Antibody isotype
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3 episodes with igg4
2 episodes with igg4
2 episodes with igg4
2 episodes with igg4
2 episodes with igg4
2 episodes with igg4
3 episodes with igg4
2 episodes with igg4
2 episodes with igg4
America Out Loud PULSE with Dr. Peter McCullough and Malcolm Out Loud – How do you know that the mRNA is removed by sweating? Is it the spike protein or the mRNA and LNPs that exhaust the T-cells and make the body tolerate IgG4? I'm not downplaying the vaccines, but is the Covid virus causing some of the problems that we see today? The body's ability to fight off cancer in vaccinated individuals?
America Out Loud PULSE with Dr. Peter McCullough and Malcolm Out Loud – How do you know that the mRNA is removed by sweating? Is it the spike protein or the mRNA and LNPs that exhaust the T-cells and make the body tolerate IgG4? I'm not downplaying the vaccines, but is the Covid virus causing some of the problems that we see today? The body's ability to fight off cancer in vaccinated individuals?
Immunoglobulin G4-related disease (IgG4-RD) isn't always obvious; join our expert roundtable to learn when to suspect it and how to detect flares. Credit available for this activity expires: 8/12/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002730?ecd=bdc_podcast_libsyn_mscpedu
Radiation for skin cancer - with Dr. Jacob Scott! -Lipedema - not just for social media (?) - Inebilizumab for IgG4 disease -HTN and PWS -Learn more about radiation therapy and other non-surgical options for skin cancer treatment at The Dermatology Association of Radiation Therapy: https://dermassociationrt.org/Join Luke's CME experience on Jak inhibitors! rushu.gathered.com/invite/ELe31Enb69Learn more about the U of U Dermatology ECHO model!https://physicians.utah.edu/echo/dermatology-primarycare#:~:text=ECHO%20Model,being%20presented%20in%20the%20session.Want to donate to the cause? Do so here!Donate to the podcast: uofuhealth.org/dermasphereCheck out our video content on YouTube:www.youtube.com/@dermaspherepodcastand VuMedi!: www.vumedi.com/channel/dermasphere/The University of Utah's DermatologyECHO: physicians.utah.edu/echo/dermatology-primarycare - Connect with us!- Web: dermaspherepodcast.com/ - Twitter: @DermaspherePC- Instagram: dermaspherepodcast- Facebook: www.facebook.com/DermaspherePodcast/- Check out Luke and Michelle's other podcast,SkinCast! healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no significant conflicts of interest… BUT check out ourfriends at:- Kikoxp.com (a social platform for doctors to share knowledge)- www.levelex.com/games/top-derm (A free dermatology game to learnmore dermatology!
A neuroinflammatory disorder with the potential to affect virtually any organ in the body, IgG4-related disease is a challenge on many fronts. The latest Editors' Choice paper in the June 2025 issue takes on this systemic disease, presenting a treatment algorithm for its management. This episode, PN's podcast editor Dr. Amy Ross Russell speaks with author Dr. Claire Rice. Hear an overview on the disease background, the signs in presentation, what to look for in the histology, and steroid treatment strategy. Read the paper: IgG4-related disease in the nervous system Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production by Amy Ross Russell and Brian O'Toole. Editing by Brian O'Toole. Thank you for listening.
Many topics today! First: FDA tentatively approves Moderna's new mRNA shot for Covid. What? And also why? Bret has six main points, which include discussion of mucosal immunity, IgG4, auto-immunity, long-term consequences, statistical tricks, and homeopathy. Then: how do we know what is true, and how can we avoid jumping to conclusions when triggered by language or circumstances that seem familiar and frustrating?...As explored through the story of Algerian boxer Imane Khelif, who has a Disorder of Sexual Development, won Olympic gold for beating women, but is definitely male. Finally: brief discussions of Glenn Greenwald, and Richard Dawkins. No, Dawkins, religion is not a mental infection.*****Our sponsors:CrowdHealth: Pay for healthcare with crowdfunding instead of insurance. It's way better. Use code DarkHorse at http://JoinCrowdHealth.com to get 1st 3 months for $99/month.ARMRA Colostrum is an ancient bioactive whole food that can strengthen your immune system. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.Helix: Excellent, sleep-enhancing, American-made mattresses. Go to www.HelixSleep.com/DarkHorse for 20% Off sitewide.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:Moderna press release: https://investors.modernatx.com/news/news-details/2025/Moderna-Receives-U-S--FDA-Approval-for-COVID-19-Vaccine-mNEXSPIKE/default.aspxKennedy on FDA and Moderna shot: https://x.com/seckennedy/status/1930012848056365294Mary Talley Bowden MD on the shots: https://x.com/mdbreathe/status/1927899248575545501Heather on Imane Khelif: https://x.com/HeatherEHeying/status/1929920193771516423Greenwald on the situation: https://x.com/ggreenwald/status/1928440222771015912Dawkins on religion: https://x.com/richarddawkins/status/1930184916190257320Support the show
This episode's theme is new diseases, whether they are newly described, or old diseases back in a new form. We start off with IgG4-related disease, a chronic multisystem disorder that is still being understood. Then there is a genetics paper on repeat expansion disorders, a group of conditions often thought as disparate but with quite a few commonalities. Next along is a fascinating case following gastric sleeve bariatric surgery, highlighting the dangers of travelling for unsupervised surgeries, and raising the question, “Are you getting enough soil in your diet?” There's also a discussion of what else Hoover's sign might represent, and the evolution of immunoglobulin use. Closing the episode is a paper offering a masterclass on the assessment of best interests in prolonged disorder of consciousness. Read the issue: https://pn.bmj.com/content/25/3/199 Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening.
AiArthritis diseases can be difficult enough to manage—but what happens when the symptoms don't fit neatly into a diagnosis? In this episode, AiArthritis Health Education Manager Leila shares her perspective on the “mystery patient” experience, those living with serious, ongoing symptoms but still searching for answers. Leila revisits key conversations from past episodes and introduces new resources, including our updated Mystery Patient Guide and the AUTO + Inflammatory Arthritis = X or YZ Project, which explores lesser-known or overlapping conditions like IgG4-related disease (IgG4-RD). She also shares the powerful story of a real mystery patient navigating the challenges of being undiagnosed for years. If you or someone you love is living in diagnostic limbo, this episode offers validation, education, and practical tools to help guide your journey and highlights why improving awareness and research for this often-overlooked community is so essential. Donate to Support the Show: www.aiarthritis.org/donate Episode Highlights: Learn why some patients remain undiagnosed for years and what defines a “mystery patient.” Hear a real patient story that illustrates the challenges of navigating misdiagnosis. Understand how overlapping conditions like IgG4-RD complicate the diagnostic process. Discover key takeaways from the IgG4-RD Educational Summit, including treatment updates. Explore tools and resources available to support those still searching for answers. Links & Resources Mystery Patient Guide: www.aiarthritis.org/undiagnosed Volunteer with AiArthritis : https://bit.ly/AiArthritisVolunteerApp IgG4-RD Resource :https://igg4ward.org/education-and-resources Start Your Team for World AiArthritis Day: givebutter.com/aiarthritisday25 World AiArthritis Day Information: www.aiarthritis.org/aiarthritisday Follow AiArthritis on all social media platforms @IFAiArthritis Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE Connect with our Cohost: Leila P.L. Valete is the Health Education Manager at the International Foundation for AiArthritis. She is a person living with Lupus & Sjögren's. She is passionate about inclusion and diversity in health education and meeting individuals where they are at in order to learn in a way that resonates with them. Leila is on social media as @Lupus.Lifestyle.Lei sharing bits and pieces about her life with lupus and connecting with others. Connect with Leila: Tiktok: @Lupus.lifestyle.lei
Marlies Dekkers in gesprek met Jan Bonte over vaccinatieschade en meer. "Vaccins zijn een uitstekende medische techniek, maar je moet het niet in handen geven van de verkeerde mensen."--Steun DNW en word patroon op http://www.petjeaf.com/denieuwewereld.Liever direct overmaken? Maak dan uw gift over naar NL61 RABO 0357 5828 61 t.n.v. Stichting De Nieuwe Wereld. Crypto's doneren kan via https://commerce.coinbase.com/pay/79870e0f-f817-463e-bde7-a5a8cb08c09f-- Bronnen en links bij deze uitzending: - Het vorige gesprek tussen Marlies en Jan Bonte, over de oorsprong van corona: https://www.youtube.com/watch?v=OV3XC7GE6Uc- Marlies in gesprek met Arno Wellens: https://www.youtube.com/watch?v=GtKcx-ldQco- Marlies in gesprek met Hester Bais: https://www.youtube.com/watch?v=948rgaGD05I- 'De Hommel vertelt - De Wuhan Trilogie', theatercollege van Jan Bonte: https://vimeo.com/ondemand/dehommelvertelt- Spurious correlations: https://www.tylervigen.com/spurious-correlations- Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections: https://www.journalofinfection.com/article/S0163-4453(25)00067-2/fulltext- Expression of SARS-CoV-2 spike protein in cerebral Arteries: Implications for hemorrhagic stroke Post-mRNA vaccination: https://pubmed.ncbi.nlm.nih.gov/40184822/--00:00 Introductie00:50 Oorsprong van het coronavirus8:41 Van corona-angst naar Poetinangst13:48 "Mijn kinderen hebben hier geen toekomst meer"16:28 "Grootste medische schandaal van de eeuw"32:01 DNA in vaccins?39:09 Meer ontvankelijk voor virus door vaccin?51:25 Enkele casussen1:06:18 Kan er nu nog wat aan gedaan worden?1:15:00 Afronding--De Nieuwe Wereld TV is een platform dat mensen uit verschillende disciplines bij elkaar brengt om na te denken over grote veranderingen die op komst zijn door een combinatie van snelle technologische ontwikkelingen en globalisering. Het is een initiatief van filosoof Ad Verbrugge in samenwerking met anchors Jelle van Baardewijk en Marlies Dekkers. De Nieuwe Wereld TV wordt gemaakt in samenwerking met de Filosofische School Nederland. Onze website: https://denieuwewereld.tv/ DNW heeft ook een Substack. Meld je hier aan: https://denieuwewereld.substack.com/
In this episode, we dive into the complexities of IgG4-Related Disease (IgG4-RD), a mysterious and multi-organ condition that continues to challenge both patients and physicians. Back in January 2024, Dr. John Stone introduced us to the emerging landscape of treatments for IgG4-RD, and today, Dr. Matthew Baker joins us to provide an exciting update. With new therapies on the horizon, we explore the role of B and T cell pathogenesis, the limitations of traditional steroid treatments, and the off-label use of rituximab. We also take a closer look at the promising results from the “Mitigate Trial,” which offers hope for future strategies in managing this enigmatic disease. Join us as we discuss the evolving treatment landscape and what lies ahead for those affected by IgG4-RD.
