big Bang Theory! We found 3 IQ Points!00:00:00 - Intro00:07:07 - Recap Begins00:07:33 - Sex Sounds! 00:28:30 - The Hindu code of Manu00:47:50 - Drug Sniffing German Shepherds Find us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) Music by Alex Grohl. Find official podcast on Apple and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

In this conversation, David Jacobowitz, founder of Nebula Snacks, shares his journey from a childhood filled with sweets to creating a line of luxurious, sugar-free chocolate bites. He discusses the challenges of managing his health, the experimentation process behind developing his products, and the ways in which customer feedback helps shape his brand and product line. David emphasizes the importance of taste in healthy snacks and the benefits of using natural sweeteners that do not spike blood sugar, making his products suitable for those with dietary restrictions. He shares valuable lessons learned from his digital marketing background, emphasizes the significance of maintaining healthy profit margins while growing a CPG company, and the importance of maintaining personal involvement in all aspects of the business.  David wraps up by advocating for a positive relationship with food, because food is meant to be enjoyed, not feared.Takeaways:David's childhood nickname was 'the vacuum' due to his insatiable appetite.He faced obesity and potential diabetes at a young age, leading to a long phase of fad dieting.During COVID, he began experimenting with making his own sugar-free chocolate to get his sweet snacking under control.David aimed to create a product that didn't compromise on taste while being healthier.He used monk fruit and allulose as sweeteners to avoid the aftertaste common in other sugar-free products.The development of his chocolate took years of experimentation and customer feedback.He initially launched with full-size chocolate bars before transitioning to smaller filled cups.Mint chocolate became a top seller despite David's original dislike for that flavor.Customer feedback played a crucial role in flavor development and product offerings.David's products are designed to not spike blood sugar, making them suitable for most diabetics, though different individuals have unique blood sugar responses.Manufacturing challenges can be significant for startups.Protecting profit margins is essential to sustain a business.Pricing should be based on actual costs, not market feelings.Food should be enjoyed, not feared.Transparency in food ingredients is increasingly important.Sound Bites:“The doctor said I was obese, at 10 years old, and I was heading towards diabetes.""I own a Zero sugar chocolate company, but I do still have some sugar.”"You can have a better-for-you product, but if it doesn't taste good, you're solving nobody's issue. Taste matters"“I can't give a hundred percent guarantee that it won't spike your blood sugar because everybody's blood sugar is unique.”“At the end of the day you gotta listen to the customer. They're requesting flavors, they're requesting products, those are the ones I'm gonna be launching.”“Until you reach a certain point, do everything yourself. It's gonna suck, but you will become far more appreciative, learn the ins and outs a lot quicker, and be able to establish firm relationships with your customers."“Protect your margin because once you actually hit scale, particularly in retail, you're going to need it.""Don't price based on feeling and market comps alone. Know your numbers.”"Snacking is my superpower.""Food is meant to be enjoyed, not feared.""The consumer's wisening up, and that's what we're really all about.”Links:David Jacobowitz on LinkedIn - https://www.linkedin.com/in/davidjacobowitz/Nebula Snacks - https://nebulasnacks.com/Nebula Snacks on LinkedIn - https://www.linkedin.com/company/nebula-snacks/Nebula Snacks on Facebook - https://www.facebook.com/nebulasnacksNebula Snacks on Instagram - https://www.instagram.com/nebulasnacksNebula Snacks on X - https://x.com/nebulasnacksNebula Snacks on TikTok - https://www.tiktok.com/@nebulasnacks…Brands for a Better World Episode Archive - http://brandsforabetterworld.com/Brands for a Better World on LinkedIn - https://www.linkedin.com/company/brand-for-a-better-world/Modern Species - https://modernspecies.com/Modern Species on LinkedIn - https://www.linkedin.com/company/modern-species/Gage Mitchell on LinkedIn - https://www.linkedin.com/in/gagemitchell/…Print Magazine Design Podcasts - https://www.printmag.com/categories/printcast/…Heritage Radio Network - https://heritageradionetwork.org/Heritage Radio Network on LinkedIn - https://www.linkedin.com/company/heritage-radio-network/posts/Heritage Radio Network on Facebook - https://www.facebook.com/HeritageRadioNetworkHeritage Radio Network on X - https://x.com/Heritage_RadioHeritage Radio Network on Instagram - https://www.instagram.com/heritage_radio/Heritage Radio Network on Youtube - https://www.youtube.com/@heritage_radioChapters:03:00 - The Sweet Beginnings: David's Journey with Sweets05:39 - From Fad Diets to Sustainable Solutions07:59 - Crafting the Perfect Sugar-Free Chocolate12:00 - Experimentation and Flavor Development18:44 - Customer Feedback and Flavor Evolution24:23 - Understanding Blood Sugar and Health Benefits34:28 - Understanding Blood Sugar and Snacking35:41 - Customer-Centric Product Development37:12 - The Challenges of Manufacturing40:19 - Lessons from Digital Marketing Experience42:37 - Key Lessons from Three and a Half Years45:54 - Advice from CPG Leaders53:37 - Personal Snacking Preferences57:53 - A Better World Through Food01:03:37 - Closing Thoughts and Future Aspirations

Was Hunter really running the White House? He played Biden a few times. Here's why we don't believe it. Ron Klain was in charge of Ebola, the auto pen, plus he was chief of staff. Liz Warren is bigger than you think. Pay attention to the silence gaps. Anita Dunn was heavily involved, and has ties to Obot. So much money was made on the side. Big news coming from NATO. The old guard has been largely dismantled. Dims do it to themselves. Conspiracy theory cultists. Eco terrorism should be carefully watched by all. Congress is not doing what they are supposed to do. Desperation makes them pull out all the stops. Doing good for the country gets you destroyed. Now, we will see the concerning pockets of action. Hunter's is the fall guy. Anti Trump narrative is raging. People on the right are caught up in tax graft of all kinds. Trust now comes hard. J6 was an operation. There are just two reasons for proximity. Karen, Anita and Harry. All Dunn's. June is not going to be nice. Have faith. This has all been orchestrated. It's not looking good for a lot of people. Remember, it's above us to gloat, and always remain focused on pursuing the truth.

I’m joined by Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands and the team behind Melrose Future Lab. Neal leads a thought-provoking conversation on ageing, vitality, and the science behind what really works. We unpack the difference between lifespan and health span—because it’s not just about living longer, but living well. From cellular senescence to musculoskeletal strength, we look at ingredients leading wellness conversations and the future of longevity science. Neal also lifts the lid on supplement quality, why not all extracts are created equal, and explains the concept of bioavailability to actually move the needle. If you’re navigating perimenopause, curious about longevity, embarking on strength training, or trying to make sense of the supplement aisle, this episode will help you cut through the noise and make informed, future-focused choices. In partnership with Melrose Future Lab. Key Takeaways: Health span means more years lived well, not just longer Cellular senescence (aka “zombie cells”) reduces function as we age Berberine can support healthy blood glucose and AMPK activation Quality matters: not all herbal extracts or proteins are created equal Collagen, especially bovine-derived, supports muscle health Strength training is essential for bone density in menopausal women Supplement bioavailability is as important as the ingredients themselves Innovative formulations are changing how we absorb nutrients Menopause research is decades behind other women’s health areas Perimenopausal women benefit from tailored support and active nutrients Intermittent fasting and autophagy support cellular repair Effective supplements are about formulation—not fads Chapter: 00:00 – The Importance of Health Span vs Longevity03:05 – Understanding the Hallmarks of Ageing05:58 – Cellular Mechanisms of Ageing and Longevity09:12 – The Role of Supplements in Ageing Well11:59 – Berberine: A Key Player in Longevity15:02 – Navigating the World of Supplements18:02 – The Future of Health and Wellness26:32 – Musculoskeletal Health and Ageing34:00 – Innovations in Formulation and Bioavailability38:01 – Addressing Menopause and Perimenopause45:23 – The Importance of Formulation Over Ingredients Watch the full episode here: https://youtu.be/i65uno_HZQoSee omnystudio.com/listener for privacy information.

