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BUFFALO, NY — June 5, 2026 — A new #review was #published in Volume 18 of Aging on May 15, 2026, titled “Blue period – features of senescence 30 years after beta-galactosidase.” The review was led by first author Chisaka Kuehnemann and corresponding author Christopher D. Wiley from Tufts University. Cellular senescence has emerged as one of the most important biological processes linked to aging and age-related disease. Senescent cells stop dividing in response to stress or damage, yet they remain metabolically active and release a variety of signaling molecules that can influence surrounding tissues. Over the past three decades, evidence has increasingly shown that the accumulation of these cells contributes to chronic inflammation, tissue dysfunction, and many degenerative conditions associated with aging. In this review, the authors examine how the field has evolved since the landmark discovery of senescence-associated beta-galactosidase (SA-β-gal) in 1995. That finding provided one of the first practical methods for identifying senescent cells and helped establish that these cells accumulate in aging tissues. Since then, researchers have identified numerous additional characteristics of senescence and developed new approaches to study their role in health and disease. The review highlights several major features now recognized as hallmarks of senescent cells. These include stable proliferative arrest, increased lysosomal activity, secretion of inflammatory and signaling molecules collectively known as the senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, alterations in nuclear architecture, accumulation of metals and lipofuscin, and enhanced survival despite exposure to cellular stress. Full press release - https://aging-us.net/2026/06/05/thirty-years-after-the-discovery-of-sa-%ce%b2-gal-researchers-revisit-the-hallmarks-of-cellular-senescence/ DOI - https://doi.org/10.18632/aging.206380 Corresponding author - Christopher D. Wiley - christopher.wiley@tufts.edu Abstract video - https://www.youtube.com/watch?v=lfMPJF6No7M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206380 Keywords - aging, senescence, biomarkers, SASP, cell death To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
The Menopause Mastery Show | The Hidden Shift In Midlife: Hormone Decline, Muscle Loss, and Healthy Aging During Menopause | Episode 281 with Jerry Mixon, MD
BUFFALO, NY — June 3, 2026 — A new #research paper was #published in Volume 18 of Aging-US on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.” The study was led by first author Michael Kamal from the Department of Kinesiology at McMaster University and corresponding author Gianni Parise from the same university. As people age, skeletal muscle gradually loses strength, size, and regenerative capacity. Scientists have increasingly linked these changes to cellular senescence—a state in which damaged cells permanently stop dividing but remain metabolically active. These senescent cells release a complex mixture of signaling molecules known as the senescence-associated secretory phenotype (SASP), which can influence neighboring cells and contribute to tissue dysfunction. In this study, the researchers investigated whether extracellular vesicles (EVs)—tiny membrane-bound particles released by cells—play a role in this process. Specifically, they examined EVs released by senescent muscle precursor cells, known as myoblasts, and analyzed the microRNAs (miRNAs) carried within these vesicles. The team found that senescent myoblasts released factors that impaired normal muscle cell development. When healthy muscle cells were exposed to signals from senescent cells, the resulting muscle fibers became significantly smaller and displayed increased expression of genes associated with cellular stress and senescence. Further analysis revealed that EVs released by senescent myoblasts carried a distinct set of miRNAs. The researchers identified 22 significantly altered miRNAs, including several previously linked to cellular senescence, such as miR-34a, miR-34b, miR-34c, and miR-22. The study also identified miR-301a-3p as a potentially novel senescence-associated miRNA. Full press release - https://aging-us.net/2026/06/03/senescent-muscle-cells-send-molecular-messages-that-may-contribute-to-age-related-muscle-decline/ DOI - https://doi.org/10.18632/aging.206379 Corresponding author - Gianni Parise - pariseg@mcmaster.ca Abstract video - https://www.youtube.com/watch?v=HKBbraYg8ew Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206379 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, extracellular vesicles, myoblasts, miRNA, multi-omics To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
The Menopause Mastery Show | The Hidden Shift In Midlife: Hormone Decline, Muscle Loss, and Healthy Aging During Menopause | Episode 281 with Jerry Mixon, MD
The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.What's Discussed:(01:06) Why skin needs autophagy more than almost any other organ(03:07) The cells on your face that may be older than your car(04:25) The 2013 paper that linked autophagy failure to dermatitis(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis(18:38) The 2019 Drexel rapamycin trial that proved this works in humans(23:22) The 2024 spermidine study that changes how we think about autophagy(29:51) Why your skin barrier collapses without this one moleculeResources Mentioned:Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
BUFFALO, NY — May 15, 2026 — A new #review was #published in Volume 18 of Aging-US on May 4, 2026, titled “Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions.” The study was led by first author Jian Deng and corresponding author Dong Yang from the Department of Targeting Therapy and Immunology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. In this comprehensive review, the authors examine how cellular senescence contributes to aging and age-related disease across multiple organ systems, while also highlighting the emerging complexity and functional diversity of senescent cell populations. Traditionally, senescent cells have been viewed primarily as harmful byproducts of aging, characterized by irreversible cell-cycle arrest and chronic inflammatory signaling. However, growing evidence suggests that some senescent cells also play beneficial physiological roles in tissue repair, embryonic development, and maintenance of tissue homeostasis. The review outlines how senescence develops in major tissues including the liver, lungs, kidneys, heart, adipose tissue, brain, and skin. Across these organs, aging-related cellular dysfunction is driven by a combination of oxidative stress, mitochondrial dysfunction, DNA damage, chronic inflammation, metabolic stress, telomere shortening, and environmental insults such as ultraviolet radiation and pollution. The authors describe how senescent cells accumulate in highly specialized cell populations—including hepatocytes, endothelial cells, fibroblasts, macrophages, astrocytes, and epithelial cells—where they can disrupt normal tissue architecture and promote chronic disease progression. Importantly, the article emphasizes that senescent cells are highly heterogeneous and should not be treated as a uniform population. Depending on the tissue context and biological environment, senescent cells may exert either protective or harmful effects. For example, certain senescent cells may help limit fibrosis or support wound healing, whereas others drive chronic inflammation, metabolic dysfunction, tissue degeneration, and cancer progression. This growing recognition of functional heterogeneity has prompted a major shift in anti-aging research away from indiscriminate elimination of senescent cells toward more selective and precision-based therapeutic strategies. “Based on these insights, this review summarizes the induction mechanisms of cellular senescence and the subsequent evolution of their functional phenotypes across diverse tissues.” Full press release - https://www.aging-us.com/news-room/precision-anti-aging-strategies-aim-to-target-harmful-senescent-cells-while-preserving-beneficial-ones Paper DOI - https://doi.org/10.18632/aging.206375 Corresponding author - Dong Yang – yangdong@wchscu.cn Abstract video - https://www.youtube.com/watch?v=HkJRwF8mp4A Keywords - cellular senescence, aging mechanisms, functional heterogeneity, precision anti-aging To learn more about the journal, please visit www.Aging-US.com and connect with us on social media at: Bluesky - bsky.app/profile/aging-us.bsky.social ResearchGate - www.researchgate.net/journal/Aging-1945-4589 X - twitter.com/AgingJrnl Facebook - www.facebook.com/AgingUS/ Instagram - www.instagram.com/agingjrnl/ LinkedIn - www.linkedin.com/company/aging/ Reddit - www.reddit.com/user/AgingUS/ Pinterest - www.pinterest.com/AgingUS/ YouTube - www.youtube.com/@Aging-US Spotify - open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells.Dr. Amit Sharma leads the senescence immunology group at the Lifespan Research Institute, where his lab studies how natural killer cells and gamma delta T cells interact with senescent cells — and how that relationship breaks down with age. In this conversation, we explore the biology of immune surveillance of senescence, why it fails as we get older, and what his lab is doing to restore and enhance it. We also discuss the iron-ferroptosis connection, next-generation senolytics, and what the next decade might bring for senotherapy.
Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.What's Discussed:(5:07) What the clinical data actually says about topical niacinamide(7:21) Why most niacinamide products on your shelf are underdosed(8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor(9:03) Niacinamide is a brightening agent, not an NAD+ booster(10:15) Why NMN can't cross the skin barrier alone(11:19) CD38 and blocking the enzyme that destroys NAD+(13:03) NAD+ alone is potential energy, not usable energy(13:45) Liposomal encapsulation and how real precursors get into the skin(17:02) The five mitochondrial pathways your skin actually needs(18:53) Senescent cells and the next telomeres conversation(25:17) Why NAD Apex targets NAD+ in three dimensions(26:39) Lifestyle strategies: fasting and the AMPK pathway(28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting(30:37) The fun fact behind why 16:8 fasting became the standard(33:02) HIIT and its compounding effect on baseline NAD+(34:51) Sleep is an NAD+ dependent repair session, not just rest(39:15) Your skin does 8x more renewal at night(41:38) Sun protection as an NAD+ strategy(44:49) Why you should expose your back more than your face(45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis(50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality(52:49) The perimenopause problem no one is talking about(56:29) Why niacinamide creates homework for the body(1:01:46) You recycle more NAD+ daily than you can ever supplement(1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+(1:05:35) Mitophagy, autophagy, and the role of spermidine(1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter(1:07:46) Fermented resveratrol and activating SIRT1Check out resources mentioned:Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the DeclineCheck out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy ConnectionSleep is Skincare episode: How Timing Unlocks Your Body's Best Skincare RepairFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.comInstagram: @young_goose_skincareVampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes
Stephen Thomas explores the science of ageing, focusing on inflammaging, senescent cells, and the importance of sleep regularity. Discover how these factors influence longevity and practical strategies to optimise health. takeawaysChronic low-grade inflammation accelerates ageing and impairs recovery.Senescent cells, or zombie cells, contribute to systemic inflammation and ageing.Sleep regularity is more crucial than duration for health and longevity.Managing inflammation and supporting cellular clearance are key to healthy ageing.
Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.Ready to nerd out in this with us?Let's dive in!What's Discussed:(4:00) The number that changes how you think about skin aging.(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.(8:18) The three enzyme families consuming your NAD+ as a substrate.(8:23) Sirtuins: the police of your cells and what they cost you.(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.(11:16) CD38: the NAD+ Pac-Man that gets worse with age.(15:10) The five-fold decline: what the 2012 tissue study actually found.(16:15) CD38 and the zombie cell feedback loop driving the decline.(19:39) What the depletion actually looks like in the mirror.(28:04) Why NAD+ decline is reversible & supplementation deep dive.(28:41) NMN: how it works and what the studies actually show.(31:50) NR: the most clinically studied precursor and who it's best for.(33:27) Niacin: the $5 option and why most people can't tolerate it.(38:14) Why timing your NAD+ to your circadian rhythm matters.(38:35) TMG and methylation: what to stack and the two-to-one ratio.Learn more about NAD from our previous podcasts and videos:Previous NAD YouTube Videos:NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0 The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XM Previous NAD Podcasts:NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123 The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462 The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098 Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945 Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344 Research Studies Mentioned: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357 CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7 Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3 Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/ Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1 Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7 Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% offBody Cream: Head to younggoose.com/products/youth-body-cream for 20% off
The research and real talk keep rolling in! Join Jenny and John yet again as they dive into some new revelations on vitamin D, Alzheimer's disease, and ultra-processed foods. Then, John brings the heat with an enthralling round of “Real Talk? Or Bro-Science?”Guest Name/ Guest Company / Guest or Company websiteJohn Bauer, Lionel UniversityInterview Date11/20/25Episode Title and Subtitle (i.e. Ep.0: Meet Your Hosts, Meet your co-hosts Jenny Scott and Dan Duran!)Research & Real Talk Episode 20 with GUEST John Bauer (he's baaaack!!)Episode Description- For website and podcast platformsThe research and real talk keep rolling in! Join Jenny and John yet again as they dive into some new revelations on vitamin D, Alzheimer's disease, and ultra-processed foods. Then, John brings the heat with an enthralling round of “Real Talk? Or Bro-Science?”Notes: (Links, websites, references etc) for show notesLighting Fitness Facts1. Which Fat-soluble vitamin is being researched for its anti-aging properties on a DNA level?A: Vitamin D!A new review out of Augusta University in the US is shedding light on how vitamin D—the so-called “sunshine vitamin”—may do more than just build strong bones. Researchers found that taking 2,000 IU of vitamin D daily helped preserve telomeres, the protective caps at the ends of our chromosomes that act like the plastic tips on shoelaces, keeping our DNA from fraying each time cells divide. Shorter telomeres are tied to aging and diseases like cancer and heart disease, so keeping them intact could mean healthier aging.In a five-year study of more than 1,000 adults, those who took vitamin D maintained their telomeres by about 140 base pairs more than those on a placebo—potentially slowing cellular aging. Scientists think vitamin D's anti-inflammatory effects may be key here, since inflammation accelerates telomere damage.That said, researchers caution that we still don't know the perfect dosage or whether longer telomeres always equal better health. The takeaway? Vitamin D might be one helpful piece of the healthy aging puzzle, but the best telomere protection still comes from the basics—good nutrition, regular exercise, quality sleep, and managing stress.2. As it relates to the diet, what are researchers homing in on as a primary cause of chronic systemic inflammation possibly leading to chronic health issues?A: high ultra-processed food consumptionNew research from Florida Atlantic University is sounding the alarm on ultra-processed foods—things like chips, soda, frozen meals, and processed meats that make up nearly 60% of the average adult's calories in the U.S. and almost 70% of kids' diets. These foods are packed with additives, low in nutrients, and designed to keep you eating more. The study found that people who consumed the highest amounts of ultra-processed foods had significantly higher levels of high-sensitivity C-reactive protein, or hs-CRP—a key marker of inflammation and a strong predictor of heart disease.Researchers analyzed data from over 9,000 adults across the U.S. and discovered that those getting 60 to 79% of their calories from ultra-processed foods had about an 11% higher likelihood of elevated inflammation compared to people eating the least. Even moderate consumers saw higher risk. The link was especially strong among people aged 50 to 59, those with obesity, and smokers.Inflammation is at the root of many chronic diseases—from heart problems to cancer—and the study's authors say this growing reliance on ultra-processed foods could be playing a major role. They even compare the situation to early warnings about tobacco use, predicting that it may take time and policy change before the food industry shifts. For now, the takeaway is clear: the closer your food is to its natural form—fruits, vegetables, lean proteins, and whole grains—the better for your long-term health.3. Alzheimer's research is constantly advancing and scientists think they have identified something that may be contributing to the development and progression of the disease. What do you think that may be? HINT- it is the buildup of something that is causing issues.A: Fat in the brain!Researchers at Purdue University have uncovered a surprising new clue in the fight against Alzheimer's disease—fat buildup inside the brain's immune cells may be a key driver of the disease's progression. Published in the journal Immunity, the study reveals that microglia, the brain's cleanup crew responsible for clearing toxic proteins like amyloid beta, become overloaded with fat and lose their ability to protect the brain.The team found that these fat-stuffed microglia, clustered around amyloid plaques, clear about 40% less amyloid than healthy cells. The culprit appears to be an enzyme called DGAT2, which gets stuck in overdrive and turns useful fatty acids into stored fat, clogging the microglia. When researchers blocked or degraded this enzyme in animal models, the microglia regained their function and began clearing out harmful debris again—restoring the brain's balance.This discovery marks a shift from the traditional focus on protein plaques and tangles to what scientists are calling a “lipid model” of Alzheimer's, where the buildup of certain fats—not just misfolded proteins—plays a central role in neurodegeneration. The findings open the door to a new class of therapies that target fat metabolism in the brain, potentially helping immune cells fight back against Alzheimer's and related diseases.References:1. Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong. Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. The American Journal of Clinical Nutrition, 2025; 122 (1): 39 DOI: 10.1016/j.ajcnut.2025.05.0032. Kevin Sajan, Nishi Anthireddy, Alexandra Matarazzo, Caio Furtado, Charles H. Hennekens, Allison Ferris. Ultra-processed foods and increased high sensitivity C-reactive protein. The American Journal of Medicine, 2025; DOI: 10.1016/j.amjmed.2025.08.0163. Salt, Sugar, Fat by Micahel Moss4. Priya Prakash, Palak Manchanda, Evi Paouri, Kanchan Bisht, Kaushik Sharma, Jitika Rajpoot, Victoria Wendt, Ahad Hossain, Prageeth R. Wijewardhane, Caitlin E. Randolph, Yihao Chen, Sarah Stanko, Nadia Gasmi, Anxhela Gjojdeshi, Sophie Card, Jonathan Fine, Krupal P. Jethava, Matthew G. Clark, Bin Dong, Seohee Ma, Alexis Crockett, Elizabeth A. Thayer, Marlo Nicolas, Ryann Davis, Dhruv Hardikar, Daniela Allende, Richard A. Prayson, Chi Zhang, Dimitrios Davalos, Gaurav Chopra. Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease. Immunity, 2025; 58 (6): 1536 DOI: 10.1016/j.immuni.2025.04.0295. Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela C. Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow, Ben A. Barres. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature, 2021; 599 (7883): 102 DOI: 10.1038/s41586-021-03960-y6. China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, Faith R. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. Sai Chaluvadi, Shirley L. Zhang, Ananth R. Srinivasan, F. C. Bennett, Amita Sehgal, Peter D. Adams, Gaurav Chopra, Nancy M. Bonini. Senescent glia link mitochondrial dysfunction and lipid accumulation. Nature, 2024; 630 (8016): 475 DOI: 10.1038/s41586-024-07516-8
Dr. Jerry Mixon on Longevity Medicine: Hormones, Body Fat, Muscle, and Senescent Cells Dr. Jerry Mixon describes “longevity medicine” as treating aging—the progressive loss of capacity—as a medical problem focused on healthspan, not vanity. He shares that at 78 he has maintained a global hormone balance targeted to a healthy 25-year-old range for 31 years, enabling significant strength and endurance gains compared with age 50, and argues more older men should live energetic lives. Mixon emphasizes reducing excess body fat as a priority because fat acts as an inflammatory gland linked to chronic disease, while muscle acts as a healing gland producing beneficial proteins; he advocates building muscle and managing blood sugar/insulin resistance. He explains mitochondrial fragility, senescent “zombie” cells, and immune-system decline, discusses using senolytics such as dasatinib plus quercetin, and describes developing testing to measure senescent T-cell load. The conversation also covers clinic protocols, lifestyle micro-bursts of exercise, family priorities, and aligning healthcare incentives toward prevention. 00:00 Rewriting Old Age 01:46 Longevity Medicine Defined 03:24 Aging as Disease 05:05 How We Peak and Decline 06:15 What Aging Really Is 08:24 From 50 to 78 11:38 Mindset and Metrics 14:52 Start With Getting Lean 17:13 Fat vs Muscle Signals 18:56 Hormones Back to 25 20:26 Testosterone Myths 24:07 Risks and Screening 25:54 Inside the Clinic Process 29:00 Fat Inflammation Cascade 33:20 Insulin Resistance Explained 36:32 GLP-1s and Muscle 37:45 Mitochondria 101 41:14 Senescent Cell Zombies 42:41 Autophagy and Immune Cleanup 44:31 Immune System Senescence 46:10 Hormones and Senescent Load 48:54 Clearing Senescent Cells 50:33 Lifestyle Levers Exercise 53:21 Senolytics and Measuring SASP 56:54 Testing Immune Senescence 58:29 COVID and Aging Immunity 01:01:17 Personal Results and Routine 01:08:26 Family Legacy and Purpose 01:12:54 Reforming Healthcare Incentives 01:19:42 Wrap Up and Disclaimer
