Podcasts about igg4

Radiation for skin cancer - with Dr. Jacob Scott! -Lipedema - not just for social media (?) - Inebilizumab for IgG4 disease -HTN and PWS -Learn more about radiation therapy and other non-surgical options for skin cancer treatment at The Dermatology Association of Radiation Therapy: https://dermassociationrt.org/Join Luke's CME experience on Jak inhibitors! ⁠rushu.gathered.com/invite/ELe31Enb69⁠Learn more about the U of U Dermatology ECHO model!https://physicians.utah.edu/echo/dermatology-primarycare#:~:text=ECHO%20Model,being%20presented%20in%20the%20session.Want to donate to the cause? Do so here!Donate to the podcast: ⁠uofuhealth.org/dermasphere⁠Check out our video content on YouTube:⁠www.youtube.com/@dermaspherepodcast⁠and VuMedi!: ⁠www.vumedi.com/channel/dermasphere/⁠The University of Utah's DermatologyECHO: ⁠⁠physicians.utah.edu/echo/dermatology-primarycare⁠ -⁠ Connect with us!- Web: ⁠⁠dermaspherepodcast.com/⁠⁠ - Twitter: @⁠DermaspherePC⁠- Instagram: dermaspherepodcast- Facebook: ⁠www.facebook.com/DermaspherePodcast/⁠- Check out Luke and Michelle's other podcast,SkinCast! ⁠⁠healthcare.utah.edu/dermatology/skincast/⁠⁠ Luke and Michelle report no significant conflicts of interest… BUT check out ourfriends at:- ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge)- ⁠⁠www.levelex.com/games/top-derm⁠⁠ (A free dermatology game to learnmore dermatology!

A neuroinflammatory disorder with the potential to affect virtually any organ in the body, IgG4-related disease is a challenge on many fronts. The latest Editors' Choice paper in the June 2025 issue takes on this systemic disease, presenting a treatment algorithm for its management. This episode, PN's podcast editor Dr. Amy Ross Russell speaks with author Dr. Claire Rice. Hear an overview on the disease background, the signs in presentation, what to look for in the histology, and steroid treatment strategy.    Read the paper: IgG4-related disease in the nervous system    Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production by Amy Ross Russell and Brian O'Toole. Editing by Brian O'Toole. Thank you for listening. 

Many topics today! First: FDA tentatively approves Moderna's new mRNA shot for Covid. What? And also why? Bret has six main points, which include discussion of mucosal immunity, IgG4, auto-immunity, long-term consequences, statistical tricks, and homeopathy. Then: how do we know what is true, and how can we avoid jumping to conclusions when triggered by language or circumstances that seem familiar and frustrating?...As explored through the story of Algerian boxer Imane Khelif, who has a Disorder of Sexual Development, won Olympic gold for beating women, but is definitely male. Finally: brief discussions of Glenn Greenwald, and Richard Dawkins. No, Dawkins, religion is not a mental infection.*****Our sponsors:CrowdHealth: Pay for healthcare with crowdfunding instead of insurance. It's way better. Use code DarkHorse at http://JoinCrowdHealth.com to get 1st 3 months for $99/month.ARMRA Colostrum is an ancient bioactive whole food that can strengthen your immune system. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.Helix: Excellent, sleep-enhancing, American-made mattresses. Go to www.HelixSleep.com/DarkHorse for 20% Off sitewide.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:Moderna press release: https://investors.modernatx.com/news/news-details/2025/Moderna-Receives-U-S--FDA-Approval-for-COVID-19-Vaccine-mNEXSPIKE/default.aspxKennedy on FDA and Moderna shot: https://x.com/seckennedy/status/1930012848056365294Mary Talley Bowden MD on the shots: https://x.com/mdbreathe/status/1927899248575545501Heather on Imane Khelif: https://x.com/HeatherEHeying/status/1929920193771516423Greenwald on the situation: https://x.com/ggreenwald/status/1928440222771015912Dawkins on religion: https://x.com/richarddawkins/status/1930184916190257320Support the show

This episode's theme is new diseases, whether they are newly described, or old diseases back in a new form. We start off with IgG4-related disease, a chronic multisystem disorder that is still being understood. Then there is a genetics paper on repeat expansion disorders, a group of conditions often thought as disparate but with quite a few commonalities. Next along is a fascinating case following gastric sleeve bariatric surgery, highlighting the dangers of travelling for unsupervised surgeries, and raising the question, “Are you getting enough soil in your diet?” There's also a discussion of what else Hoover's sign might represent, and the evolution of immunoglobulin use. Closing the episode is a paper offering a masterclass on the assessment of best interests in  prolonged disorder of consciousness.   Read the issue: https://pn.bmj.com/content/25/3/199   Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening. 

AiArthritis diseases can be difficult enough to manage—but what happens when the symptoms don't fit neatly into a diagnosis? In this episode, AiArthritis Health Education Manager Leila shares her perspective on the “mystery patient” experience, those living with serious, ongoing symptoms but still searching for answers. Leila revisits key conversations from past episodes and introduces new resources, including our updated Mystery Patient Guide and the AUTO + Inflammatory Arthritis = X or YZ Project, which explores lesser-known or overlapping conditions like IgG4-related disease (IgG4-RD). She also shares the powerful story of a real mystery patient navigating the challenges of being undiagnosed for years. If you or someone you love is living in diagnostic limbo, this episode offers validation, education, and practical tools to help guide your journey and highlights why improving awareness and research for this often-overlooked community is so essential. Donate to Support the Show: www.aiarthritis.org/donate Episode Highlights: Learn why some patients remain undiagnosed for years and what defines a “mystery patient.” Hear a real patient story that illustrates the challenges of navigating misdiagnosis. Understand how overlapping conditions like IgG4-RD complicate the diagnostic process. Discover key takeaways from the IgG4-RD Educational Summit, including treatment updates. Explore tools and resources available to support those still searching for answers.   Links & Resources Mystery Patient Guide: www.aiarthritis.org/undiagnosed Volunteer with AiArthritis : https://bit.ly/AiArthritisVolunteerApp IgG4-RD Resource :https://igg4ward.org/education-and-resources Start Your Team for World AiArthritis Day: givebutter.com/aiarthritisday25  World AiArthritis Day Information: www.aiarthritis.org/aiarthritisday   Follow AiArthritis on all social media platforms @IFAiArthritis Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE   Connect with our Cohost: Leila P.L. Valete is the Health Education Manager at the International Foundation for AiArthritis. She is a person living with Lupus & Sjögren's. She is passionate about inclusion and diversity in health education and meeting individuals where they are at in order to learn in a way that resonates with them. Leila is on social media as @Lupus.Lifestyle.Lei sharing bits and pieces about her life with lupus and connecting with others.   Connect with Leila: Tiktok: @Lupus.lifestyle.lei

Marlies Dekkers in gesprek met Jan Bonte over vaccinatieschade en meer. "Vaccins zijn een uitstekende medische techniek, maar je moet het niet in handen geven van de verkeerde mensen."--Steun DNW en word patroon op http://www.petjeaf.com/denieuwewereld.Liever direct overmaken? Maak dan uw gift over naar NL61 RABO 0357 5828 61 t.n.v. Stichting De Nieuwe Wereld. Crypto's doneren kan via https://commerce.coinbase.com/pay/79870e0f-f817-463e-bde7-a5a8cb08c09f-- Bronnen en links bij deze uitzending: - Het vorige gesprek tussen Marlies en Jan Bonte, over de oorsprong van corona: https://www.youtube.com/watch?v=OV3XC7GE6Uc- Marlies in gesprek met Arno Wellens: https://www.youtube.com/watch?v=GtKcx-ldQco- Marlies in gesprek met Hester Bais: https://www.youtube.com/watch?v=948rgaGD05I- 'De Hommel vertelt - De Wuhan Trilogie', theatercollege van Jan Bonte: https://vimeo.com/ondemand/dehommelvertelt- Spurious correlations: https://www.tylervigen.com/spurious-correlations- Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections: https://www.journalofinfection.com/article/S0163-4453(25)00067-2/fulltext- Expression of SARS-CoV-2 spike protein in cerebral Arteries: Implications for hemorrhagic stroke Post-mRNA vaccination: https://pubmed.ncbi.nlm.nih.gov/40184822/--00:00 Introductie00:50 Oorsprong van het coronavirus8:41 Van corona-angst naar Poetinangst13:48 "Mijn kinderen hebben hier geen toekomst meer"16:28 "Grootste medische schandaal van de eeuw"32:01 DNA in vaccins?39:09 Meer ontvankelijk voor virus door vaccin?51:25 Enkele casussen1:06:18 Kan er nu nog wat aan gedaan worden?1:15:00 Afronding--De Nieuwe Wereld TV is een platform dat mensen uit verschillende disciplines bij elkaar brengt om na te denken over grote veranderingen die op komst zijn door een combinatie van snelle technologische ontwikkelingen en globalisering. Het is een initiatief van filosoof Ad Verbrugge in samenwerking met anchors Jelle van Baardewijk en Marlies Dekkers. De Nieuwe Wereld TV wordt gemaakt in samenwerking met de Filosofische School Nederland. Onze website: https://denieuwewereld.tv/ DNW heeft ook een Substack. Meld je hier aan: https://denieuwewereld.substack.com/

In this episode, we dive into the complexities of IgG4-Related Disease (IgG4-RD), a mysterious and multi-organ condition that continues to challenge both patients and physicians. Back in January 2024, Dr. John Stone introduced us to the emerging landscape of treatments for IgG4-RD, and today, Dr. Matthew Baker joins us to provide an exciting update. With new therapies on the horizon, we explore the role of B and T cell pathogenesis, the limitations of traditional steroid treatments, and the off-label use of rituximab. We also take a closer look at the promising results from the “Mitigate Trial,” which offers hope for future strategies in managing this enigmatic disease. Join us as we discuss the evolving treatment landscape and what lies ahead for those affected by IgG4-RD. 

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. The FDA is facing a potential "catastrophic collapse" due to massive layoffs that are endangering its user fee program, which provides nearly half of its yearly funding. More than half of the senior leadership at the agency has left, leading to a lack of communication, transparency, and human decency. The agency is at risk of losing its funding and ability to support its operations and employee salaries. In other news, Amgen has won an expansion for Uplizna as the first drug for IgG4-related disease, Lilly has made a pact with Sangamo worth a potential $1.4 billion, and Trilink offers custom guide RNAs for CRISPR workflows. The cell and gene therapy sector has seen a 30% investment surge despite market challenges.

America Out Loud PULSE with Malcolm Out Loud – My question is about gain of function research. Why is it still being done in America, and why hasn't anyone stopped this research from continuing? Is the damage caused by the covid vaccines irreversible? Has every vaccinated person destroyed their immune system because of the vaccine shifting the human body from producing just IgG1 and IgG3 to 20% IgG4 and is there anything that can be done to reverse it?

America Out Loud PULSE with Malcolm Out Loud – My question is about gain of function research. Why is it still being done in America, and why hasn't anyone stopped this research from continuing? Is the damage caused by the covid vaccines irreversible? Has every vaccinated person destroyed their immune system because of the vaccine shifting the human body from producing just IgG1 and IgG3 to 20% IgG4 and is there anything that can be done to reverse it?

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.

In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center's long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Influenza weekly surveillance report: cliff notes (CDC FluView) US respiratory virus activity (CDC Respiratory Illnesses) Influenza vaccines protect against secondary infections in households (JAMA Network) Benefit of early oseltamivir therapy for influenza A (CID) RSV-Network (CDC Respiratory Syncytial virus Infection) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Maternal infection of SARS-CoV-2 during 1st and 2nd trimesters newborn telomere shortening (Journal of Translational Medicine) What is a B1 cell? (Wikipedia) Pre-COVID and post-COVID vaccination on long COVID (Journal of Infection) Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies after  BNT162b2 Vaccination in Children (The Pediatric Infectious Disease Journal) Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine) Phase III trial results! Comparative efficacy and safety of COVID-19 vaccines (BMC Infectious Diseases) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID(Scientific Reports) Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine (BMC Infectious Diseases) Measurement of circulating viral antigens post-SARS-CoV-2 infection (CID) Letters read on TWiV 1172 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Send us a textPodcast episodes are fully available to paid subscribers on the M&M Substack and full video versions are free on YouTube. This episode will not be posted on YouTube due to the controversial nature of the content.About the guest: Jessica Rose, PhD is a computational biologist who has been studying and analyzing data from the Vaccine Adverse Event Responding System (VAERS) related to COVID. Episode summary: Nick and Dr. Rose discuss: Vaccine Adverse Event Responding System (VAERS); analysis of VAERS data for COVID; mRNA technology; spike protein persistence & lipid nanoparticles; common adverse events reported for the Pfizer & Moderna shots; myocarditis & menstrual irregularities; IgG4 antibodies, molecular mimicry & autoimmunity; and more.Related episodes:M&M #196: Vaccine Contamination & Fiat Science | Kevin McKernanM&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization of Science | Jay BhattacharyaSpecial offer: Use MINDMATTERSPECIAL2 for a free 1-year premium subscription to Consensus, an AI-powered research tool that helps you find the best science, faster. ($150 value, limited-time offer).*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. KetoCitra—Ketone body BHB with potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Consensus: AI-powered academic research tool. Find & understand the best science, faster. Free 1-year premium sub with code MINDMATTERSPECIAL (exp 12.10.24) Learn all the ways you can support my efforts...

Send us a textAbout the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project.Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vaccines; vaccine adverse events & IgG4 immune modulation; concerns with COVID PCR testing; origins of the SARS-CoV-2 virus; Fiat Science from the AIDS epidemic to today; how Big Pharma works with government regulators; decentralized medicine; and more.Related episodes:M&M #149: DNA & RNA Biology, mRNA Vaccines, Vax Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernanM&M #97: How Did the SARS-CoV-2 Virus Originate? | Alex WashburneSpecial offer: Use code MINDMATTERSPECIAL for a limited time to get a free 1-year premium subscription to Consensus, a new AI-powered research tool to help you find the best science, faster.*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. SiPhox Health—Affordable, at-home bloodwork. Comprehensive set of key health markers. Use code TRIKOMES for a 10% discount. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Consensus: AI-powered academic research tool. Find & understand the best science, faster. Free 1-year premium sub with code MINDMATTERSPECIAL (expires 12.10.24) Learn all the ways you can support my efforts...

America Out Loud PULSE with Dr. Peter McCullough and Malcolm – I find myself without a candidate -- with the looming possibility that our elections could be theater... I do get tight-chested and get irregular beating, but my ECGs and EKGs are fine. Should I worry?... How long does the spike protein from the vax last in the body?... The vaccine exhausts the T-cells and makes the body IGg4 tolerant, but is this true for everyone?

America Out Loud PULSE with Dr. Peter McCullough and Malcolm – I find myself without a candidate -- with the looming possibility that our elections could be theater... I do get tight-chested and get irregular beating, but my ECGs and EKGs are fine. Should I worry?... How long does the spike protein from the vax last in the body?... The vaccine exhausts the T-cells and makes the body IGg4 tolerant, but is this true for everyone?

Show Notes https://www.rushtoreason.com/show-notes/10-31-2024/

In this episode, Jonathan is joined by John H. Stone, Professor of Medicine at Harvard Medical School and The Edward A. Fox Chair in Medicine at Massachusetts General Hospital.  Stone discusses his groundbreaking work in systemic vasculitis, including granulomatosis with polyangiitis and ANCA-associated vasculitis. He also shares insights into the emerging field of IgG4-related disease and the exciting possibility of the first approved therapy for this condition. Alongside, he delves into his efforts to minimise glucocorticoid toxicity and his work through the IgG4ward! Foundation.   Timestamps: (00:30) – Introduction (04:00) – Stone's journey into rheumatology (07:28) – WEGET trial (10:30) – Developments in IgG4-related disease and the path to therapy approval (15:52) – Key advancements in the treatment of granulomatosis with polyangiitis (18:04) – Glucocorticoid toxicity and the Glucocorticoid Toxicity Index (GTI) (20:34) – The IgG4ward! Foundation (23:48) – Two Pearls and a Myth (26:45) – Stone's three wishes for rheumatology

This week Dr Thomas Bond covers IgG4 related disease. A tricky, rare condition, which can often mimic other problems, IgG4 RD is difficult to diagnose if the differential doesn't cross your mind. Get the highlights in the episode of MEMCast!

Dr. Stacey Clardy discusses how to test for IgG4-related disease and how to interpret MIR imaging findings. Show reference: https://ard.bmj.com/content/74/1/14a 

Dr. Stacey Clardy discusses the importance of iron and ferritin in neurology in this lab minute. Show reference: https://ard.bmj.com/content/74/1/14a 

Research is piling up to reveal that the mRNA vaccines increasingly weaken the immune system with each booster. Jefferey dives deeper into what “HighWire” guests Bret Weinstein, PhD and William Makis, MD both detail – multiple vaccinations causing a class switch in antibody production to an overproduction of IgG4, the antibody responsible for dampening immune response, and underproduction of IgG1 and IgG3, the antibodies responsible for cancer surveillance.

"Wie genau hängt das Leaky Gut Syndrom mit SIBO zusammen und kann man beides gleichzeitig behandeln?" "Welche Ernährungsform ist speziell für Menschen mit Leaky Gut zu empfehlen?" "Sollte ich zur besseren Heilung bei einem durchlässigen Darm auf bestimmte Lebensmittel verzichten?" "Was haltet ihr von einem IgG4 bzw. IgG5 Test?" "Habe ich durch meine Hashimoto-Erkrankung ein höheres Risiko an Leaky Gut zu erkranken?" "Wie lange hält der positive Effekt einer Darmsanierung an?" - vielen Dank für Eure Fragen zu unserer aktuellen Episode "Leaky Gut Syndrom: "Durchlässiger Darm" Ursache für starke Immunreaktionen und Entzündungen". Matthias Baum aus dem HEALTH NERDS Wissenschaftsteam liefert hier in der Sprechstunde Antworten. -- Zur Hauptfolge: Das "Leaky Gut Syndrom" beschreibt in der Wissenschaft die Effekte eines "durchlässigen Darms". Die Darmmembran wird durchlässig, schädliche Stoffe gelangen ungehindert in den Blutkreislauf, die Schutzfunktion der Darmschleimhaut gegen Krankheitserreger und Toxine ist empfindlich gestört. Gelangen größere Moleküle wie unverdaute Nahrungsbestandteile oder Mikroben durch die Darmwand in den Blutkreislauf, kann das starke Immunreaktionen und Entzündungen auslösen. Schätzungen gehen von bis zu 6 Millionen Betroffenen allein in Deutschland aus. Doch das "Leaky Gut Syndrom" wird nicht von allen Medizinern als eigenständige Erkrankung anerkannt, da die wissenschaftlichen Beweise noch begrenzt sind. Einige Forscher betrachten es eher als Begleiterscheinung oder Symptom anderer Erkrankungen. "Unausgewogene Ernährung, hoher Zucker- und Fettkonsum, chronischer Stress, Infektionen, die Einnahme von Antibiotika oder nicht steroidalen Antirheumatika und Erkrankungen wie Zöliakie oder Morbus Crohn gehören zu den möglichen Ursachen von Leaky Gut" - Matthias Baum aus dem HEALTH NERDS Wissenschaftsteam beschäftigt sich intensiv mit den Gründen für einen durchlässigen Darm. Er liefert in dieser Episode einen spannenden Einblick und liefert konkrete Tipps zu Diagnose, Therapie und Prävention: "Gut erforscht ist der Einsatz der Aminosäure L-Glutamin, um die Darmwand zu reparieren und Mikrorisse zu schließen." HEALTH NERDS. Mensch, einfach erklärt. -- Sichere Dir Dein RE'SET-Paket zur wissenschaftlich fundierten Darmsanierung - exklusiv für unsere HEALTH NERDS Community 15% günstiger mit dem Code: RESET15 im Warenkorb eingeben auf https://artgerecht.com/reset-darmsanierung-ernaehrungskonzept-paket-single -- Ein ALL EARS ON YOU Original Podcast.

