Greek military leader
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Si moltiplicano gli annunci, gli investimenti e cresce l'interesse per le tecnologie quantistiche. E anche l'Italia ha da poco una strategia per accelerare lo sviluppo di un ecosistema. Enrico Pagliarini ne parla con Tommaso Calarco, ordinario di Fisica all'Università di Bologna, direttore dell'Istituto Peter Grünberg per il controllo quantistico e coordinatore della Strategia italiana sulle tecnologie quantistiche.Dopo tanti anni di investimenti arriva anche in Italia la prima rete 5G "stand alone", una delle poche in Europa, segnando una nuova evoluzione della tecnologia lanciata nel nostro Paese nel 2018. A lanciarla è stata WindTre in collaborazione con Ericsson. Ne parliamo con Carlo Melis, Chief Technology Officer di WindTre.Digital twins programmabili, che permettono agli sviluppatori di simulare e controllare i sistemi automatizzati. È l'ambito operativo di Cyberwave, startup che ha recentemente raccolto 7 milioni di euro in un round di investimenti, come spiega il Ceo e co fondatore, Simone Di Somma. L'Università di Palermo ha adottato un sistema di videosorveglianza che integra video e intelligenza artificiale tra i più grandi in Europa. Pietro Paolo Corso, delegato del Rettore per i Progetti straordinari e le Infrastrutture digitali di Ateneo, ci illustra le caratteristiche principali.E come sempre in Digital News le notizie di innovazione e tecnologia più importanti della settimana.
Care este miza lui Grindeanu prin atacurile la adresa lui Bolojan și de ce nu îl apără liberalii pe premier – INTERVIU (HotNews) - Grindeanu are un plan - să-l distrugă pe Bolojan (SpotMedia) - Ministra de Externe, Oana Țoiu: O să vedem o prezență întărită a NATO în România până la sfârșitul acestui an și anul viitor (Europa Liberă) Exces de zel. Un jandarm l-a amendat pe organizatorul marșului de comemorare a victimelor Colectiv. „Durerea are oră de închidere?” (Adevărul) Marian Rădună, reprezentant al Asociației MEA și unul dintre organizatorii marșului dedicat victimelor incendiului din clubul Colectiv, a fost amendat joi seară de Jandarmeria Română cu 3.000 de lei pentru „depășirea orei de comemorare”. „Legea 60, articolul 3, spune foarte clar că nici măcar nu se notifică comemorările, noi putem să stăm foarte bine toată noaptea pe acolo. Domnul agent constatator nu a ascultat nicio explicație”, a spus Rădună. El consideră sancțiunea nelegală și a anunțat că o va contesta în instanță: „Vom contesta amenda. E frustrant, pentru că este o pierdere de timp. Din păcate, necunoașterea legii e încă la ordinea zilei.” Adevărul mai notează că jurnalistul Marco Badea a criticat decizia Jandarmeriei într-o postare pe Facebook, subliniind că amenda reflectă „o lipsă profundă de empatie și discernământ instituțional” . „Cineva a decis că memoria are program fix și că durerea are oră de închidere. Este un moment care adună în același loc tot ce merge strâmb în felul în care statul își tratează cetățenii: cu suspiciune, aroganță și cruzime birocratică deghizată în regulament”, a mai transmis jurnalistul. Marșul de joi a marcat un deceniu de la tragedia care a schimbat România, iar organizatorii au atras atenția că, după zece ani, „nimeni nu a plătit” pentru cele 65 de victime, iar corupția și infecțiile nosocomiale continuă să facă victime. Care este miza lui Grindeanu prin atacurile la adresa lui Bolojan și de ce nu îl apără liberalii pe premier – INTERVIU (HotNews) Strategia PSD este de a face opoziție din interiorul Guvernului, iar miza lui Sorin Grindeanu este șubrezirea reputației lui Ilie Bolojan, spune analistul politic Adi Zăbavă, într-un dialog cu HotNews. Concluzia expertului vine după ce PSD l-a chemat joi pe premierul Ilie Bolojan în Parlament, pentru explicații cu privire la reacția Executivului după ce SUA a decis să retragă aproape jumătate dintre soldații americani din România. Despre tăcerea venită dinspre liderii PNL, care nu au nicio reacție în favoarea președintelui de partid Ilie Bolojan, Adi Zăbavă spune că pe de o parte, Bolojan face compromisuri pentru a menține stabilitatea în coaliție, iar pe altă parte, amintește că în PNL există și tabăra, destul de numeroasă, care așteaptă să preia conducerea partidului și deci, căderea lui Bolojan. În toată ecuația coaliției, președintele și-a asumat rolul de mediator – a chemat liderii la discuții la Palatul Cotroceni atunci când nu reușeau să iasă din blocaje – fie că era vorba despre reforma administrației publice sau despre reforma pensiilor speciale. Analistul spune că pentru Nicușor Dan primează stabilitatea guvernării, dar că intențiile lui politice nu sunt încă clare. Grindeanu are un plan - să-l distrugă pe Bolojan (SpotMedia) Strategia social-democraților nu este să plece de la guvernare și să facă o nouă majoritate cu AUR. Ar fi o operațiune politică riscantă din cauza luptelor interne din formațiunea extremistă și a reacției de respingere a opiniei publice. Strategia e crearea unui nou USL, care să-l lase în ofsaid pe actualul prim-ministru, iar de sub drapelul pro-europenismului să fie oprite reformele, corupția să meargă înainte, iar privilegiile conservate, consideră jurnalistul Emilian Isăilă. Integral, pe pagina SpotMedia. Ministra de Externe, Oana Țoiu: O să vedem o prezență întărită a NATO în România până la sfârșitul acestui an și anul viitor (Europa Liberă) Ministra de Externe a României, Oana Țoiu, anunță la Interviurile one2one că aliați din NATO, alții decât Statele Unite, vor trimite în lunile următoare noi trupe și echipamente în România. Parteneriatul strategic dintre Statele Unite și România nu va fi afectat de decizia de retragere parțială a unor trupe americane și reconfirmă vizita președintelui Nicușor Dan la Casa Albă, anul viitor. Șefa diplomației române susține la one2one că relația dintre cele două țări este una de încredere care încă se dezvoltă. Oana Țoiu explică că România își dorește ca firme americane din domeniul apărării să investească pe teritoriul național prin programul SAFE al Uniunii Europene. România poate accesa peste 16 miliarde de euro prin acest program, care permite și participarea unor entități terțe.