BUFFALO, NY — March 10, 2026 — A new #research paper was #published in Volume 18 of Aging-US on March 3, 2026, titled “P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts.” Led by Shan Zhu — with corresponding author Yan Y Sanders from the Department of Biomedical and Translational Sciences, Eastern Virginia Medical School (Macon & Joan Brock Virginia Health Sciences at Old Dominion University) — the study examines how the stress-activated kinase p38 MAPK contributes to persistent profibrotic gene expression in replicative (passage-driven) senescence of human lung fibroblasts and in primary fibroblasts from patients with idiopathic pulmonary fibrosis (IPF). Using IMR90 lung fibroblasts at low and high population-doubling levels and primary IPF fibroblasts, the authors show that TGF-β1 upregulates profibrotic genes (α-SMA and Col3A1) in both young and near-senescent cells, but that high-PDL (near-senescent/senescent) fibroblasts exhibit a delayed but sustained p38 MAPK response to TGF-β1. Pharmacological inhibition of p38 MAPK (SB202190) blunted profibrotic transcription and reduced H4K16 acetylation (H4K16ac) enrichment at α-SMA and Col3A1 promoters, indicating an epigenetic mechanism linking p38 signaling to fibrotic gene activation. “These findings suggest that a p38 MAPK–dependent epigenetic mechanism is involved in fibroblast activation, supporting the therapeutic potential of p38 MAPK inhibition for treating age-related fibrotic diseases such as IPF.” The authors place these molecular results in a clinical context: persistent fibroblast activation and senescence are features of IPF and other age-associated fibrotic disorders, and the data here support targeting p38 MAPK to interrupt an epigenetically reinforced profibrotic program. The study used multiple readouts (western blot, RT-qPCR, ChIP for H4K16ac) and included primary IPF cells to strengthen translational relevance, while also noting that further work is required to test safety and efficacy in vivo. The paper outlines clear next steps: determine the upstream triggers that sustain p38 signaling in near-senescent fibroblasts, map the chromatin-level events downstream of p38 that maintain H4K16ac at profibrotic promoters, and evaluate p38 inhibition in animal models of age-related pulmonary fibrosis. The authors also recommend exploring whether epigenetic modulators that reverse H4K16ac enrichment can synergize with kinase inhibition to restore repair capacity without impairing normal tissue healing. DOI - https://doi.org/10.18632/aging.206357 Corresponding author - Yan Y Sanders - sandery@odu.edu Abstract video - https://www.youtube.com/watch?v=yP0CwWMUhnY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206357 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, fibroblast activation, p38 MAPK, lung fibrosis, H4K16Ac To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Modern longevity culture can make "the perfect protocol" feel like the answer—especially when you're a busy mom who wants more energy now and a longer healthspan. Dan Pardi from Qualia (code: BRITTANY) breaks down what's changed in longevity science over the last 25 years—and why "healthspan" (feeling strong, clear, and capable for longer) matters more than simply living longer. We get into the real trade-offs of fasting, protein, and vitality, plus a clear explanation of what stem cells actually do, why they decline with age, and how "stem cell wellness" differs from clinic-based stem cell therapy. Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. WE TALK ABOUT: 00:00 - Why longevity finally feels "hackable" 03:55 - NAD explained and why it became an early longevity focus 10:10 - The fasting trade-offs that can crush vitality and metabolism 14:25 - Healthspan vs lifespan and what "living well longer" really means 24:45 - The non-negotiable foundations that beat any "longevity stack" 26:55 - What "stem cell wellness" is (and what it's not) 36:25 - Exosomes explained and why they're everywhere right now 44:25 - The truth about "plant stem cells" in skincare 51:30 - Senescent "zombie" cells, inflammation, and the case for senolytics RESOURCES: Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. Explore my luxury retreats designed to restore your nervous system, optimize health, and support true longevity. Download the non-toxic baby registry guide to reduce toxic exposure and make confident, evidence-informed choices for your family—free. Qualia's website (code: BRITTANY) and Instagram LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music
“Skin is our most visible biomarker of how we're aging on the inside,” explains Saranya Wyles, M.D., Ph.D. Wyles, a dermatologist, regenerative medicine scientist, and the director of the Regenerative Dermatology & Skin Longevity Lab at the Mayo Clinic, joins us today to unpack how the skin reflects systemic aging and the emerging therapies shaping the future of regenerative dermatology. - The skin's connection to longevity (~3:45) - Markers of skin aging (~5:20) - Senescent cells & systemic aging (~6:35) - 5 pillars of skinspan (~8:25) - How to eat for better skin (~10:20) - The role of exercise (~12:30) - The best topicals (~13:55) - Sunscreen & morning sunlight exposure (~17:05) - What are peptides (~20:20) - Lasers & longevity (~25:20) - Procedures to be mindful of (~32:40) - Underrated skin habits (~33:35) - The future of skin longevity (~35:15) - Cognitive function & skin health (~39:50) - Hair loss (~42:30) Referenced in the episode: - Follow Wyles on Instagram (@drwyles.derm) - Check out her research (https://pubmed.ncbi.nlm.nih.gov/?term=saranya+wyles) - The Baltimore Longitudinal Study of Aging (https://www.nia.nih.gov/research/labs/blsa/about) - Participate in the Skin Aging And Longevity Understanding Database (SALUD) (https://www.mayo.edu/research/clinical-trials/cls-20578108) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa What if the real driver of skin aging isn't wrinkles or sun damage — but "zombie" senescent cells hiding in your skin? In this episode of the Optimal Protein Podcast, Vanessa sits down with Dr. Alessandra Zonari, PhD — a stem cell biologist and longevity scientist — for a fascinating deep dive into the new peptide science behind skin aging, inflammation, and biological age. BOOST YOUR COLLAGEN & ELASTIN with RED LIGHT THERAPY! Save 25% on all Tone Lux Red Light therapy with the code HOLIDAY25! Learn more about the TONE LUX Crystal red light therapy mask and the brand new accessory the TONE LUX CONTOUR for the neck and décollete You'll discover: What senescent "zombie" skin cells actually are — and why they don't just age themselves, but affect the surrounding tissue How inflammation in the skin can quietly accelerate collagen breakdown and visible aging Why skin aging speeds up during fat loss, perimenopause, and menopause How scientists are now measuring the biological age of skin, not just how it looks The surprising role of peptides in signaling skin cells to behave more youthfully Why some common "anti-aging" approaches may miss the real drivers of aging What makes lip skin biologically different — and why it tends to age faster than the rest of the face Why nighttime repair, autophagy, and even red light therapy may matter more than you think This conversation goes far beyond skincare routines. It explores the mechanisms of aging at the cellular level, how lifestyle choices influence skin health, and why skin may be one of the most overlooked markers of longevity. If you're interested in skin health, peptides, collagen, inflammation, fat loss, or aging well, this episode will completely change how you think about your skin. Mentioned in this episode: OneSkin is powered by the breakthrough peptide OS-01, the first ingredient proven to reduce skin's biological age. I use the OS-01 Face and Eye formulas daily—they've transformed my skin's smoothness, firmness, and glow. Visit oneskin.co/VANESSA and use code VANESSA for 15% off your first purchase. Vanessa discusses how red light therapy supports mitochondrial health, muscle recovery, circulation, and skin health as part of an evidence-based approach to fat loss and metabolic optimization. Explore the Tone LUX red light therapy collection at
There were MANY GEMS in today's puzzle, and that's not even counting 3D, A host of, MANY, and 34A, Prized people, GEMS. We had 8D, Senescent, OLD; 48D, Real hoot, RIOT; and the colorful (?) 22D, Camel and fawn, TANS. Those were just the tip of the proverbial iceberg, though, because today's grid was chockfull of awesome clues. We dive into the deets in today's episode, so do have a listen, and be sure and tell all your friends about us as well: we appreciate the biz!Show note imagery: Robert H. Goddard, definitely the best-of-the-best when it comes to ROCKETSCIENCEA reminder that the holiday season will soon be upon us, and there's no better present than a gift of the NYTimes crossword! Operators (well, ok, bots) are standing by, so cruise on over to the NYTimes and buy your loved ones the gift that keeps on giving!We love feedback! Send us a text...Contact Info:We love listener mail! Drop us a line, crosswordpodcast@icloud.com.Also, we're on FaceBook, so feel free to drop by there and strike up a conversation!
Dr, Galati starts the program talking about holiday gift giving and high blood pressure. He also explains the science of senescent cells. Dr. Galati describes how zombie cells arise and how they relate to anti-aging and life span.
BUFFALO, NY — October 17, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, “Runx1 overexpression induces early onset of intervertebral disc degeneration.” In this study, led by first author Takanori Fukunaga from Emory University School of Medicine and corresponding author Hicham Drissi from Emory and the Atlanta VA Medical Center, researchers found that the Runx1 gene, when overactive in spinal disc cells, can accelerate age-related degeneration of the intervertebral discs. The findings offer new insight into the genetic factors that drive disc aging and suggest possible directions for treating chronic back pain. Intervertebral discs cushion the spine and support movement. Their deterioration is a major cause of lower back pain, especially with aging. At the center of each disc is the nucleus pulposus (NP), a gel-like core that contains proteins such as collagen and aggrecan, which help retain water and maintain structure. As people age, NP cells often lose their function, contributing to disc breakdown. Using a genetically modified mouse model, the researchers activated Runx1 specifically in NP cells. These mice developed signs of disc degeneration by five months of age, which is much earlier than normal. The overexpression of Runx1 led to the loss of healthy NP cells, an increase in abnormal cell types, and damage to disc structure. Levels of essential proteins like aggrecan and type II collagen decreased, while type X collagen increased, signaling unhealthy tissue changes. “To achieve NP-specific postnatal overexpression of Runx1, we crossed Krt19CreERT mice with Rosa26-Runx1 transgenic mice previously generated in our laboratory.” A key finding was that Runx1 overactivity did not kill cells directly. Instead, it caused premature cellular aging, known as senescence. Senescent cells lose the ability to repair tissue, creating an environment that accelerates degeneration. Markers of senescence were significantly elevated in the affected discs. The researchers also observed a dose-dependent response. The more Runx1 was activated, the more severe the degeneration was. This suggests that targeting Runx1 may be a promising strategy to prevent or slow disc aging. Overall, this study highlights the genetic and cellular processes that contribute to intervertebral disc degeneration, a leading cause of disability. By identifying Runx1 as a potential driver of early disc aging, the research opens new opportunities for intervention and treatment of degenerative spine conditions. DOI - https://doi.org/10.18632/aging.206316 Corresponding author - Hicham Drissi - hicham.drissi@emory.edu Abstract video - https://www.youtube.com/watch?v=BPwWbVBPIUM Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206316 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - cell senescence, aging, Runx1, nucleus pulposus, intervertebral disc degeneration To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
In this episode Dr's J and Santhosh continue their halloween hijinks moving on from the undead to the walking dead as they continue to discuss medicine of the spooky! Along the way, they cover the monster mash, historical Haitian zombies studies, tetrodotoxin, the reason zombies need brains, developing undead immunity and the Z nation, our own zombie senescent cells, Tutankhamun's curse and its medical veracity, the real dangers of opening tombs, cancer fighting curses and more! So sit back, relax and join us as we dig up information on grave diseases!Further Readinghttps://www.scientificamerican.com/blog/primate-diaries/a-natural-history-of-vampires/ https://www.jstor.org/stable/3814375https://pmc.ncbi.nlm.nih.gov/articles/PMC139048/https://www.livescience.com/health/fungus-that-may-have-caused-king-tuts-curse-shows-promise-in-treating-cancerhttps://www.nia.nih.gov/news/does-cellular-senescence-hold-secrets-healthier-aging#:~:text=Senescent%20cells%20are%20unique%20in,and%20related%20dementias%2C%20and%20osteoarthritis.Support Us spiritually, emotionally or financially here! or on ACAST+travelmedicinepodcast.comBlueSky/Mastodon/X: @doctorjcomedy @toshyfroTikotok: DrjtoksmedicineGmail: travelmedicinepodcast@gmail.comSpotify: https://open.spotify.com/show/28uQe3cYGrTLhP6X0zyEhTPatreon: https://www.patreon.com/travelmedicinepodcast Hosted on Acast. See acast.com/privacy for more information.