Many autoimmune neuromuscular disorders are reversible with prompt diagnosis and early treatment. Understanding the potential utility and limitations of antibody testing in each clinical setting is critical for practicing neurologists. In this episode, Teshamae Monteith, MD, FAAN speaks with Divyanshu Dubey, MD, FAAN, author of the article “Autoimmune Neuromuscular Disorders Associated With Neural Antibodies,” in the Continuum® August 2024 Autoimmune Neurology issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. Dubey is an associate professor in the departments of neurology and laboratory medicine and pathology at the Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Autoimmune Neuromuscular Disorders Associated With Neural Antibodies Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Guest: @Div_Dubey Transcript Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME.   Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. Today, I'm interviewing Dr Divyanshu Dubey about his article on autoimmune neuromuscular disorders associated with neural autoantibodies, which is part of the August 2024 Continuum issue on autoimmune neurology. Welcome to the podcast. How are you?   Dr Dubey: Hi, Dr Monteith. Thank you for inviting me to be a part of this podcast. I'm doing well.   Dr Monteith: Well, why don't you introduce yourself to the audience? And, call me Tesha.   Dr Dubey: I'm Divyanshu Dubey (please, call me Div). I'm one of the autoimmune neurology consultants here at Mayo Clinic Rochester. I'm an Associate Professor of neurology, as well as lab medicine and pathology. My responsibilities here are split - partly seeing patients (primarily patients with autoimmune disorders, including neuromuscular disorders), and then 50% of my time (or, actually, more than 50%), I spend in the lab, either doing research on these autoimmune disorders or reporting antibodies in a clinical setting for various antibody panels which Mayo's neuroimmunology lab offers.   Dr Monteith: That's a nice overlap of subspecialty area. How did you get into this work?   Dr Dubey: I think a lot of it was, sort of, by chance. Meeting the right people at the right time was the main, sort of, motivation for me. Initially, I trained in India for my medical school and didn't really got much exposed to autoimmune neurology in India. I think our primary concern in my training was sort of treating TB meningitis and cerebral malaria - that was my exposure to neurology, including stroke and some epilepsy cases. As a part of application for USMLEs and coming here to residency, I did some externships, and one of the externships was at Memorial Sloan Kettering Cancer Center, and that's when I worked a few weeks with Dr Posner and got introduced to the idea of paraneoplastic neurological syndrome working with him. And that sort of started - I wouldn't call it vicious cycle - but my interest in the area of autoimmune neurology and paraneoplastic neurological disorders, which subsequently was refined further through residency and fellowships.   Dr Monteith: That's interesting. I actually rotated through - I did a externship also at Sloan Kettering, and I had a clinic with Dr Posner. And I thought, at the time, he was such a rock star, and, like, I took a picture with him, and I think he thought it was insane. And I didn't go into autoimmune neurology. So, you know, interesting pathways, right?   Dr Dubey: Yes. And I think he's inspired many, many people, and sort of trained a lot of them as well.   Dr Monteith: So, why don't you tell us what you set out to do when writing this article?   Dr Dubey: So, I think, given my background and training in various subspecialties in neurology, I was, sort of, formally did fellowships in autoimmune neurology, as well as neuromuscular medicine. One of the areas in these areas that I focus on is in my clinical practice, as well as in my sort of lab work, is autoimmune muscular disorders - and that to, specifically, autoantibodies and their clinical utility for autoimmune muscular disorders. So, that's what I wanted to focus on in an article. When I was invited to write an article on autoimmune muscular conditions in general, I thought it was very difficult to pack it all in one chapter or one article, so I narrowed my focus (or tilted my focus) towards antibody-positive disorders and trying to understand how we as neurologists can firstly sort of identify these conditions (which may end up being antibody-positive) – and then, on the other hand, once we get these antibody results, how we can find the utility in them or find them useful in taking care of our patients. At the same time, I also wanted to kind of highlight that these antibodies are not perfect, they do have certain limitations – so, that's another thing I sort of highlighted in the article.   Dr Monteith: So, why don't we just start with a very broad question - what do you believe the role of autoantibodies is in the workup of neuropathies and then neuromuscular disorders? Obviously, when we think of myasthenia gravis, but there are some presentations that you may not necessarily think to first order autoantibody tests. So, what is the role, and where does it fit in the paradigm?   Dr Dubey: I think it's extremely crucial, and it's evolving as time goes on, and it's becoming more and more clinically relevant. Let's say three, four decades ago, the number of biomarkers which were available were very limited and only a handful - and there has been a significant increase in these biomarkers with growing utilization of newer techniques for discovery of antibodies, and more and more people jumping into this field trying to not only discover, but try and understand and validate these biomarkers (what they truly, clinically mean). These antibodies, like you pointed out, ones for myasthenia (such as acetylcholine receptor-binding antibodies, or MuSK antibodies), they can be extremely helpful in clinical diagnosis of these patients. We all know the importance of EMG in managing our patients with neuromuscular disorders. But, oftentimes, EMG nerve conduction studies are often not available at every center. In those scenarios, if you have antibodies with very high clinical specificity, and you're seeing a patient on examination whom you're seeing ptosis (fatigable ptosis), double vision, you're suspecting myasthenia, you send antibodies, and they come back positive. It brings you closer to the answer that may, in turn, require you to refer to a patient to a place where you can get high-quality EMGs or high-quality care. In addition to getting to the diagnosis, it also, sometimes, leads you in directions to search for what is the trigger. A good example is all these paraneoplastic neurological syndromes (which we started our conversation with), where once you find a biomarker (such as anti-Hu antibodies or CRMP5 antibodies) in a patient with paraneoplastic neuropathies, it can direct the search for cancer. These are the patients where, specifically, these two antibodies, small-cell lung cancer is an important cancer to rule out - they require CT scans, and if those are negative, consider doing PET scan – so, we can remove the inciting factor in these cases. And then, lastly, it can guide treatment. Depending upon subtypes of antibodies or particular antibodies, it can give us some idea what is going to be the most effective treatment for these patients.   Dr Monteith: I think paraneoplastic syndromes are a very good example of how autoantibodies can help guide treatment. But, what other examples can you provide for us?   Dr Dubey: Yeah, so I think one of the relatively recent antibody tests which our lab started offering is biomarkers of autoimmune neuropathies - these are neurofascin and contactin, and those are great examples which can target or guide your treatment. I personally, in the past, have had many CIDP patients before we were offering these testings, where we used to kind of start these patients on IVIG. They had the typical electrodiagnostic features, which would qualify them for CIDP. They did not show any response. In many of these cases, we tried to do sort of clinical testing or sort of research-based testing for neurofascin and contactin back in the day, but we didn't have this resource where we can sort of send the blood, hopefully, and within a week, get an answer, whether these patients have autoimmune neuropathy or not. Having this resource now, in some of these cases, even before starting them on IVIG, knowing that test result can guide treatments, such as considering plasma exchange up front as a first-line therapy, followed by rituximab or B-cell depleting therapies, which have been shown to be extremely beneficial in these conditions. And it is not just limited to neurofascin or contactin (which are predominantly IgG4-mediated condition), but the same concept applies to other IgG4-mediated diseases, such as MuSK myasthenia, where having an antibody result can guide your treatment towards B-cell depleting therapies instead of sort of trying the typical regimen that you try for other myasthenia gravis patients.   Dr Monteith: And you mentioned where I was reading that, sometimes, nerve conduction studies and EMG can be useful to then narrow the autoantibody profiles. Oftentimes, in the inpatient service, we order the autoantibodies much faster, because it's sometimes harder to access EMG nerve conduction studies - but talk about that narrowing process.   Dr Dubey: Yeah. And it goes back to the point you just made where we end up sending, sort of, sometimes (and I'm guilty of this as well), where we just send antibodies incessantly, even knowing that this particular patient is not necessarily likely to be an autoimmune neurological disorder, and that can be a challenge, even if the false-positive rate for a particular test is, let's say 1% - if you send enough panels, you will get that false-positive result for a particular patient. And that can have significant effects on the patient - not only unnecessary testing or imaging (depending on what type of antibody it is), but also exposure to various immunotherapies or immunosuppressive therapies. It's important to recognize red flags – and that's one of the things I've focused on in this article, is talking about clinical, as well as electrodiagnostic, factors, which make us think that this might be an autoimmune condition, and then, subsequently, we should consider autoantibody testing. Otherwise, we can be in a situation - that 1% situation - where we may be sort of dealing with a false-positive result, rather than a true-positive result. In terms of EMGs, I think I find them extremely useful, specifically for neuropathies, distinguishing between demyelinating versus exonal, and then catering our antibody-ordering practices toward specific groups of antibodies which are associated with demyelinating neuropathies (if that's what the electrophysiology showed) versus if it's an exonal pathology (considering a different subset of antibodies) - and that's going to be extremely important.   Dr Monteith: You're already getting to my next question, which is what are some of the limitations of autoantibody testing? You mentioned the false-positivity rate - what other limitations are there?   Dr Dubey: So, I think the limitations are both for seropositive, as well as seronegative, patients. As a neurologist, when we see patients and send panels, we can be in a challenging situation in both of those scenarios. Firstly, thinking about seropositives - despite the growing literature about neurology and antibodies, we have to be aware, at least to some extent, about what methodologies are being utilized for these antibody tests. And what I mean by that is knowing when you're sending a sample to a particular lab, the methodology that they're utilizing - is that the most sensitive, specific way to test for certain antibodies? We've learned about this through some of the literature published regarding MOG and aquaporin-4, which has demonstrated that these antibodies, which we suspect are cell surface antibodies, not only generate false-positive, but also false-negative results if they are tested by Western blots or ELISAs. Similar can be applied to some of the cell surface antibodies we are investigating on the autoimmune neuromuscular side (we have some sort of unpublished data regarding that for neurofascin-155). Secondly, it's also kind of critical when you're getting these reports to kind of have a look at what type of secondary antibodies are being utilized, an example being we talked about neurofascin-155, and I mentioned these are IgG4-predominant diseases, so testing for neurofascin IgG4 and knowing that particular patient is positive IgG4 rather than neurofascin pan-IgG. That's an important discrimination, and important information for you to know, because we have seen, at least in my clinical practice, that patients who are positive for neurofascin IgG4 follow the typical story of autoimmune neuropathies - the ones who are not (who are just neurofascin-155 IgG-positive), oftentimes can have wide-ranging phenotypes. The same applies to neurofascin-155 IgMs. And then (not for all antibodies, but for some antibodies), titers are important. A good example of that is a3 ganglionic receptor antibodies, which we utilize for when we're taking care of patients who have autoimmune dysautonomia - and in these cases, if the titers of the antibodies are below .2 nmol/L, usually, those don't have a high specificity for AAG diagnosis. So, I get referred a lot of patients with very low titers of a3 ganglionic receptor antibodies, where the clinical picture does not at all look like autoimmune autonomic ganglionopathy. So, that's another thing to potentially keep in mind. And then, on the seronegative front, it's important to recognize that we are still sort of seeing the tip of the iceberg as far as these antibodies or biomarkers are concerned, specifically for certain phenotypes, such as CIDP. If you look at the literature, depending upon what demographics we're looking at or sort of racial profiles we're looking at, the frequency of these autoimmune neuropathy biomarkers range from 5% to 20%, with much higher frequency in Asian patients - so, a good chunk of these diseases are still seronegative. In the scenario where you have a very high suspicion for an autoimmune neuromuscular disorder (specifically, we'll talk about neuropathies, because that's why we utilize tissue immunofluorescence staining on neural tissues), I recommend people to potentially touch base with that tertiary care lab or that referral lab to see if they have come across some research-based antibodies which are not clinically validated, which can give you some idea, some additional supportive idea, that what you're dealing with is an autoimmune neuromuscular disorder. So, we have to keep the limitations of some of these antibody panels and antibody tests in mind for both positive, as well as negative, results.   Dr Monteith: So, you've already given us a lot of good stuff, um, about titer seronegativity and false-positive rates. And, you know, also looking at the clinical picture when ordering these tests, utilizing EMG nerve conduction studies, give us a major key point that we can't not get when reading your article.   Dr Dubey: I think the major key point is we are neurologists first and serologists later. Most of these patients, we have to kind of evaluate them clinically and convince ourselves at least partly that this might be an autoimmune neuromuscular disorder before sending off these panels. Also, I find it useful to narrow down the phenotype, let's say, in a particular neuropathy or a muscle disease or a hyperexcitability syndrome. So, I have a core group of antigens, autoantigens, or autoantibodies, which I'm expecting and making myself aware of - things beyond that will raise my antenna - potentially, is this truly relevant? Could this be potentially false-positive? So, clinical characterization up front, phenotypic characterization upfront, and then utilizing those antibody results to support our clinical decision-making and therapeutic decision-making is what I've tried to express in this article.   Dr Monteith: And what is something that you wish you knew much earlier in your career?   Dr Dubey: It's a very challenging field, and it's a rapidly evolving field where we learn many things nearly every year, and, sometimes, we learn things that were previously said were incorrect, and we need to kind of work on them. A good example of that is initial reports of voltage-gated potassium-channel antibodies. So, back in the day when I was actually in my medical school and (subsequently) in my residency, voltage-gated potassium-channel antibodies were closely associated with autoimmune neuromyotonia, or autoimmune peripheral hyperexcitability syndromes. Now, over time, we've recognized that only the patients who are positive for LGI1 or CASPR2 are the ones who truly have autoimmune neuromuscular disorders or even CNS disorders. The voltage-gated potassium-channel antibody by itself, without LGI1 or CASPR2, truly doesn't have a very high specificity for neurological autoimmunity. So, that's one example of how even things which were published were considered critical thinking or critical knowledge in our field of autoimmune neuromuscular disorders has evolved and has sort of changed over time. And, again, the new antibodies are another area where nearly every year, something new pops up - not everything truly stands a test of time, but this keeps us on our toes.   Dr Monteith: And what's something that a patient taught you?   Dr Dubey: I think one of the things with every patient interaction I recognize is being an autoimmune neurologist, we tend to focus a lot on firstly, diagnosis, and secondly, immunotherapy - but what I've realized is symptomatic and functional care beyond immunotherapy in these patients who have autoimmune neurological disorders is as important, if not more important. That includes care of patients, involving our colleagues from physical medicine and rehab in terms of exercise regimen for these patients as we do immunotherapies, potentially getting a plan for management of associated pain, and many other factors and many other symptoms that these patients have to deal with secondary to these autoimmune neurological conditions.   Dr Monteith: I think that's really well said, because we get excited about getting the diagnosis and then getting the treatment, but that long-term trajectory and quality of life is really what patients are seeking.   Dr Dubey: Yeah, and as you pointed out, most of the time, especially when we are in inpatient service, or even when we're seeing the patients upfront outpatient, we are seeing them, sometimes, in their acute phase or at their disease not there. What we also have to realize is, what are the implications of these autoimmune neurological conditions in the long term or five years down the line? And that's one of the questions patients often ask me and how this can impact them even when the active immune phase has subsided - and that's something we are actively trying to learn about.   Dr Monteith: So, tell me something you're really excited about in your field.   Dr Dubey: I think, firstly (which is pretty much the topic of my entire article), is novel antibodies and new biomarker discoveries. That's very exciting - we are actively, ourselves, involved in the space. The second thing is better mechanistic understanding of how these antibodies cause diseases, so we can not only understand diseases, we can also try and understand how to target and treat these diseases - this is being actively done for various disorders. One of the disorders which continue to remain a challenge are T-cell mediated diseases, where these antibodies are just red flags or biomarkers are not causing the disease, but it's potentially the T-cells possibly attacking the same antigen which are causing disease process, and those are often the more refractory and harder-to-treat conditions. I'm hoping that with some of the work done in other fields (such as rheumatology or endocrinology for type one diabetes), we're able to learn and apply the same in the field of autoimmune neurology and autoimmune neuromuscular medicine. And then, the final frontier is developing therapies which are antigen specific, where you have discovered that somebody has a particular antibody, and if that antibody is pathogenic, can I just deplete that antibody, not necessarily pan-depleting the immune system. And there is some translational data, there's some animal model data in that area, which I find very exciting, will be extremely helpful for many of my patients.   Dr Monteith: So, very personalized targeted therapies?   Dr Dubey: Correct. Without having all the side effects we all have to kind of take care of in our patients when we start them on, let's say, cyclophosphamide, or some of these really, really, significantly suppressive immunosuppressive medications.   Dr Monteith: Well, thank you so much. I learned a lot from reading your article to prepare for this interview, but also just from talking to you. And it's clear that you're very passionate about what you do and very knowledgeable as well, so, thank you so much.   Dr Dubey: Thank you so much. Thank you for inviting me to do this. And thank you for inviting me to contribute the article.   Dr Monteith: Today, I've been interviewing Dr Divyanshu Dubey, whose article on autoimmune neuromuscular disorders associated with neural autoantibodies appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining us today.   Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information, important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

Entenda essa doença que pode afetar o fígado e vias biliares. Neste episódio, eu explico as causas, diagnóstico e tratamento da doença relacionada a IgG4. Médica Hepatologista Dra. Raquel Scherer de Fraga - CREMERS 24.280 / RQE 23338 Assista minhas lives todas as terças-feiras, às 20h, no Instagram! Acompanhe meu trabalho nas redes sociais: Instagram, Facebook e YouTube. Acompanhe também meu site https://draraquel.com.br/

Send us a Text Message.In this FRIDAY 5 episode of “The Autoimmune RESET,” VJ explores the essential markers that every comprehensive food reactivity test should include. Join your host, VJ Hamilton, as we break down the roles of IgG, IgG4, IgA, IgE, and Complement in uncovering hidden food sensitivities. Whether you're dealing with unexplained symptoms, managing an autoimmune condition, or simply curious about how food affects your health, these five markers provide crucial insights into your body's responses. Learn how understanding these markers can help tailor your diet, reduce inflammation, and improve your well-being. Tune in to discover how a deeper look at food sensitivities can transform your health journey.Have questions or comments? Connect with us on social media or visit our website at www.theautoimmunitynutritionist.com for more resources and information.You can learn more about food intolerances, sensitivities and allergies in this article. And if you would like to learn more about the P88 antigen reactivity screen, you can find out more here. Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

In this episode, Dr Yik Man talks to Prof David D'Cruz about IgG4 related disease, including an approach to management and some tricky cases.

Nurses Out Loud with Jodi O'Malley MSN, RN – I debunk myths around 'hybrid' immunity and vaccine-induced IgG4 responses. The classification of the COVID-19 vaccine sparks debate, with experts challenging its efficacy. I explore "hybrid" immunity, the controversial term in immunology, and the shift towards IgG4 antibody production, questioning the long-term protection offered by mRNA vaccines against COVID-19.

Nurses Out Loud with Jodi O'Malley MSN, RN – I debunk myths around 'hybrid' immunity and vaccine-induced IgG4 responses. The classification of the COVID-19 vaccine sparks debate, with experts challenging its efficacy. I explore "hybrid" immunity, the controversial term in immunology, and the shift towards IgG4 antibody production, questioning the long-term protection offered by mRNA vaccines against COVID-19.

This week we take you through a disease that can truly affect just about every organ system - IgG4 Related Disease. We will walk you through the presentation, work up, and approach to treatment Support the show

CardioNerds nerd out with Drs. Karishma Rahman (Mount Siani Vascular Medicine fellow), Shu Min Lao (Mount Sinai Rheumatology fellow), and Constantine Troupes (Mount Sinai Vascular Surgery fellow). They discuss the following case: A 20-year-old woman with a history of hypertension (HTN), initially thought to be secondary to a mid-aortic syndrome that resolved after aortic stenting, presents with a re-occurrence of HTN. The case will go through the differential diagnosis of early onset HTN focusing on structural etiologies of HTN, including mid-aortic syndrome and aortitis. We will also discuss the multi-modality imaging used for diagnosis and surveillance, indications and types of procedural intervention, and how to diagnose and treat an underlying inflammatory disorder leading to aortitis. The expert commentary was provided by Dr. Daniella Kadian-Dodov, Associate Professor of Medicine and Vascular Medicine specialist at the Icahn School of Medicine at Mount Sinai. Audo editing was performed by Dr. Chelsea Amo-Tweneboah, CardioNerds Academy Intern and medicine resident at Stony Brook University Hospital. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - Hypertension With a Twist Pearls - Hypertension With a Twist Early onset hypertension (HTN) and lower extremity claudication should raise suspicion for aortic stenosis (including mid-aortic syndrome). Initial evaluation should include arterial duplex ultrasound and cross-sectional imaging such as CT or MR angiogram of the chest, abdomen, and pelvis to assess for arterial stenosis involving the aorta and/or branching vessels. Mid-aortic syndrome can have multiple underlying etiologies. Concentric aortic wall thickening should raise suspicion for an underlying inflammatory disorder. Initial evaluation should include inflammatory markers such as ESR, CRP, and IL-6, but normal values do not exclude underlying aortitis.  While Takayasu arteritis is the most common inflammatory disorder associated with mid-aortic syndrome, IgG4-RD should also be a part of the differential diagnosis. IgG subclass panel can detect IgG4-RD with elevated serum IgG4 levels, but some cases can require pathology for diagnosis. Catheter based intervention is a safe and effective treatment of aortic stenosis for both primary aortic stenosis and post-procedural re-stenosis. Multi-modality imaging, including cross-sectional imaging and duplex ultrasound, plays a central role for the diagnosis, management, and post-procedural surveillance of aortic disease. A multi-disciplinary team (as exemplified by the participants of this podcast!) is essential for the management of complex aortopathy cases to optimize clinical outcomes. Show Notes - Hypertension With a Twist 1.  Early onset HTN can have multiple etiologies – aortic stenosis (including but not limited to secondary to congenital aortic coarctation and mid–aortic syndrome, as well as in stent re-stenosis if there is a history of aortic stenting), thrombosis, infection, inflammatory/autoimmune disorders, renovascular disease, polycystic kidney disease, and endocrine disorders. 2. Mid-aortic syndrome is characterized by segmental or diffuse narrowing of the abdominal and/or distal descending aorta with involvement of the branches of the proximal abdominal aorta (renal artery, celiac artery, superior mesenteric artery) and represents approximately 0.5 to 2% of all cases of aortic narrowing. Underlying etiologies include genetic syndromes, inflammatory, non-inflammatory, and idiopathic. It is important to have a high suspicion of underlying inflammatory disorders if cross-sectional i...

Join us this week for an in-depth discussion on IgG4-Related Disease with one of the premiere researchers in the field, Dr. John Stone. On this episode, Dr. Stone reviews the disease clinical presentation as well as its symptoms, how to make the diagnosis, treatment options, the role of IgG4 and what happens inside the body. Later, we discuss Dr. Stone's research along with his personal journey in the field. 