Fenomen, petarda, inwazja. Wszystkie te określenia idealnie pasują do zjawiska chińskiej motoryzacji. A już zwłaszcza do sektora samochodów elektrycznych, które coraz szerszą falą płyną do Europy. Chiński BYD już przegonił Teslę pod względem wolumenu sprzedaży, a końca inwazji nie widać. Chińskie elektryki są bardzo tanie, bardzo dobrze wyposażone i już zmieniają przyzwyczajenia polskich konsumentów. Jest tylko jeden szkopuł: coraz więcej głosów wskazuje na to, że chińskie elektryki nie tylko zawiozą nas z miejsca A do B, ale też będą słuchać wszystkiego, co w nich mówimy. A w dodatku wyślą to później do Pekinu. Czy faktycznie jest się czego obawiać? A może wpadamy już w antychińską paranoję? W jaki sposób Pekin od zera zbudował tak agresywny sektor, jakim jest dziś chińska motoryzacja? I czy amerykańskie i europejskie cła są w stanie go okiełznać? Między innymi na te pytania odpowiemy w tym odcinku podcastu "Techstorie". GOŚCIE ODCINKA: - Karolina Chojnacka-Chebda, dziennikarka motoryzacyjna w Wyborcza.biz; - Jakub Jakóbowski, wicedyrektor Ośrodka Studiów Wschodnich i kierownik Zespołu Chińskiego; - Piotr Pawlak, prezes nowo utworzonego klastra Toyota Northern Europe, obejmującego 7 rynków w Europie północno-centralnej. ROZDZIAŁY: 03:14 Strategia inwazji 18:03 Motoryzacyjny boom w Chinach 29:20 Buduj swoje marzenia 40:57 Smartfon na kółkach 50:33 Podgląda czy nie? 58:27 Subsydia i wsparcie rządu 01:09:30 Co dalej z produkcją z Europy, Azji i USA? 01:17:46 Kupować czy nie kupować? ŹRÓDŁA: - Celebryci promują Omoda&Jaecoo: https://www.wirtualnemedia.pl/marina-i-wojciech-szczesny-promuja-marki-omoda-jaecoo,7176116753237633a - Buffet inwestuje w BYD: https://www.nasdaq.com/articles/warren-buffett-bought-electric-vehicle-ev-stock-2008-even-after-2000-return-its-still-buy - Historia BYD: https://xyz.pl/king-wang-czyli-chinski-elon-musk/ - Czy Amerykanie powinni kupować chińskie elektryki?: https://www.foxbusiness.com/media/americans-should-absolutely-concerned-about-data-collection-spying-chinese-evs-auto-expert - Ryzyka chińskich elektryków: https://ecfr.eu/article/security-recall-the-risk-of-chinese-electric-vehicles-in-europe/ - Chińskie EV powinny być zakazane w instytucjach publicznych UK: https://cim-coalition.co.uk/collision-course-under-pricing-chinese-ev-risks-in-the-uk/ - Zalecenia dla obronności: https://www.techradar.com/pro/security/uk-defense-firm-warns-staff-against-charging-phones-in-chinese-cars - O ekspansji elektryków z Chin: https://theconversation.com/chinas-electric-vehicle-influence-expands-nearly-everywhere-except-the-us-and-canada-262459 - O zmianach w dopłatach do elektryków w Polsce: https://wyborcza.biz/biznes/7,156481,32237260,wzrosna-doplaty-do-aut-na-prad-ale-tylko-z-europy.html
W tym odcinku rozkładamy cross-border na czynniki pierwsze – bez teorii, bez ściemy i bez marketingowych haseł.Mój gość, Piotr Kiljański – ekspert od ekspansji międzynarodowej i były dyrektor e-Commerce Strefy Tenisa – opowiada, jak w ciągu kilku lat zbudował sprzedaż na 15 rynkach europejskich, co poszło nie tak po drodze (m.in. słynny „rumuński fuckup”
Większość firm ma strategię na slajdach, procesy w Excelu, projekty w chaosie i kulturę tylko na ścianie. W tym odcinku pokażę Ci, jak to wszystko się łączy tak, żeby firma zaczęła działać jak system, a nie jak zbiór przypadków.Bezpłatna konsultacja: https://www.sellwise.pl/1bnaSzkolenia Online (Kod "Proces20"): https://www.sellwise.pl/szkolenia-otwarte/Ogłoszenia o pracę: https://hirewise.pl/praca/
Prof. Andrew Michta tłumaczy, dlaczego decyzje Trumpa są tak nieprzewidywalne, jak wygląda proces decyzyjny w Waszyngtonie i dlaczego amerykańscy politycy wciąż nie rozumieją Rosji.(00:00) Wstęp(1:59) Jak odczytać politykę Donalda Trumpa?(8:15) Jaką rolę odgrywa Marco Rubio?(12:48) Amerykańscy politycy nie znają Rosji(28:25) Co realnie Europa może zrobić?(34:03) Podejście Amerykanów do wsparcia Ukrainy(45:19) Czy USA przeniosą swoje stałe bazy bliżej Rosji?(55:11) Czy widać scenariusz kończący wojnę?Mecenasi programu:Inwestuj w fundusze ETF z OANDA TMS Brokers: https://go.tms.pl/UkladOtwartyETF AMSO-oszczędzaj na poleasingowym sprzęcie IT: https://amso.pl/Uklad-otwarty-cinfo-pol-218.htmlNovoferm: https://www.novoferm.pl/ Zgłoś się do Szkoły Przywództwa Instytutu Wolności:https://szkolaprzywodztwa.plhttps://patronite.pl/igorjanke ➡️ Zachęcam do dołączenia do grona patronów Układu Otwartego. Jako patron, otrzymasz dostęp do grupy dyskusyjnej na Discordzie i specjalnych materiałów dla Patronów, a także newslettera z najciekawszymi artykułami z całego tygodnia. Układ Otwarty tworzy społeczność, w której możesz dzielić się swoimi myślami i pomysłami z osobami o podobnych zainteresowaniach. Państwa wsparcie pomoże kanałowi się rozwijać i tworzyć jeszcze lepsze treści. Układ Otwarty nagrywamy w https://bliskostudio.pl
I contenuti di questo video hanno solo finalità informative e si basano su fonti giornalistiche pubbliche disponibili al momento della registrazione. Non costituiscono giudizi personali né accuse.Support this podcast at — https://redcircle.com/storia/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Nei momenti di turbolenza con i nostri figli, la reazione istintiva è spesso agitarsi, urlare o cercare di farli smettere subito.Ma cosa succederebbe se imparassimo a restare centrati e calmi, proprio come una hostess in mezzo alle turbolenze?In questo episodio ti spiego, dal punto di vista pedagogico e neuroscientifico, perché la nostra calma è la chiave per farsi ascoltare dai bambini, come funziona il contenimento emotivo e come trasformare le crisi quotidiane in momenti di fiducia e sicurezza.Se senti che vuoi smettere di sentirti travolta dalle turbolenze quotidiane e imparare finalmente a restare calma anche nei momenti più difficili…Allora la nuova edizione della Dolce Guida è esattamente quello che ti serve.Ma attenzione: i posti sono limitati e già molti genitori hanno risposto al richiamo.Non lasciare che scivoli via: entra ora e scopri strumenti concreti, passo dopo passo, per trasformare le crisi in momenti di connessione e sicurezza con i tuoi figli.
Clicca qui per iscriverti alla Masterclass gratuita: https://autc.pro/TSSita-pod?utm_source=spreaker&utm_medium=podit&utm_content=477&sl=spreaker-podit-477
È una strategia spesso sottovalutata dagli investitori impazienti, ma amatissima da chi punta a risultati solidi nel tempo e vuole dormire sonni tranquilli. “Chi non s'intende di economia non capisce affatto la storia”Ezra Pound Sigla di Eric Buffat Per chi vuole acquistare i libri, il cui ricavato andrà totalmente in beneficenza: https://www.amazon.it/kindle-dbs/entity/author/B08FF1ZFV9 Learn more about your ad choices. Visit megaphone.fm/adchoices
Prawdziwa strategia zaczyna się tam, gdzie zaczyna się wartość dla klienta. W tym odcinku pokazuję, jak zrozumienie przepływu wartości zmienia sposób myślenia o celu, przewadze i dopasowaniu organizacji do rzeczywistości.Nagranie audio zawiera część inspiracyjną tego odcinka podcastu. Jeżeli chcesz zobaczyć, jak przełożyć tę wiedzę na praktykę, zapraszam Cię do jego drugiej części. Cały odcinek dostępny jest w formie wideo na platformie Youniversity. JAK DZIAŁA TEN PODCAST?Część pierwsza w formie audio jest darmowa i dostępna dla wszystkich. Tu dzielę się wiedzą i swoim doświadczeniem. Jeżeli posiadasz abonament w Youniversity, możesz ją obejrzeć w wersji wideo razem z prezentacją i materiałami do pobrania.Część druga – „Pojęcia strategiczne w praktyce”, to wdrożenie krok po kroku, gdzie dokładnie pokazuję konkretne działania, narzędzia i metody do zastosowania w Twojej firmie. Ta część, wraz z całością odcinka, dostępna jest w formie wideo wyłącznie na platformie Youniversity.Jeśli chcesz nie tylko słuchać, ale rozwijać siebie, swój zespół i firmę, wejdź na https://youniversity.pl i wybierz abonament, który najlepiej pasuje do Ciebie. Od planu Learn za 99 zł miesięcznie, po zaawansowane programy AI dla Liderów i CEO.Wszystkie historyczne odcinki 1-164 dostępne są do odsłuchu na platformie Youniversity. Jeśli to, o czym mówię w podcaście, rezonuje z Tobą i chcesz przeprowadzić podobną transformację w swojej firmie – zapraszam Cię na bezpłatną konsultację z zespołem Leanpassion: https://leanpassion.pl/bezplatna-konsultacja/Radek Drzewiecki
