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Intervija tapusi sadarbībā ar Huawei Technologies Latvija.Mēs dzīvojam laikmetā, kad pirmo reizi vēsturē varam objektīvi mērīt un optimizēt savu veselību. Bet tikai tad, ja zinām, ko mērīt un kā iegūtos datus pārvērst konkrētās darbībās.Šajā sarunā ar zinātnieku un ārstu Uģi Klētnieku pievēršamies tēmai, kā mūsdienu tehnoloģijas un jaunākie atklājumi ilgdzīvošanas jomā var palīdzēt pagarināt mūsu veselīgo dzīves laiku. Uģim ir ārsta izglītība, viņš nodarbojas ar pētniecību, ir Longevity Alliance Baltic zinātniskās padomes priekšsēdētājs un Baltic Association of Precison Medicine valdes loceklis, kā arī strādā ar Latvijas olimpiešiem. Viņa zinātniskās intereses ietver dzīvildzes pagarināšanu un novecošanās mehānismus.Sarunā pieminētās informācijas saites atradīsi 231.sarunas lapā.SARUNAS PIETURPUNKTI:0:00 Ievads2:23 Uģa Klētnieka medicīniskā izglītība, profesionālais ceļš un mērķi ilgdzīvošanas jomā7:58 Aizraušanās ar kalnos kāpšanu, riski un laika ieguldījums 11:45 No alpīnisma uz ilgdzīvošanas medicīnu14:30 Slimo aprūpe nav tas pats, kas veselības aprūpe16:30 Darbs ar Latvijas Olimpisko vienību – sportistu ģenētiskie testi un uztura uzlabošana21:00 Par tehnoloģiju izmantošanu olimpiešu uzraudzībai, uzturam un pārtrenēšanās novēršanai23:53 Personīgā pārtrenēšanās pieredze Elbrusā26:49 Jaunākie ilgdzīvošanas zinātnes atklājumi.29:40 Senescentās jeb zombiju šūnas - novecojušo šūnu problēma un risinājumi32:11 Miljardieru investīcijas ilgdzīvošanā - vai bagātie dzīvos mūžīgi?40:28 Ilgdzīvošanas mīti - "zilo zonu" kritiskā analīze43:37 Kāpēc latvieši pēc 40 gadiem sporto tik maz47:25 Nepieciešamie ikdienas paradumi ilgdzīvošanai - četri galvenie pīlāri51:40 Viedpulksteņi un veselības mērījumi optimālai veselībai un sporta sniegumam57:25 VO2 max kā veselības indikators59:53 Viedpulksteņu praktiskā lietošana – pieredze ar Huawei Watch 51:06:20 Iekaisuma procesi fiziskās slodzes ietekmē un to kontrole1:15:03 Treniņu līdzsvara atrašana – risks, kas saistīts ar pārlieku mazu un lielu slodzi
Dr. Sherr is a member of the Undersea and Hyperbaric Medical Society and the Society of Hospitalist Medicine. He has a special interest in the use of HBOT for traumatic brain injury and stroke. New episodes of Welcome to Wellness released every Friday! Not listening on Spotify? Show notes at: https://www.ashleydeeley.com/w2w/scottsherr Episode brought to you by: Dry Farm Wines Episode brought to you by: Thyroid Fixxr (Code: WELCOMEWELLNESS) Episode brought to you by: VieLight (Code: DEELEY10) 10:15: When to use HBOT 13:32: How HBOT helps the brain 21:38 : Senescent or Zombie cells 22:00: Tips for jet lag (say no to carbs!) 25:05: My favorite Methylene Blue 25:40: Troscriptions (trochees) plus My favorite Methylene Blue 33:19: Hard chambers vs. soft chambers Where to find Dr Scott Sherr: Instagram Health Optimization Medicine Website LinkedIn Where to find Ashley Deeley: Website Instagram Facebook YouTube hello@ashleydeeley.com
Are you trying to lower inflammation? Maybe you've got to kill those senescent (aka Zombie) cells to accelerate healing. Learn all about how senolytics taken just once a month and other hacks can add life to your years by helping the body clear cells that are old, yet don't know how to die. Naturopathic physician, senolytic expert and SVP of Product Development at Qualialife Gregory Kelly explains the science behind senescent cells. Dr. Kelly was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. We cover: Senescent cells, zombie cells How to get rid of them Who needs to be concerned about senescent cell build up What it means What's better - fasting or supplements What women in peri and post menopause need to know about senescent cells Senescent cells and menopause Incredible results for women with joint pain and fatigue Get qualialife.com/hackmyage code HACKMYAGE 15% off Contact Gregory Kelly and Qualia: Website: https://qualialife.com/hackmyage Facebook: https://www.facebook.com/Qualialife Instagram: https://www.instagram.com/qualialife/ LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/ Give thanks to our sponsors Qualia senolytics and brain supplements. 15% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA here. Get Mitopure Urolithin A by Timeline. 10% discount with code ZORA at https://timeline.com/zora Visit https://getkion.com/zora for 20% off Kion Essential Amino Acids Try OneSkin skincare for with code ZORA at https://shareasale.com/r.cfm?b=2685556&u=4476154&m=102446&urllink=&afftrack= Join Biohacking Menopause before February 1, 2025 to win Kion Essential Amino Acids. 20% off with code ZORA at https://getkion.com/zora https://biohacking-menopause.mn.co Join the Hack My Age community on: Facebook Page : @Hack My Age Facebook Group: @Biohacking Menopause Instagram: @HackMyAge Website: HackMyAge.com Membership group: Biohacking Menopause Email: zora@hackmyage.com This podcast is edited by jonathanjk@gmail.com
In this episode, Dr. Mary Alice Mina discusses the key takeaways from her interview with Dr. Cory Goldberg, focusing on achieving timeless, beautiful skin through a holistic approach. She emphasizes the importance of skin health, lifestyle choices, nutrition, exercise, and the role of sun protection. Dr. Mina also highlights the significance of understanding senescent cells in aging and the need for ethical practices in aesthetics. Tune in for key insights from the latest podcast episode featuring Dr. Cory Goldberg. Key Takeaways: - True beauty and aesthetics come from the inside out. - Skin health is paramount for overall health. - Lifestyle choices make up 90% of skin health. - An ounce of prevention is worth a pound of cure. - Nutrition plays a crucial role in skin health. - Resistance training is essential as we age. - Senescent cells contribute to aging and need to be addressed. - Sun protection is vital for maintaining youthful skin. - Seek ethical care from trained professionals in aesthetics. - A holistic approach to aesthetics yields the best results. Follow Dr. Mina here:- https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin https://www.linkedin.com/in/drminaskin/ For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Website- https://www.atlantadermsurgery.com/ Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.
Have you ever stopped to think about how the health of your skin might be the first indicator of your overall well-being? Could the antioxidants you're consuming be the key to preventing cellular damage and inflammation? In this episode of the Peak Human Labs Podcast, Dr. Goel sits down with Dr. Cory Goldberg, a leading plastic surgeon and longevity expert, to discuss the powerful connection between skin health and overall wellness. They dive into how antioxidants can help maintain youthful skin, the benefits of exosomes, and why skin health is such a clear indicator of your body's overall well-being. Dr. Goldberg also shares insights on "Beauty Span"—a holistic approach to beauty that goes beyond the surface. Plus, he offers expert advice on skincare, sun protection, and the surprising benefits of supplements like glycine and superoxide dismutase (SOD). Tune in to discover how you can improve both your skin and overall health. Don't forget to subscribe for more cutting-edge insights on health, longevity, and holistic well-being! Key Takeaways The relationship between antioxidants and overall health. The role of oxidative stress in aging and inflammation. The significance of skin health as an indicator of overall bodily wellness. The functions and potential applications of stem cells and exosomes in health. The impact of UV radiation on skin health and cellular damage. The effectiveness and limitations of topical antioxidants, particularly vitamin C. The importance of dietary sources of antioxidants and their practical limitations. The role of the enzyme superoxide dismutase (SOD) in combating oxidative stress. The concept of "beauty span" is a holistic approach to maintaining beauty through health. The connection between skincare practices and overall well-being. In This Episode: [00:00:00] Introduction to oxidative stress [00:00:33] Host introduction [00:01:17] Guest introduction [00:01:45] Dr. Goldberg's background [00:04:14] Stem cell functionality [00:05:51] Stem cell injection methods [00:09:54] Stem cells in joint treatment [00:10:50] Exosomes discussion [00:12:32] Risks of exosome use [00:13:30] Plant-derived exosomes [00:14:54] Senescent cells and skin health [00:16:10] Sun exposure and senescent cells [00:16:27] Reversibility of senescent cells [00:17:50] Bidirectional health and beauty [00:18:00] Importance of skincare [00:24:37] Dietary sources of antioxidants [00:25:55] Superoxide dismutase (SOD) Importance [00:27:45] Efficacy of antioxidants in studies [00:31:11] Genetic variability in SOD production [00:31:51] Glycerin supplement availability [00:32:38] Patient outcomes with glycerin [00:33:38] Research and studies on glycerin [00:35:39] Plans in longevity [00:37:14] Beauty span concept [00:37:41] Resources and contact information [00:38:33] Key takeaways from the episode Our Guest Dr. Cory S. Goldberg is a highly skilled plastic surgeon based in Toronto, specializing in a range of aesthetic procedures. With a background in Biomedical Engineering and Craniofacial Surgery, he offers cutting-edge treatments in breast augmentation, facelifts, rhinoplasty, and body contouring. Dr. Goldberg is renowned for his personalized approach to patient care and his use of advanced technologies, such as Vectra 3D Imaging, to ensure optimal results. His expertise is complemented by a strong commitment to enhancing both beauty and wellness, making him a sought-after choice for those looking to improve their appearance with precision and care. Resources and Links Peak Human Labs https://www.youtube.com/@peakhumanlabs/videos https://www.peakhuman.ca/ https://www.instagram.com/peakhumanlabs/?hl=en https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724 Dr. Sanjeev Goel https://www.linkedin.com/in/sanjeevgoelmd/?originalSubdomain=ca Dr. Cory Goldberg https://www.corygoldbergmd.com/ https://www.youtube.com/c/drcorygoldberg https://www.instagram.com/drcorygoldbergmd/ https://www.linkedin.com/in/corygoldbergmd/?originalSubdomain=ca www.Beautyspan.com www.healthspan.digital www.GliSODin.org Products: ASCE Rose Cell Exosomes GliSODin
