Podcasts about epigenomics

Wspierają, goją, karmią, bronią, asystują. Czym są astrocyty – milczący bohaterowie drugiego planu, bez których funkcjonowanie neuronów byłoby niemożliwe? Rozmowa z badaczką tych niezwykłych komórek, dr hab. Aleksandrą Pękowską, profesorką Instytutu Biologii Doświadczalnej im. Marcelego Nenckiego PAN, kierowniczką Dioscuri Centre for Chromatin Biology and Epigenomics.

Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology. He works in computational biology, taking giant datasets relating to genetics and health outcomes and tries to understand what's going on. Manolis' research focuses on genomics, and a related field called epigenomics. Manolis' problem is this: What are the cellular mechanisms of a disease? And how can we intervene to keep people healthy?See omnystudio.com/listener for privacy information.

Explore the realm of epigenomics through the insights of Dr. Stefano Bini's interview with Madalena Adorno, CEO of Dorian Therapeutics. Uncover Adorno's pioneering research on stem cells and aging biology, shedding light on the intricate interplay between senescent and stem cells in the context of aging and conditions like osteoarthritis. She also delves into her breakthrough studies on Down syndrome, revealing the identification of a key gene driving the aging phenotype.Tune in to learn how Dorian Therapeutics is pioneering a small molecule approach to USP 16 inhibition, offering promising avenues in the field of aging research.

References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.01.538832v1?rss=1 Authors: Zhou, J., Zhang, Z., Wu, M., Liu, H., Pang, Y., Bartlett, A., Rivkin, A. C., Lagos, W. N., Williams, E., Lee, C.-T., Miyazaki, P. A., Aldridge, A. I., Zeng, Q., Salinda, J. L. A., Claffey, N., Liem, M., Fitzpatrick, C., Boggeman, L., Yao, Z., Smith, K. A., Tasic, B., Altshul, J., Kenworthy, M. A., Valadon, C., Nery, J. R., Castanon, R. G., Patne, N. S., Vu, M., Rashid, M., Jacobs, M. W., Ito-Cole, T., Osteen, J., Emerson, N., Lee, J., Cho, S., Rink, J., Huang, H.-H., Pinto-Duartec, A., Dominguez, B., Smith, J. B., O'Connor, C., Zeng, H., Lee, K.-F., Mukamel, E. A., Jin, X., Behrens, M. M., Eck Abstract: Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

References Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front.Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In der heutigen Folge „Alles auf Aktien“ sprechen die Finanzjournalisten Nando Sommerfeldt und Holger Zschäpitz über die neue Biontech-Realität, ein mittelschweres Krypto-Beben und die E-Auto-Aktie mit dem zweiten Leben. Außerdem geht es um First Citizen Bank, First Republic, Deutsche Bank, Commerzbank, Novartis, Carnival, Porsche, Neste, Siemens Energy, Coinbase, Epigenomics, Paion, Accento Real Estate, Delivery Hero, Mr Spex, Energiekontor, Mutares, Vonovia, United Internet, MLP, Cropenergies, PNE Wind, SFC Energy, Deutsche Bank, VW, 7c Solarparken, Hypoport, Ionos, Knaus Tabbert, Baywa, Sixt, Fisker, Mercedes-Benz, BMW, Tesla.  Wir freuen uns an Feedback über aaa@welt.de. Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

Editor's Note: Theral's mic malfunctioned in this interview. Fortunately the not as good backup mic did work and John has a good mic.  Our apologies. John Greally joins us today. He is the founding Director of the Albert Einstein College of Medicine's Center for Epigenomics. He's a pediatrician and a clinical geneticist with appointments in both at Einstein.