In this episode Dr's J and Santhosh open their 12th season with the much looked forward to Halloween special! Along the way, they cover Young Frankenstein, the disease risks of dead bodies, the morticians guide to the recently deceased, vampire tuberculosis and the mercy brown incident, how decomposition can make the dead appear alive, vampire medical weakness to water, possible medical origins of shapeshifting myths, rabies, porphyria and historical blood drinking, medical phlebotomy and vampire cures, the celtic curseFurther Readinghttps://www.scientificamerican.com/blog/primate-diaries/a-natural-history-of-vampires/ https://www.jstor.org/stable/3814375https://pmc.ncbi.nlm.nih.gov/articles/PMC139048/https://www.livescience.com/health/fungus-that-may-have-caused-king-tuts-curse-shows-promise-in-treating-cancerhttps://www.nia.nih.gov/news/does-cellular-senescence-hold-secrets-healthier-aging#:~:text=Senescent%20cells%20are%20unique%20in,and%20related%20dementias%2C%20and%20osteoarthritis. Hosted on Acast. See acast.com/privacy for more information.
BUFFALO, NY — September 23, 2025 — A new #research paper was #published in Volume 17, Issue 8 of Aging-US on August 7, 2025, titled “Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction.” This study, led by first authors Francesco Neri and Shuyuan Zheng, together with corresponding authors Denis Wirtz, Pei-Hsun Wu, and Birgit Schilling from the Buck Institute for Research on Aging, the USC Leonard Davis School of Gerontology, and Johns Hopkins University, reveals that not all aging cells behave the same. The researchers identified key differences between senescent cell subtypes that may influence how well they respond to senolytic drugs. These findings could help guide the development of more effective therapies for age-related diseases. Senescent cells are aged or damaged cells that stop dividing and accumulate in tissues over time. While they play a role in wound healing and protecting against cancer early in life, they can drive chronic inflammation and tissue decline with age. Researchers are exploring ways to selectively remove these cells using senolytic drugs. However, the large variety of senescent cell types has made it difficult to design treatments that work for all of them. This study aimed to better understand the functional differences among senescent cell subpopulations. Using high-resolution imaging, the team analyzed thousands of human endothelial and fibroblast cells growing in the lab. They observed that cells that exited the cell cycle (stopped dividing) in a later phase showed stronger signs of senescence and were more sensitive to senolytic treatment. These cells also produced more IL-6, a molecule associated with inflammation. The findings suggest that DNA content, which varies depending on the cell cycle phase, plays an important role in how aging cells function and how they respond to drugs. “We found that G2-arrested senescent cells feature higher senescence marker expression than G1-arrested senescent cells.” This is the first clear evidence that senescent cells do not all respond equally to treatment. The results suggest that future senolytic therapies could be more successful if they are designed to target specific subtypes of senescent cells, especially those with greater inflammatory potential. While this research was conducted in laboratory cell cultures, it provides a foundation for studying how these findings apply to living tissues. Future work will examine whether similar patterns occur in the body and how this knowledge could lead to more precise and effective treatments for age-related conditions. Understanding the diversity of aging cells is key to developing therapies that are both safer and more targeted. DOI - https://doi.org/10.18632/aging.206299 Corresponding authors - Denis Wirtz — wirtz@jhu.edu, Pei-Hsun Wu — pwu@jhu.edu, and Birgit Schilling — bschilling@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=x8bhKEFLzqA Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206299 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, imaging, heterogeneity, senolytics, cell cycle To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach.Some links are affiliate links so we will earn a commission when they are used to purchase products.In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. Dr. Robbins also shares insights into next-generation compounds his lab is developing and hints at positive clinical trial results coming soon.
Today, I'm joined by the trailblazing Liz Parrish, a true pioneer in the world of longevity science and regenerative medicine. Liz doesn't just talk about cutting-edge gene therapies—she's the first patient to actually undergo many of them herself. In our conversation, Liz shares how her journey from stem cell advocacy to biotech innovation was fueled by a deeply personal mission: her son's diagnosis with type 1 diabetes. What we discuss: How Liz Parrish got into genetics and stem cells ... 00:06:45 Transition from childhood disease to treating aging ... 00:09:35 Difference between stem cells, gene therapy, and exosomes ... 00:14:20 Challenges in gene therapy delivery and cell reprogramming ... 00:19:22 Liz Parrish as patient zero for gene therapies ... 00:22:01 Results and lessons from Parrish's self-experimentation ... 00:23:16 Senescent cells, telomeres, and aging interventions ... 00:29:22 Evolution and progress in gene therapy ... 00:34:14 Barriers and ethics of gene therapy for rare diseases and children ... 00:36:53 Public perception and future accessibility ... 00:44:55 Affordability, scaling, and redosing gene therapies ... 00:55:00 Practical longevity habits and hormones ... 01:03:54 Our Amazing Sponsors: OraltidePro™️by Profound Health - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), helps with enamel remineralization, reduces bacteria growth and etching and fills slots in damaged enamel. Check out OraltidePro™️at profound-health.com and use code NAT15 for 15% off your first order. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Fresh-Pressed Olive Oil Club: Get a full-size $39 bottle of one of the world's finest artisanal olive oils — fresh from the new harvest—for just $1. No commitment to buy anything, now or ever. Go to GetFreshLongevity.com for a free bottle and pay just $1. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Summary In this truncated replay from a session at the 2025 SF Derm Annual Conference, Dr. Daniel Butler discusses the relationship between allergic diseases, particularly chronic itch, and aging. He highlights the increasing prevalence of itch in older adults, the complexities of diagnosing and treating it, and the role of the immune system in this process. The conversation emphasizes the need for dermatologists to understand the unique challenges faced by geriatric patients and to improve the approach to treating chronic itch. Takeaways - Itching is a significant indicator of the aging process. - The population of older adults is rapidly increasing. - Chronic itch is often misdiagnosed or oversimplified. - Understanding the immune system's role is crucial in treating older patients. - Aging skin presents unique challenges for dermatologists. - The connection between itch and aging is well-documented. - Geriatric dermatology is relevant for all dermatologists. - Senescent cells contribute to chronic inflammation in aging. - Education on chronic itch needs to be improved in dermatology. - Historical perspectives on itch can inform current practices. Chapters 00:00 - Introduction to Allergic Diseases in Dermatology 02:57 - The Connection Between Itch and Aging 05:38 - Historical Perspectives on Itch in Older Adults 08:47 - Understanding the Aging Immune System and Inflammation
“Everything changed for the gay choral movement because they had twins: music and mission. They weren't just there for the music, and they weren't just there for the mission. I've been feeding my twins every day, and I feed them equally. Audiences that are interested in just music for music making are dying out. There are a lot more reasons to get them in: many concerts can reach into the community and be of service.”Tim Seelig is a conductor, speaker, author and educator. He is the Conductor Laureate of the San Francisco Gay Men's Chorus and Conductor Emeritus of the Turtle Creek Chorale in Dallas, Texas. He serves as founding conductor of the Portland Sage Singers.Dr. Seelig holds four degrees, including a Diploma from the Mozarteum in Salzburg, Austria and Doctor of Musical Arts from the University of North Texas. He has eight books and DVDs on choral technique published by Hal Leonard Music, several of which are best-sellers. His memoir, Tale of Two Tims, was published in 2020. He made his operatic debut in St. Gallen, Switzerland and solo debut at Carnegie Hall. He has been conducting at Carnegie Hall and Lincoln Center for 30 years, including an upcoming appearance at Lincoln Center in November 2025.He has conducted over 60 recordings which have been on Billboard Top Ten and iTunes Top Ten classical charts. His choruses have been the topic of three documentaries. The first PBS documentary was awarded the national Emmy for best documentary. The most recent had its world premiere at the Tribeca Film Festival, won the Audience Favorite and is streaming on Paramount +.He has commissioned major choral works for 35 years. Some of these include the first AIDS Requiem, When We No Longer Touch; Sing for the Cure for the Komen Breast Cancer Foundation featuring Dr. Maya Angelou; “Testimony,” by Stephen Schwartz and the 2022 “Songs of the Phoenix” by Andrew Lippa, Stephen Schwartz and Stephen Sondheim.Aside from guest-conducting, he is often seen trading in his podium for the speaking stage. He won the Moth Grand Slam and his recent TEDx Talk has passed 100K views.Fun facts: he conducted the Guinness Book of World Records Longest Choral Concert and carried the Olympic torch as a community Hero. He has not run since.He is the proud grandfather of the amazing Clara Skye, Eden Mae, Cora Rose, and Ivy Hope.To get in touch with Tim, you can find him on Facebook (@tim.seelig) or email him at tgseelig@gmail.com.Email choirfampodcast@gmail.com to contact our hosts.Podcast music from Podcast.coPhoto in episode artwork by Trace Hudson