Send us a textIn this insightful episode, I am joined by Chris Mirabile, a visionary in the field of longevity and the founder of Novos, a company at the forefront of combating aging through science-backed strategies and natural innovations. Chris shares his personal journey of health challenges and triumphs, which led him to a lifelong commitment to understanding the science of aging and optimizing human potential. His mission to bridge the gap between cutting-edge biotech and accessible health solutions has made him a trailblazer in the field of longevity.Our conversation dives deep into the 12 hallmarks of aging, a revolutionary framework for understanding the biological mechanisms behind the aging process. We also explore actionable lifestyle changes and the synergistic role of nutrition, supplements, and mindfulness in enhancing healthspan and lifespan. From the potential of senescent cell management to the transformative power of personalized health strategies, Chris provides valuable insights for anyone seeking to live a longer, healthier, and more vibrant life. Tune in to uncover the secrets to slowing aging and unlocking your full potential.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today's Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode: Health transformation through adversity [00:01:22]Health transformation through adversity [00:05:06]Defining aging at the cellular level [00:09:41]Novos Longevity Diet Optimization [00:12:29]Nutrient inadequacies in modern diets [00:17:04]Testing for vitamin levels [00:20:29]Iron levels and health risks [00:24:51]12 hallmarks of aging [00:29:22]Cellular senescence and longevity [00:31:51]Fasting mimetics and longevity [00:35:54]Trace doses of lithium benefits [00:39:44]Telomere shortening and lifespan [00:45:10]Stem cell exhaustion and aging [00:48:17]Microbiome dysbiosis and health [00:51:31]Synergistic effects of formulas [00:56:48]Lifestyle strategies affecting aging [01:03:12]Nervous system's impact on supplements [01:06:07]Longevity accessibility for everyone [01:10:34]Slowing down aging [01:12:17] SlowMyAgeWebsiteNovos LabsWebsiteNovos Life AppFree mobile app available on iOS and Android, featuring a biological age test, personalized lifestyle guidance, and integrated LLM (AI-powered guidance).PeopleChris MirabileLinkedIn ProfileInstagram (@slowmyage)Andrés PreschelLinkedIn ProfileInstagram (@andrespreschel)Twitter (@andrespreschel)Dan BuettnerWikipediaBluSupport the show
Angela talks to Dr Alessandra Zonari the chief scientific officer and founding member of OneSkin. They explore the critical role of collagen in maintaining youthful skin, the impact of senescent cells—often referred to as "zombie cells"—on skin health, and how OneSkin's innovative OSO-1 peptide targets these cells to promote collagen production and improve skin function. Dr. Zonari also shares her journey from academia to developing groundbreaking skincare solutions, emphasising the importance of a holistic approach to skin health that includes lifestyle factors such as diet, sleep, and sun protection. KEY TAKEAWAYS Research indicates that the skin around the eyes is biologically 20 to 30 years older than the skin on other parts of the face, highlighting the need for targeted skincare in this area. Senescent cells, often referred to as "zombie cells," accumulate with age and secrete inflammation, leading to collagen breakdown and impaired skin function. Targeting these cells is crucial for maintaining youthful skin. Collagen is essential for skin firmness and elasticity. Its production declines with age, particularly due to hormonal changes in women during menopause, which can exacerbate skin aging. The patented OSO-1 peptide is designed to reduce the burden of senescent cells, promote collagen production, and improve overall skin health. Continuous use can lead to long-term improvements in skin appearance and function. BEST MOMENTS "Senescent cells, also known as zombie cells, are damaged cells that start accumulating on the skin and produce inflammation, leading to collagen breakdown." "I tried so many products over the years... but they rarely deliver real visible results." "When we are getting older, the skin tissue starts to accumulate damage on the cells, and the cells that accumulate damage secrete inflammation." "I first discovered OneSkin's products at a biohacking event, and I'll admit I was a bit skeptical at first, but I am so glad that I did." "The OS1 peptide is a novel molecule that was specifically designed to target the accumulation of those zombie cells in the skin." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community Learn more about the science behind OneSkin and save 15% with code ANGELA at oneskin.co/angela Get 25% Off Bon Charge Red Light Therapy Face Mask ABOUT THE GUEST CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.
Alessandra Zonari, PhD is the co-founder and Chief Scientific Officer at OneSkin, but she isn't your typical scientist. She's a visionary with a passion for longevity, skin regeneration, and the occasional karaoke jam. After earning a degree in stem cell biology, and a doctorate in skin regeneration and tissue engineering, Alessandra joined OneSkin in 2017 as a founding member and Chief Scientific Officer. Her contributions include 20+ papers, 3 patents, and the development of their proprietary OS-01 peptide. Try One Skin at 15% off with code ZORA at oneskin.co/ZORA Contact Alessandra Zonari and One Skin: website: https://www.oneskin.co Instagram: https://www.instagram.com/oneskin.co/linkedin: https://www.linkedin.com/company/oneskin/ Get Primeadine by Oxford Healthspan. 15% discount with code ZORA here. Get Mitopure by Timeline. 10% discount with code ZORA at timeline.com/zora Try Magnesium Breakthrough by Bioptimzers. 10% discount with code HACKMYAGE at bioptimizers.com/hackmyage Join Biohacking Menopause before December 1, 2024 to win one of 3 copies of The Psilocybin Handbook for Women by Jennifer Chesak. Join the Hack My Age community on: Facebook Page : @Hack My Age Facebook Group: @Biohacking Menopause Instagram: @HackMyAge Website: HackMyAge.com Biohacking Menopause membership group Email: zora@hackmyage.com This podcast is edited by jonathanjk@gmail.com We cover: - How hormones affect skin - Should we care about wrinkles and aging skin? - What are senescent skin cells - Can skin formulations kill senescent cells? - Can stem cells repair tissue after an operation? - Which peptides are best for menopausal skin concerns? - Which are the best prevention methods for aging skin? - What to look out for in a good skincare product - Which ingredients and products do more harm than good - Why the OS-01 peptide is even better than other peptides - My personal experience with the One Skin brand --- Support this podcast: https://podcasters.spotify.com/pod/show/hackmyage/support
In this installment of the Longevity & Aging Series, Dr. Ming Yu and Namita Hattangady from the Fred Hutchinson Cancer Center in Seattle, join host Dr. Evgeniy Galimov to discuss a research paper they co-authored that was published as the cover for Volume 16, Issue 4 of Aging (Aging-US), entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” DOI - https://doi.org/10.18632/aging.205577 Corresponding authors - William M. Grady - wgrady@fredhutch.org, and Ming Yu - myu@fredhutch.org Video interview - https://www.youtube.com/watch?v=eqSa7My_a7w Interview transcription - https://www.aging-us.com/interviews/longevity-aging-series-s2-e2-dr-ming-yu-and-namita-hattangady Abstract Advanced age is the largest risk factor for many diseases and several types of cancer, including colorectal cancer (CRC). Senescent cells are known to accumulate with age in various tissues, where they can modulate the surrounding tissue microenvironment through their senescence associated secretory phenotype (SASP). Recently, we showed that there is an increased number of senescent cells in the colons of CRC patients and demonstrated that senescent fibroblasts and their SASP create microniches in the colon that are conducive to CRC onset and progression. However, the composition of the SASP is heterogenous and cell-specific, and the precise senescence profile of colon fibroblasts has not been well-defined. To generate a SASP atlas of human colon fibroblasts, we induced senescence in primary human colon fibroblasts using various in vitro methods and assessed the resulting transcriptome. Using RNASequencing and further validation by quantitative RT-PCR and Luminex assays, we define and validate a ‘core senescent profile' that might play a significant role in shaping the colon microenvironment. We also performed KEGG analysis and GO analyses to identify key pathways and biological processes that are differentially regulated in colon fibroblast senescence. These studies provide insights into potential driver proteins involved in senescence-associated diseases, like CRC, which may lead to therapies to improve overall health in the elderly and to prevent CRC. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205577 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, senescence associated secretory phenotype, SASP, colorectal cancer, cancer About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout Link to show notes: https://bit.ly/4gdmxES Key Takeaways: 02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.
