Podcasts about statistically

Looking 4 Healing Radio with Dr. Angelina Farella – The pharmaceutical industry has overtaken many of the institutions of higher learning. Research is also being corrupted with the pharmaceutical companies paying for their own research, and the bias of the research is in favor of whatever medication is being analyzed. Statistically speaking, the numbers are being manipulated to make the...

Looking 4 Healing Radio with Dr. Angelina Farella – The pharmaceutical industry has overtaken many of the institutions of higher learning. Research is also being corrupted with the pharmaceutical companies paying for their own research, and the bias of the research is in favor of whatever medication is being analyzed. Statistically speaking, the numbers are being manipulated to make the...

QAnon-style trafficking myths are hurting real victims and helping nobody. Nick Pell separates trafficking fact from fiction here on Skeptical Sunday.Welcome to Skeptical Sunday, a special edition of The Jordan Harbinger Show where Jordan and a guest break down a topic that you may have never thought about, open things up, and debunk common misconceptions. This time around, we're joined by writer and researcher Nick Pell!Full show notes and resources can be found here: jordanharbinger.com/1215On This Week's Skeptical Sunday:The math doesn't add up. That viral "800,000 missing children" claim? Pure statistical sleight of hand. Most are runaways or parental custody disputes, not shadowy trafficking rings. The reality is that stranger abductions account for just one percent of kidnapping cases.Forget the Hollywood playbook. Real trafficking isn't a panel van at Walmart waiting for the perfect victim to whisk away — it's the slow burn of grooming. Predators pose as boyfriends, exploit trust, and use psychological manipulation over months.Privilege blinds us to real victims. That suburban soccer mom convinced she's a trafficking target? Statistically safer than she thinks. Actual victims tend to come from marginalized communities, LGBTQ+ youth, immigrants, and kids in foster care — people society already overlooks.Moral panic creates real harm. Trafficking hysteria spawned laws like SESTA/FOSTA that pushed sex work underground, making it more dangerous. When we chase fictional threats, we abandon real victims who need unsexy, long-term support — not rescue fantasies.Real solutions work through boring, beautiful basics. Want to actually help? Support organizations like Polaris Project that provide housing, mental health care, legal aid, and job training. One person at a time, one life rebuilt — that's how you dismantle trafficking networks for real.Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Rag & Bone: 20% off: Rag-Bone.com, code JORDANWayfair: Start renovating: wayfair.comBetterHelp: 10% off first month: betterhelp.com/jordanLand Rover Defender: Build yours: landroverusa.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Statistically, your odds of becoming an astronaut are close to zero. You have to make some pretty extreme sacrifices to reach the stars, and that's the thrust of a new novel about the first Cherokee astronaut. To the Moon and Back is Eliana Ramage's debut novel and the September pick for Reese Witherspoon's book club. It's a book about ambition and astronauts, but it's also about what it means to be Indigenous … in the past, present, and future. This week, Eliana tells Mattea about loving the story of science, writing frustrating characters and why she's taking Cherokee identity to Mars. Liked this conversation? Keep listening:Taylor Jenkins Reid is among the stars — on and off the page For Indigenous players, ice hockey is a ceremony of its own

Looking for more DTP Content? Check us our here: www.thereadinesslab.com/dtp-linksIn Part 2 of this three-part series, host John Scardena continues his conversation with Jim Balthazar, drawing on Jim's background in law enforcement, ATF Special Response Teams, and faith-based security leadership to unpack lessons from high-profile incidents and what they mean for community safety today.Topics Covered in Part 2The Charlie Kirk incident — rooftop vulnerabilities, the difference between local security resources and federal protective standards, and how evolving threats require new approaches such as counter-sniper teams, drones for observation, and protective design changes.Historical parallels — from JFK to modern-day open-air events, how notoriety and visibility create unique risks.Schools and safety drills — why “run, hide, fight” isn't always effective, the role of barricading, and why empowerment strategies can make a difference for students and staff.The role of parents and families — parents as the first line of defense, age-appropriate conversations with children, and the importance of monitoring online influences.Mitigation and risk management — balancing statistical rarity with catastrophic impact, and how organizations can prepare without creating paranoia.Key TakeawaysHigh-profile figures and open-air venues face unique risks that demand proactive security planning.Statistically rare events can still have catastrophic consequences, making risk management essential.Training and age-appropriate preparation for schools and families are more effective than fear-based approaches.Parents play a critical role in monitoring, guiding, and shaping safe environments for kids.Security must adapt as threats evolve — from rooftops to classrooms to community gatherings.Part One: Leadership in the FieldPart Three: Church SecurityMajor Endorsements: ImpulseBleeding Control Kits by Professionals for Professionalshttps://www.impulsekits.com Doberman Emergency Management Subject matter experts in assessments, planning and training https://www.dobermanemg.com The Readiness Lab Trailblazing Disaster Readiness through podcasts, outreach, marketing, and interactive eventshttps://www.thereadinesslab.com For Sponsorship Requests contact@thereadinesslab.com 314-400-8848 Ext 2#DisasterToughPodcast #EmergencyManagement #CrisisLeadership #DisasterResponse #ActiveShooterAwareness #PublicSafety #Resilience #SchoolSafety #IncidentCommand #SecurityLeadership #RiskManagement #CharlieKirk #UVU #ChurchSecurity

Notre Dame travels to Arkansas to face the Razorbacks in an ABC-televised game kicking off at 11 Central in Week 5 of the 2025 college football season. Jay Greeson and Chris Lee preview the game, with topics including: Arkansas quarterback Taylen Green is a one-man wrecking crew who can win games with outstanding performances. But the Razorbacks have to stop shooting themselves in the foot with turnovers and untimely penalties. Notre Dame was torched by Texas A&M's Marcel Reed in the passing game two weeks ago, providing some hopes for an Arkansas upset. The Razorbacks were also awful against the run vs. Memphis, and now face one of the country's top running backs in Jeremiyah Love. Statistically, Arkansas's defense is better than Notre Dame's in some categories, but the Fighting Irish's schedule has included Miami and Texas A&M. With coach Sam Pittman on the hot set, is a home game here the best or worst thing that could happen to Arkansas? And how much are the Razorbacks bought into playing for Pittman? Finally, the Irish have to win this one to stand any chance to make the Playoff. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Episode: Built Not BornGuest: Guy Kawasaki - Former Apple Chief Evangelist, Author of "Wiser Guy"Host: Joe CiccaroneRelease Date: September 22, 2025

Why Bureaucracy, Hollywood, and the NRA Helped Serial Killers ThriveWhy does America remain the global epicentre of serial killers? In Part Two of Psycho Killer: Shocking True Crime Stories, Simon Ford and Jacques Morrell uncover how bureaucracy, pop culture, and gun culture shaped the rise of American serial murderers.From the FBI's behavioural profiling to the National Rifle Association's influence, from Hollywood's romanticisation of killers to the chilling question of whether Millennials and Gen Z will break the cycle, this episode digs deeper into America's darkest shadows.We examine cases where red tape let killers roam free, the dangerous glamorisation of Bundy and Dahmer, and how easy access to firearms made serial murder uniquely lethal in the United States.Support us on Patreon for just £5 a month.TranscriptWhat if the system that's meant to protect you is the very thing that lets a killer slip through the cracks? What if the weapons are legally bought and the warning signs ignored? What if Hollywood's obsession with serial murder isn't just entertaining, but prophecy? In Part Two of 'Why Does The United States Have More Serial Killers Than Any Other Country On Earth?' we ask: has America created the perfect breeding ground for serial murderers and psychopaths? And as we race towards 2030, is there still time to stop the next one? But before we dive in, a quick shout out to our friends at Podcast Today, that's podcast dot today. They featured our Ian Huntley episode, 'A Psychopath at School', in their Quick Listens category. If you love discovering new true crime stories, head to podcast dot today and see what else they've lined up. It's free, it's daily and it's curated just for you. Welcome back to Psycho Killer: Shocking True Crime Stories. I'm Simon Ford and I'm Jacques Morrell. If you haven't heard part one yet, hit pause and listen to that first. We explored the growth of suburbia, the aftershocks of war, and the cracks in American policing. Today, in part two, we widen the lens. Bureaucracies that enable killers. Pop culture that glorifies them, guns that empower them, and a generation that might just change everything. Welcome to NBC News Daily. This Tuesday, we're going to start with breaking news. Quadruple murder suspect Austin Drummond is in custody after an intense days long manhunt in Tennessee. Drummond was wanted for the killings of four people, all members of the same family. We've talked about fragmented law enforcement. We've examined the challenges of jurisdictional chaos and under-resourced police departments. But there's another, less visible force at play in the story of America's serial killers. Something deeper, something colder. Bureaucracy? Yeah. Killer bureaucracy. It might sound like the title of a dystopian novel, but in real life, it's one of the quiet enablers of mass murder. Behind many of America's most notorious cases, you'll find crucial opportunities missed, not through lack of intelligence or even intent, but because the gears of the system ground too slowly or didn't turn at all. I think Mr. Little will get his final judgment. Before he died at 80 year old Samuel Little sketched the faces of the women he killed. And I'm sure these jurisdictions will go and try to connect the dots to deal with what he's come to. Take Samuel Little, for example. Officially recognised as America's most prolific serial killer. 89 confirmed victims, possibly over 90. He operated across state lines from the 1970s into the 2000s, murdering vulnerable women, mostly women of colour. And yet, for decades, law enforcement agencies failed to connect the dots. Why? Well, part of it is what we've already discussed decentralised policing. But even what agencies did have the information, there was no unified system compelling them to share that information in a usable way. For much of Little's killing spree. His victims weren't even being recorded as linked cases. And here's the irony. In 1985, the FBI launched ViCAP, the violent criminal apprehension program designed specifically to catch serial offenders by identifying patterns in unsolved cases. But ViCAP was optional. Local departments weren't required to use it. Many didn't. There are 60 confirmed victims so far. Authorities will continue the hunt for the dozens of others. It won't stop, even though little is dead. You know, you just take in for what it's worth. And people like me live with that. And that's bureaucracy for you. A powerful tool. Locked in a cupboard. Because nobody mandate the key. The FBI is still actively searching for information to connect the dots in several of Little's murders. If you have any information, call this number one 800. Call FBI. The weekend I picked up a woman backpack, I weighed. And Matthew was next to me in the seat, and she hopped in. And then two and three. And my son was there, and I killed her. They'll. Sure my son didn't see it, but that only happened one time. So why didn't you do it again? I didn't want my son to see it. And that brings us to something that should chill. Anyone listening to this? In the case of Gary Ridgeway, the green River killer, dozens of women died while multiple police departments worked in silos hoarding information. Detectives even suspected Ridgeway early on. But internal politics and procedural rigidity meant he slipped through their fingers. He kept getting interviewed, kept passing polygraphs. He even gave a cheek swab DNA sample in 1987, but they didn't have the resources to process it properly. Not until the early 2000. That delay. It wasn't because no one was working the case. It was because the system was working exactly as designed, just too slowly. And there's something tragic about that. These weren't rogue officers. This wasn't corruption. This was paperwork. Process. Budgetary constraints. Misalign and incentives. In short, bureaucracy. Now, let's be fair. There have been improvements.   ViCAP is more widely used now. DNA databases are better integrated, but there's still no national mandate for data sharing in violent crime investigations. You've still got over 18,000 separate law enforcement agencies in the United States, and no centralised leadership structure. Compare that to the U.K., where a single body like the National Crime Agency can operate across the country. Or Canada's RCMP. In the US, you've got sheriff's departments, city police, state bureaus, federal agencies all working side by side, just not always together. And it's the gaps in those seams where monsters slip through. The killer may be holding the knife. But too often the system is holding the door. So what can be done? That's the million dollar question. Reform, decentralisation,  improved training, cross-agency collaboration. These are all part of the conversation. But until bureaucracy becomes more nimble, more coordinated, and more accountable, serial killers will keep finding places to hide. And we'll keep digging into the stories. The stories that reveal just how much damage can be done when no one is steering the ship. It's a firearm in the course of that murder, which is a violation of Penal Code section 12-0-22.5. Do you admit or deny that? I admit. It is further legend in counts 2 through 13... Now we're going to talk about the elephant in the room. The Second Amendment. It's just 27 words long and ratified in 1791. A well-regulated militia being necessary to the security of a free state, the right of the people to keep and bear arms shall not be infringed. At the time, the fledgling United States didn't have a standing army. The founders feared tyranny from without and within. The idea was that every able bodied citizen could take up arms to protect the Republic. But here in the 21st century, bearing arms has morphed into something far more removed from that original context. You don't need to be in a militia. You don't need to register your guns. In many states, and in some places, you don't even need a background check at a gun show. That's not what George Washington had in mind. And if you think we're anti-gun, then hold that thought, because there is an irony here. In a country with a disproportionate number of serial killers, maybe owning a .38 revolver for home defence is, well, just plain common sense. Let's get forensic. Do serial killers actually use guns? Statistically, no. Most serial killers prefer up close and personal methods. Strangulation, blunt force knives. Because for many of them, it's not about killing. It's about control. Exactly. Ted Bundy used a crowbar. Jeffrey Dahmer drugged his victims, then strangled them. John Wayne Gacy, he used rope, torture and pain. A lot has happened in just the past 24 hours as the sniper manhunt literally went nationwide. It began with a task force phone tip from someone claiming responsibility for the sniper killings. One of the few exceptions was the D.C. sniper case. In 2002, John Allen Muhammad and Lee Boyd Malvo. They used a Bushmaster .223 rifle hidden inside the trunk of a blue Chevy Caprice. Random, distant, terrifying but isolated. Don't forget that most serial killers want that proximity. They want intimacy. And that's what makes them so disturbing. They're not looking to pick off targets at a distance. They want to look you in the eye. Police in Nashville are releasing this chilling surveillance video showing the terrifying moments the shooter blasted their way into the small, private Presbyterian school. But while serial killers themselves rarely rely on guns, the wider epidemic of gun violence in America is impossible to ignore. The video also shows the armed person entering a church office and later stalking the halls with an AR-style weapon drawn. Become a supporter of this podcast: https://www.spreaker.com/podcast/psycho-killer-shocking-true-crime-stories--5005712/support.