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. The FDA is facing a potential "catastrophic collapse" due to massive layoffs that are endangering its user fee program, which provides nearly half of its yearly funding. More than half of the senior leadership at the agency has left, leading to a lack of communication, transparency, and human decency. The agency is at risk of losing its funding and ability to support its operations and employee salaries. In other news, Amgen has won an expansion for Uplizna as the first drug for IgG4-related disease, Lilly has made a pact with Sangamo worth a potential $1.4 billion, and Trilink offers custom guide RNAs for CRISPR workflows. The cell and gene therapy sector has seen a 30% investment surge despite market challenges.
America Out Loud PULSE with Malcolm Out Loud – My question is about gain of function research. Why is it still being done in America, and why hasn't anyone stopped this research from continuing? Is the damage caused by the covid vaccines irreversible? Has every vaccinated person destroyed their immune system because of the vaccine shifting the human body from producing just IgG1 and IgG3 to 20% IgG4 and is there anything that can be done to reverse it?
America Out Loud PULSE with Malcolm Out Loud – My question is about gain of function research. Why is it still being done in America, and why hasn't anyone stopped this research from continuing? Is the damage caused by the covid vaccines irreversible? Has every vaccinated person destroyed their immune system because of the vaccine shifting the human body from producing just IgG1 and IgG3 to 20% IgG4 and is there anything that can be done to reverse it?
Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.
In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center's long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Influenza weekly surveillance report: cliff notes (CDC FluView) US respiratory virus activity (CDC Respiratory Illnesses) Influenza vaccines protect against secondary infections in households (JAMA Network) Benefit of early oseltamivir therapy for influenza A (CID) RSV-Network (CDC Respiratory Syncytial virus Infection) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Maternal infection of SARS-CoV-2 during 1st and 2nd trimesters newborn telomere shortening (Journal of Translational Medicine) What is a B1 cell? (Wikipedia) Pre-COVID and post-COVID vaccination on long COVID (Journal of Infection) Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies after BNT162b2 Vaccination in Children (The Pediatric Infectious Disease Journal) Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine) Phase III trial results! Comparative efficacy and safety of COVID-19 vaccines (BMC Infectious Diseases) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID(Scientific Reports) Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine (BMC Infectious Diseases) Measurement of circulating viral antigens post-SARS-CoV-2 infection (CID) Letters read on TWiV 1172 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Send us a textPodcast episodes are fully available to paid subscribers on the M&M Substack and full video versions are free on YouTube. This episode will not be posted on YouTube due to the controversial nature of the content.About the guest: Jessica Rose, PhD is a computational biologist who has been studying and analyzing data from the Vaccine Adverse Event Responding System (VAERS) related to COVID. Episode summary: Nick and Dr. Rose discuss: Vaccine Adverse Event Responding System (VAERS); analysis of VAERS data for COVID; mRNA technology; spike protein persistence & lipid nanoparticles; common adverse events reported for the Pfizer & Moderna shots; myocarditis & menstrual irregularities; IgG4 antibodies, molecular mimicry & autoimmunity; and more.Related episodes:M&M #196: Vaccine Contamination & Fiat Science | Kevin McKernanM&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization of Science | Jay BhattacharyaSpecial offer: Use MINDMATTERSPECIAL2 for a free 1-year premium subscription to Consensus, an AI-powered research tool that helps you find the best science, faster. ($150 value, limited-time offer).*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. KetoCitra—Ketone body BHB with potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Consensus: AI-powered academic research tool. Find & understand the best science, faster. Free 1-year premium sub with code MINDMATTERSPECIAL (exp 12.10.24) Learn all the ways you can support my efforts...
Send us a textAbout the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project.Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vaccines; vaccine adverse events & IgG4 immune modulation; concerns with COVID PCR testing; origins of the SARS-CoV-2 virus; Fiat Science from the AIDS epidemic to today; how Big Pharma works with government regulators; decentralized medicine; and more.Related episodes:M&M #149: DNA & RNA Biology, mRNA Vaccines, Vax Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernanM&M #97: How Did the SARS-CoV-2 Virus Originate? | Alex WashburneSpecial offer: Use code MINDMATTERSPECIAL for a limited time to get a free 1-year premium subscription to Consensus, a new AI-powered research tool to help you find the best science, faster.*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. SiPhox Health—Affordable, at-home bloodwork. Comprehensive set of key health markers. Use code TRIKOMES for a 10% discount. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Consensus: AI-powered academic research tool. Find & understand the best science, faster. Free 1-year premium sub with code MINDMATTERSPECIAL (expires 12.10.24) Learn all the ways you can support my efforts...
America Out Loud PULSE with Dr. Peter McCullough and Malcolm – I find myself without a candidate -- with the looming possibility that our elections could be theater... I do get tight-chested and get irregular beating, but my ECGs and EKGs are fine. Should I worry?... How long does the spike protein from the vax last in the body?... The vaccine exhausts the T-cells and makes the body IGg4 tolerant, but is this true for everyone?
America Out Loud PULSE with Dr. Peter McCullough and Malcolm – I find myself without a candidate -- with the looming possibility that our elections could be theater... I do get tight-chested and get irregular beating, but my ECGs and EKGs are fine. Should I worry?... How long does the spike protein from the vax last in the body?... The vaccine exhausts the T-cells and makes the body IGg4 tolerant, but is this true for everyone?
Show Notes https://www.rushtoreason.com/show-notes/10-31-2024/
In this episode, Jonathan is joined by John H. Stone, Professor of Medicine at Harvard Medical School and The Edward A. Fox Chair in Medicine at Massachusetts General Hospital. Stone discusses his groundbreaking work in systemic vasculitis, including granulomatosis with polyangiitis and ANCA-associated vasculitis. He also shares insights into the emerging field of IgG4-related disease and the exciting possibility of the first approved therapy for this condition. Alongside, he delves into his efforts to minimise glucocorticoid toxicity and his work through the IgG4ward! Foundation. Timestamps: (00:30) – Introduction (04:00) – Stone's journey into rheumatology (07:28) – WEGET trial (10:30) – Developments in IgG4-related disease and the path to therapy approval (15:52) – Key advancements in the treatment of granulomatosis with polyangiitis (18:04) – Glucocorticoid toxicity and the Glucocorticoid Toxicity Index (GTI) (20:34) – The IgG4ward! Foundation (23:48) – Two Pearls and a Myth (26:45) – Stone's three wishes for rheumatology
This week Dr Thomas Bond covers IgG4 related disease. A tricky, rare condition, which can often mimic other problems, IgG4 RD is difficult to diagnose if the differential doesn't cross your mind. Get the highlights in the episode of MEMCast!