Have you been studying herbs for a while, but you still feel unsure about how to combine them into an effective formula?  Or maybe you're newer to herbalism and ready to dive into the art and science of formulation? Formulation is one of my favorite parts of herbal medicine, so I'm excited to kick off a new series called The Anatomy of a Formula. I love the synergy that emerges when herbs are combined in intelligent, intentional ways—and the specificity you can achieve when formulating for a particular person. It's both powerful and fun. However, for budding herbalists, formulation can initially feel daunting and a little confusing. Without some kind of framework or guidance, many people end up just tossing a bunch of herbs into a bottle and hoping it works. That's not an ideal approach because you're essentially leaving your therapeutics to chance. Instead, approach formulation with strategy, intention, and precision, tailored to the individual you're working with.  Here's what we'll cover in this post: • A brief history of formulation in North American herbalism • Formulation challenges and how to fix the problem • The foundations of herbal formulas: pairs and triplets • The anatomy of an effective formula     ———————————— CONNECT WITH SAJAH AND WHITNEY ———————————— To get free in depth mini-courses and videos, visit our blog at:  http://www.evolutionaryherbalism.com   Get daily inspiration and plant wisdom on our Facebook and Instagram channels: http://www.facebook.com/EvolutionaryHerbalism https://www.instagram.com/evolutionary_herbalism/   Be sure to subscribe to our YouTube Channel: https://www.youtube.com/channel/UCyP63opAmcpIAQg1M9ShNSQ   Get a free 5-week course when you buy a copy of the book, Evolutionary Herbalism: https://www.evolutionaryherbalism.com/evolutionary-herbalism-book/   Shop our herbal products:  https://naturasophiaspagyrics.com/   ———————————— ABOUT THE PLANT PATH ———————————— The Plant Path is a window into the world of herbal medicine. With perspectives gleaned from traditional Western herbalism, Ayurveda, Chinese Medicine, Alchemy, Medical Astrology, and traditional cultures from around the world, The Plant Path provides unique insights, skills and strategies for the practice of true holistic herbalism. From clinical to spiritual perspectives, we don't just focus on what herbs are "good for," but rather who they are as intelligent beings, and how we can work with them to heal us physically and consciously evolve.   ———————————— ABOUT SAJAH ———————————— Sajah Popham is the author of Evolutionary Herbalism and the founder of the School of Evolutionary Herbalism, where he trains herbalists in a holistic system of plant medicine that encompasses clinical Western herbalism, medical astrology, Ayurveda, and spagyric alchemy. His mission is to develop a comprehensive approach that balances the science and spirituality of plant medicine, focusing on using plants to heal and rejuvenate the body, clarify the mind, open the heart, and support the development of the soul. This is only achieved through understanding and working with the chemical, energetic, and spiritual properties of the plants. His teachings embody a heartfelt respect, honor and reverence for the vast intelligence of plants in a way that empowers us to look deeper into the nature of our medicines and ourselves. He lives on a homestead in the foothills of Mt. Baker Washington with his wife Whitney where he teaches, consults clients, and prepares spagyric herbal medicines.    ———————————— WANT TO FEATURE US ON YOUR PODCAST? ———————————— If you'd like to interview Sajah or Whitney to be on your podcast, click here to fill out an interview request form.

► Die Arno-Stern-Ausbildung, mit den Original-Inhalten, von Arno Stern vorbereitet – eine prägende, lebensverändernde Erfahrung:https://go.veitlindau.com/arno-stern-ausbildung-malspiel► In dieser besonderen Episode des HUMAN FUTURE MOVEMENT Podcasts habe ich die Freude, mit einem Menschen zu sprechen, der für mich selbst immer wieder wie ein Fenster in eine alternative Realität wirkt: André Stern.André ist nie zur Schule gegangen – und genau das macht seine Sicht auf Lernen, Kreativität und das Menschsein so kostbar. Er ist ein leuchtendes Beispiel dafür, was möglich ist, wenn ein Kind nicht unterbrochen wird. Wenn es in seinem natürlichen Rhythmus wachsen darf. Wenn Begeisterung der Leitstern ist – nicht Leistung, nicht Vergleich, nicht Bewertung.Gemeinsam tauchen wir tief ein in das Lebenswerk seines Vaters Arno Stern – dem Erfinder des Malorts und Entdecker der Formulation. In diesem Gespräch erfährst du, warum der Malort nicht einfach nur ein Raum zum Malen ist, sondern ein heilsamer Ort der Freiheit. Ein geschützter Raum jenseits von Erwartung und Beurteilung, in dem sich Kinder und Erwachsene in ihrer wahren Schöpferkraft erleben dürfen.André erzählt mit großer Wärme und Authentizität davon, wie sein Vater mit nichts als Papier, Farben und Vertrauen eine Revolution im Verständnis kindlicher Entwicklung auslöste – und wie dieses Erbe heute weiterlebt.Wenn du dich nach mehr Tiefe, nach echter Verbindung, nach einem neuen Blick auf Kreativität und Menschsein sehnst, dann wird dich dieses Gespräch berühren und inspirieren.In Verbundenheit,Veit

Cats are so misunderstood by pet parents, even more so than dogs in my opinion. They have very specific needs that we (mostly) don't meet. In this episode, I'm joined by Sabrina from RAWR Pet Food (Eat Like A Lion) to talk all things feline nutrition—from ethical sourcing to species-appropriate formulation. If you've ever wondered what your cat actually needs to thrive, this episode breaks it down with clarity and truth.Send us a text

In today's episode, supported by Azurity Pharmaceuticals, we spoke with Michael J. Mauro, MD, about treatment adherence with nilotinib (Tasigna/Danziten) in patients with Philadelphia chromosome (Ph)–positive chronic myeloid leukemia (CML). Dr Mauro is an attending physician at Memorial Sloan Kettering Cancer Center in New York, New York. In our exclusive interview, Dr Mauro discussed barriers to nilotinib treatment adherence in patients with Ph-positive CML, ways that nonadherence can diminish quality of life and clinical response to treatment, ways that the new formulation of nilotinib addresses adherence issues by reducing the need for fasting, and ongoing research into alternative formulations of other agents that may further improve CML treatment efficacy and tolerability.

On this eye-opening episode of Vitality Radio, Jared breaks down the part of the supplement label most people ignore: other Ingredients. While active ingredients get all the attention, it's often the excipients—binders, fillers, flow agents, coatings, and colorants—that determine whether your supplement is truly clean and effective. Jared exposes why manufacturers use these "inactive" ingredients, how they impact product quality, and which common additives you should avoid. You'll learn how to read this overlooked section of your supplement label and become an informed, empowered consumer.Additional Information:#525: Decoding Supplement Fact Panels and Becoming a More Informed ConsumerOther Ingredients Breakdown Blog PostVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Join hosts Ed Voccola (Rick and Morty, Bless The Harts) and Chris Cullari (Blumhouse, The Aviary) for a wild trip through the world of what scares them. This week, the boys lose their minds on a meth bender through time and space. From the origins of the drug in the reeds of a 125 million year old plant, to its powerful effects on the body and mind, to a tale of a trip so wild it borders on the supernatural, this episode just might keep you up for days. Don't love every word we say? Ok, weirdo. Here's some "chapters" to find what you DO love: 00:00:00 - Intro 00:01:32 - 5-Star Reviews, Letter From a Fan, Producer Roll Call 00:09:25 - We're Talking Meth 00:14:16 - What is Meth 00:21:42 - History of Meth 00:40:05 - Formulation of Meth 00:42:40 - WWII Meth 00:49:37 - Post-War Meth 01:02:56 - Math and Meth 01:13:31 - Super Meth 01:19:11 - Meth Psychosis 01:22:38 - Albert John Ackerman 01:34:22 - St. Jimmy's Meth Psychosis 01:49:45 - The Fear Tier NOTE: Ads out of our control may affect chapter timing. Visit this episode's show notes for links and references. And the show notes for every episode can now be found on our website. Want even more out of SATT? You can SUPPORT THE SHOW and grab yourself ad-free episodes, a welcome button, and more by joining SATT PREMIUM.

In this episode of Ag Tech Talk by AgriBusiness Global, Jim Beneke, Vice President of Tria Americas discusses how adaptive artificial intelligence and edge computing are driving advancements in agriculture, particularly through autonomous machinery and smart systems that operate with limited connectivity.

Tired of gimmicky supplements that promise everything but deliver nothing? Kyal Van Der Leest reveals how he builds potent, bioharmonized formulas using cutting-edge peptides, botanicals, & smart delivery systems. From gut & brain optimization to detox support, this episode shows how advanced ingredients paired with ethical practices raise the bar for results you can feel Meet our guest Kyal Van Der Leest is a Nutritionist, Naturopath & Functional Health Coach turned supplement formulator He founded LVLUP Health to create the kinds of products he wished he had access to during his clinical practice, retail experience & personal health journey. LVLUP's formulas blend evidence-based nutrition, functional medicine & various health modalities—targeting root causes & supporting multiple biochemical pathways With a results-driven approach, Kyal designs supplements that actually work as promised, offering effective tools for those seeking real, lasting wellness Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Peptides enhance supplements by targeting specific functions & boosting natural health Innovate beyond standard formulas using unique processes for effective, natural products Use clinically effective doses to ensure safety & optimize health benefits Avoid proprietary blends—transparency in ingredients & dosages builds trust & effectiveness Liposomal delivery boosts nutrient absorption & improves product stability Regular testing guides personalized supplementation & ensures optimal health Invest in quality over cost—cheap supplements often compromise purity & results Enhance bioavailability to ensure efficient nutrient absorption & effectiveness Tailor supplement stacks to individual needs & responses for better results Use nootropics wisely—cycle them to prevent dependency & support brain health 80% of products on Amazon don't meet the dosage they claim to deliver & 20% of them also don't have the actives they actually claim to possess BPC-157 in acetate form (without the arginate salt or special buffering) gives about "30 to 40 percent" oral absorption Episode Highlights 12:52 How to Decide Supplement Dosages 20:50 Comparing Studies vs. Anecdotes for Ingredients 27:56 Issues With Supplement Quality, Safety & Fake Reviews 30:29 Gut Health's Role in Peptide Absorption 40:32 Choosing Functional Fillers Over Cheap Additives 48:59 Complex Nootropics vs. Basic Staples 57:18 Self-Assessment & Lab Testing With Stacks Links Watch it on YouTube: https://youtu.be/DEvDKPtwk6Q  Full episode show notes: outliyr.com/208 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Educator Patty Gómez used a question formulation technique to cultivate a collaborative culture of curiosity at work. Theme music by Sean Balick; “Entrance Shaft 11” by The Depot, via Blue Dot Sessions.