Wanting to try for a vaginal birth after having a previous C-section? This week's episode of the podcast is for you.We interview Dr Peter Jurcevic about TOLAC (Trial of labour after a C-section) / VBC (viginalbirth after C-Section) We discuss:- What a vaginal birth after a caesarean (VBAC) / TOLAC entails- How common is it for women to have a VBAC/ TOLAC?- Why might a woman choose to have a VBAC instead of a scheduled caesarean- What the risks/ potential complications involved when choosing to have a VBAC are- Statistically how likely is a uterine rupture when having a VBAC/TOLAC- The pros of choosing a VBAC/TOLAC- The cons of choosing a VBAC- The factors that would make someone a good candidate for a VBAC- The medical factors that would make someone a risk of having VBAC- What the hospital policies around VBAC/TOLAC's are- The monitoring process for women attempting a VBACNever forget Parents You've Got This The Expert Guide To Parenthood Podcast is proudly supported by Mustela natural origin skincare, by parents' side since 1950.Follow us Social :Instagram: @parentsyouvegotthis_auThreads @parentsyouvegotthis_auTikTok: @partentsyouvegotthis_auFacebook:@parentsyouvegotthis__________________________________Parents You've Got This offers antenatal and postnatal parenting education and Masterclasses from the planning phase to early preschool.Learn more: parentsyouvegotthis.com.auCredits: Producer Dean Thomas, Camera person Tim Hehir, Content and Hosts Parents You've Got ThisThank you Think HQ for the beautiful podcast recording space

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: kids' A1C and tech access correlation, first generic GLP-1 for weight loss approved, Metformin cuts long covid risk, Tandem Diabetes & Eversense updates, and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links:   Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX Accessibility to modern diabetes technology directly correlates with A1c among children with type 1 diabetes globally. Big, cross-sectional study, conducted in 81 pediatric diabetes centers in 56 countries, found that a greater extent of reimbursement for continuous glucose monitoring (CGM), insulin pumps, glucose meters, and insulin was associated with lower A1c levels. Partha S. Kar, MD, Type 1 Diabetes & Technology lead of the National Health Service England, told Medscape Medical News, “As is now being shown in countries such as UK with widespread uptake of technology, there is now population-wide shift in A1c not seen before.”   He added, “If policymakers are serious about bringing A1c at a population level to sub-7.5% - 8% levels, then without technology it would be incredibly difficult to achieve, in my experience and opinion. Leaving the median A1c of a population at above 7.5%-8% goes with complications so that's a decision regarding investment many will have to make in the near future.”   In an accompanying editorial, Elizabeth R. Seaquist, MD, professor of diabetes, endocrinology, and metabolism and co-director of the Institute for Diabetes, Obesity, and Metabolism at the University of Minnesota, Minneapolis, called it “striking” that access to technology in and of itself was associated with improved glycemic control, given that multidisciplinary team care is also needed to provide education and behavioral or psychological support.     https://www.medscape.com/viewarticle/diabetes-tech-access-linked-a1c-kids-t1d-globally-2025a1000nn6 XX A man with type 1 in Illinois has received the first FDA-approved islet-cell replacement treatment, Lantidra, and  he is now producing his own insulin. The treatment works by restoring the body's beta cells, potentially eliminating the need for insulin injections.   The FDA approved Lantidra (donislecel) in 2023. Lantidra uses donor cells and requires lifelong immunosuppressive drugs.     Lantidra is only available at University of Illinois Chicago Health. Other universities, such as the University of Pennsylvania, continue to do islet cell transplants as part of clinical trials. Early data has shown that a majority of participants in the Lantidra clinical study were able to achieve some level of insulin independence, but it's unclear whether the benefits of donislecel outweigh the treatment's safety risks. Nearly 87 percent of participants reported infection-related adverse events, and post-operation complications included liver lacerations, bruising of the liver (hepatic hematoma), and anemia. One patient died of multi-organ failure from sepsis, which Lantidra maker CellTrans stated was “probably related” to the use of either immunosuppression or study drugs.   In addition, some industry leaders have raised the question of whether it's ethical to commercialize the use of deceased donor islet cells. https://diatribe.org/diabetes-research/first-fda-approved-islet-cell-transplant-performed?utm_campaign=feed&utm_medium=social&utm_source=later   XX Patients in the U.S. now have access to the first generic GLP-1 treatment approved for weight loss as Teva has launched its copycat of Novo Nordisk's injected Saxenda (liraglutide).   The compound, which is a GLP-1 forerunner of Novo's semaglutide products Ozempic and Wegovy, has been approved by the FDA to treat adults with obesity and those who are overweight and have weight-related medical problems.     Saxenda also is endorsed for pediatric patients ages 12 through 17 who are obese and weigh at least 60 kg (132 pounds). The treatment is for both triggering and maintaining weight loss. Saxenda is not the first GLP-1 drug that is available as a generic. In June of last year, Teva also was the first company to launch a knockoff version of Novo's Victoza, which is the same compound as Saxenda but has been approved only for patients with Type 2 diabetes. Sales of the branded versions of both Victoza and Saxenda have declined significantly in recent years as demand for Novo's semaglutide and Eli Lilly's tirzepatide products have skyrocketed. In addition, marketers of compounded products have been aggressively competing for market share in the GLP-1 space. https://www.fiercepharma.com/pharma/saxenda-knockoff-teva-launches-first-generic-glp-1-obesity   XX Metformin could cut the risk of Long COVID by 64% in overweight or obese adults who started the drug within 90 days of infection. The large observational study, published in Clinical Infectious Diseases, analysed health records of over 624,000 UK adults with COVID-19 between March 2020 and July 2023. Among these, nearly 3,000 patients who began metformin treatment soon after diagnosis were tracked for a year. Compared to non-users, their likelihood of developing Long COVID, defined as persistent symptoms 90 days or more after infection, was dramatically lower. https://www.ndtv.com/health/metformin-cuts-risk-of-long-covid-by-64-why-the-diabetes-pill-is-not-for-everyone-9242332 XX Forty-four percent of people age 15 and older living with diabetes are undiagnosed, so they don't know they have it, according to data analysis published Monday in the journal The Lancet Diabetes & Endocrinology. The study looked at data from 204 countries and territories from 2000 to 2023 in a systematic review of published literature and surveys. “The majority of people with diabetes that we report on in the study have type 2 diabetes,” said Lauryn Stafford , the lead author of the study.   “We found that 56% of people with diabetes are aware that they have the condition,” said Stafford, a researcher for the Institute for Health Metrics and Evaluation. “Globally, there's a lot of variation geographically, and also by age. So, generally, higher-income countries were doing better at diagnosing people than low- and middle-income countries.” People under 35 years were much less likely to be diagnosed if they had diabetes than people in middle age or older. Just “20% of young adults with diabetes were aware of their condition,” Stafford said. https://www.cnn.com/2025/09/08/health/diabetes-undiagnosed-half-of-americans-wellness XX A team of Hong Kong scientists is developing an injectable treatment that could potentially improve blood flow in diabetes patients' feet, in the hopes that it will reduce the need for amputation by rebuilding tissue in the arteries.   They also hope to apply the treatment to peripheral artery disease or PAD, a condition caused by the build-up of fatty deposits in arteries that affect blood circulation in the feet. “Traditional treatments for people suffering from poor blood flow in their legs are stent implantation or bypass surgery, which is invasive,” said Wong, who is also the co-founder of a biotechnology company called NutrigeneAI. He said it was his dream to turn research in the academic field into actual clinical treatments. But he added that the team still needed three to four years for further research on the treatment.   https://www.scmp.com/news/hong-kong/health-environment/article/3324671/hong-kong-scientists-developing-new-blood-flow-treatment-aid-diabetes-patients XX   Tandem Diabetes announces Health Canada authorization for distribution of the Tandem t:slim mobile application for Android and iPhone users. The Tandem t:slim mobile app allows users to deliver a bolus from their compatible smartphone, and to wirelessly upload their pump data to the cloud-based Tandem Source platform.1 The app is expected to be available later this year.   The Tandem t:slim mobile app will be available for compatible smartphones in the Apple App Store and Google Play store later in 2025. Once available, Tandem will email eligible customers with instructions on how to download and use the app.  https://www.businesswire.com/news/home/20250904665715/en/Tandem-tslim-Mobile-App-Now-Authorized-by-Health-Canada-for-iPhone-and-Android-Phones   XX Some changes to how the Eversense CGM will be rolled out.. right now it's being distributed by Ascensia Diabetes Care.  Senseonics will take back commercial control of the year long implantable CGM on January 1 in the US and expanding worldwide throughout 2026. The change was a mutual decision, according to the two companies, which said they have signed a memorandum of understanding before a definitive agreement is hammered out by the end of the year. To get started, Senseonics is also set to acquire members of Ascensia's commercial staff—including its CGM president, Brian Hansen, who is slated to become Senseonics' new chief commercial officer. https://www.fiercebiotech.com/medtech/senseonics-retake-eversense-cgm-commercial-control-ascensia-diabetes-care XX Utrecht-based medical device company ViCentra has closed an $85 million Series D round of funding led by Innovation Industries, along with existing investors Partners in Equity and Invest-NL. The round also drew support from EQT Life Sciences and Health Innovations.   The recent capital injection will be used to expand ViCentra's manufacturing capabilities, support regulatory approvals, and strengthen commercial rollout across Europe.   The funds will also be used to launch the next-generation Kaleido 2 patch pump in Europe and prepare for entry into the U.S. market.   The global insulin delivery market is growing quickly due to the increasing number of diabetes cases and demand for effective and user-friendly solutions. The market for insulin pumps is projected to exceed $14 billion by 2034. Patch pumps are the fastest-growing segment, signalling a trend toward compact and wearable devices. And here's where ViCentra is positioned to meet this need, offering a user-friendly, sleek design-led alternative to traditional systems.   Kaleido: design-led insulin delivery Kaleido is the smallest and lightest insulin patch pump developed as a lifestyle product with a particular focus on usability and personalisation.   Designed to feel more like personal technology than a traditional medical device, Kaleido features premium materials, and users can select their own favourite aluminium shells from a range of ten preset colour options.   It integrates with Diabeloop's hybrid closed-loop algorithms (DBLG1 and DBLG2) and is compatible with Dexcom CGM sensors, positioning it within the next generation of automated insulin delivery systems.   “Kaleido is a true disruptor — small, discreet, featherlight, and beautifully designed. It empowers people with diabetes by offering a more personal and distinctive choice in both function and style. Built with empathy and precision, it honours those who live with diabetes every day. With this funding, we can now meet surging European demand and fast-track our entry into the U.S. market. This is a pivotal moment — for ViCentra, and for the community we serve,” said Tom Arnold, Chief Executive Officer at ViCentra.   Improving the quality of life for diabetic patients ViCentra, led by Tom Arnold, is on a mission to improve the lives of those with diabetes.   The company reported that demand for Kaleido in Germany, France, and the Netherlands has already exceeded initial expectations.   ViCentra will present updates on Kaleido at the 61st Annual Meeting of the European Association for the Study of Diabetes (EASD), taking place September 15–19, 2025, in Vienna.   The company plans to engage with clinicians, investors, and strategic partners to further its role in the evolving diabetes care landscape.   “ViCentra is redefining insulin pump therapy with a platform that truly centres the user experience – combining clinical performance with design simplicity and wearability,” commented Caaj Greebe, Partner at Innovation Industries. “At Innovation Industries, we invest in pioneering companies that blend world-class technology with clear commercial potential. ViCentra exemplifies this by delivering a next-generation system addressing the urgent need for better treatment options in diabetes care. We're proud to lead this investment round and partner with Tom and the team as they deepen and expand their presence in Europe and prepare for U.S. entry.”   https://techfundingnews.com/dutch-vicentra-secures-85m-to-bring-insulin-patch-pump-to-more-markets/ XX Luna Diabetes announces they've raised more than 23-million dollars in early venture capital to help continue clinical trials and build out its capacity. This is the company that wants to offer a night time only, tiny, temporary insulin pump – to supplement insulin pen use. According to the company, more than 80% of the improvements in blood sugar from automated insulin delivery systems occur while the user is sleeping. Luna launched a pivotal trial late last year. https://www.fiercebiotech.com/medtech/nighttime-insulin-patch-pump-maker-luna-diabetes-raises-236m   XX Following 15 days and 150 fingerpricks, they're here. The results of the “9 sensor samba“. And what a set of a results…   Well maybe that's overplaying it a little.   Let's just say that the outcome of this n=1 experiment wasn't quite what I expected. One of the established players came out much worse than expected, while a newcomer did a lot better.   Let's dig in, and take a look at the variation. https://www.diabettech.com/cgm/the-nine-sensor-samba-results-revealed/   XX Hard work and perseverance define ranch life, but one man in eastern Montana takes it to another level. At 90, he's still living independently on the ranch he built from the ground up. Even more remarkable? He's a type 1 diabetic.   Bob Delp still begins each day just like he did decades ago, waking up on his ranch near Richey, Montana.   “I always thought if I could ever get a ranch and run a hundred cows, that's what I wanted to do from the time I was a kid,” said Delp.   He made that dream real, the hard way; after coming home from the army, he taught school, hayed for seven cents a bale and saved every cent he could.     “I worked at it real hard because I always felt like it was going to be part of getting me to that ranch that I always wanted,” said Delp.   He did it all while managing type 1 diabetes, a diagnosis that came with few answers and little hope back in the 1950s.   “The doctors tell me being a type 1 diabetic for 66 years isn't supposed to happen. Back then, it was a real challenge,” added Delp.   Statistically, it's almost unheard of. Fewer than 90 people in the world have lived more than 70 years with type 1 diabetes.     Bob credits his late wife, Donna, for helping him beat the odds.   “She has been key in that I always ate on time.”   They've faced their share of storms, both in health and out on the land. Not long after moving to Richey, a heavy snowstorm nearly tore everything apart just after they'd stepped out for dinner.   “If Donna hadn't said it was time to eat, we wouldn't have made it out of there. I guess that's one time that made me happy to have diabetes. And I think that saved us,” said Delp.     Now, he still checks his blood sugar daily but trusts his hands more than high-tech insulin pumps.   “I'm not satisfied with the sensors they have today. I just don't think they're accurate.”   To many, Bob's survival is extraordinary. To him, it's luck.   “The genes are there already, I can't change that so I guess I would have to say just lots of good luck,” said Delp.     And through it all, optimism has been his compass.   “You might fumble the ball, but if you're determined to be a winner, you'll recover that fumble someday,” said Delp.   He still welds nearly every day. Not because he has to, but because it keeps him going.   “As long as I keep doing something like this, I will not be in the nursing home,” said Delp.   https://www.kfyrtv.com/2025/08/09/against-all-odds-montana-man-thrives-with-type-1-diabetes-90/ XX Today, Dexcom is building on this belief and breaking new ground with the launch of its first open call across the U.S. and Canada in search of the next diabetes advocates—giving people with all types of diabetes a once-in-a-lifetime opportunity to raise awareness and share their voice on a global scale in the company's World Diabetes Day campaign (Nov. 14) and beyond.  Who is eligible?: Anyone age 2+ living with all types of diabetes or prediabetes can be nominated by themselves or by someone who knows them. Selected candidates will embody strength, advocacy and pride in living with diabetes or prediabetes. Where and how can I nominate myself or someone I know?: Visit Dexcom.com/WorldDiabetesDay When is the deadline to submit a nomination?: Nominations are open from September 10 through September 19 at 12pm PT. What will the selected candidates experience?:   An invite to participate in a World Diabetes Day photoshoot in Los Angeles to have their unique story featured in Dexcom's World Diabetes Day campaign The ongoing opportunity to attend events, connect with community, and raise diabetes awareness around the world XX The European Association for the Study of Diabetes (EASD) 2025 Annual Meeting will feature major clinical trial results in type 2 diabetes (T2D), type 1 diabetes (T1D), obesity, several new clinical practice guidelines, and much more. The 61st annual EASD meeting will take place on September 15-19, 2025, in Vienna, Austria.   