We understand that childhood obesity isn't something that can be solved (or even explained) in one hour, but we scratch the surface with fellow registered dietitian, Deirdre Pizzoferrato, about what are some possibilities for the root causes and what are some of the preventative measures we can take to help shift the numbers in a positive direction. Today, we unpack: What are some of the root causes of childhood obesity? How much does our genetics and epigenomics play a role? What is the primary prevention? Can nutrition during pregnancy impact the child's metabolism? How do these factors this impact the microbiome? How does this tie back into the gut-brain relationship? What are the different methods to childhood feeding? Let's get into it!  Want to take a look at some of the resources that Deirdre has to offer? Let us hook you up! You can find her on her website, read her book, and take a look at some of her many resources. Prefer to watch instead of listen? We love to put a face to the name, and Addie's is one to recognize.  You can see our livestreamed chat on our YouTube channel! Did we tell you that we have this awesome membership available? We have launched all THREE PHASES Lean for Life Membership called Heal, Optimize , and Refine where you will be empowered to reverse previous metabolic damage with the assistance of our team of Registered Dietitian Nutritionists. Check out more details on our website! Want to learn more about our one-on-one Empowered Nutrition coaching? Book a free chemistry call to discuss your story and see if we're a good fit. Enjoying the podcast? Please review the Empowered Nutrition Podcast on Apple Podcasts or wherever you listen! Then, send me a screenshot of your positive review to podcast@empowerednutrition.health as a DM on Instagram (empowerednutrition.health). Include a brief description of what you're working on with your health and/or nutrition and I'll send you a free custom meal plan! Do you have questions you would like answered on the Empowered Nutrition podcast? You can propose your questions/ideas here or reach out to me at podcast@empowerednutrition.health

Understanding how genes function is a vital part of understanding how to better treat cancer. Research led by Mazhar Adli, PhD, is grounded in the development of a systematic approach to identify the function of each gene in the human body. His team aims to discover novel therapeutic drug combinations to prevent cancer development and chemotherapy resistance. 

Guest:   Alexandre Gaspar Maia, Ph.D. (@gasparma1a) Host: Denise M. Dupras, M.D., Ph.D. Epigenomics is a fascinating field in which researchers chart the locations and understand the functions of all chemical tags that mark the genome. The epigenome is the first boundary from the exterior world to our DNA sequence, and it can change dramatically. This episode discusses the state of the art of epigenomics analysis and the epigenome in the context of specific cells. Additionally, it explores the future of epigenomics for individualized medicine and in better understanding genetics of treatment resistance. The guest for this episode is Alexandre Gaspar Maia, Ph.D., an assistant professor in the Functional Genomics Laboratory at Mayo Clinic. Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

In this episode of the Epigenetics Podcast, we caught up with Tim Petros from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the NIH to talk about his work on Single Cell Epigenomics in Neuronal Development.  The Petros lab focuses on “interneurons”, their diversity and how environmental signals interact to generate this diversity. This subgroup of neurons comprise about 20% of neutrons in the brain, however, they are the primary source of inhibition. Furthermore, interneurons are critical components in modulating information flow throughout the nervous system. The Petros lab seeks to uncover the genetic programs that lead to the incredible diversity in interneurons, as well as how the local environment influences this process.  To lay a foundation for this and to provide a data-base for other researchers the Petros lab generated an epigenome atlas of neural progenitor cells of the mouse brain. This data includes scRNA-Seq, snATAC-Seq, CUT&Tag (H3K4me3, H3K27me3), CUT&RUN (H3K27ac), Hi-C and Capture-C. This data can be downloaded at the link below:   https://www.nichd.nih.gov/research/atNICHD/Investigators/petros/data-sharing    References Datasets: https://www.nichd.nih.gov/research/atNICHD/Investigators/petros/data-sharing Quattrocolo G, Fishell G, Petros TJ. Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation. Cell Rep. 2017 Oct 17;21(3):721-731. doi: 10.1016/j.celrep.2017.09.075. PMID: 29045839; PMCID: PMC5662128. Dongjin R Lee, Christopher Rhodes, Apratim Mitra, Yajun Zhang, Dragan Maric, Ryan K Dale, Timothy J Petros (2022) Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain eLife 11:e71864 https://doi.org/10.7554/eLife.71864 Rhodes, C. T., Thompson, J. J., Mitra, A., Asokumar, D., Lee, D. R., Lee, D. J., Zhang, Y., Jason, E., Dale, R. K., Rocha, P. P., & Petros, T. J. (2022). An epigenome atlas of neural progenitors within the embryonic mouse forebrain. Nature communications, 13(1), 4196. https://doi.org/10.1038/s41467-022-31793-4   Related Episodes The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze) Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics) The Role of DNA Methylation in Epilepsy (Katja Kobow)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