A new beef cattle feeding science has been 30 years in the making.

This week we talk about the return of Priya, home security and cameras, when it's okay to prioritize your parents in a relationship, and more!Download hereRunning time: 1:07:19, 48.6 MB

In this conversation, Michael Fisher, founder and CEO of Rotten, shares his journey of building a candy brand from scratch with zero experience in the industry. He talks about the initial trap that many startup CEOs fall into, himself included, of chasing the symbols of success instead of focusing on the business fundamentals. Michael then shares his personal connection to candy and the creative process behind building a brand narrative that emotionally resonates with consumers. During the conversation, we touch on the power of learning from advisors, the role of Kickstarter in validating his product concept, and his focus on healthier ingredients while maintaining great taste. Michael also shares insights on creative collaboration, the challenges of competing in the candy industry, including navigating legal issues with larger brands, and his vision for a better world through diverse product options.Key points from this episode:Transitioning from a startup CEO mindset to a real business is crucial.Learning from advisors and networking is key to success.Kickstarter served as a validation tool for Rotten's concept.A personal connection to candy inspired the brand's focus.Building a brand narrative is essential in a competitive market.World-building with engaging characters enhances brand identity through rich and engaging storytelling.The candy industry is brand-dominated, requiring strong branding to compete for loyalty.A significant portion of consumers are purchasing less candy due to health concerns.The brand aims to attract consumers who have never purchased better-for-you candy before.Formulation challenges are common when creating healthier candy options.The brand has undergone multiple reformulations to improve product quality.Legal challenges from larger brands can be daunting, but also indicate market presence.The goal is to provide consumers with better options that taste great.A better world means offering diverse food options, including healthier choices. Sound Bites:"It's really hard to remember that there isn't a playbook. What's going to work for your brand is going to be a unique path.""I stopped buying a lot of candy, actually, and I missed it. I missed the experience of eating candy.”"I really wanted to have a focus on building a strong brand that people could love.""We have worlds that haven't been explored, you know, Freektopia and all these fun places.”“More than a third of consumers in our category, non-chocolate candy, reported purchasing less candy over the last year. And the number one reason they report that is health and diet concerns."“We are showing that there is demand from people and people are willing to pay a premium for candy that still tastes incredible and gives them some of these health benefits.”“We're gonna win here is if someone eats our candy and it's their favorite candy, regardless of the health benefits.""So that was a fun time for me to play around in my kitchen, but I quickly learned that it's a very technical product to make." Links:Michael Fisher on LinkedIn - https://www.linkedin.com/in/michael-fisher1/Rotten - https://eatrotten.com/Rotten on Instagram - https://www.instagram.com/eatrotten/Rotten on Tiktok - https://www.tiktok.com/@eatrottenRotten on YouTube - https://www.youtube.com/@eatrottenRotten on LinkedIn - https://www.linkedin.com/company/eatrotten/posts/…Dr James Richardson - Evolve CPG episode 74 - https://modernspecies.com/brands-for-a-better-world-podcast/focus-on-your-fans-dr-james-richardson-premium-growth-solutions?rq=rampingRamping Your Brand Book - https://www.rampingyourbrand.com/…Brands for a Better World Episode Archive - http://brandsforabetterworld.com/Brands for a Better World on LinkedIn - https://www.linkedin.com/company/brand-for-a-better-world/Modern Species - https://modernspecies.com/Modern Species on LinkedIn - https://www.linkedin.com/company/modern-species/Gage Mitchell on LinkedIn - https://www.linkedin.com/in/gagemitchell/…Print Magazine Design Podcasts - https://www.printmag.com/categories/printcast/…Heritage Radio Network - https://heritageradionetwork.org/Heritage Radio Network on LinkedIn - https://www.linkedin.com/company/heritage-radio-network/posts/Heritage Radio Network on Facebook - https://www.facebook.com/HeritageRadioNetworkHeritage Radio Network on X - https://x.com/Heritage_RadioHeritage Radio Network on Instagram - https://www.instagram.com/heritage_radio/Heritage Radio Network on Youtube - https://www.youtube.com/@heritage_radio Chapters: 03:00 Introduction to Michael Fisher and Rotten06:09 The Transition from Startup CEO to Real Business08:49 Learning the CPG Landscape12:00 The Role of Advisors and Networking14:59 Kickstarter: A Launchpad for Validation18:11 Personal Connection to Non-Chocolate Candy21:05 Building a Brand with a Narrative23:55 World Building in Brand Development28:31 Creative Collaboration in Candy Design31:49 Building Emotional Connections with Consumers33:01 Competing in the Candy Industry39:05 Formulation Challenges and Product Development47:42 Navigating Legal Challenges with Big Candy53:39 A Vision for a Better World through Options

This episode was recorded at the 2025 Florida Ruminant Nutrition Symposium. Panelists Dr. John Goeser or Rock River Laboratory, Inc.; Dr. Bob Kozlowski, PAS of Dairy NExT, LLC and Dr. Tom Overton of Cornell University introduce themselves and give an overview of their backgrounds. (0:10)Dr. Goeser begins with three different ways to define forage quality: energetic potential, particle size as an interaction factor, and anti-nutritional components. He asks Dr. Kozlowski if these are the hot topics for his consulting clients. (6:53)When evaluating the energy potential in feed, Dr. Goeser states there's nothing new as far as measuring the nutrient content of feeds, but capturing the nutrient digestion potential in fiber, starch, and fatty acids is an area where we could stand to make sizable strides. We've been studying fiber and starch digestion for more than 50 years, and they're still really hard to measure because nutrient digestion potential is not linear. In the laboratory, ruminal fiber digestion is measured at many different time points to create curves, but if we want to get a good handle on the energy potential in feeds, we need to take a total digestible nutrients approach.  (9:31)Dr. Goeser feels there are more similarities between laboratories in quantifying fiber digestion potential, but there is little agreement among labs for starch digestion. Research shows that seven hour starch digestion is dramatically affected by laboratory technique and starch digestion curves also vary widely among labs. Dr. Overton commends the lab for diligently working to understand these dynamics. (14:31)From a fiber standpoint, Dr. Kozlowsk states that uNDF has probably been one of the most significant improvements in the tools he has to work with. He gives an example of cows on a 45% forage diet in the Southeast and cows on a 60% forage diet in the Northeast, both with similar uNDF concentrations. Those two groups of cows perform very similarly in terms of volume, fat and protein. (18:43)Dr. Overton asks both guests for their take on feed hygiene. Dr. Goeser feels that there is at least 10 times more to learn about feed hygiene compared to fiber and starch digestibility. Merging veterinary diagnostics with commercial nutrition laboratory work shows promise for solving undesirable mold, yeast, mycotoxin and bacteria issues in feeds. In case studies, he states there is never just one issue at play; there are two or three that may have negative associative effects with one another. Dr. Kozlowski has been seeing varietal-dependent corn silage DON toxin levels in the last few years. Dairies are now looking at all aspects of the agronomy program in addition to all the other assessments of NDF digestibility and starch. (20:33)Dr. Goeser goes on to describe some work on large dairies where they're finding hidden nutrient variation and starch and protein flux that happens within a 1-2 week period that we aren't able to capture with our current sampling techniques. For dairies feeding 2,000-15,000 cows, a diet formulation is on point today, but within that 1-2 week period at the volume of feed they're going through, the diet is now out of spec. However, it's not so out of line that the cows are giving feedback in terms of components or deviation in production or intake. (30:08)On the cow side, new technologies like SCR are allowing insights into rumination dynamics, which can be applied to feed formulation. Some silage choppers now have NIR units measuring silage quality during harvest. The panelists discuss what other technologies might be on the horizon, including on-farm NIR units on front-end loaders or mixer trucks. Dr. Goeser mentions some of the challenges with these technologies, including feed moisture levels interfering with equipment and lack of trust in technologies. (34:21)The panelists close out the episode with their take-home messages. (42:03)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

