Podcasts about strategia

Małe grupy: teacherola.com/grupyIndywidualne lekcje: teacherola.com/wspolpracaW tym odcinku poznasz strategię, która naprawdę odmieni Twój angielski mówiony. Opowiem Ci historię, która świetnie pokazuje różnicę między biernym słuchaniem a prawdziwym mówieniem. Zrozumiesz, dlaczego nawet po latach nauki wciąż trudno Ci mówić i co zrobić, aby to w końcu zmienić.Dowiesz się:✔️ dlaczego samo słuchanie podcastów i oglądanie filmów nie wystarczy✔️ czym jest serce języka i dlaczego to nie jest ani gramatyka, ani słownictwo✔️ jak działa mój program Voice Loop i dlaczego codzienna praktyka w grupie jest przełomem✔️ jak wygląda proces uczenia się w Voice Loop: nagrania w WhatsAppie, feedback, rozmowy na żywo✔️ jak zwykłe rozmowy w hostelu w Berlinie mogą zmienić Twoją pewność siebie w angielskim

In questa diretta scopriremo perché serve una formula per decidere se puntare sul reddito o sul patrimonio!Guarda la replica del webinar “L'immobiliare intelligente" per scoprire opportunità e rischi dell'investimento immobiliare.

C'è una sorta di nuova strategia della tensione che agita l'Europa e mette in allerta la Nato. Tutto è iniziato con lo sconfinamento di una flotta di droni russi nei cieli della Polonia, ma le provocazioni non si sono fermate lì e continuano ogni giorno. Oggi cerchiamo di capire cosa sta succedendo e come Mosca stia tentando di destabilizzare i Paesi europei. ... Per iscriverti al canale Whatsapp: https://whatsapp.com/channel/0029Va7X7C4DjiOmdBGtOL3z Per iscriverti al canale Telegram: https://t.me/notizieacolazione Qui per provare MF GPT ... Gli altri podcast: https://milanofinanza.it/podcast Musica https://www.bensound.com Learn more about your ad choices. Visit megaphone.fm/adchoices

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Twoja marka osobista już istnieje. Nawet jeśli nigdy o niej nie myślisz, ona już coś o Tobie mówi. Pytanie brzmi: czy to Ty ją świadomie kształtujesz, czy pozwalasz, by robili to za Ciebie inni?Dla wielu menedżerów i liderów budowanie marki osobistej brzmi jak dodatkowy obowiązek lub, co gorsza, sztuczna autopromocja.Być może zadajesz sobie pytania:„Czy na moim etapie kariery to jest w ogóle potrzebne?”, „Czy muszę zaczynać od sesji zdjęciowej i logo?”,„Jak to robić w zgodzie ze sobą, bez sztucznego podbijania zasięgów?”.Jeśli te wątpliwości brzmią znajomo, ten odcinek jest dla Ciebie.Joanna Cieślak-Ospalska odpowiada na najczęstsze pytania, które zadają sobie liderzy, i obala mity narosłe wokół personal brandingu.W tym odcinku dowiesz się m.in:Dlaczego właśnie na wysokim stanowisku świadome zarządzanie marką jest ważniejsze niż kiedykolwiek.Od czego zacząć pracę nad marką – poznasz proste ćwiczenia, które pomogą Ci zdefiniować swoje wartości, wyróżniki i to, jak chcesz być postrzegany przez zespół i rynek.Przestań pozwalać, by inni definiowali Twoją historię. Czas przejąć nad nią kontrolę.Umów szkolenie 1:1https://www.naffy.io/joanna-cieslakBądźmy w kontakcie!joanna@markaeksperta.onlinehttps://www.linkedin.com/in/joannacieslak/________O czym jest ten podcast?marka osobista, personal brand, personal branding, szkolenia, marka eksperta, LinkedIn, LinkedIn tips, planowanie, produktywność, cele, podsumowanie roku, marketing, marketing online,________O prowadzącej:JOANNA CIEŚLAK-OSPALSKAtrenerka, * strateżka marek osobistych * autorka dwóch podcastów: “Marka Eksperta Online” oraz “Opanuj LinkedIn”.Od ponad dwudziestu lat pokazuje, jak budować markę, wzmacniać wizerunek i stosować komunikację, która spójna jest z wartościami.Prowadzi szkolenia dot. marketingu online, personal brandingu oraz wystąpień publicznych.Współpracuje z firmami, fundacjami, stowarzyszeniami, osobami indywidualnymi i uczelniami.Jest wykładowczynią na studiach podyplomowych związanych z marketingiem: “Nowoczesny Marketing”, “Executive Marketing”. “Grafika i social media” na Uniwersytecie Merito.Wykłada również na studiach MBA w Wyższej Szkole Gospodarki w Bydgoszczy.Jest opiekunką merytoryczną studiów podyplomowych “Wystąpienia publiczne w biznesie” oraz “Podcasting w firmie” na Uniwersytecie Merito.Jest wykładowczynią na studiach podyplomowych na Uniwersytecie SWPSAutorka i prowadząca podcast Marka Eksperta Online, który dotyczy budowania marki osobistej, działań w Internecie oraz dobrej organizacji pracy; a także podcast “Opanuj LinkedIn”, w którym pokazuje, jak skutecznie działać na LinkedIn.Umów szkolenie 1:1https://www.naffy.io/joanna-cieslakBądźmy w kontakcie!joanna@markaeksperta.onlinehttps://www.linkedin.com/in/joannacieslak/________O czym jest ten podcast?marka osobista, personal brand, personal branding, szkolenia, marka eksperta, LinkedIn, LinkedIn tips, planowanie, produktywność, cele, podsumowanie roku, marketing, marketing online,________O prowadzącej:JOANNA CIEŚLAK-OSPALSKAtrenerka, * strateżka marek osobistych * autorka dwóch podcastów: “Marka Eksperta Online” oraz “Opanuj LinkedIn”.Od ponad dwudziestu lat pokazuje, jak budować markę, wzmacniać wizerunek i stosować komunikację, która spójna jest z wartościami.Prowadzi szkolenia dot. marketingu online, personal brandingu oraz wystąpień publicznych.Współpracuje z firmami, fundacjami, stowarzyszeniami, osobami indywidualnymi i uczelniami.Jest wykładowczynią na studiach podyplomowych związanych z marketingiem: “Nowoczesny Marketing”, “Executive Marketing”. “Grafika i social media” na Uniwersytecie Merito.Wykłada również na studiach MBA w Wyższej Szkole Gospodarki w By

W dzisiejszym odcinku dołącza do nas Piotr Klin, aby opowiedzieć o narzędziach pomocnych w planowaniu startów. Zanim jednak przejdziemy do takich aplikacji jak Best Bike Split, My Windsock czy tabele Danielsa, pokażemy Wam, co ciekawego wydarzyło się w ostatnim tygodniu na triathlonowych i kolarskich trasach. Zdradzimy, jaki sprzęt zwrócił naszą uwagę, kto jest na fali, kto przeżywa słabsze chwile, a kto okazał się małym kłamczuszkiem. Mamy nadzieję, że oglądanie i słuchanie sprawi Wam tyle przyjemności, ile nam dało nagrywanie tego odcinka!00:00 Wprowadzenie do podcastu00:35 Analiza wyścigów i wyników Pogaczara03:24 Ostatnie zawody i ich przebieg08:36 Dramat Haydena Wilda i kontrowersje sprzętowe24:55 Smutne statystyki zawodów T10025:50 Krytyka wyścigów i tras26:01 Analiza testów sprzętu w Silverstone GTN27:52 Wątpliwości dotyczące testowania sprzętu29:30 Wyważenie kół i jego znaczenie32:28 Nowe technologie w rowerach triathlonowych36:08 Szczegóły dotyczące sprzętu Laidlowa43:09 Mistrzostwa Świata w Kigali i polskie osiągnięcia44:32 Sekrety sprzętu kolarskiego47:30 Innowacje w kaskach i butach50:20 Decyzje sprzętowe na mistrzostwach53:34 Promocja kolarstwa w egzotycznych krajach59:13 Weryfikacja umiejętności na trasie01:05:48 Aplikacje wspierające przygotowania do startu01:05:53 Wprowadzenie do MyWindsock i jego funkcji01:09:06 Analiza tras i prognozowanie warunków01:13:56 Porównanie MyWindsock z Best Bike Split01:16:31 Ustawienia profilu i analiza danych01:22:12 Praktyczne zastosowanie danych w treningu01:28:52 Analiza danych i modelowanie01:34:43 Strategia na Marbelle01:37:56 Tabela Danielsa i jej zastosowanie01:43:22 Zakończenie i podsumowanie

Viviana Mazza racconta che cosa ha detto il presidente Usa nel suo discorso all'Assemblea generale delle Nazioni Unite. Federico Fubini spiega che cosa si nasconde dietro l'attacco ibrido a Danimarca e Norvegia, che rivela un'intenzione chiara da parte della Russia (che però smentisce). Giusi Fasano ricostruisce come si è arrivati alla sentenza di primo grado nei confronti del figlio del fondatore dei 5 Stelle e di suoi tre amici, per violenza sessuale di gruppo.I link di corriere.it:Il discorso di Trump all'Onu: «L'Ue deve smettere di comprare gas da Mosca. Il cambiamento climatico è una truffa»Droni su Danimarca e Norvegia: perché riguarda la guerra in Ucraina (e il ruolo di Mosca, anche se smentisce)Ciro Grillo e due amici condannati a 8 anni, sei anni e sei mesi al quarto imputato

STRATEGIA DELLA TENSIONE? - FAUSTO CAROTENUTODiventa un supporter di questo podcast: https://www.spreaker.com/podcast/border-nights--654467/support.

