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When Ellie Green left her house on the night of June 19, 2019, she thought she and her mother would continue their conversation the following day. However, Ellie says that she was shocked to discover that, just four days later, her father had her mother committed to a psychiatric hospital and she wouldn't be allowed to see her. She was even more shocked when, a month later, she says that she was told that her mother had died from a stroke while in the hospital. Devastated by her mother's death, Ellie wanted an explanation of how someone so young could suddenly die, but each question was met with vague and confusion answers. This was just the beginning of the mystery surrounding her mother's disappearance. If anyone has any information about Angela Green's disappearance, investigators urge them to call the TIPS Hotline at 816-474-TIPS. Information can also be sent to Steve Ridge directly at (319) 573-0657 or steveridge40@gmail.com. References Adler, Eric. 2023. "$25k reward offered for information on missing woman." Kansas City Star, March 4: 1. —. 2020. "'Dateline NBC' to explore case of missing Johnson County mom." Kansas City Star, October 29: 4. —. 2020. "Teen seeks truth of mom's mysterious disappearance." Kansas City Star, July 26: 1. —. 2022. "Three-year search from missing Prairie Village woman heats up." Kansas City Star, May 4: 10. 2026. People Magazine Investigates. Directed by Bruno Bahunek. Honeycutt, Sherae. 2020. Daughter of missing Prairie Village woman aching for answers as disappearance surpasses a year. February 26. Accessed August 18, 2026. https://fox4kc.com/news/exclusive-daughter-of-missing-prairie-village-woman-aching-for-answers-as-disappearance-surpasses-a-year/. —. 2020. Recorded phone calls involving missing Prairie Village woman's case raise more questions. October 29. Accessed August 19, 2026. https://fox4kc.com/news/recorded-phone-calls-involving-missing-prairie-village-womans-case-raise-more-questions/. Pelisek, Christine. 2026. A Mom Went Missing in 2019 After Arguing with Daughter. Her Husband Stopped Talking to Investigators a Long Time Ago. February 21. Accessed August 21, 2026. https://people.com/mom-vanished-2019-angela-green-daughter-wants-answers-11911133. Shriner, Zoe, and Betsy Weber. 2024. Five years since Prairie Village mom Angela Green disappeared without a trace. September 11. Accessed August 18, 2026. https://www.kctv5.com/2024/09/12/kc-unsolved-five-years-since-prairie-village-mom-angela-green-disappeared-without-trace/. Webster, Betsy. 2026. Private investigator claims new lead on Prairie Village mom's disappearance, police not yet informed. March 2. Accessed August 18, 2026. https://www.kctv5.com/2026/03/03/private-investigator-claims-new-lead-prairie-village-moms-disappearance-police-not-yet-informed/. Cowritten by Alaina Urquhart, Ash Kelley & Dave White (Since 10/2022)Produced & Edited by Mikie Sirois (Since 2023)Research by Dave White (Since 10/2022), Alaina Urquhart & Ash KelleyListener Correspondence & Collaboration by Debra LallyListener Tale Video Edited by Aidan McElman (Since 6/2025) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In this episode of Oncology On the Go, CancerNetwork® spoke with Frank McCormick, PhD, about the arc of KRAS-targeted drug development over his 40-year career. He explained why KRAS was long considered “undruggable.” He walked through the origins of the National Cancer Institute's RAS Initiative, which he helped lead starting in 2013, and how that effort produced several of the drugs now advancing through clinical trials for pancreatic cancer.A central moment of the conversation centers on the phase 3 RASolute-302 trial (NCT06625320) data, which showed that daraxonrasib nearly doubled overall survival compared with standard of care in pancreatic cancer. McCormick described this as a turning point that transformed pancreatic cancer from a historically difficult indication into one now seeing a wave of new drug development.McCormick also discussed his vision for cancer prevention. He described a roughly 20-year window between initiating KRAS mutations and clinical disease, and outlined a future in which a safe, well-tolerated KRAS inhibitor could be taken periodically to eliminate precancerous lesions before they progress, potentially preventing KRAS-driven cancers from developing at all.Additionally, he addressed practical considerations for treating clinicians: the feasibility of moving RAS inhibitors into earlier lines of therapy, and the biology oncologists, pharmacists, and genetic counselors should understand about differing KRAS allele subtypes.McCormick is a professor in the Helen Diller Family Comprehensive Cancer Center and holds the David A. Wood Distinguished Professorship of Tumor Biology and Cancer Research at the University of California, San Francisco (UCSF). He has researched KRAS for 40 years and helped lead the NCI RAS Initiative. He was recently named the inaugural recipient of the Stephenson Global Prize from the Stephenson Global Pancreatic Cancer Research Institute.ReferenceDaraxonrasib demonstrates unprecedented overall survival benefit in pivotal phase 3 RASolute 302 clinical trial in patients with metastatic pancreatic cancer. News release. Revolution Medicines Inc. April 13, 2026. Accessed August 19, 2026. https://tinyurl.com/44t5vh5d
After killing his family in the winter of 1971, John List went on the run, initiating a worldwide manhunt that would last nearly twenty years before he was finally apprehended. In that time, the List case would become one of the largest and most notorious investigations since the kidnapping of the Lindbergh baby. References Associated Press. 1972. "John List is still missing and local police are baffled." Courier-News (Bridgewater, NJ), February 22: 9. —. 1972. "Highjack-slaying ties denied." Press of Atlantic City, January 15: 4. Bailey, Bruce. 1972. "Worldwide hunt fails to find Wrstfield exec." The Star-Ledger (Newark, NJ), June 11: 1. Balog, Kathy. 1990. "The confession to his pastor was the most damning of all." The Courier-News (Bridgewater, NJ), April 13: 1. Benford, Timothy, and James Johnson. 1991. Righteous Carnage: The List Murders in Westfield. New York, NY: Scribner. Bullock, Marilyn, and Bruce Bailey. 1971. "The Lists were a neighborhood mystery." The Star-Ledger (Newark, NJ), December 9: 11. Chung, Connie. 2002. 1971 family killer breaks silence. February 20. Accessed August 1, 2026. https://abcnews.com/2020/story?id=132646&page=1. Cohen, Robert. 1971. "'Daddy, you're all I have left...'." The Star-Ledger (Newark, NJ), December 12: 1. —. 1971. "Husband hunted in mass slaying." The Star-Ledger (Newark, NJ), December 9: 1. Douthat, Strat. 1989. "The fugitive." Los Angeles Times, June 18: 2. Fiedler, Lore. 1973. "John List disappearance still unsolved." The Courier-News (Bridgewater, NJ), December 3: 11. —. 1971. "Westfielder sought in slaying of 5." The Courier-News (Bridgewater, NJ), December 8: 1. Hampton, Pat. 1980. "After 9 years, John List still a suspect-and still a mystery." The Courier-News (Bridgewater, NJ), December 6: 5. Hann, Christopher. 1989. "For stunned neighbors, news of arrest hits home." The Courier-News (Bridgewater, NJ), June 2: 7. LA Times Wire Service. 1989. "Suspect in family-slaying may be famed D.B. Cooper." Los Angeles Times, June 30. McNeel, John M. 1976. "What ever happened to John List." The Courier-News (Bridgewater, NJ), October 15: 11. Romano, Mary. 1989. "For the family, a chapter closes, a wound reopens." The Courier-News (Bridgewater, NJ), June 2: 1. Stout, David. 2008. "John E. List, 82, killer of 5 family members." New York Times, March 25. Sullivan, Joseph. 1990. "Slaying suspect saw 2 choices, doctor testifies." New York Times, April 7: 30. —. 1990. "Suspect wrote about killing family in '71." New York Times, March 29. Talmont, Tek, and Jill Vejnoska. 1990. "Attorney admits client is John List." The Courier-News (Bridgewater, NJ), February 15: 1. The Courier-News. 1990. "Two specialists describe List." The Courier-News (Bridgewater, NJ), April 10: 1. The Courier-Times. 1976. "Psychic gleaned varied impressions of List." The Courier-Times (Bridgewater, NJ), October 15: 11. Thompson, Robert. 1972. "List case unsoved after seven months." The Courier-News (Bidgewater, NJ), June 28: 1. Vejnoska, Jill. 1990. "Defense: List killed with love in his heart." The Courier-News (Bridgewater, NJ), April 3: 1. —. 1990. "Doctor recounts List's getaway." The Courier-News (Bridgewater, NJ), April 11: 1. —. 1990. "Doctor: Stressed List just snapped." The Courier-News (Bridgewater, NJ), April 7: 1. —. 1989. "FBI nabs John List." The Courier-News (Bridgewater, NJ), June 2: 1. —. 1990. "Letter: List shot family, prayed." The Courier-News (Bridgewater, NJ), March 29: 1. —. 1990. "List 'didn't trust God' to help him." The Courier-News (Bridgewater, NJ), April 6: 1. —. 1990. "List guilty." The Courier-News (Bridgewater, NJ), April 13: 1. —. 1989. "Prime-time spotlight focuses on long-time fugitve John Lisr." The Courier-News (Bridgewater, NJ), May 22: 1. —. 1989. "Westfield cops hope TV can help catch John List." The Courier-News (Bridgewater, NJ), April 14: 1. Wirt, George. 1977. "5-Year hunt: Cops 'haven't forgotten' slaughter of famil." The Star-Ledger (Newark, NJ), May 30: 10. Yates, Terry, and Robert Thompson. 1971. "'Nobody knew them too well'." The Courier-News (Bridgewater, NJ), December 8: 1. Cowritten by Alaina Urquhart, Ash Kelley & Dave White (Since 10/2022)Produced & Edited by Mikie Sirois (Since 2023)Research by Dave White (Since 10/2022), Alaina Urquhart & Ash KelleyListener Correspondence & Collaboration by Debra LallyListener Tale Video Edited by Aidan McElman (Since 6/2025) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Is your FYP and Instagram feed full of brightly colored decorations, furniture, and art? Are you finding yourself drawn to funky shaped furniture, maximalism, and painted doors? Boy do we have the episode for you! Today, Marcelle leads us through a conversation all about the “dopamine decor” trend! Through adrienne maree brown's theory of pleasure activism, she and Hannah unpack dopamine science, homeownership amongst millennials, and why we turn to beauty when the world is hard.Related listening:Dopamine x Health Capitalism with Jesse MeadowsAthleisure x Optimization with Anne Helen PetersonPixar x Affective EconomicsWorks Cited:brown, adrienne maree. Pleasure Activism: The Politics of Feeling Good. Chico, CA: AK Press, 2019.Cancilla, Julia. “The Surprising Science Behind the Dopamine Decor Trend.” ELLE Decor. December 20, 2024. https://www.elledecor.com/design-decorate/trends/a63250266/dopamine-decor-trend/. Accessed August 4, 2026.Cullinane, Alice. 2025. “Dopamine Decor: Why People Are Getting a Happiness Hit from Homes.” BBC News. December 14, 2025. https://www.bbc.com/news/articles/ckg2j5l4q7wo. Accessed August 4, 2026.Lee, Ingrid Fetell. “Does Dopamine Decor Really Work?.” The Aesthetics of Joy. March 8, 2024. https://aestheticsofjoy.com/dopamine-decor/. Accessed August 4, 2026.Mirdamadi, Michael, and Joshua Gordon. “Millennials in the Canadian housing market: An intergenerational comparison.” Housing Statistics in Canada. Government of Canada. May 6, 2026. https://www150.statcan.gc.ca/n1/pub/46-28-0001/2026001/article/00001-eng.htm. Accessed August 4, 2026.***Music Credits:“Shopping Mall”: by Jay Arner and Jessica Delisle ©2020Used by permission. All rights reserved. As recorded by Auto Syndicate on the album “Bongo Dance”. Hosted on Acast. See acast.com/privacy for more information.
Is your FYP and Instagram feed full of brightly colored decorations, furniture, and art? Are you finding yourself drawn to funky shaped furniture, maximalism, and painted doors? Boy do we have the episode for you! Today, Marcelle leads us through a conversation all about the “dopamine decor” trend! Through adrienne maree brown's theory of pleasure activism, she and Hannah unpack dopamine science, homeownership amongst millennials, and why we turn to beauty when the world is hard.Related listening:Dopamine x Health Capitalism with Jesse MeadowsAthleisure x Optimization with Anne Helen PetersonPixar x Affective EconomicsWorks Cited:brown, adrienne maree. Pleasure Activism: The Politics of Feeling Good. Chico, CA: AK Press, 2019.Cancilla, Julia. “The Surprising Science Behind the Dopamine Decor Trend.” ELLE Decor. December 20, 2024. https://www.elledecor.com/design-decorate/trends/a63250266/dopamine-decor-trend/. Accessed August 4, 2026.Cullinane, Alice. 2025. “Dopamine Decor: Why People Are Getting a Happiness Hit from Homes.” BBC News. December 14, 2025. https://www.bbc.com/news/articles/ckg2j5l4q7wo. Accessed August 4, 2026.Lee, Ingrid Fetell. “Does Dopamine Decor Really Work?.” The Aesthetics of Joy. March 8, 2024. https://aestheticsofjoy.com/dopamine-decor/. Accessed August 4, 2026.Mirdamadi, Michael, and Joshua Gordon. “Millennials in the Canadian housing market: An intergenerational comparison.” Housing Statistics in Canada. Government of Canada. May 6, 2026. https://www150.statcan.gc.ca/n1/pub/46-28-0001/2026001/article/00001-eng.htm. Accessed August 4, 2026.***Music Credits:“Shopping Mall”: by Jay Arner and Jessica Delisle ©2020Used by permission. All rights reserved. As recorded by Auto Syndicate on the album “Bongo Dance”. Hosted on Acast. See acast.com/privacy for more information.