Send us a textPerforming billing and documentation audits & reviews are important for an effective compliance program. In this episode, Captain Integrity Bob Wade explains what a probe review is and when you need to keep digging for a statistically valid review. Hear how to design your probe review using the RAT-STATS program, when you can treat your probe review as an educational review, when you need to do a statistically valid review, the history of RAT-STATS, and the origin of the “keep on digging” idiom. Learn more at CaptainIntegrity.com 

If you've saved more than a million dollars, that puts you ahead of 90% of your peers. Statistically, that makes you a super saver. But one of the biggest challenges super savers face is this: it's hard to spend your own money. In this episode, I share one exercise that can help break some of those old habits and open the door to a more fulfilling retirement. A Practical Exercise  Think back over the last year or two and pick a trip that you really enjoyed. Itemize all the spending decisions you can remember:  Where did you go? How did you get there? How long did you stay? What did you eat? What souvenirs did you buy?
 Take each line item and triple it. Then think of two or three ways you could possibly spend that new tripled amount.  Listen to the rest of the episode and learn how we can rewire our brains from saving mode to spending mode.   Connect with Benjamin Brandt Get the Retire-Ready Toolkit: http://retirementstartstodayradio.com Subscribe to the newsletter: https://retirementstartstodayradio.com/newsletter Work with Benjamin: https://retirementstartstoday.com/start Follow Retirement Starts Today in:Apple Podcasts, Spotify, Overcast, Pocket Casts, Amazon Music, or iHeart  Get the book!Retirement Starts Today: Your Non-financial Guide to an Even Better Retirement  

3HL - 8-14-25 - Hour 2 - Can the Titans Offense Improve Statistically in 2025? + Greg Cosell joinsSee omnystudio.com/listener for privacy information.

3HL - 8-14-25 - Hour 2 - Can the Titans Offense Improve Statistically in 2025? + Greg Cosell joinsSee omnystudio.com/listener for privacy information.

Subscribe: Apple Podcasts | Spotify | RSS This week, we're talking about marriage and whether it should be expected for Christians to marry. Statistically, the age at which Americans first get married is rising. For various reasons, marriage is being delayed or avoided altogether. Should it be this way among God's people? Should the young people […]

Mark Twain famously said, “There are lies, damn lies, and statistics“, and while it's true that numbers are often used creatively to benefit one party or another, statistics are one of the primary tools of a functioning society. Donna and Nathan walk us through some of the critical elements of our daily lives that rely on statistics, and why the firing of the head of the Bureau of Labor Statistics has garnered so much negative attention. Also on MoneyTalk, lessons from famed investor, Ray Dalio, and Stock Trivia: Two Truths and a Lie. Hosts: Donna Sowa Allard, CFP®, AIF® & Nathan Beauvais, CFP®, CIMA®, CPWA®; Air Date: 8/7/2025. Have a question for the hosts? Visit sowafinancial.com/moneytalk to join the conversation!See omnystudio.com/listener for privacy information.

The Phillies landed one of the best closers in baseball on Wednesday, getting Twins closer Johan Duran. Everybody wondered what might happen next. A big bat like Eugenio Suárez? A top-of-the-lineup threat like Steven Kwan? They got Twins outfielder Harrison Bader on Thursday.Statistically, he immediately became the Phillies' best outfielder.But is it enough?We're not so sure. We discuss the Bader deal. We discuss the short-term futures for Justin Crawford and Max Kepler. We discuss how the Phillies and Mets stack up following the trade deadline and much more.Parx Casino and betPARX are the official casino and sportsbook of TPS. New customers can download betPARX now and get up to a $1,000 dollar casino bonus back if you're not a winner in your first 24 hours. Visit betPARX.com for terms/conditions. You must be 21 and in Pennsylvania, New Jersey, Maryland or Michigan. Gambling Problem, call 1-800-GAMBLER.Phillies fans, whether you're hustling on the field or having a catch with your kids — staying mobile is everything.  That's where Rothman Orthopaedics comes in. With expert care and top docs, they keep the Phillies and Philly moving. Schedule an appointment now at https://rothmanortho.com/.Get 20% off your first Slab Pack or card purchase by going to https://ArenaClub.com/FOUL and use code FOULLove The Phillies Show? You can purchase your Phillies Show t-shirt by 47 Brand at https://www.thephilliesshow.com/shop We've got maroon and powder blue t-shirts in stock!Subscribe to The Phillies Show podcast and follow us on social media: https://linktr.ee/ThePhilliesShowWe're part of the Foul Territory Network. Follow FT and find more of its shows: https://linktr.ee/foulterritoryIf you like The Phillies Show, subscribe to the podcast and give us a five-star review!

Dr. Dre bio: Dr. Andrea Mata, PhD, is on a mission to throat-punch the mental health crisis and equip people with the tools they need to take control of their lives. Statistically, she shouldn't be where she is today—growing up as the daughter of a Mexican immigrant in a gang-infested neighborhood on the Southside of Chicago. But Dr. Mata transformed her challenging upbringing into a source of strength, inspiring resilience in families, businesses, and communities nationwide. With advanced degrees from Valparaiso University and Kent State University, Dr. Mata founded BrightSpot Families and partnered with the Anxiety Treatment Center of Greater Toledo. Her direct, relatable approach offers actionable strategies for navigating mental health challenges and creating lasting change. To know more about Andrea visit her website & socials: https://www.drdremata.com https://www.linkedin.com/in/drdremata/ https://www.youtube.com/@drdremata Podcast Sponsor: Summit Leadership Group Summit Leadership Group transforms organizations by developing bold, agile leaders who inspire performance and lead with purpose. Through tailored coaching and immersive training, we ignite lasting growth where it matters most—at the intersection of people, culture, and results. https://www.summitleadershipgroup.com/

Florida Gators quarterback DJ Lagway, the highly touted former five-star recruit and centerpiece of the Gators' offense, is currently dealing with a lower-body injury sustained ahead of fall camp. Seen wearing a walking boot, Lagway's injury has been described by team insiders as a minor calf strain, and he's expected to be fully ready for the 2025 season. As Florida eyes a bounce-back year under Billy Napier, Lagway's health remains critical to offensive success. Meanwhile, Florida's 2025 defensive line is shaping up as one of the SEC's most formidable units. Anchored by veteran stars like Caleb Banks and Tyreak Sapp—both with NFL aspirations—the line blends size, explosiveness, and disruptive ability across the front. Sophomore standout LJ McCray brings elite pass-rushing potential, while rotational depth from George Gumbs Jr. and new arrival Mbatchou bolsters the unit's versatility. Under the aggressive 4–2–5 scheme led by rising defensive coordinator Austin Armstrong, the Gators' D-line looks poised to be a game-changing force. Statistically, Florida's defense made major strides in 2024, including a +17 increase in sacks and +18 in total turnovers gained. The returning personnel and emerging talent position the 2025 line to be among the best in the SEC, with national analysts ranking it just behind powerhouses like Alabama and Oklahoma. With DJ Lagway expected back soon and the defensive front projected to dominate, Florida fans have every reason to be optimistic heading into the 2025 season.

What happens when you mix statistics with orgasms? You get this deliciously naughty episode! I'm reacting to a new survey about how often we're all getting off—and let's just say I have thoughts.

Coming out of the All-Star break, this team is 4-5. There might be more life than we gave them credit for. That Phillies series was rough. When was the last time you saw a walk off catcher's interference? Statistically, not in our lifetime. Ian misses Kyle Scwharber, the one that got away. Imagine what life would be like if we got 50 bonks out of Kyle Schwarber in Boston every year. It would be magical. But to take 2/3 from the Dodgers? We have never been so back. Pitching good, batting good, grit good. Garrett Crochet wheels DEI hire Clayton Kershaw out of the building. Also, Bregman is back. The trade deadline is Thursday. We tell you what we want. It's like Christmas (or Hannukkah, or Kwanzaa, or Diwali, or Yule, or Bodhi Day, or Guru Gobind Singh Jayanti, or Shogatsu, or...). Linktree NASP Instagram NASP Twitter Ian's Twitter Jack's Twitter

Surfshark's study reports that Ireland's data breaches increased by 70% in Q2 compared to Q1 2025 (87k vs. 51.1k), meaning over 100 thousand accounts were compromised in Ireland during the first half of the year. Globally, the latest data shows a 34% increase from 70 million to 94 million leaked accounts. The United States, France, India, Germany, and Israel were the countries most affected by breaches in Q2 2025. "Today's digital age requires all of us to share more and more personal information to carry out daily tasks. Whether sharing your name and address for food deliveries, or phone numbers when making a booking at a barber shop, there is no guarantee that businesses are keeping crucial information safe and secure. In the wrong hands, this data can be used to commit identity theft, via social media, for targeted scams or sold on the dark web - where they're traded for further illegal use." says Sarunas Sereika, Product Manager at Surfshark. An upward trend in breached Irish accounts is observed in Q2 2025, where data breaches increased by 70% compared to the previous quarter. Ireland ranks 38th globally with 87 thousand breached accounts (previously 51k in Q1 2025). Data breach statistics over the years Surfshark's analysis of data breaches since 2004 shows Ireland is the 4th in Northern Europe, with 27.3M compromised user accounts. A total of 6.5M unique emails were breached from Ireland. Statistically, the average Irish has been affected by data breaches around 5 times. 18.4M passwords were leaked together with Irish accounts, putting 67% of breached users in danger of account take over that might lead to identity theft, extortion or other cybercrimes. Ireland's full profile in the Global Data Breach Monitoring project can be found here: https://surfshark.com/research/data-breach-monitoring?country=ie Which countries have been the most affected in Q2 2025? In descending order, the ten most breached countries in Q2 2025 were the US (42.5M), France (11.4M), India (1.7M), Germany (1.3M), Israel (1.2M), Canada (968.6k), the UK (944k), Thailand (889.1k), Brazil (639.6k), and China (578.3k). The countries with the highest breach density over Q2 2025 (number of leaked accounts per 1,000 residents): France (172), Israel (130), the US (123), Singapore (26), Canada (24), South Sudan (23), Belgium (21), Ireland (16), Switzerland (16) and Germany (15). METHODOLOGY A data breach happens when confidential and sensitive data gets exposed to unauthorised third parties. In this study, we treat every breached or leaked email address used to register for online services as a separate user account, which may have been leaked with additional information, such as password, phone number, IP address, eircode, and more. The data was collected by our independent partners from 29,000 publicly available databases and aggregated by email address. This data was then anonymised and passed on to Surfshark's researchers to analyse their findings statistically. Countries with a population of less than 1M people were not included in the analysis. The Data Breach World Map is updated quarterly with the most recent data from our independent partners. For the full methodology, please refer to: https://surfshark.com/research/data-breach-monitoring/methodology See more stories here. More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page here: https://anchor.fm/irish-tech-news If you'd like to be featured in an upcoming Podcast email us at Simon@IrishTechNews.ie now to discuss. Irish Tech News have a range of services available to help promote your business. Why not drop us a line at Info@IrishTechNews.ie now to find out more about how we can help you reach our audience. You can also find and follow us on Twitter, LinkedIn, Facebook, Instagram, TikTok and Snapchat.

Angel Studios https://Angel.com/ToddJoin the Angel Guild today and stream Testament, a powerful new series featuring the retelling of the book of Acts. Alan's Soaps https://www.AlansArtisanSoaps.comUse coupon code TODD to save an additional 10% off the bundle price.Bioptimizers https://Bioptimizers.com/toddEnter promo code TODD to get 10% off your order of Berberine Breakthrough today.Bizable https://GoBizable.comUntie your business exposure from your personal exposure with BiZABLE.  Schedule your FREE consultation at GoBizAble.com today.  Bonefrog https://BonefrogCoffee.com/toddThe new GOLDEN AGE is here!  Use code TODD at checkout to receive 10% off your first purchase and 15% on subscriptions.Bulwark Capital https://KnowYourRiskPodcast.comHear directly from Zach Abraham as he shares insights in this FREE “Halftime” Webinar, THIS Thursday, July 24th at 3:30 Pacific.  Register now at Know Your Risk Podcast dot com. Renue Healthcare https://Renue.Healthcare/ToddYour journey to a better life starts at Renue Healthcare. Visit https://Renue.Healthcare/ToddLISTEN and SUBSCRIBE at:The Todd Herman Show - Podcast - Apple PodcastsThe Todd Herman Show | Podcast on SpotifyWATCH and SUBSCRIBE at: Todd Herman - The Todd Herman Show - YouTubeRussia Hoax: The Neurological Crime. // Journalism's Illness In One Tweet. // Andrew Tate was right to become a Muslim.  Episode   Links:President Trump accused President Obama of committing treason earlier today. That's not an insignificant thing…Obama can claim all day long that he didn't push the fake Russia Hoax, but apparently he's not aware of the existence of the internet, which makes it possible for everyone to go back and watch him do it with their own eyes:"Nobody ever said 'the Russians hacked the election!'" - Except, of course, they ALL said "the Russians hacked the election"CNN's Jake Tapper Joins Russia Hoax Declassification FirefightAfter the 2016 election, John McCain, Lindsey Graham, and Amy Klobuchar traveled to Ukraine together. After the trip they held a press conference and declared that Russia attacked the USA by hacking the 2016 election. It was all lies“Monogamy is not natural for men.  Statistically only 20-30% of men have ever reproduced, while 80-90% of women have reproduced…” 

HT2328 - Thoroughly Ironic Pixels I don't see how anyone could disagree with the notion that we are seeing more small images than ever before. Statistically speaking, I'll bet most images you see these days are smaller than 8x10" because most of them you've seen on your phone, your tablet, or your laptop. And this is in the age of ever increasing megapixel cameras. My new camera, for example, has a 200 megapixel sensor ,um, in my phone! Really? Show your appreciation for our free weekly Podcast and our free daily Here's a Thought… with a donation Thanks!