Dr. Evanoff, Cindy Wilinski and Mel return in 2024 to discuss the current state of Pandemic crisis as they dissect the anti-vaccine propaganda and discuss the IgG4 paper that has been misinterpreted and weaponized. --- Send in a voice message: https://podcasters.spotify.com/pod/show/projectcanary/message

Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours (12/13/23). As always, take the information discussed in the video below and research it for yourself, and come to your own conclusions. Anyone telling you what the truth is, or claiming they have the answer, is likely leading you astray, for one reason or another. Stay Vigilant. !function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/u2q643"+(arguments[1].video?'.'+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble");   Rumble("play", {"video":"v3yiqkb","div":"rumble_v3yiqkb"}); Video Source Links (In Chronological Order): Japan Approves World's First 'Self-Amplifying' mRNA COVID-19 Vaccine Without Published Efficacy Or Safety Data | ZeroHedge Self-Spreading Vaccines, Self-Amplifying mRNA Vaccines & COVID Vaccine Menstrual Disruption (11) Igor Chudov

God knows everything whispered in secret, and one day those things will be shouted from the rooftops. The people who run Biden, Tony Fauci being one of them, were whispering in the dark about the deaths and injuries from the mRNA injections. They knew. It's obvious how these injections were designed, that they would kill people. God knows their motives and 17 million people are most likely dead and will keep dying from these injections. We examine the state of things as we look at Britain, where a politician presents his concerns on the increased deaths following the pandemic to a 98% empty House of Commons. And in New Zealand, Liz Gunn spoke with a whistleblower about the deaths they are seeing as a consequence of the injections and how those in charge also knew about the adverse effects. What does God's Word say? Exodus 20:13“You shall not murder.”Galatians 6:7 Do not be deceived: God is not mocked, for whatever one sows, that will he also reap.Luke 12:3 3 What you have said in the dark will be heard in the daylight, and what you have whispered in the ear in the inner rooms will be proclaimed from the roofs.Which ones describes Fauci? ​​The War Within; Flesh Versus SpiritEpisode 1,179 Links:Step Right Up And Spend $10,000 To Get Your Picture Taken With Prolific Liar Anthony FauciMichigan judge denies drug manufacturer's immunity in case of contaminated COVID-19 medicationA mass iatrogenic event that killed 17 million (0.213%) of world population so far. That's the conclusion of a September 2023 study of 17 countries that covered 10% of world population. The average global death rate is about 0.8% per annum (about 67 million), so the iatrogenic event corresponds to about 25% of of the annual global death rate. Andrew Bridgen, @ABridgen MP of North West Leicestershire, is so far the only western hemisphere politician to debate this topic in a public setting, today (!) in the UK House of Commons, with an empty row of seats. The good news: global birth rate still hovers around 1.2% per annum, so we're still producing about 30 million net lives per year. Not so good news: the fertility rate is dropping perpendicularly, due to the same iatrogenic factor.Andrew Bridgen's opening statement to an empty House of CommonsNew @FDA pre-print study: Active surveillance system finds elevated risk of seizures in toddlers and myocarditis in teenagers associated with covid mRNA vaccination.More proof the mRNAs rewire the immune system with unknown long-term effects; The biggest study yet on post-jab IgG4 "class switching" just came out. You will be shocked - SHOCKED - to hear American researchers had nothing to do with it.EXCLUSIVE: American Academy of Pediatrics Named In Bombshell Detransitioner LawsuitYoung girl was "unfortunate victim of a collection of actors who prioritized politics and ideology over children's safety," lawsuit states45 Predators caught in sting operation targeting children including one who was a cannibal. These Predators knowingly have Sexually Transmitted Disease. Parents please keep a close eye on your children4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. American Financing https://americanfinancing.net Visit to see what American Financing can do for you or call 866-887-2275 BiOptimizers https://bioptimizers.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. Call 866-779-RISK or visit KnowYourRiskRadio.com Patriot Mobile https://patriotmobile.com/herman Get free activation today with offer code HERMAN. Visit or call 878-PATRIOT. SOTA Weight Loss https://sotaweightloss.com SOTA Weight Loss is, say it with me now, STATE OF THE ART! Sound of Freedom https://angel.com/freedom Join the two million and see Sound of Freedom in theaters July 4th. GreenHaven Interactive https://greenhaveninteractive.com Digital Marketing including search engine optimization and website design.

The Health Advocates are joined by Nika Beamon who lives with IgG4-related disease (IgG-RD), a group of fibroinflammatory conditions that can impact various tissues, often leading to tumor-like growth or organ dysfunction. Nika shares her 17-year journey to an IgG4-RD diagnosis, including how she advocated for herself. She offers valuable tips for fellow chronic illness patients, highlighting the unique considerations people with autoimmune diseases have in everyday life. “So there's so many things that do alter your life. But at the end of the day, you got one life, so you got to live it, and so I just choose to live it regardless of the fact that this is how it's built,” says Nika. Among the highlights in this episode:00:50: Nika gives an in-depth account of her health struggles, which began in college. She discusses her IgG4 symptoms like constant fatigue, joint pain, and spontaneous fevers, which baffled doctors for years 04:25: Nika emphasizes the importance of self-advocacy and the need for patients to have all their medical records organized 05:20: After years of suffering, a top rheumatologist identifies Nika's condition, marking a significant turning point in her journey 05:35: Zoe Rothblatt, Associate Director of Community Outreach at GHLF, asks about Nika's reaction to finally receiving a diagnosis, underscoring the emotional impact of living undiagnosed for such a long period 07:46: Nika delves into her decision to write about her health journey and shares her personal experience of opening up to coworkers, revealing the challenges of living with a hidden illness 09:14: Nika discusses the complexities of diagnosing autoimmune diseases and the significance of patients being proactive, keeping detailed records, and ensuring doctors are listening to their concerns 13:01: Zoe emphasizes the challenges of managing a chronic illness, including the constant advocacy required, the need for continuous learning, and the difficulties in communicating with doctors 14:00: Nika discusses her experiences during the pandemic, especially the disparity between how she and others perceived the impact of illnesses like COVID 18:34: Nika emphasizes the importance of advocacy, surrounding oneself with a supportive community, and recognizing the disease as just a part of oneself 20:02: What our hosts learned from this episode Contact Our Hosts Steven Newmark, Director of Policy at GHLF: snewmark@ghlf.org Zoe Rothblatt, Associate Director, Community Outreach at GHLF: zrothblatt@ghlf.org We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Catch up on all our episodes on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

The actions of local, state and federal government have killed many, and their culling may be the only thing that saves us; I discuss the first steps toward an attack on homeschooling; and I read from an article about IgG4 and what is happening and what will continue to happen.   IgG4 article: https://veryvirology.substack.com/p/igg4-antibody-class-switch-end-of?nthPub=91

Episode 2066 - IgG4 immune antibodies are a mess right now. Introducing the new Healthmasters.com web site. A pound of prevention is worth a 1000 pounds of cure. Another crocodile story. Aldi leading the cashless movement? Bill Barr downgrades the first amendment? Plus much much more.. More of a fireside chat today.

Today, I am blessed to have here with me, Spencer Feldman. He founded Remedylink, where he has been formulating and manufacturing detoxification products for doctors and their patients. He was raised in New York where he spent most of his life before deciding the Pacific Northwest was where he belonged. Spencer can do what he loves daily by creating products that support natural detoxification, thanks to his training in holistic health, chelation therapy, and detoxification. Spencer has shared his love of health for over 20 years through his longest-running suppository company in the country, with goods that reflect proper workmanship and a commitment to quality. In this episode, Spencer discusses the importance of a balanced diet and its impact on microbiome health. The best way to improve our overall health is by detoxification. Spencer reveals the effective and convenient alternatives for detox. Tune in as we chat about long-term carnivore or high-fat diets, lysosomes' role, cyclodextrins and probiotics, and detoxification in maintaining overall health and promoting graceful aging. Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [06:16] Histamine Receptors and Allergies: A New Perspective on Health Disorders Allergic reactions can be immediate or delayed. The latter, often called intolerances, can occur hours after exposure to an allergen and can be harder to identify due to this delay. Histamine receptors are found throughout the body, not only in typical locations like the skin, sinuses, and lungs. Therefore, allergic reactions can affect various bodily systems. Health issues like interstitial cystitis, plaque in the arteries, and neurological conditions may have allergic components, meaning they may be triggered or worsened by allergies or intolerances. It's crucial to identify and minimize exposure to allergens, which can come from various sources, such as food, to mitigate these adverse health effects. This can be done through allergy and intolerance tests. Understanding the broader impact of allergies can lead to better diagnoses and treatments for various health conditions that might have been previously unexplained.  [15:18] How Can You Manage Histamine Levels in Leftover Food? Check this out! Histamine, produced by bacteria, can accumulate in leftover food and may cause unpleasant reactions when consumed. This accumulation begins immediately after cooking and cannot be reversed by reheating. Refrigeration slows down histamine production by reducing bacterial activity. However, leftovers should be refrigerated immediately after cooking to limit histamine buildup effectively. Leftovers should be spread out rather than lumped in the fridge to speed up cooling and slow histamine buildup. This increases the surface area exposed to the cold temperature, helping the food cool down faster. Due to the potential histamine buildup in stored food, sensitive or reactive people may need to avoid leftovers until their condition is controlled. [17:37] What's the Effect of Vaccines on the Immune System that Makes a Significant Health Challenge? Long-term COVID-19 is linked to IgG4 disease, characterized by an immune system overreaction leading to tissue swelling and fibrosis. This previously rare condition is now seen more frequently due to the COVID-19 pandemic and related vaccines. Vaccines can trigger an immune response that produces spike proteins indefinitely, leading to continuous inflammation and fibrosis. This response lacks an "off switch," which presents a significant health challenge. To help manage this ongoing reaction, proteolytic enzymes, such as natto kinase and serrapeptase, may break down the spike proteins and fibrosis. Over time, lysosomes, the cellular "recycling centers," can become overwhelmed with proteins they cannot break down and gradually transform into "landfills." This shift may be a primary factor behind accelerated aging. The key to managing long-term health effects, particularly in COVID-19, is to support the body's protein digestion mechanisms and clean out lysosomes, potentially slowing the aging process.  [26:16] What Dietary Adaptation Techniques Are Useful Over the Long Term?  If you have a histamine problem, you can make significant improvements by modifying your environment and diet. Still, structural damage caused by inflammation from histamine may take longer to heal. Food reactivity is a spectrum, not a binary state. Some may be highly allergic to certain foods but only mildly reactive to others. Begin reintroduction with foods you are mildly reactive to. Over time, humans have selectively cultivated plants to have fewer toxins (anti-nutrients) and more desirable traits like sweetness. This has pros and cons, including the loss of some beneficial anti-nutrients. Some anti-nutrients can have medicinal value and defend against viruses, fungi, parasites, bacteria, and even cancer. Knowing which plants to avoid is crucial due to their high content of harmful anti-nutrients, like soy and spinach, which can harm our thyroid function and cause conditions such as kidney stones. A general guideline is to stay away from oxalates. [36:26] What's the Importance of Raw Meat and Protein? Raw meat contains a variety of proteins and peptides, which could be beneficial for anti-aging and overall health, which may be altered or reduced during the cooking process. Cooking meat releases glutamate, a flavor-enhancing amino acid, which can cause adverse reactions in some individuals, such as headaches or shaking. The cooking process can also lead to the creation of glycation products which can contribute to aging and other health issues. To mitigate the formation of glycation products during cooking, marinate your meat and cook with some acid, such as lemon juice. Recognize your sensitivity to glutamate. If you're not sensitive, you may only need to reduce your consumption of high-glutamate foods. If you are sensitive, more drastic dietary changes may be required for your well-being.  [42:10] What's the Role of Olive Oil in Nutrient Delivery and Fuel Source? While olive oil has many health benefits due to its oleocanthal and polyphenols content, it does not necessarily negate its glycation content. Olive oil should be used in moderation, not as a main fuel source but as a nutrient delivery mechanism. This supports the absorption of fat-soluble nutrients from other foods. Balancing the intake of different food groups like low glycemic grains, beans, and fats can provide a more balanced energy source. Individuals who consume large amounts of oil may need to increase their protein intake accordingly. It's important to protect the lysosomes, cellular components involved in waste disposal, especially when consuming large quantities of a particular food. [51:53] What Are the Benefits of The Carnivore Diet? The microbiome plays a significant role in overall health and requires prebiotics for optimal function, found primarily in plant-based foods. Carnivore diets may be short-term beneficial but can lead to a lack of necessary prebiotics over time. Introducing a range of plant-based foods gradually can maintain a healthy microbiome. Lysosomes, the organelles in cells responsible for digesting fats and proteins, can become overloaded by misfolded proteins and hydrogenated fats, leading to neurologic conditions. Regular detoxification of metals and minimizing intake of misfolded proteins and hydrogenated fats can help maintain lysosomal health and aid graceful aging. Introducing substances like cyclodextrins can help maintain lysosomal health by clearing out hydrogenated fats and misfolded proteins, especially for individuals following high-fat diets like keto or carnivore diets. AND MUCH MORE! Resources from this episode:  Website: https://remedylink.com/ Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

– Dette er ikke en vaksine som skaper immunsvar, det er kroppen selv som produserer et genprodukt som genererer et immunsvar. Men det kan også levere en hel del andre ting.  Birger Sørensen er vaksineforsker og styreleder i vaksineselskapet Immunor. SARS-viruset er blant hans spesialfelt. Sørensen er blant dem som kan mest om SARSCov2 i Norge, særlig i USA har han lang erfaring fra bakgrunnsforskning innen sekvensstruktur og spikeprotein. Sørensen kaller ikke mRNA-produktet for vaksine. –Jeg beskriver det som et produkt med immunmodelererende effekt.  Vi vet nå at det fordeler seg i kroppen på en uvanlig måte. Det distribueres i hele kroppen, til forskjell fra normale vaksiner som dreneres til nærmeste lymfesystem. – Produktet kan gå til et hvilket som helst organ, inklusiv hjernen og hjertet, og det varierer hvor lenge det forblir der. Fra dager til måneder. Genproduktet havner i vev der det ikke skulle være.   Sørensen mener at myndighetene og media har sviktet.  – Myndighetene sørget ikke for at en «medisinsk revisor» vurderte dataene etter at massevaksineringen startet. Slik hoppet de bukk over reglene. Det er ellers uhørt at et firma lanserer en vaksine og presenterer egne data uten oppfølging og uten at de blir inspisert av en uavhengig tredjepart. Om det hadde blitt gjort, ville det gitt et annet datagrunnlag for sikkerhet. Legemiddelverket kan ha andre interesser enn en uavhengig tredjepart som viser faktiske funn.  – Og media har sviktet ved at det ikke er stilt kritiske spørsmål til produktet eller til massevaksineringen.  Hør Birger Sørensen i Hemalipodden om:Myndighetene må ha visst at de færreste har risiko ved covid-19-sykdom. FHIs forskere har ikke frihet til å kritisere.mRNA er et eksperimentelt genprodukt som ikke har holdt seg lokalt i kroppen.– Vi vet ikke om, og i så fall hvilken, effekt produktet har på ufødte barn eller på fertilitet. Forskning av høy standard med kritiske funn av mRNA-produktet blir ikke publisert. – Vitenskapelige journaler aksepterer ikke forskning som ikke passer med det offisielle bildet. Data om bivirkninger forsvinner på grunn av kriteriene for rapportering. Gjentatte doser av mRNA gir overproduksjon av immunoglobulin klasse IgG4, som kan skape immuntoleranse som svekker generell beskyttelse. Én konsekvens er at antistoffer som beskytter mot sykdom hindres i å «gjøre jobben sin». – Det kan gi autoimmune sykdommer som psoriasis og leddgikt. Forundret over stillheten fra fagfolk.Tvangsvaksinering er en reell problemstilling.       

A new, recently published study found that the more COVID-19 shots a person received, the more weakened their immune system becomes. The researchers laid out within the study the mechanism by how this happens, which has to do with the spike in production of IgG4 anti-bodies within the vaccine recipient's body. A new body of research has recently discovered that these IgG4 anti-bodies are not benign, but can lead to a plethora of problems for the human body, including cancer, organ dysfunction, organ failure, and even death. The technical name for this is IgG4-Related Disease. ⭕️ Sign up for our NEWSLETTER and stay in touch

A new, recently published study found that the more COVID-19 shots a person received, the more weakened their immune system becomes. The researchers laid out within the study the mechanism by how this happens, which has to do with the spike in production of IgG4 anti-bodies within the vaccine recipient's body. A new body of research has recently discovered that these IgG4 anti-bodies are not benign, but can lead to a plethora of problems for the human body, including cancer, organ dysfunction, organ failure, and even death. The technical name for this is IgG4-Related Disease. ⭕️Watch in-depth videos based on Truth & Tradition at Epoch TV

Dr. Jack Cush reviews the news and reports from the past week on RheumNow.com. This week a new colchicine FDA approval, rising rate of IgG4 related disease and what's the safest biologic?

5 questions for the GIRL Joe Biden's bosses chose to run the CDC and why The Party needs Walensky clones.You probably observe the same pattern: so-called “public ‘health'” officials are one of two types of people: evil and scheming or compliant supplicants to evil and scheming. Is this nature of nurture? I think it's both. Our medical schools are co-opted by pharma, the public health system is co-opted by pharma, our CDC and FDA ARE pharma. They all nurture well meaning young people into becoming either evil and scheming or compliant servants of evil schemers. This has never been more clear than in the case of the girl--and, she is quite clearly too immature to be called a woman--whom the people who run Joe Biden want as the FigureHead over the CDC. Oh . . . if people think this is just about Covid, please let me remind you that this girl and people like her are the same people who will be told to approve brain implants in people, mRNA in food supplies, mosquitoes spreading mRNA against people's wishes and more. This is the battlefront. Why were you laughing and giggling with your girlfriend about shutting down the American economy?Are you capable of restoring trust? Are you capable of telling the truth? Exactly how many HEALTHY kids who had NO comorbid conditions died from Covid? Why should anyone believe you -- for instance, can you name one, single factor you got right about Covid, masks, injections or lockdowns? What does God's Word say? Proverbs 6:16-19 There are six things that the Lord hates, seven that are an abomination to him: haughty eyes, a lying tongue, and hands that shed innocent blood, a heart that devises wicked plans, feet that make haste to run to evil, a false witness who breathes out lies, and one who sows discord among brothers.Psalm 37:1-40Fret not yourself because of evildoers; be not envious of wrongdoers! For they will soon fade like the grass and wither like the green herb. Trust in the Lord, and do good; dwell in the land and befriend faithfulness. Delight yourself in the Lord, and he will give you the desires of your heart. Commit your way to the Lord; trust in him, and he will actEpisode 874 Links:New CDC Director Mandy Cohen recalls how she and her colleagues came up with COVID mandates during her time as NC Health Director. “She was like, are you gonna let them have professional football? And I was like, no. And she's like, OK neither are we.”By the way, Mandy Cohen apparently only masks when there's a camera around. Here she walked into the press conference unmasked, not realizing a camera caught it. This was June 30, 2020, a couple months before she tweeted the photo of the Fauci mask.Fauci and Pfizer Lied to Trump About COVID-19 Vaccine, Claims NavarroOur 1st COVID-19 mRNA vaccine paper was accepted & went viral! mRNA vaccines make IgG4 which suppresses the immune system, causing COVID re-infections, autoimmune diseases (myocarditis) & cancer!Family of College Student Who Died From COVID-19 Vaccine Sues Biden AdministrationSo-called ‘Gender-Affirming' Surgery Leaves People Lonelier and Depressed, Study by Transgender Surgery Department Chairman FindsForget all the complex arguments explaining why we must resist the WHO treaty amendments. All you need to know is who'll be in charge of the WHO's Behavioural Insights team enforcing future lockdowns & vaxx mandates - without our Govt consent Elon Musk's Brain Implant Firm Says U.S. Has Approved Human TestsUS air force denies running simulation in which AI drone ‘killed' operator; Denial follows colonel saying drone used ‘highly unexpected strategies to achieve its goal' in virtual test4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. BiOptimizers https://magbreakthrough.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. Call 866-779-RISK or vist KnowYourRiskRadio.com Healthycell http://healthycell.com/todd Protect your heart with Healthycell! Use promo code TODD for 20% off your first order. My Pillow https://mypillow.com Use code TODD for BOGO on the new MyPillow 2.0 Patriot Mobile https://patriotmobile.com/herman Get free activation today with offer code HERMAN. Visit or call 878-PATRIOT. RuffGreens https://ruffgreens.com/todd Get your FREE Jumpstart Trial Bag of Ruff Greens, simply cover shipping. Visit or call 877-MYDOG-64. SOTA Weight Loss https://sotaweightloss.com SOTA Weight Loss is, say it with me now, STATE OF THE ART! GreenHaven Interactive https://greenhaveninteractive.com Digital Marketing including search engine optimization and website design.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5674544/advertisement

In this episode, Tiffany will discuss how different organs can be impacted by the disease and the difference between an organ being part of a disease and being a comorbidity. Tiffany will be exploring some examples of organs being affected in various diseases such as eyes, heart, gastrointestinal, and kidneys, as well as a newer autoimmune disease, IgG4, that is commonly being diagnosed for patients alongside their AiArthritis disease. It is crucial for patients to be proactive in their healthcare by asking their healthcare provider about organ involvement - as part of their disease or as a potential comorbidity- and what steps they can take to next manage their health. This episode is just the start of this conversation! Tiffany will be joined by Eileen and Deb at EULAR 2023 in Milan, Italy, as part of our “Go With Us!” To Conferences program. While there we will be recording updates for you from all sessions that cover this topic, which will be available soon after on our YouTube channel/Go With Us! to EULAR 2023 playlist.  Want to get insider information from our visit to EULAR 2023 and first notification of new materials we create from attending? Sign up at https://www.aiarthritis.org/conferences Share your AiArthritis disease comorbidities questions with us here! info@aiarthritis.org Subject: Comorbidities   Episode Highlights:  Understanding the complexities of comorbidities with AiArthritis diseases  Sharing the different comorbidities that commonly occur with AiArthritis diseases  Learn which organs are commonly affected by comorbidities and what your risks are  Understand IgG4, a newer autoimmune disease more and how it may be diagnosed alongside AiArthritis diseases  How to attend conferences with AiArthritis and learn more about comorbidities  Learn more about your AiArthritis disease by joining us at conferences, sharing your questions, joining AiArthritis Voices service or participating in the AiArthritis Research Database Our Co-Hosts: Tiffany is the CEO at International Foundation for AiArthritis and uses her professional expertise in mind-mapping and problem solving to help others, like her, who live with AiArthritis diseases work in unison to identify and solve unresolved community issues. Connect with Tiffany: Facebook: @TiffanyAiArthritis Twitter: @TiffWRobertson LinkedIn: @TiffanyWestrichRobertson   Donate to Support the Show: https://www.aiarthritis.org/donate    Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE   AiArthritis Voices 360 is produced by the International Foundation for Autoimmune and Autoinflammatory Arthritis. Visit us on the web at www.aiarthritis.org/talkshow. Find us on Twitter, Instagram, TikTok, or Facebook (@IFAiArthritis) or email us (podcast@aiarthritis.org).  Be sure to check out our top-rated show on Feedspot! 