Dziś w programie podsumujemy najważniejsze wydarzenia tygodnia; realizacja strategii współpracy z Polakami za granicą, która zakłada m.in. wspieranie powrotów do kraju, promocję języka polskiego, walkę z wykluczeniem rodaków i zmianę podejścia do finansowania projektów - była tematem pierwszej narady konsulów polonijnych, która odbyła się w Warszawie. Spotkanie zorganizowało Ministerstwo Spraw Zagranicznych - o znaczeniu tego wydarzenia mówi Anna Sochańska, dyr. Departamentu Współpracy z Polonią i Polakami za Granicą MSZ; spotkanie z gościem programu - Grażyną Kulczyk, przedsiębiorczyni, mecenaską sztuki, która w maleńkiej szwajcarskiej wiosce Susch od 2019 roku prowadzi swoje muzeum. Tam, gdzie niegdyś zatrzymywali się pielgrzymi, dziś prezentowane są polskie nazwiska należące do światowej czołówki sztuki. Zapraszamy!

Alexis #saelemaekers si sta prendendo (ancora una volta) il #milan : le strategie per il rinnovo di contrattoDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.

SUPPORTAMI SU PATREON! https://www.patreon.com/kristalcrosspatreon OFFERTA DEL GIORNO: Trine 4 ▶ -92% ▶ 2.46€ https://www.instant-gaming.com/it/4527-comprare-trine-4-the-nightmare-prince-pc-gioco-steam/?igr=kristalcrossgaming La maglietta LFDM sul LFDM STORE! - https://kristal-cross-shop.fourthwall.com/en-eur/ AFFILIATI: INSTANT GAMING: https://tinyurl.com/3ywv525u EMP: https://tidd.ly/3MTjbcC PAMPLING: codice KRISTALCROSS THOMANN: https://thmn.to/thocf/4ucalotott SPONSOR - ABBONAMENTO AL CANALE: https://www.youtube.com/channel/UC-isEtNtS2_30c5ANuEEyKQ/join DONAZIONI: https://paypal.me/kristalcross CAPITOLI: 00:00 Benvenuti su Kristal News! 00:33 SONY CAMBIA ANCORA STRATEGIA? 08:23 Detective Cross 10:40 Il COMMENTO del GIORNO 15:30 Detective Cross 16:04 NEWS A RUOTA 23:41 OFFERTA del GIORNO 24:31 La ELITE dei MALNATI su PATREON! 25:11 Grazie della visione! Le #KristalNews sono anche in PODCAST! https://www.spreaker.com/show/kristalnews-il-podcast Disponibile anche su SPOTIFY, APPLE PODCAST, ecc ecc SECONDO CANALE: https://www.youtube.com/channel/UCO13aJlGKgOVYq7-yMe_lPA SEGUIMI IN LIVE SU TWITCH: https://www.twitch.tv/kristalcrossgaming SOCIAL & COMMUNITY: FACEBOOK: https://www.facebook.com/kristalcrossgaming/ INSTAGRAM: https://www.instagram.com/kristalcrossgaming/ GRUPPO TELEGRAM: https://t.me/joinchat/APAtYQ5DPmVA3AHTl8mBcA VUOI SPEDIRMI QUALCOSA? Mandalo a: BAR 2EMME VIA TORINO 243 SAN BENEDETTO DEL TRONTO 63074 (AP) --------------------- IMPORTANTE SCRIVI NELL'INTESTAZIONE "PER KRISTAL CROSS" ---------------------------------------- VUOI SENTIRE I MIEI LAVORI? IL SITO DEL MIO STUDIO http://www.kristalcrossmusicproduction.com/page0/page0.html LE MIE BAND: THE LOTUS: https://www.youtube.com/user/TheLotusChannel LOST RESONANCE FOUND: https://www.youtube.com/user/lostresonancefound Grazie per la visita da Kristal Cross!Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/kristalnews-il-podcast--4936119/support.

Cześć! Dzisiaj goszczę Wojciecha Morawskiego – współzałożyciela i stratega marki Atlantic. To historia niezwykła: od łóżka polowego, przez rozpoznawalną sieć salonów i status Superbrands, po spektakularny upadek i trzyletnią przerwę. A dziś – powrót na rynek i budowanie silnej marki głównie w oparciu o e-commerce. Jak to możliwe, że firma, która miała 140 mln zł przychodu i zniknęła z rynku, wraca i generuje już 30 mln, w większości ze sprzedaży online?W tym odcinku rozmawiamy o tym, jak przetrwać kryzys, odbudować markę i znaleźć wyróżnik na niezwykle konkurencyjnym rynku. W dzisiejszym odcinku dowiesz się między innymi:Jak reanimować markę po bankructwie i odzyskać zaufanie klientów?Co znaczy „wyróżnij się albo zgiń” w praktyce e-commerce?Jak autentyczność i emocje budują prawdziwą markę?Kiedy outsourcing jest złotem, a kiedy pułapką?Jak wybierać partnerów i współpracowników w e-biznesie?Dlaczego w e-commerce trzeba patrzeć tylko do przodu i działać jak czołgZapraszam do posłuchania!O Wojciechu MorawskimZałożyciel i obecnie główny strateg marki Atlantic – jednej z najbardziej rozpoznawalnych polskich marek bielizny. Od ponad 30 lat związany z branżą fashion i e-commerce. Laureat nagrody Entrepreneur of the Year, twórca marki, która zdobyła status Superbrands. Doświadczył spektakularnego sukcesu, ale także bolesnego upadku – dziś konsekwentnie odbudowuje Atlantic, stawiając na model „lekka firma, duża marka” i rozwój poprzez e-commerce.

SAVICKI - firma, która zaczynała jako lokalny jubiler w Lublinie, a dziś działa już na 11 rynkach i prowadzi sieć salonów premium w całej Polsce. Do tego odcinka zaprosiłem Radosława Gołębskiego, żeby opowiedział o kulisach tej świetnej historii.Porozmawialiśmy o tym, jak wyglądała transformacja marki, jakie bariery musieli pokonać, by klienci zaczęli kupować pierścionki i obrączki online, dlaczego obsługa klienta w SAVICKI to nie slogan, lecz realna przewaga konkurencyjna, i czego nauczyła ich nieudana ekspansja na rynek brytyjski.Jeśli interesuje Cię, jak zbudować markę premium w e-Commerce i skalować biznes poza Polską - ten odcinek jest dla Ciebie.

In questo episodioAnalizziamo una canzoneI rischi di ricominciareChe cosa fare per partire beneCome procedere passo passoEcco come posso aiutartiPrendi la giusta strategia. Scarica l'ebook gratuito e partecipa al mese di accoglienza https://pugnimalago.it/strategyearVuoi capire come la vendita assistita dall'IA può aiutarti a prendere le migliori decisioni? Registrati qui per avere tutto quello che ti serve https://pugnimalago.it/ia/   Leggi gli articoli che ti aiutano a decidere da quali clienti andare e come qui https://pugnmalago.it/basta-suonare-il-campanelloVuoi approfodire il tema di cosa voglia dire realmente #venderevalore? Ecco il minicorso gratuito che te lo spiega semplice. https://pugnimalago.it/corsovv/ e inoltreIl romanzo sulla vendita Il valore del venditore lo trovi qui https://www.amazon.it/Valore-del-Venditore-vendita-sconti/dp/B0D7S96PVT/ in formato podcast è qui  https://www.spreaker.com/show/il-valore-del-venditorePer ricevere i miei appunti personali sul tema VendereValore,  vai qui https://pugnimalago.it/appuntiIl videocorso gratuito sul processo di vendita https://www.youtube.com/watch?v=4dOKslfKveI&list=PLsvBLLrj9ZsV-k29B4q2js6fK1xBWe6Yt&index=10&t=56sDove trovi tutti i nostri articoli nel nostro blog https://pugnimalago.it/articoli/Per entrare nel gruppo di discussione sulla vendita La compagnia: https://t.me/joinchat/f3f4aMd5rLhkNWY8Il canale Telegram d Vendere Valore è questo https://t.me/venderevalore