In early December 1971, after a month of watching the lightbulbs in the List house slowly burn out one after another, neighbors finally became concerned about the List family and called the Westfield, NJ police to report their suspicions. Acting on the calls, officers arrived at house on the morning of December 7 to perform a wellbeing check, and when no one answered the door, they managed to gain access to the house through a basement window. When they reached the first floor, the officers found the bodies of the List family—including the couple's three children—dead from gunshot wounds to the head they'd suffered a month earlier. Noticeably absent from the remains in the house were those of the family patriarch, John List. In his office, investigators discovered a letter List had written to the pastor of his local church, in which he claimed to have murdered his family in order to spare them the pain of living in a world he believed had become corrupt and morally bankrupt. References Associated Press. 1972. "John List is still missing and local police are baffled." Courier-News (Bridgewater, NJ), February 22: 9. —. 1972. "Highjack-slaying ties denied." Press of Atlantic City, January 15: 4. Bailey, Bruce. 1972. "Worldwide hunt fails to find Wrstfield exec." The Star-Ledger (Newark, NJ), June 11: 1. Balog, Kathy. 1990. "The confession to his pastor was the most damning of all." The Courier-News (Bridgewater, NJ), April 13: 1. Benford, Timothy, and James Johnson. 1991. Righteous Carnage: The List Murders in Westfield. New York, NY: Scribner. Bullock, Marilyn, and Bruce Bailey. 1971. "The Lists were a neighborhood mystery." The Star-Ledger (Newark, NJ), December 9: 11. Chung, Connie. 2002. 1971 family killer breaks silence. February 20. Accessed August 1, 2026. https://abcnews.com/2020/story?id=132646&page=1. Cohen, Robert. 1971. "'Daddy, you're all I have left...'." The Star-Ledger (Newark, NJ), December 12: 1. —. 1971. "Husband hunted in mass slaying." The Star-Ledger (Newark, NJ), December 9: 1. Douthat, Strat. 1989. "The fugitive." Los Angeles Times, June 18: 2. Fiedler, Lore. 1973. "John List disappearance still unsolved." The Courier-News (Bridgewater, NJ), December 3: 11. —. 1971. "Westfielder sought in slaying of 5." The Courier-News (Bridgewater, NJ), December 8: 1. Hampton, Pat. 1980. "After 9 years, John List still a suspect-and still a mystery." The Courier-News (Bridgewater, NJ), December 6: 5. Hann, Christopher. 1989. "For stunned neighbors, news of arrest hits home." The Courier-News (Bridgewater, NJ), June 2: 7. LA Times Wire Service. 1989. "Suspect in family-slaying may be famed D.B. Cooper." Los Angeles Times, June 30. McNeel, John M. 1976. "What ever happened to John List." The Courier-News (Bridgewater, NJ), October 15: 11. Romano, Mary. 1989. "For the family, a chapter closes, a wound reopens." The Courier-News (Bridgewater, NJ), June 2: 1. Stout, David. 2008. "John E. List, 82, killer of 5 family members." New York Times, March 25. Sullivan, Joseph. 1990. "Slaying suspect saw 2 choices, doctor testifies." New York Times, April 7: 30. —. 1990. "Suspect wrote about killing family in '71." New York Times, March 29. Talmont, Tek, and Jill Vejnoska. 1990. "Attorney admits client is John List." The Courier-News (Bridgewater, NJ), February 15: 1. The Courier-News. 1990. "Two specialists describe List." The Courier-News (Bridgewater, NJ), April 10: 1. The Courier-Times. 1976. "Psychic gleaned varied impressions of List." The Courier-Times (Bridgewater, NJ), October 15: 11. Thompson, Robert. 1972. "List case unsoved after seven months." The Courier-News (Bidgewater, NJ), June 28: 1. Vejnoska, Jill. 1990. "Defense: List killed with love in his heart." The Courier-News (Bridgewater, NJ), April 3: 1. —. 1990. "Doctor recounts List's getaway." The Courier-News (Bridgewater, NJ), April 11: 1. —. 1990. "Doctor: Stressed List just snapped." The Courier-News (Bridgewater, NJ), April 7: 1. —. 1989. "FBI nabs John List." The Courier-News (Bridgewater, NJ), June 2: 1. —. 1990. "Letter: List shot family, prayed." The Courier-News (Bridgewater, NJ), March 29: 1. —. 1990. "List 'didn't trust God' to help him." The Courier-News (Bridgewater, NJ), April 6: 1. —. 1990. "List guilty." The Courier-News (Bridgewater, NJ), April 13: 1. —. 1989. "Prime-time spotlight focuses on long-time fugitve John Lisr." The Courier-News (Bridgewater, NJ), May 22: 1. —. 1989. "Westfield cops hope TV can help catch John List." The Courier-News (Bridgewater, NJ), April 14: 1. Wirt, George. 1977. "5-Year hunt: Cops 'haven't forgotten' slaughter of famil." The Star-Ledger (Newark, NJ), May 30: 10. Yates, Terry, and Robert Thompson. 1971. "'Nobody knew them too well'." The Courier-News (Bridgewater, NJ), December 8: 1. Cowritten by Alaina Urquhart, Ash Kelley & Dave White (Since 10/2022)Produced & Edited by Mikie Sirois (Since 2023)Research by Dave White (Since 10/2022), Alaina Urquhart & Ash KelleyListener Correspondence & Collaboration by Debra LallyListener Tale Video Edited by Aidan McElman (Since 6/2025) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Urge urinary incontinence (UUI) places a significant emotional and physical burden on women affected. Sacral neuromodulation has been and remains a well-established implant-based therapy for UUI. The concept originated in the early 1970s from sacral anterior root stimulation research for neurogenic bladder, with human clinical trials beginning in 1982. Medtronic's InterStim device received FDA approval in 1997 for UUI, and in 1999 for urgency-frequency and nonobstructive urinary retention. This was a game changer for affected women. Now, as of August 5, 2026, the FDA has granted 510(k) clearance for a new, less invasive neuromodulation implant- placed in the ANKLE. This is the Revi Extend Implant system (BlueWind Medical). What was the phase 3 data on this? What does the “wearable controller device” look like? Listen in for details. 1. Lukacz ES, Santiago-Lastra Y, Albo ME, Brubaker L. Urinary Incontinence in Women: A Review. JAMA. 2017;318(16):1592–1604. doi:10.1001/jama.2017.121372. Amundsen CL, Sutherland SE, Heesakkers JPFA, et al. Three-year efficacy and safety of Revi implantable tibial neuromodulation from the pivotal OASIS study. J Urol. 2026;216(2):219-229. doi:10.1097/JU.00000000000050623. BlueWind Medical receives FDA 510(k) clearance for Revi Extend implant. News release. BlueWind Medical Ltd. August 5, 2026. Accessed August 5, 2026. https://www.businesswire.com/news/home/20260805290667/en/BlueWind-Medical-Receives-FDA-510k-Clearance-for-Revi-Extend-Implant
Eliza Fletcher left for what should have been another ordinary early morning run through the streets of Memphis, but within minutes, her routine took a terrifying and unimaginable turn. A beloved kindergarten teacher, devoted mother, and passionate runner, Eliza's disappearance sent shockwaves through her community and launched an urgent investigation that quickly captured international attention. As detectives raced against the clock, surveillance footage, forensic evidence, and one suspect's troubling past began revealing a story more disturbing than anyone could have imagined. In this episode, we trace Eliza's final morning, examine the investigation that unfolded, and explore the questions her case raised about violent offenders, public safety, and whether a devastating tragedy could have been prevented.Sources: True Crime Writers, “Four Minutes in a Parking Lot: The Murder of Eliza Fletcher”, True Crime News Weekly, June 29, 2026, https://truecrimesweekly.com/2026/06/29/four-minutes-in-a-parking-lot-the-murder-of-eliza-fletcher/, Accessed August 8, 2026 Saunders, Angel, “Man Who Kidnapped and Killed Eliza Fletcher During Her Morning Run Pleads Guilty, Gets Life”, People, October 28, 2026, https://people.com/man-who-kidnapped-killed-eliza-fletcher-during-her-morning-run-pleads-guilty-gets-life-8735773, Accessed August 8, 2026 CBS AP, “Man pleads guilty to kidnapping and killing Eliza Fletcher, Memphis teacher abducted during morning run”, CBS News, October 28, 2024, https://www.cbsnews.com/news/eliza-fletcher-murder-cleotha-abston-pleads-guilty-memphis-teacher-jogging/, Accessed August 8, 2026
On the afternoon of July 18, 1984, James Huberty left his apartment in the San Ysidro neighborhood of San Diego, California, and drove one block over to the nearby McDonalds. After walking through the door of the restaurant, Huberty raised his Uzi semi-automatic 9mm and began indiscriminately shooting at patrons, employees, and anyone else who happened to cross into his line of sight. At the time, and for decades after, the San Ysidro McDonalds massacre was the worst mass shooting in American history, with the shooter killing twenty-one people and injuring nearly two dozen others before being struck down by a sniper's bullet. The incident lasted over an hour, during which time San Diego police and SWAT members surrounded the building, but didn't enter the building until an hour after the shooting started, when Huberty was already dead. MENTIONED IN THIS EPISODE To Celebrate Ash's Birthday, get YOURSELF a gift! Visit THE SIRIUS XM STORE and save 25% with CODE: AshSale. Need international shipping?? Visit PODSWAG! References Ben-Ali, Russell. 1990. "After a long wait, monument is dedicated at Massacre site." Los Angeles Times, December 14. Corwin, Miles, and Tom Howlett. 1984. "Neighbors reall a man who never smiled." Los Angeles Times, July 19: 14. Crea, Jackie. 2025. Survivors remember San Ysidro McDonald's mass shooting. July 18. Accessed August 6, 2025. https://www.nbcsandiego.com/news/local/san-ysidro-mcdonalds-mass-shooting-40-years-later/3569489/. Cummings, Judith. 1984. "Neighbors term mass slayer a quiet but hotheaded loner." New York Times, July 20: 1. Freed, David. 1984. "21 die in San Diego massacre." Los Angeles Times, July 19: 1. Logan, Alan C., Jeffrey J. Nicholson, Stephen J. Schoenthaler, and Susan L. Prescott. 2024. "Neurolaw: Revisiting Huberty v. McDonald's through the Lens of Nutritional Criminology and Food Crime." Laws. 2016. 77 Minutes. Directed by Charlie Minn. New York Times. 1984. "Coast man kills 20 in rampage at a restaurant." New York Times, July 19: 1. Time-Life Books. 1993. Mass Murderers. Alexandria, VA: Time-Life Books. Weintraub, Daniel. 1984. "'That guy's gonna shoot you'." Los Angeles Times, July 20: 2. Cowritten by Alaina Urquhart, Ash Kelley & Dave White (Since 10/2022)Produced & Edited by Mikie Sirois (Since 2023)Research by Dave White (Since 10/2022), Alaina Urquhart & Ash KelleyListener Correspondence & Collaboration by Debra LallyListener Tale Video Edited by Aidan McElman (Since 6/2025) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
CardioNerds Drs. Dinu Balanescu, Billy-Joe Mullinax, and Mariana Garcia discuss systemic thrombolysis in pulmonary embolism with expert Dr. Allison Burnett. Audio editing by CardioNerds Academy intern, student doctor, Pace Wetstein. Pulmonary embolism is the third leading cause of cardiovascular death in the US, and high-risk PE carries a 30-day mortality risk as high as 30-50%. In this episode, we discuss the indications for systemic thrombolysis, including high-risk PE and cardiac arrest. We addressed how to appropriately select candidates for systemic thrombolysis, balancing the high risk of bleeding. Additionally, we discussed anticoagulation management and timing concurrent with lytic therapy, as well as the importance of multidisciplinary PERT teams. The 2026 American multi-society PE guidelines were published after this episode was recorded. Dr. Dinu Balanescu and Dr. Billy-Joe Mullinax are Co-chairs for the CardioNerds PE Series, developed in collaboration with the PERT Consortium. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Pulmonary Embolism PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Risk stratification is crucial in acute pulmonary embolism care. Based on the ESC 2019 guidelines, low-risk PE patients are those who are normotensive with no evidence of right ventricular dysfunction. Intermediate risk includes two categories: intermediate-low, with normotensive patients who have a high PE score with negative biomarkers, and intermediate-high risk, which has elevated biomarkers or signs of RV strain. High-risk PE includes hemodynamically unstable patients (SBP
On February 3, Nevin (Adams) and Fred (Reish) met with a very special group of third-party administrators. Recorded live at the SoFi Center (home of TGL, Tomorrow's Golf League), the podcasting pair dealt with some of the most timely and critical issues confronting retirement plan professionals at the Definiti-sponsored event. In Part 1, we covered:3(16)Pooled Employer Plans (PEPs)But in Part 2, we pivot to:CrytpocurrencyArtificial IntelligenceEpisode Resources:Cybersecurity | U.S. Department of LaborTips for Hiring a Service Provider with Strong Cybersecurity Practices | U.S. Department of LaborSettlement Struck in Consulting Actuarial Firm Data HackCourt (Again) Rebuffs Amended Data Breach SuitU.S. Department of Labor. “Artificial Intelligence and Worker Well-being: Principles for Developers and Employers.” Accessed August 13, 2024. In Web Archive, archived August 13, 2024. https://web.archive.org/web/20240813173652/https:/www.dol.gov/general/ai-principles Compass: Navigating AI in Retirement Plan AdministrationTop 10 Questions for Plan Committees - October Compass 10 Things [Vertical]Data and Security: The Current Frontier https://www.napa-net.org/news/2021/6/data-and-security-current-frontier/
As I've done the last couple of years, I once again flipped through historical papers to find fun Christmas stories for you to enjoy. And, make sure you listen all the way to the end because this episode includes a special Christmas gift from me to you.SOURCESAmtrakguy365. “CSX's Santa Train - An Appalachian Christmas Tradition.” YouTube. Accessed August 26, 2025. https://www.youtube.com/watch?v=0BnfR0IkJUw. Anderson, Lorena. “‘Guardian Angel' Aids Ridge Woman.” Paradise Post (Paradise, California), December 26, 1991. www.newspapers.com.Associated Press. “The Last In Appalachia - Christmas Comes Early .” The Daily Sentinel (Fitchburg, Massachusetts), December 6, 1973. www.newspapers.com.Stevens, Bryan. “Authors Recall the Time the Railroad -- and Santa Claus, Too -- Were Sued.” The Erwin Record (Erwin,Tennessee), December 21, 2022. www.newspapers.com.Willliamson, C.N., and A.M. Williamson. “Rosemary: In Search of a Father.” The Neenah Daily Times (Neenah, Wisconsin), November 3, 1907. www.newspapers.com.SOUNDS SOURCESAl Jolson. “I'll Say She Does.” www.pixabay.com/music.Lucille Hegamin and The Dixie Daisies. “Cold Winter Blues.” www.pixabay.com/music.Sophie Tucker. “Reuben Rag.” www.pixabay.com/music.