Dr. Stacey Clardy discusses how to test for IgG4-related disease and how to interpret MIR imaging findings. Show reference: https://ard.bmj.com/content/74/1/14a
Dr. Stacey Clardy discusses the importance of iron and ferritin in neurology in this lab minute. Show reference: https://ard.bmj.com/content/74/1/14a
Research is piling up to reveal that the mRNA vaccines increasingly weaken the immune system with each booster. Jefferey dives deeper into what “HighWire” guests Bret Weinstein, PhD and William Makis, MD both detail – multiple vaccinations causing a class switch in antibody production to an overproduction of IgG4, the antibody responsible for dampening immune response, and underproduction of IgG1 and IgG3, the antibodies responsible for cancer surveillance.
Many autoimmune neuromuscular disorders are reversible with prompt diagnosis and early treatment. Understanding the potential utility and limitations of antibody testing in each clinical setting is critical for practicing neurologists. In this episode, Teshamae Monteith, MD, FAAN speaks with Divyanshu Dubey, MD, FAAN, author of the article “Autoimmune Neuromuscular Disorders Associated With Neural Antibodies,” in the Continuum® August 2024 Autoimmune Neurology issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. Dubey is an associate professor in the departments of neurology and laboratory medicine and pathology at the Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Autoimmune Neuromuscular Disorders Associated With Neural Antibodies Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Guest: @Div_Dubey Transcript Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. Today, I'm interviewing Dr Divyanshu Dubey about his article on autoimmune neuromuscular disorders associated with neural autoantibodies, which is part of the August 2024 Continuum issue on autoimmune neurology. Welcome to the podcast. How are you? Dr Dubey: Hi, Dr Monteith. Thank you for inviting me to be a part of this podcast. I'm doing well. Dr Monteith: Well, why don't you introduce yourself to the audience? And, call me Tesha. Dr Dubey: I'm Divyanshu Dubey (please, call me Div). I'm one of the autoimmune neurology consultants here at Mayo Clinic Rochester. I'm an Associate Professor of neurology, as well as lab medicine and pathology. My responsibilities here are split - partly seeing patients (primarily patients with autoimmune disorders, including neuromuscular disorders), and then 50% of my time (or, actually, more than 50%), I spend in the lab, either doing research on these autoimmune disorders or reporting antibodies in a clinical setting for various antibody panels which Mayo's neuroimmunology lab offers. Dr Monteith: That's a nice overlap of subspecialty area. How did you get into this work? Dr Dubey: I think a lot of it was, sort of, by chance. Meeting the right people at the right time was the main, sort of, motivation for me. Initially, I trained in India for my medical school and didn't really got much exposed to autoimmune neurology in India. I think our primary concern in my training was sort of treating TB meningitis and cerebral malaria - that was my exposure to neurology, including stroke and some epilepsy cases. As a part of application for USMLEs and coming here to residency, I did some externships, and one of the externships was at Memorial Sloan Kettering Cancer Center, and that's when I worked a few weeks with Dr Posner and got introduced to the idea of paraneoplastic neurological syndrome working with him. And that sort of started - I wouldn't call it vicious cycle - but my interest in the area of autoimmune neurology and paraneoplastic neurological disorders, which subsequently was refined further through residency and fellowships. Dr Monteith: That's interesting. I actually rotated through - I did a externship also at Sloan Kettering, and I had a clinic with Dr Posner. And I thought, at the time, he was such a rock star, and, like, I took a picture with him, and I think he thought it was insane. And I didn't go into autoimmune neurology. So, you know, interesting pathways, right? Dr Dubey: Yes. And I think he's inspired many, many people, and sort of trained a lot of them as well. Dr Monteith: So, why don't you tell us what you set out to do when writing this article? Dr Dubey: So, I think, given my background and training in various subspecialties in neurology, I was, sort of, formally did fellowships in autoimmune neurology, as well as neuromuscular medicine. One of the areas in these areas that I focus on is in my clinical practice, as well as in my sort of lab work, is autoimmune muscular disorders - and that to, specifically, autoantibodies and their clinical utility for autoimmune muscular disorders. So, that's what I wanted to focus on in an article. When I was invited to write an article on autoimmune muscular conditions in general, I thought it was very difficult to pack it all in one chapter or one article, so I narrowed my focus (or tilted my focus) towards antibody-positive disorders and trying to understand how we as neurologists can firstly sort of identify these conditions (which may end up being antibody-positive) – and then, on the other hand, once we get these antibody results, how we can find the utility in them or find them useful in taking care of our patients. At the same time, I also wanted to kind of highlight that these antibodies are not perfect, they do have certain limitations – so, that's another thing I sort of highlighted in the article. Dr Monteith: So, why don't we just start with a very broad question - what do you believe the role of autoantibodies is in the workup of neuropathies and then neuromuscular disorders? Obviously, when we think of myasthenia gravis, but there are some presentations that you may not necessarily think to first order autoantibody tests. So, what is the role, and where does it fit in the paradigm? Dr Dubey: I think it's extremely crucial, and it's evolving as time goes on, and it's becoming more and more clinically relevant. Let's say three, four decades ago, the number of biomarkers which were available were very limited and only a handful - and there has been a significant increase in these biomarkers with growing utilization of newer techniques for discovery of antibodies, and more and more people jumping into this field trying to not only discover, but try and understand and validate these biomarkers (what they truly, clinically mean). These antibodies, like you pointed out, ones for myasthenia (such as acetylcholine receptor-binding antibodies, or MuSK antibodies), they can be extremely helpful in clinical diagnosis of these patients. We all know the importance of EMG in managing our patients with neuromuscular disorders. But, oftentimes, EMG nerve conduction studies are often not available at every center. In those scenarios, if you have antibodies with very high clinical specificity, and you're seeing a patient on examination whom you're seeing ptosis (fatigable ptosis), double vision, you're suspecting myasthenia, you send antibodies, and they come back positive. It brings you closer to the answer that may, in turn, require you to refer to a patient to a place where you can get high-quality EMGs or high-quality care. In addition to getting to the diagnosis, it also, sometimes, leads you in directions to search for what is the trigger. A good example is all these paraneoplastic neurological syndromes (which we started our conversation with), where once you find a biomarker (such as anti-Hu antibodies or CRMP5 antibodies) in a patient with paraneoplastic neuropathies, it can direct the search for cancer. These are the patients where, specifically, these two antibodies, small-cell lung cancer is an important cancer to rule out - they require CT scans, and if those are negative, consider doing PET scan – so, we can remove the inciting factor in these cases. And then, lastly, it can guide treatment. Depending upon subtypes of antibodies or particular antibodies, it can give us some idea what is going to be the most effective treatment for these patients. Dr Monteith: I think paraneoplastic syndromes are a very good example of how autoantibodies can help guide treatment. But, what other examples can you provide for us? Dr Dubey: Yeah, so I think one of the relatively recent antibody tests which our lab started offering is biomarkers of autoimmune neuropathies - these are neurofascin and contactin, and those are great examples which can target or guide your treatment. I personally, in the past, have had many CIDP patients before we were offering these testings, where we used to kind of start these patients on IVIG. They had the typical electrodiagnostic features, which would qualify them for CIDP. They did not show any response. In many of these cases, we tried to do sort of clinical testing or sort of research-based testing for neurofascin and contactin back in the day, but we didn't have this resource where we can sort of send the blood, hopefully, and within a week, get an answer, whether these patients have autoimmune neuropathy or not. Having this resource now, in some of these cases, even before starting them on IVIG, knowing that test result can guide treatments, such as considering plasma exchange up front as a first-line therapy, followed by rituximab or B-cell depleting therapies, which have been shown to be extremely beneficial in these conditions. And it is not just limited to neurofascin or contactin (which are predominantly IgG4-mediated condition), but the same concept applies to other IgG4-mediated diseases, such as MuSK myasthenia, where having an antibody result can guide your treatment towards B-cell depleting therapies instead of sort of trying the typical regimen that you try for other myasthenia gravis patients. Dr Monteith: And you mentioned where I was reading that, sometimes, nerve conduction studies and EMG can be useful to then narrow the autoantibody profiles. Oftentimes, in the inpatient service, we order the autoantibodies much faster, because it's sometimes harder to access EMG nerve conduction studies - but talk about that narrowing process. Dr Dubey: Yeah. And it goes back to the point you just made where we end up sending, sort of, sometimes (and I'm guilty of this as well), where we just send antibodies incessantly, even knowing that this particular patient is not necessarily likely to be an autoimmune neurological disorder, and that can be a challenge, even if the false-positive rate for a particular test is, let's say 1% - if you send enough panels, you will get that false-positive result for a particular patient. And that can have significant effects on the patient - not only unnecessary testing or imaging (depending on what type of antibody it is), but also exposure to various immunotherapies or immunosuppressive therapies. It's important to recognize red flags – and that's one of the things I've focused on in this article, is talking about clinical, as well as electrodiagnostic, factors, which make us think that this might be an autoimmune condition, and then, subsequently, we should consider autoantibody testing. Otherwise, we can be in a situation - that 1% situation - where we may be sort of dealing with a false-positive result, rather than a true-positive result. In terms of EMGs, I think I find them extremely useful, specifically for neuropathies, distinguishing between demyelinating versus exonal, and then catering our antibody-ordering practices toward specific groups of antibodies which are associated with demyelinating neuropathies (if that's what the electrophysiology showed) versus if it's an exonal pathology (considering a different subset of antibodies) - and that's going to be extremely important. Dr Monteith: You're already getting to my next question, which is what are some of the limitations of autoantibody testing? You mentioned the false-positivity rate - what other limitations are there? Dr Dubey: So, I think the limitations are both for seropositive, as well as seronegative, patients. As a neurologist, when we see patients and send panels, we can be in a challenging situation in both of those scenarios. Firstly, thinking about seropositives - despite the growing literature about neurology and antibodies, we have to be aware, at least to some extent, about what methodologies are being utilized for these antibody tests. And what I mean by that is knowing when you're sending a sample to a particular lab, the methodology that they're utilizing - is that the most sensitive, specific way to test for certain antibodies? We've learned about this through some of the literature published regarding MOG and aquaporin-4, which has demonstrated that these antibodies, which we suspect are cell surface antibodies, not only generate false-positive, but also false-negative results if they are tested by Western blots or ELISAs. Similar can be applied to some of the cell surface antibodies we are investigating on the autoimmune neuromuscular side (we have some sort of unpublished data regarding that for neurofascin-155). Secondly, it's also kind of critical when you're getting these reports to kind of have a look at what type of secondary antibodies are being utilized, an example being we talked about neurofascin-155, and I mentioned these are IgG4-predominant diseases, so testing for neurofascin IgG4 and knowing that particular patient is positive IgG4 rather than neurofascin pan-IgG. That's an important discrimination, and important information for you to know, because we have seen, at least in my clinical practice, that patients who are positive for neurofascin IgG4 follow the typical story of autoimmune neuropathies - the ones who are not (who are just neurofascin-155 IgG-positive), oftentimes can have wide-ranging phenotypes. The same applies to neurofascin-155 IgMs. And then (not for all antibodies, but for some antibodies), titers are important. A good example of that is a3 ganglionic receptor antibodies, which we utilize for when we're taking care of patients who have autoimmune dysautonomia - and in these cases, if the titers of the antibodies are below .2 nmol/L, usually, those don't have a high specificity for AAG diagnosis. So, I get referred a lot of patients with very low titers of a3 ganglionic receptor antibodies, where the clinical picture does not at all look like autoimmune autonomic ganglionopathy. So, that's another thing to potentially keep in mind. And then, on the seronegative front, it's important to recognize that we are still sort of seeing the tip of the iceberg as far as these antibodies or biomarkers are concerned, specifically for certain phenotypes, such as CIDP. If you look at the literature, depending upon what demographics we're looking at or sort of racial profiles we're looking at, the frequency of these autoimmune neuropathy biomarkers range from 5% to 20%, with much higher frequency in Asian patients - so, a good chunk of these diseases are still seronegative. In the scenario where you have a very high suspicion for an autoimmune neuromuscular disorder (specifically, we'll talk about neuropathies, because that's why we utilize tissue immunofluorescence staining on neural tissues), I recommend people to potentially touch base with that tertiary care lab or that referral lab to see if they have come across some research-based antibodies which are not clinically validated, which can give you some idea, some additional supportive idea, that what you're dealing with is an autoimmune neuromuscular disorder. So, we have to keep the limitations of some of these antibody panels and antibody tests in mind for both positive, as well as negative, results. Dr Monteith: So, you've already given us a lot of good stuff, um, about titer seronegativity and false-positive rates. And, you know, also looking at the clinical picture when ordering these tests, utilizing EMG nerve conduction studies, give us a major key point that we can't not get when reading your article. Dr Dubey: I think the major key point is we are neurologists first and serologists later. Most of these patients, we have to kind of evaluate them clinically and convince ourselves at least partly that this might be an autoimmune neuromuscular disorder before sending off these panels. Also, I find it useful to narrow down the phenotype, let's say, in a particular neuropathy or a muscle disease or a hyperexcitability syndrome. So, I have a core group of antigens, autoantigens, or autoantibodies, which I'm expecting and making myself aware of - things beyond that will raise my antenna - potentially, is this truly relevant? Could this be potentially false-positive? So, clinical characterization up front, phenotypic characterization upfront, and then utilizing those antibody results to support our clinical decision-making and therapeutic decision-making is what I've tried to express in this article. Dr Monteith: And what is something that you wish you knew much earlier in your career? Dr Dubey: It's a very challenging field, and it's a rapidly evolving field where we learn many things nearly every year, and, sometimes, we learn things that were previously said were incorrect, and we need to kind of work on them. A good example of that is initial reports of voltage-gated potassium-channel antibodies. So, back in the day when I was actually in my medical school and (subsequently) in my residency, voltage-gated potassium-channel antibodies were closely associated with autoimmune neuromyotonia, or autoimmune peripheral hyperexcitability syndromes. Now, over time, we've recognized that only the patients who are positive for LGI1 or CASPR2 are the ones who truly have autoimmune neuromuscular disorders or even CNS disorders. The voltage-gated potassium-channel antibody by itself, without LGI1 or CASPR2, truly doesn't have a very high specificity for neurological autoimmunity. So, that's one example of how even things which were published were considered critical thinking or critical knowledge in our field of autoimmune neuromuscular disorders has evolved and has sort of changed over time. And, again, the new antibodies are another area where nearly every year, something new pops up - not everything truly stands a test of time, but this keeps us on our toes. Dr Monteith: And what's something that a patient taught you? Dr Dubey: I think one of the things with every patient interaction I recognize is being an autoimmune neurologist, we tend to focus a lot on firstly, diagnosis, and secondly, immunotherapy - but what I've realized is symptomatic and functional care beyond immunotherapy in these patients who have autoimmune neurological disorders is as important, if not more important. That includes care of patients, involving our colleagues from physical medicine and rehab in terms of exercise regimen for these patients as we do immunotherapies, potentially getting a plan for management of associated pain, and many other factors and many other symptoms that these patients have to deal with secondary to these autoimmune neurological conditions. Dr Monteith: I think that's really well said, because we get excited about getting the diagnosis and then getting the treatment, but that long-term trajectory and quality of life is really what patients are seeking. Dr Dubey: Yeah, and as you pointed out, most of the time, especially when we are in inpatient service, or even when we're seeing the patients upfront outpatient, we are seeing them, sometimes, in their acute phase or at their disease not there. What we also have to realize is, what are the implications of these autoimmune neurological conditions in the long term or five years down the line? And that's one of the questions patients often ask me and how this can impact them even when the active immune phase has subsided - and that's something we are actively trying to learn about. Dr Monteith: So, tell me something you're really excited about in your field. Dr Dubey: I think, firstly (which is pretty much the topic of my entire article), is novel antibodies and new biomarker discoveries. That's very exciting - we are actively, ourselves, involved in the space. The second thing is better mechanistic understanding of how these antibodies cause diseases, so we can not only understand diseases, we can also try and understand how to target and treat these diseases - this is being actively done for various disorders. One of the disorders which continue to remain a challenge are T-cell mediated diseases, where these antibodies are just red flags or biomarkers are not causing the disease, but it's potentially the T-cells possibly attacking the same antigen which are causing disease process, and those are often the more refractory and harder-to-treat conditions. I'm hoping that with some of the work done in other fields (such as rheumatology or endocrinology for type one diabetes), we're able to learn and apply the same in the field of autoimmune neurology and autoimmune neuromuscular medicine. And then, the final frontier is developing therapies which are antigen specific, where you have discovered that somebody has a particular antibody, and if that antibody is pathogenic, can I just deplete that antibody, not necessarily pan-depleting the immune system. And there is some translational data, there's some animal model data in that area, which I find very exciting, will be extremely helpful for many of my patients. Dr Monteith: So, very personalized targeted therapies? Dr Dubey: Correct. Without having all the side effects we all have to kind of take care of in our patients when we start them on, let's say, cyclophosphamide, or some of these really, really, significantly suppressive immunosuppressive medications. Dr Monteith: Well, thank you so much. I learned a lot from reading your article to prepare for this interview, but also just from talking to you. And it's clear that you're very passionate about what you do and very knowledgeable as well, so, thank you so much. Dr Dubey: Thank you so much. Thank you for inviting me to do this. And thank you for inviting me to contribute the article. Dr Monteith: Today, I've been interviewing Dr Divyanshu Dubey, whose article on autoimmune neuromuscular disorders associated with neural autoantibodies appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information, important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.