Host Dr. Shannon Westin and guest Dr. Hani Babiker discuss the JCO article "Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study." TRANSCRIPT TTFields in Locally Advanced Pancreatic Adenocarcinoma Dr. Shannon Westin: Hello everyone, and welcome to another episode of JCO After Hours, the podcast where we get in depth with manuscripts that have been published in the Journal of Clinical Oncology. I am your host, gynecologic oncologist Shannon Westin, social media editor at the JCO, and just excited to be here to learn today about pancreatic cancer. None of our participants have conflicts of interest related to this podcast, and it is my honor to introduce Dr. Hani Babiker. He is an associate professor of medicine, consultant in oncology at the Mayo Clinic in Jacksonville, Florida. Welcome, Dr. Babiker. Dr. Hani Babiker: Hi, Dr. Westin. Thank you for the great opportunity to discuss our trial, and thank you for having me here. I really appreciate it, and I am excited. Dr. Shannon Westin: All right, so are we. So we are going to be talking about “Tumor Treating Fields with Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: A Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study.” This was simultaneously published and presented in the JCO and at the annual meeting of ASCO on 5/31/2025. So, let's level set. Can you speak to us just a little bit about pancreatic cancer? What is the survival, and what is the typical treatment for locally advanced disease? This gynecologic oncologist has not kept up in this field. Dr. Hani Babiker: Absolutely, Dr. Westin, and thank you for that question. Pancreatic adenocarcinoma is a lethal cancer. When I first started my career, the 5-year survival, per the Surveillance, Epidemiology, and End Results, was at 4.5%. I always, whenever I was giving talks, say that I really hope that I will see it in the double digit. Now, the 5-year survival for all pancreatic adenocarcinoma is 13.3%. And the 5-year survival, and although it is a double digit, I still hope that I will see it in a higher double digit in the future. It is even worse in patients with metastatic cancer, about 3% 5-year survival for metastatic pancreatic cancer. It is a dismal diagnosis. I really hope in the future we will find a better therapeutic approach to this lethal cancer. Dr. Shannon Westin: Yes, I just lost a very dear friend and colleague to this disease, so I completely agree with you. Well, now that we are settled kind of with the basics here, I would love to talk a little bit about kind of the primary piece of this intervention, the Tumor Treating Fields. So, how does this work? And what diseases has it gotten indications in as yet? Dr. Hani Babiker: Absolutely. So, Tumor Treating Fields is alternating frequency electrical fields that have been studied preclinically and shown that it abrogates cancer cell proliferation. Earlier on, we knew that it inhibits polymerization of tubulin, and hence, it affects cancer cells from proliferating. Later, we are learning that there are multiple mechanisms of action. It affects permeability, allowing for better drug delivery. It also inhibits cancer cell proliferation through affecting autophagy mechanisms that pancreatic cancer cells will use for proliferating and becoming more aggressive. There is also some early data preclinically in colorectal cancer cell lines and lung cancer cell lines and in vivo models showing that it potentially could activate the microenvironment to make it more pro-immunogenic. We recently published papers showing that it could also affect the nanomechanical properties of the tumor microenvironment within pancreatic cancer, hinting towards affecting, potentially, the stroma. So, there are multiple mechanisms to Tumor Treating Electric Fields. It is a new, novel therapeutic approach. Sometimes when I speak with my trainees, I say, "Well, we have surgery, we have radiation and chemotherapy, and this is something new." Tumor Treating Fields initially was studied in refractory GBM and got an indication there. Subsequently, frontline treatment of GBM in a randomized clinical trial, and then malignant pleural mesothelioma and non-small cell lung cancer. We have studied it in pancreatic cancer. Dr. Shannon Westin: I don't think I have ever heard it described so perfectly. That was brilliant. So thank you, and I hope everyone listening knows that you just got a masterclass on this mechanism. You know, they dabbled in it a little bit in ovarian cancer and it didn't quite make the grade, so I was a little definitely disappointed. But very excited about the data we're going to talk about today. So let's get into the PANOVA-3 study. Can you highlight the overall design and also the key eligibility criteria that would be helpful for our listeners? Dr. Hani Babiker: Absolutely. So, it started off with preclinical work in pancreatic cancer showing Tumor Treating Fields with chemo abrogate cancer cell perforation. It led to a trial, the PANOVA-2 trial, that was run in Europe that showed efficacy for OS and PFS in patients with locally advanced pancreatic cancer, which included metastatic and locally advanced pancreatic cancer, more so in locally advanced that led to the PANOVA-3 trial, which was an international, global study. This was in more than 190 centers, 20 countries in Latin America, North America, Europe, and Asia. It was a randomized trial. Patients were randomized 1 to 1 to either chemotherapy with gemcitabine plus nab-paclitaxel per drug label. The other arm was with Tumor Treating Fields at 150 kHz for a recommendation for patients to wear it 18 hours per day. The primary end point of the trial was OS, overall survival. The secondary end point included other efficacy landmarks such as local PFS, pain control, quality of life, and safety. And there was a post hoc that looked at distant PFS. Dr. Shannon Westin: That's a pretty common secondary end point in pancreatic studies of looking at the pain-free interval. I thought that was really brilliant because, you know, I think in gyn cancers, we see resolution of symptoms as being a really big deal, but it's not necessarily something that we always look at. So I thought that was really nice that you included that. Okay, talk to us a little bit about the population. So, the population that actually got treated in PANOVA-3 is pretty generalizable to what people are treating in the clinic. Dr. Hani Babiker: So, in pancreatic cancer, unfortunately, most of our patients present, approximately 80%, with metastatic disease. Local is divided to resectable, borderline, and locally advanced. We studied this trial, a randomized trial, in locally advanced and unresectable, which is really an unmet need. Most of our patients with locally advanced and unresectable are grouped up with other trials in the metastatic setting without a focus on locally advanced and unresectable, save for a few trials. This year, a trial that we were looking for for a long time, the LAPLACE trial, unfortunately, that we were very excited about, this is a molecule that targeted connective tissue growth factor, that showed earlier efficacy in a randomized trial, did not meet up the median OS end point. And hence, PANOVA-3 is the first trial in locally advanced and unresectable that did meet its primary end point. So, it's a very unmet need in locally advanced and unresectable. A lot of the times, our patients in clinic are treated with frontline chemotherapy that was studied in metastatic disease and locally advanced and unresectable, which include either FOLFIRINOX, NALIRIFOX, or gemcitabine/abraxane. I do have in my clinic multiple patients that would stay on the regimen for such a long time, and then we would have to devise a mechanism of maintenance, although this is not studied really in details, either with capecitabine or dropping the oxaliplatin to continue FOLFIRI. And then we also approach chemoradiotherapy. So the trial was in a disease in pancreatic cancer that really is an unmet need. So the inclusion criteria included a patient with locally advanced and unresectable. These were done at multiple centers. Most of them academic centers were discussed at the tumor board, and if it's unresectable, they will be meeting specific metrics of appropriate liver function tests, kidney function tests, and blood counts. We excluded patients that obviously had, given that these are electric fields, patients that have, for example, stimulators or pacemakers, knowing that this could potentially affect some of these devices. But for the most part, it was locally advanced and unresectable patients with a very good performance status and good counts. Dr. Shannon Westin: That's great. I think everyone's excited to hear about the primary outcome of overall survival. What did you find, and how does it compare to some of the recent trials? Dr. Hani Babiker: We're very excited that it did meet its primary end point of median overall survival. It was very exciting knowing that a lot of us were disappointed a little bit of some of the trials that were presented at ASCO GI, such as the LAPLACE trial that I alluded to. Just before the presentation, the PRODIGE 29 trial that is in locally advanced and unresectable that randomized patients with locally advanced disease to either FOLFIRINOX or single-agent gemcitabine, allowing for a crossover, although it did meet its primary end point of PFS, there was no overall survival benefit. So that kind of got us a little bit disappointed, but having the PANOVA-3 trial being positive in median OS got us all excited. In addition, the 12-year overall survival rate was increased in both the intention-to-treat and modified intention-to-treat. The modified intention-to-treat were patients that have had at least one cycle of therapy with TTFields daily and/or one cycle with chemotherapy, which was gemcitabine plus nab-paclitaxel. There was a trend to improvement in PFS and local PFS, although that did not have statistical significance, but the 12-year PFS rate in both the intention-to-treat and modified intention-to-treat was significant. For me, as one of the investigators, that told me that there might be a specific biomarker that would tell me that patients could respond greater than others, more exceptional than others, given that 12-month PFS rate was improved. On a post hoc analysis, the distant PFS was improved with the intervention of Tumor Treating Fields with gemcitabine plus nab-paclitaxel. In addition, there was an improvement in global health status and quality of life in addition to pain-free survival, which is a strong hurdle in our patients with pancreatic adenocarcinoma that most present with significant abdominal pain. Dr. Shannon Westin: One of the other questions that I think has come up is around central review. So did you all use central review in this study? Dr. Hani Babiker: Most of the centers were academic centers. These were discussed in tumor boards, which included radiation oncologists and surgeons. I wanted to point out that it's very important to note that the primary end point was overall survival. So the primary end point was not PFS. Hence, the central review would help us, for example, with elaborating and making sure patients were actually locally advanced disease, but in a setting where the primary end point is overall survival, that was the key point of the clinical trial. This trial was discussed at academic centers, and all included tumor boards to decide if patients were locally advanced or not. In the trial, there was a good proportion of patients, or percentage, that had a CA 19-9 more than 1000. That could indicate that potentially there are a fraction of patients that actually had metastatic disease, micrometastatic disease. So that could hint towards why the median OS was slightly lower then in both arms when compared to, for example, the trial that was presented at ASCO GI, the LAPLACE trial. However, having said that, we were very excited about the trial. It was the first positive trial in locally advanced and unresectable to meet median OS survival. Dr. Shannon Westin: It's so awesome. So congratulations. Okay, so let's talk a little bit about your very detailed secondary end points because you had a lot of really prudent choices there. So anything that was interesting or informative in those end points? Dr. Hani Babiker: One major hurdle back we have for most of our patients with pancreatic adenocarcinoma, like I mentioned earlier, is pain. We try to approach it, obviously, with narcotics. If it doesn't work, we try to do celiac axis block interventionally, and that sometimes is successful and sometimes is not. So actually, to see the pain-free survival end point to be met was very exciting for us. And as for me, as a scientist that studies TTFields in clinic and lab as also to develop a mechanism and understanding really how that works. That was very important for us that in addition to chemotherapy, it improved pain-free survival or deterioration of pain. And most importantly, our patients with pancreatic cancer, this disease is very aggressive. It affects quality of life of patients. Patients feel fatigued, tired. It's a procoagulant tumor that causes clots and strokes, etcetera, marantic endocarditis. And one big problem we deal with when we're seeing patients in clinic is obviously that quality of life. Although data have shown with treatment, with frontline regimens, that quality of life improves with treatment and chemotherapy, it's actually great to see that that improvement happens early in addition to Tumor Treating Fields. The other interesting point was that it was not only pain and quality of life, but also digestive symptoms that are improved with this intervention, knowing that a lot of our patients do have pancreatic cancer, pancreatic exocrine insufficiency that affect also with digestion, and a lot of our patients have abdominal pain after eating and diarrhea. So it was interesting to see that also improved with the intervention. Dr. Shannon Westin: You have touched a little bit on some of the adverse events, kind of with the TT mechanisms, but I'd love to hear a little bit more detail around adverse events in general in this study, as well as specific AEs related to the Tumor Treating Fields. Dr. Hani Babiker: Absolutely. So when we compared both arms, there was a similar toxicity related to the regimen, mostly with chemotherapy, but in specifically to Tumor Treating Fields, there was a rash, and that included dermatitis and rash. Most of the side effects were grade 1 and grade 2. Grade 3 toxicities related to skin was less than 10%, approximately 7% to 8%, and hence did not affect many patients. But it was something to note, and it's something that in the future, when we develop a mechanism of treating patients to note early. We in our clinic have learned to treat patients in the clinical trial early with topical steroids to each patient, of shifting the arrays to mitigate some toxicity and rash. We do advise our patients in hot areas, we keep them aware that sweating, for example, can lead to higher conductivity of electrical fields with a predisposition for rash. So if there's an opportunity to stay in a little bit of a cold area, make sure that the arrays are shifted, use topical steroids early. If it's a significant rash, to hold treatment for at least 48 hours and speak to the investigators. And through these mechanisms, we have learned that we were able to mitigate the rash quite a bit. Dr. Shannon Westin: That's awesome. Thank you so much. Yeah, I'm, it's summer right now, and I think- I'm in Texas, you're in Florida, like we know. Okay, so I guess, again, you have been kind of touching on this, but I would love to know, like if in the quality-of-life assessments or if just in your discussions with patients, like how easy is this to use? How easy is the Tumor Treating Fields device to use, and what do patients really think? Dr. Hani Babiker: Absolutely. We have learned that whenever we speak with patients, it's always good to discuss with them briefly the science of it. A lot of patients would want to know if it's interventional, is that something that goes, is delivered percutaneously or not, and we explain that these are delivered through arrays that are through the skin. We always touch base with them about a lot of question I get about mechanism of action and then about compliance. So I think one important thing to note is that compliance with the use of the device is a lot of the question we'll get quite a bit. Patients know there's going to take an effort from them, and some of my patients enjoyed it because they felt like they also are fighting the disease by wearing the device. I have learned very quickly that having a team, surrounded by a team that knew how to mitigate some of the side effects and knew how to explain how to use the device helped quite a bit. And this included some of our nurses and our nurse practitioners and our clinical research coordinators who've done a wonderful job of showing these arrays actually to patients before they start on the trial, look at it, know how it works. The other point to know is that the sponsor provided Device Support Specialist, we call them DSS, they have been instrumental in helping us, helping the patients know how to use the device, how to use the generator, how to change the batteries, and that helped us conduct the trials and enroll very well. I would envision in the future with education and relying on the Device Support Specialist and having a team that knows how to use the device and mitigate some of the side effects will go a long way for patients to learn about this treatment. Many of the times our patients said while they are on the clinical trial felt like they are also being part of this team in applying the device and fighting the cancer. Dr. Shannon Westin: That's awesome. Well, I guess the bottom line. Is it ready for prime time? Is this something you are going to use for your patients in the clinic? Dr. Hani Babiker: Absolutely. In a disease that has poor prognosis, and we are trying our best to find new treatments to fight this cancer and treatment modalities, presenting patients with all the treatment options that are out there would be recommended. It's what I would do it for in my clinic. And you know, it's funny that I am mentioning that right now. I had a patient who was seen internationally asking about the trial and the device and had locally advanced and unresectable before they start frontline treatment. I do think that there is going to be an educational piece. Obviously, this is not a pill, it's not an intravenous chemotherapy that we're very well and accustomed to. And some of us in academic centers know it very well. I usually joke that whenever I am talking about it in pancreatic cancer, if there is a radiation oncologist in the room, they will be like, "Yeah, we know all about it. We have been treating patients with GBM over there." So a lot of the times, when we first went to trial, if I had any questions, I would call them and ask them. So from their perspective, they, because they use it as a standard of care in treatment of GBM, they develop significant expertise in it. I think in the GI world, specifically and with oncologists that treat pancreatic cancer and specifically oncologists in the community, learning about the device and how to use it, how to recommend it, how to mitigate side effects, will be hopefully for prime time in the future. Dr. Shannon Westin: That's great. Sounds like some real educational opportunities there. Well, this has been awesome. Thank you so much, Dr. Babiker. I mean, I learned a ton, and I wish that we could find a way to use this in gynecologic cancers, but really, really just want to commend you on the design of the trial and the success in this really devastating disease. So again, this was "Tumor Treating Fields with Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: A Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study." And as always, I am your host, Shannon Westin. Please go check out our other offerings wherever you get your podcasts and have an awesome day. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   Dr. Babiker Disclosures Consulting or Advisory Role: Endocyte, Celgene, Idera, Myovant Sciences, Novocure, Ipsen, Caris MPI, Incyte, Guardant Health Speakers' Bureau: Guardant Health Research Funding:  Spirita Oncology, Novocure, AstraZeneca, JSI, Incyte, Qurient, HiFiBiO Therapeutics, Revolution Health Care, Elevation Oncology, Dragonfly Therapeutics, Zelbio, BMS, Mirati Therapeutics, Strategia        