My husband Tim joins me for this honest, refreshing, and hope-filled conversation with Brian and Emilie McCormack. Together they lead Breakaway Ministries along with their 5 kids out of College Station. Whether you're an Aggie or just want to hear some incredible news of what's going on at one of the biggest college campuses in the US, the McCormacks give us a unique perspective of revival and discipleship taking place at Texas A & M. This one hits close to home for us, and today you'll hear a little about how this ministry has had a direct impact on our family. Today we pick up with Brian sharing the history and timeline of how Breakaway got started…Social media handle: @brianmccormack, @emiliemccormack, @breakawaymin Breakaway MinistriesShow Notes/Quotes:“When we're asked, 'What do we see?' The answer's always the same, it's just that we see hunger. There's a wild hunger among this generation and among college students right now.” “The opportunity is incredible, but the need and the urgency is just as big.”“And she said - ‘I don't know what happened, but I encountered God, and something in me changed.'”“It's God who's doing the heavy lifting, we just get to plant the seeds and then, man, sometimes we get to see the fruit.”“Statistically most people are deciding are they in or are they out when it comes to following Jesus in this 18-24 year old range.” “When I tell a couple thousand 20-year-olds, 'You are God's primary delivery mechanism for the grace and hope and healing of God in this day and age and there is no plan B', they kinda straighten up and are like, ‘Ok, what are we gonna do about that?'”“Two words come to mind - questions, and confession.” “I think the best thing a man can do is give his son a category for a man who is fully known by a few other men, and who are seeking God together.”Reflections on seminary, “I feel more certain that Jesus is the hope of the world, and I feel like I know less than I started.”“You have to have the living Word pouring into you.”“It's not just about information, but rather about transformation, and that transformation happens in God's nearness…proximity is the remedy.” 

Welcome or welcome back to Authentically ADHD, the podcast where we embrace the chaos and magic of the ADHD brain. Im carmen and today we're diving into a topic that's as complex as my filing system (which is to say, very): ADHD and its common co-occurring mood and learning disorders. Fasten your seatbelts (and if you're like me, try not to get distracted by the shiny window view) – we're talking anxiety, depression, OCD, dyslexia, dyscalculia, and bipolar disorder, all hanging out with ADHD.Why cover this? Because ADHD rarely rides solo. In fact, research compiled by Dr. Russell Barkley finds that over 80% of children and adults with ADHD have at least one other psychiatric disorder, and more than half have two or more coexisting conditions. Two-thirds of folks with ADHD have at least one coexisting condition, and often the classic ADHD symptoms (you know, fidgeting, daydreaming, “Did I leave the stove on?” moments) can overshadow those other disorders. It's like ADHD is the friend who talks so loud at the party that you don't notice the quieter buddies (like anxiety or dyslexia) tagging along in the background.But we're going to notice them today. With a blend of humor, sass, and solid neuroscience (yes, we can be funny and scientific – ask me how I know!), we'll explore how each of these conditions shows up alongside ADHD. We'll talk about how they can be misdiagnosed or missed entirely, and—most importantly—we'll dish out strategies to tell them apart and tackle both. Knowledge is power and self-awareness is the key, especially when it comes to untangling ADHD's web of quirks and comrades in chaos. So, let's get into it!ADHD and Anxiety: Double Trouble in OverdriveLet's start with anxiety, ADHD's frequent (and frantic) companion. Ever had your brain ping-pong between “I can't focus on this work” and “I'm so worried I'll mess it up”? That's ADHD and anxiety playing tango in your head. It's a double whammy: ADHD makes it hard to concentrate, and anxiety cranks up the worry about consequences. As one study notes, about 2 in 5 children with ADHD have significant problems with anxiety, and over half of adults with ADHD do as well. In other words, if you have ADHD and feel like a nervous wreck half the time, you're not alone – you're in very good (and jittery) company.ADHD and anxiety can look a lot alike on the surface. Both can make you restless, unfocused, and irritable. I mean, is it ADHD distractibility or am I just too busy worrying about everything to pay attention? (Hint: it can be both.) Especially for women, ADHD is often overlooked and mislabeled as anxiety. Picture a girl who can't concentrate in class: if she's constantly daydreaming and fidgety, one teacher calls it ADHD. Another sees a quiet, overwhelmed student and calls it anxiety. Same behavior, different labels. Women in particular have had their ADHD misdiagnosed as anxiety or mood issues for years, partly because anxious females tend to internalize symptoms (less hyperactive, more “worrier”), and that masks the ADHD beneath.So how do we tell ADHD and anxiety apart? One clue is where the distraction comes from. ADHD is like having 100 TV channels in your brain and someone else is holding the remote – your attention just flips on its own. Anxiety, on the other hand, is like one channel stuck on a horror movie; you can't focus on other things because a worry (or ten) is running on repeat. An adult with ADHD might forget a work deadline because, well, ADHD. An adult with anxiety might miss the deadline because they were paralyzed worrying about being perfect. Both end up missing the deadline (relatable – ask me how I know), but for different reasons.Neuroscience is starting to unravel this knot. There's evidence of a genetic link between ADHD and anxiety – the two often run in the family together. In brain studies, both conditions involve irregularities in the prefrontal cortex (the brain's command center for focus and planning) and the limbic system (emotion center). Essentially, if your brain were a car, ADHD means the brakes (inhibition) are a bit loose, and anxiety means the alarm system is hyper-sensitive. Combine loose brakes with a blaring alarm and you get… well, us. Fun times, right?Here's an interesting tidbit: Females with ADHD are more likely to report anxiety than males. Some experts think this is partly due to underdiagnosed ADHD – many girls grew up being told they were just “worrywarts” when in fact ADHD was lurking underneath, making everyday life more overwhelming and thus feeding anxiety. As Dr. Thomas Brown (a top ADHD expert) points out, emotional regulation difficulties (like chronic stress or worry) are characteristic of ADHD, even though they're not in the official DSM checklist. Our ADHD brains can amplify emotions – so a normal worry for someone else becomes a five-alarm fire for us.Now, action time: How do we manage this dynamic duo? The first step is getting the right diagnosis. A clinician should untangle whether symptoms like trouble concentrating are from anxiety, ADHD, or both. They might ask: Have you always had concentration issues (pointing to ADHD), or did they start when your anxiety kicked into high gear? Also, consider context – ADHD symptoms occur in most settings (school, work, home), while pure anxiety might spike in specific situations (say, social anxiety in crowds, or panic attacks only under stress).Treatment has to tackle both. Therapy – especially Cognitive Behavioral Therapy (CBT) – is a rockstar here. CBT can teach you skills to manage worry (hello, deep breathing and logical rebuttals to “what if” thoughts) and also help with ADHD organization hacks (like breaking tasks down, creating routines). Many find that medication is needed for one or both conditions. Stimulant meds (like methylphenidate or amphetamines) treat ADHD, but in someone with severe anxiety, a stimulant alone can sometimes ramp up the jitters. In fact, children (and adults) with ADHD + anxiety often don't respond as well to ADHD meds unless the anxiety is also addressed. Doctors might add an SSRI or other anti-anxiety medication to the mix, or choose a non-stimulant ADHD med if stimulants prove too anxiety-provoking.Let me share a quick personal strategy (with a dash of humor): I have ADHD and anxiety, so my brain is basically an internet browser with 50 tabs open – and 10 of them are frozen on a spinning “wheel of doom” (those are the anxieties). One practical tip that helps me distinguish the two is to write down my racing thoughts. If I see worries like “I'll probably get fired for sending that email typo” dominating the page, I know anxiety is flaring. If the page is blank because I got distracted after one sentence... well, hello ADHD! This silly little exercise helps me decide: do I need to do some calming techniques, or do I need to buckle down and use an ADHD strategy like the Pomodoro method? Try it out: Knowledge is power, and self-awareness is the key.Quick Tips – ADHD vs Anxiety: When in doubt, ask what's driving the chaos.* Content of Thoughts: Racing mind full of specific worries (anxiety) vs. racing mind full of everything except what you want to focus on (ADHD).* Physical Symptoms: Anxiety often brings friends like sweaty palms, racing heart, and tummy trouble. ADHD's restlessness isn't usually accompanied by fear, just boredom or impulsivity.* Treatment Approaches: For co-occurring cases, consider therapy and possibly a combo of medications. Experts often treat the most impairing symptom first – if panic attacks keep you homebound, address that alongside ADHD. Conversely, untreated ADHD can actually fuel anxiety (ever notice how missing deadlines and forgetfulness make you more anxious? Ask me how I know!). A balanced plan might be, say, stimulant medication + talk therapy for anxiety, or an SSRI combined with ADHD coaching. Work closely with a professional to fine-tune this.Alright, take a breath (seriously, if you've been holding it – breathing is good!). We've tackled anxiety; now let's talk about the dark cloud that can sometimes follow ADHD: depression.ADHD and Depression: When the Chaos Brings a CloudADHD is often associated with being energetic, spontaneous, even optimistic (“Sure, I can start a new project at 2 AM!”). So why do so many of us also struggle with depression? The reality is, living with unmanaged ADHD can be tough. Imagine years of what Dr. Russell Barkley calls “developmental delay” in executive function – always feeling one step behind in managing life, despite trying so hard. It's no surprise that about 1 in 5 kids with ADHD also has a diagnosable depression, and studies show anywhere from 8% to 55% of adults with ADHD have experienced a depressive disorder in their lifetime. (Yes, that range is huge – it depends how you define “depression” – but even on the low end it's a lot.) Dr. Barkley himself notes that roughly 25% of people with ADHD will develop significant depression by adulthood. In short, ADHD can come with a case of the blues (not the fun rhythm-and-blues kind, unfortunately).So what does ADHD + depression look like? Picture this: You've got a pile of unfinished projects, bills, laundry – the ADHD “trail of crumbs.” Initially, you shrug it off or maybe crack a joke (“organizational skills, who's she?”). But over time, the failures and frustrations can chip away at your self-esteem. You start feeling helpless or hopeless: “Why bother trying if I'm just going to screw it up or forget again?” That right there is the voice of depression sneaking in. ADHD's impulsivity might also lead to regrettable decisions or conflicts that you later brood over, another pathway to depressed mood.In fact, the Attention Deficit Disorder Association points out that ADHD's impact on our lives – trouble with self-esteem, work or school difficulties, and strained relationships – can contribute to depression. It's like a one-two punch: ADHD creates problems; those problems make you sad or defeated, which then makes it even harder to deal with ADHD. Fun cycle, huh?Now, depression itself can mask as ADHD in some cases, especially in adults. Poor concentration, low motivation, fatigue, social withdrawal – these can appear in major depression and look a lot like ADHD symptoms. If an adult walks into a doctor's office saying “I can't focus and I'm procrastinating a ton,” a cursory eval might yield an ADHD diagnosis. But if that focus problem started only after they, say, lost a loved one or fell into a deep funk, and they also feel worthless or have big sleep/appetite changes, depression may be the primary culprit. On the flip side, a person with lifelong ADHD might be misdiagnosed as just depressed, because they seem down or overwhelmed. As always, timeline is key: ADHD usually starts early (childhood), whereas depression often has a more defined onset. Also, ask: Is the inability to focus present even when life's going okay? If yes, ADHD is likely in the mix. If the focus issues wax and wane with mood, depression might be the driver.There's also a nuance: ADHD mood issues vs. clinical depression. People with ADHD can have intense emotions and feel demoralized after a bad day, but often these feelings can lift if something positive happens (say, an exciting new interest appears – suddenly we have energy!). Clinical depression is more persistent – even good news might not cheer you up much. As Dr. Thomas Brown emphasizes, ADHD includes difficulty regulating emotion; an ADHD-er might feel sudden anger or sadness that's intense but then dissipates . By contrast, depression is a consistent low mood or loss of pleasure in things over weeks or months. Knowing this difference can be huge in sorting out what's going on.Now, how do we deal with this combo? The good news: many treatments for depression also help ADHD and vice versa. Therapy is a prime example. Cognitive Behavioral Therapy and related approaches can address negative thought patterns (“I'm just a failure”) and also help with practical skills for ADHD (like scheduling, or as I call it, tricking my brain into doing stuff on time). There are even specialized therapies for adults with ADHD that blend mood and attention strategies. On the medication front, sometimes a single med can pull double duty. One interesting option is bupropion (Wellbutrin) – an antidepressant that affects dopamine and norepinephrine, which can improve both depression and ADHD symptoms in some people. There's also evidence that stimulant medications plus an antidepressant can be a powerful combo: stimulants to improve concentration and energy, antidepressant to lift mood. Psychiatrists will tailor this to the individual – for instance, if someone is severely depressed (can't get out of bed), treating depression first may be priority. If the depression seems secondary to ADHD struggles, improving the ADHD could automatically boost mood. Often, it's a balancing act of treating both concurrently – maybe starting an antidepressant and an ADHD med around the same time, or ensuring therapy covers both bases.Let's not forget lifestyle: exercise, sleep, nutrition – these affect both ADHD and mood. Regular exercise, for example, can increase BDNF (a brain growth factor) and neurotransmitters that help both attention and mood. Personally, I found that when I (finally) started a simple exercise routine, my mood swings evened out a bit and my brain felt a tad less foggy. (Of course, starting that routine required overcoming my ADHD inertia – ask me how I know that took a few tries... or twenty.)Quick Tips – ADHD vs Depression:* Check Your Joy Meter: With ADHD alone, you can still feel happy/excited when something engaging happens (ADHD folks light up for interesting tasks!). With depression, even things you normally love barely register. If your favorite hobbies no longer spark any joy, that's a red flag for depression.* All in Your Head? ADHD negative thoughts sound like “Ugh, I forgot again, I need a better system.” Depression thoughts sound like “I forgot again because I'm useless and nothing will ever change.” Listen to that self-talk; depression is a sneaky bully.* Professional Help: A thorough evaluation can include psychological tests or questionnaires to measure attention and mood separately. For treatment, consider a combined approach: therapy (like CBT or coaching) plus meds as needed. According to research, a mix of stimulant medication and therapy (especially CBT) can help treat both conditions. And remember, addressing one can often relieve the other: improve your ADHD coping skills, and you might start seeing hope instead of disappointment (boosting mood); treat your depression, and suddenly you have the energy to tackle that ADHD to-do list.Before we move on, one more important note: if you ever have thoughts of self-harm or suicide, please reach out to a professional immediately. Depression is serious, and when compounded with ADHD impulsivity, it can be dangerous. There is help, and you're not alone – so many of us have been in that dark place, and it can get better with the right support. Knowledge is power and self-awareness is the key, yes, but sometimes you also need a good therapist, maybe a support group, and possibly medication to truly turn things around. There's no shame in that game.Alright, deep breath. It's getting a bit heavy in here, so let's pivot to something different: a condition that seems like the opposite of ADHD in some ways, yet can co-occur – OCD. And don't worry, we'll crank the sass back up a notch.ADHD and OCD: The Odd Couple of AttentionWhen you think of Obsessive-Compulsive Disorder (OCD), you might picture someone extremely organized, checking the stove 10 times, everything neat and controlled. When you think ADHD… well, “organized” isn't the first word that comes to mind, right?