#394 - Guide vs VenditoriSai che cosa mi succede ogni volta che apro Substack, o LinkedIn, o qualunque posto dove la gente pubblica roba? Mi sembra di entrare in un mercato pieno di venditori che gridano tutti la stessa cosa: “Ehi, guarda me! Ho trovato il metodo giusto per crescere, per scrivere, per vendere di più!”… quello che vedo è una foresta di “guru”, e nessuno che ti aiuta davvero a capire dove sei. Tutti ti mostrano il loro albero, ma nessuno la mappa della foresta.Guardi intorno e vedi un mare di consigli, metodi, strategie, ognuno scollegato dall'altro. Centinaia di voci che parlano tutte insieme, ma nessuna che ti aiuta a vedere il quadro intero. ...e quella sensazione sottile di non sapere più di chi fidarti.Il problema è che viviamo in un'epoca dove tutti vogliono apparire come esperti, e sono pochissimi quelli che vogliono illustrare, spiegare, far vedere oltre la superficie. Si preferisce sparare grosso, attirare attenzione, convincere, persuadere piuttosto che avere la pazienza e perseveranza necessaria per diventare delle guide fidate, dei consiglieri. Ecco, per me, il vero valore oggi sta lì: nel fare da ponte. Nel mettere insieme i pezzi che gli altri lasciano sparsi in giro.Poi c'è un'altra cosa che mi colpisce tantissimo. Oggi nessuno racconta da dove arrivano le proprie idee. Leggi certi autori, coach, consulenti… e ti viene da pensare che siano nati illuminati, tipo Buddha con un account Twitter.Ma dai! Tutti abbiamo imparato da qualcuno. Abbiamo avuto modelli, maestri, letture che ci hanno formato, idee che abbiamo seguito e poi buttato via. Solo che pochi lo dicono. E sai perché?Perché oggi c'è la paura che, se ammetti di aver preso ispirazione da qualcun altro, sembri meno “originale”. Come se la credibilità venisse solo dal dire “questo l'ho inventato io”.Io invece penso il contrario: la vera credibilità nasce da chi sa riconoscere da dove arriva. Quando mostri le tue influenze, quando racconti il tuo percorso, la gente non ti vede più come un “guru”,ma come un essere umano che ha pensato, esplorato, cambiato idea. Se tutti raccontassero non solo le proprie convinzioni, ma anche i passaggi che li hanno portati lì, le letture, gli errori, i maestri, cominceremmo a vedere le famiglie di pensiero, le tendenze e come si evolvono, i gruppi underground, gli eretici.E sai che ti dico? Proprio perché c'è tutto questo rumore, c'è una grandissima opportunità.Chi avrà il coraggio, e la pazienza, di mappare la foresta, invece di piantare un altro albero, diventerà una voce autorevole. Non per quello che sa, ma per come collega ciò che sa.Il curatore, oggi, è quello che legge dieci prospettive diverse e poi ti dice: “Ok, guarda, questi tre approcci in realtà si completano. Questi altri due si contraddicono. E qui, in mezzo, c'è lo spazio dove puoi creare qualcosa di tuo.” Il curatore non vende “il suo metodo”. Ti aiuta a capire i metodi.La curation, in fondo, aiuta a fare proprio questo: a chiarire come le cose, i concetti, le idee, gli approcci si collegano fra loro, liberandoci dalla necessità di avere un unico punto di vista, soluzione, certezza, e rimpiazzandolo con il piacere di una comprensione più profonda, la ricchezza di avere a disposizione più punti di vista, strade, soluzioni e quindi di un panorama più ampio. E quando le persone vedono che tu favorisci questo modo di guidare e aiutare gli altri, allora - facci caso - prestano molta più attenzione. E lo sai perché? Perché non sentono più di dover scegliere “chi ha ragione”, ma possono finalmente capire come stanno insieme le cose.Morale della favolaIn un mondo dove tutti vogliono apparire come esperti, il vero potere ce l'ha chi ha una visione e una conoscenza più ampia. Chi invece di dire “seguimi”, “fai quello che ti dico” ti dice “guarda questa mappa che ho creato”. Quindi, per come la vedo io, non è il tuo “metodo” che ti rende autorevole. Piuttosto è la tua capacità di spiegare agli altri come tutto si collega e quali sono le strade, i sentieri, le guide e gli attrezzi che - avendoli studiati e sperimentati - possono essere di aiuto nel raggiungere gli obiettivi che uno si è preposto. _______________Info Utili• Sostieni questo podcast:Entra in contatto con me, ottieni feedback, ricevi consigli sul tuo progetto onlinehttps://Patreon.com/Robin_Good• Musica di questa puntata:"May" by Birocratic disponibile su Bandcamp• Nella foto di copertina:Lello Mannu e Ludovico. Sardegna. 1 Settembre 2016.• Ascolta e condividi questo podcast:https://www.spreaker.com/show/dabrandafriendArchivio completo organizzato per temi:https://start.me/p/kxENzk/da-brand-a-friend-archivio-podcast• Seguimi su Telegram:https://t.me/RobinGoodItaliaInstagram channelMomenti di vita non in posa - cosa vedono i miei occhi:https://instagram.com/giggi_canali • Newsletter in Inglese:https://robingood.substack.com - Fuoco su costruire fiducia per chi fa l'imprenditore online.
Mitä tapahtuu, kun yrityksen johtoketju joutuu myrskyn silmään?Tässä jaksossa kasvuyrittäjä ja juristi Timo Lappi avaa OHJ-ketjun (omistajat, hallitus ja johto) toimintaa erikoistilanteissa.Miten luottamus säilyy, kun markkina muuttuu, ja miksi hallituksen puheenjohtajan tärkein tehtävä ei ole johtaa, vaan antaa muiden loistaa?Lappi kertoo myös tuoreen kirjansa Osakeyhtiön johtoketju (Alma, 2025) oivalluksista: Miten vallasta luopuminen voi vahvistaa yrityksen selkärankaa ja miksi hyvä hallitus ei koskaan “boardsplainaa”.
Dlaczego doskonałość biznesowa to nie strategia? Można być coraz lepszym, mieć świetne procesy i wyniki, a mimo to przegrywać. Bo doskonałość to nie wybór kierunku, tylko sposób jazdy. Posłuchaj, zanim kolejny raz nazwiesz doskonalenie strategią.Nagranie audio zawiera część inspiracyjną tego odcinka podcastu. Jeżeli chcesz zobaczyć, jak przełożyć tę wiedzę na praktykę, zapraszam Cię do jego drugiej części. Cały odcinek dostępny jest w formie wideo na platformie Youniversity.JAK DZIAŁA TEN PODCAST?Część pierwsza w formie audio jest darmowa i dostępna dla wszystkich. Tu dzielę się wiedzą i swoim doświadczeniem. Jeżeli posiadasz abonament w Youniversity, możesz ją obejrzeć w wersji wideo razem z prezentacją i materiałami do pobrania.Część druga – „Pojęcia strategiczne w praktyce”, to wdrożenie krok po kroku, gdzie dokładnie pokazuję konkretne działania, narzędzia i metody do zastosowania w Twojej firmie. Ta część, wraz z całością odcinka, dostępna jest w formie wideo wyłącznie na platformie Youniversity.Jeśli chcesz nie tylko słuchać, ale rozwijać siebie, swój zespół i firmę, wejdź na https://youniversity.pl i wybierz abonament, który najlepiej pasuje do Ciebie. Od planu Learn za 99 zł miesięcznie, po zaawansowane programy AI dla Liderów i CEO. Wszystkie historyczne odcinki 1-164 dostępne są do odsłuchu na platformie Youniversity. Jeśli to, o czym mówię w podcaście, rezonuje z Tobą i chcesz przeprowadzić podobną transformację w swojej firmie – zapraszam Cię na bezpłatną konsultację z zespołem Leanpassion: https://leanpassion.pl/bezplatna-konsultacja/Radek Drzewiecki
In questa diretta capirai se le 7 fonti di reddito sono una grande idea oppure un epic fail!Guarda la replica del webinar “L'immobiliare intelligente" per scoprire opportunità e rischi dell'investimento immobiliare.
I casi di successo in ambito startup sono una miniera di consigli utili per chi lavora in ambito insurtech o fintech. Abbiamo intervistato Andrea Battista, fondatore di Net Insurance. Siamo partiti dalla storia dell'azienda (raccontata nel libro Exit Strategy) per estrarne alcuni spunti utili a spiegare come si può fare innovazione insurtech.
Questo videopodcast ha uno scopo semplice, ma fondamentale: vedremo, infatti, in modo pratico e senza fronzoli, come orientarti nella sterminata pletora di ETF disponibili sul mercato.Se vuoi costruire una strategia di investimento sensata, semplice e sostenibile nel tempo, qui troverai una guida completa con i concetti fondamentali, le categorie principali di ETF azionari e obbligazionari, gli errori più comuni e qualche esempio operativo per iniziare o rivedere il tuo portafoglio.