On June 28, 1914, Archduke Franz Ferdinand was assassinated in Sarajevo, Bosnia and Herzegovina, leading to the beginning of World War II. What else was being reported in newspapers on that same day?SOURCES“Archduke Franz Ferdinand of Austria.” Wikipedia, July 23, 2025. https://en.wikipedia.org/wiki/Archduke_Franz_Ferdinand_of_Austria. “Assassination of Archduke Franz Ferdinand.” Wikipedia, August 1, 2025. https://en.wikipedia.org/wiki/Assassination_of_Archduke_Franz_Ferdinand.“Buried Loot on Desert Island.” The Morning Tulsa Daily World (Tulsa, Oklahoma), July 17, 1921. https://www.treasurenet.com/threads/pinaki-island-treasure.566022/. “Did Franz Ferdinand's Assassination Cause World War I?” History.com, January 31, 2025. https://www.history.com/articles/did-franz-ferdinands-assassination-cause-world-war-i.“The Great Salem Fire of 1914 (U.S. National Park Service).” National Parks Service. Accessed August 5, 2025. https://www.nps.gov/articles/000/1914-fire.htm. “Great Salem Fire of 1914.” Wikipedia, February 17, 2025. https://en.wikipedia.org/wiki/Great_Salem_fire_of_1914. “A Hoax in Gold.” The Anaconda Standard (Anaconda, Montana), June 28, 1914. “Illness May Again Halt Angle Trial.” Bridgeport Evening Farmer (Bridgeport, Connecticut), December 1, 1914. www.newspapers.com.“Jury Declares Mrs. Angle Not Guilty.” The Commercial Appeal (Memphis, Tennessee), March 20, 1915. www.newspapers.com.Kainic, Pascal. “The Peruvian Lost Treasures.” Lost Treasures of the Seven Seas. Accessed September 2, 2025. http://www.oceantreasures.org/pages/content/world-of-shipwrecks/the-peruvian-lost-treasures.html.“Loot Angle Safe To Obtain Papers.” New York Tribune (New York City, New York), June 28, 1914. www.newspapers.com.“More than 154 Millions in Gold Lost at Sea or Buried on Lonely Isles.” The Kansas City Times (Kansas City, Missouri),February 9, 1934. www.newspapers.com.“Mrs. Angle Held By Coroner For Death of Waldo Ballou.” The Meriden Daily Journal (Meriden, Connecticut), July 28,1914. www.newspapers.com.“Mrs. Angle Tells Story How Waldo Ballou Died.” The Meriden Daily Journal (Meriden, Connecticut), March 16, 1915. www.newspapers.com.Rohe, Alice. “‘Ballou Best Friend I Had,' Woman Sobs.” The Buffalo Times (Buffalo, New York), June 25, 1914. www.newspapers.com.“Serb Student Assassinates Archduke and His Duchess.” The Washington Times (Washington D. C.), June 28, 1914. www.newspapers.com.“Stories of Recovery after the Great Salem Fire of 1914.” Preserving Salem. Accessed August 5, 2025. https://www.preservingsalem.com/salemfire1914. “The Treasure of Tuamotu - The Queenslander Illustrated Weekly (Brisbane, Qld. : 1927 - 1939) - 26 May 1937.” Trove.Accessed September 4, 2025. https://trove.nla.gov.au/newspaper/article/23588469. “Unburned Area of Salem Imperiled By Another Blaze.” Detroit Free Press (Detroit, Michigan), June 28, 1914. www.newspapers.com.“Woman Held In Murder Case.” The Evansville Journal (Evansville, Indiana), June 28, 1914. www.newspapers.com.SOUND SOURCESAl Jolson. “I'll Say She Does.” www.pixabay.com/music.Lucille Hegamin and The Dixie Daisies. “Cold Winter Blues.” www.pixabay.com/music.Sophie Tucker. “Reuben Rag.” www.pixabay.com/music.
Overview: In this episode, Toyin Nwafor, MD, and Christian B Ramers, MD, draw on their experience in primary care, HIV and HIV prevention to highlight missed opportunities for HIV prevention and discuss strategies to help address gaps in the HIV care continuum. The views expressed are those of the panelist(s) and not necessarily Gilead Sciences, Inc. The information provided in this podcast is not intended to be and should not be understood to provide medical advice. Listeners should note that our discussions in this episode are relevant to the USA only and may not be appropriate for other regions. This episode was recorded in August 2025 and the content reflects the information available at that time. Guest: Toyin Nwafor, MD; Christian B Ramers, MD, MPH, FIDSA, AAHIVS For more information, please visit: https://www.pri-med.com/clinical-resources/curriculum/hiv-in-focus References AIDSVu.org. Prevalence in the United States. 2022. Available from: https://map.aidsvu.org/ (Accessed June 25, 2025). AIDSVu.org was developed by the Rollins School of Public Health at Emory University in partnership with Gilead Sciences, Inc. Baeten J et al. Curr HIV/AIDS Rep 2013;10:142–51. CDC. Clinical testing guidance for HIV. 2025. Available from: https://www.cdc.gov/hivnexus/hcp/diagnosis-testing/index.html (Accessed June 25, 2025). CDC. Discussing sexual health with your patients. 2025. Available from: https://www.cdc.gov/hivnexus/hcp/sexual-history/index.html (Accessed June 25, 2025). CDC.gov. HIV diagnoses, deaths, and prevalence. 2025. Available from: https://www.cdc.gov/hiv-data/nhss/hiv-diagnoses-deaths-prevalence.html (Accessed June 25, 2025). CDC. National HIV prevention and care objectives: 2025 update. 2025. Available from: https://www.cdc.gov/hiv-data/nhss/national-hiv-prevention-and-care-objectives-2025.html (Accessed June 25, 2025). CDC. Preexposure prophylaxis for the prevention of HIV infection in the United States – 2021 update: a clinical practice guideline. 2021. Available from: https://stacks.cdc.gov/view/cdc/112360 (Accessed June 25, 2025). Doblecki-Lewis S et al. J Int Assoc Provid AIDS Care 2019;18:2325958219848848. DHHS. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. 2024. Available from: https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/adult-adolescent-arv/guidelines-adult-adolescent-arv.pdf (Accessed June 25, 2025). HIV.gov. Key EHE strategies. 2024. Available from: https://www.hiv.gov/federal-response/ending-the-hiv-epidemic/key-strategies (Accessed June 2, 2025). HIV.gov. HIV treatment as prevention. 2023. Available from: https://www.hiv.gov/tasp (Accessed June 25, 2025). HIV.gov. US statistics. 2025. Available from: https://www.hiv.gov/hiv-basics/overview/data-and-trends/statistics (Accessed May 21, 2025). HIV.gov. Viral suppression and undetectable viral load. 2025. Available from: https://www.hiv.gov/hiv-basics/staying-in-hiv-care/hiv-treatment/viral-suppression (Accessed July 18, 2025). HIV.gov. Who is at risk for HIV. 2025. Available from: https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/who-is-at-risk-for-hiv (Accessed June 25, 2025). Johns Hopkins Bloomberg School of Public Health. What to know about PrEP. 2025. Available from: https://publichealth.jhu.edu/2025/who-needs-prep-for-hiv-prevention (Accessed June 25, 2025). Kamis KF et al. Open Forum Infect Dis 2019;6:ofz310. KFF. HIV testing in the United States. 2024. Available from: https://www.kff.org/hiv-aids/hiv-testing-in-the-united-states/ting in the United States | KFF (Accessed August 26, 2025). NIH. HIV and sexually transmitted infections (STIs). 2021. Available from: https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-and-sexually-transmitted-infections-stis (Accessed June 25, 2025). Ramchandani MS et al. Curr HIV/AIDS Rep 2019;16:244–56. Saag MS et al. JAMA 2018;320:379–96. Sweeney P et al. J Acquir Immune Defic Syndr 2019;82(Suppl 1):S1–5. The White House. National HIV/AIDS strategy for the United States 2022–2025. 2021. Available from: https://files.hiv.gov/s3fs-public/NHAS-2022-2025.pdf (Accessed June 25, 2025). UNAIDS.org. Recommended 2030 targets for HIV. 2025. Available from: https://www.unaids.org/en/recommended-2030-targets-for-hiv (Accessed August 26, 2025). United States Census Bureau. National population by characteristics: 2020-2024. 2024. Available from: https://www.census.gov/data/tables/time-series/demo/popest/2020s-national-detail.html (Accessed June 25, 2025). United States Census Bureau. United States Population Growth by Region. 2025. Available from: https://www.census.gov/popclock/ (Accessed June 25, 2025). Yumori C et al. Sex Transm Dis 2021;48:32–6.
About this Episode Episode 50 of “The 2 View” – BNPs, D-Dimers, and Sneakily Sick Kids Segment 1A - Needs of older nurses Clendon JA, Walker L. Nurses aged over 50 and their perceptions of flexible working: The experiences and needs of older nurses in relation to flexible working and the barriers and facilitators to implementation within workplaces. J Nurs Manag. 2016;24:336-346. doi:10.1111/jonm.12325 Segment 1B - WHO and Tropical Diseases Special Programme for Research and Training in Tropical Diseases. World Health Organization. Accessed August 19, 2025. https://tdr.who.int/about-us Segment 2A - BNP Silvers SM, Gemme SR, Hickey S, et al. Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Heart Failure Syndromes. Ann Emerg Med. 2019;49(2): 232–241. Lamberta M, Chertoff A. BNP Level in the Emergency Department: Does it Change Management? EMDocs. June 20, 2016. Accessed November 4, 2025. https://www.emdocs.net/bnp-level-in-the-emergency-department-does-it-change-management/ Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002;347(3):161-167. doi: 10.1056/NEJMoa020233 Segment 2B - D-Dimer Wolf SJ, Hahn SA, Nentwich LM, et al. Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with suspected acute venous thromboembolic disease. Ann Emerg Med. 2018;71(5):e59–e109. doi:10.1016/j.annemergmed.2018.03.006 Righini M, Van Es J, Den Exter PL, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: The ADJUST-PE study. JAMA. 2014;311(11):1117–1124. doi:10.1001/jama.2014.2135 van der Hulle T, Cheung WY, Kooij S, et al. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): A prospective, multicentre, cohort study. Lancet. 2017;390(10091):289–297. doi:10.1016/S0140-6736(17)30885-1 Kearon C, de Wit K, Parpia S, et al. Diagnosis of pulmonary embolism with D-dimer adjusted to clinical probability. N Engl J Med. 2019;381(22):2125–2134. doi:10.1056/NEJMoa1909159 Lim w, Le Gal G, Bates SM, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Diagnosis of venous thromboembolism. Blood Adv. 2018;2(22):3226-3256. doi:10.1182/bloodadvances.2018024828 Kabrhel C, Jaff MR, Channick RN. D-dimer. StatPearls. June 22, 2025. Accessed November 4, 2025. https://www.ncbi.nlm.nih.gov/books/NBK431064/ Tripodi A, Lippi G. How we manage a high D-dimer. Haematologica. 2020;106(6):1491-1494. doi:10.3324/haematol.2020.248344 Segment 3: Sneakily Sick Kids Kocher MS, Zurakowski D, Kasser JR. Differentiating between septic arthritis and transient synovitis of the hip in children: An evidence-based clinical prediction algorithm. J Bone Joint Surg Am. 1999;81(12):1662-1670. doi:10.2106/00004623-199912000-00002 Caird MS, Flynn JM, Leung YL, et al. Factors distinguishing septic arthritis from transient synovitis of the hip in children: a prospective study. J Bone Joint Surg Am. 2006;88(6): 1251-1257. doi:10.2106/JBJS.E.00216 Recurring Sources Center for Medical Education. http://ccme.org The Proceduralist. http://www.theproceduralist.org The Procedural Pause. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. http://www.thesgem.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to.