Jacoby Landry, the new owner of Lafayette's oldest indoor shopping center, Northgate Mall, shares his vision to bring hope, commerce, and fresh energy to North Lafayette. Jacoby's energy and can-do attitude is a beacon of light for a community waiting to see how he will transform the mall into "The Hub." Jacoby, owner of JL Construction and Pont Breaux Plaza in Breaux Bridge, is the first local owner of Northgate Mall in years. Originally developed by Isan Fontenot, Dr. Daniel Voorheis and Joseph Angelle who opened it in August 1969, Jacoby paid $2.8 million for the property. His journey started under the wing of his grandfather, a framer, and his father, who ran dirt construction, trucking businesses, and in the oil field industry. “My entrepreneurial skills came from my dad. He's always been a business owner.” After studying engineering at UL Lafayette, Jacoby discovered his love for business and numbers, opening a tax office in his early twenties. Real estate soon became his passion, with his first major commercial property purchased from cousin Dominick Williams (formerly Dominick Davis of LSU and the Houston Texans). “There's nothing that I didn't try,” Jacoby shared, reflecting on his entrepreneurial spirit. In 2016, Jacoby earned his residential contractor's license, followed by obtaining his commercial license a year later. “I went from building custom homes to developing my own lots and building spec homes and selling them.” His interest in North Lafayette grew when he purchased seven acres on Louisiana Avenue at Butcher Switch Road in 2020 with plans for a med spa and gym. Facing zoning challenges, Jacoby joined LEDA's Elevate North Lafayette program, where he connected with Monte Anderson, a Dallas-based developer. Monte's advice led Jacoby to consider revitalizing existing properties, prompting Jacoby to set his sights on Northgate Mall. "I was always infatuated with the I-10 and I-49 crossing. I just always had it in my mind that it (development) was going to come to the North one day." “Before I started the program, I had goals of doing something bigger, but they really pushed me to actually go do it. They gave me the courage and knowledge to do it.” Once Jacoby walked the property, he couldn't sleep at night thinking about its potential. “Ever since the day I walked on the property, I couldn't sleep at night, thinking about it. I think I want to do it.” Despite initial nerves, Jacoby embraced the risk, saying, “I'm a risk taker. I could do this.” Jacoby Landry at the Northgate Mall in June 2025. Photo by Brad Kemp, Acadiana Advocate. Jacoby is rebranding Northgate Mall as “The Hub,” inspired by Lafayette's nickname, Hub City, and the I-10/I-49 cloverleaf, which will be reflected in its new logo. The redevelopment will focus on mixed-use commerce, green spaces, and lighting to ensure safety and create a welcoming atmosphere. “I want to change the whole theme of the mall. I want to have trees, green space, make it nice, have a lot of lighting and make it feel safe.” Contrary to negative perceptions, Jacoby says, “Statistically, there's no crime at the mall. There's more crime in other places. The mall's been dead for so long, there's nothing to steal.” Jacoby's vision includes a grocery store, children's entertainment options, and a health club and spa in the former Planet Fitness space in partnership with his sister, Rachel McCorvey of BeLuxxe Health and Wellness Center. “Our whole motto is to add ten years to your life.” The facility will feature a nutritionist, weight management services, Botox, IV drips, sauna, hot tub, salt room, cold plunge, a health bar, and two indoor pickleball courts. Pilates and boxing fitness will also be offered, bringing Red's Health Club-like amenities to North Lafayette on a smaller, community-focused scale. Jacoby emphasized his commitment to supporting current tenants, saying, “They've been a blessing… I came to introduce myself to ...

12 core reasons why you can trust that the Bible is God'sWord to us. Do you know these 12? Memorize these because you can use them toshare the gospel with unbelievers and doubters. Reason #6 of 12.here are bullet points on why the fulfillment of over 300 prophecies by Jesus is so powerful:Statistically impossible: The odds of one person fulfilling even a handful of specific ancient prophecies is astronomical, let alone 300+.Written centuries before: These prophecies were recorded hundreds of years before Jesus was born, proving they weren't staged after the fact.Details impossible to control: Many prophecies (like His birthplace, manner of death, betrayal price) were beyond Jesus's human control.Confirms divine plan: Shows God's sovereignty in orchestrating history to point to the Messiah.Strengthens faith: Fulfilling so many specific predictions validates that Jesus is truly the promised Savior.

Attention: The first clinical trial testing creatine for Alzheimer's just dropped, and the results are absolutely mind-blowing. In this episode, I've sat down with Max Lugavere at The White House to discuss the new research on creatine. This pilot study gave 20 Alzheimer's patients 20 grams of creatine daily for 8 weeks. The results? Statistically significant improvements across nearly every cognitive measurement.  Join the Ultimate Human VIP community and gain exclusive access to Gary Brecka's proven wellness protocols today!: https://bit.ly/4ai0Xwg Get Max Lugavere book, “Genius Foods”: https://theultimatehuman.com/book-recs Want to dive deeper into brain health? Watch Max's documentary "Little Empty Boxes" here: https://bit.ly/47Qf8Y9 Listen to Max Lugavere's "The Genius Life" podcast weekly on all your favorite platforms: https://bit.ly/47MyoWK Connect with Max Lugavere: Website: https://bit.ly/3XLOGdN YouTube: https://bit.ly/4eJc6r7 Instagram: https://bit.ly/3BsEf7y Facebook: https://bit.ly/3Y4QkZr TikTok: https://bit.ly/3Y8ov2w X.com: https://bit.ly/3ZMQgPk LinkedIn: https://bit.ly/4eGVrEw Thank you to our partners: H2TABS - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH - USE CODE “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD - USE CODE "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP - SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E COLD LIFE - THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP - GET 1 FREE MONTH WHEN YOU JOIN!: https://bit.ly/3VQ0nzW MASA CHIPS - GET 20% OFF YOUR FIRST ORDER: https://bit.ly/40LVY4y VANDY - USE CODE “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE AION - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD HAPBEE - FEEL BETTER & PERFORM AT YOUR BEST: https://bit.ly/4a6glfo CARAWAY - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF - GET 10% OFF YOUR ORDER: https://bit.ly/41HJg6S BIOPTIMIZERS - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/4inFfd7 RHO NUTRITION - USE CODE “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GENETIC TEST: ⁠https://bit.ly/3Yg1Uk9 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka: Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X.com: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps: 00:00 Intro 01:30 Getting Back to the Basics 02:17 Clinical Trial on Creatine  05:57 Impact of Creatine on Health 11:26 Spreading Awareness on Positive Healthcare Choices The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

We've got plenty to catch up on this week — from the Pan American Championships and Asian Championships to college gymnastics news. It's been a while, and we're long overdue for a sit-down. But before we dive into all that, we've got another interview lined up! We're excited to continue our Recruit Reflection series with UNC standout JoJo Valahovic, who just wrapped up her freshman season with the Tar Heels as the ACC Newcomer of the Year. In many ways, JoJo was a breakout star this season. Statistically, she was the team MVP on vault and beam in total points contributed — and she was only a freshman! JoJo joins us to talk about her recruiting journey and what led her to UNC! Thank you to our monthly Patreon supporters: Lee B, Cookiemaster, Christa, Happy Girl, Erica S, Semflam, Amy C, Maria L, Becca S, Cathleen R, Faith, Kerry M, M, Derek H, Martin, Sharon B, Randee B, MSU, Kimberly G, Robert H, Lela M, Mara L, Jenna A, Alex M, Mama T, Kelsey, Lidia, Maria P, Alicia O, Cristina K, Bethany J, Diane J, Kentiemac, Marni S, Betny T, Emily C, Cathy D, Lisa T, Libby C, Thiago, Taryn M, Dana B, Jamie S, Chuck C, Je_GL, Kaitlin, Susan P, Katertot, Mallory D, LFC_Hokie, Ella, Debbie, Megan F, Kay, Diane J, Julie B,, Austin K, Jane, Sarah, Amy, Stephen S, Johanna T, Alison S, Kristina T, Abigail W, Becky, Ola S, Jennifer K, Kate M, Naomi S, Claudia, Siona, Erin L, Sarah A, Kennedy B, Thomas B, Lauren D, Kihika N, Beth C, Amy, Renee PM, Ryan V, Brandon H, Tyler, Hayley B, Ben S, Kate & Landon, Danielle, ALittleUnderRotated, Dana C, Amy C, Grace, Pat G , Lexi G, Laura N, Kathy, Katie A, Ruby B, Katie E, Róisín, Becca, Megan J, Emily D, Britton, Ry Shep, Reyna G, Catherine, William A, MB, MJ L, Jackson G, Brittany A, Stella, Ulo F, Noah C, Melissa H, Alexis, William M, Trish, Susie, Leslie G, Catherine B, Karlin, Laura L, Katy S, J'nia G, Kathy M, Kathy S, Okcaro, Caroline P, JD B, Cookiecutter, Ailish D, Wil D & BC

0:00 - With the Panthers winning the Stanley Cup last night, Canada's cup drought continues. They haven't brought Lord Stanley north of the border since 1993. That's WILD. Statistically, that seems pretty improbable.14:08 - Every year after the Stanley Cup Finals wrap up, players on both teams rattle off a laundry list of injuries they've been playing with. It's always way more guys than you'd expect playing through worse injuries than you'd expect. Matthew Tkachuk wins the Grit award this year.33:03 - Broncos chose to bolster their defense this offseason more so than their offense. But there's a method to Sean Payton's madness.

Austin shares how you can statistically guarantee that you get a job offer with the “Funnel Technique”!Time Stamped Show Notes:[0:20] - A guaranteed job offer?[2:11] - Map out your job search process & track it[3:20] - Assign success rates & reverse engineer your funnel[5:36] - Gather data & OptimizeWant To Level Up Your Job Search?Click here to learn more about 1:1 career coaching to help you land your dream job without applying online.Check out Austin's courses and, as a thank you for listening to the show, use the code PODCAST to get 5% off any digital course:The Interview Preparation System - Austin's proven, all-in-one process for turning your next job interview into a job offer.Value Validation Project Starter Kit - Everything you need to create a job-winning VVP that will blow hiring managers away and set you apart from the competition.No Experience, No Problem - Austin's proven framework for building the skills and experience you need to break into a new industry (even if you have *zero* experience right now).Try Austin's Job Search ToolsResyBuild.io - Build a beautiful, job-winning resume in minutes.ResyMatch.io - Score your resume vs. your target job description and get feedback.ResyBullet.io - Learn how to write attention grabbing resume bullets.Mailscoop.io - Find anyone's professional email in seconds.Connect with Austin for daily job search content:Cultivated CultureLinkedInTwitterThanks for listening!

Trevor, Hunter, and Konner keep you up to date on everything going on in disc golf! Subscribe ► https://youtube.com/@GripLocked?sub_confirmation=1 Check out the Store: http://foundationdiscs.com Patreon: http://patreon.com/foundationdiscgolf Foundation Disc Golf: http://youtube.com/foundationdiscgolf 0:00 - Intro 3:30 - Preserve Recap 34:41 - Trevor's Trivia 44:05 - Manufacturer's Cup 46:40 - Pick Em vs Tour Life 52:50 - Top 10 57:06 - Silas Selects