Kolejna rozmowa z serii Politycy o geopolityce. Tym razem gościem jest Krzysztof Bosak, wicemarszałek Sejmu. Rozmawiamy o tym, czy Ukraina powinna być strategicznym partnerem Polski, jak Polska może budować swoje wpływy, gdzie jest jej miejsce. Poruszamy również temat roli Polski w procesie pokojowym i odbudowie Ukrainy oraz relacji z Niemcami i USA.(00:00) Wstęp(1:48) Jak mierzyć siłę państwa? Jaka jest pozycja i rola Polski w świecie?(28:06) Czy Ukraina powinna być partnerem strategicznym? Czy Ukraina wejdzie do struktur zachodnich?(50:40) Co z ukraińską armią po wojnie?(54:54) Jaki powinien być wpływ Polski na proces pokojowy? (1:05:33) Polski udział w odbudowie Ukrainy(1:14:51) Współpraca z państwami bałtyckimi i nordyckimi(1:36:22) Jak prowadzić relacje partnerskie z Niemcami? Reparacje(1:47:28) Relacje ze Stanami ZjednoczonymiMecenasi programu:Inwestuj w fundusze ETF z OANDA TMS Brokers: https://go.tms.pl/UkladOtwartyETF AMSO-oszczędzaj na poleasingowym sprzęcie IT: https://amso.pl/Uklad-otwarty-cinfo-pol-218.htmlNovoferm: https://www.novoferm.pl/ Zgłoś się do Szkoły Przywództwa Instytutu Wolności:https://szkolaprzywodztwa.plhttps://patronite.pl/igorjanke ➡️ Zachęcam do dołączenia do grona patronów Układu Otwartego. Jako patron, otrzymasz dostęp do grupy dyskusyjnej na Discordzie i specjalnych materiałów dla Patronów, a także newslettera z najciekawszymi artykułami z całego tygodnia. Układ Otwarty tworzy społeczność, w której możesz dzielić się swoimi myślami i pomysłami z osobami o podobnych zainteresowaniach. Państwa wsparcie pomoże kanałowi się rozwijać i tworzyć jeszcze lepsze treści. Układ Otwarty nagrywamy w https://bliskostudio.pl
Lo Sportello unico digitale rientra tra le iniziative previste dalla Strategia per il mercato unico digitalecon l'obiettivo di rispondere alle esigenze di maggiore mobilità dei cittadini e delle imprese europei. L'approfondimento di Ada Ciaccia
Jeśli myślisz, że Twoja firma ma strategię, prawdopodobnie się mylisz. Większość firm myli transformację z kosmetyką procesów. Tymczasem strategia to wybory, które decydują, czy Twoja firma przeżyje, czy zniknie. W tym odcinku pokazuję, czym naprawdę jest transformacja strategiczna – i dlaczego bez niej nie masz szans na przyszłość.Nagranie audio zawiera część inspiracyjną tego odcinka podcastu. Jeżeli chcesz zobaczyć, jak przełożyć tę wiedzę na praktykę, zapraszam Cię do jego drugiej części. Cały odcinek dostępny jest w formie wideo na platformie Youniversity. JAK DZIAŁA TEN PODCAST?Część pierwsza w formie audio jest darmowa i dostępna dla wszystkich. Tu dzielę się wiedzą i swoim doświadczeniem. Jeżeli posiadasz abonament w Youniversity, możesz ją obejrzeć w wersji wideo razem z prezentacją i materiałami do pobrania.Część druga – „Pojęcia strategiczne w praktyce”, to wdrożenie krok po kroku, gdzie dokładnie pokazuję konkretne działania, narzędzia i metody do zastosowania w Twojej firmie. Ta część, wraz z całością odcinka, dostępna jest w formie wideo wyłącznie na platformie Youniversity.Jeśli chcesz nie tylko słuchać, ale rozwijać siebie, swój zespół i firmę, wejdź na https://youniversity.pl i wybierz abonament, który najlepiej pasuje do Ciebie. Od planu Learn za 99 zł miesięcznie, po zaawansowane programy AI dla Liderów i CEO.Wszystkie historyczne odcinki 1-164 dostępne są do odsłuchu na platformie Youniversity. Jeśli to, o czym mówię w podcaście, rezonuje z Tobą i chcesz przeprowadzić podobną transformację w swojej firmie – zapraszam Cię na bezpłatną konsultację z zespołem Leanpassion: https://leanpassion.pl/bezplatna-konsultacja/Radek Drzewiecki
Come Netflix è riuscita a vincere sfruttando la PIRATERIA. Ascolta il podcast STORIE di BRAND - https://spotify.openinapp.co/zp15q Entra nel Canale TELEGRAM - https://t.me/storiedibrand Storie su YOUTUBE - https://www.youtube.com/@StoriediBrand Seguici su INSTAGRAM - https://www.instagram.com/storiedibrand/?hl=it Learn more about your ad choices. Visit megaphone.fm/adchoices
Małe grupy: teacherola.com/grupyIndywidualne lekcje: teacherola.com/wspolpracaW tym odcinku poznasz strategię, która naprawdę odmieni Twój angielski mówiony. Opowiem Ci historię, która świetnie pokazuje różnicę między biernym słuchaniem a prawdziwym mówieniem. Zrozumiesz, dlaczego nawet po latach nauki wciąż trudno Ci mówić i co zrobić, aby to w końcu zmienić.Dowiesz się:✔️ dlaczego samo słuchanie podcastów i oglądanie filmów nie wystarczy✔️ czym jest serce języka i dlaczego to nie jest ani gramatyka, ani słownictwo✔️ jak działa mój program Voice Loop i dlaczego codzienna praktyka w grupie jest przełomem✔️ jak wygląda proces uczenia się w Voice Loop: nagrania w WhatsAppie, feedback, rozmowy na żywo✔️ jak zwykłe rozmowy w hostelu w Berlinie mogą zmienić Twoją pewność siebie w angielskim
In questa diretta scopriremo perché serve una formula per decidere se puntare sul reddito o sul patrimonio!Guarda la replica del webinar “L'immobiliare intelligente" per scoprire opportunità e rischi dell'investimento immobiliare.
Strategia, audyt, automatyzacja, content - te słowa mogą paraliżować, ale tylko wtedy gdy mediami społecznościowymi zajmujemy się z doskoku. W kolejnym odcinku naszego Podcastu Sektor 3.0 chcemy oswoić świat social media. Zaczniemy od podstaw, by potem zadać pytania znacznie poważniejsze. Najważniejszy wniosek może paść jednak już teraz - gdy się przygotujemy to nam będzie lżej, a media społecznościowe będą mogły przynieść pożądany efekt.⏹️ W tym odcinku:00:00 Wprowadzenie do odcinka01:05 Strategie obecności w mediach społecznościowych05:42 Audyt i selekcja kanałów komunikacji08:24 Tworzenie wartościowych treści1:49 Spójność komunikacji w mediach społecznościowych14:50 Zarządzanie kryzysowe w social mediach17:32 Algorytmy a autentyczność treści20:34 Zwinne podejście do tworzenia treści24:28 Narzędzia wspierające działania w social mediach27:41 Rola sztucznej inteligencji w komunikacji30:48 Mierzenie efektywności działań w mediach społecznościowych34:28 Budowanie własnych kanałów komunikacji⏹️ Więcej przeczytasz na naszym Blogu: TUTAJ⏹️ SEKTOR 3.0 to przedsięwzięcie, które wspiera transformację cyfrową i wykorzystywanie nowych technologii w działaniach społecznie użytecznych. ⏹️ Więcej informacji znajdziesz na https://sektor3-0.pl/ oraz w naszych mediach społecznościowych: FB - https://www.facebook.com/sektor3.0IG - https://www.instagram.com/sektor_3LI - https://www.linkedin.com/company/sektor-3-0/
Mogło to nie umknąć Twojej uwadze, że we wrześniu nie wypuściliśmy jednego odcinka :) Przyczyna jest prosta - byliśmy mocno przeładowani i ostatnie tygodnie dały nam w kość. Przygotowywaliśmy i przeprowadziliśmy szkolenia, występowaliśmy na konferencji, a dodatkowo po prostu mieliśmy codzienną pracę i obowiązki domowe. Jednym słowem - totalny tetris w kalendarzu i kocioł w głowie. W tym odcinku rozmawiamy o niebezpieczeństwach przeginania z robotą i innymi zobowiązaniami, oraz jak sobie z tym radzić. Poznasz trzy metody, które nam pomagają, gdy już jest ciężko, oraz jak nie brać na siebie zbyt dużo. Z tego odcinka dowiesz się: - Jak nie brać na siebie za dużo? - Jakie 3 techniki pomogą Ci się ogarnąć? - Co zrobić gdy już jesteś przeładowany/a? Linki do materiałów, wersję video oraz transkrypt do tego odcinka znajdziesz na stronie:
C'è una sorta di nuova strategia della tensione che agita l'Europa e mette in allerta la Nato. Tutto è iniziato con lo sconfinamento di una flotta di droni russi nei cieli della Polonia, ma le provocazioni non si sono fermate lì e continuano ogni giorno. Oggi cerchiamo di capire cosa sta succedendo e come Mosca stia tentando di destabilizzare i Paesi europei. ... Per iscriverti al canale Whatsapp: https://whatsapp.com/channel/0029Va7X7C4DjiOmdBGtOL3z Per iscriverti al canale Telegram: https://t.me/notizieacolazione Qui per provare MF GPT ... Gli altri podcast: https://milanofinanza.it/podcast Musica https://www.bensound.com Learn more about your ad choices. Visit megaphone.fm/adchoices
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Twoja marka osobista już istnieje. Nawet jeśli nigdy o niej nie myślisz, ona już coś o Tobie mówi. Pytanie brzmi: czy to Ty ją świadomie kształtujesz, czy pozwalasz, by robili to za Ciebie inni?Dla wielu menedżerów i liderów budowanie marki osobistej brzmi jak dodatkowy obowiązek lub, co gorsza, sztuczna autopromocja.Być może zadajesz sobie pytania:„Czy na moim etapie kariery to jest w ogóle potrzebne?”, „Czy muszę zaczynać od sesji zdjęciowej i logo?”,„Jak to robić w zgodzie ze sobą, bez sztucznego podbijania zasięgów?”.Jeśli te wątpliwości brzmią znajomo, ten odcinek jest dla Ciebie.Joanna Cieślak-Ospalska odpowiada na najczęstsze pytania, które zadają sobie liderzy, i obala mity narosłe wokół personal brandingu.W tym odcinku dowiesz się m.in:Dlaczego właśnie na wysokim stanowisku świadome zarządzanie marką jest ważniejsze niż kiedykolwiek.Od czego zacząć pracę nad marką – poznasz proste ćwiczenia, które pomogą Ci zdefiniować swoje wartości, wyróżniki i to, jak chcesz być postrzegany przez zespół i rynek.Przestań pozwalać, by inni definiowali Twoją historię. Czas przejąć nad nią kontrolę.Umów szkolenie 1:1https://www.naffy.io/joanna-cieslakBądźmy w kontakcie!joanna@markaeksperta.onlinehttps://www.linkedin.com/in/joannacieslak/________O czym jest ten podcast?marka osobista, personal brand, personal branding, szkolenia, marka eksperta, LinkedIn, LinkedIn tips, planowanie, produktywność, cele, podsumowanie roku, marketing, marketing online,________O prowadzącej:JOANNA CIEŚLAK-OSPALSKAtrenerka, * strateżka marek osobistych * autorka dwóch podcastów: “Marka Eksperta Online” oraz “Opanuj LinkedIn”.Od ponad dwudziestu lat pokazuje, jak budować markę, wzmacniać wizerunek i stosować komunikację, która spójna jest z wartościami.Prowadzi szkolenia dot. marketingu online, personal brandingu oraz wystąpień publicznych.Współpracuje z firmami, fundacjami, stowarzyszeniami, osobami indywidualnymi i uczelniami.Jest wykładowczynią na studiach podyplomowych związanych z marketingiem: “Nowoczesny Marketing”, “Executive Marketing”. “Grafika i social media” na Uniwersytecie Merito.Wykłada również na studiach MBA w Wyższej Szkole Gospodarki w Bydgoszczy.Jest opiekunką merytoryczną studiów podyplomowych “Wystąpienia publiczne w biznesie” oraz “Podcasting w firmie” na Uniwersytecie Merito.Jest wykładowczynią na studiach podyplomowych na Uniwersytecie SWPSAutorka i prowadząca podcast Marka Eksperta Online, który dotyczy budowania marki osobistej, działań w Internecie oraz dobrej organizacji pracy; a także podcast “Opanuj LinkedIn”, w którym pokazuje, jak skutecznie działać na LinkedIn.Umów szkolenie 1:1https://www.naffy.io/joanna-cieslakBądźmy w kontakcie!joanna@markaeksperta.onlinehttps://www.linkedin.com/in/joannacieslak/________O czym jest ten podcast?marka osobista, personal brand, personal branding, szkolenia, marka eksperta, LinkedIn, LinkedIn tips, planowanie, produktywność, cele, podsumowanie roku, marketing, marketing online,________O prowadzącej:JOANNA CIEŚLAK-OSPALSKAtrenerka, * strateżka marek osobistych * autorka dwóch podcastów: “Marka Eksperta Online” oraz “Opanuj LinkedIn”.Od ponad dwudziestu lat pokazuje, jak budować markę, wzmacniać wizerunek i stosować komunikację, która spójna jest z wartościami.Prowadzi szkolenia dot. marketingu online, personal brandingu oraz wystąpień publicznych.Współpracuje z firmami, fundacjami, stowarzyszeniami, osobami indywidualnymi i uczelniami.Jest wykładowczynią na studiach podyplomowych związanych z marketingiem: “Nowoczesny Marketing”, “Executive Marketing”. “Grafika i social media” na Uniwersytecie Merito.Wykłada również na studiach MBA w Wyższej Szkole Gospodarki w By
W dzisiejszym odcinku dołącza do nas Piotr Klin, aby opowiedzieć o narzędziach pomocnych w planowaniu startów. Zanim jednak przejdziemy do takich aplikacji jak Best Bike Split, My Windsock czy tabele Danielsa, pokażemy Wam, co ciekawego wydarzyło się w ostatnim tygodniu na triathlonowych i kolarskich trasach. Zdradzimy, jaki sprzęt zwrócił naszą uwagę, kto jest na fali, kto przeżywa słabsze chwile, a kto okazał się małym kłamczuszkiem. Mamy nadzieję, że oglądanie i słuchanie sprawi Wam tyle przyjemności, ile nam dało nagrywanie tego odcinka!00:00 Wprowadzenie do podcastu00:35 Analiza wyścigów i wyników Pogaczara03:24 Ostatnie zawody i ich przebieg08:36 Dramat Haydena Wilda i kontrowersje sprzętowe24:55 Smutne statystyki zawodów T10025:50 Krytyka wyścigów i tras26:01 Analiza testów sprzętu w Silverstone GTN27:52 Wątpliwości dotyczące testowania sprzętu29:30 Wyważenie kół i jego znaczenie32:28 Nowe technologie w rowerach triathlonowych36:08 Szczegóły dotyczące sprzętu Laidlowa43:09 Mistrzostwa Świata w Kigali i polskie osiągnięcia44:32 Sekrety sprzętu kolarskiego47:30 Innowacje w kaskach i butach50:20 Decyzje sprzętowe na mistrzostwach53:34 Promocja kolarstwa w egzotycznych krajach59:13 Weryfikacja umiejętności na trasie01:05:48 Aplikacje wspierające przygotowania do startu01:05:53 Wprowadzenie do MyWindsock i jego funkcji01:09:06 Analiza tras i prognozowanie warunków01:13:56 Porównanie MyWindsock z Best Bike Split01:16:31 Ustawienia profilu i analiza danych01:22:12 Praktyczne zastosowanie danych w treningu01:28:52 Analiza danych i modelowanie01:34:43 Strategia na Marbelle01:37:56 Tabela Danielsa i jej zastosowanie01:43:22 Zakończenie i podsumowanie
Viviana Mazza racconta che cosa ha detto il presidente Usa nel suo discorso all'Assemblea generale delle Nazioni Unite. Federico Fubini spiega che cosa si nasconde dietro l'attacco ibrido a Danimarca e Norvegia, che rivela un'intenzione chiara da parte della Russia (che però smentisce). Giusi Fasano ricostruisce come si è arrivati alla sentenza di primo grado nei confronti del figlio del fondatore dei 5 Stelle e di suoi tre amici, per violenza sessuale di gruppo.I link di corriere.it:Il discorso di Trump all'Onu: «L'Ue deve smettere di comprare gas da Mosca. Il cambiamento climatico è una truffa»Droni su Danimarca e Norvegia: perché riguarda la guerra in Ucraina (e il ruolo di Mosca, anche se smentisce)Ciro Grillo e due amici condannati a 8 anni, sei anni e sei mesi al quarto imputato
STRATEGIA DELLA TENSIONE? - FAUSTO CAROTENUTODiventa un supporter di questo podcast: https://www.spreaker.com/podcast/border-nights--654467/support.
Alexis #saelemaekers si sta prendendo (ancora una volta) il #milan : le strategie per il rinnovo di contrattoDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.