A few weeks ago Katie covered a mini episode on Families & Intergenerational Trauma after a recent trip to see her family. While Katie covered a lot of detail on personal experience, on PTSD, and therapy, Ashleigh is leading this week's episode and doing a call back specifically on Epigenetics and inherited traits. Ashleigh utilizes her knowledge as a Genetic Counselor to lead this conversation. Join in and learn more!References:The Weekend University PodcastMcCartney DL, Stevenson AJ, Hillary RF, Walker RM, Bermingham ML, Morris SW, Clarke TK, Campbell A, Murray AD, Whalley HC, Porteous DJ, Visscher PM, McIntosh AM, Evans KL, Deary IJ, Marioni RE. Epigenetic signatures of starting and stopping smoking. EBioMedicine. 2018 Nov;37:214-220. doi: 10.1016/j.ebiom.2018.10.051. Epub 2018 Oct 30. PMID: 30389506; PMCID: PMC6286188.Yehuda R, Lehrner A. Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms. World Psychiatry. 2018 Oct;17(3):243-257. doi: 10.1002/wps.20568. PMID: 30192087; PMCID: PMC6127768.Alegría-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics. 2011 Jun;3(3):267-77. doi: 10.2217/epi.11.22. PMID: 22122337; PMCID: PMC3752894.Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009 Dec;12(12):1559-66. doi: 10.1038/nn.2436. Epub 2009 Nov 8. Erratum in: Nat Neurosci. 2010 May;13(5):649. PMID: 19898468.Szyf M, McGowan P, Meaney MJ. The social environment and the epigenome. Environ Mol Mutagen. 2008 Jan;49(1):46-60. doi: 10.1002/em.20357. PMID: 18095330.Richetto J, Meyer U. Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability. Biol Psychiatry. 2021 Feb 1;89(3):215-226. doi: 10.1016/j.biopsych.2020.03.008. Epub 2020 Mar 28. PMID: 32381277.Kellermann NP. Epigenetic transmission of Holocaust trauma: can nightmares be inherited? Isr J Psychiatry Relat Sci. 2013;50(1):33-9. PMID: 24029109.Jahan N, Went TR, Sultan W, Sapkota A, Khurshid H, Qureshi IA, Alfonso M. Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review. Cureus. 2021 Aug 17;13(8):e17251. doi: 10.7759/cureus.17251. PMID: 34540477; PMCID: PMC8448270.Monk D, Mackay DJG, Eggermann T, Maher ER, Riccio A. Genomic imprinting disorders: lessons on how genome, epigenome and environment interact. Nat Rev Genet. 2019 Apr;20(4):235-248. doi: 10.1038/s41576-018-0092-0. PMID: 30647469.McEwen BS, Bulloch K. Epigenetic impact of the social and physical environment on brain and body. Metabolism. 2019 Nov;100S:153941. doi: 10.1016/j.metabol.2019.07.005. PMID: 31610853.Cao-Lei L, de Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M. Prenatal stress and epigenetics. Neurosci Biobehav Rev. 2020 Oct;117:198-210. doi: 10.1016/j.neubiorev.2017.05.016. Epub 2017 May 18. PMID: 28528960.Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12. PMID: 26410355.Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004 Nov;49(11):726-35. doi: 10.1177/070674370404901103. PMID: 15633850. Hosted on Acast. See acast.com/privacy for more information.