My conversation with Matthew Walker, PhD on faculty at UC Berkeley where he is a professor of neuroscience and psychology, the founder and director of the Center for Human Sleep Science, and has a long history of seminal contributions on sleep science and health. Audio File (also downloadable at Apple Podcast and Spotify)“Sleep is a non-negotiablebiological state required for the maintenance of human life . . . our needsfor sleep parallel those for air, food, and water.”—Grandner and FernandezEric Topol (00:07):Hello, it's Eric Topol with Ground Truths, and I am really delighted to welcome Matt Walker, who I believe has had more impact on sleep health than anyone I know. It's reflected by the fact that he is a Professor at UC Berkeley, heads up the center that he originated for Human Sleep Science. He wrote a remarkable book back in 2017, Why We Sleep, and also we'll link to that as well as the TED Talk of 2019. Sleep is Your Superpower with 24 million views. That's a lot of views here.Matt Walker:Striking, isn't it?Eric Topol:Wow. I think does reflect the kind of impact, you were onto the sleep story sooner, earlier than anyone I know. And what I wanted to do today was get to the updates because you taught us a lot back then and a lot of things have been happening in these years since. You're on it, of course, I think you have a podcast Sleep Diplomat, and you're obviously continued working on the science of sleep. But maybe the first thing I'd ask you about is in the last few years, what do you think has been, are there been any real changes or breakthroughs in the field?What Is New?Matt Walker (01:27):Yeah, I think there has been changes, and maybe we'll speak about one of them, which is the emergence of this brain cleansing system called the glymphatic system, but spreading that aside for potential future discussion. I would say that there are maybe at least two fascinating areas. The first is the broader impact of sleep on much more complex human social interactions. We think of sleep at maybe the level of the cell or systems or whole scale biology or even the entire organism. We forget that a lack of sleep, or at least the evidence suggests a lack of sleep will dislocate each other, one from the other. And there's been some great work by Dr. Eti Ben Simon for example, demonstrating that when you are sleep deprived, you become more asocial. So you basically become socially repellent. You want to withdraw, you become lonely. And what's also fascinating is that other people, even they don't know that you sleep deprived, they rate you as being less socially sort of attractive to engage with.Matt Walker (02:35):And after interacting with you, the sleep deprived individual, even though they don't know you're sleep deprived, they themselves walk away feeling more lonely themselves. So there is a social loneliness contagion that happens that a sleep deprived lonely individual can have almost a viral knock on effect that causes loneliness in another well-rested individual. And then that work spanned out and it started to demonstrate that another impact of a lack of sleep socially is that we stop wanting to help other people. And you think, well, helping behavior that's not really very impactful. Try to tell me of any major civilization that has not risen up through human cooperation and helping. There just isn't one. Human cooperative behavior is one of our innate traits as homo sapiens. And what they discovered is that when you are insufficiently slept, firstly, you don't wish to help other people. And you can see that at the individual level.Matt Walker (03:41):You can see it in groups. And then there was a great study again by Dr. Eti Ben Simon that demonstrated this at a national level because what she did was she looked at this wonderful manipulation of one hour of sleep that happens twice a year to 1.6 billion people. It's called daylight savings time at spring. Yeah, when you lose one hour of sleep opportunity. She looked at donations across the nation and sure enough, there was this big dent in donation giving in the sleepy Monday and Tuesday after the clock change. Because of that sleep, we become less willing to empathetically and selflessly help other individuals. And so, to me I think it's just a fascinating area. And then the other area I think is great, and I'm sorry I'm racing forward because I get so excited. But this work now looking at what we call genetic short sleepers and sort of idiots like me have been out there touting the importance of somewhere between seven to nine hours of sleep.Matt Walker (04:48):And once you get less than that, and we'll perhaps speak about that, you can see biological changes. But there is a subset of individuals who, and we've identified at least two different genes. One of them is what we call the DEC2 gene. And it seems to allow individuals to sleep about five hours, maybe even a little bit less and show no impairment whatsoever. Now we haven't tracked these individuals across the lifespan to truly understand does it lead to a higher mortality risk. But so far, they don't implode like you perhaps or I would do when you are limited to this anemic diet of five hours of sleep. They hang in there just fine. And I think philosophically what that tells me, and by the way, for people who are listening thinking, gosh, I think I'm probably one of those people. Statistically, I think you are more likely to be struck by lightning in your lifetime than you are to have the DEC2 gene. Think about what tells us, Eric. It tells us that there is a moment in biology in the evolution of this thing called the sleep physiological need that has changed such that mother nature has found a genetic way to ZIP file sleep.Matt Walker (06:14):You can essentially compress sleep from seven to nine hour need, down to five to six hour need. To me, that is absolutely fascinating. So now the race is on, what are the mechanisms that control this? How do we understand them? I'm sure much to my chagrin, society would like to then say, okay, is there a pill that I can take to basically ZIP file my own sleep and then it becomes an arms race in my mind, which is then all of a sudden six hours becomes the new eight hours and then everyone is saying, well, six hours is my need. Well I'll go to four hours and then it's this arms race of de-escalation of sleep. Anyway, I'm going on and on, does that help give you a sense of two of the what I feel the more fascinating areas?Eric Topol (07:01):Absolutely. When I saw the other recent report on the short sleep gene variant and thought about what the potential of that would be with respect to potential drug development or could you imagine genome editing early in life that you don't need any sleep? I mean crazy stuff.Matt Walker (07:19):It was amazing.Glymphatics and Deep Sleepfor more, see previous Ground Truths on this topic Eric Topol (07:22):No, the mechanism of course we have to work out and also what you mentioned regarding the social and the behavior engagement, all that sort of thing, it was just fascinating stuff. Now we touched on one thing early on to come back to the glymphatics these channels to get rid of the waste metabolites from the brain each night that might be considered toxic metabolites. We've learned a lot about those and of course there's some controversy about it. What are your thoughts?Matt Walker (07:55):Yeah, I think there's really quite comprehensive evidence suggesting that the brain has this cleansing system like the body has one the lymphatic system, the brain has one the glymphatic system named after these glial cells that make it up. And I think there's been evidence from multiple groups across multiple different species types, from mouse models all the way up to human models suggesting that there is a state dependent control of the brain cleansing system, which is a fancy way of saying if you are awake in light NREM, deep NREM or perhaps you're just quiet and you are resting in your wakefulness, the glymphatic system is not switched on at the same rate across all of those different brain states. And I think the overwhelming evidence so far using different techniques in different species from different groups is that sleep is a preferential time. It's not an exclusive time, it's a preferential time when that brain cleansing system kicks into gear because as some people have, I think argued, and you could say it's hyperbolic, but wakefulness is low level from a biochemicals perspective, it's low level brain damage and sleep is therefore your sanitary salvation that combat that biochemical cascade.Matt Walker (09:15):So in other words, a better way of putting it would be, sleep is the price that you pay for wakefulness in some ways. And I think there was a recent controversial study that came out in 2022 or 2023, and they actually suggested quite the opposite. They said using their specific imaging methods, they found that the sort of clearance, the amount of cerebral spinal fluid, which is what washes through the brain to cleanse the toxins, the rate of that flow of cerebral spinal fluid was highest during wakefulness and lowest during deep NREM sleep, the exact opposite of what others have found. Now, I think the defendants of the glymphatic sleep dependent hypothesis pushed back and said, well, if you look at the imaging methods. Firstly, they're nonstandard. Secondly, they were measuring the cerebral spinal flow in an artificial way because they were actually perfusing solutions through the brain rather than naturally letting it flow and therefore the artificial forcing of fluid changed the prototypical result you would get.Matt Walker (10:27):And they also argued that the essentially kind of the sampling rate, so how quickly are you taking snapshots of the cerebral spinal fluid flow. Those were different and they were probably missing some of the sleep dependent slow oscillations that seemed to sort of drive that pulsatile flow. Honestly, I think that paper was still very well done, and I still think there is right now, I would still cleave to the majority of overwhelming evidence considering it's not just from one group in one species, but across multiple species, multiple groups. And I think it's nevertheless a weight of burden that has pushed back. And my sense right now, I used to think and cleaves to the notion that it was a sleep expressly selective process. Now I don't think that that's the case anymore. I think that the glymphatic system is a dynamic system, but it's always looking for the opportunity to go into cleansing mode. And you can kind of go into almost like a low battery mode when you are awake, but in quiet rest. And I think that can drive some already early clearance from the brain and then when you go into sleep, it's like powering your phone off entirely. It truly gets the chance to cleanse and reboot the biochemical system. But I think it's really interesting. I think there's a lot of work still yet to be done. It's not quite as case closed as we used to think.Eric Topol (12:03):Yeah, I mean first of all, it's great that you straighten out the controversy because that's exactly what I was referring to. And secondly, as you also pointed out, the weight of the evidence is that it's a sleep dependent phenomena, particularly during flow wave deep sleep is at least what I've seen.Matt Walker (12:21):Yes.Eric Topol (12:22):What's also interesting, your point about it being dynamic, which fascinating, there was a paper in my field of cardiology, people with atrial fibrillation had less active glymphatic, less clearance which was really interesting. And then the other finding that's also noteworthy was that Ambien made things worse. What do you think about that?We Are An Embodied OrganismMatt Walker (12:45):I think it's really interesting, and just to come back to your point about the AFib paper, what we know is that this cleansing system in the brain does seem to track the big slow brainwaves of deep slow wave sleep, but it's not only tracking the big slow brainwaves. If anything, there's something to do with the cardiorespiratory cycle, the respiration rate and the cardiac signal that may actually sink with the brainwaves. And it's essentially a cardiorespiratory neurophysiological coupling, which is a lot of ways, which is to say heart, lungs and brain coupled together. And it's the coupling of the cardiorespiratory slow oscillations that drive these pulsatile fluid mechanical, it's literally a hydro mechanical, hydro meaning cerebral spinal fluid push and pull in and out of the system drawing those metabolites out. So ago, if you have a disrupted either cardiac or respiratory or neurophysiological signal, no wonder the glymphatic system isn't going to work as efficiently.Matt Walker (14:00):I think that's a beautiful demonstration of the hemineglect that people like me who study sleep largely from the neck upwards would miss. But if you think about sleep is not just for the brain, it's for the body and it's not just for the body, it's for the brain. And we're an embodied organism. We study the organism in silos, neurology, psychiatry, cardiology, respiratory, but they all interact. And so, I think what's lovely about your example is the reminder that if you don't study the body in this study of the glymphatic system, you could miss out a profound explanation that possibly accounts for the head scratching, I don't know why we're getting this result. So that's a long way to come back to it. But the same group that was the pioneer in the discovery of the glymphatic system led by Maiken Nedergaard at the University of Rochester.In SUPER AGERS, p. 57. SRI-sleep regulatory indexSleep MedicationsMatt Walker (15:01):She has gone on to then look to say, well, if this is a sleep dependent process of brain cleansing during deep sleep, what about sleeping pills because so many people are either taking or are addicted to sleeping pills. And we've gone through, we're in the era of web 3.0 with sleeping pills, we started off web 1.0 which were the benzos, the kind of temazepam, diazepam, lorazepam. Then we went to web 2.0, which was sort of the Ambien (zolpidem), Lunesta, Sonata. And what was common about those two classes of drugs is that they both went after something called the GABA receptor in the brain, which is this major inhibitory receptor in the brain. And essentially, they were called sedative hypnotics because they sedated your cortex. And when you take an Ambien and not going to argue you're awake. You're clearly not awake, but to argue you're a naturalistic sleep, if you look at this, physiology is an equal fallacy.Matt Walker (16:01):They made this interesting experimental hypothesis that when you take Ambien, you sleep longer and based on how you score deep sleep, it would seem as though Ambien increases the amount of minutes that you spend in deep sleep. But if you look at the electrical signature during that “increased deep sleep” it's not the same. Ambien takes a big bite. There's a big dent out of the very slowest of the slow brainwaves, and it's the slowest of the slow brainwaves that drive the glymphatic system. So what they found was that when you take Ambien or you give mice Ambien. Yes, they sleep longer, they seem to have more deep sleep, but the brain cleansing mechanism seem to be reduced by anywhere between 30-40%, which is counterintuitive. If you are sleeping more and you're getting more deep sleep and the glymphatic system is active during deep sleep, you should get greater cleansing of the brain.Matt Walker (17:05):Here they found, yes, the drug increased sleep, particularly deep sleep, but it empowered the cleansing of the brain system. Now, have we got evidence of that in humans yet? No, we don't. I don't think it's far away though, because there was a counter study that brings us onto web 3.0. There's a new class of sleep medications. It's the first class of medications that have actually been publicly advocating for, they're called the DORAs drugs, and they are a class of drugs and there's three of them that are FDA approved right now. DORA stands for dual orexin receptor antagonists, which means that these drugs go in there and they block the action of a chemical called orexin. What is orexin? Orexin is the volume button for wakefulness. It dials at wakefulness, but these drugs come into your system and unlike the sedative sort of baseball bat to the cortex, which is Ambien, these drugs are much more elegant.Matt Walker (18:11):They go down towards the brainstem and they just dial down the volume on wakefulness and then they step back, and they allow the antithesis of wakefulness to come in its place, which is this thing called naturalistic sleep. And people sleep longer. So as a scientist, you and I perhaps skeptics would then say, well, so you increase sleep, and I have four words for you. Yes, and so what. Just because you increase sleep, it doesn't mean that it's functional sleep. It could just be like the old notion of junk DNA, that it's epiphenomenal sleep. It's not functional sleep. There was a study out of WashU and they took 85-year olds and above and they gave them one of these DORAs drugs. It's a drug called Belsomra, it's a play on good sleep or beautiful sleep, chemical named suvorexant and randomized placebo control. What they found is that when they took the drug, yes, these older adults slept longer, they had more deep sleep, but then what they did was clever. Before and after the night of sleep, they drew blood because we can now measure markers of β-amyloid and tau protein circulating in the bloodstream, which are these two markers of Alzheimer's disease.Matt Walker (19:28):Why is that relevant to the glymphatic system? It's relevant because two of the pieces of metabolic detritus that the cleansing system washes away at night, β-amyloid and tau. I'm sure enough of what they found was that not only did the adults sleep longer with these sleeping medications, they also had a greater clearance of β-amyloid and tau within the bloodstream. So this was the exact opposite of the Ambien study, which was where they were seeing an impairment in the glymphatic activity. Here in humans was a study with the web 3.0 sleep medications. Suvorexant, not only did it increase sleep, but it seemed to increase. Well, the assumption was that it was increasing glymphatic clearance because at least as the end outcome product, there was greater clearance of β-amyloid and tau protein in the blood. It wasn't just junk sleep, it was functional sleep. So for the first time I'd seen a sleeping medication that increased sleep more naturalistically, but that increased sleep made you the organism function better the next day as a consequence. Does that make any sense?Eric Topol (20:38):Absolutely. And it's interesting that we may have a sleep medicine finally or a class that actually is doing what is desired. This is one of the other things I was going to ask you about is that as you pointed out, this is an interaction throughout the organism, throughout the human being, and we've seen studies about how sleep disrupts metabolism and through that of course, and even separately, can take down our immune system or disrupt that as well. And so, one of the questions I guess is your thoughts about these other effects because you mentioned of course the potential of looking at things like p-Tau217 markers or other markers that would denote the status of your ultimate risk for moving on to Alzheimer's disease. But there's these other factors that also play a role with lack of adequate sleep and perhaps particularly sleep quality. I wonder if you could just comment about this because there's so many different systems of the body that are integrated here, and so the sanitary effect that you just described with the ability to potentially see less, at least biomarkers for what would be considered risks to ultimately develop Alzheimer's, there's also these other very important effects when we talk about high quality sleep, I guess, right? And maybe you could comment about that.Matt Walker (22:21):Yeah, I think quantity is what we've been talking about in some ways, but quality has also come onto the radar as absolutely essential. And what we find is that the quality of your sleep is as if not more predictive of both all-cause mortality, cardiovascular mortality, metabolic mortality, and in some regards, cancer mortality as well. And when I say quality of sleep, what we're really referring to here is at least one of two things. One is the continuity of your sleep. So you could be sleeping for eight and a half hours according to your sleep tracker, but maybe you are getting eight and a half hours by spending ten hours of time in bed because you are awake so much throughout the night and your sleep is very sort of punctured and littered with all of these awakenings across the night. That's sufficient quantity of sleep eight and a half hours, but it's poor quality of sleep because you are spending too much time awake.Matt Walker (23:30):And so, our measure of quality of sleep typically is what we call sleep efficiency. Of the time that you are in bed, what percent of that time are you asleep? And we like to see some measure of at least 85% or above because once you get less than 85% in terms of your sleep quality or your sleep efficiency, then you start to see many of these unfolding system-wide impairments. You seem to have high risk of diabetes, high risk obesity, high risk, as we said, cardiovascular disease. Also, hormonal changes both in men and in women. We see upstairs in the brain with poor quality of sleep, much more so than quantity of sleep. Poor quality of sleep is a more powerful predictor of mood disturbances and psychiatric conditions. And in fact, I think if you look at the data, at least in my center in the past 23 years, we've not been able to discover a single psychiatric condition in which sleep is normal, which to me is a stunning revelation. And what that tells us is that in many of those conditions they do seem to be getting not too bad of quantity of sleep. What is the marker of psychiatric sleep disturbance is not short quantity, it's poor quality of sleep. So I think it's a wonderful important point that I don't think we pay enough attention to, which is the quality.Eric Topol (25:05):Yes. And the other thing that you've emphasized, and I just want to reiterate to people listening or watching that is the regularity story, just like you said with quality. The data and I'll put the figure in that shows the link between regularity and cardiovascular, neurodegenerative, cancer, that regularity thing. A lot of people don't understand how important that is as well.Matt Walker (25:30):Stunning study from data from the UK Biobank, and this is across thousands and thousands of individuals and they tracked quantity and they tracked regularity and they split people up into the quartiles, those who were most regular and those who were least regular. And as you'll see in those sort of the figure that you flash up, those people who were in the upper quartile of regularity, de-risk all-cause mortality, cancer mortality, cardiovascular mortality, it was stunning. And then they did a cute little experiment of a statistical test where they took quantity because they had it in these individuals and regularity and they kind of put them in the same statistical bucket and did a sort of a Coke Pepsi challenge to see which one won out. And what it seemed to be was that regularity almost beat out quantity in terms of predicting all-cause mortality. Now that's not to say that you can get away with saying, well, I sleep four hours a night, but I sleep very regularly, consistently four hours a night. No, you need both, but regularity. I was someone who based on my remarkably vanilla and pedestrian personality, I've always been quite regular in my regard. But goodness me, even when I read that paper, I thought I'm doubling down on regularity. It's so important. That tells us, I think something that is in some ways a story not about sleep. It's a story about your circadian rhythm.Matt Walker (27:02):We speak a lot, or I speak a lot about sleep, and I think I've probably done a mis service to the other aspect of the sleep wake rhythmicity, which is called your 24 hours circadian rhythm. Now your sleep pressure, the drive to sleep is independent of your circadian rhythm, but they often work beautifully in harmony with each other, and you fall asleep, and you stay asleep. But I think the circadian system is critical because, excuse me, and what the circadian rhythm also regulates, sneezing right at the inopportune moment when you are recording a podcast. But nevertheless, what that tells me is that when you feed your brain signals of wake sleep consistency, which is to say wake, sleep, timing, regularity, there is something about feeding the brain signals of regularity that anchor your 24-hour circadian rhythm and as a consequence, it improves the quantity and the quality of your sleep. They're intertwined.What About Sleep Trackers?Eric Topol (28:09):That's a terrific explanation for what I think a lot of people don't appreciate it's importance. Now, last topic about tracking. Now we understand how important sleep is. It is the superpower I am with you on that really brought that to light in so many ways. But of course, now we can track it with rings with smart watches and we get these readouts things like efficiency as part of the Oura score and other rings and deep sleep or NREM, REM, the works, you can see your awake times that you didn't know you're awake and the whole bit. Do you recommend for people that aren't getting great sleep quality beyond that they should try to establish a regular schedule that they should track to try to improve it and of course how would they improve it? Or are these things like having a cold mattress temperature that is controlled? What are the tricks that you would suggest for trying to improve your sleep through tracking? Or do you think tracking shouldn't be done?Matt Walker (29:16):Oh gosh, it's such a wonderful question and as with wonderful questions, the answer is usually it's complicated and I have to be careful because for someone who's currently wearing three different sleep trackers, it's going to be hard for me to answer this question completely in the negative. And there are three different sleep trackers. But I would say that for the most part, I like the idea of sleep tracking if you are sleeping well, meaning if as long as you're not suffering from insomnia. The reason is because sleep unlike those two other critical of health, which is diet and exercise, is very difficult to subjectively estimate. So if I were to ask you, Eric, how many times have you worked out in the past week, you'd be able to tell me how cleanly or how poorly have you been eating in the past week. You could tell me.Matt Walker (30:09):But if I was to say to you, Eric, how much deep sleep did you get last Tuesday? And if you don't have a sleep tracker, you'd say, I don't know. And so, there's something useful about tracking, especially a non-conscious process that I think is meaningful to many. And often medicine we say what gets measured gets managed, and there is that trite sort of statement. I do think that that's still true for sleep. So many people I've spoken to have, for example, markedly reduced the amount of alcohol consumption because they've been seeing the huge impact that the alcohol consumption in the evening has on their ring smart ring data as a consequence. So overall, I think they're pretty good. When people ask me what's the best sleep tracker, I usually say it's the one that you wear most frequently because if I come up with a band, headband, chest straps, all sorts of different things and it's a hundred percent accurate, but after three uses of it, you stop using it, that's a useless sleep tracker. So I like to think about sleep trackers that are low friction and no friction. When we go to sleep, we take things off, we don't put things on. That's why I liked things like the ring. For example, I think that's a non-intrusive way. I think the mattress may be as if not better because it's a completely friction less device. You don't have to remember to charge it. You don't have to put it on, you just fall into bed, and it tracks your sleep.Matt Walker (31:40):One form factor, I like to think about sleep trackers is the form factor itself. But then the other is accuracy. And I think right now if you look at the data, probably Oura is winning the ring kind of wars. If you look at all wristband wars, I think it's probably the most accurate relative to something like Fitbit or Apple Watch or the Whoop Band. But they're all pretty close. I think Oura is probably the leader in class right now at least. Keep in mind that I used to be an advisor for Oura. I want to make that very clear. So take what I say with a grain of salt in that regard. I think to your question, well, I'll come back to mattresses in just one second.Matt Walker (32:34):For people who are struggling with sleep, I think you've got to be very, very careful with sleep trackers because they can have the counterproductive effect where I gave you the example of alcohol or eating too late. And these sleep trackers help you modify your behaviors to improve your sleep. Well, there are places where these trackers can actually do you a disservice. When you get so hyper focused on your data and your data not looking good each and every day, it becomes a self-fulfilling prophecy of a negative spiral. And we now have a condition in sleep medicine called orthosomnia. So ortho in medicine typically means straightened. So you've heard of orthodontic straightening teeth, orthopedic straightening bones, orthosomnia is about getting so obsessed with getting your sleep perfect and your sleep straight that it causes an insomnia like syndrome. Now, I don't know, I think the press has made more of this than there is.Matt Walker (33:30):It probably is about 5-7% of the population. I would say at that moment in time, do one of two things. Either take the ring off entirely and just say, I'm going to get my sea legs back underneath me, get some cognitive behavioral therapy for insomnia. And when I'm confident I'll put the ring back on. Or don't throw the baby out with the bath water, keep wearing the ring. Try to say to yourself only on let's say a Sunday afternoon, will I open up the app and look historically what's been happening during the past week so that you keep getting your data, but you don't get the angiogenic daily sort of repetition of reinforcement of I'm not sleeping well. I should also note by the way that I think sleep trackers are not a substitute for either a sleep recording laboratory, but also, they're not a substitute for ultimately telling you entirely how good your sleep is.Matt Walker (34:24):Don't forget, you should always keep in mind how do I feel the next day? Because I think a lot of people will see their readiness score as 92 and they feel miserable. They just feel rough. And then another day, my readiness score was 62 and I just went out and I just ran my fastest five mile that I've done in the past six months. So don't forget that subjective sense of sleep is just as important as objective measures of sleep. The final thing I would say to your point about the mattresses, I actually do think that they are a really great vehicle for sleep augmentation because these smart mattresses, they're filled with sensors, things like Eight Sleep, and they will assess your physiology, they will track your sleep just like a sleep tracking ring. But what's also good is that because they can manipulate temperature and your sleep is so thermoregulatory sensitive that they create this kind, it's almost like this bent arc of thermal story throughout the night because you have to warm up at the surface to cool down at the core to fall asleep, then you have to stay cool to stay asleep, then you have to warm up to wake up and they take you through that natural change.Matt Walker (35:41):But they do it intelligently because they're measuring your sleep minute to minute. And then they're saying, I'm tweaking temperature a little bit. Has sleep improved? Has it become worse? Oh, it's become better. Let's lean into that. Let's get them even colder. Oh, wait a second, it's getting worse. Let's warm it back up a little bit. It's like a staircase method, like a Richter shock. And gradually they find your sweet spot and I think that is a really elegant system. And now they're measuring snoring. Snoring perturbations, and they can augment the bed and raise the angle of the bed up just a little bit so that the gravity doesn't have as much of a hold on your airway because when you're lying on your back, the airway wants to collapse down to gravity, and when you raise back up again, it will change that. And so, I think that there's lots of new advantages in, I think mattress technology that we'll see coming out into the future. I think it's a great vehicle for sleep augmentation.Eric Topol (36:37):That's terrific. Well, this has been for me, very educational, as I would've predicted, if anybody's up on everything in this area, it would be you. So thank you, Matt. It's a really brilliant discussion, really enlightening. We could talk some more hours, but I think we've encapsulated some of the big things. And before we finish up, is there anything else you wanted to say?Matt Walker (37:05):No, I think just to thank you for both your work in general in terms of science communication, your offer here specifically to allow me to try to be a very poorly communicated voice of sleep, and also just what you've done in general for I think the accuracy of science communication out into the public. Please never stop, continue to be a shining light for all of us. You are remarkable. Thank you, Eric.Eric Topol (37:31):Oh, you're very kind. And I look forward to the next chance we get to visit in person. It's been too long, Matt. And all the best to you. Thanks for joining today.************************************************A quick pollI cover much about sleep and healthy aging in SUPER AGERS, which has been on the NYT Bestseller list for 3 weeks. I'm very grateful to many of you for being one of the book's readers.And thanks for reading and subscribing to Ground Truths.If you found this interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years Get full access to Ground Truths at erictopol.substack.com/subscribe