Send us a Text Message.In this FRIDAY 5 episode of “The Autoimmune RESET,” VJ explores the essential markers that every comprehensive food reactivity test should include. Join your host, VJ Hamilton, as we break down the roles of IgG, IgG4, IgA, IgE, and Complement in uncovering hidden food sensitivities. Whether you're dealing with unexplained symptoms, managing an autoimmune condition, or simply curious about how food affects your health, these five markers provide crucial insights into your body's responses. Learn how understanding these markers can help tailor your diet, reduce inflammation, and improve your well-being. Tune in to discover how a deeper look at food sensitivities can transform your health journey.Have questions or comments? Connect with us on social media or visit our website at www.theautoimmunitynutritionist.com for more resources and information.You can learn more about food intolerances, sensitivities and allergies in this article. And if you would like to learn more about the P88 antigen reactivity screen, you can find out more here. Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.
Nurses Out Loud with Jodi O'Malley MSN, RN – I debunk myths around 'hybrid' immunity and vaccine-induced IgG4 responses. The classification of the COVID-19 vaccine sparks debate, with experts challenging its efficacy. I explore "hybrid" immunity, the controversial term in immunology, and the shift towards IgG4 antibody production, questioning the long-term protection offered by mRNA vaccines against COVID-19.
Nurses Out Loud with Jodi O'Malley MSN, RN – I debunk myths around 'hybrid' immunity and vaccine-induced IgG4 responses. The classification of the COVID-19 vaccine sparks debate, with experts challenging its efficacy. I explore "hybrid" immunity, the controversial term in immunology, and the shift towards IgG4 antibody production, questioning the long-term protection offered by mRNA vaccines against COVID-19.
This week we take you through a disease that can truly affect just about every organ system - IgG4 Related Disease. We will walk you through the presentation, work up, and approach to treatment Support the show
CardioNerds nerd out with Drs. Karishma Rahman (Mount Siani Vascular Medicine fellow), Shu Min Lao (Mount Sinai Rheumatology fellow), and Constantine Troupes (Mount Sinai Vascular Surgery fellow). They discuss the following case: A 20-year-old woman with a history of hypertension (HTN), initially thought to be secondary to a mid-aortic syndrome that resolved after aortic stenting, presents with a re-occurrence of HTN. The case will go through the differential diagnosis of early onset HTN focusing on structural etiologies of HTN, including mid-aortic syndrome and aortitis. We will also discuss the multi-modality imaging used for diagnosis and surveillance, indications and types of procedural intervention, and how to diagnose and treat an underlying inflammatory disorder leading to aortitis. The expert commentary was provided by Dr. Daniella Kadian-Dodov, Associate Professor of Medicine and Vascular Medicine specialist at the Icahn School of Medicine at Mount Sinai. Audo editing was performed by Dr. Chelsea Amo-Tweneboah, CardioNerds Academy Intern and medicine resident at Stony Brook University Hospital. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - Hypertension With a Twist Pearls - Hypertension With a Twist Early onset hypertension (HTN) and lower extremity claudication should raise suspicion for aortic stenosis (including mid-aortic syndrome). Initial evaluation should include arterial duplex ultrasound and cross-sectional imaging such as CT or MR angiogram of the chest, abdomen, and pelvis to assess for arterial stenosis involving the aorta and/or branching vessels. Mid-aortic syndrome can have multiple underlying etiologies. Concentric aortic wall thickening should raise suspicion for an underlying inflammatory disorder. Initial evaluation should include inflammatory markers such as ESR, CRP, and IL-6, but normal values do not exclude underlying aortitis. While Takayasu arteritis is the most common inflammatory disorder associated with mid-aortic syndrome, IgG4-RD should also be a part of the differential diagnosis. IgG subclass panel can detect IgG4-RD with elevated serum IgG4 levels, but some cases can require pathology for diagnosis. Catheter based intervention is a safe and effective treatment of aortic stenosis for both primary aortic stenosis and post-procedural re-stenosis. Multi-modality imaging, including cross-sectional imaging and duplex ultrasound, plays a central role for the diagnosis, management, and post-procedural surveillance of aortic disease. A multi-disciplinary team (as exemplified by the participants of this podcast!) is essential for the management of complex aortopathy cases to optimize clinical outcomes. Show Notes - Hypertension With a Twist 1. Early onset HTN can have multiple etiologies – aortic stenosis (including but not limited to secondary to congenital aortic coarctation and mid–aortic syndrome, as well as in stent re-stenosis if there is a history of aortic stenting), thrombosis, infection, inflammatory/autoimmune disorders, renovascular disease, polycystic kidney disease, and endocrine disorders. 2. Mid-aortic syndrome is characterized by segmental or diffuse narrowing of the abdominal and/or distal descending aorta with involvement of the branches of the proximal abdominal aorta (renal artery, celiac artery, superior mesenteric artery) and represents approximately 0.5 to 2% of all cases of aortic narrowing. Underlying etiologies include genetic syndromes, inflammatory, non-inflammatory, and idiopathic. It is important to have a high suspicion of underlying inflammatory disorders if cross-sectional i...
Join us this week for an in-depth discussion on IgG4-Related Disease with one of the premiere researchers in the field, Dr. John Stone. On this episode, Dr. Stone reviews the disease clinical presentation as well as its symptoms, how to make the diagnosis, treatment options, the role of IgG4 and what happens inside the body. Later, we discuss Dr. Stone's research along with his personal journey in the field.
Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours (12/13/23). As always, take the information discussed in the video below and research it for yourself, and come to your own conclusions. Anyone telling you what the truth is, or claiming they have the answer, is likely leading you astray, for one reason or another. Stay Vigilant. !function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/u2q643"+(arguments[1].video?'.'+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble"); Rumble("play", {"video":"v3yiqkb","div":"rumble_v3yiqkb"}); Video Source Links (In Chronological Order): Japan Approves World's First 'Self-Amplifying' mRNA COVID-19 Vaccine Without Published Efficacy Or Safety Data | ZeroHedge Self-Spreading Vaccines, Self-Amplifying mRNA Vaccines & COVID Vaccine Menstrual Disruption (11) Igor Chudov
God knows everything whispered in secret, and one day those things will be shouted from the rooftops. The people who run Biden, Tony Fauci being one of them, were whispering in the dark about the deaths and injuries from the mRNA injections. They knew. It's obvious how these injections were designed, that they would kill people. God knows their motives and 17 million people are most likely dead and will keep dying from these injections. We examine the state of things as we look at Britain, where a politician presents his concerns on the increased deaths following the pandemic to a 98% empty House of Commons. And in New Zealand, Liz Gunn spoke with a whistleblower about the deaths they are seeing as a consequence of the injections and how those in charge also knew about the adverse effects. What does God's Word say? Exodus 20:13“You shall not murder.”Galatians 6:7 Do not be deceived: God is not mocked, for whatever one sows, that will he also reap.Luke 12:3 3 What you have said in the dark will be heard in the daylight, and what you have whispered in the ear in the inner rooms will be proclaimed from the roofs.Which ones describes Fauci? The War Within; Flesh Versus SpiritEpisode 1,179 Links:Step Right Up And Spend $10,000 To Get Your Picture Taken With Prolific Liar Anthony FauciMichigan judge denies drug manufacturer's immunity in case of contaminated COVID-19 medicationA mass iatrogenic event that killed 17 million (0.213%) of world population so far. That's the conclusion of a September 2023 study of 17 countries that covered 10% of world population. The average global death rate is about 0.8% per annum (about 67 million), so the iatrogenic event corresponds to about 25% of of the annual global death rate. Andrew Bridgen, @ABridgen MP of North West Leicestershire, is so far the only western hemisphere politician to debate this topic in a public setting, today (!) in the UK House of Commons, with an empty row of seats. The good news: global birth rate still hovers around 1.2% per annum, so we're still producing about 30 million net lives per year. Not so good news: the fertility rate is dropping perpendicularly, due to the same iatrogenic factor.Andrew Bridgen's opening statement to an empty House of CommonsNew @FDA pre-print study: Active surveillance system finds elevated risk of seizures in toddlers and myocarditis in teenagers associated with covid mRNA vaccination.More proof the mRNAs rewire the immune system with unknown long-term effects; The biggest study yet on post-jab IgG4 "class switching" just came out. You will be shocked - SHOCKED - to hear American researchers had nothing to do with it.EXCLUSIVE: American Academy of Pediatrics Named In Bombshell Detransitioner LawsuitYoung girl was "unfortunate victim of a collection of actors who prioritized politics and ideology over children's safety," lawsuit states45 Predators caught in sting operation targeting children including one who was a cannibal. These Predators knowingly have Sexually Transmitted Disease. Parents please keep a close eye on your children4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. American Financing https://americanfinancing.net Visit to see what American Financing can do for you or call 866-887-2275 BiOptimizers https://bioptimizers.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. Call 866-779-RISK or visit KnowYourRiskRadio.com Patriot Mobile https://patriotmobile.com/herman Get free activation today with offer code HERMAN. Visit or call 878-PATRIOT. SOTA Weight Loss https://sotaweightloss.com SOTA Weight Loss is, say it with me now, STATE OF THE ART! Sound of Freedom https://angel.com/freedom Join the two million and see Sound of Freedom in theaters July 4th. GreenHaven Interactive https://greenhaveninteractive.com Digital Marketing including search engine optimization and website design.