In der heutigen Folge „Alles auf Aktien“ sprechen die Finanzjournalisten Nando Sommerfeldt und Philipp Vetter über durch Porsche geschürte Elektro-Fantasie, Airpod-Gerüchte bei Apple und einen schon totgeglaubten Konzern vor, der sich gerade neu erfindet. Außerdem geht es um Tesla, Poly.N, HP, Quantumscape, Westwing, Epigenomics, Windeln.de, Bet-at-home.com, 4SC,, Adler Group, Paragon, Medigene, Biofrontera, Multitude, Leoni, Morphosys, ThyssenKrupp, Lufthansa, Bayer, Continental, Teles, Beate Uhse. Wir freuen uns an Feedback über aaa@welt.de. Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Hörtipps: Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. Außerdem bei WELT: Im werktäglichen Podcast „Kick-off Politik - Das bringt der Tag“ geben wir Ihnen im Gespräch mit WELT-Experten die wichtigsten Hintergrundinformationen zu einem politischen Top-Thema des Tages. Mehr auf welt.de/kickoff und überall, wo es Podcasts gibt. +++Werbung+++ Hier geht's zur App: Scalable Capital ist der Broker mit Flatrate. Unbegrenzt Aktien traden und alle ETFs kostenlos besparen – für nur 2,99 € im Monat, ohne weitere Kosten. Und jetzt ab aufs Parkett, die Scalable App downloaden und loslegen. Hier geht's zur App: https://bit.ly/3abrHQm Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

Cancers are diverse and adaptable. That is why a staggering 97% of cancer drugs in clinical trials fail to receive FDA approval. Researchers try to stay one step ahead of cancer by studying the mechanisms that lead to drug resistance, finding new drug targets, and developing novel therapies, such as immunotherapeutics. In this episode narrated by Niki Spahich, Sejal Davla from The Scientist's Creative Services team spoke with Jason Sheltzer, an assistant professor in the Department of Genomics, Genetics, and Epigenomics and Yale Cancer Center at the Yale School of Medicine, about his work on drug resistance in cancer, chromosomal instability in cancer cells, and approaches to identify new treatment strategies.   The Scientist Speaks is a podcast produced by The Scientist's Creative Services team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research.