Let's keep exploring the history of Essex Street! We spent part one strolling from Collins Cove to the Hawthorne Hotel. Part two brings us up a little further to the East India fountain and we cover everything that's packed in between--Salem's layered history of maritime, architecture, literature, and cinema continues. Join Sarah and Jeffrey, your favorite Salem tour guides, for another walk down Essex Street. We delve into the history of the Peabody Essex Museums properties, the long since gone armory, and while Cinema Salem is there today, what about the grand theater that used to be where the parking garage is now? Feel free to open google maps and walk with us as we start our journey. Google Maps. “Directions to 42.5261979,-70.8841083.” Google Maps. https://www.google.com/maps/dir//42.5261979,-70.8841083/@42.5249201,-70.8860927,17.1z/data=!4m2!4m1!3e2?entry=ttu&g_ep=EgoyMDI1MDkxMC4wIKXMDSoASAFQAw%3D%3D. Digital Commonwealth; Phillips Library at the Peabody Essex Museum. Search results for “Essex Street.” Digital Commonwealth. Accessed August 20, 2025. LINK. Hart, Donna Seger. “Envisioning Essex Street.” Streets of Salem (blog), January 11, 2011. Accessed August 21, 2025. LINK. Hart, Donna Seger. “Evolving Essex Street.” Streets of Salem (blog), June 22, 2015. Accessed August 22, 2025. LINK. Hart, Donna Seger. “First-Period Fantasy.” Streets of Salem (blog), March 18, 2018. Accessed August 20, 2025. LINK. Hart, Donna Seger. “On the Tavern Trail.” Streets of Salem (blog), August 20, 2019. Accessed August 21, 2025. LINK. Streets of Salem. “Essex Street.” Accessed August 22, 2025. LINK. History by the Sea. “Almshouse and Hospital for Contagious.” Accessed August 20, 2025. LINK. Leventhal Map & Education Center. Commonwealth: 0r96fn00f. Leventhal Map & Education Center. Accessed August 21, 2025. LINK. National Park Service. “Narbonne House.” Last modified March 30, 2022. LINK. The Naumkeag District Directory for Salem No. 3, 1886–1887. Salem, MA: Henry M. Meek, 1887. Patch. “History of Salem Movie Houses.” Salem Patch. Accessed August 22, 2025. LINK. Salem News. “Salem Eyes Two Options for Essex St. Pedestrian Mall.” The Salem News. Accessed August 20, 2025. LINK. Salem State Archives. “Salem State Archives Flickr Collection.” Flickr. Accessed August 21, 2025. LINK. Salem State University Archives and Special Collections. “Paramount Theatre.” Salem State University LibGuides.Accessed August 22, 2025. LINK. Interested in Salem The Podcast Merch!? CLICK HERE! Interested in supporting the Podcast? Looking for more Salem content? CLICK HERE! www.salemthepodcast.com NEW INSTAGRAM - @salemthepod Email - hello@salemthepodcast.com Book a tour with Jeffrey at Salem Uncovered Tours www.salemuncoveredtours.com Book a tour with Sarah at Bewitched Historical Tours www.bewitchedtours.com Intro/Outro Music from Uppbeat: https://uppbeat.io/t/all-good-folks/unfamiliar-faces License code: NGSBY7LA1HTVAUJE
Let's keep exploring the history of Essex Street! We spent part one strolling from Collins Cove to the Hawthorne Hotel. Part two brings us up a little further to the East India fountain and we cover everything that's packed in between--Salem's layered history of maritime, architecture, literature, and cinema continues. Join Sarah and Jeffrey, your favorite Salem tour guides, for another walk down Essex Street. We delve into the history of the Peabody Essex Museums properties, the long since gone armory, and while Cinema Salem is there today, what about the grand theater that used to be where the parking garage is now? Feel free to open google maps and walk with us as we start our journey. Google Maps. “Directions to 42.5261979,-70.8841083.” Google Maps. https://www.google.com/maps/dir//42.5261979,-70.8841083/@42.5249201,-70.8860927,17.1z/data=!4m2!4m1!3e2?entry=ttu&g_ep=EgoyMDI1MDkxMC4wIKXMDSoASAFQAw%3D%3D. Digital Commonwealth; Phillips Library at the Peabody Essex Museum. Search results for “Essex Street.” Digital Commonwealth. Accessed August 20, 2025. LINK. Hart, Donna Seger. “Envisioning Essex Street.” Streets of Salem (blog), January 11, 2011. Accessed August 21, 2025. LINK. Hart, Donna Seger. “Evolving Essex Street.” Streets of Salem (blog), June 22, 2015. Accessed August 22, 2025. LINK. Hart, Donna Seger. “First-Period Fantasy.” Streets of Salem (blog), March 18, 2018. Accessed August 20, 2025. LINK. Hart, Donna Seger. “On the Tavern Trail.” Streets of Salem (blog), August 20, 2019. Accessed August 21, 2025. LINK. Streets of Salem. “Essex Street.” Accessed August 22, 2025. LINK. History by the Sea. “Almshouse and Hospital for Contagious.” Accessed August 20, 2025. LINK. Leventhal Map & Education Center. Commonwealth: 0r96fn00f. Leventhal Map & Education Center. Accessed August 21, 2025. LINK. National Park Service. “Narbonne House.” Last modified March 30, 2022. LINK. The Naumkeag District Directory for Salem No. 3, 1886–1887. Salem, MA: Henry M. Meek, 1887. Patch. “History of Salem Movie Houses.” Salem Patch. Accessed August 22, 2025. LINK. Salem News. “Salem Eyes Two Options for Essex St. Pedestrian Mall.” The Salem News. Accessed August 20, 2025. LINK. Salem State Archives. “Salem State Archives Flickr Collection.” Flickr. Accessed August 21, 2025. LINK. Salem State University Archives and Special Collections. “Paramount Theatre.” Salem State University LibGuides.Accessed August 22, 2025. LINK. Interested in Salem The Podcast Merch!? CLICK HERE! Interested in supporting the Podcast? Looking for more Salem content? CLICK HERE! www.salemthepodcast.com NEW INSTAGRAM - @salemthepod Email - hello@salemthepodcast.com Book a tour with Jeffrey at Salem Uncovered Tours www.salemuncoveredtours.com Book a tour with Sarah at Bewitched Historical Tours www.bewitchedtours.com Intro/Outro Music from Uppbeat: https://uppbeat.io/t/all-good-folks/unfamiliar-faces License code: NGSBY7LA1HTVAUJE
In the early morning hours of July 9, 1993, police in Sedona, Arizona received a dispatch call from 911 regarding a domestic violence related shooting at a home on Coffee Pot Drive. When they arrived at the home, officers found thirty-one-year-old Russell Peterson performing CPR on his longtime girlfriend, Stephanie Wasilishin, who was lying on the floor of the couple's bedroom with a large hole in her neck from a .44 caliber bullet. Also present in the bedroom was the couple's four-year-old daughter.At first, Peterson told investigators that Stephanie had fired the gun at him in the living room, then retreated to the bedroom, where the two struggled over the gun, during which Stephanie was shot. Later, however, Peterson changed his story, telling detectives he couldn't remember what happened, but he thought Stephanie shot herself. Further complicating matters was the couple's daughter, who told detectives “Papa killed her.”For decades, the Wasilishin family has sought justice for Stephanie, but that justice and the answers to their questions have remained elusive. With the passage of time, is it possible for investigators to close the case on Stephanie Wasilishin's death, or has too much time passed for a resolution to present itself?Looking to sign the petition? Click here!Want LISTEN to Nikki's Podcast “PAPI KILLED MOMMY” Listen here!Follow Nikki on TikTok Click here!Thank you to the Amazing Dave White (of BRING ME THE AXE PODCAST) for research and writing assistance!ReferencesBrooks, Scott. 1993. Miscellaneous offense report, Peterson/Wasilishin. Incident Report, Sedona, Arizona: Sedona Police Department.Eland, Ron. 2020. Sedona Police Department adds more pieces to puzzle in 1993 death. July 27. Accessed August 5, 2025. https://www.redrocknews.com/2020/07/27/sedona-police-department-adds-more-pieces-to-puzzle-of-1993-death/.—. 2020. Sedona Police Department returns to 1993 case. July 16. Accessed August 5, 2025. https://www.redrocknews.com/2020/07/16/sedona-police-department-returns-to-1993-case/.Irish, Robert. 1993. Sedona Police Department Supplementary Report, case #93-4944. Supplementary Report, Sewdoa, Arizona: Sedona Police Department.Keen, Dr. Philip. 1993. Report of Autopsy, Stephanie Wasilishin. Autopsy, Phoenix, Arizona: Maricopa County Office of the Medical Examiner.Spokes, Walter. 1993. Russell Peters interview, 10-21-93. Interview transcript, Sedona, Arizona: Sedona Police Department.Spokes, Walter. 1993. Supplementary Report, case # 93-4944. Incident report, Sedona, Arizona: Sedona Police Department. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In this Complex Care Journal Club podcast episode, Ms. Kathryn Knight and Dr. Brian K. Jordan discuss a national survey of families of children with medical complexity on access to home health nursing. They describe the impact of the nursing shortage on families, development of a nonprofit resource that facilitates connections between families and home nursing, and outline next steps from this work. Learn more about Hello Nurze: www.hellonurze.com Find additional details about the F.A.C.E.S. Project: www.hellonurze.com/p/faces-project SPEAKERS Kathryn Knight, BBA Co-Founder & Executive Director, Hello Nurze Brian K. Jordan, MD, PhD Associate Professor Oregon Health & Science University HOST Emily J. Goodwin, MD Clinical Associate Professor of Pediatrics University of Missouri Kansas City School of Medicine Pediatrician, General Academic Pediatrics Beacon Program Children's Mercy Kansas City DATE Initial publication date: September 8, 2025. JOURNAL CLUB ARTICLE Knight K, Knight G, Jordan BK. The Impact of the Lack of Access to Home Health Nursing on Families of Children with Medical Complexity in the United States. Home Healthc Now. 2025 Jul-Aug 01;43(4):213-220. doi: 10.1097/NHH.0000000000001356. Epub 2025 Jul 7. PMID: 40619624. OTHER ARTICLES REFERENCED Baker CD, Martin S, Thrasher J, Moore HM, Baker J, Abman SH, Gien J. A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children. Pediatrics. 2016 Apr;137(4):e20150637. doi: 10.1542/peds.2015-0637. Epub 2016 Mar 10. PMID: 26966133; PMCID: PMC4811306. Hello Nurze. Connecting families and in-home nurses. Accessed August 27, 2025. https://www.hellonurze.com Moore PE, Boyer D, O'Connor MG, Baker CD, Rettig JS, Sterni L, Halbower A, Wilson KC, Thomson CC. Pediatric Chronic Home Invasive Ventilation. Ann Am Thorac Soc. 2016 Jul;13(7):1170-2. doi: 10.1513/AnnalsATS.201603-196CME. PMID: 27388405; PMCID: PMC5462000. TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/87x9cmw5xfnkkt74v5g5pv3/Jordan_and_Knight_Final_Transcript__9-5-25 Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Knight K, Jordan BK, Goodwin EJ. From Crisis to Connection: Matching Families with Home Nursing Support in Complex Care. 09/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/from-crisis-to-connection-matching-families-with-home-nursing-support-in-complex-care.