In this episode of The Pet Food Science Podcast Show, Dr. James Templeman and Lindsay Meyers from Primal Pet Foods break down the science behind creating complete and balanced raw diets for pets. They talk about the challenges of getting micronutrients right, dealing with ingredient variability, and why solid research matters in pet food. Hear how innovation, testing, and careful formulation work together to keep pets safe and well-nourished. Listen now on all major platforms!"Raw and minimally processed pet foods have gained popularity due to their natural look, but balancing their nutritional composition requires careful formulation." - Dr. James TemplemanMeet the guests: Dr. James Templeman holds a Ph.D. in Animal Nutrition and is Director of Nutrition and Formulation at Primal Pet Foods. He also serves as an Adjunct Professor at the University of Guelph, focusing on protein quality models and pet diet formulation.Lindsay Meyers, BS CVT, is Vice President of Quality, Nutrition, and Compliance at Primal Pet Foods. With over 15 years in veterinary medicine, she specializes in quality assurance, regulatory compliance, and nutritional development for minimally processed pet food formulations.What will you learn:(00:00) Highlight(01:02) Introduction (03:04) Formulating raw diets (06:07) Ingredient variability (10:18) Micronutrient sourcing (16:10) Scientific pet food research (24:04) Product innovation (37:16) Final QuestionsThe Pet Food Science Podcast Show is trusted and supported by innovative companies like:* Trouw Nutrition* Kemin- EW Nutrition- ICC- Scoular- Biorigin- Symrise

In this inspiring episode of The Retail Pilot: Leaders & Legends, host Ken Pilot sits down with EGOT-winning artist and entrepreneur John Legend, alongside brand builder Ari Bloom, co-founder and CEO of A-Frame Brands. Together, they unpack the story behind their inclusive skincare line Loved01—a brand created with intention, affordability, and care for melanin-rich and sensitive skin.John shares how his dual passion for music and academics shaped his career, why love is the foundation of everything he creates, and what it's like building a brand with his longtime stylistic and creative team. Ari details the strategy behind launching socially conscious brands through A-Frame, lessons from live selling on QVC and Amazon, and how the data is shaping their next moves.

Send Vanessa a Text MessageListener Discount Code: INTENTIONALLY10 for 10% off purchase (Glutathione)Link to shop: https://aurowellness.com/?ref=1733Glutathione—often called the “master antioxidant”—plays a crucial role in detoxification, disease prevention, immune function, and overall health. In this episode, I sit down with Dr. Nayan Patel to break down what glutathione is, why it's essential, and how to optimize your levels naturally and through supplementation. Dr. Nayan is a renowned pharmacist, the author of the book 'The Glutathione Revolution,' and the founder of Auro Wellness. Whether you're looking to improve energy, reduce oxidative stress, support liver health, or promote slower aging, this episode covers everything you need to know.Some of what's discussed:What is glutathione and why is it important?The role of glutathione in detoxification and immune supportNatural ways to boost glutathione (diet, lifestyle)Glutathione depletion—what actually lowers your levels?Supplementation: Who needs it, who doesn't, and why 99% of the glutathione supplementation on the market is not very effectiveCommon misconceptions and mistakes people make with glutathioneTips for travel: How flying deceases levels and what you can do about itGuest Resources:Shop glutathione: https://aurowellness.com/?ref=1733 Auro Wellness on Instagram: https://www.instagram.com/aurowellness/Dr. Nayan Patel's Book: https://a.co/d/bbggrI3Podcast Resources:Discount codes/affiliate links: https://linktr.ee/thegiftofgoodsPodcast on Instagram: https://www.instagram.com/well.with.vanessa/Podcast on YouTube: www.youtube.com/@IntentionallyWellPodcastVanessa on Instagram: https://www.instagram.com/thegiftofgoods/ Vanessa on Threads: https://www.threads.net/@thegiftofgoodsPodcast on TikTok: https://www.tiktok.com/@well.with.vanessaPodcast on X: https://x.com/wellwithvanessaEmail: intentionallywellpodcast@gmail.comSupport the showPodcast Website: https://intentionallywellwithvanessalopez.buzzsprout.comThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Making sense of your eating disorder through psychological formulation If you're lost in the jungle of your eating disorder, without a map to guide you safely, you probably feel intense confusion and overwhelm. Why can't I just eat normally? Why the constant obsessions with food? What is wrong with me? You likely feel terribly alone. To begin to unravel the tangled ed vines that have wrapped themselves tortuously around you, and to shed some awareness and understanding of the complexity of the issue, therapists sometimes use the tool of psychological formulation. Psychological formulation aims to piece together the different parts of the jigsaw, to bring light and clarity. It provides a zoom-out perspective of the eating disorder, as a coping strategy. It peels back the different layers of the psychological onion offering insights and hope around change. In this episode, I explore a psychological formulation and how you can use this as a tool in therapy. I hope that you find it helpful.   Harriet's Substack: https://substack.com/@theeatingdisordertherapist   Harriet Frew's current offers: - Online 10 Steps to Intuitive Eating Course https://www.theeatingdisordertherapist.co.uk/online-courses.html Online Breaking Free from Bulimia  https://www.theeatingdisordertherapist.co.uk/bulimia-nervosa-online-course.html Eating Disorders Training for Professionals https://www.theeatingdisordertherapist.co.uk/eating-disorders-training-with-harriet-frew.html Body Image Training for Professionals https://www.theeatingdisordertherapist.co.uk/body-image-training-with-harriet-frew.html

In this episode of Daily Value, we look at newer research on melatonin that challenges conventional wisdom. A recent meta‐analysis questions current clinical guidelines on melatonin use for sleep, suggesting there may be a dual (Dose X Time effect) secret to optimizing its effects. We'll break down the scientific clues behind optimal dosing, timing, and formulation, leaving you to wonder if you've been taking melatonin all wrong.Discussion Points:The clinical recommendations for melatonin may be “off”.What a recent meta-analysis (PMID: 38888087) suggests as better dosing and timing of melatonin.Formulation differences between fast-acting and extended-release melatonin.Practical tips for tailoring melatonin to boost your sleep quality.https://pubmed.ncbi.nlm.nih.gov/38888087/ Support the show

Study identifies potential treatment strategy for high-threshold peanut allergy; Emblaveo approved for complicated intra-abdominal infections; new tablet formulation of Evrysdi; FDA fast tracks investigational agents for Alzheimer disease and cannabis use disorder.  

Interview with John S. Barbieri, MD, MBA, and Michelle Wong, PhD, authors of The Role of Formulation in Benzene Formation in Benzoyl Peroxide Products. Hosted by Adewole S. Adamson, MD. Related Content: The Role of Formulation in Benzene Formation in Benzoyl Peroxide Products

Interview with John S. Barbieri, MD, MBA, and Michelle Wong, PhD, authors of The Role of Formulation in Benzene Formation in Benzoyl Peroxide Products. Hosted by Adewole S. Adamson, MD. Related Content: The Role of Formulation in Benzene Formation in Benzoyl Peroxide Products

Karen’s ‘back to basics’ mini-series continues this week with part two, which takes a look at ‘Formulation’. Formulation is, as Karen says, “The reason you are here.” It is the very essence of perfume making, but it is also an area that most beginners rush into and, by doing so, make a number of costly, but easily avoidable, mistakes. In this episode, Karen breaks down the basics of formulation, guides you through the process of creating stunning formulas and goes into detail on the most common mistakes so that you can avoid them and formulate with ease. KEY TAKEAWAYS A mistake a lot of beginners make is to throw their favourite materials together and expect a beautiful-smelling scent. However, as Karen explains, without a complete understanding of what each material will bring to the party, this will inevitably end in disaster. Karen introduces the idea of scent mapping - a way to organise and guide your material selection. She discusses in detail how it works and how it can enable you to create solid formulations. Less is often more when it comes to formulation. Karen gives her advice on how to avoid a very costly mistake - using too many conflicting materials. What are the most common mistakes that beginners make when it comes to formulation? Karen goes over them in detail and gives you pointers on how to avoid them. BEST MOMENTS “There’s a temptation to throw together your favourite materials and hope that something magical will happen, but successful perfumes are not just about mixing materials that you love the smell of.” “As you get comfortable with formulation it is easy to fall into a few common traps. Knowing what to watch out for is going to save you time.” “Just because you’ve got something that smells great initially, doesn’t mean you have to stop. you can still tweak it.” EPISODE LINKS In Person Class Artisan Perfumery Mastermind VALUABLE RESOURCES Getting Started Guide Artisan Perfumery Mastermind ABOUT THE HOST Fragrance expert, author, teacher and speaker; Karen Gilbert runs courses in the UK and online which demystify the secretive world of perfumery in a fun and interactive way. Karen has inspired thousands of students to explore their olfactory sense and create their own personalised fragrances. With extensive product development experience in both the commercial perfumery and the organic skincare industry, Karen is able to offer a unique insight into creating natural and mixed media fragrances for fine fragrance, room scents and skincare/bodycare products using commercial perfumery techniques. Karen is also a certified meditation teacher and has a passion for helping people to create daily rituals that integrate scent with other modalities to shift state and increase your sense of wellbeing. CONTACT DETAILS Website Instagram Facebook YouTube Email

Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from February 1-7, 2025.