Chuck Edwards - "Downtown Soulville" - 45 [0:00:00] Music behind DJ: The Upsetters - "Jaywalking" - 45 [0:04:04] Larry O'Dell - "Nab Jones" - 45 [0:04:43] Sonny Forrest - "Mama, Keep My Wife at Home" - 45 [0:06:41] Little Joe Hinton - "Let's Start a Romance" - 45 [0:09:08] Little Nicky Soul - "I Wanted to Tell You" - 45 [0:11:43] Music behind DJ: Don Pierce - "20th Century" - 45 [0:13:56] Oliver Joy - "Keep Love Growing" - 45 [0:16:10] Carol Anderson - "Taking My Mind Off Love" - 45 [0:18:37] Bobby Garrett - "My Little Girl" - 45 [0:20:42] Barbara Mercer - "Call On Me" - 45 [0:23:17] The Tempos - "I'll Never Forget" - 45 [0:25:44] Music behind DJ: Lynn August - "Black Olives" - 45 [0:28:21] Tony Troutman - "So Much, She's Gone Away" - 45 [0:30:59] Harmonica George - "Freelance" - 45 [0:32:52] Willie Mabon - "I Won't Be Back No More" - 45 [0:35:21] Hosea Leavy & His Combo - "Oo-Wee Baby" - 45 [0:37:44] Music behind DJ: Willey Terry - "The Upslide" - 45 [0:40:22] Johnny Moore - "That's What You Said" - 45 [0:42:43] Lynn Williams - "How Can You Call Love Fascination" - 45 [0:44:53] Pointer Sisters - "Send Him Back" - 45 [0:46:59] Black Velvet - "An Earthquakes Coming (If You Don't Straighten Up)" - 45 [0:49:41] Lou Pride - "Phoney People" - 45 [0:52:08] Richard Knight - "Show Stopper" - 45 [0:54:22] Music behind DJ: L. Gardner and Orch. - "Senescent" - 45 [0:57:01] https://www.wfmu.org/playlists/shows/143541
Dr. Peter Lidsky posits that aging is not merely a process of accumulating damages, as commonly believed, but rather a programmed adaptation akin to a part of the immune system. His hypothesis suggests that aging evolved to eliminate older individuals who might be susceptible to severe chronic diseases. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8 About the showThe Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. Learning with lowell linksYoutube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips:https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Peter Lidsky linkshttps://twitter.com/LidskyPeterhttps://www.linkedin.com/in/peter-lidsky-71997540 Timestamps00:00 Start00:10 who is Peter Lidsky / research / longevity01:30 Academia differences04:20 Aging explained and the Squirrel test07:20 Pathogen control hypothesis15:50 Lifespans different organisms (fanq)17:55 Natural experiments to prove/disprove (fanq)24:30 Implications of Theory of aging25:00 Senescent cells31:32 Therapeutics / interventions from his research33:00 Implications of his theory37:50 Limits of aging40:10 What do people need to see to believe his theory44:30 Show him the drug that is better than rapamycin46:40 Data sharing / organization to push forward48:50 What is slowing aging research49:50 Pleiotropic genes / aging52:00 Research at Hong Kong52:40 Focus of future research53:55 Devices for research56:00 Bryan Johnson Blueprint59:20 People to follow01:00:00 place to stay up to date01:01:30 Thanks for all the fish longevity #aging #agingresearch
BUFFALO, NY- July 17, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 13, entitled, “Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells.” Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited therapeutic options. Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II (ATII) cells, has recently been identified as a potential trigger event for the progressive disease cycle. Targeting ATII senescence and the senescence-associated secretory phenotype (SASP) is an attractive therapeutic strategy; however, translatable primary human cell models that enable mechanistic studies and drug development are lacking. In this new study, researchers Joseph S. Spina, Tracy L. Carr, Lucy A. Phillips, Heather L. Knight, Nancy E. Crosbie, Sarah M. Lloyd, Manisha A. Jhala, Tony J. Lam, Jozsef Karman, Meghan E. Clements, Tovah A. Day, Justin D. Crane, and William J. Housley from AbbVie Bioresearch Center and Northeastern University describe a novel system of conditioned medium (CM) transfer from bleomycin-induced senescent primary alveolar epithelial cells (AEC) onto normal human lung fibroblasts (NHLF) that demonstrates an enhanced fibrotic transcriptional and secretory phenotype compared to non-senescent AEC CM treatment or direct bleomycin damage of the NHLFs. “In the current study, we confirm the presence of senescent cell populations within the human IPF lung, as well as assess primary cell reagents for sensitivity to senescent cell targeting therapies.” In this system, the bleomycin-treated AECs exhibited classical hallmarks of cellular senescence, including SASP and a gene expression profile that resembles aberrant epithelial cells of the IPF lung. Fibroblast activation by CM transfer was attenuated by pre-treatment of senescent AECs with the senolytic Navitoclax and AD80, but not with the standard of care agent Nintedanib or senomorphic JAK-targeting drugs (e.g., ABT-317, ruxolitinib). This model provided a relevant human system for profiling novel senescence-targeting therapeutics for IPF drug development. “Taken together, the model described herein provides a physiologically relevant, primary human cell system to study the effects of alveolar epithelial cell senescence on lung fibroblasts in the context of chronic fibrotic lung disease.” DOI - https://doi.org/10.18632/aging.205994 Corresponding author - Tovah A. Day - t.day@northeastern.edu Video short - https://www.youtube.com/watch?v=rpmo2PlGDKc Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205994 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
BUFFALO, NY- July 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 13, entitled, “Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice.” Senescent cells contribute to tissue aging and underlie the pathology of chronic diseases. The benefits of eliminating senescent cells have been demonstrated in several disease models, and the efficacy of senolytic drugs is currently being tested in humans. Exercise training has been shown to reduce cellular senescence in several tissues; however, the mechanisms responsible remain unclear. In this new study, researchers Hiromichi Tsushima, Hirobumi Tada, Azusa Asai, Mikako Hirose, Tohru Hosoyama, Atsushi Watanabe, Taro Murakami, and Masataka Sugimoto from Tokyo Metropolitan Institute for Geriatrics and Gerontology, Shigakkan University, and National Center for Geriatrics and Gerontology investigated myocyte-secreted factors with the potential to suppress cellular senescence, aiming to explore their protective effects against lung disease. “We found that myocyte-derived factors significantly extended the replicative lifespan of fibroblasts, suggesting that myokines mediate the anti-senescence effects of exercise.” A number of proteins within myocyte-derived factors were identified by mass spectrometry. Among these, pigment epithelium-derived factor (PEDF) exerted inhibitory effects on cellular senescence. Eight weeks of voluntary running increased PEDF levels in skeletal muscles and suppressed senescence markers in the lungs. The administration of PEDF reduced senescence markers in multiple tissues and attenuated the decline in respiratory function in the pulmonary emphysema mouse model. The researchers also showed that blood levels of PEDF inversely correlated with the severity of COPD in patients. “Collectively, these results strongly suggest that PEDF contributes to the beneficial effects of exercise, potentially suppressing cellular senescence and its associated pathologies.” DOI - https://doi.org/10.18632/aging.205976 Corresponding authors - Masataka Sugimoto - msugimot@tmig.or.jp Video short - https://www.youtube.com/watch?v=Bzgb2PEiV9c Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205976 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, exercise, PEDF, myokine, COPD About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
BUFFALO, NY- July 1, 2024 – A new #review paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, “Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?” Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. In this new review, researchers João Pessoa, Sandrina Nóbrega-Pereira, and Bruno Bernardes de Jesus from the University of Aveiro describe the current knowledge in this field. “In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.” DOI - https://doi.org/10.18632/aging.205975 Corresponding authors - Bruno Bernardes de Jesus - brunob.jesus@ua.pt Video short - https://www.youtube.com/watch?v=hbhkSu1kX5Y Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205975 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cancer, immunotherapy, tumor-associated senescent cells, senescence, antigen, vaccine About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
Welcome! and Thank you for listening. We age and our cells age. About every three months our red blood cells turn over for example. What happens to the old cells? How do we eliminate them? Our immune system plays a vital role in eliminating old cells or senescent cells. Unfortunately, our immune system also slows down so we start to accumulate these "zombie" senescent cells. This month Nature magazine discusses new drugs and repurposed drugs to eliminate these cells. However, these medications also have side effects and substantial costs. Since we all age, should everyone start these medications or do we wait until there is a problem like diabetes, Alzheimers, or vascular disease? Another alternative might be to decrease the amount of zombie cells in the first place or protect our immune system so it functions longer. You guest it. Nutrition and exercise play a key role as an alternative to decrease zombie cell accumulation. Thanks for listening. If you want help preventing zombie cell accumulation or to enhance your health span, check out our website at doctordulaney.com https://www.amazon.com/Plant-based-Wellness-Cookbook-Generations-Cooking/dp/1733967702/ref=sr_1_3?crid=1U4J4U0SZUXUF&dchild=1&keywords=plant+based+wellness+cookbook&qid=1621083696&sprefix=plant+based+well%2Caps%2C173&sr=8-3 https://mypurewater.com/?sld=jdulaneyhttps://www.nature.com/articles/d41586-024-01370-4
With an ever-increasing global population grappling with age-related ocular ailments like cataracts, dry eyes, glaucoma, and macular degeneration, the need for new research in this domain is more pressing than ever. In a new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from the Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center shed light on a pivotal aspect of corneal health – the impact of ultraviolet-A (UV-A) radiation on corneal endothelial cells. Their research paper was published on the cover of Aging's Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.” “The objective of this study was to investigate the senescent phenotypes of human corneal endothelial cells (hCEnCs) upon treatment with ultraviolet (UV)-A.” Full blog - https://aging-us.org/2024/05/uv-a-exposure-cellular-senescence-and-vision-impairment/ Paper DOI - https://doi.org/10.18632/aging.205761 Corresponding author - Koji Kitazawa - kkitazaw@koto.kpu-m.ac.jp Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205761 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, senescence-associated secretory phenotype, RNA-Seq, proteomics, gene ontology analysis About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
Today, I am thrilled to connect with Dr. Nick Bitz, a renowned naturopathic physician specializing in Ayurvedic medicine. Dr. Bitz is an influential figure in the natural products industry, specializing in nootropics, anti-aging, medicine, biohacking, herbology, nutrition, and dietary supplements. He is currently the Senior Vice President of Product Development at Neurohacker Collective. In our discussion, we cover cellular senescence, zombie cells, and distinctions with autophagy, highlighting some hallmarks of the aging process. We discuss the gut microbiome and the significance of akkermansia, also exploring the impact of senomorphics and senolytics, brain aging, lifestyle factors, the challenges of sarcopenia, and anabolic resistance. Join us for today's enlightening conversation with Dr. Nick Bitz as we journey into various aspects of holistic health and wellness. IN THIS EPISODE YOU WILL LEARN: How modern lifestyle factors exacerbate age-related cellular dysfunction Why it is critically important to consume enough fiber each day Senescent cells and their impact on aging, health, and disease What is the difference between senolytics and senomorphics? How senolytics get used in a clinical setting to target different body parts Diet, lifestyle, and supplements for brain health How adaptogens are used in Ayurvedic medicine The role of senescent cells in muscle aging Dr. Bitz discusses the popular senolytic product he created with Neurohacker Collective Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Nick Bitz Neurohacker Collective Collective Insights Podcast Use the code EverydayWellness to save 15% on any Qualia formulation