In a conversation with CancerNetwork®, Geraldine O'Sullivan Coyne, MD, MRCPI, PhD, spoke about her new appointment as the principal investigator and director of Clinical Research at the Northwell Health unit of the Southern Texas Accelerated Research Therapeutics (START) Center for Cancer Research. Based on a strategic partnership formed between Northwell Health and START in May 2024, she will oversee early-phase clinical trial development at New York's first START research site at the R.J. Zuckerberg Cancer Center in New Hyde Park. Coyne began by sharing her excitement to put all her efforts into making the unit a “good opportunity” to consider patients who reside in community settings for enrollment in new clinical trials. Although large academic centers may offer possibilities for enrolling in trials, Coyne highlighted how many patients may need to travel or leave their social networks behind as they undergo treatment, thus illustrating a need for expanded options in the community setting. “Having the privilege to be able to bring trial opportunities into the community—into the heart of the community—is what we are aiming to do,” Coyne stated about her new role. “We do believe that this will [allow] patients to access novel and powerful therapies that are now increasingly part of a personalized treatment paradigm for patients with advanced malignancies.” Emphasizing the pursuit of early-phase clinical investigations, Coyne described how the new unit may leverage START's expertise to advance novel molecules across all stages of the drug development pipeline up to regulatory approval. She noted that being able to safely create and refine new therapeutic approaches in the community setting lies at the heart of a successful collaboration between Northwell Health and START. “A lot of the excitement surrounding the START unit and Northwell Health collaboration with them is exploring these novel molecules that will hopefully continue to build on the pursuit in oncology drug development, which has been finding better and more targeted therapies for patients in their treatment journey,” Coyne said. Reference Olt B. Northwell names Geraldine O'Sullivan Coyne, MD, PhD, to lead clinical trials at new START center. News release. Northwell Health. July 22, 2025. Accessed August 12, 2025. https://tinyurl.com/bdcua8ck
When you think Salem, you probably envision Essex Street or the Common, perhaps the Willows or Derby Street. But what about islands in Salem Sound? Wait - Salem has islands?! You bet! And quite a few at that. Join Jeffrey and Sarah, your favorite Salem tour guides, as they explore what lies beyond Salem's shores. We'll cover just two of Salem's many Islands in our first installment: Baker's Island and Misery Island. Let's talk private beaches, lighthouses, sunken ships, wildlife preserves, fires, hotels - there's so much to explore! Bakers Island Light Station. n.d. See the Light! Visit Bakers Island Light Station. https://www.bakersislandlight.org/ Salem Tales: Baker's Island. n.d. SalemWeb. https://salemweb.com/about-salem/salem-tales/bakers-island/ Bakers Island [Photograph Collection]. n.d. Flickr, “Salem State Archives.” https://www.flickr.com/photos/salemstatearchives/albums/72157670746281168/ Rosenberg, Steven A. 2012. "Baker's Island Residents Wary of an Influx of Visitors." Boston.com, August 9, 2012. https://www.boston.com/news/local-news/2012/08/09/bakers-island-residents-wary-of-an-influx-of-visitors/ Baker's Island. n.d. Salem Links and Lore. https://salempl.org/wiki/index.php?title=Baker%27s_Island Baker's Island Salem, Massachusetts [Online Forum Post]. n.d. Reddit, r/massachusetts. https://www.reddit.com/r/massachusetts/comments/r4kf8x/bakers_island_salem_massachusetts/ The Bakers Bulletin – Lighthouse Living on the New England Coast. n.d. The Bakers Bulletin (blog). https://bakersbulletin.wordpress.com/ "A4U0zrTHxfY" [YouTube video]. n.d. https://www.youtube.com/watch?v=A4U0zrTHxfY Farmhouse Fixers, season 3, episode 4. n.d. (TV episode). The Trustees of Reservations. Misery Islands History. Accessed August 1, 2025. The Trustees of Reservations.Wikipedia+1The Trustees of Reservations+4The Trustees of Reservations+4Wikipedia+4 “Misery Islands.” In Misery Island – Salem Links and Lore. Last modified April 20, 2017. Salem Links and Lore. Salem Public Library (Massachusetts) “Misery Islands.” Wikipedia. Last modified [date retrieved]. Accessed August 1, 2025. WCVB+5Wikipedia+5The Trustees of Reservations+5 “Misery Islands.” Coastal Byway. Accessed August 1, 2025. Essex Coastal Scenic Byway “The Lost Bungalows of Great Misery Island.” Street of Salem, June 27, 2017. New England Historical Society. “Steamboat City of Rockland, The Cursed Ship of the Tourist Trade.” New England Historical Society, originally published approximately 9 years ago; updated 2024. Accessed August 1, 2025. Interested in Salem The Podcast Merch!? CLICK HERE! Interested in supporting the Podcast? Looking for more Salem content? CLICK HERE! www.salemthepodcast.com NEW INSTAGRAM - @salemthepod Email - hello@salemthepodcast.com Book a tour with Sarah at Bewitched Historical Tours www.bewitchedtours.com Book a tour with Jeffrey at Salem Uncovered Tours www.salemuncoveredtours.com Intro/Outro Music from Uppbeat: https://uppbeat.io/t/all-good-folks/unfamiliar-faces License code: NGSBY7LA1HTVAUJE
When you think Salem, you probably envision Essex Street or the Common, perhaps the Willows or Derby Street. But what about islands in Salem Sound? Wait - Salem has islands?! You bet! And quite a few at that. Join Jeffrey and Sarah, your favorite Salem tour guides, as they explore what lies beyond Salem's shores. We'll cover just two of Salem's many Islands in our first installment: Baker's Island and Misery Island. Let's talk private beaches, lighthouses, sunken ships, wildlife preserves, fires, hotels - there's so much to explore! Bakers Island Light Station. n.d. See the Light! Visit Bakers Island Light Station. https://www.bakersislandlight.org/ Salem Tales: Baker's Island. n.d. SalemWeb. https://salemweb.com/about-salem/salem-tales/bakers-island/ Bakers Island [Photograph Collection]. n.d. Flickr, “Salem State Archives.” https://www.flickr.com/photos/salemstatearchives/albums/72157670746281168/ Rosenberg, Steven A. 2012. "Baker's Island Residents Wary of an Influx of Visitors." Boston.com, August 9, 2012. https://www.boston.com/news/local-news/2012/08/09/bakers-island-residents-wary-of-an-influx-of-visitors/ Baker's Island. n.d. Salem Links and Lore. https://salempl.org/wiki/index.php?title=Baker%27s_Island Baker's Island Salem, Massachusetts [Online Forum Post]. n.d. Reddit, r/massachusetts. https://www.reddit.com/r/massachusetts/comments/r4kf8x/bakers_island_salem_massachusetts/ The Bakers Bulletin – Lighthouse Living on the New England Coast. n.d. The Bakers Bulletin (blog). https://bakersbulletin.wordpress.com/ "A4U0zrTHxfY" [YouTube video]. n.d. https://www.youtube.com/watch?v=A4U0zrTHxfY Farmhouse Fixers, season 3, episode 4. n.d. (TV episode). The Trustees of Reservations. Misery Islands History. Accessed August 1, 2025. The Trustees of Reservations.Wikipedia+1The Trustees of Reservations+4The Trustees of Reservations+4Wikipedia+4 “Misery Islands.” In Misery Island – Salem Links and Lore. Last modified April 20, 2017. Salem Links and Lore. Salem Public Library (Massachusetts) “Misery Islands.” Wikipedia. Last modified [date retrieved]. Accessed August 1, 2025. WCVB+5Wikipedia+5The Trustees of Reservations+5 “Misery Islands.” Coastal Byway. Accessed August 1, 2025. Essex Coastal Scenic Byway “The Lost Bungalows of Great Misery Island.” Street of Salem, June 27, 2017. New England Historical Society. “Steamboat City of Rockland, The Cursed Ship of the Tourist Trade.” New England Historical Society, originally published approximately 9 years ago; updated 2024. Accessed August 1, 2025. Interested in Salem The Podcast Merch!? CLICK HERE! Interested in supporting the Podcast? Looking for more Salem content? CLICK HERE! www.salemthepodcast.com NEW INSTAGRAM - @salemthepod Email - hello@salemthepodcast.com Book a tour with Sarah at Bewitched Historical Tours www.bewitchedtours.com Book a tour with Jeffrey at Salem Uncovered Tours www.salemuncoveredtours.com Intro/Outro Music from Uppbeat: https://uppbeat.io/t/all-good-folks/unfamiliar-faces License code: NGSBY7LA1HTVAUJE
About this Episode Episode 48 of “The 2 View” – Burn Tx, Marijuana & CV Risk, Ocular Syphilis, and HSV 1 & 2 Segment 1 – Thermal Burn Treatment Levin NJ, Erben Y, Li Y, et al. Edited by Muacevic A, Adler JR. A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera. Cureus. 2022;14(10):e30815. Accessed August 11, 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC9621733/ Aziz Z, Abdul Rasool Hassan B. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns. 2017;43(1):50-57. Accessed August 11, 2025. https://pubmed.ncbi.nlm.nih.gov/27576926/ Segment 2A – Marijuana and Cardiovascular Risk Mohammadi L, Navabzadeh M, Jimenez-Tellez N, et al. Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use. JAMA Cardiol. Published online May 28, 2025. doi:10.1001/jamacardio.2025.1399. Accessed August 11, 2025. https://jamanetwork.com/journals/jamacardiology/fullarticle/2834540 Storck W, Elbaz M, Vindis C, et al. Eifling KP, Gaudio FG, Dumke C, et al. Cardiovascular risk associated with the use of cannabis and cannabinoids: a systematic review and meta-analysis. Heart. Published online June 17, 2025. doi:10.1136/heartjnl-2024-325429. Accessed August 11, 2025. https://pubmed.ncbi.nlm.nih.gov/40527600/ Page II RL, Allen LA, Kloner RA, et al. Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association. Circulation. 2020;142(10);e131-152. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000883 Segment 2B – Ocular Syphilis Zhou LR, Kirupaharan N, Birkenstock MK. Incidence and Prevalence of Syphilitic Uveitis and Associated Ocular Complications in the TriNetX Database. Am J Ophthalmol. 2025;277:387-394. https://www.sciencedirect.com/science/article/pii/S0002939425002843 Segment 3 - HSV 1 & 2 Langenberg AGM, Corey L, Ashley RL, et al. A Prospective Study of New Infections with Herpes Simplex Virus Type 1 and Type 2. N Engl J Med. 1999;341:1432-1438. https://www.nejm.org/doi/full/10.1056/nejm199911043411904 Lebrun-Vignes B, Bouzamondo A, Dupuy A, et al. A meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks. J Am Acad Dermatol. 2007;57(20):238-246. Recurring Sources Center for Medical Education. http://ccme.org The Proceduralist. http://www.theproceduralist.org The Procedural Pause. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. http://www.thesgem.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to.
In this Complex Care Journal Club podcast episode, Dr. Robbie Dembo and Ms. Kate Honsberger discuss a mixed methods study of oral health experiences and disparities among children with special health care needs. They describe oral health problems faced by children with medical complexity, barriers to high-quality dental care reported by family caregivers, and strategies for disseminating findings from their study. SPEAKERS Robbie Dembo, PhD Senior Research Scientist Principal Investigator National Opinion Research Center (NORC) University of Chicago Kate Honsberger, BA Director, Health Care Programs National Opinion Research Center (NORC) University of Chicago HOST Kristina Malik, MD Assistant Professor of Pediatrics, University of Colorado School of Medicine Medical Director, KidStreet Pediatrician, Special Care Clinic, Children's Hospital Colorado DATE Initial publication date: August 11, 2025. JOURNAL CLUB ARTICLE NORC at the University of Chicago. Oral Health Among Children with Special Health Care Needs. Accessed August 4, 2025. https://www.norc.org/research/projects/oral-health-children-special-health-care-needs.html OTHER ARTICLES REFERENCED Child and Adolescent Health Measurement Initiative. Shared care planning for children with special health care needs. Accessed August 4, 2025. https://www.cahmi.org/our-work-in-action/engagement-in-action/cshcn Cohen E, Kuo DZ, Agrawal R, Berry JG, Bhagat SK, Simon TD, Srivastava R. Children with medical complexity: an emerging population for clinical and research initiatives. Pediatrics. 2011 Mar;127(3):529-38. doi: 10.1542/peds.2010-0910. Epub 2011 Feb 21. PMID: 21339266; PMCID: PMC3387912. Yu JA, McKernan G, Hagerman T, Schenker Y, Houtrow A. Identifying children with medical complexity from the National Survey of Children's Health combined 2016–17 data set. Hospital Pediatrics. 2021;11(2):192- 197. doi:10.1542/hpeds.2020-0180 TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/9767nfr2rj79c2hft2cc3g8/Dembo_and_Hornsberget_final_8-7-25 Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Dembo R, Honsberger K, Malik K. Brushing Up on High-Quality Oral Health Care for Children with Medical Complexity. 08/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/brushing-up-on-high-quality.