Osteoarthritis (OA) is the most common form of arthritis. There are currently no effective disease-modifying treatments available to slow or reverse the progression of OA. Drugs such as metformin, which is commonly used to treat type 2 diabetes are generally safe and low cost. Research has been shown that metformin has anti-inflammatory and pro-weight loss effects, suggesting that the use of metformin may be useful in the treatment or prevention of OA. Dr Matthew Baker joins us on this week's episode of Joint Action to discuss this important topic. Dr. Matthew Baker is the Clinical Chief in the Division of Immunology and Rheumatology at Stanford University. He received his bachelor's degree from Pomona College, his medical degree from Harvard Medical School, and his master's degree in Epidemiology and Clinical Research from Stanford University. He completed his Internal Medicine residency at the Massachusetts General Hospital and his Rheumatology fellowship at Stanford University. Dr. Baker has established a clinical research program that is focused on clinical trials, epidemiological studies, and bench-to-bedside translational research. He has designed and led investigator-initiated and industry sponsored clinical trials with a focus on sarcoidosis, IgG4-related disease, and rheumatoid arthritis. In addition, he is the Co-Director of the Stanford Multidisciplinary Sarcoidosis Program and collaborates with other team members to advance sarcoidosis clinical care and research.RESOURCESDevelopment of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a SulfonylureaIncreased risk of osteoarthritis in patients with atopic diseaseCONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgEmail: hello@jointaction.infoWebsite: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review! Hosted on Acast. See acast.com/privacy for more information.

Ekspertepisode. Gjest: Øyvind Midtvedt, overlege ved Revmatologisk avdeling, Rikshospitalet.(Første sesong av podcasten er muliggjort gjennom et stipend fra Norsk revmatologisk forening) Hosted on Acast. See acast.com/privacy for more information.

Are you a nutritional therapist or nutrition professional - you'll love the new IHCAN magazine Podcast.Presented by the wonderful nutritional therapist Kirsten Chick, we'll bring you IHCAN content you know and love in easily digestible 45 minute episodes, perfect to listen to on a commute, a dog walk, while cooking or in-between clients.In this episode we speak to Dr Cheryl Burdette.Dr Cheryl Burdette is a naturopathic doctor and educator, and co-founder of the Precision Point Diagnostics laboratory. We take a deep dive into the immune system in the gut, which Cheryl describes beautifully, fluidly spanning microbes, neurotransmitters, secretory IgA and zonulin, alongside tribal immunity, long covid, autoimmune conditions and eating too much turkey. Followed by some detailed insights into new tests to figure out food allergies and intolerances, in particular around how to interpret IgG4, and then how to work on improving the situation.When asked what she loves most about what she does, Cheryl replies:“I love that we give people more hope... when we get to talk to people about things like dietary change that they can do themselves, it puts the power back in their own hands to seek more wellness. I don't think that we're all out there trying to eat a perfect diet to win the trophy. To say I ate more greens than anyone else. I think we do this because it allows us to live our passion.”--Dr Cheryl Burdette headlines the first virtual IHCAN Conference on Saturday 22 April with her talk 'Unraveling the Mysteries of Managing the Histaminergic Load'. SAVE an extra £5 on our early-bird rates using coupon code PODCAST at checkout - www.ihcanconferences.co.uk/april-2023. Valid for new bookings only.--Enjoyed the pod? Sign up here to be alerted everytime an episode is published: www.ihcan-mag.com/podcastInterested in sponsorship/advertising opportunities? We have options for all budgets. Email sales@targetpublishing.com--The IHCAN magazine Podcast is provided for professional education and debate and is not intended to be used by non-medically qualified individuals as a substitute for, or basis of, medical treatment.

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Tangled web of wires (Nature) Path to group A Streptococcus vaccines (Clin Inf Dis) Immune end-types predictive of vaccine responses (Nat Immunol) IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol) Very bad B cells (Immunity) Two epitope Streptococcus monoclonal (EMBO Mol Med) Predictor of vaccine-induced antibody responses (Nat Immunol) Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med) Neutrophilic inflammation and RSV infection (Science) Commensals avoiding recognition (Sci Immunol) Continuous germinal center invasion and immune response diversity (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

CardioNerds Cofounder Dr. Amit Goyal join Dr. Usman Hasnie and Dr. Will Morgan from University of Alabama at Birmingham for a hike up Red Mountain. They discuss the following case: A 75-year-old woman with prior mitral valve ring annuloplasty presented with subacute, intermittent, self-limiting neurologic deficits. Brain MRI revealed multiple subacute embolic events consistent with cardioembolic phenomena. Transesophageal echochardiogram discovered a mobile mass on the mitral valve as the likely cause for cardioembolic stroke. She was taken for surgical repair of the mitral valve. Tissue biopsy confirmed that the mass was an IgG4-related pseudotumor. Expert commentary is provided by Dr. Neal Miller (Assistant Professor of Cardiology, University of Alabama at Birmingham). Audio editing by CardioNerds Academy Intern, student doctor Adriana Mares Check out this published case report here: IgG4-Related Disease Masquerading as Culture-Negative Endocarditis! CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Cardioembolic Stroke due to an IgG4-related pseudotumor Surgical indications for endocarditis include severe heart failure, valvular dysfunction with severe hemodynamic compromise, prosthetic valve infection, invasion beyond the valve leaflets, recurrent systemic embolization, large mobile vegetations, or persistent sepsis (in infective endocarditis) despite adequate antibiotic therapy. IgG4 related disease is rare, and likely underrecognized due to the lack of reliable biomarkers. Biopsy and histologic confirmation are imperative to clinch the diagnosis. Cardiac manifestations of IgG4-related disease are rare but are often related to aortopathies. Valvular disease is extremely rare as a manifestation of the disease. Treatment of IgG4 related disease includes steroids as the first line treatment. IgG4 related disease requires a multi-disciplinary approach to both diagnose and treat. Show Notes - Cardioembolic Stroke due to an IgG4-related pseudotumor Notes were drafted by Dr. Hasnie and Dr. Morgan IgG4-related disease has a very diverse presentation including mimicry of infection, malignancy and other autoimmune conditions. It is a fibroinflammatory condition that results in deposition of IgG4 positive plasma cells. It has been described in multiple organ systems including the pancreas, kidneys, lungs and salivary glands.  Cardiac manifestations are extremely rare and valvular disease even more so. There are thirteen cases of IgG4 related valvular disease, and of these only two had mitral valve involvement such as this case. The most commonly reported cardiovascular manifestations are related to aortopathies.  This disease remains poorly understood at this point. There are no true biomarkers that can be used to risk stratify the diagnosis for clinicians. Biopsy is imperative to the diagnosis. Even serum IgG4 levels are normal in 30% of cases despite meeting histologic criteria on biopsy making the diagnosis incredibly difficult to make.  While guidelines have not been developed to guide treatment of IgG4-related disease, steroids are considered the first line treatment option for patients. Often times dosing is 2-4 weeks with a prolonged taper. When looking for glucocorticoid sparing agents, azathioprine, mycophenolate mofetil, and methotrexate are considered alternatives.  References - Cardioembolic Stroke due to an IgG4-related pseudotumor 1. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4- related autoimmune disease. J Gastroenterol 2003;38:982-4.  2. Deshpande V, Zen Y, Chan JK, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-1192. doi:10.1038/modpathol.2012.72  3. Dahlgren M,

Bear with us on this pod, as even the tangents we take have tangents of their own. A bit of a ramble, in this edition Andrew goes dark early, and we talk about the possibility of everyone dying who's taken the experimental gene therapies. What about the new evidence on IgG4 antibodies and original antigenic... The post Tangents on tangents on tangents appeared first on sounding board.

Dr. Prather opens the show with two segments dedicated to our "Health Freedom Update". Then, we talk about why having a Health Coach is important to help you to reach your fat loss goals. In this episode, find out:—Why we are changing the name of our "COVID Update" segment to our "Health Freedom Update" after three years.—What is happening right now with a child care crisis as the country has a "triple-demic" of flu, RSV, and COVID. And the reason why the immune systems in children are compromised right now as a result of the lockdowns and isolation. —The major change in their COVID policy that the Communist regime in China just made after their people rose up in protest. And why Dr. Prather says that the surge of COVID in China proves that "lockdowns don't work, masks don't work, and the vaccines don't work".—How the current COVID vaccine is ineffective against the current COVID variants. And how you are more susceptible to get the latest variants the more shots and boosters that you receive. —The mechanism of the vaccine that triggers an IgG4 response in your immune system that treats the COVID variants as a harmless pollen instead of as a more dangerous virus. And how this same response was previously seen in RSV vaccination campaigns in Africa that made it more likely for someone who was vaccinated to get RSV. —The increased risk of Myocarditis and Pericarditis in young men and athletes who have received the COVID vaccine, which has caused other countries to actually ban the vaccine for young men.—How you can protect yourself and your loved ones by building up your immune system. And the "critical" importance of correct diagnostics to find out the exact state of your health (such as Vitamin D, Zinc, and Iodine levels).—The story of Robert, a patient at Holistic Integration, and how he lost 45 pounds in his first three months on our Fat Loss Program! —Why having a Health Coach to guide and encourage you is so important when you are trying to make positive, long-lasting changes in your health. —How you can get a free consultation with our Health Coach (which includes a Body Composition Analysis and Fit3D Scan) by attending our free Open House Event on Wednesday, January 11th at 6 p.m.http://www.TheVoiceOfHealthRadio.com

In this 155th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we discuss the state of the world through an evolutionary lens. This week, we discuss USDA organic certification, Whole Foods, and why people make inconsistent decisions in their own lives. We talk about new research published in Science Immunology that finds that the degree to which people are mRNA vaccinated against Covid is correlated with a paradoxical immunological response (with regard to IgG4). We discuss new research published in The Lancet, which pretends to be about how women are faring with monkeypox, but is actually largely about men who are pretending to be women; we also review The Lancet's final op-ed of 2022, which bemoans a “breakdown of trust in the state and in scientists.” Finally, we discuss how glass frogs become transparent: by sequestering blood in their livers. ***** Support the sponsors of this show: Thesis: personalized nootropics for motivation, creativity, confidence and more. To get a customized Thesis starter kit, take the quiz at takethesis.com/DARKHORSE, and use code DARKHORSE at checkout for 10% off your first box. Eight Sleep: Personalized thermoregulation while you sleep, and when you wake. Eight Sleep's amazing Pod Pro Cover (for your mattress) is $150 off at www.eightsleep.com/darkhorse Sole: Beautiful shoes and carefully designed footbeds for healthy feet. Go to https://yoursole.com/darkhorse , and first-time customers get 50% off any footbed, plus they have a 90-day money back guarantee. ***** Our book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, and signed copies are available here: https://darvillsbookstore.indielite.org Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com Find more from us on Bret's website (https://bretweinstein.net) or Heather's website (http://heatherheying.com). Become a member of the DarkHorse LiveStreams, and get access to an additional Q&A livestream every month. Join at Heather's Patreon. Like this content? Subscribe to the channel, like this video, follow us on twitter (@BretWeinstein, @HeatherEHeying), and consider helping us out by contributing to either of our Patreons or Bret's Paypal. Looking for clips from #DarkHorseLivestreams? Check out our other channel:  https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIA Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music. ***** Q&A Link: https://youtu.be/8sb6jRZidlA Mentioned in this episode: USDA Organic Certification (two links): https://www.usda.gov/media/blog/2020/10/27/organic-101-allowed-and-prohibited-substanceshttps://www.usda.gov/media/blog/2012/10/10/organic-101-five-steps-organic-certificationIrrgang et al 2022. Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated  SARS-CoV-2 mRNA vaccination. Science Immunology, p.eade2798. https://www.science.org/doi/full/10.1126/sciimmunol.ade2798 IgG4-related disease (IgG4RD) means FIBROSIS and organ destruction (Jessica Rose, 12-28-22): https://jessicar.substack.com/p/igg4-related-disease-igg4rd-means Trainwreck of all trainwrecks (12-24-22): https://www.rintrah.nl/theSupport the show

Recorded on NYE, we bring in 2023 with the latest troubling IgG4 study, a cheeky narrative pivot from your mainstream media and pontificate on why Moderna has signed deals to open mRNA vaccine factories in Australia, Canada and most recently the UK.

It turns out that I was correct with my assumption about the immune system getting shut down. Referencing the federal register, we find out that nothing has changed with the FDA's methods in decades.

Oversiktsepisode. Gjest: Jon Aambakk, konstitutert overlege ved ØNH-avdelingen, Stavanger universitetssjukehus.Prosedyre for IgG4-relatert sykdom (norskrevmatologi.no).Første sesong av podcasten er finansiert av Norsk revmatologisk forening. Hosted on Acast. See acast.com/privacy for more information.

Oversiktsepisode. Gjest: Jon Aambakk, konstitutert overlege ved ØNH-avdelingen, Stavanger universitetssjukehus.Prosedyre for IgG4-relatert sykdom (norskrevmatologi.no).(Første sesong er finansiert av Norsk revmatologisk forening) Hosted on Acast. See acast.com/privacy for more information.

Oversiktsepisode. Gjest: Jon Aambakk, konstituert overlege ved ØNH-avdelingen, Stavanger universitetssjukehus.(Første sesong av podcasten er finansiert av Norsk revmatologisk forening). Hosted on Acast. See acast.com/privacy for more information.

Regular listeners to Raise the Line know so-called "rare diseases" aren't really rare when you consider up to thirty million Americans are affected by them directly. That makes it likely you know someone who is impacted, or you know one of their colleagues, friends or loved ones. That fact has hit home at Osmosis over the last few months as we've started planning a major focus on rare diseases for 2023, which we're calling The Year of the Zebra. Several teammates have come forward to tell us their rare disease stories and we'll be sharing some of those on the podcast in the coming months. First up is our Director of Nursing Education Dr. Maria Pfrommer and her husband, Jack, who join host Shiv Gaglani to offer insights into the diagnosis and treatment journey they've been on to deal with Jack's battle with retroperitoneal fibrosis, an inflammatory condition which can cause obstructions in the urinary tract. While Maria's vast clinical knowledge and experience in healthcare systems has obviously been helpful, it was still a struggle to get the right diagnosis and treatment due to limited experience among healthcare professionals with rare conditions. “From my perspective, I really think that we need to learn more about rare disorders from every level of care,” she says. Tune in for great real-world advice for healthcare professionals dealing with rare disease patients including the importance of listening to the patient, understanding their whole life picture and focusing on transitions of care.

Dr. Hugues Allard-Chamard from the University of Sherbrooke joins Dan to take a fascinating deep dive into the world of IgG4-related disease. Together they tackle the basics, like what IgG4-related disease is, the clinical spectrum of the disease, the phenotypes that we should look for clinically, an approach to diagnosis, the best tissue to biopsy, and what to look for on pathology. They discuss common mimics of the disease, how to treat it, a look at the recently published open label study on use of Abatacept (of which Hugues was an author), how and when to use Prednisone, and what's in the pipeline for IgG4-related disease.Dr. Hugues Allard-Chamard is a Rheumatologist and Assistant Professor at the University of Sherbrooke where his research focuses on immunology and IgG4-related disease.Dr. Daniel Ennis is a Rheumatologist and Vasculitis Specialist at the University of British Columbia.Co-host Dr Janet Pope is off for this episode and back again with us next time.Around The Rheum (ATR) is produced by the CRA Communications Committee. A special thank you to the podcast team, Dr. Dax G. Rumsey (CRA Communications Committee Chair), Dr. Daniel Ennis (Host), and David McGuffin (Producer, Explore Podcast Productions) for leading production.Our theme music is by Aaron Fontwell.You can claim podcasts as a scanning activity under the Section 2 MOC Program for 0.5 credits per podcast. For more on the work of the Canadian Rheumatology Association (CRA), please visit www.rheum.ca.

Scientists found that successive doses of the mRNA vaccines start to habituate or desensitize the subjects to the COVID-19 proteins, migrating their immune response over to being dominated by the IgG4 form, which essentially teaches the body to tolerate the proteins. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Let's get started!    Simon: Hi Dr Cabral, I am looking to improve my immune defenses against a 'certain virus' and am concerned that my white blood cell count is sub-optimal (4,000/ul) despite my otherwise good health. I suspect this may be a hangover from having VERY low WBC levels after contracting dengue fever 5 years ago. Is increasing my WBC something I should be exploring and what can I do to get my count up?   Lorena: Thank you so much for all you do for your community! Not sure if you remember but I asked here a few weeks ago regarding my elevated heart rate at night according to my Oura ring and that I started to experience a lot of neurological symptoms (similar to MCAS) such as anxiety, heart palpitations and pseudoseizures at the same time. You mentioned that I should check my cortisol levels at night (which I did and was slightly elevated in the PM and low in the AM). I'm a Vata level 1 and 2 IHP so I literally ran all of the labs that you can imagine as I was very confused as to what was going on. Hormones, heavy metals, stool, OAT, neurotransmitters + more. Everything was fine except some candida/mould overgrowth as well as elevated toxic metals. I started the CBO again (last one was over a year ago) + heavy metal detox + 21 day detox all at the same time lol. Anyways, I haven't felt any neurological symptoms after just a couple of days of starting these protocols. I can't figure out how this would have happened. Surely 2 days worth of protocols is not enough to stop these symptoms (very happy though). Any idea why?   Lorena: Hi Doc, me again! I forgot to mention that I also ran a precision allergy test by Precision Point Diagnostics because they test IgE, IgG, IgG4 and complement (C3d) from blood serum. It's much more expensive so not very affordable for a lot of people. Anyways, a lot of things came up and I also eliminated the ones in the red section of my IgE and IgG (vanilla, banana & more) at the same time that I started all the protocols. A lot of them showed in the IgE section and these were foods that I was consuming on a daily basis when I was having all of those symptoms. Do you think it might have been the removal of these foods that caused the relief of symptoms so quickly? If so, it's crazy how consuming foods you're sensitive to from an IgE and IgG perspective can do to you! I always thought this wasn't a big deal but it clearly is.    Nina: Hi doctor Cabral, I get very lightheaded every time I bend down to pick up something. Do you know why this is happening? I do have a low blood pressure, so maybe that could have something to do with it, but I really want to know if there's anything else that could be causing it. I also always feel cold, especially in my extremities. Just to give you some background, I'm a 44 year old female, no kids, vegan and pretty active. Thanks so much for your answer, I really appreciate your help! Nina   Farrel: Hello, Dr Cabral. I trust you and your family are in great health. Listening to older episodes and about two years ago on a House call segment you were asked about Tongkat Ali and it's use for athletes and men in their 30's. You went on to say there's a product your team will be launching around September 2020 called Libido Booster. I purchase from the site and I've never seen it. Has the launch been put on hold or it won't be released? Keep up great work.   Andjela: Hello Dr!! Thanks for your information! Love following you on Instagram. I had covid (delta) in October 2021, and now 3 months later experiencing hair loss. So are many of my relatives who all had it at the same time. Any suggestions on remedies?   Danielle: Hello Dr. Cabral,Thank you so much for sharing your knowledge in functional medicine. I've read your book twice and have no doubt I'll read it again. I listen to this podcast daily and am awaiting the arrival of the minerals and metals test. My question is related to IIH. (I understand the medical advice disclaimer) Are there any natural ways to reduce pressure in the head? I do not want a LP. How else can I reduce excess fluid? I do take L-Lysine and well as a long list of other supplements daily. I'm also taking Goduchi and Triphala as herbal support and am on 2 pharmaceuticals as well, which Id love to come off of, safely, of course. Thanks so much for your time. Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/2214 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -  Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)

Phillip Moreau, MD, PhD, Head of the Hematology Department at the University Hospital Phillip Moreau, MD, PhD, Head of the Hematology Department at the University Hospital Hôtel-Dieu, discusses the updated results from MajesTEC-1, a phase 1/2 study of teclistamab in relapsed/refractory multiple myeloma. These results were recently presented at The American Society of Hematology Meeting & Exposition (ASH 2021).Multiple myeloma is a rare blood cancer. While the disease is treatable, relapses are common and some patients are refractory to first line treatment.As Dr. Moreau explains, MajesTEC-1 is a phase 1/2 study testing teclistamab in relapsed/refractory multiple myeloma. Teclistamab is a T-cell redirecting, bispecific IgG4 antibody that targets both B-cell maturation antigen (BCMA) and CD3 receptors to induce T-cell mediated cytotoxicity of BCMA-expressing myeloma cells. In this study, two cohorts were evaluated, one cohort given teclistamab weekly and one biweekly. Updated data on both of these cohorts was presented at the ASH 2021 meeting. Response rates from both cohorts were encouraging with up to 75% of patients responding to treatment with teclistamab. As of the clinical cutoff, no new safety signals were identified in the phase 2 study. The most common nonhematologic AEs in all 159 patients treated at the recommended phase 2 dose were cytokine release syndrome, injection site erythema, and fatigue. The most common hematologic AEs were neutropenia, anemia, and thrombocytopenia.According to Dr. Moreau, the take home message from this data is that teclistamab is a novel, tolerable, off-the-shelf agent that is immediately available. As a result, the use of teclistamab for advanced patients with BCMA may be approved fairly soon. Longer follow-up of multiple myeloma patients receiving teclistamab is necessary.