Host Dr. Shannon Westin and guest Dr. Hani Babiker discuss the JCO article "Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study." TRANSCRIPT TTFields in Locally Advanced Pancreatic Adenocarcinoma Dr. Shannon Westin: Hello everyone, and welcome to another episode of JCO After Hours, the podcast where we get in depth with manuscripts that have been published in the Journal of Clinical Oncology. I am your host, gynecologic oncologist Shannon Westin, social media editor at the JCO, and just excited to be here to learn today about pancreatic cancer. None of our participants have conflicts of interest related to this podcast, and it is my honor to introduce Dr. Hani Babiker. He is an associate professor of medicine, consultant in oncology at the Mayo Clinic in Jacksonville, Florida. Welcome, Dr. Babiker. Dr. Hani Babiker: Hi, Dr. Westin. Thank you for the great opportunity to discuss our trial, and thank you for having me here. I really appreciate it, and I am excited. Dr. Shannon Westin: All right, so are we. So we are going to be talking about “Tumor Treating Fields with Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: A Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study.” This was simultaneously published and presented in the JCO and at the annual meeting of ASCO on 5/31/2025. So, let's level set. Can you speak to us just a little bit about pancreatic cancer? What is the survival, and what is the typical treatment for locally advanced disease? This gynecologic oncologist has not kept up in this field. Dr. Hani Babiker: Absolutely, Dr. Westin, and thank you for that question. Pancreatic adenocarcinoma is a lethal cancer. When I first started my career, the 5-year survival, per the Surveillance, Epidemiology, and End Results, was at 4.5%. I always, whenever I was giving talks, say that I really hope that I will see it in the double digit. Now, the 5-year survival for all pancreatic adenocarcinoma is 13.3%. And the 5-year survival, and although it is a double digit, I still hope that I will see it in a higher double digit in the future. It is even worse in patients with metastatic cancer, about 3% 5-year survival for metastatic pancreatic cancer. It is a dismal diagnosis. I really hope in the future we will find a better therapeutic approach to this lethal cancer. Dr. Shannon Westin: Yes, I just lost a very dear friend and colleague to this disease, so I completely agree with you. Well, now that we are settled kind of with the basics here, I would love to talk a little bit about kind of the primary piece of this intervention, the Tumor Treating Fields. So, how does this work? And what diseases has it gotten indications in as yet? Dr. Hani Babiker: Absolutely. So, Tumor Treating Fields is alternating frequency electrical fields that have been studied preclinically and shown that it abrogates cancer cell proliferation. Earlier on, we knew that it inhibits polymerization of tubulin, and hence, it affects cancer cells from proliferating. Later, we are learning that there are multiple mechanisms of action. It affects permeability, allowing for better drug delivery. It also inhibits cancer cell proliferation through affecting autophagy mechanisms that pancreatic cancer cells will use for proliferating and becoming more aggressive. There is also some early data preclinically in colorectal cancer cell lines and lung cancer cell lines and in vivo models showing that it potentially could activate the microenvironment to make it more pro-immunogenic. We recently published papers showing that it could also affect the nanomechanical properties of the tumor microenvironment within pancreatic cancer, hinting towards affecting, potentially, the stroma. So, there are multiple mechanisms to Tumor Treating Electric Fields. It is a new, novel therapeutic approach. Sometimes when I speak with my trainees, I say, "Well, we have surgery, we have radiation and chemotherapy, and this is something new." Tumor Treating Fields initially was studied in refractory GBM and got an indication there. Subsequently, frontline treatment of GBM in a randomized clinical trial, and then malignant pleural mesothelioma and non-small cell lung cancer. We have studied it in pancreatic cancer. Dr. Shannon Westin: I don't think I have ever heard it described so perfectly. That was brilliant. So thank you, and I hope everyone listening knows that you just got a masterclass on this mechanism. You know, they dabbled in it a little bit in ovarian cancer and it didn't quite make the grade, so I was a little definitely disappointed. But very excited about the data we're going to talk about today. So let's get into the PANOVA-3 study. Can you highlight the overall design and also the key eligibility criteria that would be helpful for our listeners? Dr. Hani Babiker: Absolutely. So, it started off with preclinical work in pancreatic cancer showing Tumor Treating Fields with chemo abrogate cancer cell perforation. It led to a trial, the PANOVA-2 trial, that was run in Europe that showed efficacy for OS and PFS in patients with locally advanced pancreatic cancer, which included metastatic and locally advanced pancreatic cancer, more so in locally advanced that led to the PANOVA-3 trial, which was an international, global study. This was in more than 190 centers, 20 countries in Latin America, North America, Europe, and Asia. It was a randomized trial. Patients were randomized 1 to 1 to either chemotherapy with gemcitabine plus nab-paclitaxel per drug label. The other arm was with Tumor Treating Fields at 150 kHz for a recommendation for patients to wear it 18 hours per day. The primary end point of the trial was OS, overall survival. The secondary end point included other efficacy landmarks such as local PFS, pain control, quality of life, and safety. And there was a post hoc that looked at distant PFS. Dr. Shannon Westin: That's a pretty common secondary end point in pancreatic studies of looking at the pain-free interval. I thought that was really brilliant because, you know, I think in gyn cancers, we see resolution of symptoms as being a really big deal, but it's not necessarily something that we always look at. So I thought that was really nice that you included that. Okay, talk to us a little bit about the population. So, the population that actually got treated in PANOVA-3 is pretty generalizable to what people are treating in the clinic. Dr. Hani Babiker: So, in pancreatic cancer, unfortunately, most of our patients present, approximately 80%, with metastatic disease. Local is divided to resectable, borderline, and locally advanced. We studied this trial, a randomized trial, in locally advanced and unresectable, which is really an unmet need. Most of our patients with locally advanced and unresectable are grouped up with other trials in the metastatic setting without a focus on locally advanced and unresectable, save for a few trials. This year, a trial that we were looking for for a long time, the LAPLACE trial, unfortunately, that we were very excited about, this is a molecule that targeted connective tissue growth factor, that showed earlier efficacy in a randomized trial, did not meet up the median OS end point. And hence, PANOVA-3 is the first trial in locally advanced and unresectable that did meet its primary end point. So, it's a very unmet need in locally advanced and unresectable. A lot of the times, our patients in clinic are treated with frontline chemotherapy that was studied in metastatic disease and locally advanced and unresectable, which include either FOLFIRINOX, NALIRIFOX, or gemcitabine/abraxane. I do have in my clinic multiple patients that would stay on the regimen for such a long time, and then we would have to devise a mechanism of maintenance, although this is not studied really in details, either with capecitabine or dropping the oxaliplatin to continue FOLFIRI. And then we also approach chemoradiotherapy. So the trial was in a disease in pancreatic cancer that really is an unmet need. So the inclusion criteria included a patient with locally advanced and unresectable. These were done at multiple centers. Most of them academic centers were discussed at the tumor board, and if it's unresectable, they will be meeting specific metrics of appropriate liver function tests, kidney function tests, and blood counts. We excluded patients that obviously had, given that these are electric fields, patients that have, for example, stimulators or pacemakers, knowing that this could potentially affect some of these devices. But for the most part, it was locally advanced and unresectable patients with a very good performance status and good counts. Dr. Shannon Westin: That's great. I think everyone's excited to hear about the primary outcome of overall survival. What did you find, and how does it compare to some of the recent trials? Dr. Hani Babiker: We're very excited that it did meet its primary end point of median overall survival. It was very exciting knowing that a lot of us were disappointed a little bit of some of the trials that were presented at ASCO GI, such as the LAPLACE trial that I alluded to. Just before the presentation, the PRODIGE 29 trial that is in locally advanced and unresectable that randomized patients with locally advanced disease to either FOLFIRINOX or single-agent gemcitabine, allowing for a crossover, although it did meet its primary end point of PFS, there was no overall survival benefit. So that kind of got us a little bit disappointed, but having the PANOVA-3 trial being positive in median OS got us all excited. In addition, the 12-year overall survival rate was increased in both the intention-to-treat and modified intention-to-treat. The modified intention-to-treat were patients that have had at least one cycle of therapy with TTFields daily and/or one cycle with chemotherapy, which was gemcitabine plus nab-paclitaxel. There was a trend to improvement in PFS and local PFS, although that did not have statistical significance, but the 12-year PFS rate in both the intention-to-treat and modified intention-to-treat was significant. For me, as one of the investigators, that told me that there might be a specific biomarker that would tell me that patients could respond greater than others, more exceptional than others, given that 12-month PFS rate was improved. On a post hoc analysis, the distant PFS was improved with the intervention of Tumor Treating Fields with gemcitabine plus nab-paclitaxel. In addition, there was an improvement in global health status and quality of life in addition to pain-free survival, which is a strong hurdle in our patients with pancreatic adenocarcinoma that most present with significant abdominal pain. Dr. Shannon Westin: One of the other questions that I think has come up is around central review. So did you all use central review in this study? Dr. Hani Babiker: Most of the centers were academic centers. These were discussed in tumor boards, which included radiation oncologists and surgeons. I wanted to point out that it's very important to note that the primary end point was overall survival. So the primary end point was not PFS. Hence, the central review would help us, for example, with elaborating and making sure patients were actually locally advanced disease, but in a setting where the primary end point is overall survival, that was the key point of the clinical trial. This trial was discussed at academic centers, and all included tumor boards to decide if patients were locally advanced or not. In the trial, there was a good proportion of patients, or percentage, that had a CA 19-9 more than 1000. That could indicate that potentially there are a fraction of patients that actually had metastatic disease, micrometastatic disease. So that could hint towards why the median OS was slightly lower then in both arms when compared to, for example, the trial that