On November 1, 1955, United Airlines flight 629 from Denver, Colorado to Seattle, Washington took off from Denver's Stapleton Airfield at 6:52 pm, carrying thirty-nine passengers and five crew members. Roughly ten minutes later, the aircraft exploded in the air, killing all forty-four people onboard and scattering fiery debris across several miles of Colorado's landscape.By the early 1950s, air travel had become a popular means of travel for more and more Americans and, while air disasters weren't unheard of, they nonetheless called into question the safety of traveling on a passenger flight. This time, however, investigators quickly determined that the explosion of flight 629 hadn't been an accident; someone had intentionally sabotaged the flight with a suitcase bomb.The explosion of United Airlines flight 629 marked the first time a passenger plane had been bombed in the United States, something few if any authorities ever thought would happen. In the event of an act of terror, an individual or group typically comes forward quickly to claim credit; however, in the case of flight 629, no one came forward and investigators were left to wonder, what possible reason could someone have for killing forty-four people with no obvious connection between them?Thank you to the Incredible Dave White of Bring Me the Axe Podcast for research and Writing support!ReferencesAnastasio, Jeff. 2024. A worst act of terror. August 2. Accessed August 6, 2024. https://www.denver7.com/news/local-news/a-worst-act-of-terror-the-mission-to-build-a-memorial-to-remember-the-bombing-of-flight-629-in-colorado.Associated Press. 1955. "Arraignment for Graham postponed." Daily Sentinel, November 17: 1.—. 1955. "Charge of murder planned in Denver on mother's death." Fort Collins Coloradoan, November 15: 1.—. 1955. "FBI begins investgation of Longmont air crash." Fort Collins Coloradoan, November 8: 1.—. 1955. "Graham denies plane bombing." Fort Collins Coloradoan, November 18: 1.—. 1955. "Graham linked to dynamite." Fort Collins Coloradoan, November 21: 1.—. 1955. "Judge orders hospital check." Fort Collins Coloradoan, December 9: 1.—. 1955. "Paper says bomb evidence found in UAL plane crash." Fort Collins Coloradoan, November 7: 1.—. 1955. "Probe is started by bomb expert." Fort Collins Coloradoan, November 3: 1.—. 1955. "Victim's son bought insurance policy before flight, FBI says." Fort Collins Coloradoan, November 14: 1.2013. A Crime to Remember. Directed by Christine Connor. Performed by Christine Connor.Field, Andrew. 2005. Mainliner Denver: The Bombing of Flight 629. Denver, CO: Bower House Publishing.Garner, Joe. 2005. "Terror in the Colorado sky John Graham's legacy: The mass murder of 44 people in Nov. '55." Rocky Mountain News, October 14.Gauss, Gordon. 1955. "44 die in crash near Longmont." Daily Sentinel, November 2: 1.John Gilbert Graham v. People of the State of Colorado. 1956. 18058 (Supreme Court of Colorado, October 22).Pitman, Frank. 1956. "Graham reportedly resigned to death, overheard telling lawyer 'don't want to appeal'." Daily Sentinel, May 6: 1.United Press. 1955. "44 on plane die in crash in west." New York Times, November 2: 1.Stay in the know - wondery.fm/morbid-wondery.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Did you know that congenital cytomegalovirus (cCMV) is the most common congenital viral infection in newborns and a leading cause of non-genetic hearing loss? Despite its prevalence, awareness and screening for cCMV remain inconsistent across healthcare systems. In this episode, we dive into the critical importance of cCMV screening, early diagnosis, and intervention. Join our expert guests Dr. Ingrid Camelo and Dr. John Noel as they discuss: The impact of cCMV on neonatal and long-term health outcomes Best practices for screening and diagnostic methods The role of early intervention, including antiviral therapy How advocacy efforts are shaping the future of universal screening policies Tune in to stay informed on how pediatricians and healthcare providers can play a vital role in improving outcomes for infants affected by cCMV. Special thanks to Dr. James Grubbs for peer reviewing this episode. CME Credit (requires free sign up): Link Coming Soon! References: American Academy of Pediatrics. A targeted approach for congenital cytomegalovirus. Available at: https://publications.aap.org/pediatrics/article/139/2/e20162128/60211/A-Targeted-Approach-for-Congenital-Cytomegalovirus. Accessed August 13, 2024. Chiopris G, Veronese P, Cusenza F, Procaccianti M, Perrone S, Daccò V, Colombo C, Esposito S. Congenital cytomegalovirus infection: update on diagnosis and treatment. Microorganisms. 2020 Oct 1;8(10):1516. doi: 10.3390/microorganisms8101516. PMID: 33019752; PMCID: PMC7599523. Gantt S. Newborn cytomegalovirus screening: is this the new standard? Curr Opin Otolaryngol Head Neck Surg. 2023 Dec 1;31(6):382-387. doi: 10.1097/MOO.0000000000000925. Epub 2023 Oct 11. PMID: 37820202. Minnesota Department of Health. Minnesota implements universal newborn screening for cytomegalovirus. Available at: https://www.health.state.mn.us/news/pressrel/2023/ccmv020823.html. Accessed August 13, 2024. National CMV Foundation. Advocacy: universal newborn CMV screening. Available at: https://www.nationalcmv.org/about-us/advocacy#:~:text=Minnesota%20was%20the%20first%20state%20to%20enact%20universal%20newborn%20CMV%20screening. Accessed August 13, 2024. New York State Department of Health. Newborn screening for cytomegalovirus. Available at: https://www.health.ny.gov/press/releases/2023/2023-09-29_newborn_screening.htm#:~:text=ALBANY%2C%20N.Y.,all%20babies%20for%20the%20virus. Accessed August 13, 2024. UpToDate. Congenital cytomegalovirus (CMV) infection: clinical features and diagnosis. Available at: https://www.uptodate.com/contents/congenital-cytomegalovirus-ccmv-infection-clinical-features-and-diagnosis?search=cmv%20screening&source=search_result&selectedTitle=1%7E28&usage_type=default&display_rank=1#H92269684. Accessed August 13, 2024. UpToDate. Congenital cytomegalovirus (CMV) infection: management and outcome. Available at: https://www.uptodate.com/contents/congenital-cytomegalovirus-ccmv-infection-management-and-outcome?search=congenital%20cmv&source=search_result&selectedTitle=2%7E66&usage_type=default&display_rank=2. Accessed August 13, 2024. UpToDate. Ganciclovir and valganciclovir: an overview. Available at: https://www.uptodate.com/contents/ganciclovir-and-valganciclovir-an-overview?search=ganciclovir&source=search_result&selectedTitle=2%7E80&usage_type=default&display_rank=1#H6. Accessed August 13, 2024. University of Texas Medical Branch. Neonatology manual: infectious diseases. Available at: https://www.utmb.edu/pedi_ed/NeonatologyManual/InfectiousDiseases/InfectiousDiseases3.html#:~:text=may%20be%20required.-,Cytomegalovirus,Clinical%20findings. Accessed August 13, 2024. National Center for Biotechnology Information. Cytomegalovirus (CMV) infection. Available at: https://www.ncbi.nlm.nih.gov/books/NBK541003/. Accessed August 13, 2024.
Joining us for this episode of Feedstuffs in Focus is Dr. David Baumert, Senior Technical Services Veterinarian at Zoetis Pork, to discuss the reasons why producers sometimes choose not to treat pigs — usually heavier weight finishers — in need of swine respiratory disease (SRD) therapy and the implications of non-use from a performance, labor and economic standpoint. This episode of Feedstuffs in Focus has been brought to you by Zoetis Pork.IMPORTANT SAFETY INFORMATION: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to EXCENEL RTU EZ. Do not use in swine found to be hypersensitive. Withdraw 6 days prior to slaughter when injection site volumes are greater than 5 mL up to 15 mL per injection site and 4 days prior to slaughter when injection site volumes are less than or equal to 5 mL per injection site. See full Prescribing Information at Excenelpork.com/PI.ReferencesPantoja L, Kuhn M, Farrand E, et al. Impact of a Husbandry Education Program on nursery pig mortality, productivity, and treatment cost. Journal of Swine Health and Production [serial online]. 2013;21 (4):188-194. Available from: CAB Abstracts, Ipswich, MA. Accessed May 1, 2018. Pineiro C, Morales J, Doncecchi P, et al. Individual Pig Care program improves productive performance and animal health in nursery-growing pigs. Journal of Swine Health and Production [serial online]. 2014;22 (6):296-299. Available from: CAB Abstracts, Ipswich, MA. Accessed August 1, 2018.Bowersock, T. L., Meeuwse, D. M., Kausche, F. M., Lucas, M. J., Bryson, W. L. and Dame, K.J. Efficacy of ceftiofur crystalline free acid and ceftiofur hydrochloride administered intramuscularly in swine inoculated with Actinobacillus pleuropneumoniae. Pharmacia Animal Health. 2001. Data on file, Study Document No. ZRD-PSC-004402, Zoetis Inc.All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2024 Zoetis Services LLC. All rights reserved. EXC-00084
This episode is a mini episode about a famous artist who had to fight from having everything taken away from her. You might have even seen the movie about her life. SOURCES Flynn, William. “Where Did He Get Those Eyes.” The San Francisco Examiner (San Francisco, California), October 14, 1970. www.newspapers.com. Kobayashi, Ken. “Jury Awards $4 Million In Art Trial.” The Honolulu Advertiser (Honolulu, Hawaii), June 4, 1986. www.newspapers.com. Margaret Keane - paintings, Movie & Big Eyes. Accessed August 27, 2024. https://www.biography.com/artist/margaret-keane. “Margaret Keane.” Wikipedia, August 25, 2024. https://en.wikipedia.org/wiki/Margaret_Keane. “Margaret Keane: Big Eyes Artist, Whose Husband Claimed Credit, Dies at 94.” BBC News, June 29, 2022. https://www.bbc.com/news/entertainment-arts-61980385. “Relative of Discredited ‘big Eyes' Artist Makes a Keane Defense.” Los Angeles Times, January 2, 2015. https://www.latimes.com/entertainment/arts/la-et-cm-keane-nephew-20150102-story.html. Ronck, Ronn. “Margaret Keane Issues New Challenge for Paint-Out.” Honolulu Star-Advertiser (Honolulu, Hawaii), July 1, 1984. www.newspapers.com. SOUND SOURCES Al Jolson. “I'll Say She Does.” www.pixabay.com/music. Lucille Hegamin and The Dixie Daisies. “Cold Winter Blues.” www.pixabay.com/music. Sophie Tucker. “Reuben Rag.” www.pixabay.com/music.
On March 12, 1912, the Girl Scouts of America had their very first meeting ever. Since then, millions of girls have participated in the organization. What else was making news on that exact same day in history? Find out with three fun additional history stories. SOURCES “10 Things You Probably Didn't Know about Girl Scouts.” GSCCC Blog, July 11, 2019. https://girlscoutsccc.com/2019/07/18/10-things-you-probably-didnt-know-about-girl-scouts/. “About Early Girl Scouting.” Juliette Gordon Low Birthplace. Accessed August 21, 2024. https://www.juliettegordonlowbirthplace.org/en/explore/history/about-early-girl scouting.html#:~:text=Whenever%20there%20was%20a%20question,the%20United%20States%20in%201913. “Advertisement: Olympic and Titanic (Page 21).” Chicago Tribune (Chicago, Illinois), March 12, 1912. www.newspapers.com. “Bring Boy Back to Reformatory.” Star-Gazette (Elmira, New York), March 14, 1912. www.newspapers.com. “The Cardiff Giant Fools The Nation, 145 Years Ago.” History.com. Accessed August 22, 2024. https://www.history.com/news/the-cardiff-giant-fools-the-nation-145-years-ago. “Cardiff Giant.” Wikipedia, August 19, 2024. https://en.wikipedia.org/wiki/Cardiff_Giant. www.newspapers.com. “Circuit Court.” Dubbo Dispatch (Dubbo, New South Wales, Australia), April 16, 1912. www.newspapers.com. “The Cumnock Poisoning Case: Some Additional Evidence.” The Leader (Orange, New South Wales, Australia), March 12, 1912. www.newspapers.com. “Cumnock Sensation: Death of Mrs. Johnson.” The Molong Express (Molong, New South Wales, Australia), March 16, 1912. www.newspapers.com. “Death of Mrs. Johnson.” The Molong Argus (Molong, New South Wales, Australia), October 13, 1911. www.newspapers.com. “First Own Sound Company of Girl Guides.” Owen Sound Sun (Owen Sound, Ontario, Canada), March 12, 1912. www.newspapers.com. “Juliette Gordon Low: Girl Scouts.” Girl Scouts of the USA. Accessed August 21, 2024. https://www.girlscouts.org/en/discover/about-us/history/juliette-gordon-low.html. “Sell CardiffcGiant Pay Storage Claim.” Star-Gazette (Elmira, New York), October 31,c1912. www.newspapers.com. “Sues for ‘Board' of Cardiff Giant.” Star-Gazette (Elmira, New York), March 14, 1912. www.newspapers.com. “‘Cardiff Giant' Again.” St. Joseph News-Press (St. Joseph, Missouri), March 12, 1912. www.newspapers.com. “'Twas Good Story But Wasn't True.” Star-Gazette (Elmira, New York), March 18, 1912. www.newspapers.com. SOUND SOURCES Al Jolson. “I'll Say She Does.” www.pixabay.com/music. Lucille Hegamin and The Dixie Daisies. “Cold Winter Blues.” www.pixabay.com/music. Sophie Tucker. “Reuben Rag.” www.pixabay.com/music.
Being queen is never easy, and no one knew that better than Queen Min. At only eight years old, she was left without a father, but funnily enough, her lack of ambitious male relatives made her the perfect candidate for queen to the irresponsible and impressionable King of Korea. Min bided her time under the thumb of her overbearing father-in-law until she was able to outsmart him and take over the court. Over her twenty-year reign, she managed to modernize Korea in everything from the military to education, all while dealing with the encroaching Japanese empire. Join me to learn about her story on today's episode. This podcast is sponsored by Common Era Jewelry. Use code: AYDEN for 15% off your entire purchase. Bibliography Administration, Cultural Heritage. “Birth Home of Empress Myeongseong - Heritage Search.” Cultural Heritage Administration. Accessed August 28, 2024. https://english.cha.go.kr/chaen/search/selectGeneralSearchDetail.do?mn=EN_02_02&sCcebKdcd=21&ccebAsno=00460000&sCcebCtcd=31&pageIndex=388®ion=&canAsset=&ccebPcd1=&searchWrd=&startNum=&endNum=&stCcebAsdt=&enCcebAsdt=&canceled=&ccebKdcd=&ccebCtcd=. Contributors to Wikimedia projects. “Empress Myeongseong.” Wikipedia, August 26, 2024. https://en.wikipedia.org/wiki/Empress_Myeongseong#Photographs_and_illustrations. ———. “Gojong of Korea.” Wikipedia, August 27, 2024. https://en.wikipedia.org/wiki/Gojong_of_Korea. ———. “History of Women in Korea.” Wikipedia, June 23, 2024. https://en.wikipedia.org/wiki/History_of_women_in_Korea. ———. “Internal Princess Consort Hanchang.” Wikipedia, March 25, 2024. https://en.wikipedia.org/wiki/Internal_Princess_Consort_Hanchang. ———. “Min Chi-Rok.” Wikipedia, June 4, 2024. https://en.wikipedia.org/wiki/Min_Chi-rok. ———. “Shamanism.” Wikipedia, August 25, 2024. https://en.wikipedia.org/wiki/Shamanism#Ecological_aspect. ———. “Sunjong of Korea.” Wikipedia, July 12, 2024. https://en.wikipedia.org/wiki/Sunjong_of_Korea. New World Encyclopedia. “Empress Myeongseong.” Accessed August 28, 2024. https://www.newworldencyclopedia.org/entry/Empress_Myeongseong. “FamilySearch.Org.” Accessed August 28, 2024. https://www.familysearch.org/en/surname?surname=min. MadMonarchist. “Consort Profile: Empress Myeongseong of Korea.” Accessed August 28, 2024. https://madmonarchist.blogspot.com/2011/10/consort-profile-empress-myeongseong-of.html. Szczepanski, Kallie. “Biography of Queen Min, Korean Empress.” ThoughtCo, July 23, 2012. https://www.thoughtco.com/queen-min-of-joseon-korea-195721. Team, Gale Review. “The Murder of Empress Myeongseong of Korea.” The Gale Review, August 16, 2022. https://review.gale.com/2022/08/16/the-murder-of-empress-myeongseong-of-korea/. “The Legacy of Joseon Korea (1392-1897).” Accessed August 28, 2024. https://www.roots.gov.sg/stories-landing/stories/the-legacy-of-joseon-korea/story.