「IgG4関連疾患」（解説）関西医科大学香里病院 病院長　　岡崎和一氏（ききて）順天堂大学教授　　池田志斈氏

This episode briefly covers the various causes of benign biliary strictures. This includes:Iatrogenic causes- Bile duct injuries at cholecystectomy- Trauma, post-liver transplant, and hepaticojejunostomyGallstone related- Mirrizi syndromeInflammatory causes- Primary Sclerosing Cholangitis- Parasitic infections including liver flukes, echinococcus and roundworm- HIV/AIDS-associated cholangiopathy- IgG4 related cholangiopathyCongenital- Biliary atresia- Choledochal cystsDisclaimerThe information in this podcast is intended as a revision aid for the purposes of the General Surgery Fellowship Exam.This information is not to be considered to include any recommendations or medical advice by the author or publisher or any other person. The listener should conduct and rely upon their own independent analysis of the information in this document.The author provides no guarantees or assurances in relation to any connection between the content of this podcast and the general surgical fellowship exam.  No responsibility or liability is accepted by the author in relation to the performance of any person in the exam.  This podcast is not a substitute for candidates undertaking their own preparations for the exam.To the maximum extent permitted by law, no responsibility or liability is accepted by the author or publisher or any other person as to the adequacy, accuracy, correctness, completeness or reasonableness of this information, including any statements or information provided by third parties and reproduced or referred to in this document. To the maximum extent permitted by law, no responsibility for any errors in or omissions from this document, whether arising out of negligence or otherwise, is accepted.The information contained in this podcast has not been independently verified.© Amanda Nikolic 2021

Have the Architects of the Covid-19 Pandemic Lost Touch with Reality?   Richard Gale & Gary Null PhD Progressive Radio Network, May 28, 2021   As the pandemic wages into its second year, two diametrically opposing movements have consolidated in defiance against each other. The dominant contingent, represented by Biden, Congress, Anthony Fauci, Bill Gates and the mainstream media, has decided that any citizen who refuses a Covid-19 vaccine is a de facto enemy of the state. “Ultimately,” Joe Biden declared during another gaff remark about the status of the government’s vaccination campaign, “those who are not vaccinated will pay – end up paying the price.” Despite the dubious claims that the mRNA vaccines are approximately 95 percent effective, the unvaccinated therefore mysteriously pose a health risk to the vaccinated. Consequently, any punitive actions the federal and state governments undertake, including encouraging the social media to publicly shame and censor voices of caution and reason, are justified.    In an effort to marginalize and socially victimize Israeli citizens who have postponed or refused vaccination, Netanyahu and his right-wing Knesset supporters passed a bill permitting personal information and data about unvaccinated citizens to be shared across government agencies and civil institutions.  Israel was named by Pfizer’s CEO Albert Bourla as the “world’s lab” for the company’s Covid-19 vaccine roll out. Contrary to the government’s response to criticisms, the unvaccinated are theoretically second-class citizens, branded with a “scarlet letter” depriving them of full engagement with Israeli society, including going to a restaurant, attending a movie, concert or athletic event. Many are unable to shop or go to work.  Even the staunch pro-Zionist New York Times indicated the government’s policies are “moving in the direction of a two-tier system for the vaccinated and unvaccinated.”    An analysis comparing Israeli Covid-19 infection and vaccine-related deaths conducted by Dr. Herve Seligmann, an Israeli-national at Aix-Marseille University of Medicine’s Faculty of Emerging Infectious and Tropical Diseases, concluded that the Pfizer vaccine has caused “mortality hundreds of times greater in young people compare[d] to the mortality from coronavirus without the vaccine, and dozens of times more in the elderly, when the documented mortality from coronavirus is in the vicinity of the vaccine, thus adding greater mortality from heart attack, stroke, etc.”  Seligmann and his co-author Haim Yativ have referred to Netanyahu’s draconian policies with unsafe experimental vaccines as a “new Holocaust.”  A civilian organization, the Israeli People Committee, which includes many health professionals, released a devastating report on the number of injuries and deaths resulting from Pfizer’s vaccine.  It was during the peak of the government’s vaccination campaign that Israel experienced its highest mortality rate, especially among those between 20 and 29 years of age. The Committee reported, “26 percent of all cardiac events occurred in young people up to the age of 40, with the most common diagnosis in these cases being myositis and pericarditis.” Other adverse vaccine reactions included infarction, stroke, miscarriage, impaired blood circulation and pulmonary embolisms.   Nevertheless, Israel has become the poster child for far more than serving as Pfizer’s experimental laboratory for human ferrets. It also models a caste society of haves and have nots, the rewarded and the repressed, the vaccine-anointed and the untouchables, as strategized by the World Economic Forum’s future technological proposals in its Great Reset. Netanyahu is has seemingly fully bought into Schwab’s Fourth Industrial Revolution and it’s re-visioning of the very definition of the human species. Last October, during the WEF’s “Great Reset” virtual session, Netanyahu appeared with Colombia’s far-right president Ivan Dugue – polled as the least popular president during that nation’s history -- and Rwanda’s war criminal Paul Kagame, along with executives in the biotech and financial industries, to advocate on behalf of the Forum’s mantra that the pandemic is an “opportunity” to further mobilize global digital infrastructure systems, including Covid-19 vaccination verification via microchip technology.   Now we are witnessing Canada, the UK and the US aggressively mimicking Israel’s heavy-handed policies to establish full-spectrum social control and make efforts to implement a post-modern, technologically driven caste system. Although Biden stated he does not support a federal mandate on vaccination passports, it has been left to the individual states to decide. Democrat-controlled states, notably New York, are issuing vaccine passports as a ticket to allow the vaccinated to return to a new normal. Republican governors on the other hand have been quick to denounce them, and in the case of Arizona, Florida, Idaho, Montana and Texas to executively ban them altogether. Hopefully some of the bans will challenge many of the over one hundred private colleges and universities that decided to require students to be vaccinated before returning in Fall.   The mainstream corporate-Democrat media, led by the New York Times, Washington Post, the Daily Beast, US News & World Report, CNN, NPR and MSNBC spew volleys of baseless propaganda that the vaccines are effective and wholly safe. However, thousands of medical school professors, physicians and researchers worldwide are challenging this non-consensual assumption. They regularly point out that there is no reliable science to justify any such claims. This raises the question: what are the vaccines effective against? Surely not contracting SARS-CoV-2; thousands of fully-vaccinated people are testing positive with the infection. The CDC has reported “seven percent of those [vaccinated] who have been infected have been hospitalized and 74 have died.”   Government efforts to reach a fictitious herd immunity threshold will inevitably come at a great cost to human life. More recent studies suggest that an exceedingly large percentage of Americans should technically be exempt from Covid-19 vaccines.  The University of Michigan published a recent analysis in JAMA Network Open suggesting that three percent of vaccinated Americans taking immune-weakening drugs have an increased risk of hospitalization. The study is grossly conservative and undermines the breadth of the problem. The researchers only analyzed patients with private insurance, under the age of 65, and who were only prescribed immunosuppressive steroids, such as corticosteroids and prednisone. Other immunosuppressive drugs such “selective immunosuppressants” and calcineurin and interleukin inhibitors were seemingly excluded from the Michigan analysis. Thirty-three percent of the American population was therefore excluded from the study because, according to the CDC, only 66.8 percent of the population has private health insurance. New York University researchers reported in the British Medical Journal that a third of patients receiving methotrexate and TNF-inhibitors for immune-mediated inflammatory illnesses such as rheumatoid arthritis and psoriasis fail to achieve sufficient antibodies from the Pfizer vaccine. We are certain this will be found equally true for many other medications if or when studies are conducted.    The CDC’s belief that only 4 percent of Americans are immune-compromised is a misleading under-estimation. The agency’s defining criteria is narrow and limited to HIV/AIDS and cancer patients, inherited genetic diseases, and patients who have undergone organ transplants and are prescribed immunosuppressive drugs. On the other hand, there are over 100 different autoimmune conditions, including type-1 diabetes, multiple sclerosis, blood cancers, lupus, fibromyalgia, rheumatoid and other types of arthritis, psoriasis, IgG4 disease, Hashimoto’s and Addison’s diseases, celiac disease, etc. These additional individuals, who account for over 50 million Americans, have malfunctioning immune systems that increase their susceptibility to both severe SARS-CoV-2 infections (if left untreated during its early stage) and a higher probability of vaccine adverse reactions.    Consequently, a very conservative 17 percent of Americans are at greater risk from either viral infection or vaccine injury or death. This also excludes tens of millions of adults (30 percent) and children (40 percent) with chronic allergies and many of the over 89,000 cancer patients diagnosed annually and prescribed chemotherapeutic drugs. Every year, nearly two-thirds of all Americans require emergency medical care from allergic reactions alone.  Furthermore, those with certain immune weaknesses are less likely to generate sufficient vaccine-induced antibodies thereby making Covid-19 vaccination ineffective.    Especially disturbing is that the clinical trials the FDA relied upon for Emergency Use Authorization for the past five months of the vaccination campaign were based upon enrollment of healthy participants. Only recently are clinical trials either underway or in recruitment to test the vaccines on participants with weakened immune systems, including small children and infants, and on pregnant women. In the meantime, millions of immunosuppressed people diagnosed with autoimmune conditions or pre-existing comorbidities, from young to old, are being indiscriminately injected. Given the CDC’s previous track record of reckless vaccination policies, upon these trials’ completion, we will surely see vaccination forced upon every infant carelessly. This has been a policy enacted so far on the elderly, the sickly, the immune-compromised, pregnant moms, and the rest of the nation. It is not irrational, therefore, to suspect that past and present Covid-19 trials have been conducted with malice of forethought and with the unconditional approval of our federal health officials.    During the pandemic, the rapid ascent of our vaccine-addicted culture’s mantra of “vaccination at any cost” truly borders on medical malfeasance and criminal negligence. The overriding emphasis on vaccination and near total disregard for implementing very simple preventative measures to inhibit infections from progressing in severity. If our health policymakers were wise men and women, alternative treatments such as ivermectin, hydroxycholoroquine, and more recent inexpensive off-patent drugs, which have been shown to be highly effective for early stage treatment and being widely prescribed elsewhere in the world, would be permitted and encouraged without reservation. There would be no reason to wait for a novel drug costing thousands of dollars per patient to arrive.  And we still await that magic bullet drug because the previous one, remdesivir, was faulty blank. This is just another example of the institutionalized pathology that infects our health agencies.    There is no convincing science to support our federal officials belief that a previously infected person requires a Covid-19 vaccine to acquire immunity. In fact, more recent research indicates the opposite and goes directly against the intellectually fetid arguments of the now disgraced financier Bill Gates that every person on the planet should be vaccinated without exception. Johns Hopkins University professor Dr. Marty Makary has put forth the evidence that “natural immunity works.” Makary notes that it is only the rare instance when a person is being re-infected. Washington University School of Medicine reported this month that even mild Covid-19 infections induce long lasting antibody protection. The study’s lead researcher Dr. Ali Ellebedy stated,   "Last fall, there were reports that antibodies wane quickly after infection with the virus that causes COVID-19, and mainstream media interpreted that to mean that immunity was not long-lived… But that's a misinterpretation of the data. It's normal for antibody levels to go down after acute infection, but they don't go down to zero; they plateau. Here, we found antibody-producing cells in people 11 months after first symptoms. These cells will live and produce antibodies for the rest of people's lives. That's strong evidence for long-lasting immunity."   The information we were fed to downplay natural immunity was wrong at best, and more likely a lie, in order to further persuade the public into the importance of the vaccines to return their lives to normal. Another study appearing in this month’s Journal of Infectious Diseases found that “SARS-CoV-2 specific immune memory response [following infection] persists in most patients nearly one year after infection.” The Covid-19 vaccines can’t make the same promise. In fact, more reports show that  fully vaccinated persons are becoming infected.    But it gets worse.     The pro-vaccine argument wrongly assumes that anyone who refuses the Covid-19 vaccines is therefore anti-vaxxer. We would argue it is rational caution in the face of a national healthcare system indebted to the pharmaceutical industry and that is rapidly losing public trust. Likewise, if a doctor is successfully treating hundreds of patients without a reported death with cheap, effective drugs, she or he is canceled and ridiculed as a quack. Instead of open dialogue and debate, those who challenge the Medical Church Scientific are censored by Google and from all social platforms, such as Facebook, Twitter and Wikipedia. This is despite the impeccable credentials of many medical professionals abiding by the precautionary principle and who dare to challenge Anthony Fauci and the global vaccine czar Bill Gates, whose faux philanthropy is nothing less than another profitmaking enterprise like Microsoft.    Conflicts of interests, both financial and non-financial, are endemic in our medical system. Therefore it becomes increasingly more difficult to trust any clinical study or government policy that is based upon flawed evidence submitted by a drug maker that fails to undergo a thorough independent and impartial review by qualified medical experts. There is a clear psychological reason for this. Many psychologists have pointed out over the years that “cognitive bias,” “motivated reasoning” and the heuristics driving the evaluation of clinical trial data and the subsequent institutional regulatory review and decision-making are deeply contrary and undermine the entire evidence-based criteria that should oversee what drugs, vaccines, medical devices, therapeutic protocols should be recommended or approved for use upon the public.     The late Scott Lilienfeld, a professor of psychology at Emory University, writes, “Clinicians are subject to the same errors in thinking that affect virtually all people. In particular, practitioners must be wary of (a) the misuse of certain heuristics (e.g., availability, representativeness) and (b) cognitive biases (e.g., confirmation bias, hindsight bias) in their everyday work.” Although Lilienfeld is singling out clinical physicians, it applies more rigorously and accurately to the pharmaceutical presidents, CEOs and chief science officers overseeing vaccine development who have stock prices to reach and shareholders to please.  Cognitive bias equally plagues the entire executive hierarchy at the CDC, NIAID, FDA and HHS who are beholden to the gaping revolving door between these agencies and private industry and their revenues. Writing about the deep ethical concerns behind bias in our medical institutions, Dr. Thomas Murray, President of the Hastings Center, states, “For scientists on a panel of the Food and Drug Administration, for example, it isn’t immediately clear to whom they owe their primary loyalty.”  Such biases, Murray believes, have completely destroyed the credibility of the World Health Organization.     The fact that rates to reproduce medical clinical trials are so poor, according to behavioral economist Susann Fielder at the Max Planck Institute, is that “cognitive biases may be a reason for that.”  It also explains why Stanford University Medical School professor John Ioannidis argues, “most published research findings are false,” and “an estimated 85 percent of research resources are wasted.” Junk science based upon bias should also include every vaccine application submitted to the FDA for regulatory approval, since the vaccine companies are privileged to cherry-pick whichever trials they want to submit to create the most promising portfolio.    One could review all of the official decisions made during the past 17 months – by Anthony Fauci, Trump and Biden and the naïve stances in both political parties – and should easily observe the frailties of cognitive bias and repeated contradictions throughout. None whatsoever are reliably truthful. And of course, cognitive bias leads to cognitive dissonance, such as denying that one has a bias or resorting to flagrant rejection and disparagement in order to avoid any scientific data that conflicts with one’s unfounded beliefs.   We now live in a nation of medicine by bureaucratic decree rather than by immunological science. This is postmodern cultism at its worst because it hides behind the veneer of being scientific. And it has the full support of a political technocracy that can ordain authoritarian laws. There is a dire need for a collective epiphany. All of us are experiencing the pandemic as a failed experiment orchestrated by institutions that have lost touch with reality. And it has been a very deadly experiment due to the extraordinary incompetence of our medical-degreed bureaucrats. Sadly the decades of institutional ineptitude has had to reach national and perhaps global awareness at this time when the powers that possess every technological tool at their disposal to conduct wide surveillance, pass undemocratic and draconian laws with full impunity, and control the fenced sheep within the mainstream media. Attachments area

For today's episode we will be reviewing three articles from the Sept-Oct 2020 issue of Allergy Watch, a bimonthly publication which provides research summaries to College members from the major journals in allergy and immunology. You can also earn CME credit by listening to this podcast! For information about CME credit or to read archived issues of Allergy Watch, head over to https://college.acaai.org/publications/allergywatch Please watch out for continued discussion on this topic in the ACAAI Community on DocMatter, we'll have key talk takeaways with the opportunity for ongoing conversation about today's topic! Article links: Changes in asthma severity in the first year of school and difficulty learning to read. IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.   Sialylation of immunoglobulin E is a determinant of allergic pathogenicity.   Please rate our podcast on iTunes! Please give us feedback, corrections, and suggestions! Email feedback to: allergytalk@acaai.org ACAAI is presenting this podcast for educational purposes only. It is not medical advice or intended to replace the judgment of a licensed physician. The College is not responsible for any claims related to procedures, professionals, products or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services or methods that might be referenced. Today's speakers have the following disclosures: Drs. Lee and Kalangara has nothing to disclose Dr. Fineman Speaker: AstraZenca, Boehringer Ingelheim, Shire; Research: Aimmune, DBV, Shire, Regeneron.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Our immune system provides the means for us to live in a world full of pathogens. However, sometimes it gets it wrong and we can find ourselves debilitated because of our own immune system. Allergies and hypersensitivies fall into this category, with symptoms ranging from the mildly irritating, to the life-threatening anaphylaxis. Our knowledge of these ailments come from a variety of observational and experimental studies. In the late 1800's and early 1900's, they did not understand the immune system nor allergies. Terms used to describe these diseases (that we know today as allergies) were Summer colds, Summer flu, Hay-asthma, and Hay-fever. The causes were unknown, the treatment ranged from experimental to dangerous and the Scientists often used themselves as the study subjects/volunteers. However, it took some clever minds and quite a bit of courage (not to mention a lot of dogs and other experimental animals) to gather the understanding of these conditions that we have today. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP's Immunology Department is the largest laboratory of its kind in Australia.See omnystudio.com/listener for privacy information.

Our immune system provides the means for us to live in a world full of pathogens. However, sometimes it gets it wrong and we can find ourselves debilitated because of our own immune system. Allergies and hypersensitivies fall into this category, with symptoms ranging from the mildly irritating, to the life-threatening anaphylaxis. Our knowledge of these ailments come from a variety of observational and experimental studies. In the late 1800's and early 1900's, they did not understand the immune system nor allergies. Terms used to describe these diseases (that we know today as allergies) were Summer colds, Summer flu, Hay-asthma, and Hay-fever. The causes were unknown, the treatment ranged from experimental to dangerous and the Scientists often used themselves as the study subjects/volunteers. However, it took some clever minds and quite a bit of courage (not to mention a lot of dogs and other experimental animals) to gather the understanding of these conditions that we have today. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP's Immunology Department is the largest laboratory of its kind in Australia. See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** COVID-19: Testing the strength of nations As the pandemic continues to rage, we take a snapshot in time about our current understanding from an epidemiological, pathological, microbiological and immunological viewpoint of COVID-19. This pandemic has tested the Governments, Politicians and the Public Health of nations; some have responded valiantly; others have been found lacking. The deviation from our regular style podcast is because we are living the COVID story. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP's Immunology Department is the largest laboratory of its kind in Australia. Known for pushing the boundaries and pioneering new technologies it is acknowledged as the most advanced flow cytometry lab in diagnostic practice. With Australia's most diverse range of autoantibody assays, the lab is also at the forefront of autoantibody testing. In a partnership with a UQ engineering research team it is breaking new ground in digital pathology and image analysis. See omnystudio.com/listener for privacy information.

COVID-19: Testing the strength of nations As the pandemic continues to rage, we take a snapshot in time about our current understanding from an epidemiological, pathological, microbiological and immunological viewpoint of COVID-19. This pandemic has tested the Governments, Politicians and the Public Health of nations; some have responded valiantly; others have been found lacking. The deviation from our regular style podcast is because we are living the COVID story. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP's Immunology Department is the largest laboratory of its kind in Australia. Known for pushing the boundaries and pioneering new technologies it is acknowledged as the most advanced flow cytometry lab in diagnostic practice. With Australia's most diverse range of autoantibody assays, the lab is also at the forefront of autoantibody testing. In a partnership with a UQ engineering research team it is breaking new ground in digital pathology and image analysis.  See omnystudio.com/listener for privacy information.

What you need to know for your boards: Epidemiology, mechanisms, presentation, work-up, management, prognosis and of course, quiz time! Special thanks to Dr. John Stone for his ongoing help with my IgG4-related questions over the years.

Aquí conversando con Alfonsina Pérez de @ortho_fit_dr quién nos cuenta su historia que inició con una caída y que hoy en día tenemos un diagnóstico de "Enfermedad por depósito de Igg4" y rumbo a la 4ta prótesis. . . #resiliencia #fortaleza #valentía #coraje #aceptación #aprendizaje #autoinmune #historiasdeguerra #artritis #enfermedadcronica #emfermedadpordepositodeigg4

Pillai explains IgG4-Related Disease (IgG4-RD), a chronic inflammatory condition characterized by elevated numbers of T cells and IgG4 secreting plasma cells in the affected tissue. Using tissue samples from patients with the disease, his laboratory isolated and characterized the CD4+ T cells associated with IgG4-RD. Furthermore, he explains how the crosstalk between these CD4+ T cells and B cells is important for IgG4-RD development, and showed that depletion of B cells improves the outcome of the disease.  

Dr. Akrithi Udupa (fellow at Duke) and Dr. Allen Witt (resident at Duke) join the podcast to discuss IgG4-RD and the new classification criteria published by Wallace et al in Arthritis & Rheumatology in January 2020.Reference: Wallace et al. The 2019 American College of Rheumatology / European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis & Rheumatology. 2020;72(1):7-19.Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

What you need to know for your boards: The epidemiology, presentation, and a particular focus on diagnosis, work-up and management of osteoporosis.