The numbers tell the story. Statistically, it's nearly impossible to scale massively within our industry which is why so few do so. Keith Benjamin is the exception. With over 15 locations under his belt, Keith has broken the mold by systematizing that “it factor” we're all looking to achieve. In today's conversation, we discuss how to build with intention, the tools to create massive awareness, and the essential elements of a cool concept.  For more information on his restaurant group, visit https://uptownhospitality.com/____________________________________________________________Full Comp is brought to you by Yelp for Restaurants: In July 2020, a few hundred employees formed Yelp for Restaurants. Our goal is to build tools that help restaurateurs do more with limited time.We have a lot more content coming your way! Be sure to check out our other content:Yelp for Restaurants PodcastsRestaurant expert videos & webinars

"If you don't impact your environment, your environment's going to impact you." That's how Glenn Wilson, President and CEO of Communities First Inc., sets the tone in this powerful Detroit is Different episode. What started as a casual connection in New Orleans blossoms into a deeply honest conversation about housing, healing, and hope. Glenn shares the raw journey from surviving a childhood house fire in Flint to leading a multi-state nonprofit developing thousands of affordable housing units. From reflections on faith—"Statistically, I shouldn't be here"—to breaking down what “capital stack” really means in community development, this interview is a must-listen. With tales of hot plates on broken stoves, bird nests in rooftops, and turning trauma into mission, Glenn reminds us: “The very things we take for granted are the very things people pray for.” This is about more than real estate—this is about legacy, trust, and doing the work. "It's not about being a gatekeeper. It's about being a gate opener.” Detroit is Different is a podcast hosted by Khary Frazier covering people adding to the culture of an American Classic city. Visit www.detroitisdifferent.com to hear, see and experience more of what makes Detroit different. Follow, like, share, and subscribe to the Podcast on iTunes, Google Play, and Sticher. Comment, suggest and connect with the podcast by emailing info@detroitisdifferent.com

In this episode, we confront a truth many couples avoid: one partner will likely outlive the other. Statistically, especially in heterosexual relationships, it's often the woman. That fact shapes the financial, emotional, and logistical choices couples need to make as they plan for retirement. We talk about why it's essential to create a shared plan—one that not only protects assets, but gives peace of mind to both people involved.We open by acknowledging that in many relationships, one person traditionally handles the finances. If that person passes first, the surviving partner can be left not only grieving, but scrambling to understand the financial puzzle. Amy shares how often she hears from women who feel anxious and uncertain when they're suddenly in charge. These women aren't incapable—they just haven't been part of the process.The heart of our conversation is about empowering both partners to be part of financial planning. Amy outlines the three big areas where questions tend to show up: understanding the financial picture, handling the emotional baggage around trust and confidence, and building knowledge to make informed decisions. It's not about control—it's about shared responsibility and kindness. We highlight how reframing conversations away from aging and death toward security and love can help bring both partners to the table more comfortably.We also touch on how crucial it is for the financially involved partner—often men in older generations—to help build a bridge of understanding and trust. Amy uses the metaphor of setting up a tent: it takes both people holding up their corner to make the structure stand. We talk practical next steps, including setting up regular financial check-ins, building a “what-if” folder with key documents and passwords, and ensuring both partners feel respected and heard in these discussions.Ultimately, we conclude that it's never too late to get involved, and one of the most powerful legacies anyone can leave behind is a partner who feels confident to navigate life after loss. This isn't just about money—it's about care, connection, and preparing for a future that's secure for both people in the relationship. To get in touch with Amy and her team at Thimbleberry Financial, call 503-610-6510 or visit thimbleberryfinancial.com.

Sam received a message from a friend recently. His question was simple: How many people typically give in a church? Statistically, about 75% of people will give in a typical church. In his case, only 50% of the church was giving regularly. Josh and Sam discuss some ways to teach church members about the importance of tithing. The 10% mark can be controversial, but committing to give regularly should not be. The post Five Key Tips to Teach Your Church to Tithe appeared first on Church Answers.

To watch a video version of this podcast, click here: https://youtu.be/Skx7vjdsdo8In this episode, Reuben Saltzman and Tessa Murry discuss the dynamics of home inspection attendance, exploring who should be present during inspections, the roles of buyers and agents, and the impact of these interactions on the inspection process. They share personal experiences and insights on how attendance can affect the quality of inspections and the overall experience for clients. The conversation also touches on the importance of education in the real estate industry and the various types of agents that may be present during inspections. They also discuss the dynamics of home inspections, focusing on the various roles of buyers, agents, and sellers. They explore the unique needs of first-time home buyers, the importance of agent presence during inspections, and the complications that arise when sellers are present. The discussion also highlights the significance of setting boundaries and the impact of unique situations that can occur during inspections. The episode concludes with a call for listeners to share their own experiences.Here's the link to check Inspector Empire Builder: https://events.iebcoaching.com/eventsTakeawaysThe weather in Florida can be quite challenging due to humidity.Health issues can impact professional life significantly.Home inspection attendance has evolved, especially post-COVID.Buyers should ideally attend inspections to understand their future home better.Having agents present can help clarify communication and reduce misunderstandings.Different types of agents can influence the inspection process positively or negatively.Education is crucial for both home inspectors and real estate agents.The presence of children during inspections can lead to distractions and potential issues.Home inspectors appreciate agents who are supportive and engaged during inspections.The inspection process is becoming more complex, requiring more time and attention.  First-time home buyers often feel overwhelmed and need support.Statistically, more single women are buying homes than single men.Agents play a crucial role in providing moral support during inspections.The presence of sellers during inspections can complicate the process.It's generally advised that sellers should not attend their home inspections.Buyers should ideally be present for the last hour of the inspection.Setting boundaries is essential for home inspectors.Unique situations can arise with various attendees during inspections.The role of the seller's agent can vary depending on the situation.Sharing stories from inspections can provide valuable insights. Chapters00:00 Welcome and Weather Check02:58 Health Updates and Professional Endeavors05:54 Home Inspection Attendance: Who Should Be There?12:01 The Role of Buyers and Agents in Inspections17:59 Types of Agents at Home Inspections23:59 The Importance of Education in Home Inspections24:19 Navigating First-Time Home Buyers' Needs29:45 The Role of Agents During Inspections30:10 The Seller's Presence at Inspections37:51 The Impact of Seller's Agents40:32 Unique Situations with Attendees48:32 Final Thoughts on Inspection Attendance