was presented at ASCO GI, the LAPLACE trial. However, having said that, we were very excited about the trial. It was the first positive trial in locally advanced and unresectable to meet median OS survival. Dr. Shannon Westin: It's so awesome. So congratulations. Okay, so let's talk a little bit about your very detailed secondary end points because you had a lot of really prudent choices there. So anything that was interesting or informative in those end points? Dr. Hani Babiker: One major hurdle back we have for most of our patients with pancreatic adenocarcinoma, like I mentioned earlier, is pain. We try to approach it, obviously, with narcotics. If it doesn't work, we try to do celiac axis block interventionally, and that sometimes is successful and sometimes is not. So actually, to see the pain-free survival end point to be met was very exciting for us. And as for me, as a scientist that studies TTFields in clinic and lab as also to develop a mechanism and understanding really how that works. That was very important for us that in addition to chemotherapy, it improved pain-free survival or deterioration of pain. And most importantly, our patients with pancreatic cancer, this disease is very aggressive. It affects quality of life of patients. Patients feel fatigued, tired. It's a procoagulant tumor that causes clots and strokes, etcetera, marantic endocarditis. And one big problem we deal with when we're seeing patients in clinic is obviously that quality of life. Although data have shown with treatment, with frontline regimens, that quality of life improves with treatment and chemotherapy, it's actually great to see that that improvement happens early in addition to Tumor Treating Fields. The other interesting point was that it was not only pain and quality of life, but also digestive symptoms that are improved with this intervention, knowing that a lot of our patients do have pancreatic cancer, pancreatic exocrine insufficiency that affect also with digestion, and a lot of our patients have abdominal pain after eating and diarrhea. So it was interesting to see that also improved with the intervention. Dr. Shannon Westin: You have touched a little bit on some of the adverse events, kind of with the TT mechanisms, but I'd love to hear a little bit more detail around adverse events in general in this study, as well as specific AEs related to the Tumor Treating Fields. Dr. Hani Babiker: Absolutely. So when we compared both arms, there was a similar toxicity related to the regimen, mostly with chemotherapy, but in specifically to Tumor Treating Fields, there was a rash, and that included dermatitis and rash. Most of the side effects were grade 1 and grade 2. Grade 3 toxicities related to skin was less than 10%, approximately 7% to 8%, and hence did not affect many patients. But it was something to note, and it's something that in the future, when we develop a mechanism of treating patients to note early. We in our clinic have learned to treat patients in the clinical trial early with topical steroids to each patient, of shifting the arrays to mitigate some toxicity and rash. We do advise our patients in hot areas, we keep them aware that sweating, for example, can lead to higher conductivity of electrical fields with a predisposition for rash. So if there's an opportunity to stay in a little bit of a cold area, make sure that the arrays are shifted, use topical steroids early. If it's a significant rash, to hold treatment for at least 48 hours and speak to the investigators. And through these mechanisms, we have learned that we were able to mitigate the rash quite a bit. Dr. Shannon Westin: That's awesome. Thank you so much. Yeah, I'm, it's summer right now, and I think- I'm in Texas, you're in Florida, like we know. Okay, so I guess, again, you have been kind of touching on this, but I would love to know, like if in the quality-of-life assessments or if just in your discussions with patients, like how easy is this to use? How easy is the Tumor Treating Fields device to use, and what do patients really think? Dr. Hani Babiker: Absolutely. We have learned that whenever we speak with patients, it's always good to discuss with them briefly the science of it. A lot of patients would want to know if it's interventional, is that something that goes, is delivered percutaneously or not, and we explain that these are delivered through arrays that are through the skin. We always touch base with them about a lot of question I get about mechanism of action and then about compliance. So I think one important thing to note is that compliance with the use of the device is a lot of the question we'll get quite a bit. Patients know there's going to take an effort from them, and some of my patients enjoyed it because they felt like they also are fighting the disease by wearing the device. I have learned very quickly that having a team, surrounded by a team that knew how to mitigate some of the side effects and knew how to explain how to use the device helped quite a bit. And this included some of our nurses and our nurse practitioners and our clinical research coordinators who've done a wonderful job of showing these arrays actually to patients before they start on the trial, look at it, know how it works. The other point to know is that the sponsor provided Device Support Specialist, we call them DSS, they have been instrumental in helping us, helping the patients know how to use the device, how to use the generator, how to change the batteries, and that helped us conduct the trials and enroll very well. I would envision in the future with education and relying on the Device Support Specialist and having a team that knows how to use the device and mitigate some of the side effects will go a long way for patients to learn about this treatment. Many of the times our patients said while they are on the clinical trial felt like they are also being part of this team in applying the device and fighting the cancer. Dr. Shannon Westin: That's awesome. Well, I guess the bottom line. Is it ready for prime time? Is this something you are going to use for your patients in the clinic? Dr. Hani Babiker: Absolutely. In a disease that has poor prognosis, and we are trying our best to find new treatments to fight this cancer and treatment modalities, presenting patients with all the treatment options that are out there would be recommended. It's what I would do it for in my clinic. And you know, it's funny that I am mentioning that right now. I had a patient who was seen internationally asking about the trial and the device and had locally advanced and unresectable before they start frontline treatment. I do think that there is going to be an educational piece. Obviously, this is not a pill, it's not an intravenous chemotherapy that we're very well and accustomed to. And some of us in academic centers know it very well. I usually joke that whenever I am talking about it in pancreatic cancer, if there is a radiation oncologist in the room, they will be like, "Yeah, we know all about it. We have been treating patients with GBM over there." So a lot of the times, when we first went to trial, if I had any questions, I would call them and ask them. So from their perspective, they, because they use it as a standard of care in treatment of GBM, they develop significant expertise in it. I think in the GI world, specifically and with oncologists that treat pancreatic cancer and specifically oncologists in the community, learning about the device and how to use it, how to recommend it, how to mitigate side effects, will be hopefully for prime time in the future. Dr. Shannon Westin: That's great. Sounds like some real educational opportunities there. Well, this has been awesome. Thank you so much, Dr. Babiker. I mean, I learned a ton, and I wish that we could find a way to use this in gynecologic cancers, but really, really just want to commend you on the design of the trial and the success in this really devastating disease. So again, this was "Tumor Treating Fields with Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: A Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study." And as always, I am your host, Shannon Westin. Please go check out our other offerings wherever you get your podcasts and have an awesome day. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Dr. Babiker Disclosures Consulting or Advisory Role: Endocyte, Celgene, Idera, Myovant Sciences, Novocure, Ipsen, Caris MPI, Incyte, Guardant Health Speakers' Bureau: Guardant Health Research Funding: Spirita Oncology, Novocure, AstraZeneca, JSI, Incyte, Qurient, HiFiBiO Therapeutics, Revolution Health Care, Elevation Oncology, Dragonfly Therapeutics, Zelbio, BMS, Mirati Therapeutics, Strategia
Join Maximal Fire as we dive into the latest release for Legions Imperialis - the Liber Strategia! In this episode, we explore the new updates and strategic shifts in this latest expansion. Discover how detachments have changed, the impact of new iconic formations, and who the biggest winners and losers are in this game-changing update. Whether you're a veteran player or new to Legions Imperialis, this episode is packed with insights and tips. Join our vibrant community and share your thoughts on the latest changes. Subscribe now and stay ahead in the game! Blog and Articles: https://maximalfire.com/articlesWatch our other podcasts here! - https://www.youtube.com/playlist?list=PL82UVANZcT11sTvTQ3yzgKTVeYOcgTpg4 Additional podcast content - "The Noosphere" is available now through our Patreon located here: http://www.patreon.com/maximalfireOr join our new YouTube Members! https://www.youtube.com/channel/UCUrRZKbZ_dW4F3M-7ztFjWQ/joinhttp://maximalfire.comDiscord: https://discord.gg/5ruErzhsHaFacebook: www.facebook.com/maximalfireInstagram: @maximal.fireSponsored by EntoymentGet 10% off your first nameplate order with code "newbuilders" at https://www.BattleBuilder.netTimestamps:00:00:00 Intro00:19:20 The Preorder00:22:25 The Big Losers00:53:35 The Big Winners01:36:56 Final Thoughts#legionsimperialis #epicscale #summerpreview #warhammer #horusheresy #liberstrategia #maximalfireMusic:✘ Title: Killers✘ Music: Kevin MacLeod✘ License: CC BY 3.0 (http://goo.gl/BlcHZR)✘ Title: Suspense-war-teaser-ident-the-beginning-of-life-131572✘ Music: Alex Grohl✘ License: Pixabay ✘ Licensee: MaximalFire7
Episode 198– Liber Strategia and 'Terrain' GW sent us a preview copy of the new Legions book and as we explain in the episode we thought it was best to include our chat in the main episode. On top of that we have a little look at Terrain and Line of Sight rules in light of the current discussions going on. Guess what, we ramble a little bit as well, especially around the intro and news... 00:00:00 – 00:21:21 – Intro, Hobby, rambling 00:21:21 – 00:45:59 – News 00:45:59 – 01:43:42 – Liber Strategia 01:43:42 – 02:33:17 – Terrain and Line of Sight 02:33:17 – 02:37:09 – Closing the Show Teespring store: https://teespring.com/en-GB/stores/the-imperial-truth If you want to support the show then consider purchasing from Element Games. http://elementgames.co.uk/?d=10057 Don't forget you can use the codes for extra crystals. Greg – GRE259 Howard – HOW583 You can also support the Patreon here: https://www.patreon.com/TheImperialTruth Or via Ko-fi here: https://ko-fi.com/theimperialtruthfullstride If you enjoyed the show then please leave a positive review on Itunes. You can contact the show via Greg@TheImperialTruth.com You can follow us on Twitter: Show – @Imperial_Truth Greg – @ChildofFang Also our facebook page: https://www.facebook.com/the.imperial.truth.au And our facebook group https://www.facebook.com/groups/436768449815184/
Il #milan batte 9-0 il Perth Glory e chiude la tournée. Nel mentre sul #calciomercato tiene ancora banco la vicenda JashariDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.