BUFFALO, NY- April 30, 2024 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.” In this new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center investigated the senescent phenotypes of human corneal endothelial cells (hCEnCs) upon treatment with ultraviolet (UV)-A. “We assessed cell morphology, senescence-associated β-galactosidase (SA-β-gal) activity, cell proliferation and expression of senescence markers (p16 and p21) in hCEnCs exposed to UV-A radiation, and senescent hCEnCs induced by ionizing radiation (IR) were used as positive controls.” The researchers performed RNA sequencing and proteomics analyses to compare gene and protein expression profiles between UV-A- and IR-induced senescent hCEnCs — they also compared the results to non-senescent hCEnCs. Cells exposed to 5 J/cm2 of UV-A or to IR exhibited typical senescent phenotypes, including enlargement, increased SA-β-gal activity, decreased cell proliferation and elevated expression of p16 and p21. RNA-Seq analysis revealed that 83.9% of the genes significantly upregulated and 82.6% of the genes significantly downregulated in UV-A-induced senescent hCEnCs overlapped with the genes regulated in IR-induced senescent hCEnCs. Proteomics also revealed that 93.8% of the proteins significantly upregulated in UV-A-induced senescent hCEnCs overlapped with those induced by IR. In proteomics analyses, senescent hCEnCs induced by UV-A exhibited elevated expression levels of several factors part of the senescence-associated secretory phenotype. “In this study, where senescence was induced by UV-A, a more physiological stress for hCEnCs compared to IR, we determined that UV-A modulated the expression of many genes and proteins typically altered upon IR treatment, a more conventional method of senescence induction, even though UV-A also modulated specific pathways unrelated to IR.” DOI - https://doi.org/10.18632/aging.205761 Corresponding author - Koji Kitazawa - kkitazaw@koto.kpu-m.ac.jp Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205761 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Dive into the fascinating world of cellular aging and longevity with our guest expert, Dr. Greg Kelly. Dr Kelly is a fellow naturopathic physician & the vice president of product development at Qualia from Neurohacker Collective. From unraveling the mysteries of senescent cells to exploring cutting-edge regenerative medicine, we explore the intricate processes underlying aging and how they impact our health. Discover the role of stress, metabolism, and the immune system in the formation and clearance of senescent cells, and learn about the innovative work of Qualia by Neurohacker Collective. Tune in for a deep dive into the science of aging and practical insights for optimizing your cellular health. If you ALSO want to Resist aging at the cellular level, try Qualia Senolytic. Go to neurohacker.com/DRTYNA for up to $100 off and use code DRTYNA at checkout for an additional 15% off. On This Episode We Cover: 2:22 - Defining senescent cells 4:50 - The resources senescent cells use 6:46 - The causes of senescent cells & the hayflick limit 10:08 - Researching and tracking senescent cells in the body 14:59 - Stress on a cellular level & senescent cell accumulation 18:23 - Apoptosis & how to “detox” senescent cell 19:33 - Balancing autophagy 20:52 - Senescent cell prevention 23:33 - Types of cell death 26:21 - Quiescent cells 31:16 - Joint health & muscle tissue 34:50 - Senescent cells & organ transplantation 36:01 - Age reversal studies 38:53 - The microbiome and senescent cells 40:22 - The hallmarks of aging 41:36 - Polyphenols & alkaloids in the gut 43:34 - Senolytic supplements 46:23 - Hit & run dosing 52:29 - Other ways of preventing senescent cells 54:08 - Qualia pilot studies 58:40 - Qualia protocols 1:01:121- What to look out for while taking Qualia Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Subscribe to our channel: https://www.youtube.com/@optispan Senescent cells, cells that cease to divide and proliferate while remaining metabolically active, are a complex and intriguing aspect of biological aging. They serve as both a protective mechanism against cancer, preventing damaged cells from uncontrollable replication, as well as a contributor to tissue dysfunction and age-related pathologies such as cardiovascular disease, neurodegenerative disorders, and diabetes. The precise mechanisms that underlie senescence and its contributions to the aging process remain areas of ongoing investigation and debate. In this episode, Matt chats with Sapere Bio co-founder and CEO Natalia Mitin about measuring cellular senescence, using those measurements in the clinic, and the complex and heterogeneous role of cellular senescence in aging and disease. They also discuss Natalia's personal experiences using rapamycin off-label to improve energy levels and immune function, the importance of monitoring biomarkers when using off-label medications, and Natalia's thoughts on "rapamycin for all". Prior to co-founding Sapere Bio, Natalia served as an assistant professor at the University of North Carolina at Chapel Hill's Department of Pharmacology. She spent over two decades developing assays for use in cancer research. She holds a B.S. in chemical engineering from the Mendeleev Institute for Chemical Technology and a PhD in biochemistry and molecular biology from Bowling Green State University. Optispan uses the SapereX test in its healthspan optimization program. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!
Is rapamycin the key to unlocking the fountain of youth?Scientists are exploring various ways to inhibit aging and one of the potential pharmaceutical interventions is the use of rapamycin. In this episode, Dr. Charles Mok explores rapamycin cream, its origins, applications, and potential benefits to slow down the aging process.Rapamycin, also known as sirolimus, was discovered several decades ago and has captivated doctors and patients for its minimizing impact on aging. Studies have shown that rapamycin not only inhibits tumor growth and organ transplant rejection but reverses aging in various animals,including mammals.Rapamycin appears to suppress the conversion of young cells into old cells, called senescence. Senescent cells, known for their toxic effects, contribute to the development of wrinkles and saggy skin. Dr. Charles Mok shares findings from studies using rapamycin cream on healthy volunteers, revealing younger-looking skin with increased collagen and fewer senescent cells.Dr. Charles Mok stresses that rapamycin cream is not a replacement for standard skincare practices like sunblock or topical vitamin C and retinol. Instead, it serves as an adjunct therapy for individuals seeking to reverse skin damage.Tune in to this new episode of Inside The Cure podcast — Rapamycin: What You Should KnowSubscribe to Inside the Cure and don't forget to leave a 5-star review!Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/Instagram: https://www.instagram.com/alluremedicals/Website: https://www.alluremedical.com/YouTube: https://www.youtube.com/@AllureMedicalAmazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true #rapamycin #sirolimus #antiaging #skincare #healthyskin
Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources. *Guest information* Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. greg@neurohacker.com https://www.facebook.com/neurohackercollective https://www.instagram.com/neurohacker/ https://www.linkedin.com/in/gregory-kelly-98b96b138/ *Qualia Discount for New Frontiers Listeners* If you're in your late 20's or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/3zpsaw3s for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase. *Show Notes* Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly Neurohacker Collective: https://tinyurl.com/3zpsaw3s Shape Shift: https://tinyurl.com/3zpsaw3s Alternative Medicine Review: https://tinyurl.com/56ad9av9 Textbook of Natural Medicine: https://tinyurl.com/56ad9av9 Qualia Studies: https://neurohacker.com/studies Inulin-Type Probiotics - A Review (Part 1 and 2): https://altmedrev.com/?s=inulin James Schmachtenberger: https://tinyurl.com/yjhkj8k9 Daniel Schmachtenberger: https://tinyurl.com/yz2da5r4 Quercefit: https://tinyurl.com/4646pu8p Study: The Hallmarks of Aging: https://tinyurl.com/5cdnnbuy Study: Hallmarks of aging: An expanding universe: https://tinyurl.com/2y8dtx27 The Achilles' heel of senescent cells: from transcriptome to senolytic drugs: https://tinyurl.com/3k2sxkrb The Clinical Potential of Senolytic Drugs: https://tinyurl.com/5xdy2kk9 Epigenetic clock analyses of cellular senescence and ageing: https://tinyurl.com/4vxany6p The relationship between epigenetic age and the hallmarks of aging in human cells: https://tinyurl.com/34m626a2 Qualia Mind: https://tinyurl.com/23xv42fj Vittorio Sebastiano: https://tinyurl.com/4md5xvxh *DrKF Resources* FxMed Blog: The 12 biological hallmarks of aging viewed through a functional medicine and functional longevity lens: https://tinyurl.com/5n6c5b84 Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano: https://tinyurl.com/2z54h5h8 DrKF Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/ Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/ Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/ Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/ Younger You book: https://youngeryouprogram.com/book/ Dr. Fitzgerald is actively engaged in award-winning clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice. She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women and is the author of the bestselling book Younger You: How to Reduce Your Bio Age and Live Longer, Better.
What is the root cause of many age-related diseases? Cellular senescence happens when a healthy, functioning cell ceases to divide, but doesn't die. Senescent cells can accumulate, and their synthetic behavior can become erratic. As they begin to function in abnormal ways, they can lead to some of the diseases we fear the most: cancer, degenerative disease, liver dysfunction, etc. Through a new approach I call seno-ablation, it may be possible to use natural killer cells to remove - or I like to use the term prune - these senescent cells. This could be a major advancement in combating serious disease. In this episode, I talk about seno-ablation and some of the advancements that are being made in the eradication of senescent cells.Follow Dr. Bob Hariri on his platforms here:Web: www.pilotinghealth.comInstagram: https://www.instagram.com/drbobhariri/X: https://twitter.com/DrBobHaririTikTok: https://www.tiktok.com/@pilotinghealthLinkedIn: https://www.linkedin.com/in/drbobhariri/
This week I interview longevity queen, Dr Sandra Kaufmann the author of the Kaufmann Protocol and Aging Solutions. Dr Sandra is the head of department of Anesthesiology at and just happens to be obsessed with longevity science. What started out as her own search to slow and reverse ageing turned into a comprehensive system that allows people to personalize their own regime to their particular set of problems or needs and goals. This ingenious system has revolutionized my approach and makes it so simple to construct a very personalized approach. There are innumerable things a person can read concerning aging, but at the most basic level, organisms age because their component cells age. We are all made of cells or cell products and as they falter, so do we. Because cell aging is multifactorial, the organization of these concepts is important. The Protocol organizes these various theories of cellular aging into seven categories or tenets. The information in this podcast discusses these concepts in the language of science. The following seven tenets encompass all of the presently known modes of cellular aging. Based on this organizational scheme, Dr Kaufman then developed a strategy where aging is curtailed in every category. The 7 Tenets are as follows: DNA alterations (telomere attrition, epigenetics) Mitochondrial failure Pathways (Sirtuins, AMP Kinase, mTOR) Quality control (DNA & Protein repair mechanisms and Autophagy) Immune and inflammatory systems Individual cell needs (Senescent, Stem cells) Waste management (Glycation, lipofuscin) Dr Kaufman explains her rating system for various longevity molecules and how to utilize these in your protocols. We also discuss many of the supplements and adjuvants that Dr Kaufmann recommends for each of these tenets and we look at other cutting edge regenerative modalities like Exosomes. Stem cells are fantastic in terms of longevity, however there are limitations. Exogenous stem cells are currently not available in this country. Meanwhile, autologous stem cells are only as healthy as the person they which they come. Exosomes, on the other hand, constitute up to 80% of the benefits seen with stem cells and are available through Dr Kaufmann in the United States at least, in addition to being less expensive. I highly recommend Dr Kaufman's books, these are major reference book that will serve those looking to optimise their health, performance and longevity. Links Below Dr Sandra Kaufmanns website https://kaufmannprotocol.com/ Dr Sandra's Books: The Kaufmann Protocol Book Aging Solutions Book If you are interested in getting Exosomes done after listening to the episode join Dr Kaufmann's interview reach out to me at support@lisatamati.com Instagram: @kaufmanantiaging BIO Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital, a nationally recognized center of excellence. Most recently, she was recognized as "Best in Medicine" by the American Health Council. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . 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Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38 Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. 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When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don't need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies' cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.