(Cápsula 025) La enfermedad relacionada a IgG4 puede causar lesiones fibro-inflamatorias en casi cualquier órgano. Se requiere una correlación entre las manifestaciones clínicas, radiológicas y de histopatología para un diagnóstico adecuado. Esta fue diferenciada como una entidad en el 2003 y, aunque puede afectar cualquier órgano, tiene predilección importante por ciertos sistemas. Estos incluyen las glándulas salivares mayores, órbitas, glándulas lacrimales, páncreas y árbol biliar, pulmones, riñones, aorta y retroperitoneo, meninges y glándula tiroidea.ENLACE: https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.41120

  Struggling with puffy eyes, swelling of the hands, weight gain, chronic sinus issues or stomach pain? Chances are you are experiencing inflammation caused by food sensitivities. Perhaps you’ve tried to eliminate certain foods but haven’t seen results. Stop guessing what foods you are sensitive to and consider testing to pin point your sensitivities. In this episode Dr. Jannine Krause interviews Dr. Chris Meletis on why food sensitivity testing is valuable to reduce total body inflammation. Why rapid aging is connected to food sensitivities Why testing helps you distinguish earned vs true sensitivities What is tested when looking at food sensitivities What IgE, IgG, IgG4 and IgA testing results mean

Dr. David Lapides discusses a Neurology: Neuroimmunology & Neuroinflammation review of IGG4 hypertrophic pachymeningitis from the July 2019 issue. 

John Stone, MD, MPH, is the world leader in the field of IgG4-related disease research. In this episode, he breaks down the histology of IgG4-related disease, important aspects of what is known about the pathophysiology of the disease, as well as future directions in treatment. Intro :10 Inside this episode :13 IgG4-related disease background :31 An anecdote 1:15 The interview 4:09 History of IgG4-related disease 4:18 IgG4 pathology and terms 7:48 What makes IgG4 different from other IgG subclasses? 10:23 What do we know about the interplay between B and T cells? 12:31 What is SLAMF7? 16:30 What happens to T cells during B-cell depletion? 18:22 Antigens involved in IgG4 21:06 Future of treatment 23:10 Thank you, Dr. Stone 24:32 We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum John Stone, MD, MPH, is director of clinical rheumatology at Massachusetts General Hospital.

Jeffrey S. Klein, MD, Editor of RadioGraphics, discusses 6 articles from the Novebmer-December 2018 issue of RadioGraphics. ARTICLES DISCUSSED: Breast Cancer Tissue Markers,Genomic Profiling, and Other Prognostic Factors: A Primer for Radiologists., RadioGraphics 2018; 38:1902–1920; 2017 AUA Renal Mass and Localized Renal cancer guidelines:Imaging Implications., RadioGraphics 2018; 38:2021–2033; HIV-related Malignancies and Mimics: Imaging Findings and Management., RadioGraphics 2018; 38:2051–2068; IgG4-related Cardiovascular Disease from the aorta to the Coronary arteries: Multidetector CT and PeT/CT., RadioGraphics 2018; 38:1934–1948; Primary Lung Tumors in children:Radiologic-Pathologic correlation., RadioGraphics 2018; 38:2151–2172; Role of FDG PET/CT in the eighth edition of TnM Staging of non–Small cell Lung cancer., RadioGraphics 2018; 38:2134–2149.

Host: Madelaine A. Feldman, MD, FACR Dr. Marissa Sansone from Jersey City Medical Center-Barnabas Health shares her case study addressing IgG4-related diseases, such as fibroinflammatory disorders, with Dr. Maddie Feldman at this year’s Congress of Clinical Rheumatology’s Annual Meeting.

In this episode Dr. Daniel Ennis leads us through an old case with new symptoms. With the help of Dr. Barry Kassen, the group explores the approach to an individual whose organs seem to keep "exploding". How do you deal with diagnostic uncertainty? What is your threshold to treat?Is there anything IgG4 can't do? When in doubt, start from the beginning. 