Intervija tapusi sadarbībā ar Huawei Technologies Latvija.Mēs dzīvojam laikmetā, kad pirmo reizi vēsturē varam objektīvi mērīt un optimizēt savu veselību. Bet tikai tad, ja zinām, ko mērīt un kā iegūtos datus pārvērst konkrētās darbībās.Šajā sarunā ar zinātnieku un ārstu Uģi Klētnieku pievēršamies tēmai, kā mūsdienu tehnoloģijas un jaunākie atklājumi ilgdzīvošanas jomā var palīdzēt pagarināt mūsu veselīgo dzīves laiku. Uģim ir ārsta izglītība, viņš nodarbojas ar pētniecību, ir Longevity Alliance Baltic zinātniskās padomes priekšsēdētājs un Baltic Association of Precison Medicine valdes loceklis, kā arī strādā ar Latvijas olimpiešiem. Viņa zinātniskās intereses ietver dzīvildzes pagarināšanu un novecošanās mehānismus.Sarunā pieminētās informācijas saites atradīsi 231.sarunas lapā.SARUNAS PIETURPUNKTI:0:00 Ievads2:23 Uģa Klētnieka medicīniskā izglītība, profesionālais ceļš un mērķi ilgdzīvošanas jomā7:58 Aizraušanās ar kalnos kāpšanu, riski un laika ieguldījums 11:45 No alpīnisma uz ilgdzīvošanas medicīnu14:30 Slimo aprūpe nav tas pats, kas veselības aprūpe16:30 Darbs ar Latvijas Olimpisko vienību – sportistu ģenētiskie testi un uztura uzlabošana21:00 Par tehnoloģiju izmantošanu olimpiešu uzraudzībai, uzturam un pārtrenēšanās novēršanai23:53 Personīgā pārtrenēšanās pieredze Elbrusā26:49 Jaunākie ilgdzīvošanas zinātnes atklājumi.29:40 Senescentās jeb zombiju šūnas - novecojušo šūnu problēma un risinājumi32:11 Miljardieru investīcijas ilgdzīvošanā - vai bagātie dzīvos mūžīgi?40:28 Ilgdzīvošanas mīti - "zilo zonu" kritiskā analīze43:37 Kāpēc latvieši pēc 40 gadiem sporto tik maz47:25 Nepieciešamie ikdienas paradumi ilgdzīvošanai - četri galvenie pīlāri51:40 Viedpulksteņi un veselības mērījumi optimālai veselībai un sporta sniegumam57:25 VO2 max kā veselības indikators59:53 Viedpulksteņu praktiskā lietošana – pieredze ar Huawei Watch 51:06:20 Iekaisuma procesi fiziskās slodzes ietekmē un to kontrole1:15:03 Treniņu līdzsvara atrašana – risks, kas saistīts ar pārlieku mazu un lielu slodzi
Dr. Sherr is a member of the Undersea and Hyperbaric Medical Society and the Society of Hospitalist Medicine. He has a special interest in the use of HBOT for traumatic brain injury and stroke. New episodes of Welcome to Wellness released every Friday! Not listening on Spotify? Show notes at: https://www.ashleydeeley.com/w2w/scottsherr Episode brought to you by: Dry Farm Wines Episode brought to you by: Thyroid Fixxr (Code: WELCOMEWELLNESS) Episode brought to you by: VieLight (Code: DEELEY10) 10:15: When to use HBOT 13:32: How HBOT helps the brain 21:38 : Senescent or Zombie cells 22:00: Tips for jet lag (say no to carbs!) 25:05: My favorite Methylene Blue 25:40: Troscriptions (trochees) plus My favorite Methylene Blue 33:19: Hard chambers vs. soft chambers Where to find Dr Scott Sherr: Instagram Health Optimization Medicine Website LinkedIn Where to find Ashley Deeley: Website Instagram Facebook YouTube hello@ashleydeeley.com
Are you trying to lower inflammation? Maybe you've got to kill those senescent (aka Zombie) cells to accelerate healing. Learn all about how senolytics taken just once a month and other hacks can add life to your years by helping the body clear cells that are old, yet don't know how to die. Naturopathic physician, senolytic expert and SVP of Product Development at Qualialife Gregory Kelly explains the science behind senescent cells. Dr. Kelly was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. We cover: Senescent cells, zombie cells How to get rid of them Who needs to be concerned about senescent cell build up What it means What's better - fasting or supplements What women in peri and post menopause need to know about senescent cells Senescent cells and menopause Incredible results for women with joint pain and fatigue Get qualialife.com/hackmyage code HACKMYAGE 15% off Contact Gregory Kelly and Qualia: Website: https://qualialife.com/hackmyage Facebook: https://www.facebook.com/Qualialife Instagram: https://www.instagram.com/qualialife/ LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/ Give thanks to our sponsors Qualia senolytics and brain supplements. 15% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA here. Get Mitopure Urolithin A by Timeline. 10% discount with code ZORA at https://timeline.com/zora Visit https://getkion.com/zora for 20% off Kion Essential Amino Acids Try OneSkin skincare for with code ZORA at https://shareasale.com/r.cfm?b=2685556&u=4476154&m=102446&urllink=&afftrack= Join Biohacking Menopause before February 1, 2025 to win Kion Essential Amino Acids. 20% off with code ZORA at https://getkion.com/zora https://biohacking-menopause.mn.co Join the Hack My Age community on: Facebook Page : @Hack My Age Facebook Group: @Biohacking Menopause Instagram: @HackMyAge Website: HackMyAge.com Membership group: Biohacking Menopause Email: zora@hackmyage.com This podcast is edited by jonathanjk@gmail.com
In this episode, Dr. Mary Alice Mina discusses the key takeaways from her interview with Dr. Cory Goldberg, focusing on achieving timeless, beautiful skin through a holistic approach. She emphasizes the importance of skin health, lifestyle choices, nutrition, exercise, and the role of sun protection. Dr. Mina also highlights the significance of understanding senescent cells in aging and the need for ethical practices in aesthetics. Tune in for key insights from the latest podcast episode featuring Dr. Cory Goldberg. Key Takeaways: - True beauty and aesthetics come from the inside out. - Skin health is paramount for overall health. - Lifestyle choices make up 90% of skin health. - An ounce of prevention is worth a pound of cure. - Nutrition plays a crucial role in skin health. - Resistance training is essential as we age. - Senescent cells contribute to aging and need to be addressed. - Sun protection is vital for maintaining youthful skin. - Seek ethical care from trained professionals in aesthetics. - A holistic approach to aesthetics yields the best results. Follow Dr. Mina here:- https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin https://www.linkedin.com/in/drminaskin/ For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Website- https://www.atlantadermsurgery.com/ Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.
Send us a textIn this insightful episode, I am joined by Chris Mirabile, a visionary in the field of longevity and the founder of Novos, a company at the forefront of combating aging through science-backed strategies and natural innovations. Chris shares his personal journey of health challenges and triumphs, which led him to a lifelong commitment to understanding the science of aging and optimizing human potential. His mission to bridge the gap between cutting-edge biotech and accessible health solutions has made him a trailblazer in the field of longevity.Our conversation dives deep into the 12 hallmarks of aging, a revolutionary framework for understanding the biological mechanisms behind the aging process. We also explore actionable lifestyle changes and the synergistic role of nutrition, supplements, and mindfulness in enhancing healthspan and lifespan. From the potential of senescent cell management to the transformative power of personalized health strategies, Chris provides valuable insights for anyone seeking to live a longer, healthier, and more vibrant life. Tune in to uncover the secrets to slowing aging and unlocking your full potential.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today's Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode: Health transformation through adversity [00:01:22]Health transformation through adversity [00:05:06]Defining aging at the cellular level [00:09:41]Novos Longevity Diet Optimization [00:12:29]Nutrient inadequacies in modern diets [00:17:04]Testing for vitamin levels [00:20:29]Iron levels and health risks [00:24:51]12 hallmarks of aging [00:29:22]Cellular senescence and longevity [00:31:51]Fasting mimetics and longevity [00:35:54]Trace doses of lithium benefits [00:39:44]Telomere shortening and lifespan [00:45:10]Stem cell exhaustion and aging [00:48:17]Microbiome dysbiosis and health [00:51:31]Synergistic effects of formulas [00:56:48]Lifestyle strategies affecting aging [01:03:12]Nervous system's impact on supplements [01:06:07]Longevity accessibility for everyone [01:10:34]Slowing down aging [01:12:17] SlowMyAgeWebsiteNovos LabsWebsiteNovos Life AppFree mobile app available on iOS and Android, featuring a biological age test, personalized lifestyle guidance, and integrated LLM (AI-powered guidance).PeopleChris MirabileLinkedIn ProfileInstagram (@slowmyage)Andrés PreschelLinkedIn ProfileInstagram (@andrespreschel)Twitter (@andrespreschel)Dan BuettnerWikipediaBluSupport the show
Angela talks to Dr Alessandra Zonari the chief scientific officer and founding member of OneSkin. They explore the critical role of collagen in maintaining youthful skin, the impact of senescent cells—often referred to as "zombie cells"—on skin health, and how OneSkin's innovative OSO-1 peptide targets these cells to promote collagen production and improve skin function. Dr. Zonari also shares her journey from academia to developing groundbreaking skincare solutions, emphasising the importance of a holistic approach to skin health that includes lifestyle factors such as diet, sleep, and sun protection. KEY TAKEAWAYS Research indicates that the skin around the eyes is biologically 20 to 30 years older than the skin on other parts of the face, highlighting the need for targeted skincare in this area. Senescent cells, often referred to as "zombie cells," accumulate with age and secrete inflammation, leading to collagen breakdown and impaired skin function. Targeting these cells is crucial for maintaining youthful skin. Collagen is essential for skin firmness and elasticity. Its production declines with age, particularly due to hormonal changes in women during menopause, which can exacerbate skin aging. The patented OSO-1 peptide is designed to reduce the burden of senescent cells, promote collagen production, and improve overall skin health. Continuous use can lead to long-term improvements in skin appearance and function. BEST MOMENTS "Senescent cells, also known as zombie cells, are damaged cells that start accumulating on the skin and produce inflammation, leading to collagen breakdown." "I tried so many products over the years... but they rarely deliver real visible results." "When we are getting older, the skin tissue starts to accumulate damage on the cells, and the cells that accumulate damage secrete inflammation." "I first discovered OneSkin's products at a biohacking event, and I'll admit I was a bit skeptical at first, but I am so glad that I did." "The OS1 peptide is a novel molecule that was specifically designed to target the accumulation of those zombie cells in the skin." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community Learn more about the science behind OneSkin and save 15% with code ANGELA at oneskin.co/angela Get 25% Off Bon Charge Red Light Therapy Face Mask ABOUT THE GUEST CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.