BUFFALO, NY- February 29, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” Advanced age is the largest risk factor for many diseases and several types of cancer, including colorectal cancer (CRC). Senescent cells are known to accumulate with age in various tissues, where they can modulate the surrounding tissue microenvironment through their senescence associated secretory phenotype (SASP). Recently, researchers showed that there is an increased number of senescent cells in the colons of CRC patients and demonstrated that senescent fibroblasts and their SASP create microniches in the colon that are conducive to CRC onset and progression. However, the composition of the SASP is heterogenous and cell-specific, and the precise senescence profile of colon fibroblasts has not been well-defined. In this new study, to generate a SASP atlas of human colon fibroblasts, researchers Namita Ganesh Hattangady, Kelly Carter, Brett Maroni-Rana, Ting Wang, Jessica Lee Ayers, Ming Yu, and William M. Grady from Fred Hutchinson Cancer Center and the University of Washington School of Medicine induced senescence in primary human colon fibroblasts using various in vitro methods and assessed the resulting transcriptome. “[...] we utilized various relevant stressors to induce senescence in primary cultures of colon fibroblasts and perform RNA sequencing (RNASeq) to define an atlas of stressor-specific senescent profiles and a core senescent profile that is commonly regulated by all senescence inducers.” Using RNA Sequencing and further validation by quantitative RT-PCR and Luminex assays, the team define and validate a ‘core senescent profile' that might play a significant role in shaping the colon microenvironment. They also performed KEGG analysis and GO analyses to identify key pathways and biological processes that are differentially regulated in colon fibroblast senescence. These studies provide insights into potential driver proteins involved in senescence-associated diseases, like CRC, which may lead to therapies to improve overall health in the elderly and to prevent CRC. “Further studies will be needed to address the limitations of our study and to translate our understanding of the SASP and disease into clinical care.” DOI - https://doi.org/10.18632/aging.205577 Corresponding authors - William M. Grady - wgrady@fredhutch.org, and Ming Yu - myu@fredhutch.org Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205577 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, senescence associated secretory phenotype, SASP, colorectal cancer, cancer About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
In this week's episode we'll discuss extended follow-up from the ZUMA-5 trial of axicabtagene ciloleucel, or axi-cel. Then we'll learn about the role of platelets in binding and clearing senescent red blood cells. Finally, we'll hear about a new risk stratification strategy for lymphomas of the central nervous system, or CNS.
Today, I am blessed to have here with me Dr Nick Bitz. He is a Doctor of Naturopathic Medicine specialising in Ayurvedic medicine. He is presently the Senior Vice President of Product Development at Neurohacker Collective, a company that uses complex systems research to create revolutionary solutions for health and well-being. Dr Nick is interested in Ayurvedic medicine because of his health crisis. When he was a kid, he fell out of a tree, causing a chronic back issue. Not letting his health crisis pull him down, Dr Nick began his journey of self-care and healing. He dives into Buddhist meditation, yoga, and Ayurveda. Eventually, he landed on acupuncture, where he saw the light that he would live a life free of chronic pain. He uses all the tools he can to heal himself. Ultimately, Dr Nick moved to India and focused on Ayurvedic medicine. In this episode, Dr Nick Bitz talks about what cellular senescence is and why it is related to the reason why humans age. He also discusses keeping healthy cells and developing resilience. Aside from that, Dr Nick dives into why fasting is critical to reset our bodies. Tune in as we chat about cellular senescence, fasting, developing resilience, Qualia Resilience Supplement, and building immune health. Get Qualia products here: neurohacker.com/ketokamp Coupon Code: KETOKAMP (good for 15% off order) Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and heterogeneous form of cancer that affects thousands of individuals worldwide. The prognosis for HNSCC patients can vary greatly, depending on factors such as tumor stage and site. The tumor microenvironment (TME) plays a crucial role in tumorigenesis and disease progression, with cellular senescence being a key component. Senescent cells, characterized by cell-cycle arrest, have been shown to have both tumor-suppressive and tumor-promoting effects. However, the prognostic significance of senescence-related TME genes in HNSCC remains poorly understood. In a new study, researchers Young Chan Lee, Yonghyun Nam, Minjeong Kim, Su Il Kim, Jung-Woo Lee, Young-Gyu Eun, and Dokyoon Kim from Kyung Hee University, Kyung Hee University Hospital at Gangdong, and the University of Pennsylvania aimed to investigate the prognostic significance of senescence-related TME genes in HNSCC and their potential implications for immunotherapy response. They utilized data from The Cancer Genome Atlas (TCGA) to identify two distinct subtypes of HNSCC based on the expression of senescence-related TME genes. The team then constructed a risk model consisting of senescence-related TME core genes (STCGs) and validated its prognostic capability in independent cohorts. Their research paper was chosen as an Aging cover paper and published in Volume 16, Issue 2, entitled, “Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma.” Full blog - https://aging-us.org/2024/02/senescence-related-tme-genes-as-key-prognostic-predictors-in-hnscc/ Paper DOI - https://doi.org/10.18632/aging.205346 Corresponding authors - Young-Gyu Eun - ygeun@khu.ac.kr, and Dokyoon Kim - dokyoon.kim@pennmedicine.upenn.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205346 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, head and neck cancer, immunotherapy, microenvironment, single cell About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don't need Big Pharma to keep us feeling young―we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies' cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “Blue Zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity. Shermer and Greger discuss: • why we age and die • lifespan, vs. healthspan • longevity escape velocity • how to determine causality in aging science • nutrition fads • the anti-aging industry • Centenarians Diet • Mediterranean Diet • Okinawan Diet • Red, White, and Blue Zones • plant-based eating • exercise, sleep, stress • the Anti-Aging 8 • cholesterol and statins • vaccines • brain supplements • UV protection • alcohol • Alzheimer's • social ties, friendships, and marriage. A founding member and Fellow of the American College of Lifestyle Medicine, Michael Greger, MD, is a physician, New York Times bestselling author, and internationally recognized speaker on nutrition, food safety, and public health issues.
In this episode, we dive into the world of regenerative medicine. Dr. Gonzalez discusses the power of stem cells and NK cells, exploring how they work and their potential to bring about changes in the body. He shares stories of individuals who have experienced remarkable transformations through these treatments, including the host Dr. Axe. The conversation also delves into the latest research on using stem cells for conditions such as autism, cancer, orthopedic issues, and autoimmune diseases. We touch on the benefits of PRP and exosomes as well. Additionally, we address the challenges and pitfalls within the regenerative industry, highlighting what to avoid. Finally, we explore the different tiers and options available in the field of regenerative medicine, including bone marrow and fat treatments. Tune in for a deep dive into the fascinating world of regenerative medicine. 02:09 Overcoming a spinal infection. 03:55 Radical improvement with stem cells. 09:09 Regulating the immune response. 11:29 Stem cells and their benefits. 20:56 Improvements in quality of life. 21:44 Improvements in autistic kids. 27:46 Senescent cell removal. 29:12 NK cells and their impact. 32:54 Connection between NK cells and co-infections 36:08 NK cells and stem cells. 39:24 Cell communication and exosomes. 45:39 Unique cord lining stem cells. 46:07 Stem cell aging and replication. 50:30 Dr. Rafael's clinic and consultations. 54:26 Stem cell research and therapies. Discover the Nutrition, Lifestyle, and Fitness Plan that Works Best with Your Body with InsideTracker! Get 20% off at INSIDETRACKER.COM/AXE20 Get 15% OFF your first Leela Quantum Tech (LEELAQ.COM) order with code ANCIENT Get $200 OFF a Coldture cold immersion tub (Coldture.com) with code AXE. Guests Links: www.rehealth.com @rehealth.stemcells Follow @healthinstitute on Instagram! www.instagram.com/healthinstitute Join Our Newsletter! www.thehealthinstitute.com/wellness-weekly
If there is one thing that humanity has been striving for since its inception, is the pursuit of longevity. Today I'm with Chris Mirabile, Founder & CEO of NOVOS Labs who brings us one step closer to cracking the code of aging and longevity and offers fascinating insight into the intersection of health, performance, and longevity. We discuss how short-term health strategies may not always contribute positively to longevity, and the nine hallmarks of aging that NOVOS Labs aims to address. These include loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. Chris's interest in health began when he was 12 and evolved into a passion after he was cured of a brain tumor when he was 16. Chris has researched and integrated longevity practices and interventions into his life for more than ten years, has achieved a biological age 13.6 years younger than his chronological age, and according to epigenetic tests like DunedInPACE, is aging 31% slower biologically than chronologically. As we dive deeper into the realm of aging and anti-aging strategies, we bring ourselves one step closer to a future where longevity is not just a dream, but a reality. Chris Mirabile graduated from NYU Stern School of Business and later won their business plan competition with his startup company, Hotlist, a location-based social network that scaled to 220 million people's social plans. Chris has launched multiple successful technology ventures and has advised biotech startups and NYU Langone Hospital. Vist novoslabs.com and use code NAT5 to save. Thank you to our sponsors for making this episode possible: BiOptimizers: Use code bionat10 at magbreakthrough.com/bionat LMNT: Visit DrinkLMNT.com/NAT - no code needed Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Chris: Instagram: instagram.com/slowmyage/ Twitter: twitter.com/slowmyage Website: slowmyage.com What we discuss: (0:03:00) - The Short-Term Health vs. Longevity Dilemma (0:10:34) - Balancing Strategies for Longevity (0:19:29) - Aging and Anti-Aging Formulations (0:28:32) - Autophagy and Microbiome in Aging (0:39:26) - Understanding Senescent Cells-Safest Approach (0:53:55) - Comparing Different Aging Clocks Key takeaways: Aging and longevity are complex processes with numerous factors at play, such as loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. Senescent cells, while often perceived negatively due to their contribution to aging, can also play beneficial roles in certain contexts such as wound healing and limiting fibrosis. However, current senolytics can pose risks due to potential toxicity and lack of precision in targeting the right cells. While strategies such as severe caloric restriction or prolonged fasting can contribute to longevity, they may also have detrimental effects on short-term health and performance. It's crucial to strike a balance and consider the long-term implications of these health strategies. The ideal time to start implementing longevity strategies, like Novos, is around late 20s to early 30s.