Rosyjskie drony naruszyły polską przestrzeń powietrzną, rząd ogłosił strategię rozwoju kraju do 2035 roku, a Smyk przygotowuje się do wejścia na giełdę. Donald Trump naciska na UE w sprawie ceł wtórnych wobec Chin i Indii.0:00 - Skrót najważniejszych informacji0:55 - Rosyjskie drony nad Polską3:17 - Strategia rozwoju Polski do 2035 roku4:30 - Najważniejsze informacje z polskiej gospodarki5:11 - Najważniejsze informacje ze światowej gospodarki9:28 -Smyk przygotowuje IPO10:42 - Dane z rynków i kalendariumKup subskrypcję „Rzeczpospolitej” pod adresem: czytaj.rp.pl

In questa puntata di Pionieri del Tech, Alex Pagnoni intervista Roberto Fumarola, CEO di Qapla', per esplorare un tema spesso trascurato: la fase di consegna come touchpoint strategico per la customer experience e la fidelizzazione.Perché ci concentriamo solo sull'acquisizione e dimentichiamo che la vera esperienza inizia dopo il checkout?Dalla delivery experience al tracking personalizzato, passando per le API e il ruolo dell'AI nella logistica: scopri come trasformare ogni consegna in un'opportunità di branding, marketing e customer retention.