The Health Advocates are joined by Nika Beamon who lives with IgG4-related disease (IgG-RD), a group of fibroinflammatory conditions that can impact various tissues, often leading to tumor-like growth or organ dysfunction. Nika shares her 17-year journey to an IgG4-RD diagnosis, including how she advocated for herself. She offers valuable tips for fellow chronic illness patients, highlighting the unique considerations people with autoimmune diseases have in everyday life. “So there's so many things that do alter your life. But at the end of the day, you got one life, so you got to live it, and so I just choose to live it regardless of the fact that this is how it's built,” says Nika. Among the highlights in this episode:00:50: Nika gives an in-depth account of her health struggles, which began in college. She discusses her IgG4 symptoms like constant fatigue, joint pain, and spontaneous fevers, which baffled doctors for years 04:25: Nika emphasizes the importance of self-advocacy and the need for patients to have all their medical records organized 05:20: After years of suffering, a top rheumatologist identifies Nika's condition, marking a significant turning point in her journey 05:35: Zoe Rothblatt, Associate Director of Community Outreach at GHLF, asks about Nika's reaction to finally receiving a diagnosis, underscoring the emotional impact of living undiagnosed for such a long period 07:46: Nika delves into her decision to write about her health journey and shares her personal experience of opening up to coworkers, revealing the challenges of living with a hidden illness 09:14: Nika discusses the complexities of diagnosing autoimmune diseases and the significance of patients being proactive, keeping detailed records, and ensuring doctors are listening to their concerns 13:01: Zoe emphasizes the challenges of managing a chronic illness, including the constant advocacy required, the need for continuous learning, and the difficulties in communicating with doctors 14:00: Nika discusses her experiences during the pandemic, especially the disparity between how she and others perceived the impact of illnesses like COVID 18:34: Nika emphasizes the importance of advocacy, surrounding oneself with a supportive community, and recognizing the disease as just a part of oneself 20:02: What our hosts learned from this episode Contact Our Hosts Steven Newmark, Director of Policy at GHLF: snewmark@ghlf.org Zoe Rothblatt, Associate Director, Community Outreach at GHLF: zrothblatt@ghlf.org We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Catch up on all our episodes on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.
The actions of local, state and federal government have killed many, and their culling may be the only thing that saves us; I discuss the first steps toward an attack on homeschooling; and I read from an article about IgG4 and what is happening and what will continue to happen. IgG4 article: https://veryvirology.substack.com/p/igg4-antibody-class-switch-end-of?nthPub=91
Episode 2066 - IgG4 immune antibodies are a mess right now. Introducing the new Healthmasters.com web site. A pound of prevention is worth a 1000 pounds of cure. Another crocodile story. Aldi leading the cashless movement? Bill Barr downgrades the first amendment? Plus much much more.. More of a fireside chat today.
Today, I am blessed to have here with me, Spencer Feldman. He founded Remedylink, where he has been formulating and manufacturing detoxification products for doctors and their patients. He was raised in New York where he spent most of his life before deciding the Pacific Northwest was where he belonged. Spencer can do what he loves daily by creating products that support natural detoxification, thanks to his training in holistic health, chelation therapy, and detoxification. Spencer has shared his love of health for over 20 years through his longest-running suppository company in the country, with goods that reflect proper workmanship and a commitment to quality. In this episode, Spencer discusses the importance of a balanced diet and its impact on microbiome health. The best way to improve our overall health is by detoxification. Spencer reveals the effective and convenient alternatives for detox. Tune in as we chat about long-term carnivore or high-fat diets, lysosomes' role, cyclodextrins and probiotics, and detoxification in maintaining overall health and promoting graceful aging. Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [06:16] Histamine Receptors and Allergies: A New Perspective on Health Disorders Allergic reactions can be immediate or delayed. The latter, often called intolerances, can occur hours after exposure to an allergen and can be harder to identify due to this delay. Histamine receptors are found throughout the body, not only in typical locations like the skin, sinuses, and lungs. Therefore, allergic reactions can affect various bodily systems. Health issues like interstitial cystitis, plaque in the arteries, and neurological conditions may have allergic components, meaning they may be triggered or worsened by allergies or intolerances. It's crucial to identify and minimize exposure to allergens, which can come from various sources, such as food, to mitigate these adverse health effects. This can be done through allergy and intolerance tests. Understanding the broader impact of allergies can lead to better diagnoses and treatments for various health conditions that might have been previously unexplained. [15:18] How Can You Manage Histamine Levels in Leftover Food? Check this out! Histamine, produced by bacteria, can accumulate in leftover food and may cause unpleasant reactions when consumed. This accumulation begins immediately after cooking and cannot be reversed by reheating. Refrigeration slows down histamine production by reducing bacterial activity. However, leftovers should be refrigerated immediately after cooking to limit histamine buildup effectively. Leftovers should be spread out rather than lumped in the fridge to speed up cooling and slow histamine buildup. This increases the surface area exposed to the cold temperature, helping the food cool down faster. Due to the potential histamine buildup in stored food, sensitive or reactive people may need to avoid leftovers until their condition is controlled. [17:37] What's the Effect of Vaccines on the Immune System that Makes a Significant Health Challenge? Long-term COVID-19 is linked to IgG4 disease, characterized by an immune system overreaction leading to tissue swelling and fibrosis. This previously rare condition is now seen more frequently due to the COVID-19 pandemic and related vaccines. Vaccines can trigger an immune response that produces spike proteins indefinitely, leading to continuous inflammation and fibrosis. This response lacks an "off switch," which presents a significant health challenge. To help manage this ongoing reaction, proteolytic enzymes, such as natto kinase and serrapeptase, may break down the spike proteins and fibrosis. Over time, lysosomes, the cellular "recycling centers," can become overwhelmed with proteins they cannot break down and gradually transform into "landfills." This shift may be a primary factor behind accelerated aging. The key to managing long-term health effects, particularly in COVID-19, is to support the body's protein digestion mechanisms and clean out lysosomes, potentially slowing the aging process. [26:16] What Dietary Adaptation Techniques Are Useful Over the Long Term? If you have a histamine problem, you can make significant improvements by modifying your environment and diet. Still, structural damage caused by inflammation from histamine may take longer to heal. Food reactivity is a spectrum, not a binary state. Some may be highly allergic to certain foods but only mildly reactive to others. Begin reintroduction with foods you are mildly reactive to. Over time, humans have selectively cultivated plants to have fewer toxins (anti-nutrients) and more desirable traits like sweetness. This has pros and cons, including the loss of some beneficial anti-nutrients. Some anti-nutrients can have medicinal value and defend against viruses, fungi, parasites, bacteria, and even cancer. Knowing which plants to avoid is crucial due to their high content of harmful anti-nutrients, like soy and spinach, which can harm our thyroid function and cause conditions such as kidney stones. A general guideline is to stay away from oxalates. [36:26] What's the Importance of Raw Meat and Protein? Raw meat contains a variety of proteins and peptides, which could be beneficial for anti-aging and overall health, which may be altered or reduced during the cooking process. Cooking meat releases glutamate, a flavor-enhancing amino acid, which can cause adverse reactions in some individuals, such as headaches or shaking. The cooking process can also lead to the creation of glycation products which can contribute to aging and other health issues. To mitigate the formation of glycation products during cooking, marinate your meat and cook with some acid, such as lemon juice. Recognize your sensitivity to glutamate. If you're not sensitive, you may only need to reduce your consumption of high-glutamate foods. If you are sensitive, more drastic dietary changes may be required for your well-being. [42:10] What's the Role of Olive Oil in Nutrient Delivery and Fuel Source? While olive oil has many health benefits due to its oleocanthal and polyphenols content, it does not necessarily negate its glycation content. Olive oil should be used in moderation, not as a main fuel source but as a nutrient delivery mechanism. This supports the absorption of fat-soluble nutrients from other foods. Balancing the intake of different food groups like low glycemic grains, beans, and fats can provide a more balanced energy source. Individuals who consume large amounts of oil may need to increase their protein intake accordingly. It's important to protect the lysosomes, cellular components involved in waste disposal, especially when consuming large quantities of a particular food. [51:53] What Are the Benefits of The Carnivore Diet? The microbiome plays a significant role in overall health and requires prebiotics for optimal function, found primarily in plant-based foods. Carnivore diets may be short-term beneficial but can lead to a lack of necessary prebiotics over time. Introducing a range of plant-based foods gradually can maintain a healthy microbiome. Lysosomes, the organelles in cells responsible for digesting fats and proteins, can become overloaded by misfolded proteins and hydrogenated fats, leading to neurologic conditions. Regular detoxification of metals and minimizing intake of misfolded proteins and hydrogenated fats can help maintain lysosomal health and aid graceful aging. Introducing substances like cyclodextrins can help maintain lysosomal health by clearing out hydrogenated fats and misfolded proteins, especially for individuals following high-fat diets like keto or carnivore diets. AND MUCH MORE! Resources from this episode: Website: https://remedylink.com/ Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
A new, recently published study found that the more COVID-19 shots a person received, the more weakened their immune system becomes. The researchers laid out within the study the mechanism by how this happens, which has to do with the spike in production of IgG4 anti-bodies within the vaccine recipient's body. A new body of research has recently discovered that these IgG4 anti-bodies are not benign, but can lead to a plethora of problems for the human body, including cancer, organ dysfunction, organ failure, and even death. The technical name for this is IgG4-Related Disease. ⭕️ Sign up for our NEWSLETTER and stay in touch
A new, recently published study found that the more COVID-19 shots a person received, the more weakened their immune system becomes. The researchers laid out within the study the mechanism by how this happens, which has to do with the spike in production of IgG4 anti-bodies within the vaccine recipient's body. A new body of research has recently discovered that these IgG4 anti-bodies are not benign, but can lead to a plethora of problems for the human body, including cancer, organ dysfunction, organ failure, and even death. The technical name for this is IgG4-Related Disease. ⭕️Watch in-depth videos based on Truth & Tradition at Epoch TV
Dr. Jack Cush reviews the news and reports from the past week on RheumNow.com. This week a new colchicine FDA approval, rising rate of IgG4 related disease and what's the safest biologic?