Click here to send me a quick message :) Midwinter can feel like such a draggy time characterized by cold days, lots of time inside, and often low mood and lack of inspiration - especially for people of the earth who love being outside with the plants! What are some ways you can bring the herbs into your winter routine? What if it can be simple?In this episode, I share how to incorporate herbs into teas, broths and tinctures -- both from a very simple intuitive, creative lens and also a more intentional, structured lens. It's easy to forget about how many herbs you may have access to already, some of which may even be in your spice cabinet already. If you're curious about some possible ways to practice herbalism in the winter, and start simple formulation for yourself and your family, this episode is perfect for you.Listen to learn:the keys to effective formulationhow to simply add herbs into your winter routinesome restorative tonic herbs to add to your brothsideas about getting to know herbs you already have access toResources:Today's shownotes: Midwinter herbalism - teas, broths, tincturesSign up for the Natural Contraception waitlistSacred Window Podcast (interview w me): Lost Art of Restorative TonicsEpisode 12: The simple + sacred practice of making teasEpisode 22: Stinging nettles herbal spotlightEpisode 82: How to make oxymels, vinegars + shrubsIf you loved this episode, share it with a friend, or take a screenshot and share on social media and tag me @herbalwombwisdomAnd if you love this podcast, leave a rating & write a review! It's really helpful to get the show to more amazing humans like you.  ❤️DISCLAIMER: This podcast is for educational purposes only, I am not providing any medical advice, I am not a medical practitioner, I'm an herbalist and in the US, there is no path to licensure for herbalists, so my role is as an herbal educator. Please do your own research and consult your healthcare provider for any personal concerns.Support the show

In this episode of "Product & Packaging Powerhouse," host Megan Young Gamble discusses 2025 trends and transitions in product development and packaging, especially in the beauty industry. Emphasizing hyper personalization and prejuvenation, Megan highlights how biotechnology and advanced technology are reshaping personalized beauty and skincare. She also stresses the importance of sustainability in packaging and product choices, with tips on how brands and consumers should approach it. She concludes with insights into her company GLC's new mission to become the  leading in beauty operations, accelerating prestige and sustainable products and packaging by the end of 2026.Affiliate & Other Links: [Megan Young Gamble Links][AFFILIATE] Ready to crank out your content in as little as 5 minutes? Use Castmagic, AI powered tool to take your content creation from overwhelmed to overjoyed by saving hours of developing content. Save 20 hours by Signing up today! https://get.castmagic.io/Megan [FREEBIE] Learn about “day in the life” of a Packaging Project Manager → Get our “Starter Packaging PM Freebie” [link] https://glc.ck.page/thestarterpackagingprojectmanager Subscribe & Access our Video Vault YouTube Channel [ link] https://bit.ly/GLConYouTubeJoin our Email List [link] https://glc.ck.page/55128ae04b Follow and Connect with Megan on LinkedIn [link] https://linkedin.com/in/megangambleLearn about GLC, Packaging & Project execution firm for CPG brands http://www.getlevelconsulting.comWork with Me @ GLC, Schedule Discovery Call https://calendly.com/getlevelconsulting/15-minute-insight-sessionGot a topic you'd love us to cover? Share your ideas here [link] https://bit.ly/ppptopicformAdditional Resources:Podcast : Kickoff 2025 Trends & Transitions Pt 1 with Megan Young Gamble, PMP®, Chief Project Officer @ GLC. Listen it hereUS Plastic Pact 2.0. Read here Report: Sustainable Beauty and Skincare Market Size. hereEpisode Quotes:Change doesn't come by being comfortable. Big audacious goals require stepping out of comfort zonesPackaging is the very first impression of your brand. It helps with transportation, containment, safety, and promotion.Hyper personalization is about tailoring products specifically to the consumer's needs, made possible by advancements in AI and biotechnologyPrejuvenation focuses on preventing skin damage before it happens, shifting the mindset from repair to proactive care.Sustainability is not just a buzzword. It's about understanding what it means to your brand and your consumers.Biotechnology is marrying science and sustainability, creating lab-grown ingredients like collagen and plant-derived activesConsumers are prioritizing products with holistic wellness benefits, focusing on longevity and gradual results rather than quick fixes.

Check out our recap and breakdown of Season 4 Episode 6 of the Big Bang Theory! We found 6 IQ Points!00:00:00 - Intro00:11:57 - Recap Begins00:14:28 - The biggest car company in India00:22:11 - Train(ing) Day! Carney's and Travel Town breakdown00:43:42 - Bifurcated uvulas and then some! 00:58:49 - Lucky Baldwins01:13:32 - Caprica 01:21:22 - Allowable amount of insects in your foodFind us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) Music by Alex Grohl. Find official podcast on Apple and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

When you think of UTI and herbs, you probably think of cranberry and uva ursi first. You're not wrong to do so! They're reliable and effective remedies. But if you stop there, though, you'll be missing out on some herbs who can also do the job, and do it well. In this episode we outline two herbal UTI formulae we work with ourselves, and explain why and how they're helpful.We also take this opportunity to demonstrate our method of formulation, and show how the same actions and qualities can be achieved from different sets of plants.Formula 1:primary – yarrow (Achillea millefolium) flower, goldenrod (Solidago spp.) flower;support – linden (Tilia spp.), marshmallow (Althaea off.) leaf, chamomile (Matricaria recutita)catalyst – juniper (Juniperus spp.)Formula 2:primary – heather (Calluna vulgaris), calendula (Calendula off.)support – marshmallow (Althaea off.) root, catnip (Nepeta cataria), fennel (Foeniculum vulgare)catalyst – cedar (Thuja plicata) leafIf you'd like to learn more about supporting your urinary system, our Urinary Health course is for you! It's too common to neglect this system of the body – until something goes wrong. Take proactive steps to prevent UTIs and kidney stones, and learn methods to manage issues such as interstitial cystitis or incontinence. You'll be glad you did!And if you'd like to dig deeper into formulation, well, then our Fundamentals of Formulation course is where to go next! Learn our strategies for combining herbal actions and balancing the qualities of herbs to produce more effective remedies.Like all our offerings, these are self-paced online video courses, which come with free access to twice-weekly live Q&A sessions with us, lifetime access to current & future course material, open discussion threads integrated in each lesson, an active student community, study guides, quizzes & capstone assignments, and more!If you enjoyed the episode, it helps us a lot if you subscribe, rate, & review our podcast wherever you listen. This helps others find us more easily. Thank you!Our theme music is “Wings” by Nicolai Heidlas.Support the showYou can find all of our online herbalism courses at online.commonwealthherbs.com!

Send us a textThis episode features Grant Light, Josh Blum and John Vance.We want your helmet (for the AVB CTC)! Check this out to find out more: https://www.youtube.com/watch?v=Qg5_ZwoCZo0Sign up for the B Shifter Buckslip, our free weekly newsletter here: https://lp.constantcontactpages.com/su/fmgs92N/BuckslipShop B Shifter here: https://bshifter.myshopify.comAll of our links here: https://linktr.ee/BShifterPlease subscribe and share. Thank you for listening!This episode was recorded on January 16, 2025.A technical rescue operation at a Duke Energy smokestack highlights the critical importance of communication, teamwork, and planning in emergency situations. The coordinated efforts of multiple teams allowed for the safe extraction of a worker trapped 150 feet in the air.• Overview of the emergency call and initial fire department response • Assessment of the worker's situation and elevator stability • Communication with technical experts for real-time updates • Formulation of a rescue strategy with a focus on safety • Use of crane technology over alternative rope rescue methods • Successful communication between rescue teams on-site • Post-incident debriefing to assess response and identify lessons learned • Importance of training and understanding equipment in rescue scenarios