Alessandra Zonari, PhD is the co-founder and Chief Scientific Officer at OneSkin, but she isn't your typical scientist. She's a visionary with a passion for longevity, skin regeneration, and the occasional karaoke jam. After earning a degree in stem cell biology, and a doctorate in skin regeneration and tissue engineering, Alessandra joined OneSkin in 2017 as a founding member and Chief Scientific Officer. Her contributions include 20+ papers, 3 patents, and the development of their proprietary OS-01 peptide. Try One Skin at 15% off with code ZORA at oneskin.co/ZORA Contact Alessandra Zonari and One Skin: website: https://www.oneskin.co Instagram: https://www.instagram.com/oneskin.co/linkedin: https://www.linkedin.com/company/oneskin/ Get Primeadine by Oxford Healthspan. 15% discount with code ZORA here. Get Mitopure by Timeline. 10% discount with code ZORA at timeline.com/zora Try Magnesium Breakthrough by Bioptimzers. 10% discount with code HACKMYAGE at bioptimizers.com/hackmyage Join Biohacking Menopause before December 1, 2024 to win one of 3 copies of The Psilocybin Handbook for Women by Jennifer Chesak. Join the Hack My Age community on: Facebook Page : @Hack My Age Facebook Group: @Biohacking Menopause Instagram: @HackMyAge Website: HackMyAge.com Biohacking Menopause membership group Email: zora@hackmyage.com This podcast is edited by jonathanjk@gmail.com We cover: - How hormones affect skin - Should we care about wrinkles and aging skin? - What are senescent skin cells - Can skin formulations kill senescent cells? - Can stem cells repair tissue after an operation? - Which peptides are best for menopausal skin concerns? - Which are the best prevention methods for aging skin? - What to look out for in a good skincare product - Which ingredients and products do more harm than good - Why the OS-01 peptide is even better than other peptides - My personal experience with the One Skin brand --- Support this podcast: https://podcasters.spotify.com/pod/show/hackmyage/support
Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout Link to show notes: https://bit.ly/4gdmxES Key Takeaways: 02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.
Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout Link to show notes: https://bit.ly/4gdmxES Key Takeaways: 02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.
Chuck Edwards - "Downtown Soulville" - 45 [0:00:00] Music behind DJ: The Upsetters - "Jaywalking" - 45 [0:04:04] Larry O'Dell - "Nab Jones" - 45 [0:04:43] Sonny Forrest - "Mama, Keep My Wife at Home" - 45 [0:06:41] Little Joe Hinton - "Let's Start a Romance" - 45 [0:09:08] Little Nicky Soul - "I Wanted to Tell You" - 45 [0:11:43] Music behind DJ: Don Pierce - "20th Century" - 45 [0:13:56] Oliver Joy - "Keep Love Growing" - 45 [0:16:10] Carol Anderson - "Taking My Mind Off Love" - 45 [0:18:37] Bobby Garrett - "My Little Girl" - 45 [0:20:42] Barbara Mercer - "Call On Me" - 45 [0:23:17] The Tempos - "I'll Never Forget" - 45 [0:25:44] Music behind DJ: Lynn August - "Black Olives" - 45 [0:28:21] Tony Troutman - "So Much, She's Gone Away" - 45 [0:30:59] Harmonica George - "Freelance" - 45 [0:32:52] Willie Mabon - "I Won't Be Back No More" - 45 [0:35:21] Hosea Leavy & His Combo - "Oo-Wee Baby" - 45 [0:37:44] Music behind DJ: Willey Terry - "The Upslide" - 45 [0:40:22] Johnny Moore - "That's What You Said" - 45 [0:42:43] Lynn Williams - "How Can You Call Love Fascination" - 45 [0:44:53] Pointer Sisters - "Send Him Back" - 45 [0:46:59] Black Velvet - "An Earthquakes Coming (If You Don't Straighten Up)" - 45 [0:49:41] Lou Pride - "Phoney People" - 45 [0:52:08] Richard Knight - "Show Stopper" - 45 [0:54:22] Music behind DJ: L. Gardner and Orch. - "Senescent" - 45 [0:57:01] https://freeform.wfmu.org/playlists/shows/143541
Chuck Edwards - "Downtown Soulville" - 45 [0:00:00] Music behind DJ: The Upsetters - "Jaywalking" - 45 [0:04:04] Larry O'Dell - "Nab Jones" - 45 [0:04:43] Sonny Forrest - "Mama, Keep My Wife at Home" - 45 [0:06:41] Little Joe Hinton - "Let's Start a Romance" - 45 [0:09:08] Little Nicky Soul - "I Wanted to Tell You" - 45 [0:11:43] Music behind DJ: Don Pierce - "20th Century" - 45 [0:13:56] Oliver Joy - "Keep Love Growing" - 45 [0:16:10] Carol Anderson - "Taking My Mind Off Love" - 45 [0:18:37] Bobby Garrett - "My Little Girl" - 45 [0:20:42] Barbara Mercer - "Call On Me" - 45 [0:23:17] The Tempos - "I'll Never Forget" - 45 [0:25:44] Music behind DJ: Lynn August - "Black Olives" - 45 [0:28:21] Tony Troutman - "So Much, She's Gone Away" - 45 [0:30:59] Harmonica George - "Freelance" - 45 [0:32:52] Willie Mabon - "I Won't Be Back No More" - 45 [0:35:21] Hosea Leavy & His Combo - "Oo-Wee Baby" - 45 [0:37:44] Music behind DJ: Willey Terry - "The Upslide" - 45 [0:40:22] Johnny Moore - "That's What You Said" - 45 [0:42:43] Lynn Williams - "How Can You Call Love Fascination" - 45 [0:44:53] Pointer Sisters - "Send Him Back" - 45 [0:46:59] Black Velvet - "An Earthquakes Coming (If You Don't Straighten Up)" - 45 [0:49:41] Lou Pride - "Phoney People" - 45 [0:52:08] Richard Knight - "Show Stopper" - 45 [0:54:22] Music behind DJ: L. Gardner and Orch. - "Senescent" - 45 [0:57:01] https://www.wfmu.org/playlists/shows/143541
Dr. Peter Lidsky posits that aging is not merely a process of accumulating damages, as commonly believed, but rather a programmed adaptation akin to a part of the immune system. His hypothesis suggests that aging evolved to eliminate older individuals who might be susceptible to severe chronic diseases. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8 About the showThe Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. Learning with lowell linksYoutube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips:https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Peter Lidsky linkshttps://twitter.com/LidskyPeterhttps://www.linkedin.com/in/peter-lidsky-71997540 Timestamps00:00 Start00:10 who is Peter Lidsky / research / longevity01:30 Academia differences04:20 Aging explained and the Squirrel test07:20 Pathogen control hypothesis15:50 Lifespans different organisms (fanq)17:55 Natural experiments to prove/disprove (fanq)24:30 Implications of Theory of aging25:00 Senescent cells31:32 Therapeutics / interventions from his research33:00 Implications of his theory37:50 Limits of aging40:10 What do people need to see to believe his theory44:30 Show him the drug that is better than rapamycin46:40 Data sharing / organization to push forward48:50 What is slowing aging research49:50 Pleiotropic genes / aging52:00 Research at Hong Kong52:40 Focus of future research53:55 Devices for research56:00 Bryan Johnson Blueprint59:20 People to follow01:00:00 place to stay up to date01:01:30 Thanks for all the fish longevity #aging #agingresearch
Welcome! and Thank you for listening. We age and our cells age. About every three months our red blood cells turn over for example. What happens to the old cells? How do we eliminate them? Our immune system plays a vital role in eliminating old cells or senescent cells. Unfortunately, our immune system also slows down so we start to accumulate these "zombie" senescent cells. This month Nature magazine discusses new drugs and repurposed drugs to eliminate these cells. However, these medications also have side effects and substantial costs. Since we all age, should everyone start these medications or do we wait until there is a problem like diabetes, Alzheimers, or vascular disease? Another alternative might be to decrease the amount of zombie cells in the first place or protect our immune system so it functions longer. You guest it. Nutrition and exercise play a key role as an alternative to decrease zombie cell accumulation. Thanks for listening. If you want help preventing zombie cell accumulation or to enhance your health span, check out our website at doctordulaney.com https://www.amazon.com/Plant-based-Wellness-Cookbook-Generations-Cooking/dp/1733967702/ref=sr_1_3?crid=1U4J4U0SZUXUF&dchild=1&keywords=plant+based+wellness+cookbook&qid=1621083696&sprefix=plant+based+well%2Caps%2C173&sr=8-3 https://mypurewater.com/?sld=jdulaneyhttps://www.nature.com/articles/d41586-024-01370-4
Today, I am thrilled to connect with Dr. Nick Bitz, a renowned naturopathic physician specializing in Ayurvedic medicine. Dr. Bitz is an influential figure in the natural products industry, specializing in nootropics, anti-aging, medicine, biohacking, herbology, nutrition, and dietary supplements. He is currently the Senior Vice President of Product Development at Neurohacker Collective. In our discussion, we cover cellular senescence, zombie cells, and distinctions with autophagy, highlighting some hallmarks of the aging process. We discuss the gut microbiome and the significance of akkermansia, also exploring the impact of senomorphics and senolytics, brain aging, lifestyle factors, the challenges of sarcopenia, and anabolic resistance. Join us for today's enlightening conversation with Dr. Nick Bitz as we journey into various aspects of holistic health and wellness. IN THIS EPISODE YOU WILL LEARN: How modern lifestyle factors exacerbate age-related cellular dysfunction Why it is critically important to consume enough fiber each day Senescent cells and their impact on aging, health, and disease What is the difference between senolytics and senomorphics? How senolytics get used in a clinical setting to target different body parts Diet, lifestyle, and supplements for brain health How adaptogens are used in Ayurvedic medicine The role of senescent cells in muscle aging Dr. Bitz discusses the popular senolytic product he created with Neurohacker Collective Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Nick Bitz Neurohacker Collective Collective Insights Podcast Use the code EverydayWellness to save 15% on any Qualia formulation