Ti senti spesso stanco, ti gira la testa quando ti alzi o ti senti svenire senza un motivo preciso? Potrebbe essere colpa della pressione bassa. È una condizione molto comune, ma spesso sottovalutata. In questo video vediamo insieme perché succede e, soprattutto, cosa puoi fare per stare meglio._____________________________________________________________

Polska może być zwornikiem regionu, jeśli zbuduje własny przemysł obronny i wprowadzi strategię ustawową – ocenia w Poranku Radia Wnet Piotr Woyke, dyrektor Instytutu Wschodniej Flanki.Polska armia nie utrzyma zdolności bojowych, jeśli w całości będzie oparta na imporcie broni – ocenia Piotr Woyke, dyrektor Instytutu Wschodniej Flanki. Jego zdaniem konieczne jest wprowadzenie długoterminowej strategii przemysłu obronnego na poziomie ustawy i stworzenie organu koordynującego cały sektor. Żaden premier RP nie dopuści do bankructwa Ministerstwa Obrony Narodowej, zwłaszcza gdy mamy palącą się granicę wschodnią i wojnę tuż obok. Ale problem struktury długu i finansowania zbrojeń jest realny. W krótkiej perspektywie może zacząć przygniatać budżet MON-u– powiedział Woyke, odpowiadając na pytanie czy MON stanie się niedługo niewypłacalny. Jak podkreślił, trzeba uniknąć sytuacji, w której Polska staje przed wyborem „armat albo masła”, kosztem polityki społecznej czy gospodarczej.Własna produkcja zamiast importuKluczowym rozwiązaniem jest rozwój rodzimego przemysłu.Kupując w Polsce, mamy ogromne zwroty podatkowe. To nie tylko bezpieczeństwo, ale też oszczędności w budżecie– wskazuje dyrektor Instytutu.Przypomina, że polska zbrojeniówka była ofiarą nieudanych konsolidacji i politycznych rozgrywek, a spółki państwowe często nie znały potrzeb wojska.Nikt nie może sprawnie zarządzać firmą, jeśli nie wie, czego oczekuje klient. Wojsko zmieniało wymagania, nie informowało spółek, a na koniec kupowało sprzęt zagraniczny– mówi Woyke.Amunicja i dronyEkspert wskazuje, że Polska powinna skupić się na specjalizacjach, które można szybko rozwinąć. Jednym z przykładów jest produkcja amunicji wielkokalibrowej.To absolutnie podstawowa rzecz na współczesnym polu bitwy. Zużywa się jej tysiące sztuk dziennie. A jej produkcja nie jest szczególnie skomplikowana– zaznacza.Jako przykład „diamentu” polskiej zbrojeniówki wskazuje Grupę WB – dziś jednego z największych producentów dronów w Europie.Ta firma działa skutecznie, dostarcza sprzęt na czas i zdobywa kolejne kontrakty eksportowe– mówi.Strategia i koordynacjaWoyke podkreśla, że wszystkie kolejne rządy przez 30 lat nie miały spójnego pomysłu na przemysł obronny.To nie jest ani sektor wolnorynkowy, ani czysto bezpieczeństwa narodowego. To bardzo trudna branża, z niewielką liczbą klientów. Wymaga aktywnej roli państwa– ocenia.Rozwiązaniem ma być strategia ustawowa i jeden koordynator w rządzie.Potrzebny jest organ, który obejmie całość – zarówno przemysł państwowy, jak i prywatny. Musi mieć kompetencje gospodarcze, znać potrzeby armii i wspierać eksport. Żadna firma nie utrzyma się długo z jednego klienta– wskazuje.W jego ocenie konieczny jest też fundusz wsparcia przemysłu obronnego, który dostosowywałby pomoc do skali firm – od gigantów jak PGZ czy WB po małe start-upy.Polska jako zwornik regionuDyrektor Instytutu Wschodniej Flanki wskazuje na przykład Turcji, która dzięki konsekwentnej polityce rozwinęła własny przemysł obronny, dziś produkując samoloty, czołgi czy drony.Turcja pozyskiwała technologie, ale teraz dysponuje własnością intelektualną i swobodą eksportu. Polska powinna mieć podobny cel– podkreśla Woyke.Podsumował, że „wizyta prezydenta Nawrockiego w Waszyngtonie pokazała jasno, że istnieje szansa, aby Polska była traktowana jako zwornik regionu – przynajmniej w zakresie bezpieczeństwa”.

Join Maximal Fire as we dive into the latest release for Legions Imperialis - the Liber Strategia! In this episode, we explore the new updates and strategic shifts in this latest expansion. Discover how detachments have changed, the impact of new iconic formations, and who the biggest winners and losers are in this game-changing update. Whether you're a veteran player or new to Legions Imperialis, this episode is packed with insights and tips. Join our vibrant community and share your thoughts on the latest changes. Subscribe now and stay ahead in the game! Blog and Articles: https://maximalfire.com/articlesWatch our other podcasts here! - https://www.youtube.com/playlist?list=PL82UVANZcT11sTvTQ3yzgKTVeYOcgTpg4 Additional podcast content - "The Noosphere" is available now through our Patreon located here: http://www.patreon.com/maximalfireOr join our new YouTube Members! https://www.youtube.com/channel/UCUrRZKbZ_dW4F3M-7ztFjWQ/joinhttp://maximalfire.comDiscord: https://discord.gg/5ruErzhsHaFacebook: www.facebook.com/maximalfireInstagram: @maximal.fireSponsored by EntoymentGet 10% off your first nameplate order with code "newbuilders" at https://www.BattleBuilder.netTimestamps:00:00:00 Intro00:19:20 The Preorder00:22:25 The Big Losers00:53:35 The Big Winners01:36:56 Final Thoughts#legionsimperialis #epicscale #summerpreview #warhammer #horusheresy #liberstrategia #maximalfireMusic:✘ Title: Killers✘ Music: Kevin MacLeod✘ License: CC BY 3.0 (⁠⁠http://goo.gl/BlcHZR⁠⁠)✘ Title: Suspense-war-teaser-ident-the-beginning-of-life-131572✘ Music: Alex Grohl✘ License: Pixabay ✘ Licensee: MaximalFire7

Diventa un supporter di questo podcast: clicca qui.➨ Iscrivetevi al nostro canale Telegram: clicca quiUniversità degli Studi di Milano, aprile 2011.Registrazione parziale del convegno «Chi è Stato? La strategia della tensione in Europa (1969-1974)», organizzato dal Laboratorio Lapsus.Interventi:Aldo Giannuli, già docente di Storia contemporanea all'Università degli Studi di Milano e consulente di diverse procure (tra cui Milano, per la strage di piazza Fontana, e Brescia, per la strage di piazza della Loggia). Titolo dell'intervento: «Lo scenario internazionale tra consolidamento e rotture».Dimitri Deliolanes, corrispondente della TV greca ERT e autore di numerosi lavori sul contesto storico-politico greco. Titolo dell'intervento: «L'attività eversiva del regime dei colonnelli in Italia e in Grecia».Mirco Dondi, docente di Storia contemporanea all'Università di Bologna. Titolo dell'intervento: «L'Italia e la democrazia anomala».Tra gli argomenti trattati all'interno della registrazione: 1) Sulla corretta definizione di «strategia della tensione»; 2) La politica della distensione; 3) La teoria della «guerra rivoluzionaria»;  4) Grecia, Indonesia, America latina;  5) Il ruolo della Francia; 6) Destabilizzare per stabilizzare; 7) La firma dei trattati di Helsinki; 8) «All'insaputa della CIA». Sul regime del colonnelli, in Grecia; 9) Cipro; 10) Sulla attività eversiva dei colonnelli in Italia; 11) Il «piano Demagnetize»; 12) Le «Stay behind» europee; 13) Uomini del negoziato e trame repressive; 14) Forze armate e Confindustria; 15) Tra illegalità e complicità internazionali.