Show Notes: In this episode of Unleashed, Will Bachman interviews Bart Sayer, an expert on the beauty industry. Bart worked for nine years at the Estée Lauder Companies, most recently as the International General Manager for one of its largest brands, Clinique, managing the $1B P&L. Previously, Bart was a partner at Booz & Company (now Strategy&, part of PwC), focused on strategy and commercial transformation in the Consumer & Retail sectors. The conversation focuses on understanding the structure of the beauty market and the main drivers of value creation.   The Beauty Industry Explained Bart explains that the beauty industry is divided into four main categories: skincare, makeup, hair, care, and body. The market is divided into luxury and mass segments, with luxury beauty expected to grow between six and 8% in the foreseeable future. Taking the example of the United States, mass brands are more likely to be found in drugstores, such as Walgreens and CVs. Premium brands are more available in department stores or specialty multi, such as Sephora and Ulta, and a third channel being direct to consumer. At Estee Lauder they believed that distribution defines your equity, so prestige brands are careful about where they appear, hence the careful consideration and strict conditions associated with entering a channel like Amazon. Looking beyond the NA market, Travel Retail has been an important growth vehicle for luxury beauty brands over the past decade, though this growth has tempered in the past few years. Future growth of the beauty industry will remain defined by its two largest markets, the United States and China, while up-and-coming middle market countries will also represent attractive opportunities (e.g., India, Mexico, Brazil).   Manufacturing, Testing and Ingredients The ingredients in mass and prestige products can differ in terms of the scarcity or rarity of the actives, including use of proprietary ingredients and formulations. Formulation philosophies vary widely across different entities. Many brands, for example, put extra protections in place to ensure product safety for sensitive skin and/or to conduct rigorous allergy testing. Bart discusses the importance of clinical testing in product and research development, highlighting that it is a high barrier to entry for indie brands. He also discusses the evolution of more nimble production models, including the prevalence of contract manufacturers that can manufacture the latest ingredients and bespoke formulations in quicker and more cost-effective ways than many of the brands themselves. This approach is not binary, as L'Oreal has over 40 different manufacturing facilities worldwide. Before leaving the manufacturing discussion, Bart quickly hit upon another topic, that of the evolution to more earned media-led marketing models, whereby companies seize organic market buzz before amplifying these messages with paid media. Local vs. Global Adaptation The concept of local versus global adaptation is crucial in the beauty industry. Brands must find a locally relevant articulation of their brand essence. Large media companies often have global ambassadors who can speak for the brand, but if a local face is not available, the brand may not get the traction needed. To succeed, brands must be more reactive to local market trends, deploying local influencers, tailored messaging and selecting locally relevant forums for generating PR, both online and offline.   Indie and Newer Brands The conversation turned to the shift towards indie and newer brands in the beauty retail industry. The reasons behind the growth of the indies include lower barriers to entry on social media channels, an agile marketing model, the wide availability of contract manufacturers, and channel partners like Sephora that are focused on curating exclusive collections of the next “it” beauty brands. Often for these indie brands, the problem is not the launch itself (recruitment), but the stickiness (retention). Many of these companies struggle with repeat purchases, which are the key to success.   Sales and Distribution in the Beauty Industry Bart discussed several high growth channels, including Sephora, a leading premium beauty retailer owned by the LVMH group, travel retailer and beauty e-tailers such as Zalando and Notino. Traditional points of distribution, such as department stores and perfumeries, have seen slower growth, especially in the West (and far less so in the East). Whatever the channel, the importance of constructing good “self-navigating experience” for prestige consumers is key. Across many of these newer retailers, clean beauty is a key theme, as is green and sustainable, free of parabens, sulfates, certain ingredients and fragrances. This raises the bar for brands to prove their bona fides in terms of ingredient publishing and sourcing. The conversation then pivoted to challenges in the supply chain, including shelf life of products (especially for consumers in the East) and SKU proliferation.   Demand Forecasting Robust demand forecasting is crucial for brands to succeed to avoid out-of-stock situations and, conversely, the proliferation of excess. This can be particularly problematic when trying to create buzz and excitement with limited edition collections such as those sold over the holidays. Given profit, brand equity and sustainability concerns, rands have increasingly tried to err on the side of caution in their forecasts (FOMO). SKU periphery proliferation is another issue that brands are constantly fighting, seeking a balance between getting new out there while staying consistent and building out their portfolio. Store Design and Staffing Models In department stores, cosmetics brands often have significant control over the design of their stores, including all signage, key visuals and other elements of visual merchandising (e.g., gondola design, planogram setup). Done correctly, these can be huge differentiators. Unsurprisingly, prestige beauty brands have armies of store design, visual merchandising and staff (beauty advisor) education teams. Cost sharing with retail partners – CAPEX, staffing, promo – vary by channel and partner, thus representing a critical point in commercial negotiations (along with other topics like trade margin).   The Lucrative Nature of the Beauty Industry  The cosmetics industry is a highly lucrative business with operating profits ranging from 10 to 25%. Gross margins can be 65% or more, depending on the brand and the type of product. Highest gross margin categories include skincare and luxury fragrances. However, there is no room for complacency, with many waging a constant war to lower the cost of goods through a combination of gross to net improvements, price increases, mix optimization, promo efficiencies and, of course, manufacturing savings. A hero-product focus is needed to get scale, thus providing ballast for marketing investments. Premiumization trade trends are continuing across categories and subcategories, with no sign of these trends abating.  Timestamps: 03:30: Structure of the Cosmetics Industry and Market Segments 05:26: Specialty Channels and Distribution Strategies  07:58: Differences Between Mass and Prestige Brands 10:06: Analyzing the Cosmetics Industry: Product and Research Development  13:44: Marketing and Consumer Insights 18:33: Sales and Distribution Channels 22:49: Operations and Supply Chain  31:57: Gross Margin Analysis and Financial Performance  Website Links: #1, Beauty Market Outlook: https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/the-beauty-boom-and-beyond-can-the-industry-maintain-its-growth #2, FDA Regulations of Cosmetics: https://www.fda.gov/cosmetics/cosmetics-science-research/product-testing-cosmetics #3, Risk of Indie Beauty Brands: https://cosmeticsbusiness.com/how-indie-beauty-brands-can-break-america#:~:text=Indie%20brands%20are%20greatly%20influencing,and%20most%20likely%20through%202025. #4, Beauty and Travel Retail: https://wwd.com/beauty-industry-news/beauty-features/tackling-beautys-travel-retail-conundrum-estee-lauder-loreal-clarins-bulgari-dfs-heinemann-1236682262/ #5, Green Beauty: https://www.forbes.com/sites/meimeifox/2023/12/22/green-glamour-12-clean-beauty-brands-leading-the-eco-revolution/ #6, Beauty & Supply Chain Challenges: https://www.voguebusiness.com/beauty/new-ingredients-higher-prices-reformulating-beauty-in-the-supply-crisis #7, QVC and Beauty: https://entm.ag/1wEfOci #8, Love, Indus (company referenced by Will and I during the discussion): https://loveindus.com/collections/shop?gad_source=1&gclid=Cj0KCQiAkJO8BhCGARIsAMkswyiVNdA36DRltbku4DqHeLj-dAbZxAfsVOWmkyEP6Ah9bsxaNi3L4g4aAqP4EALw_wcB Unleashed is produced by Umbrex, which has a mission of connecting independent management consultants with one another, creating opportunities for members to meet, build relationships, and share lessons learned. Learn more at www.umbrex.com.

In this episode, we sit down with Juraj Kocar, the CEO of Wyse Earth, to discuss his mission to provide natural support through adaptogenic honey. He dives into the world of adaptogens, particularly focusing on the powerful health benefits of adaptogenic mushrooms like reishi, cordyceps and lions mane. We explore the science behind these mushrooms, their ability to modulate the immune system, fight inflammation, and promote overall wellness. If you're curious about the intersection of nature and wellness, this episode offers valuable information on how this adaptogenic mushroom honey elixir is revolutionizing the way we think about vibrant health and resilience.Juraj Kocar, a 3x founder, is passionate about building and growing projects with meaning that impact the health & wellness of people worldwide. Currently, he's the CEO of Wyse Earth and on a mission to provide natural support via adaptogenic honey for the No. 1 health issue in the U.S.: chronic inflammation. As the CEO of Attune Health and Somavedic Technologies, he leads the strategic business and relationship development of two innovative ventures. Building on these experiences, he launched Wyse Earth to address chronic inflammation, the No. 1 health issue in the U.S., through powerful natural solutions. Wyse Earth focuses on adaptogenic products that harness high-potency adaptogenic extracts, combined with honey for enhanced taste and bioavailability. Guided by his knowledge of adaptogens—substances that increase the body's resilience to stress and restore balance—Wyse Earth's products feature adaptogenic mushrooms, some of the most effective natural agents against inflammation, to support holistic health and wellness.SHOW NOTES:0:40: Welcome to the show!1:15 About Wyse Earth3:47 Juraj Kocar's Bio4:13 Welcome him to the podcast!6:06 What are adaptogenic mushrooms?10:07 Signaling the immune system to work better12:02 Adaptogenic vs Psychedelic13:27 Formulation and dosage of Wyse Earth17:47 Quality & Sourcing of clean mushrooms19:00 Fruiting bodies vs Mycelium21:51 Raw vs heated honey22:31 Benefits of Reishi24:02 Benefits of Cordyceps25:55 *MAGNESIUM BREAKTHROUGH*27:52 Benefits of Lion Mane30:18 The story behind Wyse Earth31:08 *CAROL BIKE*33:14 The inspiration behind Wyse Earth38:19 Ketogenic diet, cancer, diabetes & honey46:10 Different blends of Wyse Earth40:55 Upcoming blend: Slim53:17 His finale piece of advice55:17 Where to find him57:13 Thanks for tuning in!RESOURCES:Wyse Earth - Discount code: BIOHACKERBABESIG: Wyse_EarthIG: Juraj.KocarBiOptimizer's Magnesium Breakthrough - code: biohackerbabes10Carol Bike - code: BIOHACKERBABES for $250 offSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