Dive into the fascinating world of cellular aging and longevity with our guest expert, Dr. Greg Kelly. Dr Kelly is a fellow naturopathic physician & the vice president of product development at Qualia from Neurohacker Collective. From unraveling the mysteries of senescent cells to exploring cutting-edge regenerative medicine, we explore the intricate processes underlying aging and how they impact our health. Discover the role of stress, metabolism, and the immune system in the formation and clearance of senescent cells, and learn about the innovative work of Qualia by Neurohacker Collective. Tune in for a deep dive into the science of aging and practical insights for optimizing your cellular health. If you ALSO want to Resist aging at the cellular level, try Qualia Senolytic. Go to neurohacker.com/DRTYNA for up to $100 off and use code DRTYNA at checkout for an additional 15% off. On This Episode We Cover: 2:22 - Defining senescent cells 4:50 - The resources senescent cells use 6:46 - The causes of senescent cells & the hayflick limit 10:08 - Researching and tracking senescent cells in the body 14:59 - Stress on a cellular level & senescent cell accumulation 18:23 - Apoptosis & how to “detox” senescent cell 19:33 - Balancing autophagy 20:52 - Senescent cell prevention 23:33 - Types of cell death 26:21 - Quiescent cells 31:16 - Joint health & muscle tissue 34:50 - Senescent cells & organ transplantation 36:01 - Age reversal studies 38:53 - The microbiome and senescent cells 40:22 - The hallmarks of aging 41:36 - Polyphenols & alkaloids in the gut 43:34 - Senolytic supplements 46:23 - Hit & run dosing 52:29 - Other ways of preventing senescent cells 54:08 - Qualia pilot studies 58:40 - Qualia protocols 1:01:121- What to look out for while taking Qualia Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources. *Guest information* Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. greg@neurohacker.com https://www.facebook.com/neurohackercollective https://www.instagram.com/neurohacker/ https://www.linkedin.com/in/gregory-kelly-98b96b138/ *Qualia Discount for New Frontiers Listeners* If you're in your late 20's or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/3zpsaw3s for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase. *Show Notes* Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly Neurohacker Collective: https://tinyurl.com/3zpsaw3s Shape Shift: https://tinyurl.com/3zpsaw3s Alternative Medicine Review: https://tinyurl.com/56ad9av9 Textbook of Natural Medicine: https://tinyurl.com/56ad9av9 Qualia Studies: https://neurohacker.com/studies Inulin-Type Probiotics - A Review (Part 1 and 2): https://altmedrev.com/?s=inulin James Schmachtenberger: https://tinyurl.com/yjhkj8k9 Daniel Schmachtenberger: https://tinyurl.com/yz2da5r4 Quercefit: https://tinyurl.com/4646pu8p Study: The Hallmarks of Aging: https://tinyurl.com/5cdnnbuy Study: Hallmarks of aging: An expanding universe: https://tinyurl.com/2y8dtx27 The Achilles' heel of senescent cells: from transcriptome to senolytic drugs: https://tinyurl.com/3k2sxkrb The Clinical Potential of Senolytic Drugs: https://tinyurl.com/5xdy2kk9 Epigenetic clock analyses of cellular senescence and ageing: https://tinyurl.com/4vxany6p The relationship between epigenetic age and the hallmarks of aging in human cells: https://tinyurl.com/34m626a2 Qualia Mind: https://tinyurl.com/23xv42fj Vittorio Sebastiano: https://tinyurl.com/4md5xvxh *DrKF Resources* FxMed Blog: The 12 biological hallmarks of aging viewed through a functional medicine and functional longevity lens: https://tinyurl.com/5n6c5b84 Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano: https://tinyurl.com/2z54h5h8 DrKF Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/ Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/ Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/ Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/ Younger You book: https://youngeryouprogram.com/book/ Dr. Fitzgerald is actively engaged in award-winning clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice. She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women and is the author of the bestselling book Younger You: How to Reduce Your Bio Age and Live Longer, Better.
This week I interview longevity queen, Dr Sandra Kaufmann the author of the Kaufmann Protocol and Aging Solutions. Dr Sandra is the head of department of Anesthesiology at and just happens to be obsessed with longevity science. What started out as her own search to slow and reverse ageing turned into a comprehensive system that allows people to personalize their own regime to their particular set of problems or needs and goals. This ingenious system has revolutionized my approach and makes it so simple to construct a very personalized approach. There are innumerable things a person can read concerning aging, but at the most basic level, organisms age because their component cells age. We are all made of cells or cell products and as they falter, so do we. Because cell aging is multifactorial, the organization of these concepts is important. The Protocol organizes these various theories of cellular aging into seven categories or tenets. The information in this podcast discusses these concepts in the language of science. The following seven tenets encompass all of the presently known modes of cellular aging. Based on this organizational scheme, Dr Kaufman then developed a strategy where aging is curtailed in every category. The 7 Tenets are as follows: DNA alterations (telomere attrition, epigenetics) Mitochondrial failure Pathways (Sirtuins, AMP Kinase, mTOR) Quality control (DNA & Protein repair mechanisms and Autophagy) Immune and inflammatory systems Individual cell needs (Senescent, Stem cells) Waste management (Glycation, lipofuscin) Dr Kaufman explains her rating system for various longevity molecules and how to utilize these in your protocols. We also discuss many of the supplements and adjuvants that Dr Kaufmann recommends for each of these tenets and we look at other cutting edge regenerative modalities like Exosomes. Stem cells are fantastic in terms of longevity, however there are limitations. Exogenous stem cells are currently not available in this country. Meanwhile, autologous stem cells are only as healthy as the person they which they come. Exosomes, on the other hand, constitute up to 80% of the benefits seen with stem cells and are available through Dr Kaufmann in the United States at least, in addition to being less expensive. I highly recommend Dr Kaufman's books, these are major reference book that will serve those looking to optimise their health, performance and longevity. Links Below Dr Sandra Kaufmanns website https://kaufmannprotocol.com/ Dr Sandra's Books: The Kaufmann Protocol Book Aging Solutions Book If you are interested in getting Exosomes done after listening to the episode join Dr Kaufmann's interview reach out to me at support@lisatamati.com Instagram: @kaufmanantiaging BIO Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital, a nationally recognized center of excellence. Most recently, she was recognized as "Best in Medicine" by the American Health Council. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38 Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. 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Today, I am blessed to have here with me Dr Nick Bitz. He is a Doctor of Naturopathic Medicine specialising in Ayurvedic medicine. He is presently the Senior Vice President of Product Development at Neurohacker Collective, a company that uses complex systems research to create revolutionary solutions for health and well-being. Dr Nick is interested in Ayurvedic medicine because of his health crisis. When he was a kid, he fell out of a tree, causing a chronic back issue. Not letting his health crisis pull him down, Dr Nick began his journey of self-care and healing. He dives into Buddhist meditation, yoga, and Ayurveda. Eventually, he landed on acupuncture, where he saw the light that he would live a life free of chronic pain. He uses all the tools he can to heal himself. Ultimately, Dr Nick moved to India and focused on Ayurvedic medicine. In this episode, Dr Nick Bitz talks about what cellular senescence is and why it is related to the reason why humans age. He also discusses keeping healthy cells and developing resilience. Aside from that, Dr Nick dives into why fasting is critical to reset our bodies. Tune in as we chat about cellular senescence, fasting, developing resilience, Qualia Resilience Supplement, and building immune health. Get Qualia products here: neurohacker.com/ketokamp Coupon Code: KETOKAMP (good for 15% off order) Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/
When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don't need Big Pharma to keep us feeling young―we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies' cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “Blue Zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity. Shermer and Greger discuss: • why we age and die • lifespan, vs. healthspan • longevity escape velocity • how to determine causality in aging science • nutrition fads • the anti-aging industry • Centenarians Diet • Mediterranean Diet • Okinawan Diet • Red, White, and Blue Zones • plant-based eating • exercise, sleep, stress • the Anti-Aging 8 • cholesterol and statins • vaccines • brain supplements • UV protection • alcohol • Alzheimer's • social ties, friendships, and marriage. A founding member and Fellow of the American College of Lifestyle Medicine, Michael Greger, MD, is a physician, New York Times bestselling author, and internationally recognized speaker on nutrition, food safety, and public health issues.