Come ha fatto un fast food a convincere il presidente Obama ad ordinare in uno dei loro ristoranti? Ascolta il podcast STORIE di BRAND - ⁠⁠⁠⁠⁠https://spotify.openinapp.co/zp15q⁠⁠⁠⁠⁠ Entra nel Canale TELEGRAM - ⁠⁠⁠⁠⁠https://t.me/storiedibrand⁠⁠⁠⁠⁠ Storie su YOUTUBE - ⁠⁠⁠⁠⁠https://www.youtube.com/@StoriediBrand⁠⁠⁠⁠⁠ Seguici su INSTAGRAM -⁠⁠⁠⁠⁠ https://www.instagram.com/storiedibrand/?hl=it⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Transformacja energetyczna, dążenie do neutralności klimatycznej i utrzymanie konkurencyjności na globalnym rynku – oto wyzwania, przed którymi stają dziś największe koncerny. W jaki sposób ORLEN planuje swoją przyszłość w perspektywie najbliższej dekady i dalej?W najnowszym odcinku naszego MamStartup Podcast zagłębiamy się w kulisy funkcjonowania jednego z kluczowych działów ORLEN, aby zrozumieć, jak założone cele przekuwane są w realne projekty.Na temat strategii, innowacji i przyszłości w czasach transformacji energetycznej rozmawiamy z dr. Tomaszem Łęckim, kierownikiem projektu w Dziale Strategicznych Projektów B+R ORLEN.– W swojej pracy poszukuję nie tylko nowinek technologicznych, które mogą być interesujące dla ORLEN, ale także trendów istotnych w kontekście wyścigu technologicznego – komentuje Tomasz Łęcki.

Un viaggio operativo dentro un'innovazione concreta: come Osculati è passata dal “prodotto” al “servizio” digitalizzando processi core e canali di vendita. Parliamo di ERP (da Navision a Dynamics), WMS con magazzini verticali, catalogo in CMS, e-commerce B2B, business continuity in cloud e prossimi passi sull'AI. Lezioni pratiche per chi guida il cambiamento nelle PMI e nelle mid-cap italiane.L'articolo completo è su Tech 360: https://tech360.media/la-trasformazione-digitale-di-osculati-tra-erp-wms-e-commerce-b2b-e-ai-digital-champions/Capitoli00:00 Intro e contesto “pionieri del servizio”02:30 Le origini e il passaggio generazionale “2,5”06:45 1999: dal Novel NetWare al primo dominio Windows, Word/Excel e listini digitali12:10 2001: cambio ERP verso Navision → Dynamics, regole contabili e velocità inserimento ordini18:40 2007: “dream team” IT+logistica e catalogo in CMS con indicizzazione e multilingua25:00 Dal gestionale “fatto in casa” al WMS industriale e magazzini verticali31:20 E-commerce B2B: metà ordini via portale e database prodotti per i rivenditori36:00 Covid: smart working, continuità operativa e rete pronta41:30 Cloud: perché la business continuity non è “il backup”46:20 Roadmap AI: produttività come servizio al cliente50:00 Consigli ai manager: scegliere contesti aperti all'innovazione53:30 ChiusuraHost e Guest- Host: Alex Pagnoni, Founder di Axelerant- Guest: Alberto Osculati, imprenditore e innovation leader in Osculati

Episode 198– Liber Strategia and 'Terrain' GW sent us a preview copy of the new Legions book and as we explain in the episode we thought it was best to include our chat in the main episode. On top of that we have a little look at Terrain and Line of Sight rules in light of the current discussions going on. Guess what, we ramble a little bit as well, especially around the intro and news...     00:00:00 – 00:21:21 – Intro, Hobby, rambling 00:21:21 – 00:45:59 – News 00:45:59 – 01:43:42 – Liber Strategia 01:43:42 – 02:33:17 – Terrain and Line of Sight 02:33:17 – 02:37:09 – Closing the Show Teespring store: https://teespring.com/en-GB/stores/the-imperial-truth If you want to support the show then consider purchasing from Element Games. http://elementgames.co.uk/?d=10057 Don't forget you can use the codes for extra crystals. Greg – GRE259 Howard – HOW583 You can also support the Patreon here: https://www.patreon.com/TheImperialTruth Or via Ko-fi here: https://ko-fi.com/theimperialtruthfullstride   If you enjoyed the show then please leave a positive review on Itunes. You can contact the show via Greg@TheImperialTruth.com You can follow us on Twitter: Show – @Imperial_Truth Greg – @ChildofFang Also our facebook page: https://www.facebook.com/the.imperial.truth.au And our facebook group https://www.facebook.com/groups/436768449815184/  

Jakson muistiinpanot:https://www.vapautasupervoimasi.fi/blog/verkkokurssi-menestystarinatJaksossa mainitut linkit:Asiakkaideni menestystarinoitaIlmoittautuminen live-koulutukseen, josta et halua jäädä paitsi!

Zapraszam na kolejny "Poranek Geopolityczny" z Jamalem Szpalerskim. Zapoznaj się z warunkami oprocentowania wolnych środków w OANDA TMS Brokers: https://go.tms.pl/bezpaszportuUM Inwestuj w fundusze ETF z OANDA TMS Brokers: https://go.tms.pl/bezpaszportuETF

Come si fa a trasformare una realtà consulenziale in una tech company orientata al prodotto? Quali sono le sfide culturali, organizzative e tecniche?In questo episodio della rubrica CTO Show, Alex Pagnoni intervista Davide Damiano, CTO di Begear, che ha vissuto in prima persona questa transizione strategica e ce la racconta nei dettagli: mindset, organizzazione, resistenze, metriche, benefici.Un confronto ricco di spunti per chi guida team tech, startup, aziende di servizi IT o realtà enterprise che stanno ripensando il proprio modello di business.Scopri come cambiare punto di vista può generare più valore, più ownership e più sostenibilità nel lungo periodo.L'articolo completo è su Tech 360: https://tech360.media/come-e-perche-passare-da-un-modello-consulenziale-a-uno-orientato-al-prodotto-cto-show-137/Capitoli:00:00 Introduzione al tema e all'ospite01:45 Perché oggi è importante parlare di prodotto04:10 Limiti del modello consulenziale07:30 I segnali che indicano la necessità di cambiare10:25 Dal progetto al prodotto: il cambio di mentalità13:20 L'importanza della visione di lungo periodo15:45 Mettere davvero l'utente finale al centro18:15 Cambi organizzativi: team cross-funzionali e processi21:00 Le resistenze culturali e come affrontarle24:20 Il ruolo della leadership tecnica nella transizione26:50 Product engineers, non solo sviluppatori29:30 Dal framework Scrum a Kanban per adattarsi meglio31:00 Velocità vs qualità: come bilanciare33:10 Nuove metriche per misurare il successo del prodotto36:00 Consigli pratici per chi vuole fare il salto38:30 Chiusura e riflessioni finaliHost e ospite:Host: Alex Pagnoni, founder di Axelerant, Tech CEO & CTO Advisor.Guest: Davide Damiano, CTO di Begear. Nato a Napoli e da anni a Milano, è un CTO con una solida esperienza nella progettazione di architetture software e nella gestione di team tech in contesti enterprise. Ha guidato progetti complessi in ambito digitale e platform engineering, con un approccio orientato alla qualità, all'innovazione e alla crescita delle persone. Appassionato di tecnologia, sport e sfide, affronta ogni obiettivo con determinazione, senza mai perdere di vista ciò che conta davvero: la famiglia.

Clicca qui per iscriverti alla Masterclass gratuita:  https://autc.pro/TSSita-pod?utm_source=spreaker&utm_medium=podit&utm_content=474&sl=spreaker-podit-474

Il #milan batte 9-0 il Perth Glory e chiude la tournée. Nel mentre sul #calciomercato tiene ancora banco la vicenda JashariDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.

(00:00:00) Quando l'ecosistema diventa strategia (00:00:13) Introduzione ai Servizi Apple (00:02:57) Apple Care è la number One (00:16:42) Apple diventa operatore? (00:22:55) Apple Intelligence Plus? (00:30:01) E ora? Secondo episodio dedicato ai servizi Apple: Jacopo riflette sull'importanza strategica di questa terza gamba per Cupertino, alla luce dei cambiamenti in atto su hardware e software. A partire dal lancio di AppleCare One – la nuova formula assicurativa che abbraccia l'intero ecosistema – analizziamo il senso della continuità, dell'integrazione e dell'evoluzione del concetto di servizio in stile Apple. Non manca uno sguardo verso il futuro: dall'ipotesi di Apple come operatore mobile alla connessione via satellite, fino ai servizi che potrebbero davvero cambiare le regole del gioco.Visita Digiteee e scopri tutte le notizie sulla tecnologiaSegui Digiteee su TikTokDimmi la tua su Twitter, su Threads, su Telegram, su Mastodon, su BlueSky o su Instagram.Mail jacoporeale@yahoo.it Scopri dove ascoltare il podcast e lascia una recensione su Apple Podcast o Spotify.Ascolta An iPad guy su YouTube Podcast.Supporta il podcast