5 questions for the GIRL Joe Biden's bosses chose to run the CDC and why The Party needs Walensky clones.You probably observe the same pattern: so-called “public ‘health'” officials are one of two types of people: evil and scheming or compliant supplicants to evil and scheming. Is this nature of nurture? I think it's both. Our medical schools are co-opted by pharma, the public health system is co-opted by pharma, our CDC and FDA ARE pharma. They all nurture well meaning young people into becoming either evil and scheming or compliant servants of evil schemers. This has never been more clear than in the case of the girl--and, she is quite clearly too immature to be called a woman--whom the people who run Joe Biden want as the FigureHead over the CDC. Oh . . . if people think this is just about Covid, please let me remind you that this girl and people like her are the same people who will be told to approve brain implants in people, mRNA in food supplies, mosquitoes spreading mRNA against people's wishes and more. This is the battlefront. Why were you laughing and giggling with your girlfriend about shutting down the American economy?Are you capable of restoring trust? Are you capable of telling the truth? Exactly how many HEALTHY kids who had NO comorbid conditions died from Covid? Why should anyone believe you -- for instance, can you name one, single factor you got right about Covid, masks, injections or lockdowns? What does God's Word say? Proverbs 6:16-19 There are six things that the Lord hates, seven that are an abomination to him: haughty eyes, a lying tongue, and hands that shed innocent blood, a heart that devises wicked plans, feet that make haste to run to evil, a false witness who breathes out lies, and one who sows discord among brothers.Psalm 37:1-40Fret not yourself because of evildoers; be not envious of wrongdoers! For they will soon fade like the grass and wither like the green herb. Trust in the Lord, and do good; dwell in the land and befriend faithfulness. Delight yourself in the Lord, and he will give you the desires of your heart. Commit your way to the Lord; trust in him, and he will actEpisode 874 Links:New CDC Director Mandy Cohen recalls how she and her colleagues came up with COVID mandates during her time as NC Health Director. “She was like, are you gonna let them have professional football? And I was like, no. And she's like, OK neither are we.”By the way, Mandy Cohen apparently only masks when there's a camera around. Here she walked into the press conference unmasked, not realizing a camera caught it. This was June 30, 2020, a couple months before she tweeted the photo of the Fauci mask.Fauci and Pfizer Lied to Trump About COVID-19 Vaccine, Claims NavarroOur 1st COVID-19 mRNA vaccine paper was accepted & went viral! mRNA vaccines make IgG4 which suppresses the immune system, causing COVID re-infections, autoimmune diseases (myocarditis) & cancer!Family of College Student Who Died From COVID-19 Vaccine Sues Biden AdministrationSo-called ‘Gender-Affirming' Surgery Leaves People Lonelier and Depressed, Study by Transgender Surgery Department Chairman FindsForget all the complex arguments explaining why we must resist the WHO treaty amendments. All you need to know is who'll be in charge of the WHO's Behavioural Insights team enforcing future lockdowns & vaxx mandates - without our Govt consent Elon Musk's Brain Implant Firm Says U.S. Has Approved Human TestsUS air force denies running simulation in which AI drone ‘killed' operator; Denial follows colonel saying drone used ‘highly unexpected strategies to achieve its goal' in virtual test4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. BiOptimizers https://magbreakthrough.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. 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In this episode, Tiffany will discuss how different organs can be impacted by the disease and the difference between an organ being part of a disease and being a comorbidity. Tiffany will be exploring some examples of organs being affected in various diseases such as eyes, heart, gastrointestinal, and kidneys, as well as a newer autoimmune disease, IgG4, that is commonly being diagnosed for patients alongside their AiArthritis disease. It is crucial for patients to be proactive in their healthcare by asking their healthcare provider about organ involvement - as part of their disease or as a potential comorbidity- and what steps they can take to next manage their health. This episode is just the start of this conversation! Tiffany will be joined by Eileen and Deb at EULAR 2023 in Milan, Italy, as part of our “Go With Us!” To Conferences program. While there we will be recording updates for you from all sessions that cover this topic, which will be available soon after on our YouTube channel/Go With Us! to EULAR 2023 playlist. Want to get insider information from our visit to EULAR 2023 and first notification of new materials we create from attending? Sign up at https://www.aiarthritis.org/conferences Share your AiArthritis disease comorbidities questions with us here! info@aiarthritis.org Subject: Comorbidities Episode Highlights: Understanding the complexities of comorbidities with AiArthritis diseases Sharing the different comorbidities that commonly occur with AiArthritis diseases Learn which organs are commonly affected by comorbidities and what your risks are Understand IgG4, a newer autoimmune disease more and how it may be diagnosed alongside AiArthritis diseases How to attend conferences with AiArthritis and learn more about comorbidities Learn more about your AiArthritis disease by joining us at conferences, sharing your questions, joining AiArthritis Voices service or participating in the AiArthritis Research Database Our Co-Hosts: Tiffany is the CEO at International Foundation for AiArthritis and uses her professional expertise in mind-mapping and problem solving to help others, like her, who live with AiArthritis diseases work in unison to identify and solve unresolved community issues. Connect with Tiffany: Facebook: @TiffanyAiArthritis Twitter: @TiffWRobertson LinkedIn: @TiffanyWestrichRobertson Donate to Support the Show: https://www.aiarthritis.org/donate Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE AiArthritis Voices 360 is produced by the International Foundation for Autoimmune and Autoinflammatory Arthritis. Visit us on the web at www.aiarthritis.org/talkshow. Find us on Twitter, Instagram, TikTok, or Facebook (@IFAiArthritis) or email us (podcast@aiarthritis.org). Be sure to check out our top-rated show on Feedspot!
Osteoarthritis (OA) is the most common form of arthritis. There are currently no effective disease-modifying treatments available to slow or reverse the progression of OA. Drugs such as metformin, which is commonly used to treat type 2 diabetes are generally safe and low cost. Research has been shown that metformin has anti-inflammatory and pro-weight loss effects, suggesting that the use of metformin may be useful in the treatment or prevention of OA. Dr Matthew Baker joins us on this week's episode of Joint Action to discuss this important topic. Dr. Matthew Baker is the Clinical Chief in the Division of Immunology and Rheumatology at Stanford University. He received his bachelor's degree from Pomona College, his medical degree from Harvard Medical School, and his master's degree in Epidemiology and Clinical Research from Stanford University. He completed his Internal Medicine residency at the Massachusetts General Hospital and his Rheumatology fellowship at Stanford University. Dr. Baker has established a clinical research program that is focused on clinical trials, epidemiological studies, and bench-to-bedside translational research. He has designed and led investigator-initiated and industry sponsored clinical trials with a focus on sarcoidosis, IgG4-related disease, and rheumatoid arthritis. In addition, he is the Co-Director of the Stanford Multidisciplinary Sarcoidosis Program and collaborates with other team members to advance sarcoidosis clinical care and research.RESOURCESDevelopment of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a SulfonylureaIncreased risk of osteoarthritis in patients with atopic diseaseCONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgEmail: hello@jointaction.infoWebsite: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review! Hosted on Acast. See acast.com/privacy for more information.
Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Tangled web of wires (Nature) Path to group A Streptococcus vaccines (Clin Inf Dis) Immune end-types predictive of vaccine responses (Nat Immunol) IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol) Very bad B cells (Immunity) Two epitope Streptococcus monoclonal (EMBO Mol Med) Predictor of vaccine-induced antibody responses (Nat Immunol) Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med) Neutrophilic inflammation and RSV infection (Science) Commensals avoiding recognition (Sci Immunol) Continuous germinal center invasion and immune response diversity (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
CardioNerds Cofounder Dr. Amit Goyal join Dr. Usman Hasnie and Dr. Will Morgan from University of Alabama at Birmingham for a hike up Red Mountain. They discuss the following case: A 75-year-old woman with prior mitral valve ring annuloplasty presented with subacute, intermittent, self-limiting neurologic deficits. Brain MRI revealed multiple subacute embolic events consistent with cardioembolic phenomena. Transesophageal echochardiogram discovered a mobile mass on the mitral valve as the likely cause for cardioembolic stroke. She was taken for surgical repair of the mitral valve. Tissue biopsy confirmed that the mass was an IgG4-related pseudotumor. Expert commentary is provided by Dr. Neal Miller (Assistant Professor of Cardiology, University of Alabama at Birmingham). Audio editing by CardioNerds Academy Intern, student doctor Adriana Mares Check out this published case report here: IgG4-Related Disease Masquerading as Culture-Negative Endocarditis! CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Cardioembolic Stroke due to an IgG4-related pseudotumor Surgical indications for endocarditis include severe heart failure, valvular dysfunction with severe hemodynamic compromise, prosthetic valve infection, invasion beyond the valve leaflets, recurrent systemic embolization, large mobile vegetations, or persistent sepsis (in infective endocarditis) despite adequate antibiotic therapy. IgG4 related disease is rare, and likely underrecognized due to the lack of reliable biomarkers. Biopsy and histologic confirmation are imperative to clinch the diagnosis. Cardiac manifestations of IgG4-related disease are rare but are often related to aortopathies. Valvular disease is extremely rare as a manifestation of the disease. Treatment of IgG4 related disease includes steroids as the first line treatment. IgG4 related disease requires a multi-disciplinary approach to both diagnose and treat. Show Notes - Cardioembolic Stroke due to an IgG4-related pseudotumor Notes were drafted by Dr. Hasnie and Dr. Morgan IgG4-related disease has a very diverse presentation including mimicry of infection, malignancy and other autoimmune conditions. It is a fibroinflammatory condition that results in deposition of IgG4 positive plasma cells. It has been described in multiple organ systems including the pancreas, kidneys, lungs and salivary glands. Cardiac manifestations are extremely rare and valvular disease even more so. There are thirteen cases of IgG4 related valvular disease, and of these only two had mitral valve involvement such as this case. The most commonly reported cardiovascular manifestations are related to aortopathies. This disease remains poorly understood at this point. There are no true biomarkers that can be used to risk stratify the diagnosis for clinicians. Biopsy is imperative to the diagnosis. Even serum IgG4 levels are normal in 30% of cases despite meeting histologic criteria on biopsy making the diagnosis incredibly difficult to make. While guidelines have not been developed to guide treatment of IgG4-related disease, steroids are considered the first line treatment option for patients. Often times dosing is 2-4 weeks with a prolonged taper. When looking for glucocorticoid sparing agents, azathioprine, mycophenolate mofetil, and methotrexate are considered alternatives. References - Cardioembolic Stroke due to an IgG4-related pseudotumor 1. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4- related autoimmune disease. J Gastroenterol 2003;38:982-4. 2. Deshpande V, Zen Y, Chan JK, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-1192. doi:10.1038/modpathol.2012.72 3. Dahlgren M,
Dr. Prather opens the show with two segments dedicated to our "Health Freedom Update". Then, we talk about why having a Health Coach is important to help you to reach your fat loss goals. In this episode, find out:—Why we are changing the name of our "COVID Update" segment to our "Health Freedom Update" after three years.—What is happening right now with a child care crisis as the country has a "triple-demic" of flu, RSV, and COVID. And the reason why the immune systems in children are compromised right now as a result of the lockdowns and isolation. —The major change in their COVID policy that the Communist regime in China just made after their people rose up in protest. And why Dr. Prather says that the surge of COVID in China proves that "lockdowns don't work, masks don't work, and the vaccines don't work".—How the current COVID vaccine is ineffective against the current COVID variants. And how you are more susceptible to get the latest variants the more shots and boosters that you receive. —The mechanism of the vaccine that triggers an IgG4 response in your immune system that treats the COVID variants as a harmless pollen instead of as a more dangerous virus. And how this same response was previously seen in RSV vaccination campaigns in Africa that made it more likely for someone who was vaccinated to get RSV. —The increased risk of Myocarditis and Pericarditis in young men and athletes who have received the COVID vaccine, which has caused other countries to actually ban the vaccine for young men.—How you can protect yourself and your loved ones by building up your immune system. And the "critical" importance of correct diagnostics to find out the exact state of your health (such as Vitamin D, Zinc, and Iodine levels).—The story of Robert, a patient at Holistic Integration, and how he lost 45 pounds in his first three months on our Fat Loss Program! —Why having a Health Coach to guide and encourage you is so important when you are trying to make positive, long-lasting changes in your health. —How you can get a free consultation with our Health Coach (which includes a Body Composition Analysis and Fit3D Scan) by attending our free Open House Event on Wednesday, January 11th at 6 p.m.http://www.TheVoiceOfHealthRadio.com
In this 155th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we discuss the state of the world through an evolutionary lens. This week, we discuss USDA organic certification, Whole Foods, and why people make inconsistent decisions in their own lives. We talk about new research published in Science Immunology that finds that the degree to which people are mRNA vaccinated against Covid is correlated with a paradoxical immunological response (with regard to IgG4). We discuss new research published in The Lancet, which pretends to be about how women are faring with monkeypox, but is actually largely about men who are pretending to be women; we also review The Lancet's final op-ed of 2022, which bemoans a “breakdown of trust in the state and in scientists.” Finally, we discuss how glass frogs become transparent: by sequestering blood in their livers. ***** Support the sponsors of this show: Thesis: personalized nootropics for motivation, creativity, confidence and more. To get a customized Thesis starter kit, take the quiz at takethesis.com/DARKHORSE, and use code DARKHORSE at checkout for 10% off your first box. Eight Sleep: Personalized thermoregulation while you sleep, and when you wake. Eight Sleep's amazing Pod Pro Cover (for your mattress) is $150 off at www.eightsleep.com/darkhorse Sole: Beautiful shoes and carefully designed footbeds for healthy feet. Go to https://yoursole.com/darkhorse , and first-time customers get 50% off any footbed, plus they have a 90-day money back guarantee. ***** Our book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, and signed copies are available here: https://darvillsbookstore.indielite.org Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com Find more from us on Bret's website (https://bretweinstein.net) or Heather's website (http://heatherheying.com). Become a member of the DarkHorse LiveStreams, and get access to an additional Q&A livestream every month. Join at Heather's Patreon. Like this content? Subscribe to the channel, like this video, follow us on twitter (@BretWeinstein, @HeatherEHeying), and consider helping us out by contributing to either of our Patreons or Bret's Paypal. Looking for clips from #DarkHorseLivestreams? Check out our other channel: https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIA Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music. ***** Q&A Link: https://youtu.be/8sb6jRZidlA Mentioned in this episode: USDA Organic Certification (two links): https://www.usda.gov/media/blog/2020/10/27/organic-101-allowed-and-prohibited-substanceshttps://www.usda.gov/media/blog/2012/10/10/organic-101-five-steps-organic-certificationIrrgang et al 2022. Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. Science Immunology, p.eade2798. https://www.science.org/doi/full/10.1126/sciimmunol.ade2798 IgG4-related disease (IgG4RD) means FIBROSIS and organ destruction (Jessica Rose, 12-28-22): https://jessicar.substack.com/p/igg4-related-disease-igg4rd-means Trainwreck of all trainwrecks (12-24-22): https://www.rintrah.nl/theSupport the show
Regular listeners to Raise the Line know so-called "rare diseases" aren't really rare when you consider up to thirty million Americans are affected by them directly. That makes it likely you know someone who is impacted, or you know one of their colleagues, friends or loved ones. That fact has hit home at Osmosis over the last few months as we've started planning a major focus on rare diseases for 2023, which we're calling The Year of the Zebra. Several teammates have come forward to tell us their rare disease stories and we'll be sharing some of those on the podcast in the coming months. First up is our Director of Nursing Education Dr. Maria Pfrommer and her husband, Jack, who join host Shiv Gaglani to offer insights into the diagnosis and treatment journey they've been on to deal with Jack's battle with retroperitoneal fibrosis, an inflammatory condition which can cause obstructions in the urinary tract. While Maria's vast clinical knowledge and experience in healthcare systems has obviously been helpful, it was still a struggle to get the right diagnosis and treatment due to limited experience among healthcare professionals with rare conditions. “From my perspective, I really think that we need to learn more about rare disorders from every level of care,” she says. Tune in for great real-world advice for healthcare professionals dealing with rare disease patients including the importance of listening to the patient, understanding their whole life picture and focusing on transitions of care.
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