Dr. Amit Sharma was awarded a Master's degree in Biomedical Sciences from Delhi University, India. He received his PhD in 2009 in Biotechnology from University of Pune for his work demonstrating microRNA regulation of cytokines invovled in allergic inflammation in mice models. Dr. Sharma's postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models. Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence affects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with translational focus. Newsletter sign up (new and exciting developments)https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join https://youtu.be/8QwvcRvsT_0 Over 321 books from 170 plus interviews over 5 yearshttps://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Amit Sharma Linkshttps://www.sens.org/about-us/team/https://youtu.be/AoRb1Z0XanMhttps://www.sens.org/our-research/https://www.linkedin.com/in/amit-sharma-1613b189/ Timestamps00:00 Dr. Amit Sharma00:45 Which path to achieve longevity/ healthspan02:40 integrated approach03:50 Typical week working on longevity07:20 Black swan events / SENS foundation08:30 Too high risk ideas09:09 Innovation brain / Elon Musk10:50 Dyslexia thinking in 3d and how Amit thinks12:40 Seeing opportunities14:20 Amit Sharma Leadership style16:00 Spinning off companies vs staying in pure research18:30 Mentorship, life events, inspiration and seeing longevity as the path for her21:00 Skills to be successful in longevity24:55 Project / moments at SENS that is awesome27:15 Longevity and Iron30:17 Visualizing senescence apoptosis32:30 Other uses / Cancer applications / USF34:40 Immune system not aware of eyes35:52 Blood brain barrier degradation with ate, NK cells, t cells36:47 T -cells, inflammation, and alzheimer's38:44 Crazy ideas for treating alzheimer's disease40:40 Cost to build an Amit Sharma center of research within SENS / Idea for Lisa43:00 Donating money to SENS / mito mouse45:00 Ancient infections hiding in genome47:35 Gut microbiome longevity Drosophila52:25 Mice / research / history of work56:30 Cell culture, senescence, mouse models creating new perspectives57:40 FanQ How do you know that the allogeneic CAR-NK cells won't cause Graft vs Host disease?1:00:01 FANQ How many possible senescent cell markers do you think there may be in senescent cells? Do you see being able to target say 70% of Senescent cells with just say 10 markers?1:03:50 FANQ How far do you think you are from an IND application?1:05:55 FANQ Do you have an orphan indication you might want to target first?1:06:50 Book recommendations1:10:00 Amit on never retiring1:10:30 What he needs help with
A Passion for Animal Wellness. Welcome to this week's episode of the Team Never Quit Podcast, where we explore the fascinating world of veterinary medicine and animal wellness. In today's episode, we are honored to have a distinguished guest, Dr. Terry Fossum, a world-renowned and board-certified veterinary surgeon. Dr. Fossum is a leading figure in the field of veterinary surgery, having earned international acclaim for her expertise. She is the author of a best-selling textbook on small animal surgery, a testament to her deep knowledge and commitment to advancing veterinary practices. With over 18,000 surgeries under her belt, Dr. Fossum has dedicated her career to the well-being of animals, striving to ensure that pets lead healthy and happy lives. As a respected authority in the veterinary world, Dr. Fossum has been invited to deliver over 1,000 lectures to veterinarians worldwide. Her insights have shaped the knowledge and skills of professionals across the globe. Her contributions extend beyond the operating room. Dr. Fossum's commitment to education and sharing her expertise has left an indelible mark on the veterinary community. - Purchase Dr. Fossums Pet Care products at drfossums.com & use code TEAMNEVERQUIT for 30% off! Products include: CBD (Great for Anxiety & Mobility) Topical product for scratching (w/ Oleander) Product for cognitive dysfunction in dogs COMING SOON: Really amazing, oral anti-itch product & a cardiac support product! In this episode you will hear: • In my world, I do soft tissue surgery. I don't even do orthopedic anymore. (9:54) • When I was at A&M, with the help of then governor Perry, we built a large laboratory practice facility. (11:06) • [Oleander] could be one of the most amazing natural compounds we have ever identified. (12:30) • Senescent cells are the reason that we age. I think we can slow it down. (13:50) • We do want to live longer and healthier. (13:47) • As the number of divisions that a cell has continues, eventually they start making mistakes. (14:07) • Some cells become senescent, which means they no longer divide. They sit in our body and secrete really inflammatory substances. (14:53) • If you give a chemotherapeutic to a person, you drive some cells into senescence. And those cells are no longer going to respond to the chemotherapeutic. (16:06) • Q: How much do you think it costs to get a drug approved through the FDA? A: 2 Billion Dollars [$2,000,000,000) (17:30) • When I hear that saying: “Dogs are man's best friend”, what I think of is that dogs really are man's best friend. (36:16) • [Marcus] A dog's love – Dog and God – that love that they show – unconditional – I wish I could love like that. (37:02) • Oleander and a couple of synolytics and I think we have a great product that we will all take. (60:07) • You can tell what kind of people people are by the way they treat their animals. (61:34) • [Marcus: My dog, Mr. Rigby, a service canine] Boy, he was my best friend, I loved him and he never said one word to me. (63:32) • Marcus: When I was a young man going to the SEAL teams, people weren't SEALS would make up all these grand stories about what it took to get through the program: They give you a puppy, and you have to raise him, and then you gotta kill him. I had to go through [my service dog] Mr. Rigby. And I was the one who had to put him down. I've never felt any kind of pain like that. (64:54)
References Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX Leukemia 2020. volume 34, pages 75–86 CELL 2006. Volume 126, Issue 3, Pages 503-514 Nat Cell Biol. 2019 Mar; 21(3): 397–407. Curr Opin Pharmacol. 2021 Apr; 57: 107–116. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Welcome to Thriving with Technology, the science-led podcast that helps you achieve mindful living in a digital world. August Brice is the founder of Tech Wellness and your host on this weekly adventure. We give you practical tools to limit your tech toxin exposure and prioritize your health without sacrificing technology. In each episode, we interview passionate leaders in the health and technology space who give you the tools to navigate and thrive within our technology-driven world. Our goal is to demystify the dangers of tech and bring you practical advice to protect yourself from EMFs, blue light, internet overuse, and how to recognize the signs of tech addiction. On today's show: This episode is FASCINATING (especially for all those science nerds out there like me). I came into this interview with a TON of questions and a desire to bust some myths about the ever-mysterious shungite as EMF protection. Here's what it is all about - Research shows that one of the mechanisms of damage from EMF's is oxidative stress that can result from the way the frequencies wreak havoc on cells, causing them to not function properly. EMF can disrupt the voltage gated ion channels on our cell membranes--causing them to not open and close as they should. This leads to a cascade effect of oxidative stress, which we all want to avoid. That's why antioxidants are of recommended by functional medicine to help mitigate the effects of this stress on our systems. There are many types of antioxidants, but C60 is one that has become very popular in the last few years. To be honest, for a long time I avoided C60, because I had seen it discussed in shungite literature as a special component of shungite - and as the research is very, very weak when it comes to the “EMF Protection” capabilities' of shungite I steered clear of anything having to do with it. However, then I met Ket Swartz - A scientist and inventor who spent who spent time investigating both the power of C60 and whether or not shunghite has C60 (otherwise known as fullerenes) and multiple patent holder who happened on to the power of the C60 molecule in an effort to curb the effects of radiation exposure from his lab. He became such a fan that he created his own C60 product and contributes to the C60.org website that provides education only on behalf of all C60 companies in an effort to separate the myth from reality by providing a source for all the research on the topic. He's tested several different Karelian shungite products for C60 and he shares his findings and helps us understand the confusion around fullerenes, C60 and shungite as well as explaining how c60 works. NOTE: This is not a recommendation or endorsement of this antioxidant, I just wanted to share with you all the insight I received around the many questions I had. Be Well! August Timestamps [00:04:11] Macular degeneration disappearance [00:08:04] Shungite and C60 research [00:10:22] Shungite and C60 clarification [00:14:05] Torsion energy and time technology [00:17:14] Electromagnetic radiation and protein damage [00:19:11] Remote plant growth stimulation [00:23:10] Real scientific evidence with C60 [00:26:01] C60's unique charge interactions [00:29:11] C60's effect on the body [00:36:28] Cellular regeneration and electromagnetic sensitivity [00:37:29] Hair growth and inflammation reduction [00:41:30] Senescent cells and aging [00:43:05] Athletic performance and C60 [00:47:19] The Goldilocks of oils [00:49:15] More on Shungite [00:53:38] Edible massage oil [00:55:17] Conflicting information about C60 [00:58:04] Gummy creation process [01:01:18] C60 and skin protection Links Mentioned Website: https://shopc60.com/ For more information, resources and videos visit TechWellness.com Memorable Quotes "And they basically gave one set of rats C60. The other set didn't. That's the control group. They hit it with a multiple dose of fatal radiation. All the C60 rats live, whereas the control group that didn't get it died." [00:03:15] – Ken Swartz "C60 is the only antioxidant you can take that will increase athletic performance.” [00:28:29] – Ken Swartz "Our body's designed to have one omega three for one omega six. Right now, people with all these seed oils, they're taking 20 omega sixes to two omega one omega threes. And that's super inflammatory. In fact, it's one of the leading causes of health problems in today's population." [00:46:46] – Ken Swartz
In this insightful episode of 'The Art of Aging Mindfully', we delve into the fascinating world of senescence, exploring the role of these 'Zombie Cells' in the aging process. Join your host, Jai Sugrim, as he uncovers the secrets of senescent cells, their function, and their impact on our health and longevity.We start by defining senescence and its contribution to aging and disease progression. Learn about the triggers for cellular senescence and understand how these 'dormant' cells can still have profound effects on our body.We then navigate through the promising field of senolytics, discussing both pharmaceutical and natural treatments designed to target these senescent cells. We explore cutting-edge research and the potential of these therapies to revolutionize our approach to age-related diseases.Finally, Jai shares practical and actionable lifestyle strategies that can help manage senescent cells. From dietary modifications to exercise and mindfulness practices, discover how these daily habits can influence your cellular health and overall well-being.Whether you're a health enthusiast seeking to deepen your understanding or someone interested in the scientific aspects of aging, this episode offers a comprehensive guide to one of the most exciting topics in the field of biology. Join us for a captivating journey into the heart of our cells!"Remember to leave a review and subscribe if you found this episode helpful. Your support helps us bring more of such enlightening content your way!Enjoy and Share the episode! To support The Art of Aging Mindfully Podcast go to patreon:The Art of Aging Mindfully Podcast PatreonThe Art of Aging Mindfully Podcast is sponsored by Viome, Acorn Biolabs and Whoop, your personal digital fitness tracker.To Harvest Your Own Stem Cells, for Future Use, with Acorn Biolabs:https://www.acorn.me/affiliate/the-art-of-aging-mindfullyTo test your full body and gut intelligence with Viome:http://viomehq.sjv.io/eKnAO1Use The $110 discount code: ARTOFAGINGOrder your whoop strap with Jai's Unique Link:https://join.whoop.com/376818To train with Jai, and learn about his yoga classes and massage therapy treatments:https://theartofagingmindfully.com/