Dr. Guerra continues a dialectical accounting of the biochemical and cellular events leading to the terminal outcome of aging. Topic today is the reintroduction of Natural Killer Cells and the epigenetic mechanisms that orchestrate unique gene expression. References Anal Cell Pathol (Amst). 2018; 2018: 787.1814. The Journal of Biological Chemistry2018. 293: 2422-2437 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Im Marktgespräch am 20. Oktober 2020 ist der Kursabschwung nach dem kurzen Erreichen der 13.000 im DAX gestern noch einmal Thema. Welche Unsicherheitsfaktoren belasten die Börse aktuell? Zudem schauen wir uns die Kursbewegungen bei Epigenomics, IBM und BMW an.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.13.338004v1?rss=1 Authors: Feng, F., Yao, Y., Wang, X. Q. D., Zhang, X., Liu, J. Abstract: The resolution of chromatin conformation capture technologies keeps increasing, and the recent nucleosome resolution chromatin contact maps allow us to explore how fine-scale 3D chromatin organization is related to epigenomic states in human cells. Using publicly available Micro-C datasets, we have developed a deep learning model, CAESAR, to learn a mapping function from epigenomic features to 3D chromatin organization. The model accurately predicts fine-scale structures, such as short-range chromatin loops and stripes, that Hi-C fails to detect. With existing epigenomic datasets from ENCODE and Roadmap Epigenomics Project, we successfully imputed high-resolution 3D chromatin contact maps for 91 human tissues and cell lines. In the imputed high-resolution contact maps, we identified the spatial interactions between genes and their experimentally validated regulatory elements, demonstrating CAESAR's potential in coupling transcriptional regulation with 3D chromatin organization at high resolution. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.279554v1?rss=1 Authors: Liu, N., Sadlon, T., Wong, Y. Y., Pederson, S. M., Breen, J., Barry, S. C. Abstract: Background: Genome-wide association and fine-mapping studies have enabled the discovery of single nucleotide polymorphisms (SNPs) and other variants that are significantly associated with many autoimmune diseases including type 1 diabetes (T1D). However, many of the SNPs lie in non-coding regions, limiting the identification of mechanisms that contribute to autoimmune disease progression. Methods: Autoimmunity results from a failure of immune tolerance, suggesting that regulatory T cells (Treg) are likely a significant point of impact for this genetic risk, as Treg are critical for immune tolerance. Focusing on T1D as a model of defective function of Treg in autoimmunity, we designed a SNPs filtering workflow called 3 Dimensional Functional Annotation of Accessible Cell Type Specific SNPs (3DFAACTS-SNP) that utilises overlapping profiles of Treg-specific epigenomic data (ATAC-seq, Hi-C and FOXP3-ChIP) to identify regulatory elements potentially driving the effect of variants associated with T1D, and the gene(s) that they control. Results: Using 3DFAACTS-SNP we identified 36 SNPs with plausible Treg-specific mechanisms of action contributing to T1D from 1,228 T1D fine-mapped variants, identifying 119 novel interacting regions resulting in the identification of 51 candidate target genes. We further demonstrated the utility of the workflow by applying it to three other fine-mapped/meta-analysed SNP autoimmune datasets, identifying 17 Treg-centric candidate variants and 35 interacting genes. Finally, we demonstrate the broad utility of 3DFAACTS-SNP for functional annotation of any genetic variation using all common (>10% allele frequency) variants from the Genome Aggregation Database (gnomAD). We identified 7,900 candidate variants and 3,245 candidate target genes, generating a list of potential sites for future T1D or autoimmune research. Conclusions: We demonstrate that it is possible to further prioritise variants that contribute to T1D based on regulatory function and illustrate the power of using cell type specific multi-omics datasets to determine disease mechanisms. The 3DFAACTS-SNP workflow can be customised to any cell type for which the individual datasets for functional annotation have been generated, giving broad applicability and utility. Copy rights belong to original authors. Visit the link for more info

Laura talks today with John Greally, a pediatrician and epigenomicist with appointments in Medicine, Pediatrics and Genetics at Einstein Medical Center in the Bronx. John is the founding director of Einstein’s Center for Epigenomics, and an innovator who has looked hard at how to improve the integration of genetic testing into clinical practice.

Personalised Medicine is a priority of governments and research institutes around the world. This podcast episode introduces the topic. Tomorrow we dive a little deeper...

Dr. Joyce Ohm is an Associate Professor of Oncology in the Department of Cancer Genetics and Genomics at the Roswell Park Comprehensive Cancer Center. Joyce’s research examines the epigenomics involved in development and disease, particularly in cancer. In her free time, Joyce enjoys cycling as well as hiking and kayaking with her two adorable dogs. She recently cycled 500 miles from New York City to Niagara Falls in the Empire State Ride, and it was an amazing experience. She was awarded her PhD in Cancer Biology from Vanderbilt University. Afterwards, Joyce conducted postdoctoral research in oncology at Johns Hopkins University School of Medicine. Prior to joining the faculty at Roswell Park, she served on the faculty at the University of North Dakota School of Medicine and Health Sciences. In our interview Joyce tells us more about her life and science.

Samuel Levy of Bluestar Genomics speaks to CHI on March 13, 2019. Dr. Levy will be speaking during The Liquid Biopsy Summit, June 17-19, in San Francisco, CA. Topics include cell-free diagnostics in precision medicine, transformation & growth in the liquid biopsy field, epigenomic assays for cancer detection, and opportunities ahead. For more information, please visit https://www.LiquidBiopsySummit.com/Programs