Chi era davvero Mino Pecorelli, il giornalista scomodo ucciso nel 1979? In questo video ricostruiamo il suo rapporto con il generale Vito Miceli, ex direttore del SID, figura chiave nei servizi segreti italiani degli anni Settanta. Un legame opaco, alimentato da documenti riservati, retroscena esplosivi e sospetti sulla strategia della tensione. Miceli fu coinvolto nel tentato golpe Borghese del 1970, mentre Pecorelli ricevette e pubblicò notizie coperte dal segreto di Stato. Chi proteggeva chi? Chi spiava chi? Un'inchiesta tra giornalismo investigativo, intelligence deviata e trame eversive. ISCRIVITI AL CANALE: https://www.youtube.com/@italiamistero?sub_confirmation=1 #italiamistero #MinoPecorelli #VitoMiceli #GolpeBorghese #SID #StrategiaDellaTensione www.italiamistero.it: https://www.italiamistero.it/ #storai #storiavera #perte

The Summer Preview brought new units and books for Legions Imperialis! Here's what we think is in store for us!Additional podcast content - "The Noosphere" is available now through our Patreon located here: http://www.patreon.com/maximalfirePlease consider supporting the cast through our Patreon including access to a Private Discord Channel and 10% off Battle Bling products! - Patreon: http://www.patreon.com/maximalfireOr join our new YouTube Members! https://www.youtube.com/channel/UCUrRZKbZ_dW4F3M-7ztFjWQ/joinhttp://maximalfire.comDiscord: https://discord.gg/5ruErzhsHaFacebook: www.facebook.com/maximalfireInstagram: @maximal.fireSponsored by Entoyment, Battle Bling, Grim Dark terrain and Troublemaker Games!Get 10% off your first nameplate order with code "newbuilders" at BattleBuilder.net!BattleBuilder: https://www.battlebuilder.netBattle Bling Affiliate Link: https://battleblingstore.co.uk/?ref=gadzxp8qGet your Maximal Fire Merch from Redbubble! https://www.redbubble.com/people/Maximalfire/shop?asc=u00:00:00 Intro00:02:07 The Summer Preview00:08:57 Legions Imperialis Preview00:10:56 Liber Strategia00:50:00 Whirlwinds and Scorpius00:55:57 Vindicators01:00:32 Cerberus Tank Destroyers01:03:09 Typhon Siege Tanks01:09:02 Mastadon01:16:11 Tokens01:17:51 Hobby Chat01:23:16 Final ThoughtsMusic:✘ Title: Killers✘ Music: Kevin MacLeod✘ License: CC BY 3.0 (⁠⁠http://goo.gl/BlcHZR⁠⁠)✘ Title: Suspense-war-teaser-ident-the-beginning-of-life-131572✘ Music: Alex Grohl✘ License: Pixabay ✘ Licensee: MaximalFire7

Potrzebujesz wsparcia w stworzeniu strategii marketingowej? Sprawdź na https://marketingopanowany.pl/ jak możemy pomóc.—Wszyscy słyszeliśmy, że marketing powinien mieć strategię. Ale co to właściwie znaczy? To strasznie popularne słowo, które jednocześnie jest często źle rozumiane. W tym odcinku zebrałem 6 rzeczy, które warto wiedzieć zanim podejdziesz do tworzenia strategii marketingowej w Twojej firmie.Dowiesz się:✅ Jakie błędy popełniamy, gdy zabieramy się do tworzenia strategii marketingowej?✅ Jakie jedno słowo najlepiej podsumowuje strategię marketingową?✅ Jak wykorzystać AI do wdrożenia strategii marketingowej?✅ W jakiej formie zapisywać strategię, żeby była użyteczna?✅ Co jest potrzebne do stworzenia strategii marketingowej?✅ Czym jest, a czym nie jest strategia marketingowa?✅ Jak przejść od strategii do konkretnych działań?✅ Kto powinien tworzyć strategię marketingową?Ten odcinek jest dla Ciebie, jeśli jeśli myślisz o stworzeniu strategii marketingowej i chcesz przejść przez ten proces bez problemów i błędów.Nazywam się Jacek Kłosiński, a więcej o mnie i mojej firmie znajdziesz na https://marketingopanowany.pl/SPIS TREŚCI: 00:00 Wprowadzenie 01:40 Czym nie jest strategia marketingowa 03:05 Jedno słowo, które najlepiej opisuje strategię marketingową 06:03 Od czego zacząć prace nad strategią marketingową 08:00 Co pomaga tworzyć strategię marketingową 11:24 Kto powinien przygotować strategię marketingową 14:25 Jak praktycznie opisywać strategię marketingową 18:26 Podsumowanie

Sylwia Czubkowska jest dziennikarką, reporterką, od wielu lat zajmuje się tematami technologicznymi. Rozmawiamy o jej książkach, pasji do opisywania świata i ciekawości ludzi. Jej dwie niezwykłe książki „Chińczycy trzymają nas mocno” i „Bóg Techy” to szalenie ciekawe spojrzenia na świat przez pryzmat niezwykłych historii i ludzkich przeżyć. Pierwsza książka was przerazi tak, że pojawi się gęsia skórka, druga wejdzie do waszego domu w nocy, zrobi raban i wyrzuci wszystkie rzeczy z waszej szafy. Będzie trzeba wszystko poukładać, ale to nie jest złe. W pierwszej części rozmowy mamy opowieść o drodze świetnej dziennikarki, a w drugiej części rozmowy czeka was niespodzianka. Musicie posłuchać tej rozmowy, bo to są mega ważne tematy. Zmiany dzieją się ogromne. Podczas rozmowy z Sylwią Czubkowską poznałam nowe słowo infodenia – epidemia informacji. Ty też coś dla siebie znajdziesz. Rozdziały w rozmowie: 00:00 – Wstęp 01:54 – Dziennikarska droga Sylwii 11:34 – Bohaterowie książki „Chińczycy trzymają nas mocno” 15:37 – Strategia spowolnienia państwa – jak poruszają się big techy? 18:09 – Jak można zmienić swoje przyzwyczajenia? 25:05 – Musimy mieć podatek cyfrowy. 27:07 – Bonusowa rozmowa z Sylwią o książce „Bóg Techy” Dodatkowe materiały: Moja recenzja książki Sylwii Czubkowskiej: https://tiny.pl/0-h05f12 Moja rozmowa z Sylwią dla Magazynu Pod Prąd: https://youtu.be/eN2XWIdZVTk

Franța a desemnat Rusia drept amenințarea „cea mai directă” la adresa intereselor țării și a stabilității continentului. Iată ce transmite ziarul ucrainean Kyiv Independent, preluat de G4Media. Afirmația apare în noua revizuire strategică națională, a Franței, publicată chiar de Ziua Națională, pe 14 iulie. Strategia de securitate a Franței o spune clar: în anii următori și până în 2030, principala amenințare la adresa Franței și a europenilor este riscul unui război deschis în chiar inima Europei. Documentul constată întensificarea acțiunilor ostile împotriva Franței și a partenerilor săi europeni dincolo de conflictul direct: intimidare nucleară, interferențe în domeniul informației, atacuri cibernetice, sabotaj, spionaj, detenție arbitrară a cetățenilor, survolarea teritoriului anumitor aliați, tentative de interferență în procesele electorale, demonstrații ostile împotriva forțelor franceze și aliate, acțiuni pe teritoriul național. În plus, potrivit analizei Parisului, Rusia folosește toate mijloacele pentru a submina sprijinul pentru Ucraina. Franța a mai avertizat că Rusia încearcă să descurajeze aliații Ucrainei să își sporească sprijinul militar, consolidându-și în același timp propriile parteneriate cu China, Iranul și Coreea de Nord. În paranteză fie spus, priviți doar la narațiunile Kremlinului preluate și distribuite în mediile românești care se autointitulează suveraniste: cum că România alocă inutil resurse pentru sprijinirea Ucrainei, în timp ce guvernul aplică măsuri de austeritate.  Sau că România s-ar pregăti să-și mobilizeze populația pentru a porni la război de partea Ucrainei, împotriva Rusiei. Revenind la documentul de securitate francez, să mai observăm afirmația potrivit căreia Washingtonul urmărește o „politică externă mai puțin previzibilă”, cu consecințe majore pentru NATO și războiul Rusia-Ucraina. În cele din urmă, și într-un sens mai larg, modelul european de democrație liberală și umanism este cel atacat astăzi și contestat într-o ofensivă ideologică globală. Chiar și în cadrul Uniunii Europene (UE), această ofensivă subminează capacitatea noastră de acțiune colectivă, constată documentul.   Dincolo de acestea, acțiunile destabilizatoare ale Iranului au creat condițiile pentru un război generalizat în Orientul Apropiat și Mijlociu. China și-a întărit, de asemenea, poziția cu scopul de a deveni principala putere mondială până în 2050, ceea ce duce la transformări majore în mediul geopolitic și tehnologic global. Astfel că intrăm într-o nouă eră, una cu un risc deosebit de ridicat al unui război major, de mare intensitate. În acest context – spune documentul – este vital să ne pregătim pentru acest scenariu: Franța și europenii trebuie să fie capabili să se apere mai bine și să descurajeze orice nouă agresiune rusească pe continent. Uniunea Europeană și statele sale membre și-au consolidat semnificativ eforturile de apărare și au accelerat crearea de noi instrumente pentru a face față unor amenințări reînnoite. Iar Franța va continua să susțină aceste eforturi, se mai spune în analiza, comandată de președintele francez Emmanuel Macron. Ascultați rubrica ”Eurocronica”, cu Ovidiu Nahoi, în fiecare zi, de luni până vineri, de la 8.45 și în reluare duminica, de la 15.00, numai la RFI România