The conversation around hormone therapy for menopausal symptoms is pretty clear. Hormone therapy is the gold standard for treating hot flashes and night sweats and can help with many other common symptoms that come with the menopause transition. It's very effective and broadly safe. But recently, the conversation has evolved past symptom management and into preventative health with many experts suggesting that hormone therapy may play a larger role in extending a woman's healthspan, if not lifespan. That maybe we should all start taking hormones to protect our hearts and cognitive health. And there's promising research in those areas. Yet none of the medical associations recommend hormones for those purposes. Why? That's what we dig into this week with Professor Susan Davis, AO, who is a pioneer and leading expert in women's health as a clinical endocrinologist, researcher, and educator. She reflects on her decades of research on various forms of hormone therapy and shares what we know–and still don't know–today regarding traditional hormone therapy as well as testosterone therapy for women's health post menopause.Professor Susan R Davis AO, MBBS, FRACP, PhD, FAHMS is a clinician researcher with expertise in the role of sex hormones in women across the lifespan. She is Head of the Monash University Women's Health Research Program and holds a Level 3 NHMRC Investigator Grant. Susan is a Consultant Endocrinologist and Head of the Women's Endocrine Clinic, Alfred Hospital Melbourne and a consultant at Cabrini Medical Centre. She is a Fellow and Council Member of the Australian Academy of Health and Medical Sciences. She is a past President of the Australasian Menopause Society and the International Menopause Society. She has over 435 peer-reviewed publications and has received numerous national and international prestigious research awards. Susan was appointed an Officer of the Order of Australia for distinguished service to medicine, to women's health as a clinical endocrinologist and researcher, and to medical education. You can learn more about her and her work at Monash University.Resources2023 Practitioner's Toolkit for Managing Menopause hereMenopausal Hormone Therapy and Cardiovascular Disease: The Role of Formulation, Dose, and Route of Delivery hereUse of MHT in women with cardiovascular disease: a systematic review and meta-analysis hereStudying Studies: Part I – relative risk vs. absolute risk by Peter Attia, MD, hereJoin the Feisty Girona Gravel Camp: https://www.thomsonbiketours.com/trips/feisty-girona-gravel-camp/ Subscribe to the Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-page Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Lagoon Sleep: Go to LagoonSleep.com/hitplay and use the code HITPLAY to get $25 off any pillow between now and December 2, 2024. Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/ Nutrisense: Go to nutrisense.io/hitplay and book a call with a Registered Dietitian Previnex: Get 15% off your first order with code HITPLAY at...

Get my ebook and audiobook here: https://learntruehealth.com/op/addicted-to-wellness-ebook.   Get my course, The 7 Foundations of Health, here: https://learntruehealth.com/sp/7-foundations-of-optimal-health   Get a physical copy of my book here: https://learntruehealth.com/addictedtowellness.   The Vibe: https://learntruehealth.com/vibe coupon code LTH - LearnTrueHealth.com/vibe   Get the NEW free IIN sample class and health coach experience: https://learntruehealth.com/coach Enroll in the next Health Coach Training Program! Use coupon code LTH when signing up to become a health coach.   Dr. Ellen Kamhi PhD  RN AHN-BC RH(AHG) provides CE eligible certification educational modules in Herbal Medicine, Essential Oil Therapy, Homeopathy, Energy Medicine, and all aspects of holistic medicine, and supports individuals on their path to incorporate Herbal and Natural Therapies into their Life and Career. She is a respected Consultant in the Nutraceutical Industry providing Formulation, Education and Regulatory Review. Ellen  Kamhi is actively involved, along with Dr. Eugene Zampieron, ND, with Natural Alternatives Health, Education and Multimedia Services, and leads EcoTours For Cures™, which brings participants to indigenous areas to experience the ancient healing arts of traditional cultures. Dr.  Kamhi is available as a speaker and consultant.  for your organization.   For details, call (954) 418-2388 or http://www.naturalnurse.com/contact

Dr. Weiss and Dr. St-Pierre co-authored this episode's journal club paper in Applied Animal Science (ARPAS Journal). Bill and Normand share a career-long interest in how feedstuffs and diet variation impact cows. (6:31)Bill and Normand discuss sources of variation, which they divide into true variation and observer variation. True variation means the feed has changed: a different field, change during storage, etc. Observer variation includes sampling variation and analytical variation. Some feeds may exhibit a lot of true variation and others may exhibit a lot of observer variation. And some feeds are high in both types of variation. Highly variable feeds should be sampled more frequently. Some feeds are so consistent that using book values makes more sense than sending in samples for analysis. Bill and Normand go on to give some examples and share sampling and analysis tips for different types of feedstuffs. (12:41)Bill would often be asked if users should continue to average new samples with older ones or just use the new numbers from the most recent sample. He and Normand debate the pros and cons of the two approaches as well as discuss the use of a weighted average where recent samples would be weighted to contribute more. (26:02)Next, our guests discuss how multiple sources of a nutrient reduce the TMR variation for that specific nutrient. For example, alfalfa NDF is more variable than corn silage NDF on average. Yet if you use a blend of these two ingredients, you end up with less variation in NDF than if you used all corn silage. Normand details the mathematical concepts behind this relationship. Both Bill and Normand emphasize that diets must be made correctly for the best results. (32:26)How do feedstuffs and diet variations impact cows? Both guests describe different experiments with variable protein and NDF concentrations in diets. Some were structured, like alternating 11% CP one day and 19% CP the next for three weeks. Some were random, like randomly alternating the NDF over a range of 20-29% with much higher variation than we'd ever see on-farm. The common thread for all these experiments is that the diet variations had almost no impact on the milk production of the cows. (38:04)Clay asks how variation in dry matter might affect cows. Bill describes an experiment where the dry matter of silage was decreased by 10 units by adding water. Cows were fed the wet silage for three days, twice during a three-week study. To ensure feed was never limited, more as-fed feed was added when the wet silage was fed. It took a day for cows on the wet silage treatment to have the same dry matter intake (DMI) as the control cows and milk production dropped when DMI was lower. However, when switching abruptly back to the dry silage diet, DMI increased the day following the wet silage and stayed high for two days, so the cows made up for the lost milk production. Bill and Normand underline that it is critical for the cows not to run out of feed and described experiments where feed was more limiting, yielding less desirable outcomes. (46:17)In the last part of the paper, our guests outlined seven research questions that they feel need to be answered. Normand shares that his number one question is how long will cows take to respond to a change in the major nutrients? He feels that we spend an inordinate amount of money on feedstuffs analysis, and there are some feeds we should analyze more and some feeds we should quit analyzing. Bill's primary research question revolves around controlled variation. What happens if you change the ratio of corn silage and alfalfa once a week? Will that stimulate intake? Data from humans, pets, and zoo animals indicate that diet variation has a positive impact and Bill finds this area of research intriguing. (50:43)In closing, Clay encourages listeners to read this paper (link below) and emphasizes the take-home messages regarding sampling and research questions. Normand advises that if you are sampling feed, take a minimum of two samples, and try as much as you can to separate observer variation from true variation. He also reminds listeners to concentrate on a few critical nutrients with more repeatability for analyses. Bill encourages nutritionists to sit down and think when they get new data - before they go to their computer to make a diet change. If something changed, why did it change, and is it real? Take time to think it through. (1:01:38)You can find this episode's journal club paper from Applied Animal Science here: https://www.appliedanimalscience.org/article/S2590-2865(24)00093-4/fulltextPlease subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Cosmetic chemist AJ Addae is the founder of Sula Labs, a company that helps beauty brands develop and test products and ingredients for melanin-rich consumers. She's here to share her story and talk about the future of sunscreen and clean beauty, how bias affects scientific research, the difference between cosmetics and drugs, exosomes, vitamin C, why she loves sulfur for treating acne, brow lamination (aka, brow lammy), the best ingredients for edge control and brow grooming, her favorite products, and more. If you like Science Corner, you're going to love this interview with AJ!Episode recap with links: fatmascara.com/blog/aj-addaeProducts mentioned in this episode: shopmy.us/collections/1077600Sponsor links & discount codes: fatmascara.com/sponsorsPrivate Facebook Group: Fat Mascara Raising a WandTikTok & Instagram: @fatmascara, @jenn_edit, @jessicamatlin + contributors @garrettmunce, @missjuleeSubmit a "Raise A Wand" product recommendation: text us or leave a voicemail at 646-481-8182 or email info@fatmascara.com Become a member at https://plus.acast.com/s/fatmascara. Hosted on Acast. See acast.com/privacy for more information.