When eighteen-year-old recent high school graduate Tiffany Valiante was struck and killed by a train in July 2015, the news came as a shock to friends and family, who couldn't fathom why the teenager had been out walking the tracks that night. Their shock and confusion quickly turned to outrage and disbelief when, less than twenty-four hours later, Tiffany's death was ruled a suicide by the New Jersey Transit Police, who were tasked with investigating the incident. As far as everyone knew, Tiffany was a happy, outgoing girl with a bright future and a sports scholarship to Mercy College in the fall—they couldn't think of a single reason why she would have wanted to end her life. Despite the official conclusions about her death, the Valiante family have never believed Tiffany intentionally stepped in front of the train that night, and in the months and years that have passed since her death, many other people have come to a similar conclusion. In fact, they're confident the evidence and numerous unanswered questions suggest Tiffany had not gone into the woods voluntarily and that her death is at best suspicious, and at worst a murder. Thank you to the incredible Dave White of Bring Me The Axe Podcast for research and writing support! ReferencesConklin, Eric. 2023. "Family of Tiffany Valiante marks 8 years since teen's death with 2nd docuseries in the works." Press of Atlantic City, July 24.Daily Beast. 2022. "Was high school grad being chased before grisly train death?" Daily Beast, July 16.D'Amato Law. 2017. "“It's just not the Tiffany I knew,” said Allison Walker, head women's volleyball coach at Stockton University who coached Valiante in the East Coast Crush Volleyball Club, a junior travel volleyball team. “The time of night really didn't sit right with me." D'Amato Law. July 17. Accessed August 20, 2024. https://damatolawfirm.com/in-the-news/who-killed-tiffany-valiante-questions-persist-as-family-marks-the-third-anniversary-of-her-mysterious-death/.—. 2022. Mishandling Key Evidence In 2015 Tiffany Valiante Suspicious Death Case Impeded Independent Forensic DNA Analysis, Reports Renowned Lab. March 29. Accessed August 20, 2024. https://damatolawfirm.com/in-the-news/mishandling-key-evidence-in-2015-tiffany-valiante-suspicious-death-case/.DeAngelis, Martin. 2016. "Death of teen not suicide, suit says." Press of Atlantic City, July 20: 3.DiFilippo, Dana, and Joe Hernandez. 2017. Family of N.J. teen killed by train disputes suicide ruling, sues to prove kidnap-murder plot. July 19. Accessed August 19, 2024. https://whyy.org/articles/family-of-nj-teen-killed-by-train-disputes-suicide-ruling-sues-to-prove-kidnap-murder-plot/.Houseman, H. Louise. 2017. Investigative report submitted by H. Louise Hoiusman, Senior Medical Investigator. Investigative Report, Egg Harbor, NJ: D'Amato Law.Huba, Nicholas. 2015. "Suicides shock, sadden teens." Press of Atlantic City, July 19: 1.Jason, Dr. Donald. 2018. Re: Death of Tiffany Valiante. Forensic evaluation, Egg Harbor, NJ: D'Amato Law.Low, Claire. 2018. "A walk thgrough hell." Press of Atlantic City, December 16: 1.Morgan, Kate. 2022. Tiffany Valiante's last night. November. Accessed August 15, 2024. https://sjmagazine.net/featured/tiffany-valiantes-last-night.Stephen F. Valiante and Diane F. Valiante v. Does et al. 2017. ATL-L-1411-17 (Superior Court of New Jersey, Law Division, July 18).Sterling, Stephen, and S.P. Sullivan. 2017. Death and dysfunction: HGow N.J. fails the dead, betrays the living and is a national disgrace. December 14. Accessed August 19, 2024. https://death.nj.com/.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
1014. This week, we debunk misconceptions about gendered language, tracing the etymology of words like "cockamamie" and "gynecology." We also look at the flexibility of English grammar, examining how common words like "that" and "up" can function as different parts of speech in various contexts.The "gendered words" segment was written by Samantha Enslen, who runs Dragonfly Editorial. You can find her at dragonflyeditorial.com.The "grammar leaks" segment was written by Edwin Battistella, who taught linguistics and writing at Southern Oregon University in Ashland, where he served as a dean and as interim provost. His books include Bad Language: Are Some Words Better than Others?, Sorry About That: The Language of Public Apology, and Dangerous Crooked Scoundrels: Insulting the President, from Washington to Trump. It originally appeared on the OUP blog and is included here with permission.
Mary Todd Lincoln does not have the best reputation amongst first ladies. She was remembered in her time as a mentally unstable overspender who had questionable ties to the Confederacy. However, in this episode, I want pepole to learn about the bright and independent young woman who tried to make the best of every situation she was in and suffered more tragedy than anyone could understand. Join me on this episode as we talk about the sad but extraordinary life of Mary Todd Lincoln. This podcast is sponsored by Common Era Jewelry. Use code: AYDEN for 15% off your entire order. Boomer, Lee. “Life Story: Mary Todd Lincoln (1818-1882).” Women & the American Story, November 11, 2020. https://wams.nyhistory.org/a-nation-divided/civil-war/mary-todd-lincoln/. Caroli, Betty Boyd. “Mary Todd Lincoln.” Encyclopedia Britannica, July 20, 1998. https://www.britannica.com/biography/Mary-Todd-Lincoln. Contributors to Wikimedia projects. “Abraham Lincoln.” Wikipedia, August 8, 2024. https://en.wikipedia.org/wiki/Abraham_Lincoln#Assassination. ———. “Mary Todd Lincoln.” Wikipedia, July 26, 2024. https://en.wikipedia.org/wiki/Mary_Todd_Lincoln. ———. “Robert Smith Todd.” Wikipedia, June 26, 2024. https://en.wikipedia.org/wiki/Robert_Smith_Todd#Personal_life. Family, Death, Facts | HISTORY Mary Todd Lincoln: “Mary Todd Lincoln: Family, Death, Facts.” HISTORY, December 16, 2009. https://www.history.com/topics/first-ladies/mary-todd-lincoln. The White House. “Mary Todd Lincoln,” January 12, 2021. https://www.whitehouse.gov/about-the-white-house/first-families/mary-todd-lincoln/. Mary Todd Lincoln House. “Mary Todd Lincoln — Mary Todd Lincoln House.” Accessed August 9, 2024. https://www.mtlhouse.org/biography. “Mary Todd Lincoln Timeline and Highlights.” Accessed August 9, 2024. https://www.abrahamlincolnonline.org/lincoln/education/marytimeline.htm. Turner, Justin G. and Turner, Linda Levitt (1987) Mary Todd Lincoln: Her Life and Letters, Fromm International Pub. Corp. Emerson, Jason (2006). "The Madness of Mary Lincoln". American Heritage Magazine. Catherine Clinton, Mrs. Lincoln: A Life (New York: Harper Perennial, 2010)
Episode 176: Self-sampling for HPV screeningFuture Dr. Markarian explains the importance of HPV screening for the prevention of cervical cancer. Dr. Arreaza adds some insight about cervical cancer.Written by Chantal Markarian, MSIV, American University of the Caribbean. Editing and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Insights into Cervical Cancer.Chantal: Cervical cancer stands as the most prevalent form of cancer in women globally costing the lives of approximately 350,000 women annually. About 4,000 women die of cervical cancer a year in the US. Cervical cancer is initially asymptomatic, allowing it to advance to a more severe stage if not detected early. The positive news is that cervical cancer is highly preventable through screening for precancerous lesions or the presence of HPV —the primary culprit behind most cases.The role of HPV: Human Papilloma Virus, according to the World Health Organization, caused an estimated 620,000 cancer cases in women and 70,000 cancer cases in men.Cervical cancer is more prevalent in certain regions. In regions with established screening initiatives, the incidence rate and mortality rate of cancer are lower than in resource-limited areas. This highlights that resource-constrained countries continue to bear a burden of this disease. In nations like the United States, access to the HPV vaccine along with routine screenings, like Pap smears and HPV tests has significantly decreased the prevalence of cervical cancer.Screening recommendations from the US Preventive Services Task Force (USPSTF) and the American Cancer Society (ACS).The U.S Preventive Services Task Force advises that women aged 21 to 29 undergo a Pap test every three years while those aged 30 to 65 should opt for co-testing (Pap and HPV tests) every five years. These examinations are usually conducted in outpatient facilities, where a medical professional collects a sample of cervical cells that are later examined under a microscope.A normal result states that the sample was adequate for evaluation, in other words, that endocervical/transformation zone components are present, and that the patient is “Negative for intraepithelial lesion or malignancy.” ACS recommends cervical cancer screening begin at age 25 for women and people with a cervix. Those aged 25 to 65 should have a primary HPV test every 5 years. (A primary HPV test means the HPV test is done without cytology; follow-up screening can be done with a Papanicolaou (Pap) test if needed.) If primary HPV testing is not available, screening may be done with either a co-test every 5 years, which combines an HPV test with a Papanicolaou (Pap) test, or a Pap test alone every 3 years. How is Cervical Cancer Classified?Two systems categorize lesions: the Cervical Intraepithelial Neoplasia (CIN) scale and the Bethesda system.The CIN scale categorizes lesions based on the degree of involvement of the cervical lining ranging from mild (CIN I) to moderate (CIN II) to severe dysplasia (CIN III).The Bethesda system emphasizes cytological findings organizing results into categories such as atypical squamous cells, low-grade lesions (LSIL), and high-grade lesions (HSIL).ASCUS (Atypical Squamous Cells of Undetermined Significance) is the most common abnormality seen in pap smears. It may or may not indicate a problem, you have to make a decision based on the patient. Cervical cancer is largely linked to high-risk HPV (hrHPV), mostly HPV 16 and 18, and scientists are investigating tests that identify hrHPV DNA or RNA. These tests may provide a more accurate evaluation of cancer risk compared to traditional cytology. Examples include DNA amplification tests like Cobas test and the Xpert HPV test.Obstacles to Screening.Despite the efficacy of cervical cancer screening, many women face many obstacles to testing. In regions with limited resources, fear, embarrassment, lack of awareness, and restricted healthcare access pose challenges to screening.In Nigeria, a study revealed that women often avoid Pap smears due to a lack of awareness. Similarly, healthcare providers in Ecuador highlighted issues like the absence of screening programs and inadequate health promotion efforts. Women in Peru face obstacles such as long waiting times preferences for female healthcare providers and limited access to health facilities. In 2022, 31% of minority women in the US did not undergo Pap smears in the past three years; many of these women were uninsured, unemployed, or low-income. These challenges contribute to higher rates of cervical cancer among women who do not follow recommended screening guidelines.We must mention the cultural obstacle as well. Some cultures do not allow any kind of pelvic exams before marriage. They put a major emphasis on being a “virgin,” and placing a speculum in the vagina may be considered culturally unacceptable. In those cases, the doctor has to use their best persuasion skills to accomplish the goals of care. For example, they may suggest having the mother in the room during the pap smear, using the smallest speculum possible, or other techniques.Self-sampling.In 2020, the World Health Organization (WHO) introduced a global initiative to combat cervical cancer worldwide. The initiative aims to:Vaccinate 90% of girls by age 15.Screen 70% of women by age 35.Treat 90% of women with lesions and invasive cancer by 2030.To achieve these goals, self-sampling for HPV testing has been introduced as a viable option for cervical cancer screening. Self-sampling for HPV testing is seen as an alternative for cervical cancer screening that addresses barriers associated with traditional methods. This approach enables women to take samples themselves using swabs or brushes removing the necessity for a pelvic examination. The option to mail in samples and receive results within two weeks enhances the convenience, privacy, and accessibility of the process giving individuals control over their health.While self-sampling for hrHPV detection is not currently standard practice in the United States, it has been successfully implemented in countries across Europe, Africa, and South America. Pilot studies are ongoing in nations like Canada and New Zealand to assess its effectiveness offering promise for its impact.In May 2024, the Food and Drug Administration (FDA) approved primary HPV self-collection for cervical cancer screening in a health-care setting. That means, the patient still has to go to a clinic to self-collect her sample. How Effective is HPV Self-Sampling?Research supports the accuracy of HPV self-sampling. A study conducted by Polman et al., which involved a randomized controlled trial, demonstrated that HPV tests on self-collected samples were just as precise as those done on samples collected by clinicians in detecting high-grade lesions (CIN II and CIN III). Similarly, a meta-analysis conducted by Arbyn et al. showed no difference in sensitivity or specificity between self-sampled and clinician-sampled tests for detecting CIN grade II or higher.These results indicate that self-sampling could be an adequate screening method for cervical cancer. This reassurance may motivate women to partake in screenings knowing they have a convenient and effective option. Ok, let's say a patient has collected her sample or the sample was collected by a clinician, what is next?Management of Cervical Cancer Screening Results.The process of managing cervical cancer screening results involves evaluating a patient's immediate and five-year risk of developing cervical abnormalities (CIN 3+) following guidelines from the American Society for Colposcopy and Cervical Pathology (ASCCP).The ASCCP app is the best investment you can make in primary care. It is only $9.99, but it can save you a lot of time in clinic. Estimating risk is a process that considers factors such as current HPV test results, past screening