(00:00:00) Quando l'ecosistema diventa strategia (00:00:13) Introduzione ai Servizi Apple (00:02:57) Apple Care è la number One (00:16:42) Apple diventa operatore? (00:22:55) Apple Intelligence Plus? (00:30:01) E ora? Secondo episodio dedicato ai servizi Apple: Jacopo riflette sull'importanza strategica di questa terza gamba per Cupertino, alla luce dei cambiamenti in atto su hardware e software. A partire dal lancio di AppleCare One – la nuova formula assicurativa che abbraccia l'intero ecosistema – analizziamo il senso della continuità, dell'integrazione e dell'evoluzione del concetto di servizio in stile Apple. Non manca uno sguardo verso il futuro: dall'ipotesi di Apple come operatore mobile alla connessione via satellite, fino ai servizi che potrebbero davvero cambiare le regole del gioco.Visita Digiteee e scopri tutte le notizie sulla tecnologiaSegui Digiteee su TikTokDimmi la tua su Twitter, su Threads, su Telegram, su Mastodon, su BlueSky o su Instagram.Mail jacoporeale@yahoo.it Scopri dove ascoltare il podcast e lascia una recensione su Apple Podcast o Spotify.Ascolta An iPad guy su YouTube Podcast.Supporta il podcast
The Summer Preview brought new units and books for Legions Imperialis! Here's what we think is in store for us!Additional podcast content - "The Noosphere" is available now through our Patreon located here: http://www.patreon.com/maximalfirePlease consider supporting the cast through our Patreon including access to a Private Discord Channel and 10% off Battle Bling products! - Patreon: http://www.patreon.com/maximalfireOr join our new YouTube Members! https://www.youtube.com/channel/UCUrRZKbZ_dW4F3M-7ztFjWQ/joinhttp://maximalfire.comDiscord: https://discord.gg/5ruErzhsHaFacebook: www.facebook.com/maximalfireInstagram: @maximal.fireSponsored by Entoyment, Battle Bling, Grim Dark terrain and Troublemaker Games!Get 10% off your first nameplate order with code "newbuilders" at BattleBuilder.net!BattleBuilder: https://www.battlebuilder.netBattle Bling Affiliate Link: https://battleblingstore.co.uk/?ref=gadzxp8qGet your Maximal Fire Merch from Redbubble! https://www.redbubble.com/people/Maximalfire/shop?asc=u00:00:00 Intro00:02:07 The Summer Preview00:08:57 Legions Imperialis Preview00:10:56 Liber Strategia00:50:00 Whirlwinds and Scorpius00:55:57 Vindicators01:00:32 Cerberus Tank Destroyers01:03:09 Typhon Siege Tanks01:09:02 Mastadon01:16:11 Tokens01:17:51 Hobby Chat01:23:16 Final ThoughtsMusic:✘ Title: Killers✘ Music: Kevin MacLeod✘ License: CC BY 3.0 (http://goo.gl/BlcHZR)✘ Title: Suspense-war-teaser-ident-the-beginning-of-life-131572✘ Music: Alex Grohl✘ License: Pixabay ✘ Licensee: MaximalFire7
Potrzebujesz wsparcia w stworzeniu strategii marketingowej? Sprawdź na https://marketingopanowany.pl/ jak możemy pomóc.—Wszyscy słyszeliśmy, że marketing powinien mieć strategię. Ale co to właściwie znaczy? To strasznie popularne słowo, które jednocześnie jest często źle rozumiane. W tym odcinku zebrałem 6 rzeczy, które warto wiedzieć zanim podejdziesz do tworzenia strategii marketingowej w Twojej firmie.Dowiesz się:✅ Jakie błędy popełniamy, gdy zabieramy się do tworzenia strategii marketingowej?✅ Jakie jedno słowo najlepiej podsumowuje strategię marketingową?✅ Jak wykorzystać AI do wdrożenia strategii marketingowej?✅ W jakiej formie zapisywać strategię, żeby była użyteczna?✅ Co jest potrzebne do stworzenia strategii marketingowej?✅ Czym jest, a czym nie jest strategia marketingowa?✅ Jak przejść od strategii do konkretnych działań?✅ Kto powinien tworzyć strategię marketingową?Ten odcinek jest dla Ciebie, jeśli jeśli myślisz o stworzeniu strategii marketingowej i chcesz przejść przez ten proces bez problemów i błędów.Nazywam się Jacek Kłosiński, a więcej o mnie i mojej firmie znajdziesz na https://marketingopanowany.pl/SPIS TREŚCI: 00:00 Wprowadzenie 01:40 Czym nie jest strategia marketingowa 03:05 Jedno słowo, które najlepiej opisuje strategię marketingową 06:03 Od czego zacząć prace nad strategią marketingową 08:00 Co pomaga tworzyć strategię marketingową 11:24 Kto powinien przygotować strategię marketingową 14:25 Jak praktycznie opisywać strategię marketingową 18:26 Podsumowanie
Sylwia Czubkowska jest dziennikarką, reporterką, od wielu lat zajmuje się tematami technologicznymi. Rozmawiamy o jej książkach, pasji do opisywania świata i ciekawości ludzi. Jej dwie niezwykłe książki „Chińczycy trzymają nas mocno” i „Bóg Techy” to szalenie ciekawe spojrzenia na świat przez pryzmat niezwykłych historii i ludzkich przeżyć. Pierwsza książka was przerazi tak, że pojawi się gęsia skórka, druga wejdzie do waszego domu w nocy, zrobi raban i wyrzuci wszystkie rzeczy z waszej szafy. Będzie trzeba wszystko poukładać, ale to nie jest złe. W pierwszej części rozmowy mamy opowieść o drodze świetnej dziennikarki, a w drugiej części rozmowy czeka was niespodzianka. Musicie posłuchać tej rozmowy, bo to są mega ważne tematy. Zmiany dzieją się ogromne. Podczas rozmowy z Sylwią Czubkowską poznałam nowe słowo infodenia – epidemia informacji. Ty też coś dla siebie znajdziesz. Rozdziały w rozmowie: 00:00 – Wstęp 01:54 – Dziennikarska droga Sylwii 11:34 – Bohaterowie książki „Chińczycy trzymają nas mocno” 15:37 – Strategia spowolnienia państwa – jak poruszają się big techy? 18:09 – Jak można zmienić swoje przyzwyczajenia? 25:05 – Musimy mieć podatek cyfrowy. 27:07 – Bonusowa rozmowa z Sylwią o książce „Bóg Techy” Dodatkowe materiały: Moja recenzja książki Sylwii Czubkowskiej: https://tiny.pl/0-h05f12 Moja rozmowa z Sylwią dla Magazynu Pod Prąd: https://youtu.be/eN2XWIdZVTk
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