Chile, we're going in-depth into cellular senescence and how targeting these senescent cells is an amazing anti-ageing strategy. Did you know that generally, all 37 trillion cells in the human body will replicate about 50 times before ending their life cycle? This natural aging process is one of the 12 hallmarks of aging but when we embrace the power of targeting Senescent cells, we can enhance our overall well-being, delay age-related diseases, and maintain a higher quality of life as we age. With the help of our expert guest, Dr.Nick Bitz, we're going to explore ways that we can promote healthy aging, improve longevity and nurture our health long-term. So, sis, grab your Baobab smoothie and get ready to learn:What cellular senescence is and how it can apply to you and your aging What rituals and habits you can include to slow down cellular senescenceWhat supplements you can add to your routine How you can incorporate strategies to target senescence cellAnd more about the future of health, aging and the human body. Dr. Nick Bitz is the Senior VP of Product Development at Neurohacker Collective and he specializes in nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. His insight and suggestions prove to be so worthwhile. Find out more about Neurohacker Collective products on their website, www.neurohacker.comSis, if you're ready to take on this amazing ageless journey, then check out my 8-week program, Staying Ageless. Master life-giving healthy rituals that leave you feeling & looking better than ever! To get started, sign up for your free 20 min call with me at www.therawgirl.com/services-5-1
Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body. Cellular senescence is the process by which cells permanently stop dividing but do not die off. These senescent cells linger inside the body and accumulate over time, affecting the healthy function of tissues and organs as we age. I'm joined by Dr. Nick Bitz, and we're diving into everything you need to know about senescent cells and cellular senescence. We discuss why our bodies need some senescent cells, and some of the lifestyle changes we can make to support the body's ability to clear senescent cells. Plus, we answer the question: How young is too young to be worried about your senescent cells? Dr. Nick Bitz is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. Thank you to our sponsors for making this episode possible: Add Neurohacker's Senolytic to your longevity routine by using code NATHALIE at neurohacker.com/nathalie LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Nick Bitz: Website: https://neurohacker.com/ Instagram: https://www.instagram.com/neurohacker/ Facebook: https://www.facebook.com/neurohackercollective LinkedIn: https://www.linkedin.com/in/nick-bitz-283a03b/ What we discuss: [00:04:18] Why our bodies need some senescent cells [00:11:34] How young is too young to be worried about your senescent cells? [00:19:18] Lifestyle changes to support the body's ability to clear senescent cells [00:30:43] Optimizing health throughout the entire body [00:40:53] Targeting different communities of senescent cells [00:47:21] The importance of intermittent fasting Key Takeaways: 40 years old is the age where it is especially important to start taking steps to prevent senescent cells from accumulating in the body and causing age-related diseases, inflammation, weakened immune system, and cell damage. Autophagy is the process by which cells break down and recycle their own components. Promoting autophagy can help reduce the formation of senescent cells, as it can help the body remove damaged cells and other debris that can accumulate and lead to cell senescence. Senescent cells can accumulate in different tissues and organs, such as the skin, heart, and lungs, and can disrupt normal function. Therefore, it is important to address senescent cells in all tissues and organs to ensure optimal health.
Imagine accurately determining the status of your skin's age to tell whether it is younger or older than your chronological age, and then use this technology to determine whether expensive anti-aging serums and creams are effective, or actually causing more harm than good. Amazing, right? This is precisely the technology Dr. Carolina Reis Oliveira and her fellow stem cell biologists at OneSkin created and you will find this interview fascinating on so many levels – I know I sure did! After creating their skin clock, the OneSkin team discovered peptide OS1, which targets senescent cells, one of the root mechanisms of aging, and is being shown in current studies to have a positive effect on hydration, firmness, elasticity, and the skin barrier. Listen as Dr. Reis explains the science and ongoing studies exploring the possible benefits of OS1 for the skin microbiome, hair loss, inflammation, and overall health.
Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence. Sponsored Message: Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Link to Articles & Images: https://bit.ly/42kjEen Show Notes: 00:25 Cellular senescence accelerates biologic ageing. 02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules. 02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue. 03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells. 05:45 Dysfunctional mitochondria influences glycolysis in cells. 06:15 Give your cells less fuel, glucose, for the proliferation of inflammation. 07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence. 08:00 Sirtuins can inhibit the formation of senescent cells. 08:55 Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia. 10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells. 12:00 Fat cells can become senescent. 13:00 Ketones (BHB) can help inhibit cellular senescence. 13:25 Optimized omega 3 to omega 6 ratio can help. 14:00 Exercise counters age-related accumulation of senescent cells. 14:40 Senescence within your immune cells is linked with cancer and poor response to infection.
My guest this week is Dr. Rand McClain of Regenerative and Sports Medicine. In this episode, Dr. Rand McClain and I discuss stem cells, epigenetics, blood sugar and regenerative medicine as a whole. Dr. Rand shares some patient stories of reversal of arthritis and even MS symptoms in people. We discuss the cutting edge modalities you may have been wondering about or even heard multiple contradictory viewpoints on and he sets the record straight. Though nutrition and wellness have been ingrained in Dr. Rand McClain since childhood, his journey to becoming a leader in alternative and progressive medical treatments has been anything but orthodox. From being the youngest senior account manager in Deloitte's history, to his stint as a professional boxer in Argentina, to being accepted to medical school at age 37 after being repeatedly told it was impossible, Dr. Rand has never been a fan of the “status quo”. Dr. Rand's patients (many of which are A-List celebrities and world-class athletes) come to his practice, Regenerative and Sports Medicine, in search of the innovative treatments he specializes in. From bioidentical hormone replacement therapy (BHRT), hyperbaric oxygen therapy to cryotherapy, Dr. Rand has dedicated the past 35 years to redefining what it means to be in optimal health. What is Discussed: [01:30] What is regenerative medicine?.. [03:50] Blood sugar and overall health… [06:30] Let's talk about epigenetics… [10:54] How does gene editing work?.. [17:20] It is not too late. What you can do to change your health now… [23:00] What is going on with the legality of stem cells and stem cell regulation?.. [25:09] Stem cell options… [29:00] Senescent cells, where is the sweet spot? [38:28] What is the legal status of expanding stem cells?.. [41:05] What can we use stem cells for?.. [44:00] Stem cells for healing concussions… [50:12] How to prepare the body for stem cells… [53:15] Cortisone, should you take it?.. [61:15] What are the three types of cells? [63:10] Using stem cells for chronic diseases.. [67:30] How old is too old to harvest your own stem cells?.. [68:50] Dr. Rand's book information... Favorite Quotes “These are all things we can all tease out in the lab using gene editing before we start testing on humans…” “Stem cells - these are more like a genie than anything else” Find More From Nathalie YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from guest: https://psrmed.com/ https://drrandmcclain.com/ https://www.facebook.com/DrRandMcClain https://www.instagram.com/dr.randmcclain/ https://www.linkedin.com/in/rand-mcclain/ https://twitter.com/dr_randmcclain About the Sponsors: BiOptimizers: For Sleep Breakthrough use code BIONAT10 at checkout to save 10% at sleepbreakthrough.com/bionat Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Profound Health: You can purchase Primeadine at https://oxfordhealthspan.com/products/best-spermidine-supplement and use promo code BIONAT15 to save 15% of your first order.
Today, I am blessed to have here with me Dr Nick Bitz. He is a Doctor of Naturopathic Medicine specialising in Ayurvedic medicine. He is presently the Senior Vice President of Product Development at Neurohacker Collective, a company that uses complex systems research to create revolutionary solutions for health and well-being.
Everyone wants to slow down the signs of aging, but very few people are going about it the right way. The negative aspects of aging are one of the most ubiquitous challenges to quality of life. However, one thing is for sure: scientists believe that a big part of the reason we experience aging the way we do is because of stressed or worn-out cells called senescent cells. Senolytics is a term used to describe ingredients shown to help decrease these damaging senescent cells. My guest on this show - Gregory Kelly - has helped to develop several rare and powerful compounds that have scientifically shown senolytic activity, and which collectively cover a broader range of mechanisms than existing senolytic supplements on the market. His protocol, which we discuss on this show, involves a two-day rejuvenation regimen that he suggests using every month. Intermittent short-duration dosing is the most common way that senolytics are used in studies, and data suggests that it can take weeks for senescent cells to re-accumulate in the body, which is why Greg recommends this approach. Greg's compound is called "Senolytic" and made by my friends at Neurohacker Collective. For the full episode page and shownotes, visit: https://bengreenfieldlife.com/senolytic Episode sponsors: Organifi (Red): Recharge your mind and body with a delicious superfood berry blend of premium, organic superfoods that contain potent adaptogens, antioxidants, and a clinical dose of cordyceps. Increase energy and boost nitric oxide levels with zero caffeine and only 2 grams of sugar. Go to organifi.com/Ben for 20% off your order. Seed: If you're taking supplements, but not a probiotic, you might be overlooking your gut—which affects your whole-body health. If you want to add a probiotic + prebiotic to your daily routine, use code BEN15 at seed.com/ben to redeem 15% off your first month of Seed's Daily Synbiotic. Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go Joovv.com/ben and apply code BEN. Element Health CBD: Full-spectrum CBD and by far the most potent stuff on the market. If you're dealing with sleeping problems, anxiety, or stress, you got to try it. It's been a game changer for me. Go to elementhealthsupply.com/ben and use code BEN15 for 15% off your entire order. Boundless Parenting Book: Everything you need to know about family, parenting, and raising healthy, resilient, free-thinking and impactful children. Go to boundlessparentingbook.com and pre-order your copy now. BGL CAREERS: Check out our open positions at BenGreenfieldLife.com/Careers. Shine Sedona: Join my family and me in Sedona Arizona from March 10-12, 2023 at an amazing event hosted by SHINE. I'll be giving a keynote talk on breathwork and biohacking, and hosting a VIP Greenfield-style home-cooked dinner prepared by my family. For tickets to the Shine Event where I'll be a keynote speaker visit bengreenfieldlife.com/shinesedona. To book your spot for our VIP dinner visit bengreenfieldspeaking.com/sedona-dinner.