When we launched the Blood Chemistry Calculator (BCC) in early 2018 we couldn’t have predicted the changes the software would undergo or the projects it would lead to. One such project has been researching and writing a scientific paper on the use of machine learning to predict and interpret biological age. The paper is currently in the peer review process on F1000Research, an open research publishing platform. In this podcast, I talk with lead author Dr. Tommy Wood, MD, PhD, about the importance of knowing your biological age and understanding how it can be derived from basic blood chemistry markers.  Tommy and I discuss the peer-review process and the changes we’re making to the software as a result of the feedback that’s been provided. We also discuss the individual markers that have the greatest impact on biological age, and how you can get a free predicted age report. Here’s the outline of this interview with Tommy Wood: [00:00:58] Tommy got bit by a snake. [00:02:38] Going to the doctor vs. changing lifestyle. [00:03:32] Iatrogenic antibiotic injury. [00:03:49] Antivenom: what it is, what it does and the side effects. [00:06:49] Snake oral microbiota. [00:10:23] Effects of antibiotics on gut. [00:13:29] DUTCH (Dried Urine Test for Comprehensive Hormones). [00:15:54] Our article: An interpretable machine model of biological age. [00:17:15] Why is biological age important? [00:19:12] Other tests of biological age; telomeres. [00:20:31] Epigenetic testing. [00:20:59] Effects of environment on epigenetic methylation; Studies: Nilsson, Emma, and Charlotte Ling. "DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes." Clinical epigenetics 9.1 (2017): 105; and Yet, Idil, et al. "Genetic and environmental impacts on DNA methylation levels in twins." Epigenomics 8.1 (2016): 105-117. Effects of lifestyle change on epigenetic methylation; Studies: Arpón, Ana, et al. "Impact of consuming extra-virgin olive oil or nuts within a Mediterranean diet on DNA methylation in peripheral white blood cells within the PREDIMED-Navarra randomized controlled trial: A role for dietary lipids." Nutrients 10.1 (2018): 15; and Delgado-Cruzata, Lissette, et al. "Dietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in Hispanic, African American, and Afro-Caribbean breast cancer survivors." The Journal of nutrition 145.4 (2015): 783-790. [00:21:05] Epigenetic shifts and aging; Study: Pal, Sangita, and Jessica K. Tyler. "Epigenetics and aging." Science advances 2.7 (2016): e1600584. [00:21:48] Insilico Medicine - Deep Biomarkers of Human Aging: aging.ai. [00:22:46] Blood Chemistry Calculator (BCC). [00:23:33] Find out your biological age with the free partial BCC report. [00:24:04] How the biological age score is determined. [00:28:13] Why we published the paper. [00:28:40] Medscape article: Journal Editors on Peer Review, Paywalls, and Preprints. [00:31:26] F1000Research. [00:33:54] GitHub; XGBoost; Python. [00:35:32] The reviewers for the peer review process: Alex Zhavoronkov and Peter Fedichev. [00:39:10] Ideas that came out of the peer review process. [00:42:49] Shapley Values and SHAP plots. [00:43:51] Machine learning competition website: Kaggle. [00:45:20] The most important blood markers for predicting biological age. [00:48:02] Total cholesterol and BUN for predicting biological age. [00:50:48] Nourish Balance Thrive on Patreon; NBT Forum.

Nature vs. nurture? How about nature and nature? Dr. Candace Lewis, a postdoctoral fellow in the Huentelman lab at TGen, walks us through a biological regulatory framework known as epigenomics that changes the behavior of our cells due to our life experiences. Dr. Lewis also discusses the resurgence in psychedelic assisted therapy to treat depression and trauma, and her work in Autism.