In this episode, we dive into the world of regenerative medicine. Dr. Gonzalez discusses the power of stem cells and NK cells, exploring how they work and their potential to bring about changes in the body. He shares stories of individuals who have experienced remarkable transformations through these treatments, including the host Dr. Axe. The conversation also delves into the latest research on using stem cells for conditions such as autism, cancer, orthopedic issues, and autoimmune diseases. We touch on the benefits of PRP and exosomes as well. Additionally, we address the challenges and pitfalls within the regenerative industry, highlighting what to avoid. Finally, we explore the different tiers and options available in the field of regenerative medicine, including bone marrow and fat treatments. Tune in for a deep dive into the fascinating world of regenerative medicine. 02:09 Overcoming a spinal infection. 03:55 Radical improvement with stem cells. 09:09 Regulating the immune response. 11:29 Stem cells and their benefits. 20:56 Improvements in quality of life. 21:44 Improvements in autistic kids. 27:46 Senescent cell removal. 29:12 NK cells and their impact. 32:54 Connection between NK cells and co-infections 36:08 NK cells and stem cells. 39:24 Cell communication and exosomes. 45:39 Unique cord lining stem cells. 46:07 Stem cell aging and replication. 50:30 Dr. Rafael's clinic and consultations. 54:26 Stem cell research and therapies. Discover the Nutrition, Lifestyle, and Fitness Plan that Works Best with Your Body with InsideTracker! Get 20% off at INSIDETRACKER.COM/AXE20 Get 15% OFF your first Leela Quantum Tech (LEELAQ.COM) order with code ANCIENT Get $200 OFF a Coldture cold immersion tub (Coldture.com) with code AXE. Guests Links: www.rehealth.com @rehealth.stemcells Follow @healthinstitute on Instagram! www.instagram.com/healthinstitute Join Our Newsletter! www.thehealthinstitute.com/wellness-weekly
If there is one thing that humanity has been striving for since its inception, is the pursuit of longevity. Today I'm with Chris Mirabile, Founder & CEO of NOVOS Labs who brings us one step closer to cracking the code of aging and longevity and offers fascinating insight into the intersection of health, performance, and longevity. We discuss how short-term health strategies may not always contribute positively to longevity, and the nine hallmarks of aging that NOVOS Labs aims to address. These include loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. Chris's interest in health began when he was 12 and evolved into a passion after he was cured of a brain tumor when he was 16. Chris has researched and integrated longevity practices and interventions into his life for more than ten years, has achieved a biological age 13.6 years younger than his chronological age, and according to epigenetic tests like DunedInPACE, is aging 31% slower biologically than chronologically. As we dive deeper into the realm of aging and anti-aging strategies, we bring ourselves one step closer to a future where longevity is not just a dream, but a reality. Chris Mirabile graduated from NYU Stern School of Business and later won their business plan competition with his startup company, Hotlist, a location-based social network that scaled to 220 million people's social plans. Chris has launched multiple successful technology ventures and has advised biotech startups and NYU Langone Hospital. Vist novoslabs.com and use code NAT5 to save. Thank you to our sponsors for making this episode possible: BiOptimizers: Use code bionat10 at magbreakthrough.com/bionat LMNT: Visit DrinkLMNT.com/NAT - no code needed Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Chris: Instagram: instagram.com/slowmyage/ Twitter: twitter.com/slowmyage Website: slowmyage.com What we discuss: (0:03:00) - The Short-Term Health vs. Longevity Dilemma (0:10:34) - Balancing Strategies for Longevity (0:19:29) - Aging and Anti-Aging Formulations (0:28:32) - Autophagy and Microbiome in Aging (0:39:26) - Understanding Senescent Cells-Safest Approach (0:53:55) - Comparing Different Aging Clocks Key takeaways: Aging and longevity are complex processes with numerous factors at play, such as loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. Senescent cells, while often perceived negatively due to their contribution to aging, can also play beneficial roles in certain contexts such as wound healing and limiting fibrosis. However, current senolytics can pose risks due to potential toxicity and lack of precision in targeting the right cells. While strategies such as severe caloric restriction or prolonged fasting can contribute to longevity, they may also have detrimental effects on short-term health and performance. It's crucial to strike a balance and consider the long-term implications of these health strategies. The ideal time to start implementing longevity strategies, like Novos, is around late 20s to early 30s.
A Passion for Animal Wellness. Welcome to this week's episode of the Team Never Quit Podcast, where we explore the fascinating world of veterinary medicine and animal wellness. In today's episode, we are honored to have a distinguished guest, Dr. Terry Fossum, a world-renowned and board-certified veterinary surgeon. Dr. Fossum is a leading figure in the field of veterinary surgery, having earned international acclaim for her expertise. She is the author of a best-selling textbook on small animal surgery, a testament to her deep knowledge and commitment to advancing veterinary practices. With over 18,000 surgeries under her belt, Dr. Fossum has dedicated her career to the well-being of animals, striving to ensure that pets lead healthy and happy lives. As a respected authority in the veterinary world, Dr. Fossum has been invited to deliver over 1,000 lectures to veterinarians worldwide. Her insights have shaped the knowledge and skills of professionals across the globe. Her contributions extend beyond the operating room. Dr. Fossum's commitment to education and sharing her expertise has left an indelible mark on the veterinary community. - Purchase Dr. Fossums Pet Care products at drfossums.com & use code TEAMNEVERQUIT for 30% off! Products include: CBD (Great for Anxiety & Mobility) Topical product for scratching (w/ Oleander) Product for cognitive dysfunction in dogs COMING SOON: Really amazing, oral anti-itch product & a cardiac support product! In this episode you will hear: • In my world, I do soft tissue surgery. I don't even do orthopedic anymore. (9:54) • When I was at A&M, with the help of then governor Perry, we built a large laboratory practice facility. (11:06) • [Oleander] could be one of the most amazing natural compounds we have ever identified. (12:30) • Senescent cells are the reason that we age. I think we can slow it down. (13:50) • We do want to live longer and healthier. (13:47) • As the number of divisions that a cell has continues, eventually they start making mistakes. (14:07) • Some cells become senescent, which means they no longer divide. They sit in our body and secrete really inflammatory substances. (14:53) • If you give a chemotherapeutic to a person, you drive some cells into senescence. And those cells are no longer going to respond to the chemotherapeutic. (16:06) • Q: How much do you think it costs to get a drug approved through the FDA? A: 2 Billion Dollars [$2,000,000,000) (17:30) • When I hear that saying: “Dogs are man's best friend”, what I think of is that dogs really are man's best friend. (36:16) • [Marcus] A dog's love – Dog and God – that love that they show – unconditional – I wish I could love like that. (37:02) • Oleander and a couple of synolytics and I think we have a great product that we will all take. (60:07) • You can tell what kind of people people are by the way they treat their animals. (61:34) • [Marcus: My dog, Mr. Rigby, a service canine] Boy, he was my best friend, I loved him and he never said one word to me. (63:32) • Marcus: When I was a young man going to the SEAL teams, people weren't SEALS would make up all these grand stories about what it took to get through the program: They give you a puppy, and you have to raise him, and then you gotta kill him. I had to go through [my service dog] Mr. Rigby. And I was the one who had to put him down. I've never felt any kind of pain like that. (64:54)
Everyone wants to slow down the signs of aging, but very few people are going about it the right way. The negative aspects of aging are one of the most ubiquitous challenges to quality of life. However, one thing is for sure: scientists believe that a big part of the reason we experience aging the way we do is because of stressed or worn-out cells called senescent cells. Senolytics is a term used to describe ingredients shown to help decrease these damaging senescent cells. My guest on this show - Gregory Kelly - has helped to develop several rare and powerful compounds that have scientifically shown senolytic activity, and which collectively cover a broader range of mechanisms than existing senolytic supplements on the market. His protocol, which we discuss on this show, involves a two-day rejuvenation regimen that he suggests using every month. Intermittent short-duration dosing is the most common way that senolytics are used in studies, and data suggests that it can take weeks for senescent cells to re-accumulate in the body, which is why Greg recommends this approach. Greg's compound is called "Senolytic" and made by my friends at Neurohacker Collective. For the full episode page and shownotes, visit: https://bengreenfieldlife.com/senolytic Episode sponsors: Organifi (Red): Recharge your mind and body with a delicious superfood berry blend of premium, organic superfoods that contain potent adaptogens, antioxidants, and a clinical dose of cordyceps. Increase energy and boost nitric oxide levels with zero caffeine and only 2 grams of sugar. Go to organifi.com/Ben for 20% off your order. Seed: If you're taking supplements, but not a probiotic, you might be overlooking your gut—which affects your whole-body health. If you want to add a probiotic + prebiotic to your daily routine, use code BEN15 at seed.com/ben to redeem 15% off your first month of Seed's Daily Synbiotic. Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go Joovv.com/ben and apply code BEN. Element Health CBD: Full-spectrum CBD and by far the most potent stuff on the market. If you're dealing with sleeping problems, anxiety, or stress, you got to try it. It's been a game changer for me. Go to elementhealthsupply.com/ben and use code BEN15 for 15% off your entire order. Boundless Parenting Book: Everything you need to know about family, parenting, and raising healthy, resilient, free-thinking and impactful children. Go to boundlessparentingbook.com and pre-order your copy now. BGL CAREERS: Check out our open positions at BenGreenfieldLife.com/Careers. Shine Sedona: Join my family and me in Sedona Arizona from March 10-12, 2023 at an amazing event hosted by SHINE. I'll be giving a keynote talk on breathwork and biohacking, and hosting a VIP Greenfield-style home-cooked dinner prepared by my family. For tickets to the Shine Event where I'll be a keynote speaker visit bengreenfieldlife.com/shinesedona. To book your spot for our VIP dinner visit bengreenfieldspeaking.com/sedona-dinner.
This episode is brought to you by Rupa Health and Athletic Greens. To understand and combat rapid aging, we need to understand what causes aging, chronic diseases, and decline. We call these things the hallmarks of aging—the underlying common pathways or mechanisms of aging. Each hallmark is influenced by the others and affected by various imbalances—too much or too little of certain inputs that can negatively impact the expression and progression of the hallmark. Understanding those interactions and weblike connections is the key to solving the puzzle of aging. In today's episode of my series I'm calling Health Bites, I dive into the 10 distinct hallmarks of aging and how to address them. What I've discovered has blown my mind and changed the way I approach my own health and the health of my patients. I've compiled it all into a new book called Young Forever, which comes out on February 21, 2023. Learn more and preorder the book at youngforeverbook.com.This episode is brought to you by Rupa Health and Athletic Greens.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Here are more details from our interview (audio version / Apple Subscriber version):Disrupted hormonal and nutrient signaling (8:08 / 4:40) DNA damage and mutations (17:38 / 14:12) Telomere shortening (19:19 / 15:52) Damaged proteins (20:32 / 17:04) Epigenetic damage (22:56 / 19:29) Senescent cells (otherwise known as zombie cells) (25:11 / 21:43) Depleted energy and mitochondrial decline (26:44 / 23:17) The link between gut health and longevity (28:33 / 25:07) Stem cell exhaustion (30:38 / 27:14) Inflammaging and dysfunction in immune functioning (32:00 / 28:32) Hosted on Acast. See acast.com/privacy for more information.
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