In Folge #128 Mein heutiger Gast ist Nadja Polzin. Nadja Polzin ist ganzheitliche Ernährungsberaterin, Heilpraktikerin i.A., Autorin, Referentin und Bloggerin. Nadja Polzin litt selbst unter verschiedenen Allergien und Unverträglichkeiten. Die fehlenden Antworten der Ärzte, die sie aufsuchte, motivierten sie, die Problematik der Allergien und Unverträglichkeiten auf eigene Faust zu studieren, zu experimentieren, Seminare zu besuchen und sich mit Gleichgesinnten auszutauschen. Das Ergebnis von mehr als fünf Jahren persönlicher Forschung zu diesem Thema und der Erfahrung mit ihren Klienten findet sich in ihrem neuen Buch allergiefrei! Ich kenne Nadja jetzt schon ein paar Jahre und und schätze sie sehr. Ich freue mich sehr, dass ich euch heute dieses geniale Interview mit Nadja präsentieren darf. Bitte beachten Sie auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf https://paleolowcarb.de/haftungsausschluss/ 20% auf alle Produkte im BRAINEFFECT Shop Gutscheincode: Evolutionradioshow - 20% auf alle Produkte im BRAINEFFECT Shop unter www.brain-effect.com Das Video der aktuellen Folge direkt auf Youtube öffnen Und nicht vergessen: Wenn du uns auf Youtube siehst, und wenn du es noch nicht getan hast, dann abonniere unseren Kanal „Evolution Radio Show“ Wenn du das Podcast hörst, dann findest du die Links für Apple iTunes und Android hier auf unserer Homepage Transkript Julia: Ja liebe Nadja, Herzlich Willkommen zur Evolution Radio Show! Nadja: Hallo Julia, freut mich dabei zu sein! Danke für die Einladung. Julia: Ja sehr gerne. Ja wir wollen gleich sozusagen in medias res gehen, gleich anfangen mit dem spannenden Thema, nämlich über Allergien und Unverträglichkeiten zu sprechen. Aber bevor wir so richtig mit dem eigentlichen Thema beginnen: Das Thema Allergien, Unverträglichkeiten beschäftigt dich ja persönlich einfach schon sehr sehr lange. Du schreibst in deinem Buch, dass du schon mit Ende 20 eigentlich, also dass du eigentlich von vorne von Kindheitsbeinen an mit Allergien zu kämpfen hast und Unverträglichkeiten, aber dann so mit Ende 20 sich noch etwas mehr verschlechtert hat, was dich dann auch dazu bewogen hat, weiter zu forschen, dem nachzugehen. Wie war das bei dir, also was hat sich da verändert und was hat dich zum Nachdenken da gebracht und irgendwie auch den Status Quo zu hinterfragen? Nadjas Geschichte, 01:16 Nadja: Ja, das ist eine gute Frage. Also ich habe tatsächlich schon mein ganzes Leben mit Allergien zu tun. Bei mir in der Familie war das durchaus ein Thema. Mein Vater hatte Heuschnupfen. Mein großer Bruder hat Heuschnupfen, und ich bin mit ja so 11, 12 Jahren als Hausstauballergikerin diagnostiziert worden und hatte auch also Atemprobleme, alles was damit zusammenhängt. Mir fingen dann zu Hause an irgendwie den Wellensittich abzuschaffen, den Teppichboden rauszuwerfen, genau. Ja, Tiere waren nicht mehr. Ich bin auch bis heute kein wahnsinniger Tierfreund. Und das waren so die ersten Schritte in das Allergikerleben sozusagen. Und mit Ende 20 kam dann tatsächlich noch ne ganze Menge dazu. Ich habe zu dem Zeitpunkt in Irland gelebt in einem Haus relativ am Ende der Welt sozusagen, am A…., am Ende – genau! Also ich hatte in dem Haus immer Probleme und Schwierigkeiten eigentlich und habe immer irgendwelchen allergischen Reaktionen gehabt, was auch daran liegt, dass es da sehr feucht ist, dass man mit Schimmel zu tun hat usw. Das ist über einen Zeitraum von 2,5 – 3 Jahren dann richtig schlimm geworden, dass ich auch Hautausschläge bekommen habe, dass ich wirklich richtig aufgequollen war. Also das ist mir eine Zeit lang gar nicht so richtig aufgefallen. Das sieht man dann immer erst – wenn ich heute die Bilder sehe, denke ich um Gottes Willen! Also das Gesicht voller Wassereinlagerungen und man ist halt aufgequollen. Ich war auch ein bisschen übergewichtig. Insofern hat sich das auch ein bisschen versteckt. Ja und so bin ich dann zu diesem Thema gekommen und der Ausschlag gebende Punkt war 2012 als ich nach Deutschland zurück gekommen bin und gesagt habe, ok, das geht so nicht weiter - Hautausschläge, viele Depressionen gehabt, Akne gehabt mit Ende 20 noch und jede Menge Beschwerden eigentlich. Also das was man alles mit Ende 20 nicht haben sollte - Gelenkschmerzen, Depressionen, Stimmungsschwankungen, starke Regelblutung und Schmerzen auch in der Zeit, was viele Frauen ja haben und als normal ansehen, was es aber eigentlich nicht ist. Ich habe dann gesagt, ok du änderst jetzt irgendwas. Als erstes nimmst du 15 kg ab, das war so der Ausschlag gebende Punkt. Und so bin ich dann nach und nach in dieses Thema Ernährung auch rein gekommen, über den Sport natürlich und habe mich dann damit beschäftigt. Naja, ok, du probierst jetzt das Eine oder Andere mal aus und stellte fest, es verändert sich irre was, wenn man anders isst. Das war eigentlich der Punkt, wo ich gesagt habe, ok also das lohnt sich jetzt da weiter reinzugucken. Was kann ich damit eigentlich machen? Also konkret habe ich dann irgendwann angefangen glutenfrei zu essen und das hat eine Woche gedauert, bis meine mentalen Beschwerden sich quasi fast in Luft auflösten. Und alles was man so an Stimmungsschwankungen und so was hatte, das war also fast wie weggeblasen. Das war so krass diese Erfahrung, die ich da gemacht habe, so wow – wo ist denn das jetzt hin? Also, mir konnte ja keiner sagen woran es liegt. Meine Hormonspiegel waren in Ordnung und es waren keine auffälligen Blutwerte, ok die eines Allergikers. Immer so ein bisschen erhöhten IGE, aber sonst eigentlich nichts wahnsinnig Auffälliges. Ja, das änderte sich halt wie gesagt innerhalb kürzester Zeit nachdem ich glutenfrei probiert habe, also glutenfreie Ernährung probiert habe. Ok, das hat mich dann nicht mehr losgelassen. Die letzten 5 Jahre waren ein Ernährungsbuch nach dem anderen, um genau zu sein. Julia: Das heißt eigentlich, praktisch war zuerst eigentlich mehr der Wunsch wegen dem Abnehmen. Aber war jetzt gar nicht der Kontext da, aha, ich könnte an den Allergien und an diesen Sachen etwas ändern und es hat sich dann praktisch so als unerwartetes Nebenprodukt auf einmal ergeben, oder? Nadja: Das war es total, ja absolut! Also ich meine, wie kommt man zum Thema Ernährung? Das ist ja tatsächlich für die meisten Menschen irgendwie das Gewichtsthema und gar nicht so sehr das gesundheitliche. Wir verknüpfen ja in unserer Gesellschaft erstaunlicherweise Ernährung nie mit Gesundheit, oder in ganz ganz wenigen Fällen mit Gesundheit, obwohl es die Grundlage unseres Körper ist. Und insofern, ich hatte ja auch einige Ärzte aufgesucht und da ist ja niemand auf die Idee gekommen zu sagen, ja vielleicht mögen Sie wenn Sie Hautprobleme haben etwas an Ihrer Ernährung verändern. Vielleicht ist da irgendein Problem, ja. Ja ja, nee, also Ernährung – nee hat im Prinzip keine Auswirkung auf die Haut. Julia: Genau, ja, also das ist leider das Credo das man immer hört. Ich habe jetzt auch mit einer gesprochen die hat rheumatoide Arthritis und eben auch mit Ernährung unglaubliche Erfolge. Die ist jetzt mittlerweile, also die ist über 50 und ihrer Altergruppe Europameisterin im Gewichtheben geworden, obwohl die erst seit 5 Jahren trainiert. Da hat sie das erste Mal eine Langhantel in der Hand gehabt, sagen wir mal so. Gewaltig und da auch: Nein mit Ernährung kann man nichts machen. Nadja: Nein, da hat man wirklich, also im Prinzip überhaupt gar keine Chance. Also ich kann hier ein Medikament geben, ne Salbe. Kortison ist ja sehr beliebt bei allen entzündlichen Erkrankungen. Und sobald man dann anfängt die Nebenwirkungsliste zu lesen, denkt man: Och, vielleicht gibt’s noch etwas anderes, ich guck mal bei Google. So fängt dann die Reise glaube ich für viele an. Julia: Ja, wahrscheinlich. Das heißt also für dich praktisch bis zu dem Zeitpunkt wo du einfach gesagt hast, so kann es eigentlich nicht mehr weitergehen, ich muss jetzt irgendwas machen, war das nie ein Thema. Also man hat einfach die Allergien und mit denen lebt man. Das ist praktisch einfach so Gott gegeben mehr oder weniger. Das hat man halt, ja und da ist im Grunde nichts was man tun kann. Das war auch bis dahin also das was du auch vermittelt bekommen hast. Nadja: Ja, ja. Nee, da kann man wirklich, also da kann man überhaupt nichts machen. Man kann Medikamente nehmen, doch, das kann man tun und zwar gegen jede der einzelnen Beschwerden die ich so hatte gab es eins. Also das fängt ja bei den, also bei allem was zum Thema Frauengesundheit, da kriegt man dann die Pille drüber. Das war auch für die mentalen Beschwerden angesagt, so Stimmungsschwankungen und Aggressionen. Ja, wenn Sie so etwas haben kriegen Sie die Pille dagegen. Die hilft auch gegen die Akne übrigens. Auch wenn Ihr Hormonspiegel ganz normal ist. Also da ist ja gar nichts was irgendwie sichtbar ist. Bei den Hautgeschichten und alles was entzündlich ist da kriegt man halt Kortison. Das ist eigentlich das was man tun kann. Und darüber hinaus gibt’s leider nicht so wahnsinnig viel, zumindest nicht wenn man zum Arzt geht, oder bei vielen Ärzten – sagen wir es so. Julia: Ich meine jetzt hast du ja praktisch initial schon viele Verbesserungen gesehen und Erfolge gesehen, was dann sozusagen deinen Hunger nach mehr Wissen geschürt hat und du ja immer weiter und weiter ausprobiert hast. Wie geht’s dir heute? Also was ist dein jetziger Stand von deiner Gesundheit her? Nadjas heutiger Gesundheitsstand, 08:13 Nadja: Also das was ich, ich habe eine Symptomliste. Ich habe gerade die Präsentation für das Webinar nächste Woche auf meinem Kanal vorbereitet und ich dachte so, boah, was du alles gehabt hast – das gibt’s doch gar nicht! Und was übrig geblieben ist, ist Schwachstelle Nase bei mir, immer noch so ein bisschen Schnupfen ab und zu, besonders an stressigen Tagen, also wenn der Kopf irgendwie sagt: So, das reicht jetzt, ich habe die Nase voll – dann ist sie auch wirklich zu. Ansonsten würde ich aber sagen ist eigentlich das Meiste Geschichte, doch wirklich, ja. Also weder Frauengesundheit, das sind alles so Themen, die sind komplett abgehakt. Depressionen in dem Ausmaß wie ich sie gehabt habe, absolut Vergangenheit, Aggressionen Vergangenheit, heftigste Stimmungsschwankungen, alles was so an richtigen – also ich beschreibe das immer mit so einer Welle. Also ich habe wirklich so ein auf und ab gehabt innerhalb des Tages auch, und das ist eigentlich passé zum Glück. Also ich würde sagen, das Meiste was mich mit 29 noch geplagt hat ist heute zum Glück vergessen. Julia: Echt toll, ja super. Wir werden jetzt dann noch im Laufe des Podcasts natürlich noch mehr darüber reden jetzt über die genauen Tipps und Tricks die du so angewandt hast und was man vielleicht im speziellen machen kann. Aber vielleicht vorab, ich denke es ist ganz wichtig, dass du mal erklärst den Unterschied überhaupt zwischen Allergie und einer Unverträglichkeit, weil das wird ja ganz gern in einen Topf geschmissen und ich glaube das ist ganz wichtig, dass du das mal erklärst was da die Unterschiede eigentlich sind. Unterschiede zwischen Allergie und Unverträglichkeit - 09:51 Nadja: Ja, also im Wesentlichen sind das 2 verschiedene Mechanismen eben der Immunantwort kann man so sagen. Also eine Allergie gibt tatsächlich eine Antwort des Immunsystems. Das heißt, all die Zellen die unser Immunsystem so beinhaltet, so Killerzellen und Makrophagen und was es da alles so gibt, die reagieren und versuchen den Eindringling unschädlich zu machen im Zuge einer systemischen Entzündungsreaktion. Das ist bei einer Unverträglichkeit anders. Bei einer Unverträglichkeit ist es so, dass es diese Immunantwort an sich nicht gibt. Es gibt aber trotzdem über andere Mechanismen eine Entzündungsreaktion und das kann manchmal komplett identisch aussehen. Also, es gibt Allergien und Unverträglichkeiten die sehen wirklich total gleich aus von der Symptomatik. Das eine ist nur mit Immunsystem, das andere ohne Immunsystem. Das ist ganz interessant eigentlich. Das Wesentliche, also wie ich es unterscheide, sind eigentlich ja, also eine Allergie ist tatsächlich etwas was ich nachweisen kann, was ich messen kann. Bei einer Unverträglichkeit ist das häufig deutlich schwieriger und die Unverträglichkeit ist auch viel viel einfacher reversibel, um das mal so zu sagen. Also jemand der im Erwachsenenalter eine Unverträglichkeit erwirbt, der kann das mit, also in kürzerer Zeit wieder in den normalen Zustand bringen, als das bei einer Allergie der Fall ist. Julia: Also das sind mal wichtige Unterscheidungen natürlich. Ich denke, ich meine oder wie ist das bei einer Allergie generell so, dass die Reaktion ziemlich akut ist und bei der Unverträglichkeit möglicherweise teilweise 12 oder 24 Stunden später sogar auftreten kann. Ist das auch ein.. Nadja: Also, ja, könnte man sagen. Aber es gibt auch Allergien, die eben nicht zum Soforttyp gehören. Das heißt, da kann auch die Reaktion erst nach 24 Stunden oder nach 48 Stunden auftreten. Da gibt es ganz unterschiedliche Subkategorien auch. Die werden normalerweise nicht untersucht. Ich glaube es gibt 6 Allergietypen. Also normalerweise hat man irgendwie eine die untersucht wird, ein Allergietyp der am weitesten verbreitet ist. Aber es gibt tatsächlich welche, die auch mit einer Spätreaktion kommen, wo es dann tatsächlich mal 24 Stunden dauern kann auch. Also diesen zeitlichen Abstand würde ich jetzt nicht unbedingt als Unterscheidungsmerkmal sehen. Julia: Ja gut, ich denke, dass ist halt auch wahnsinnig schwierig, gerade wenn eine verzögerte Reaktion stattfindet da auch irgendwann einmal drauf zu kommen, dass A mit B zusammenhängt. Ich meine, wenn ich etwas esse und mir schwillt alles an oder ich habe eine wirkliche sofortige Reaktion ist es ja relativ einfach das dann einzukreisen was es ist. Aber ich glaube das macht es auch so wahnsinnig schwierig und wahrscheinlich ist das auch der Grund, warum viele Leute glaube ich auch sehr lange brauchen, um auf so etwas drauf zu kommen, weil es einfach so zeitverzögert oft auftritt. Nadja: Ja, total. Also das ging mir auch so. Also auch in den späteren Jahren, jetzt wo ich wirklich im Thema drin war und wo ich das Gefühl hatte, eigentlich weiß ich was ich hier tue, dass man auf bestimmte Lebensmittel wie Milchprodukte z. B. mit entweder total leichten Symptomen reagiert, die man gar nicht so wahrnimmt. Also wenn ich den ganzen Tag Cappuccino trinke und ich werde immer so ein bisschen müde und trinke dann noch einen Cappuccino und noch einen Cappuccino, dann reagiere ich vielleicht oder dann ist mir gar nicht so richtig klar, dass die Milch eigentlich mich müde macht, die ich da die ganze Zeit trinke. Die Reaktion ist auch nicht immer so deutlich wie man das jetzt bei einem anaphylaktischen Schock bei einer Allergie eben tatsächlich auch mitkriegen würde. Ja, das macht das Ganze auch wirklich schwierig, das mit Lebensmitteln überhaupt in Verbindung zu bringen. Julia: Ja voll. Ich meine vielleicht weil du es eben gerade schon angesprochen hast das Thema – wie können sich, weil du hast es nur so umrissen, wie können sich jetzt so Allergien und Unverträglichkeiten äußern? Weil viele Leute denken ja wirklich nur an entweder ‚Ich schwell auf und schaue aus wie ein Kugelfisch’, ja, oder halt Hautausschläge, Juckreiz, massiven Durchfall vielleicht oder Bauchschmerzen, ja. Aber du hast das ja schon angeschnitten, da gibt’s ja eine Vielzahl an anderen Symptomen. Vielleicht kannst du da mal so bissel einen Überblick geben, damit man auch sensibel wird und weiß auf was man schauen muss. Mögliche Symptome, 14:14 Nadja: Also im Prinzip kann man bei beiden, sowohl bei Allergien als auch bei Unverträglichkeiten tatsächlich eigentlich alles was an systemischen Entzündungen im Körper passieren kann als Symptom mit nehmen. Das fängt an natürlich, also wie du schon sagtest mit der Haut. Das sind so typische allergische Orte sage ich jetzt mal, also Hautausschläge, Ekzeme, Nesselsucht, was es da alles so gibt. Da gibt’s ja ganz ganz verschiedene Symptomatiken auch. Die sind eigentlich meines Erachtens immer mit irgendeiner Fehlleitung des Immunsystems oder irgendeiner Reaktion des Immunsystems verbunden. Dann gibt es alles Mögliche an mentalen Erscheinungen, d. h. alles was Müdigkeit, Erschöpfung, Depression, Angstzustände, Panikzustände, also das kann ganz ganz unterschiedliche mentale Auswirkungen auch haben. Das ist das, was mich eigentlich am allermeisten auch beschäftigt hat in den letzten Jahren, dass das so ist und keiner darauf guckt. Also das hat mich wirklich am meisten erschrocken. Die Leute kriegen Psychopharmaka verschrieben und keiner guckt irgendwie, gibt’s da irgendein Allergen was da eine Rolle spielt. Also nicht nur Lebensmittel, sondern auch andere Umweltgifte, auf die vielleicht allergisch reagiert wird. Dann Gelenkschmerzen, alles was in diese Kategorie fällt, also Einschränkungen des Bewegungsapparates das kann passieren. Das ist bei mir z. B. eine klassische Glutenreaktion gewesen so Gelenkschmerzen in den Knien. Auch heute, wenn ich ein Bier mir traue zu trinken, dann kriege ich das auch noch. Ja, also zumindest habe ich es eine ganze Zeit lang. Mittlerweile geht’s ganz gut. Aber also eine ganze Zeit lang habe ich echt mit heftigen Knieschmerzen reagiert auf ein Bier. Das sind ja so Sachen, das ist den Leuten nicht klar. Das ist einfach so, weil es total ungewöhnlich ist, eher subtil ist und einfach nicht mit unserem Essen in Verbindung steht, fertig. Was haben wir denn noch so? Also da haben wir natürlich alles was an Frauengesundheitsgeschichten ist, also Myome, Regelschmerzen, PMS, polyzystisches Ovarialsyndrom. Überall spielen eigentlich, also eigentlich kann das Immunsystem einfach überall angreifen. Es ist so. Offensichtlich gibt’s da vielleicht einen Teil genetische Disposition an welchen Stellen das der Fall ist, aber also im Prinzip kann der ganze Körper zur Zielscheibe werden sozusagen, ja. Julia: Wahnsinn, ja. Das heißt, da muss man sich einfach sehr sehr gut beobachten denke ich mal. Nadja: Ja, ja, ja. Julia: Was ist jetzt deiner Meinung nach, ich meine du hast eben Ernährung auch oft angesprochen, was ist so deiner Meinung nach jetzt so ganz zentral, wenn es darum geht‚ ja, ich möchte allergiefrei werden oder ich möchte einfach auch mal dahin kommen wo du jetzt bist. Wichtige Schritte für ein allergiefreies Leben, 17:06 Nadja: Ok, also Nr. 1 ist Geduld! Julia: Ok, da wird’s schon schwierig. Nadja: Da wird’s schon schwierig. Ja, ich habe ja Schmerzen oder ich habe irgendwelche Beschwerden. Das ist natürlich, dann habe ich meistens nicht so wahnsinnig viel Geduld. Also es ist eine Sache vielleicht vorweg. Bevor man das so sagt oder bevor man das jetzt erläutert, ist ja, was ja viele deiner Zuschauer sicherlich auch wissen, dass das Immunsystem eigentlich zentral im Darm angesiedelt ist. Das heißt bis zu 80 % unserer Immunzellen tummeln sich in unserem Verdauungstrakt und deswegen ist das eigentlich auch der Punkt auf den man ganz genau gucken sollte. Selbstverständlich in erster Linie bei Lebensmittelallergien und Unverträglichkeiten spielt der Verdauungstrakt eine Rolle. Und um den sollte man sich auch kümmern. Also alles was dem Darm und in erster Linie unserem Mikrobiom, also unsere Bakterien, unseren Mitbewohnern sozusagen nützt, nützt auch uns und unserem Immunsystem. Da gibt’s eine ganz ganz enge Verbindung zwischen dem Mikrobiom und unserem Immunsystem. Die kommunizieren die ganze Zeit miteinander. Die kommunizieren mit unseren Darmzellen. Die kommunizieren mit unseren Immunzellen, also in den Zwischenräumen der Darmschleimhaut usw. Und wenn das ein bisschen außer Kontrolle geraten ist aus unterschiedlichen Gründen - Medikamente, Alkohol, Stress sind so die wesentlichen Punkte glaube ich, Fehlernährung natürlich – dann wird es schwierig und dann ist tatsächlich der Fokus auf das Mikrobiom und auf das Immunsystem im Darm eigentlich das Wichtigste was man machen kann. Da gibt es verschiedene Ansätze die man wählen sollte und der Erste ist selbstverständlich die Ernährung anzupassen. Also weg von Zusatzstoffen, Konservierungsstoffen die das Immunsystem schädigen, bei Konservierungsstoffen immer noch die Frage, tötet das auch unser Mikrobiom? Das ist ja tatsächlich auch so ein Thema. Julia: Ja, natürlich ja. Nadja: Zucker – alles was süß ist nährt natürlich die Hefen und Pilze in uns und auch die nicht so günstigen Bakterien. Die freuen sich wahnsinnig über so einen Schokoriegel. Das ist natürlich das, was man dann als erstes irgendwie auch abschalten sollte und Dinge die tendenziell fordernd sind für das Immunsystem. Wenn die Darmschleimhaut kaputt ist, dann erst recht, wie eben Milchprodukte, Gluten, solche Sachen, ja. Julia: Würdest du persönlich grundsätzlich zu Gluten sagen, auf jeden Fall, also egal wie sich die Allergie äußert, Gluten sollte auf jeden Fall raus? Nadja: Ich bin mir ehrlich gesagt, also ich bin ja großer Fan der Paleo-Ernährung und lebe das ja auch selber jetzt seit eigentlich 5 Jahren und ich komme da auch, also ich komme da einfach auch im Kopf nicht mehr ran. Aber ich weiß, dass es nicht für jeden notwendig ist, das für immer sein zu lassen, sondern dass es auch Menschen gibt, die bestimmte Produkte nachher wieder vertragen können. Ich würde das, also und das tue ich bei meinen Klienten auch nicht, zu sagen, pass auf, das muss für immer aus deinem Speiseplan gestrichen werden. Das ist nicht der Fall. Aber es macht auf jeden Fall total viel Sinn, das für einige Wochen mal zu tun und dem Immunsystem und dem Darm die Möglichkeit der Regeneration zu geben. Julia: Da hast du was ganz wichtiges noch angesprochen, nämlich eben dass sich die Ernährung auch verändern kann, also dass es initial vielleicht strenger sein muss oder soll und sich dann eben auch, man sich wieder mehr vielleicht auch erlauben darf wie du sagst, ein Bier. Nadja: Geht auch immer wieder – nee, genau, also ich denke einfach, dass es auch psychologisch total sinnvoll ist zu sagen, pass auf, es ist nicht so, dass du nie wieder essen darfst oder so. Ja, das macht den Leuten Angst, das ist doch klar. Ich meine was mache ich mit der Familienfeier nächste Woche Donnerstag? Und alle essen Kuchen, und ich soll da dasitzen und soll das nicht tun. Aber wenn du schnell Ergebnisse erzielen willst über die Ernährung, dann sind bestimmte Sachen für einen Zeitraum X total sinnvoll. Und das Zweite, was zum Thema Gluten gerade echt zu sagen ist – und das habe ich auch in meinem Buch noch ein bisschen ausführlicher erklärt – ist eigentlich gar nicht so sehr das Brot selber und das Gluten selber vielleicht, sondern alles was in diesen Produkten die wir kaufen drin ist. Und das ist ja nicht nur Getreide, sondern das sind ich weiß nicht 200 Zusatzstoffe die dort schon für Brot erlaubt sind z. B. Weiß der Kuckuck wer da auf was reagiert! Das weiß wirklich kein Mensch, und selbst wenn jeder einzelne Zusatzstoff erlaubt ist, hat Tante Klara vielleicht ne Reaktion auf Enzym XYZ und der Nächste auf Enzym CDEF. Das ist eigentlich, also diese Produkte sind für mich ein großes Problem, mehr noch als zu sagen – pass auf, kauf dir ne Tüte mit Dinkelkörnern, mahl es selber, back dein Brot. Julia: Genau, also das sehe ich auch so wie du, vor allem aus Großbäckereien oder jeder Bäcker, der nicht wirklich das eben selber mahlt und selbst von Hand ein Brot macht und jetzt vielleicht auch noch der Zeit gibt zum Sauerteig machen, Sauerteigführung mit 40 Stunden Gehenlassen und so. Man muss ja eben denken diese Zusatzstoffe die du erwähnt hast. Die ganzen Teige müssen mit Maschinen verarbeitbar sein und da sind diese speziellen Zusatzstoffe auch drin und die werden eben gar nicht deklariert, ja. Nadja: Total, ja. Also gerade was Maschinenarbeit angeht, wird auch tatsächlich Gluten zugesetzt noch, also zu dem was sowieso drin ist im Getreide wird Gluten zugesetzt, damit das noch ein bisschen fluffiger wird das Ganze. Also da spielen so viele Faktoren auch eine Rolle. Wir reden jetzt gerade auch in der Presse über Glyphosat. Also das sind natürlich Themen, die da irgendwie eine Rolle spielen. Dann haben wir was viele ja nicht wissen in den Getreidesilos was da begast wird und was da gesprüht wird, damit da kein Ungeziefer rangeht. Das ist alles da drin. Das darf man nicht vergessen. Und wir gucken immer nur und sagen ja glutenfreie Ernährung. Es geht nur zum Teil um das, was an Gluten im Weizen drin ist. Es geht, also für mich persönlich, zu einem großen Teil um alles andere was da noch so drin ist. Für mich sind das Chemielabore. Das sind chemische Produkte im Prinzip was da beim Bäcker liegt. Julia: Ich glaube das ist auch ein Grund, warum aus den Studien was wenn sie dann Vergleiche mit Placebo machen und glutenfreier Ernährung und die Leute es nicht wissen und dann kommt da immer raus, die haben deswegen genauso Beschwerden oder es ist ja auch gar nicht viel besser. Und dann wird’s ja oft so dargestellt, als wäre das alles eine Einbildung. Jeder der nicht Zöliakie hat der darf gar nicht auf Gluten reagieren. Ich denke, dass da eben die Diskussion in die falsche Richtung geht, weil was nehmen die dann? - Andere stark verarbeitete Produkte, die halt so tun, als wären sie ein Brot aus Getreide! Dafür sind sie halt aus irgendwelchem anderen Klump, ja, das stark verarbeitet ist. Und ich glaube das passt sehr gut in das, was du gerade gesagt hast. Vielleicht liegts nicht nur an dem, sondern eben an all diesem anderen Zeugs was da drin ist. Nadja: Ja total, ja ja klar. Also da gab’s neulich wieder irgendwas, glutenfreie Ernährung ist nicht besser. Und dann haben die Leute die glutenfreien Produkte gegessen und man denkt sich so, ok, das kann’s jetzt irgendwie nicht gewesen sein. Julia: Aber da kann man sich wirklich teilweise nur an den Kopf greifen bei der Diskussion. Jetzt abgesehen von Ernährung – welche anderen Maßnahmen würdest du sagen sind wirklich wichtig, weil du hast das ja schon auch angesprochen, dass z. B. Stress eine Rolle spielt. Also wo setzt du noch an oder was hast du bei dir auch gesehen? Was schreibst du in deinem Buch, welche anderen Maßnahmen sind wichtig? Weitere wichtige Maßnahmen, 24:53 Nadja: Ja ich glaube, dass die Psyche auf jeden Fall eine ganz ganz große Rolle spielt, insbesondere beim Thema Unverträglichkeiten. Wir leben heute in einer Gesellschaft und das war auf der Paleo Convention, da hat Ötzi von Primal State das wunderschön gesagt: Man kann ganz viele Sachen ausgleichen, eine schlechte Ernährung mit einem guten Lebensstil und mit vielen Freunden und sozialem Gefüge usw. kann man gut ausgleichen. Das einzige was man nicht gut ausgleichen kann ist Einsamkeit. Das kann man nicht mit Sport, das kann man nicht mit super Ernährung oder irgendetwas anderem ausgleichen. Und wir leben in einer Gesellschaft, die tendenziell ja naja eigentlich sehr einsam ist. Wir haben unsere kleinen Familienverbände. Wir haben facebook und wir versuchen vieles mit uns selber auszumachen. Also ich möchte mich niemandem öffnen. Ich möchte mich niemandem zeigen. Ich möchte meine Probleme nicht diskutieren, meine Ängste, meine Sorgen. Ich könnte verletzbar werden und darüber werden viele Leute krank. Also das hat auf mich, also für mich war das auf jeden Fall ein Thema zu sagen, ok, ich habe jetzt hier eigentlich überhaupt gar keinen mehr so richtig dem ich vertrauen kann oder dem ich mich öffnen kann und will. Und das ist eine schwierige Sache. Das passiert auch selbst wenn man verheiratet ist oder selbst wenn man irgendwie in einer Partnerschaft lebt und alle sind irgendwie so Vollgas unterwegs in ihren Lebensthemen, beruflich. Man versucht Karriere zu machen. Man will stark sein und irgendwann geht das einfach. Irgendwann ist das einfach zu viel unter Umständen und ich finde das super wichtig, gerade dieser Alterswechsel von den 20ern in die 30er, wo sich ziemlich viel verändert im Leben. Manche kriegen Familie, der andere versucht beruflich auf die Beine zu kommen und da passiert ganz viel auch mit unserer Persönlichkeit mit dem wie wir sind. Das kann alles dazu beitragen, dass wir ein unwahrscheinliches Stresslevel aufbauen ohne das zu merken. Also wie gesagt, für mich war das auf jeden Fall so ein großes Problem. Ich halte das immer noch für wichtig, also diese Psychohygiene wie man das so schön nennt, sozialer Abgleich, sich mit Menschen zu unterhalten, sich mit Menschen auszutauschen, eine Freundin zu haben der man sagen kann, pass auf, eh mir geht’s heute echt Scheiße. Ich weiß nicht wo ich hin soll. Ich weiß nicht was ich machen soll. Ich fühle mich nicht gut. Das ist super wichtig; das ist unwahrscheinlich wichtig. Ich glaube in den Städten ist das ein großes Problem wo viele alleine sind. Ja, und wir sind halt weg von unserer Familie. Das ist es ja auch. Also meine Familie ist 500 km weiter weg. Ich sehe sie relativ selten und höre sie auch verhältnismäßig selten und so entwickelt sich so etwas einfach, ohne dass man das vielleicht auch merkt. Und bei Allergien ist es, gerade diese ganzen Hautprobleme, sagt man natürlich auch bei den psychosomatischen Sachen ist das jetzt was, wo einfach die Grenze überschritten ist, wo nicht mehr klar ist, was bin ich eigentlich und was ist meine Umwelt. Was gehört zu mir? Was bin ich als Person und was ist meine Umwelt? Das ist ein sehr naturheilkundlicher Ansatz. Das ist ganz klar. Da wird kein Hautarzt danach fragen. Julia: Und der sagt ja auch, Ernährung hat auch nichts zu tun damit. Nadja: Aber die Ernährung hat ja auch nichts damit zu tun – genau, richtig! Ja insofern, also die Psychohygiene und dieses welche Gedanken habe ich, wie geht’s mir tatsächlich auch emotional, spielt eine ganz ganz große Rolle für mich. Julia: Was hat dir da besonders geholfen? Ich meine es gibt ja sehr viele verschiedene Ansätze und Möglichkeiten. Was hat dir da am meisten geholfen oder was hast du auch für Erfahrung vielleicht mit anderen Leuten gemacht, die vielleicht einen anderen Ansatz gewählt haben? Nadja: Ja, andere Ansätze kann ich gar nicht so sagen. Also definitiv diese Gedankenüberprüfung - also die wurde in dem Buch „The Work“ von Byron Katie vorgestellt, die ich super effektiv finde - jedes blödsinnigen Gedankens der mir so im Kopf irgendwie mal auftaucht oder so was. Man neigt ja dazu zu glauben was man denkt. Und das ist natürlich totaler Blödsinn in vielen Fällen. Das steht bei mir übrigens hier groß im Büro an der Wand „Glaube nicht alles was du denkst.“ Das ist das eine, das andere ist Yoga auf jeden Fall, also Yoga und Meditation als verbundene Sache hat mir sehr sehr geholfen zur Ruhe zu kommen, atmen zu lernen und einfach ruhig zu werden. Julia: Hast du einen Tipp wie man, also wie gesagt viele können sich ja das gar nicht so richtig vorstellen mit Meditation und so und es ist vielleicht auch, wie kommt man da am besten rein oder wie macht man das am sinnvollsten? Nadja: Ja gut, also gerade wenn man so ist wie ich. Ich bin ja sehr schnell und sehr husch husch husch und der Kopf rast die ganze Zeit hin und her. Da ist 5 Minuten hinsetzen und Klappe halten und atmen echt schwer, gefühlte Meditation. Also mir muss schon einer einen Text vorgeben, hilft total viel. Also jetzt achte auf deine Atmung und jetzt stell dir vor und jetzt das und jetzt dieses. Julia: Das heißt dann über Kopfhörer? Nadja: Über Kopfhörer, ja, ganz genau, ja. Also entweder man hat ne gute Box die man am Bett stehen hat oder eben über Kopfhörer, genau. Und das kann ich auch im Büro machen jederzeit. Kopfhörer auf und ok 5 Minuten, und das ist echt ne total hilfreiche Sache, also ich finde ich persönlich und wichtig. Julia: Hast du etwas was du empfehlen kannst, weil es gibt ja auch so viele so Apps? Nadja: Ja, ich glaube in Deutschland sind wir gerade mit Seven Mind ist glaube ich eine deutsche App bin ich der Meinung. Ich bin sehr verliebt gewesen in Kim Fleckenstein, die get-on-Apps macht und da irgendwie so ein ganzes Portfolio zu allen möglichen Lebenszielen auch hat. Laura Seiler ist natürlich, ja, macht ganz ganz tolle freie Meditation, die man im Podcast runterladen kann und ja das sind eigentlich so die wesentlichen Sachen. Dann gibt es noch so ein paar Hypnosegeschichten. Das ist für mich ein relativ neues Thema, ist aber bei Allergien super effektiv. Also das ist richtig heftig finde ich was man da machen kann. Julia: Aber da muss man, meinst du jetzt Selbsthypnose oder müsste man da jemanden finden der das macht? Nadja: Ich bin da gerade so ein bisschen im Austausch mit verschiedenen Leuten und versuche das gerade so rauszufinden, was ist da eigentlich. Also ich habe eine Audioproduktion benutzt. Ich habe tatsächlich allergische Symptome auch auf Kälte und solche Sachen gehabt. Ich habe heute Morgen das erste Mal kalt geduscht. Ich bin total stolz und mir geht’s gut. Also ich habe keine Reaktion gehabt. Das war ein bisschen mutig, das heute auszuprobieren wo ich mit dir rede. Ich bin aber ok, hat ganz gut funktioniert. Also ich habe eine Audioproduktion, die ist auch im Buch empfohlen, kann man im Internet unter „schneller Allergieprozess“ finden. Da geht’s im Wesentlichen darum, dass man sagt, ok das Immunsystem reagiert auf ähnliche Sachen nicht, reagiert aber auf diese Sache und jetzt bringt man über einen Mentalprozess dem Immunsystem bei, auf das Allergen so zu reagieren, wie auf die Sache die so ähnlich ist, aber auf die es nicht reagiert, um das so grob zu sagen. Julia: Wahnsinn! Nadja: Ich bin nach der ersten, nachdem ich das das erste Mal gehört habe, bin ich aufgewacht und dachte, das kann jetzt nicht wahr sein, übel echt, weil ich dachte so, das kann jetzt überhaupt nicht sein! Also ich habe das echt gefühlt, dass das jetzt besser wird und dass das weg ist zu einem Teil. Ich habe es hingekriegt über den gleichen Prozess rückwärts wieder ‚Das kann nicht wahr sein, das kann nicht wahr sein, das kann nicht wahr sein.’ Julia: Das geht auch. Nadja: Das geht auch, funktioniert auch umgekehrt, genau. Kann ich sehr empfehlen, das einmal auszuprobieren und es gibt natürlich Hypnotiseure die das auch machen. Julia: Aber alles auch, ich meine wenn man jetzt so noch gar nie etwas mit Meditation oder mit autogenem Training oder all diesen Dingen zu tun hatte oder egal was es halt gibt an Techniken, um mit dem Stress z. B. fertig zu werden – hast du da auch, oder was ist deine Erfahrung so im Schnitt, wie lange braucht das, bis man sich da auf das einlassen kann? Oder kann man das überhaupt nicht sagen? Oder sagt du, also man muss es schon mindestens eine Woche jeden Tag sich darauf einlassen, das machen und dann geht’s schon viel leichter oder was kannst du da sagen? Nadja: Ja das ist ja ähnlich wie bei der Ernährung. Also man muss die Sachen natürlich üben, das ist so. Aus meiner eigenen Erfahrung und so wie ich an dieses ganze Thema auch rangegangen bin, ist der erste Schritt, sich zu erlauben, dass das eine Möglichkeit sein könnte, besser mit diesen Themen umzugehen. Denn ich habe ganz ganz lange an der Ernährung festgehalten und habe gesagt, auf gar keinen Fall hat das irgendetwas mit meinem Kopf zu tun, also auf keinen Fall. Während mein Mann die ganze Zeit gesagt hat, das ist nur hier, nur hier, nur hier. Und ich habe gesagt, nein, das liegt am Essen. Und ich glaube der erste Schritt ist echt, zu sagen, ok jetzt isst du so perfekt oder es kann ja nicht sein, dass ich da so reagiere und alle anderen um mich herum nicht, was ist denn da los? Es besteht die Möglichkeit, dass es in meinem Kopf ist. Wenn man an dem Punkt angekommen ist und sagen kann, ok, es kann sein, dass es hilft und wenn es hilft, dann habe ich es nicht ausprobiert, weil ich zu eitel bin und glaube, dass ich eigentlich ganz gesund bin, obwohl ich’s nicht bin. Verdammt, Kopfhörer auf, ausprobieren! Eine Woche lang irgendwie vor dem Schlaf oder nach dem Aufwachen morgens sich irgendwas raussuchen und das machen und mal gucken, wie es einem so geht damit. Ich glaube das ist so nach 3 – 4 Tagen klar, dass es einem ziemlich gut damit geht, weil man einfach mal richtig gut zur Ruhe kommt und insofern, also ich glaube so wahnsinnig lange braucht das nicht, um einen da zu überzeugen. Julia: Ok. Ich meine jetzt wie gesagt, du hast so viele Ansätze jetzt genannt. Wenn jetzt jemand eben so ganz neu bei dem Thema ist, was ist deiner Meinung nach so die, was sind die ersten wichtigsten Schritte, wo du sagst, damit mal anfangen, dann hat man schon die ersten Erfolge und dann nach und nach sich die anderen Themen vielleicht erarbeiten? Die ersten wichtigsten Schritte, 35:08 Nadja: Also die erste Fragestellung ist natürlich immer, habe ich überhaupt eine Allergie und eine Unverträglichkeit? Ich glaube das ist eigentlich so der wichtigste Schritt. So ok, ich habe alle möglichen Beschwerden, wie auch immer. Ich führe jetzt mal Tagebuch, ich gucke mir das jetzt mal eine Woche an. Ich schreibe auf was ich esse, wann ich esse und wann meine Symptome denn so auftreten, weil es juckt dann irgendwie mal und dann kommt mal dies und dann kommt mal jenes und dann gucke ich in den Spiegel und habe plötzlich 4 Pickel im Gesicht oder so. Was habe ich denn ein paar Stunden vorher gegessen? Und dann kann man und das kann man mit den Lebensmittellisten machen die im Buch sind z. B., gucken so wo passt denn das eigentlich rein. Also was könnte das sein? Sind das jetzt Milchprodukte die mir Beschwerden machen oder sind das besonders histaminreiche Produkte? Sind das vielleicht Salicylate? Ist es jedes Mal wenn ich Brot gegessen habe oder wenn ich Müsli gegessen habe oder irgendwas in der Richtung? Was könnte das eigentlich sein? Ich glaube das ist so der erste Schritt, um ein Gefühl dafür zu kriegen, ob das überhaupt etwas mit der Ernährung zu tun hat bzw. ob es eine Allergie oder eine Unverträglichkeitsreaktion sein könnte. Und dann ist natürlich klar Darmsanierung angesagt und Ernährungsumstellung, Eliminationsdiät – d. h. auf diese Sachen auch wirklich zu verzichten für Zeitraum X, bzw. sie soweit zurückzuschrauben, dass das keine belastende Menge mehr ist. Da kann man vielleicht unterstützen mit Nahrungsergänzungsmitteln, mit Bakterienkulturen, mit fermentierten Lebensmitteln sofern das möglich ist, die ich immer noch am effektivsten finde. Das ist eigentlich so, das sind so die Schritte, die man dann geht und bei Unverträglichkeiten kann man so mit einem halben Jahr schon rechnen, dass man sich irgendwie so ein bisschen an dieses Thema auch halten muss und da echt etwas machen muss, bis das wieder so einigermaßen im Lot ist. Julia: Du hast das vorhin ganz kurz angesprochen: Eben wenn man weiß, dass man XY hat, eine Nahrungsunverträglichkeit oder eine Allergie und natürlich wir haben die Symptome und du leitest ja auch in deinem Buch, also gibt es auch eine Anleitung oder auch eine Auflistung der möglichen Symptome, was man alles haben kann. Aber wie schaut es denn mit sozusagen diesen schwarz auf weiß Labortests aus? Was gibt’s denn da? Gibt’s da etwas überhaupt? Haben die Aussagekraft oder nicht? Oder kann man wirklich nur auf sich selber hören? Potential von Labortests vs. Selbsteinschätzung, 37:43 Nadja: Ja das ist eine sehr berechtigte Frage, weil das tatsächlich nicht so einfach ist. Also es gibt Allergietests und die sind ja, also sie werden gemacht – sagen wir es mal so – die sind auch ziemlich aussagekräftig. Aber da eben nicht alles eine Allergie ist, ist an dem Ende schon wieder Schluss. Das Wichtigste ist eigentlich meines Erachtens auch die Allergie auszuschließen. Selbst das ist ein Schritt, der ist super wichtig. Denn der anaphylaktische Schock der da entstehen kann, der führt zum Tod. Das ist ganz einfach. Wenn ich nicht weiß, dass es eine Allergie ist oder ob es eine Allergie ist oder eine Unverträglichkeit, dann weiß ich auch nicht, muss ich das Notfallset mit mir herumtragen, falls ich doch irgendwie mit dem Lebensmittel in Kontakt komme aus Versehen vielleicht. Julia: Ja, natürlich. Nadja: Oder, oder, oder. Also das sind so Fragestellungen, die müssen geklärt werden, auch wenn das frustrierend ist am Anfang, weil die sagen ja ‚Sie haben keine Allergie’ und schicken einen wieder nach Hause. Ja und dann kann man froh sein. Dann kann man das abhaken und sagen ‚Ich habe keine Allergie, das ist toll.’ Das ist viel besser, weil die Unverträglichkeit ist sehr viel einfacher. Und dann geht man vielleicht noch die Tests durch, den H2-Atemtest für die Laktose- und die Fruktoseintoleranz. Je nach dem was da rauskommt, der ist offensichtlich auch nicht so super aussagekräftig, aber ich sage jetzt mal im Großteil der Fälle ist er das. Und ja, dann halt das Ausschlussverfahren, also Eliminationsdiät und gucken und danach wieder einführen vielleicht mal nach einer Woche oder vielleicht nach 2 Wochen gucken, so, reagiere ich jetzt da drauf, wenn ich das jetzt wieder esse. Das ist eigentlich, also der Goldstandard in der Medizin wäre auch zu sagen, pass auf, du gehst morgen in die Klinik, du isst das eine Woche lang nicht und nach einer Woche kommt der Arzt, gibt dir das und guckt was passiert. Das wäre so der absolute Goldstandard. Aber wenn du weißt, dass es keine Allergie sein kann und du kannst sagen ok, es ist eine Unverträglichkeit, dann kannst du das auch selber testen. Das ist dann halt „Scheiße“, weil du reagierst darauf und es ist unangenehm, aber du kannst das für dich beschließen, dass du darauf reagierst. Das ist in Ordnung. Ich bin damals losgegangen und hab eine Ernährungsberaterin gehabt und habe gesagt, pass auf, ich habe das Gefühl ich reagiere auf das und das und das und das. Und dann sagte sie, nein, das ist völlig überbewertet mit den Histaminen. Das kann überhaupt nicht sein. Ich kann nichts für dich tun. Und dann dachte ich so, ok, also sie ist die Expertin, spricht mir meine Körperbeobachtung ab. Was mach ich denn hier? Was mach ich denn jetzt? Und das möchte ich eigentlich den Leuten mitgeben, dass sie auch sich selber vertrauen können und dass der Arzt oder der Ernährungsberater oder der Heilpraktiker oder wer auch immer da vor einem sitzt auch nur ein Mensch ist und noch dazu ein Mensch, der nicht in deinem Körper drin steckt. Also das ist ganz einfach, also man kann sich selber vertrauen, total und auch irgendwie selber sagen, ok, ich habe das an mir beobachtet, das ist Scheiße so. Julia: Was hältst du eigentlich von jetzt diesen Nahrungsmittelunverträglichkeitstest, also wie IGE und…? Nadja: Ich glaube ich habe sie nicht erwähnt weiter. Julia: Weil das mich jetzt noch persönlich interessiert. Weil du hast, ich denke, dass du dich ein bissel sicherlich irgendwie damit beschäftigt hast oder es dir auf jeden Fall untergekommen ist. Ich will wissen, was deine persönliche Meinung einfach oder deine Erfahrung damit auch ist vielleicht. Einschätzung von Nahrungsmittelunverträglichkeitstests, 41:08 Nadja: Also es gibt diese Tests. Ich halte nicht besonders viel davon. Also das ist ein schwarz auf weiß wenn man es haben will oder so. Also es gibt diese IgG4-Tests, die viele Heilpraktiker machen. Das ist glaube ich noch ein Thema was erwähnt werden darf oder was ich selber für wissenschaftlich valide genug halte zu erwähnen, sagen wir es mal so. Da ist es so, dass die Ärzteschaft das nicht so gerne sieht und sagt, das hat irgendwie keine Aussagekraft. Die Heilpraktiker arbeiten aber damit und haben auch ganz gute Erfolge damit. IgG4 ist ein Immunmarker im Prinzip der ansteigt, auch wenn man das Lebensmittel sehr sehr häufig konsumiert. Das heißt, wenn ich oft Brot esse, dann habe ich natürlich eine Reaktion darauf, weil im Prinzip alles was an Fremdstoffen in den Körper kommt mit einer Immunantwort beantwortet wird. Ich denke IgG4 kann helfen, man sollte das jetzt nicht unbedingt, das ist jetzt kein Nachweis einer Allergie oder einer Unverträglichkeit. Julia: So als Dogma sozusagen ist es jetzt nicht so das einzige. Nadja: Ja, ganz genau, aber es zeigt schon, dass man gewisse Ernährungsgewohnheiten hat und dass man vielleicht etwas vielfältiger konsumieren darf in Zukunft. Julia: Genau. Und noch auf eine Sache, die du vorhin auch noch kurz sozusagen angerissen hast, weil du gemeint hast, man könnte Nahrungsergänzungsmittel nehmen, Probiotika oder was auch immer. Hast du da selber Erfahrungen oder würdest du sagen, eigentlich muss das nicht unbedingt sein oder gibt’s da was, wo du sagst, ja das kann ich wirklich empfehlen oder das hat für dich gut funktioniert? Erfahrungen mit Nahrungsergänzungsmitteln, 42:51 Nadja: Ja also es ist natürlich immer eine individuelle Entscheidung. Das ist ganz klar. Also man solle das normalerweise eigentlich auch mit jemandem absprechen, der da so ein bisschen Ahnung von Mikronährstoffen hat, also wie du jemand bist, Mikronährstoffcoach oder Orthomolekularmediziner – ein schönes Wort. Aber es geht natürlich in erster Linie auch heute immer um das Thema Symptome, wie kriege ich die jetzt weg. Also das ist ja unsere Tablettenmentalität die wir so haben, und wir wollen diese Sachen nicht mit uns rumschleppen und wir wollen nicht, dass es uns juckt ständig und wir wollen natürlich auch nicht das die Nase läuft usw. Also für mich hat gut funktioniert, und das ist auch etwas was ich weiterhin, wo ich echt Wert darauf lege, ist Omega 3, also Omega 3 Fettsäuren, um das Immunsystem und auch die Psyche zu stabilisieren. Also das ist echt ne gute Sache, ein gutes Fischöl sich zu besorgen oder Krillöl oder mittlerweile gibt’s auch Algenöl, was vegan ist. Also da muss man jetzt nicht mehr unbedingt auf Fische zurückgreifen. Ja, das ist eigentlich das Wichtigste. Ich hatte eine Histaminintoleranz. Also für mich war L-Methionin als Aminosäure relativ wichtig und Vitamin C in rauen Mengen. Das war wirklich ganz lange – ja so ungefähr. Ja also wenn du in einer Umgebung bist, wo du weißt, dass du reagierst, dann konsumierst du deine 5, 6, 7, 8 g Vitamin C am Tag bis der Durchfall kommt. Das ist ja dann wie das Symptom dafür, dass man zu viel davon hat. Aber du hast dafür keine anderen Beschwerden, also funktioniert halt ziemlich gut. Also Vitamin C ist echt ne super Sache. Dann haben wir natürlich einige andere Sachen noch die das Immunsystem stärken, wie Vitamin D. Wobei ich da natürlich auch dafür plädiere, dass man rausgeht im Sommer, anstatt Tabletten einzuwerfen. Julia: Ja, Licht. Nadja: Genau. Also das sind so die wesentlichen wichtigsten Sachen eigentlich. Was Präbiotika angeht und Probiotika, das ist ja auch noch so eine Frage, bin ich ein großer Fan von Fermenten, weil wir noch nicht genau wissen, wie wir das industriell so abwägen können, dass es uns wirklich nützlich ist. Und wenn es möglich ist und man keine Histaminintoleranz hat, dann auf jeden Fall Fermente in die Ernährung einbauen. Julia: Fermentierst du selbst? Nadja: Ja, ja. Ich habe mit allem möglichen experimentiert, und ich bin jetzt so bei Gemüsefermenten. Also viele trinken ja Wasserkefir oder Kombucha oder was man da so haben kann. Je nach dem was man so mag, also ja, da gibt es tolle Sachen. Julia: Ja, toll. Ja Naja, vielen herzlichen Dank. Ich meine wir haben jetzt wirklich einen wunderschönen Querschnitt bekommen über dein über diese Jahre angesammeltes Wissen, das du in deinem neu erschienenen Buch „Allergiefrei“ publiziert hast. Wo kriegt man das Buch? Bezugsquellen für Nadjas Buch „Allergiefrei“, 45:55 Nadja: Also erst mal damit es alle gesehen haben: So sieht es aus, und ihr könnt es bei amazon bestellen, ist im Selbstverlag erschienen, wird on demand gedruckt und direkt zu dir ins Postfach geliefert. Das geht super schnell. Oder als Kindle-Version ist es in Sekunden auf deinem Tablet-Reader, was auch immer du hast. Und ja, also amazon in erster Linie und ich glaube auch in wenigen Tagen müsste es auch über den Buchhandel bestellbar sein für alle die den großen Online-Riesen nicht unbedingt vertrauen, was auch immer, ihre Zahlungsdaten geben wollen. Die können es auch über den Buchhandel bestellen. Julia: Ok, super. Ja ich meine das tolle halt an dieser Möglichkeit ist, dass es eben wirklich, auch vom Umweltgedanken her, erst gedruckt wird, wenn es auch wirklich bestellt ist. Nadja: Toll, oder? Julia: …und man die Möglichkeit hat, das im Eigenverlag zu publizieren solche Dinge. Nadja: Ja richtig, ganz genau. Julia: Ja cool. Natürlich werden wir verlinken - das ist eh ganz klar - zu dir, zum Buch, wo man es bekommt. Noch mal auch die Dinge die du erwähnt hast würde ich ganz gerne verlinken, dass wir dann alle Ressourcen zusammen haben. Ja, dann vielen herzlichen Dank für deine Zeit! Nadja: Ja gerne, hat mir super viel Spaß gemacht. Vielen Dank, ist ja ein Herzensthema! Julia: Eben! Mir hat’s auch riesig viel Spaß gemacht. Ich habe wieder irrsinnig viel gelernt. Also weil grad das Thema ist so komplex und eben wenn man sich 5 Jahre mit nichts anderem beschäftigt, das ist einfach ein unglaublicher Wissensschatz, den du da angehäuft hast und der jetzt, nachdem du es geschafft hast, das in so einem tollen wirklich unglaublich gut gelungenen Buch niederzuschreiben, jetzt auch so vielen anderen Menschen damit helfen kannst, das zugänglich machen kannst und das ist wirklich unglaublich viel wert. Und danke dafür, dass du dir diese Zeit genommen hast, weil Buch schreiben ist Schweiß und Tränen und Blut und viel, viel, viel, viel Arbeit! Also wirklich toll, super gelungen und ich kann es nur jedem ans Herz legen und selbst wenn man jetzt nicht unbedingt selbst mit einer Allergie zu kämpfen hat, ist es trotzdem unbedingt ein lesenswertes Buch, weil man lernt sehr sehr viel andere Dinge und irgendwie einbauen kann man die immer und man kann auch davon profitieren, selbst wenn man jetzt nicht akut zumindest glaubt, keine Allergie zu haben oder keine Unverträglichkeit. Aber vieles kommt dann vielleicht erst auf. Nadja: Dankeschön, ja freut mich wenn es dir gefallen hat. Und ich freue mich natürlich über jedes Feedback und jede Bewertung die es dazu gibt. Kritisiert mich, haut mir rüber was ihr noch gelernt habt und was ihr wisst, weil dann wächst das Ganze. Das kann ja jederzeit verändert werden und ich finde das ist eine gute Sache. Julia: Genau, super. Ja dann, also vielen Dank und schönen Abend! Nadja: Danke, ebenfalls. Tschüß! Julia: Ciao. ##Bücher allergiefrei! Lebensmittelallergien und Unverträglichkeiten Verstehen. Lindern. Heilen. Webseiten Nadja Polzin - foodlinx Nadja Polzin - foodlinx.de | Paleo Low Carb - JULIAS BLOG | (auf Facebook folgen)