In the fifth Episode of the Epigenetics Podcast of Active Motif our host Dr. Stefan Dillinger sits down with Prof. Henk Stunnenberg, full professor and head of the Department of Molecular Biology at the Radboud University in Nijmegen, to talk about his research in Epigenetics and his contributions to the BLUEPRINT and Human Cell Atlas consortia. References Stunnenberg Lab - http://molbio.science.ru.nl/about/molecular-biology/henk-stunnenberg/ The Blueprint Consortium - http://www.blueprint-epigenome.eu Human Cell Atlas - https://www.humancellatlas.org/ Hendrik G. Stunnenberg, Sergio Abrignani, … Martin Hirst (2016) The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (Cell) DOI: 10.1016/j.cell.2016.11.007 Contact https://twitter.com/epigenetics_pod https://www.linkedin.com/company-beta/35651/ https://www.facebook.com/ActiveMotifInc/ eurotech@activemotif.com

A stimulating session on the implications of genomic data for the management of acute myeloid leukemia (AML) and acute lymphoblastic... The post Acute leukemias discussion: what does genomics and epigenomics tell us about patient management? appeared first on VJHemOnc.

This recording is from the  NorthWest Herb Symposium. Jay and Bridget Johnson of Tree Farm Communications host this excellent event each August in Coupeville, WA. Their next event is August 23rd - 26th, 2018.  LEARN MORE CLASS DESCRIPTION Epigenomics is the study of epigenetic changes in gene expression that occur without commensurate changes in DNA base pair sequences; these changes may be transmissible to subsequent generations. Recent research in the emerging field of Epigenomics strongly supports the probabilities of therapeutic transgenerational herbalism. Epigenomics is developing in response to research showing very convincingly that many cancers are initiated and controlled by transmissible extrachromosomal mechanisms. Ryan Drum, PhD has a BSc in Chemical Technology and a PhD in Botany (Phycology) from Iowa State University. While a NATO Scholar, he did postdoctoral studies on Cell Biology using the Electron Microscope and Microcine at the Universities of Bonn, Germany and Leeds, England. For 10 years he taught Botany and related subjects at Universities (UMASS/Amherst, UCLA, WWU). He studied Herbal Medicine with Ella Birzneck, founder of Dominion Herbal College in British Columbia for 12 years, and taught at their summer seminars for 35 years. He has been an adjunct faculty at Bastyr University since 1984, and he lectures at major herbal conferences and herbal schools. Dr. Drum is the author of over 30 scientific papers in peer-reviewed journals, the author of Electron Microscopy of Diatom Cells 1966, Springer Verlag, a 100-Plate Atlas, in print for 20 years, and a contributing author of two chapters in Planting the Future (Gladstar and Hirsch 2001) and a chapter in Fundamentals of Naturopathic Endocrinology, M. Friedman 2005. The proud father of three wonderful children and two fantastic grandchildren, he lives in a rustic little hilltop cabin he built over 40 years ago on a remote island, off the grid, without indoor plumbing or refrigeration. Ryan believes in true patient autonomy: the freedom and right to choose one's caregivers independent of their official certification. VISIT RYAN ONLINE Thanks for listening to the HerbRally Podcast!  If you've enjoyed please like, share, subscribe or leave a comment! Thanks and much love. HerbRally www.herbrally.com

Noel Doheny, CEO of Epigenomics, spoke with me during Tomorrow Can’t Wait, the 2017 Colorectal Cancer Alliance conference. Epigenomics has developed the first FDA  and PMA approved liquid biopsy test to screen for colorectal cancer. The post A Blood Test to Screen For Colorectal Cancer? Epigenomics Has It appeared first on The Colon Cancer Podcast.