This episode is brought to you by Rupa Health and Athletic Greens. To understand and combat rapid aging, we need to understand what causes aging, chronic diseases, and decline. We call these things the hallmarks of aging—the underlying common pathways or mechanisms of aging. Each hallmark is influenced by the others and affected by various imbalances—too much or too little of certain inputs that can negatively impact the expression and progression of the hallmark. Understanding those interactions and weblike connections is the key to solving the puzzle of aging. In today's episode of my series I'm calling Health Bites, I dive into the 10 distinct hallmarks of aging and how to address them. What I've discovered has blown my mind and changed the way I approach my own health and the health of my patients. I've compiled it all into a new book called Young Forever, which comes out on February 21, 2023. Learn more and preorder the book at youngforeverbook.com.This episode is brought to you by Rupa Health and Athletic Greens.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Here are more details from our interview (audio version / Apple Subscriber version):Disrupted hormonal and nutrient signaling (8:08 / 4:40) DNA damage and mutations (17:38 / 14:12) Telomere shortening (19:19 / 15:52) Damaged proteins (20:32 / 17:04) Epigenetic damage (22:56 / 19:29) Senescent cells (otherwise known as zombie cells) (25:11 / 21:43) Depleted energy and mitochondrial decline (26:44 / 23:17) The link between gut health and longevity (28:33 / 25:07) Stem cell exhaustion (30:38 / 27:14) Inflammaging and dysfunction in immune functioning (32:00 / 28:32) Hosted on Acast. See acast.com/privacy for more information.
Today, I am blessed to have here with me Dr. Gonzalez. He obtained his Ph. D and BS from the University of California, Irvine where he studied, and his thesis addressed interactions of the immune system following spinal cord injury. In addition to his expertise in degenerative disorders involving the spinal cord, he has extensive experience in stem cell culture and biology from various sources. He has extensive knowledge in all aspects of cell biology and health where he teaches worldwide on regenerative medicine and maintaining immune health. This episode originally aired in August 2021. Dr. Gonzalez is responsible for the development of clinical stem cell applications for several disease/trauma states. He leads 4 different investigational new drug applications with patented stem cell technology. Additionally, he works on the clinical development of immune based therapies using natural killer cells. He had led a reference laboratory in testing various regenerative medicine products. Dr Gonzalez has been in the regenerative medicine field for more than 18 years and has several scientific publications. He has taught, spoken and led many conferences nationwide in the regenerative medicine sector. In this episode, Dr. Gonzalez reveals the inspiration behind his career in the stem cell space. We speak about why cell therapeutics is known as the wild west and the amount of FDA testing Dr. Gonzalez goes through to ensure safe products. Then, Dr. Gonzalez dives into what exactly stem cells are and how they can improve the natural processes that are already occurring in your body. Tune in as we talk about the importance of fasting, turning your life around after an autoimmune diagnosis, and who should consider getting cell therapeutics. Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S Dr Phillips CBD Oil & Keto Fruit Chews. Visit www.drphillipscbd.com Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:45] Why Dr. Gonzalez Started In The Stem Cell Space At college, Dr. Gonzalez studied embryonic stem cell research in spinal cord injuries. He loves to understand and study cells. Stem cells have properties that can heal the body. Plus, Dr. Gonzalez believes that stem cells can work against aging. In fact, stem cells are made naturally inside our body. [08:00] The Wild West of Cell Therapeutics & FDA Testing Any form of cell therapeutics is like the wild west. When you submit for the cells to have a Chemical Manufacturing Composition, it takes years. Gonzalez got his first clinical study approved in 2019 with the FDA. Essentially, the FDA boils down to the amount of testing. They are always ensuring that the product is safe. [13:05] How Stem Cells Can Improve The Natural Processes In Your Body Pompa and Dr. Gonzalez have been looking at using stem cells to control the inflammatory state and increase blood flow. We need increased blood flow because you'll notice brain fog and a loss of energy without it. The natural property of our body is actually to increase blood flow any way that it can. The cells in your body have three fates: Natural cell turnover Necrosis Senescence When our cells stop dividing, they start occupying space and cause havoc. These cells can cause wrinkles and gray hair. There's a cell type in our body that is a natural killer. These cells have three jobs: Remove a cancer cell Pick up viral load Wipe out senescence cells If you don't have immune health, you essentially have nothing. Every single disease has an immune component to it. [22:10] The Critical Role Fasting Plays In Longevity Aging is an issue of cell growth. If you consume food incorrectly, your body has to process all that. When you keep dividing cells, you are causing senescence. One proven lifestyle change for longevity is fasting. Also, diet is important because you force your body to remove the toxins in your body. [26:00] Transform Your Health With ReHealth's Cell Therapeutics Learn about ReHealth here: https://rehealth.com/ Register at the website, and they will contact you. The consultation is completely free. Depending on what you are looking to achieve will determine what type of therapeutics you should consider. Mesenchymal Stem Cell Therapy can help with the aging process. [30:30] How To Start Getting Your Life Back After An Autoimmune Diagnosis First and foremost, Dr. Gonzalez likes to discuss diet. If you are taking a bunch of meds, then you are not going to get better. Stem cells will give you a temporary effect unless you are doing all the key lifestyle components. Think about your goal. Gonzalez doesn't help people who are smoking. Stem cells will simply be a Band-Aid. Overall, stop smoking, start fasting, and fix your diet. [33:00] How Frequently You Should Consider Working With ReHealth's Cell Therapeutics How often you will need cell therapeutics will depend on your goals and your situation. Some people will have one session and feel great for the next five or six years. Most people will get therapeutics every six months or every year. The effect of stem cells initially is far greater than the sequential effects. [42:30] The Type of Person That Should Seriously Consider Cell Therapeutics If you have immune issues, you need cell therapeutics. Also, if you've tried everything else, then you should try cell therapeutics. Sadly, doctors will want to hand you a pill. If you are going to go see someone, find someone who knows integrative medicine. If you have any questions, Dr. Gonzalez wants to answer them! Email: Rgonzalez@TheBioBox.com AND MUCH MORE! Resources from this episode: Check out ReHealth: https://rehealth.com/ Email: Rgonzalez@TheBioBox.com Follow ReHealth Instagram: https://www.instagram.com/rehealth.stemcells/ Facebook: https://www.facebook.com/rehealth.stemcells Twitter: https://twitter.com/Rehealth_ Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a WatchKeto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S Dr Phillips CBD Oil & Keto Fruit Chews. Visit www.drphillipscbd.com Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
FullyVital Hair Wellness - Are you interested in getting thicker, fuller and longer hair using natural ingredients? Make sure to check out https://fullyvital.com to get the natural products that stimulate hair follicles in 4 unique ways. Use code ANTIAGINGHACKS to get 15% off your first order. Dr. Nick Bitz is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. Get 15% off all Neurohacker products using the code ANTIAGINGHACKS Here are the items we discuss: 2:40 Dr Nick & How He Got Into Health & Wellness 06:10 How Dr Nick Brings Naturopathic Principles Into Products 08:00 What Are The Hallmarks Of Aging? 10:15 What Is Cellular Senescence As A Hallmark Of Aging? 13:05 Do Senescent Cells Harm Surrounding Tissues Or Also Tissues Far Away? 14:30 How Do Senescent Cells Survive Despite Your Body Trying To Get Rid Of Them? 17:20 Can We Target SCAP Networks To Disrupt Senescent Cells? 19:40 Why Use A Natural Approach For Senolytics? 26:00 Is A Systemic Or A Local Approach Better For Senolytics? 27:55 How Did Neurohacker Create This Senolytics Supplement? 29:00 At What Age Should People Start Using Senolytics? 31:00 How Often Should People Use Senolytics? 31:45 Is There A Test To Identify Senescent Cell Burden? 34:40 What Lifestyle Factors Can Help Cellular Senescence? 43:15 Where Can People Get The Neurohacker Senolytic and Other Products?
Healthy aging isn't just about slowing down the aging process. You also want to age powerfully and create vibrant health as you move into your 60s, 70s, and beyond. In this episode, JJ talks with James Schmachtenberger, co-founder and CEO of Neurohacker® Collective, a company focused on making groundbreaking products for health and well-being through complex systems science. Listen up as James defines what senescent cells are (and why cellular senescence holds the key for healthier aging), why longevity starts on the cellular level, how “health span” can help you age better, the correlation between joint pain and senescent cells, and how intermittent fasting and autophagy impact aging. You'll also learn why you may need supplements to be healthy, why toxins and stress can accelerate aging, the key between mitochondrial health and longevity, why supporting NAD metabolism is a key part of healthy aging, the connection between aging and muscle, the best type of exercise, and why our food today lacks the nutrients it had 100 years ago. It's never too early to focus on the aging process. In this information-packed episode, you'll learn the top tools and strategies to support longevity and age powerfully.
Episode Highlights With Dr. Nick BitzWhat to understand about aging and the multiple theories of what contributesWhy aging might be a slowed ability to adaptThe three main theories of aging and how understanding them can help you slow itWhat to look at and test as a baseline to determine agingWhat the nine hallmarks of aging are: telomeres, DNA mutations, epigenetic changes, senescent cells, etcCellular senescence: the process by which cells ageCompounds that can help improve the body's ability to deal with senescent cellsHealthspan vs lifespanHow fasting comes into play with aging and senescent cellsWhy exercise battles all aspects of aging (especially strength training)How early morning sunlight impacts hormones, sleep, and agingInteresting research around chlorophyll and agingThe importance of leucine and how to get itThings we are doing that are speeding aging (some might surprise you)What senolytics are and how to dose them (Quercetin, Fisitin, etc)Why senolytics in large doses every couple of months can be beneficialResources We MentionNeurohackerCan Intermittent Fasting (Skipping Meals) Make You Healthier?The Power of Now: A Guide to Spiritual Enlightenment by Eckhart TolleGrace and Grit: Spirituality and Healing in the Life and Death of Treya Killam Wilber by Ken Wilber
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