In this episode of the RWS Clinician's Corner, Margaret Floyd Barry meets with one of the world's top supplement formulators, Shawn Wells. Not only does Shawn give us the inside scoop on some really powerful new supplement ingredients and formulations, but he delves into the complex process of creating supplements, improving their bioavailability, and the science behind new, innovative ingredients on the market. We also explore the exciting world of exercise mimetics and their potential health benefits, especially for those unable to train due to severe health conditions. Plus, you'll hear about the exciting new ingredient, paraxanthine, and how it might soon revolutionize the market.  We discuss:   The supplement formulation process, with an emphasis on quality control and compliance How Shawn thinks about developing novel ingredients  Dihydroberine, L-ergothioneine & Spermidine: what they do and why they're important NAD and aging Benefits of Paraxanthine and Dileucine  Using Creatine for health (not just building muscle) - one of Shawn's top recommendations Blood sugar management with ​​Dihydroberine (vs. Metformin) Supplement integrity: key things to watch out for when researching a new product or line The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/ Timestamps:  00:00 Mother sold Shackley vitamins; early supplement industry. 06:21 Vitamin C research explores higher doses, benefits. 15:57 Paraxanthine benefits without caffeine's side effects. 20:23 Attention to detail signifies brand quality control. 27:31 Supplements: Can't claim cures, only support wellness. 29:04 High-earning products must be tailored to individuals. 35:04 Restorative Wellness Solutions: Transformative health practitioner training. 43:44 Mitochondrial health is crucial for combating aging. 48:07 NAD declines with age; polyphenols inhibit breakdown. 51:39 No caffeine side effects; boosts nitric oxide, dopamine. 59:44 Optimize leucine spikes for protein synthesis effectiveness. 01:01:53 Mitochondria abundance supports high energy cells. 01:06:51 Join, follow, share, suggest topics, change health. Speaker bio:  Shawn Wells MPH, LDN, RD, CISSN, FISSN is the world's leading nutritional biochemist and expert on health optimization. He has formulated over 700 supplements, food, beverages, and cosmeceuticals and patented 20 novel ingredients including Teacrine, Dynamine and Dihydroberberine and is now known as the “ingredientologist” - the scientist of ingredients.  Formerly a Chief Clinical Dietitian with over a decade of clinical experience, he has counseled thousands of people on innovative health solutions such as keto, paleo, fasting, and supplements. He has also personally overcome various health issues including Epstein-Barr Virus, Chronic Fatigue Syndrome, Fibromyalgia, depression, insomnia, obesity, and a pituitary tumor. As a world-renowned thought-leader on mitochondrial health, he has been paid to speak on five different continents. His insights have been prominently featured in documentaries and podcasts like Ben Greenfield and regularly on morning television. His expertise can help any health-conscious individual to better manage stress and experience greater resilience and more energy through utilizing his practical research-backed solutions. His book, The Energy Formula, has been recognized by both USA Today and Forbes as well as an Amazon best-seller in multiple categories.   Connect with Shawn Wells: Website: https://shawnwells.com/ Instagram: https://www.instagram.com/shawnwells/   And find his book, The Energy Formula, here. Keywords:  supplement formulation, Shawn Wells, dihydroberine, paraxanthine, bioavailability, pharmacokinetics, cognitive function, physiological benefits, metformin alternatives, CGMP certification, exercise mimetics, L-valine, Albeba, insulin sensitivity, mitochondrial health, longevity vitamins, L-ergothioneine, spermidine, anti-aging supplements, NAD levels, NMN vs NR, apigenin, fisetin, autoimmune diseases, gluten sensitivities, paresthesis, caffeine metabolites, dileucine, continuous glucose monitor, acetyl-L-carnitine, creatine Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Denial. Substance use. Venting. Positive reframing. Humor. Acceptance. All of these are ways we cope with stressful situations. Some we may consider healthy or unhealthy coping strategies, but are they really that easy to categorize? Isn't it more important to ask whether a particular coping behavior is adaptive or not for a particular person,in a particular time or situation? We are going to tackle this question and so many more about coping on this week's podcast with Dani Chammas, a recurring GeriPal guest, psychiatrist, and palliative care doc at UCSF, and Amanda Moment, a Palliative Care Social Worker at Brigham and Women's Cancer Center. There are so many take-home points for me on this podcast, including this one on a framework for assessing coping in serious illness: nonjudgmentally observe their coping wonder about the impacts of their coping prioritize helping patients maintain their psychological integrity mindfully think through how we can serve their coping in ways that they can tolerate, always calibrating based on the person, the moment, and the setting in front of us. Here are some more resources we've discussed in the podcast Dani's NEJM article on coping: “Should I Laugh at That? Coping in the Setting of Serious Illness” Dani's GeriPal podcast with us on “Improving Serious Illness Communication By Developing Formulations” A great journal article on “Formulation in Palliative Care: Elevating Our Potential for Therapeutic Communication” A study on how palliative care may work by enhancing patients' ability to access adaptive coping - “Role of Patient Coping Strategies in Understanding the Effects of Early Palliative Care on Quality of Life and Mood ** NOTE: To claim CME credit for this episode, click here **  

Dans cet épisode incontournable de Beauty Toaster, je lève le voile sur un scandale sanitaire majeur. Les produits lissants à l'acide glyoxylique, largement utilisés dans les salons de coiffure, menacent gravement la santé des reins. Insuffisances rénales aigües, avec à la clef, dialyse, voire greffe, les conséquences sont lourdes, et malgré les alertes de l'Académie Nationale de Médecine et de l'ANSES, ces produits dangereux sont toujours utilisés et en vente.Pour éclairer cette problématique de santé publique, j'ai invité les Prs Thomas Robert et Emmanuel Letavernier, néphrologues reconnus, qui confirment sans détour la dangerosité de l'acide glyoxylique. Les tests effectués par le Pr Letavernier sont formels et glaçants : l'usage de ces produits peut condamner à des soins médicaux lourds pour la vie.Écoutez cet épisode et partagez-le largement ! Informez vos proches, vos amis, vos coiffeurs et surtout les personnes qui envisagent de faire un lissage. Il y va de leur santé, de leurs reins, de leur avenir. Ce n'est pas d'une allergie dont il s'agit, mais d'un risque de maladie rénale sévère et irréversible.Retrouvez Beauty Toaster sur Apple Podcast, Spotify, Deezer, YouTube et toutes vos plateformes de podcasts préférées. Pensez à laisser un avis et 5 étoiles pour aider à faire connaître ce podcast à d'autres auditeurs.Merci pour votre écoute, votre fidélité et votre soutien. Ensemble, faisons de Beauty Toaster la voix de la prévention et de l'information santé dans le monde de la beauté.

Épisode 246. À l'heure où tous les parfums mainstream sentent le bonbec ou la barbe à papa jusqu'à l'écoeurement, ça bouge dans la parfumerie. Le parfum se réinvente. Imaginez un jus qui augmenterait votre moral ou encore votre concentration. C'est ce que propose Pascale Fontaine, la fondatrice d'Amoi Parfums qui a lancé quatre fragrances qu'elle qualifie de boosters d'émotions.Comment est-ce que cela fonctionne ? Et surtout, peut-on aujourd'hui mesurer scientifiquement les effets de ces notes sur le cerveau ? La réponse est OUI !Passionnée de parfums et de neurosciences, Pascale nous explique son processus créatif et l'étude qu'elle a mise en place pour prouver ses allégations.Allez, à vos écouteurs, c'est l'heure de Beauty Toaster.Si vous avez cet épisode, abonnez-vous (c'est gratuit !) sur Apple Podcast, Spotify, Deezer ou encore Youtube et sur toutes les bonnes plateformes de podcasts. Et laissez un commentaire et plein d'étoiles sur Apple Podcast et Spotify. Vous permettrez à d'autres auditeurs de découvrir Beauty Toaster. Enfin, parlez-en beaucoup autour de vous. Partagez vos découvertes avec votre famille, vos ami(e)s, et tous les passionné.es de beauté que vous connaissez, même s'ils vivent loin de vous ;-). Beauty Toaster s'écoute partout dans le monde. Merci infiniment pour votre écoute, votre fidélité et votre soutien.

In this episode I interview George Murray. He went to college at Purdue where he studied plant physiology and plant metabolomics. He now works in the fertilizer industry and is the formulation chemist for Ventana Plant Science and Stash Blend. In this episode he talks about several organic inputs, their benefits, sourcing, bacteria, fungi, and more.Wild Times: Wildlife EducationWildlife mysteries, crazy news, and daring animal stories—listen now!Listen on: Apple Podcasts SpotifySupport the show

In this episode of Skincare Anarchy, Dr. Ekta Yadav dives into the fascinating world of cosmetic chemistry with industry expert Kelly Dobos. With 25 years of experience and a role as an Adjunct Professor of Cosmetic Science, Kelly shares her deep knowledge of skincare and cosmetic formulations, offering listeners a rare glimpse into the science behind the beauty products they use daily.Kelly's journey into cosmetic chemistry began with a passion for understanding how things work on a molecular level. From her early days as a lab assistant to becoming a leading figure in the field, Kelly's expertise has shaped her approach to developing innovative and effective beauty products. She emphasizes the importance of understanding the complex interplay of ingredients in formulations, from the foundational components that hydrate and protect the skin to the cutting-edge biotechnology that's driving the future of the industry.Throughout the episode, Kelly discusses the challenges of creating stable, safe, and effective products, particularly when dealing with active ingredients like vitamin C. She also addresses the misconceptions surrounding preservatives in the clean beauty movement, advocating for science-based decision-making in product development.Kelly's insights are not only informative for beauty enthusiasts but also inspiring for those considering a career in cosmetic chemistry. Her dedication to science and innovation underscores the critical role that cosmetic chemists play in shaping the future of beauty.Tune in to hear more from Kelly Dobos and explore the science that makes your favorite beauty products possible. To learn more about Kelly Dobos and her work in cosmetic chemistry, you can follow her on LinkedIn or explore the courses available at the University of Cincinnati's Master's program in Cosmetic Science. Don't forget to subscribe to Skincare Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions. Hosted on Acast. See acast.com/privacy for more information.