Welcome to the show! Alex wanted to celebrate the "half-way" point for the #YearInSpace mission that was reached earlier this week. So, he invited his Genetics-friends (Neil Crawford & John Neary) over for some beers and to talk about GENETICS in Space, DNA & the Science behind the Year In Space Mission.* 6 months in, 6 more months to go! In case you didn't know, Engineers like to drink. And when they drink, they talk about Science. Hear what it's like to have Engineer Friends on this episode of "DRINKING, WITH ENGINEERS" *THESE ARE THE OPINIONS OF SCIENTISTS & ENGINEERS WHO ARE DRINKING, SO TAKE IT ALL WITH YOUR OWN DISCRETION. BY LISTENING TO THE RAMBLINGS OF THESE OF SCIENTISTS & ENGINEERS, YOU AGREE THAT ANY INFORMATION YOU HEAR MAY NOT BE CORRECT & YOU SHOULD LOOK THEM UP ON YOUR OWN AFTERWARDS. BECAUSE AFTER ALL, WE ARE CONSUMING ALCOHOL. Thanks for listening! Enjoy! SPACE LINKS: Twins Study | The Research - NASA.gov http://www.nasa.gov/twins-study/reseach Epigenomics (pdf) - NASA.gov http://www.nasa.gov/sites/default/files/files/Epigenomics.pdf "Astronaut twins could reveal genetics of space health" - New Scientist https://www.newscientist.com/article/dn23999-astronaut-twins-could-reveal-genetics-of-space-health/ ISS Science for Everyone | Biochemical Profile (Biochem Profile) - 09.16.15 - NASA.gov http://www.nasa.gov/mission_pages/station/research/experiments/1008.html

The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease. Experts from across the Broad Institute community give in-depth introductions to the basic principles of complex trait genetics, including human genetic variation, genotyping, DNA sequencing methods, statistics, data analysis, and more. Videos of these sessions are made freely available for viewing here and are geared toward a wide audience that includes research technicians, graduate students, postdoctoral fellows, and established investigators just entering the field. For more information, please visit: -Program in Medical Population Genetics (http://www.broadinstitute.org/node/224/) -Primer videos (http://www.broadinstitute.org/node/1339/)

Bradley Bernstein (bernsteinlab.org) explains how upcoming advances in epigenomics data on chromatin and genome reorganizations promise to give insights as revolutionary and fundamental as genomic sequences. He also highlights the inadequacies of current visualization methods, particularly for showing data on regulatory elements, cell-types, cell lineage, SNPs, and GWAS. This talk was presented at VIZBI 2011, an international conference series on visualizing biological data (vizbi.org) funded by NIH & EMBO.

Children whose mothers smoked during pregnancy are more likely to have problems like low birth weight, asthma, and possibly obesity, cancer, and high blood pressure. For clues into the mechanism behind these effects, scientists are looking to the epigenome, the personalized set of directions that tells our cells how and when to produce proteins, which is one of the ways gene activity is controlled. In this podcast Stephanie London and Bonnie Joubert discuss the results of their recent study in which they identified a set of genes with methylation changes present at birth in children whose mothers smoked during pregnancy. Visit the podcast webpage to download the full transcript of this podcast.

http://www.einstein.yu.edu - John Greally, M.B., B.Ch., Ph.D., discusses how the vast amount of knowledge gained in the epigenetics research lab can be made useful in a clinical setting to benefit individual patients. Dr. Greally is director of the Center for Epigenomics at Einstein and attending physician, pediatrics, The Children's Hospital at Montefiore. This edition of Einstein On, a research and medicine podcast, is hosted by Gordon Earle, associate dean for communications and public affairs at Einstein.

http://www.einstein.yu.edu - John Greally, M.B., B.Ch., Ph.D., discusses epigenetics (the study of inheritable changes in gene expression that don't result from changes in DNA sequence) in personalized medicine, including how research can help determine an individual's susceptibility to certain diseases, as well as treatments that can modulate epigenetics. Dr. Greally is director of the Center for Epigenomics at Einstein and attending physician, pediatrics, The Children's Hospital at Montefiore. This edition of Einstein On, a research and medicine podcast, is hosted by Gordon Earle, associate dean for communications and public affairs at Einstein.

http://www.einstein.yu.edu - John Greally, M.B., B.Ch., Ph.D., explains, in layterms, the basics of epigenetics (the study of inheritable changes in gene expression that don't result from changes in DNA sequence) in normal human development, aging and heredity, as well as research on its role in cancer, diabetes and infectious diseases. Dr. Greally is director of the Center for Epigenomics at Einstein and attending physician, pediatrics, The Children's Hospital at Montefiore. This edition of Einstein On, a research and medicine podcast, is hosted by Gordon Earle, associate dean for communications and public affairs.