Marion G. Peters, MD. Professor, Department of Medicine, Chief of Hepatology Research, UCSF. Series: "UCSF Transplant Update" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 31722]

Marion G. Peters, MD. Professor, Department of Medicine, Chief of Hepatology Research, UCSF. Series: "UCSF Transplant Update" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 31722]

Dr James Galloway and Dr Justin Mason, Imperial College London, UK discuss a paper published in the Journal by John Stone et al. who looked at patients with IgG4 related disease treated with rituximab, to determine if there were potential markers to predict relapse in patients after treatment. They discuss the potential implications for future treatment, drawbacks of the study and possible future research directions for the disease.

Dr James Galloway and Dr Justin Mason, Imperial College London, UK discuss a paper published in the Journal by John Stone et al. who looked at patients with IgG4 related disease treated with rituximab, to determine if there were potential markers to predict relapse in patients after treatment. They discuss the potential implications for future treatment, drawbacks of the study and possible future research directions for the disease.

Dr James Galloway and Dr Justin Mason, Imperial College London, UK discuss a paper published in the Journal by John Stone et al. who looked at patients with IgG4 related disease treated with rituximab, to determine if there were potential markers to predict relapse in patients after treatment. They discuss the potential implications for future treatment, drawbacks of the study and possible future research directions for the disease.

A hepatologist and academic, a wife and a mother of two, Dr Ellie Barnes delighted researchers at the Wellcome Trust Centre for Human Genetics’ Women in Science talk, held on Wednesday the 20th of November 2013 Her presentation entitled: Women in Science – the joys and the juggles, highlighted the ups and downs of balancing a career in science, particularly as a working mother. Currently balancing three major projects: leading a £5 million collaboration called Stop HCV, trialling a powerful new Hepatitis C vaccine, and studying B cell immunology and IgG4 systemic disease, Ellie is now at a senior level in her career. But she admited that getting to this point hasn’t exactly been smooth sailing. Having her first child while studying her PhD and second just before receiving her intermediate MRC award, Ellie said it’s often hard to manage the demands of work and home, but being able to do what you love day in and day out makes it worth the struggle.

A hepatologist and academic, a wife and a mother of two, Dr Ellie Barnes delighted researchers at the Wellcome Trust Centre for Human Genetics’ Women in Science talk, held on Wednesday the 20th of November 2013 Her presentation entitled: Women in Science – the joys and the juggles, highlighted the ups and downs of balancing a career in science, particularly as a working mother. Currently balancing three major projects: leading a £5 million collaboration called Stop HCV, trialling a powerful new Hepatitis C vaccine, and studying B cell immunology and IgG4 systemic disease, Ellie is now at a senior level in her career. But she admited that getting to this point hasn’t exactly been smooth sailing. Having her first child while studying her PhD and second just before receiving her intermediate MRC award, Ellie said it’s often hard to manage the demands of work and home, but being able to do what you love day in and day out makes it worth the struggle.

The recent addition of immunoglobulin (Ig)G4-associated cholangitis (IAC), also called IgG4-related sclerosing cholangitis (IRSC), to the spectrum of chronic cholangiopathies has created the clinical need for reliable methods to discriminate between IAC and the more common cholestatic entities, primary (PSC) and secondary sclerosing cholangitis. The current American Association for the Study of Liver Diseases practice guidelines for PSC advise on the measurement of specific Ig (sIg)G4 in PSC patients, but interpretation of elevated sIgG4 levels remains unclear. We aimed to provide an algorithm to distinguish IAC from PSC using sIgG analyses. We measured total IgG and IgG subclasses in serum samples of IAC (n = 73) and PSC (n = 310) patients, as well as in serum samples of disease controls (primary biliary cirrhosis; n = 22). sIgG4 levels were elevated above the upper limit of normal (ULN = >1.4 g/L) in 45 PSC patients (15%; 95% confidence interval [CI]: 11-19). The highest specificity and positive predictive value (PPV; 100%) for IAC were reached when applying the 4× ULN (sIgG4 > 5.6 g/L) cutoff with a sensitivity of 42% (95% CI: 31-55). However, in patients with a sIgG4 between 1× and 2× ULN (n = 38/45), the PPV of sIgG4 for IAC was only 28%. In this subgroup, the sIgG4/sIgG1 ratio cutoff of 0.24 yielded a sensitivity of 80% (95% CI: 51-95), a specificity of 74% (95% CI: 57-86), a PPV of 55% (95% CI: 33-75), and a negative predictive value of 90% (95% CI: 73-97). Conclusion: Elevated sIgG4 (>1.4 g/L) occurred in 15% of patients with PSC. In patients with a sIgG4 >1.4 and