Series: N/AService: Sun AMType: SermonSpeaker: Caleb Smithson

Series: N/AService: Sun AMType: SermonSpeaker: Caleb Smithson

Dr. John Sweetenham shares highlights from Day 2 of the 2025 ASCO Annual Meeting, including new data on the treatment of ER+/HER2-negative breast cancer and potentially practice-changing results for patients with cutaneous squamous cell carcinoma at high risk of recurrence.  Transcript Dr. John Sweetenham: Hello, I'm Dr. John Sweetenham, your host of the ASCO Daily News Podcast, welcoming you to our special coverage of the 2025 ASCO Annual Meeting. Today, I'll be bringing you my takeaways on selected abstracts from Day 2 of the Meeting. My disclosures are available in the transcript of this episode.  Today's selection features important, new data on the treatment of ER-positive, HER2-negative breast cancer, the use of tumor treating fields in combination with chemotherapy for locally advanced pancreatic cancer, and potentially practice-changing results for patients with cutaneous squamous cell carcinoma at high-risk of recurrence.  Our first selected abstract is LBA1000. This important phase 3 study was presented by Dr. Erika Hamilton from the Sarah Cannon Research Institute in Nashville and evaluated the use of a novel agent, vepdegestrant, in patients with ER-positive/HER2-negative breast cancer, which had progressed after first-line endocrine therapy. Vepdegestrant is a selective oral PROTAC estrogen receptor degrader, which targets wild-type and mutant estrogen receptor through a novel mechanism of action which directly harnesses the ubiquitin-proteasome system to degrade ER. It has potential advantages over fulvestrant, a selective ER degrader which has to be administered intramuscularly and has limited benefit in patients who progress after endocrine therapy plus a CDK4/6 inhibitor.  Building on the encouraging results from the initial phase 1/2 study of vepdegestrant, Dr. Hamilton reported results from the VERITAC-2 global phase 3 trial, comparing this agent with fulvestrant. The patients in the study had already received treatment with hormone therapy and a CDK inhibitor and were randomly assigned to receive treatment with either vepdegestrant (313 patients) or fulvestrant (311 patients). The vepdegestrant was taken orally each day, while the fulvestrant was given intramuscularly on days 1 and 15 of the first cycle of treatment and day 1 of each subsequent treatment cycle. Patients were stratified by the presence of wild-type ER or ESR1 mutation. A total of 43.3% of patients had ESR1 mutations; 136 of those were in the vepdegestrant group and 134 in the fulvestrant group.   For patients with ESR1 mutations, vepdegestrant significantly increased progression-free survival compared with fulvestrant. For patients who received vepdegestrant, the median PFS was 5 months versus 2.1 months for those who received fulvestrant. The clinical benefit rate was 42.1% in the vepdegestrant group vs. 20.2% in the fulvestrant group. The overall response rate was 18.6% in the vepdegestrant group compared with only 4% in the fulvestrant group.  The PFS and response benefits of vepdegestrant were largely restricted to the population with ESR1 mutations. Overall survival data are currently immature. The safety profile was favorable, with fewer than 5% of patients having dose reductions or discontinuation due to toxicity. The most frequent toxicities were fatigue, nausea, and elevated transaminases.  The authors concluded that oral vepdegestrant demonstrates statistically significant and clinically meaningful improvement in progression-free survival compared with fulvestrant in this group of patients with ESR1-mutated ER+/HER2- advanced breast cancer who have progressed after endocrine therapy and a CDK inhibitor. Patients with recurrent disease in this context are now routinely tested for ESR1 mutations, and this agent is for sure a potential treatment option for them.  The next study on today's episode, LBA4005, reports on the use of tumor treatment fields for patients with locally advanced pancreatic cancer. Tumor treatment fields are electric fields which disrupt cell division and may also induce an enhanced immune response, using a non-invasive portable device attached to the skin, and are already approved for the treatment of some cancers, including GBM and non-small cell lung cancer. A previous phase 2 trial, PANOVA-2, confirmed the feasibility and safety of using this approach in combination with gemcitabine plus or minus nabpaclitaxel in pancreatic cancer. In today's presentation, Dr. Vincent Picozzi from the Virginia Mason Medical Center in Seattle presented the results of the PANOVA-3 trial, a phase 3 study comparing gemcitabine and nabpaclitaxel with the same chemotherapy plus tumor treatment fields in patients with locally advanced pancreatic adenocarcinoma.  Five hundred and seventy-one eligible patients were enrolled in the study with a total of 405 (198 in the treatment field group and 207 in the standard arm) comprising the modified intent- to-treat population. The duration of chemotherapy treatment was comparable in both study arms, and patients receiving treatment fields had a median exposure of almost 27 weeks.  Statistically significant improvements were observed for several study endpoints, including overall survival (a median of 16.2 versus 14.2 months), distant PFS (at 13.9 versus 11.5 months) and pain-free survival (at 15.2 versus 9.1 months), all in favor of the treatment fields arm. Although quality of life data were not reported in detail, the authors noted a significant improvement in global health status in the treatment fields arm. Safety data showed a higher level of skin adverse events in the treatment fields arm but were otherwise as expected for the GnP combination.  These are quite remarkable results which add to the growing evidence base for tumor treatment fields and are particularly compelling in this patient group given the substantial improvement in pain-free survival. It will be especially interesting to see the mature analysis of the quality-of-life endpoints in a subsequent report.  The final selection today is Abstract 6001, which describes the C-POST trial, a phase 3 trial of adjuvant cemiplimab versus placebo in patients with high-risk cutaneous squamous cell carcinoma of the skin. This study was presented by Dr. Danny Rischin from the Peter MacCallum Cancer Centre in Melbourne, Australia.   Although surgical resection with or without adjuvant radiation is curative in 90% of patients with cutaneous squamous cell carcinoma, high-risk features, including nodal disease, skin and subcutaneous metastases, perineural invasion and bone involvement, predict for an inferior prognosis.  Cemiplimab, a PD-1 targeting antibody is standard therapy for patients with locally advanced or metastatic disease who are not candidates for curative surgical resection or radiation therapy, with an overall response rate of almost 50%.  The C-POST study evaluated the use of cemiplimab as adjuvant therapy following surgery and radiation in high-risk patients, compared with placebo. Treatment was administered at 3-week intervals for 12 weeks, and then 6-week intervals for a further 36 weeks, with a primary endpoint of disease-free survival. Four hundred and fifteen patients were randomized in the study, 209 to cemiplimab and 206 to placebo. With median follow-up at 24 months, Dr. Rischin reported a highly significant improvement in disease-free survival for the cemiplimab arm, 49.4 months for placebo versus not reached for cemiplimab, with improvements also observed in the rates of locoregional recurrence and distant recurrence at 80% and 60% reductions, respectively. No new safety signals were observed.  This study is potentially practice-changing and provides strong evidence that cemiplimab should be considered the new standard of care in this clinical context.  Thanks for listening today and join me again tomorrow to hear more top takeaways from ASCO25. If you value the insights that you hear on the ASCO Daily News Podcast, please remember to rate, review, and subscribe wherever you get your podcasts.  Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speaker:   Dr. John Sweetenham   Follow ASCO on social media:    @ASCO on Twitter   @ASCO on Bluesky   ASCO on Facebook   ASCO on LinkedIn    Disclosures:   Dr. John Sweetenham:   No relationships to disclose  

A peak at Mishram, and some closure on Szeth's family flashbacks -- FN Episode 252

In April, we asked VOM Radio listeners to to Christians living in restricted nations and hostile areas. This week, Ty Scott, VOM's Regional Leader for East and Southern Africa, tells us about the work and effort involved in actually placing Bibles into the hands of Christians living in cities and villages in Sudan, Tanzania, or the Democratic Republic of the Congo. Statistically, Kenya, Uganda, Ethiopia, and Tanzania are majority-Christian nations. Yet each has communities where almost every person is a Muslim. How is the gospel spreading in such places? And how are new followers of Christ treated by their families and the wider Islamic community? Ty will share about family persecution in Comoros, a country we've never discussed on VOM Radio, where Christians comprise only tenths of a percent of the population. Listen as Ty and VOM Radio Host, Todd Nettleton, discuss places where ethnic identity and Islam are completely intertwined. As gospel workers share the hope of Christ in those places, they don't ask people to leave their ethnicity but to fulfill what God would have them be. Hear the amazing testimony of a young man who brought his father, an imam (Islamic prayer leader), to faith in Christ, and how the gospel brought many into Christ's kingdom through his father's witness. Ty will also share specific ways you can pray for Christians in eastern and southern Africa.

In April, we asked VOM Radio listeners to sponsor Bible delivery to Christians living in restricted nations and hostile areas. This week, Ty Scott, VOM's Regional Leader for East and Southern Africa, tells us about the work and effort involved in actually placing Bibles into the hands of Christians living in cities and villages in Sudan, Tanzania, or the Democratic Republic of the Congo. Statistically, Kenya, Uganda, Ethiopia, and Tanzania are majority-Christian nations. Yet each has communities where almost every person is a Muslim. How is the gospel spreading in such places? And how are new followers of Christ treated by their families and the wider Islamic community? Ty will share about family persecution in Comoros, a country we've never discussed on VOM Radio, where Christians comprise only tenths of a percent of the population. Listen as Ty and VOM Radio Host, Todd Nettleton, discuss places where ethnic identity and Islam are completely intertwined. As gospel workers share the hope of Christ in those places, they don't ask people to leave their ethnicity but to fulfill what God would have them be. Hear the amazing testimony of a young man who brought his father, an imam (Islamic prayer leader), to faith in Christ, and how the gospel brought many into Christ's kingdom through his father's witness. Ty will also share specific ways you can pray for Christians in eastern and southern Africa. The VOM App for your smartphone or tablet will help you pray daily for persecuted Christians throughout the year, as well as providing free access to e-books, audiobooks, video content and feature films. Download the VOM App for your iOS or Android device today.

On Monday, President Donald Trump signed an executive order telling drugmakers to slash the prices of their medicines. Once again, the president showed an amazing nose for interesting questions. Statistically, the U.S. accounts for 4 percent of the world's population but nearly 50 percent of global pharmaceutical spending. Americans spend three to five times more on new branded drugs than people in Europe. Why? And what's the matter with fixing this problem by just telling pharmaceutical companies that their prices are too damn high? Today's guest is Jason Abaluck, a health economist at Yale University. We talk about why Americans pay so much for new drugs but, ironically, pay so little for old drugs. We unpack trade-offs between low prices and innovation. And finally, we consider several ways we can have our cake and eat it too: more miracle drugs and more affordability. Because, after all, what is this whole conversation about besides the obvious: How do we design a world in which imperfect people working at imperfect companies nonetheless collaborate to build therapies that save and extend our lives with products we can actually afford? If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Jason Abaluck Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

On this episode of the Exhaust Notes Podcast, Todd, Rohit, and Nick get into a humorous yet insightful discussion about the recent Miami Grand Prix, the upcoming Monaco race, and the evolving dynamics within Formula One. They analyze the performances of drivers like Oscar Piastri and Lando Norris, exploring the implications of their standings in the championship. The conversation also touches on the challenges faced by Nico Hulkenberg and the controversial figure of Flavio Briatore, all while maintaining a light-hearted tone that reflects the hosts' camaraderie. In this episode, the hosts discuss the recent leadership changes at Alpine, including the resignation of team principal Ollie Oakes and the controversial return of Flavio Briatore. They analyze Alpine's current performance in the F1 standings and the implications of the ruthless driver market in Formula One. The conversation shifts to the future of F1 broadcasting, highlighting the potential for streaming services like Apple and Netflix to take over. Finally, they brainstorm innovative ideas for a comprehensive motorsport streaming app.Support The ShowWatch Full Episodes on Patreon

Statistically speaking, Belichick could kick the bucket at any moment. When you consider how bad Brian needs a house, he'd be a fool not to! Chicago’s best morning radio show now has a podcast! Don’t forget to rate, review, and subscribe wherever you listen to podcasts and remember that the conversation always lives on the Q101 Facebook page. Brian & Kenzie are live every morning from 6a-10a on Q101. Subscribe to our channel HERE: https://www.youtube.com/@Q101 Like Q101 on Facebook HERE: https://www.facebook.com/q101chicago Follow Q101 on Twitter HERE: https://twitter.com/Q101Chicago Follow Q101 on Instagram HERE: https://www.instagram.com/q101chicago/?hl=en Follow Q101 on TikTok HERE: https://www.tiktok.com/@q101chicago?lang=enSee omnystudio.com/listener for privacy information.

Statistically, the vast majority of us are fearful about messing up God's plans for our lives. Brian McCormack uses a look at the life of Paul to build a list of principles to inform our understanding of God's plan, and provide a process for making big decisions as a follower of Jesus. For more information about Breakaway, check out www.breakaway.org and follow us on social media @breakawaymin. If Breakaway has impacted your life and you want to generously give back, visit www.breakaway.org/give

Growing up is hard enough, but for the children of serial killers, the weight of their parents' horrific crimes is a shadow that never fades.Darkness Syndicate members get the ad-free version. https://weirddarkness.com/syndicateInfo on the next LIVE SCREAM event. https://weirddarkness.com/LiveScreamInfo on the next WEIRDO WATCH PARTY event. https://weirddarkness.com/TVIN THIS EPISODE: Many people have claimed to see ghosts near the iconic “Hollywood” sign in California – but one particular ghost is seen more often than the others – and it comes with a sad story. *** Weirdo family member Andrew Horne tells of his ghostly experience in Gettysburg. *** Why did Nellie Blye intentionally check herself into an asylum for a harrowing ten days? *** Statistically speaking, you will walk past a murderer 10.76 times in your life. But what if you didn't just walk past a murderer - what if they were a part of your family and you didn't know it?CHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Disclaimer and Show Open00:01:48.735 = The Children of Serial Killers00:31:10.541 = Hollywood Sign's Lady in White00:35:02.092 = Ghosts In Gettysburg00:39:18.622 = Nellie Bly's Living Nightmare00:43:30.805 = Show Close00:44:02.975 = Final ThoughtSOURCES AND RESOURCES FROM THE EPISODE…Episode Page at WeirdDarkness.com: https://weirddarkness.com/ChildrenOfSerialKillers“The Children of Serial Killers” by Stefanie Hammond for Ranker: https://weirddarkness.tiny.us/557775be“The Hollywood Sign's Lady In White” posted at RealParanormalExperiences.com: (link no longer valid)“Ghosts In Gettysburg” by Weirdo family member Andrew Horne – submitted directly to Weird Darkness.“Nellie Bly's Living Nightmare” by Orrin Grey for The Line Up: https://weirddarkness.tiny.us/nellie-bly=====(Over time links seen above may become invalid, disappear, or have different content. I always make sure to give authors credit for the material I use whenever possible. If I somehow overlooked doing so for a story, or if a credit is incorrect, please let me know and I will rectify it in these show notes immediately. Some links included above may benefit me financially through qualifying purchases.)= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2025, Weird Darkness.=====Originally aired: November, 2018TRANSCRIPT: https://weirddarkness.tiny.us/37h8eewc