Intervista a Bruno Rovelli, chief investment strategist per l'Italia di Blackrock Learn more about your ad choices. Visit megaphone.fm/adchoices

(00:00:00) Una rivoluzione dal basso? (00:00:15) L'innovazione sta arrivando (00:02:54) L'evoluzione dell'ecosistema (00:04:26) Un nuovo equilibrio tra hardware e software (00:07:27) Il ruolo dell'intelligenza artificiale (00:10:28) Apple Silicon: un mondo in espansione (00:14:28) La sfida nella fascia bassa (00:17:48) Il nuovo iPad e le aspettative (00:18:15) MacBook Economico: un'Innovazione attesa (00:24:01) Contaminazione tra i dispositivi (00:27:53) Verso il futuro (00:29:37) Riflessioni finali In questa puntata parto da uno dei rumor più discussi dell'estate: il possibile arrivo di un MacBook con processore A18 Pro, che potrebbe rivoluzionare la fascia bassa dei portatili Apple. Analizzo come questa mossa – a cinque anni dalla transizione dei chip M1 su iPad – potrebbe segnare una nuova svolta, contaminando le linee tra Mac, iPad e iPhone. Un episodio ricco di riflessioni su come Apple stia cambiando strategia per conquistare nuovi segmenti di mercato e rendere l'innovazione accessibile a più utenti.La puntata del SaggioPodcast in cui sono stato ospitesVisita Digiteee e scopri tutte le notizie sulla tecnologiaSegui Digiteee su TikTokDimmi la tua su Twitter, su Threads, su Telegram, su Mastodon, su BlueSky o su Instagram.Mail jacoporeale@yahoo.it Scopri dove ascoltare il podcast e lascia una recensione su Apple Podcast o Spotify.Ascolta An iPad guy su YouTube Podcast.Supporta il podcast

Oggi è stato presentato in Senato il Rapporto sulla politica di bilancio a cura dell'Ufficio parlamentare di bilancio (Upb). Dal rapporto, tra i molti temi affrontati, emerge che la stabilizzazione del taglio del cuneo e l accorpamento delle aliquote Irpef della manovra se, da un lato, danno maggiore stabilità al sistema, dall'altro, aumentano la sensibilità dell'imposta personale sul reddito all'inflazione soprattutto per i lavoratori dipendenti. Lo osserva l'Upb che sottolinea che la nuova struttura Irpef, essendo più progressiva, produce un maggior drenaggio fiscale (fiscal drag). In un contesto in cui la dinamica retributiva è già risultata insufficiente a compensare l inflazione, l'intensificazione del prelievo fiscale derivante dall'interazione tra quest'ultima e la progressività dell'imposta rischia di erodere in misura considerevole gli incrementi nominali delle retribuzioni, con potenziali ricadute negative sui consumi e sulla domanda interna. Approfondiamo il tema con Gianni Trovati de Il Sole 24 Ore.Giovani Confindustria: Per far crescere le nuove imprese priorità a Venture capital e IACi sono energie che possono davvero spingere avanti il Paese. Dobbiamo saperle riconoscere e valorizzare, perché l impresa è il vero motore dello sviluppo. Tra i giovani c'è voglia di fare impresa, la loro propensione al rischio va rafforzata e indirizzata. E oggi abbiamo strumenti potenti, come le tecnologie digitali e l intelligenza artificiale, che possono fare la differenza. Per Maria Anghileri, presidente dei Giovani Imprenditori di Confindustria, nel nostro paese la Passione d impresa è forte, e proprio per questo ha scelto questo messaggio come titolo del 54 convegno di Rapallo che si terrà venerdì 13 e sabato 14 giugno. A Rapallo porteremo esempi di imprenditori under 40, di prima, seconda e terza generazione, anche espressione di nuove aziende o di unicorni. Casi di eccellenza, di chi è riuscito ad avere successo in settori innovativi, ma anche in quelli più tradizionali. Ne parliamo proprio con Maria Anghileri, presidente dei Giovani Imprenditori di Confindustria.Dazi, Trump conferma accordo quadro con la Cina: Arriveranno magneti e minerali rariA Londra le delegazioni ai massimi livelli di Stati Uniti e Cina hanno annunciato di aver raggiunto un intesa quadro sul ripristino della tregua che aveva visto i due Paesi sospendere la maggior parte delle rispettive tariffe. Nel frattempo in patria ha strappato alla Corte d Appello una proroga di due mesi, fino al 31 luglio, della sospensione del blocco dei dazi cosiddetti reciproci contro decine di Paesi e che erano stati bocciati come illegali in primo grado da uno speciale tribunale federale sul commercio. L'accordo è stato confermato da un intervento dello stesso presidente Usa sul social Truth, dove scrive: Il nostro accordo con la Cina è stato concluso, soggetto all approvazione definitiva del presidente Xi e di me. La Cina fornirà tutti i magneti e i minerali rari necessari. Allo stesso modo, forniremo alla Cina ciò che è stato concordato, compresi i visti agli studenti cinesi che utilizzano i nostri college e università (cosa che mi è sempre piaciuta!). Nell intesa raggiunta a Londra i dazi resteranno allo stesso livello di quanto stabilito nelle settimane scorse a Ginevra, quando gli Usa si sono impegnati a ridurre le tariffe sul made in China al 30% e la Cina al 10%. Approfondiamo il tema con Giuliano Noci, Professore ordinario in Ingegneria Economico-Gestionale, insegna Strategia & Marketing presso il Politecnico di Milano.Confcommercio, quest'anno al settore mancano 260mila lavoratoriNel 2025 i settori del commercio, della ristorazione e dell'alloggio non riusciranno a trovare circa 260mila lavoratori. È quanto stima l'Ufficio studi di Confcommercio, come presentato in occasione dell'assemblea dell'associazione, rilevando che il dato è in crescita rispetto al 2024 (+4%) e rappresenta una emergenza perché rischia di frenare la crescita economica dei settori considerati e del prodotto lordo dell intero sistema economico italiano. Tra le figure professionali più difficili da reperire in questi settori: commessi professionali, macellai, gastronomi, camerieri di sala, barman, cuochi/pizzaioli, gelatai, camerieri, addetti alla pulizia e al riassetto delle camere. Ne parliamo con Mariano Bella, direttore Ufficio studi Confcommercio.

In this episode of Trust Your Voice, host Sylvie Légère engages in a conversation with crisis communication expert Lissa Druss. As the CEO of Strategia Consulting and a highly decorated television journalist, Lissa shares her expertise in steering through crises, a valuable skill for leaders in politics, business, and community organizations. They explore the art of crisis management and provide essential insights into identifying, addressing, and mitigating challenges that could impact one's reputation.Lissa Druss offers an in-depth exploration of the dynamics of crisis management, beginning with the fundamental question of what constitutes a crisis and how to recognize one. She emphasizes the importance of distinguishing between rumors and genuine issues by relying on gut feelings and informed decision-making. Furthermore, Lissa provides a roadmap for preparing for a crisis, stressing the need to maintain a positive public image through consistent communication and building a network of support. Her advice extends to strategies for responding effectively to media inquiries and managing the narrative to prevent others from defining one's story.Tune in to the full episode to learn more about practical wisdom on handling crises with confidence and poise.  Links and Resources:Strategia Consulting - Lissa Druss's firm specializing in crisis communication. The Policy Circle - Organization co-founded by Sylvie Légère focused on engaging women in public policy dialogues.  About Lissa Druss:For more than 35 years, Lissa has established a powerful reputation– across the country – as a highly seasoned public affairs strategist, crisis management leader, nine-time Emmy award-winning television journalist, media consultant, guest lecturer, and tireless client advisor. In addition to leading the Strategia team, she counsels clients on issues at the intersection of government affairs and lobbying, crisis communications, municipal relations, media relations/training, corporate communications, internal/external communications strategy, and social media. Lissa is also the national government relations director for Riot Hospitality Group, a national hospitality management company based in Scottsdale, AZ.