outcomes, the patients' age, and whether they've had a hysterectomy or not. When Risk is Elevated, Prompt Action.If a patient's immediate risk of developing CIN 3 exceeds 4%, expedited treatment is typically recommended. This treatment may entail one of several procedures aimed at removing abnormal cervical tissue.Loop Electrosurgical Excision Procedure (LEEP): A common method that removes tissue using an electric wire loop. Cold Knife Conization: In this procedure, a scalpel removes a cone-shaped section of the cervix.Laser Cone Biopsy: This technique involves removing a cone-shaped section of tissue using a laser.Alternatively, healthcare providers may opt for treatment methods such, as cryotherapy, thermos-ablation, and laser ablation to eliminate abnormal tissue.And those procedures are typically out of the scope of family medicine, but many family doctors may perform them with the proper training and experience.When the risk is deemed low, Surveillance.Patients with a risk of CIN 3 below 4% are typically advised to undergo surveillance with HPV testing every 1-5 years. If HPV testing is not available cytology alone (Pap test) is considered acceptable.Special considerations for women.For women under 25, a cautious approach is taken. If a low-grade lesion (LSIL) is identified through cytology, it is recommended to repeat the test annually for two years. If two consecutive tests show normal results the patient can resume screening intervals based on age. However, if a high-grade lesion (HSIL) is detected, a colposcopy and biopsy are recommended. It should be noted that expedited treatment is generally not advised for this age group since many high-grade lesions may resolve spontaneously.For women over 25, the presence of low-grade lesions or persistent high-risk HPV often leads to recommendations for colposcopy and cervical biopsy.When a cervical biopsy shows adenocarcinoma in situ it is suggested to perform an excisional procedure to rule out invasive cancer. The next steps depend on the margins of the excised tissue; If the margins show positive results (indicating abnormal tissue remains) further excision is necessary to ensure clear margins. This may be followed by a hysterectomy due to the risk of residual disease. For individuals who have been treated for high-grade lesions there is still a risk of developing cervical cancer. Therefore, long-term surveillance is essential. Women over 25 should undergo HPV testing six months after treatment, then annually until three consecutive negative tests are obtained. Subsequently testing every three years is advised for 25 years. As for women under 25, cervical cytology should be done six months post-treatment. Then at six-month intervals until three consecutive negative results are achieved. Once they reach 25 years old, they should switch to HPV testing.As summary, HPV is the most common cause of cervical cancer, and screening must be implemented no matter what your zip code is because adequate screening can lead to a lower mortality. Remember that self-collection is an alternative for your patients, and it is FDA-approved if it is done in a healthcare setting. The ASCCP guidelines are very useful but difficult to memorize, so you can invest in the ASCCP phone app to provide accurate care for your patients. Thanks!References: 1. World Health Organization. HPV and Cervical Cancer Fact Sheet. 2024. Available online: https://www.who.int/en/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer (accessed on 10 August 2024).2. Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191-e203.3. Serrano B, Ibáñez R, Robles C, Peremiquel-Trillas P, de Sanjosé S, Bruni L. Worldwide use of HPV self-sampling for cervical cancer screening. Preventive Medicine. 2022;154:106900.4. Gupta S, Palmer C, Bik EM, et al. Self-sampling for human papillomavirus testing: increased cervical cancer screening participation and incorporation in international screening programs. Front Public Health. 2018;6:345033.5. Ubah C, Nwaneri AC, Anarado AN, Iheanacho PN, Odikpo LC. Perceived barriers to cervical cancer screening uptake among women of an urban community in South-eastern Nigeria. Asian Pac J Cancer Prev. 2022;23(6):1959-1965.6. Vega Crespo, B., Neira, V.A., Ortíz Segarra, J. et al.Barriers and facilitators to cervical cancer screening among under-screened women in Cuenca, Ecuador: the perspectives of women and health professionals. BMC Public Health 22, 2144 (2022). https://doi.org/10.1186/s12889-022-14601-y7.Olaza-Maguiña AF, De la Cruz-Ramirez YM. Barriers to the non-acceptance of cervical cancer screenings (Pap smear test) in women of childbearing age in a rural area of Peru. Ecancermedicalscience. 2019;13:901.8. Sharma M, Batra K, Johansen C, Raich S. Explaining correlates of cervical cancer screening among minority women in the United States. Pharmacy. 2022 Feb 15;10(1):30.9. Polman NJ, Ebisch RMF, Heideman DAM, et al. Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial. The Lancet Oncology. 2019;20(2):229-238.10. Costa S, Verberckmoes B, Castle PE, Arbyn M. Offering HPV self-sampling kits: an updated meta-analysis of the effectiveness of strategies to increase participation in cervical cancer screening. British Journal of Cancer. 2023 Mar 23;128(5):805-13.11. Perkins RB, Guido RS, Castle PE, et al. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis. 2020;24(2):102-131.12. Straughn, Jr, J Michael, and Catheryn Yashar. “Management of Early-Stage Cervical Cancer.” Www.uptodate.com, 2 Aug. 2024, https://www.uptodate.com/contents/management-of-early-stage-cervical-cancer. Accessed 13 Aug. 2024.13. AMBOSS GmbH.Cervical cancer screening. https://amboss.com/. Accessed August 18, 2024.14. Royalty-free music used for this episode: Lofi-Chilly by Gushito, downloaded on Nov 06, 2023, from https://www.videvo.net
Citations: Francesco Nepitello on Twitter: @FNepitelloThe One Ring by Free League Publishing: https://freeleaguepublishing.com/games/the-one-ring/ (Accessed August 27, 2024)War of the Ring strategy game by Ares Games: https://www.aresgames.eu/games/war-of-the-ring-line (Accessed August 27, 2024)
Eric and Glenn are back from a little summer break, prepping for the 2024 IAI Conference in Reno. They do a final “Where in the Whorld?” game. Then they jump into a recent paper on “Inconclusive” decisions (Swofford, et al. (2024) “Inconclusive Decisions and Error Rates in Forensic Science”, Forensic Science International: Synergy (vol 8; 100472)) authored by several members of NIST. The paper proposes a method for computing and communicating error rates when “inconclusive” decisions are made. The paper also focuses on making clear distinctions between “method performance” versus “method conformance”. The guys discuss their views on the method and the implications the paper may have for fingerprint examiners and their agencies. Swofford, H. , Lund, S. , Iyer, H. , Butler, J. , Soons, J. , Thompson, R. , Desiderio, V. , Jones, J. and Ramotowski, R. (2024), Inconclusive Decisions and Error Rates in Forensic Science, Forensic Science International: Synergy, [online], https://doi.org/10.1016/j.fsisyn.2024.100472, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=957335 (Accessed August 31, 2024) Link to open source paper here: https://doi.org/10.1016/j.fsisyn.2024.100472
Episode Notes Books: Crowley, Aleister. The Book of the Law. Weiser Books, 1976. https://www.amazon.com/Book-Law-Aleister-Crowley/dp/0877283346 Crowley, Aleister. The Confessions of Aleister Crowley: An Autohagiography. Arkana, 1989. https://www.amazon.com/Confessions-Aleister-Crowley-Autohagiography-Arkana/dp/0140191897 Crowley, Aleister. Magick in Theory and Practice. Dover Publications, 1976. https://www.amazon.com/Magick-Theory-Practice-Aleister-Crowley/dp/0486232952 Crowley, Aleister. The Book of Thoth: A Short Essay on the Tarot of the Egyptians. Weiser Books, 2019. https://www.amazon.com/Book-Thoth-Essay-Tarot-Egyptians/dp/0877282684 Sutin, Lawrence. Do What Thou Wilt: A Life of Aleister Crowley. St. Martin's Griffin, 2000. https://www.amazon.com/Do-What-Thou-Wilt-Aleister/dp/0312288972 Kaczynski, Richard. Perdurabo: The Life of Aleister Crowley. North Atlantic Books, 2010. https://www.amazon.com/Perdurabo-Life-Aleister-Crowley/dp/1556438990 King, Francis. The Magical World of Aleister Crowley. Weiser Books, 2004. https://www.amazon.com/Magical-World-Aleister-Crowley/dp/1578633292 Symonds, John. The Great Beast: The Life and Magick of Aleister Crowley. Macmillan, 1952. https://www.amazon.com/Great-Beast-Life-Magick-Crowley/dp/0595479532 Booth, Martin. A Magick Life: A Biography of Aleister Crowley. Coronet, 2001. https://www.amazon.com/Magick-Life-Biography-Aleister-Crowley/dp/0340728375 Churton, Tobias. Aleister Crowley in America: Art, Espionage, and Sex Magick in the New World. Inner Traditions, 2017. https://www.amazon.com/Aleister-Crowley-America-Espionage-Magick/dp/1620556526 Articles: McDonald, R. (2021). "Aleister Crowley: The Wickedest Man in the World." History Extra. https://www.historyextra.com/period/modern/aleister-crowley-the-wickedest-man-in-the-world/ Espinosa, M. (2019). "Aleister Crowley's Influence on Modern Magic." Smithsonian Magazine. https://www.smithsonianmag.com/history/aleister-crowleys-influence-on-modern-magic-180971848/ Churton, T. (2016). "Aleister Crowley, the Occult, and Rock & Roll." VICE. https://www.vice.com/en/article/9k5edz/aleister-crowley-the-occult-and-rock-roll Bogdan, H. (2012). "The Influence of Aleister Crowley on Kenneth Anger." Cinema Journal. https://muse.jhu.edu/article/472788 Pasi, M. (2009). "Aleister Crowley and the Temptation of Politics." Nova Religio: The Journal of Alternative and Emergent Religions. https://online.ucpress.edu/nr/article-abstract/12/3/4/70854/Aleister-Crowley-and-the-Temptation-of-Politics?redirectedFrom=fulltext Levy, M. (2004). "Aleister Crowley in the Desert: The Last Ritual of the Great Beast." Esoterica. https://www.esoteric.msu.edu/VolumeIV/Crowley.htm Websites: "The Aleister Crowley Foundation". Accessed August 20, 2024. http://www.aleistercrowleyfoundation.org/ "The Hermetic Order of the Golden Dawn - Aleister Crowley". Accessed August 20, 2024. Episode "Thelema: Aleister Crowley's Religious Philosophy". Accessed August 20, 2024. https://www.thelema.org/ "Ordo Templi Orientis (O.T.O.)". Accessed August 20, 2024. http://www.oto.org/ "Aleister Crowley: The Great Beast 666". Accessed August 20, 2024. https://www.aleister-crowley-666.com/ "The Boleskine House Foundation: Aleister Crowley's Legacy". Accessed August 20, 2024. https://www.boleskinehouse.org/ "Sacred Texts: Aleister Crowley". Accessed August 20, 2024. https://www.sacred-texts.com/oto/crowley.htm "Aleister Crowley on Thelemapedia". Accessed August 20, 2024. http://www.thelemapedia.org/index.php/Aleister_Crowley Find out more at https://three-minute-modernist.pinecast.co
As I was reading stuff online I came across an article from Roman Catholic apologist Dave Armstrong against William Lane Craig's defense of monothelitism.Armstrong blames Craig's error on Sola Scriptura and rejecting the "infallibility" of the Roman Catholic church.While I agree that Craig is wrong about monothelitism, I also believe Armstrong is wrong about why.This episode addresses both the error of monothelitism and the error of Roman Catholic epistemology. I believe Craig's philosophy is the problem. I also believe history disproves Armstrong's "infallible church" idea and that Scripture is the authority for determining who Jesus is.Sources Cited:William Lane Craig, "#75 Monotheletism," Reasonable Faith, September 22, 2008.Dave Armstrong, "William Lane Craig's Christological Errors (Monothelitism +)," Patheos, Updated April 5, 2018.Dave Armstrong, "Sola Scriptura Can't Definitively Refute Christological Heresy," Patheos, Updated June 14, 2020.William Lane Craig, "Does Christ Have Two Wills or One?" drcraigvideos, July 15, 2022, educational video, 0:07 to 0:56."Third Council of Constantinople (A.D. 680-681)," New Advent, Accessed August 18, 2024."Discourse I" in "Four Discourses Against the Arians (Athanasius)," New Advent, Accessed August 18, 2024."Gregory of Nazianzus - Critique of Apollinarius and Apollinarianism," Early Church Texts, Accessed August 18, 2024.Scriptures Referenced:Isaiah 53:11Galatians 3:132 Corinthians 5:211 Peter 3:18Acts 2:22,30-31Hebrews 1:2-3; 2:16-18; 4:14-15; 5:7-9James 1:13-14*** Castle Rock Women's Health is a pro-life and pro-women health care ministry. They need your help to serve the community. Please consider a monthly or one-time donation. ***We value your feedback!Have questions for Truthspresso? Contact us!
As I was reading stuff online I came across an article from Roman Catholic apologist Dave Armstrong against William Lane Craig's defense of monothelitism.Armstrong blames Craig's error on Sola Scriptura and rejecting the "infallibility" of the Roman Catholic church.While I agree that Craig is wrong about monothelitism, I also believe Armstrong is wrong about why.This episode addresses both the error of monothelitism and the error of Roman Catholic epistemology. I believe Craig's philosophy is the problem. I also believe history disproves Armstrong's "infallible church" idea and that Scripture is the authority for determining who Jesus is.Sources Cited:William Lane Craig, "#75 Monotheletism," Reasonable Faith, September 22, 2008.Dave Armstrong, "William Lane Craig's Christological Errors (Monothelitism +)," Patheos, Updated April 5, 2018.Dave Armstrong, "Sola Scriptura Can't Definitively Refute Christological Heresy," Patheos, Updated June 14, 2020.William Lane Craig, "Does Christ Have Two Wills or One?" drcraigvideos, July 15, 2022, educational video, 0:07 to 0:56."Third Council of Constantinople (A.D. 680-681)," New Advent, Accessed August 18, 2024."Discourse I" in "Four Discourses Against the Arians (Athanasius)," New Advent, Accessed August 18, 2024."Gregory of Nazianzus - Critique of Apollinarius and Apollinarianism," Early Church Texts, Accessed August 18, 2024.Scriptures Referenced:Isaiah 53:11Galatians 3:132 Corinthians 5:211 Peter 3:18Acts 2:22,30-31Hebrews 1:2-3; 2:16-18; 4:14-15; 5:7-9James 1:13-14See AlsoIs Jesus Like My Favorite Superhero? (Playlist feed)*** Castle Rock Women's Health is a pro-life and pro-women health care ministry. They need your help to serve the community. Please consider a monthly or one-time donation. ***We value your feedback!Have questions for Truthspresso? Contact us!
This week on Parallax, Dr Ankur Kalra welcomes Dr Marc Gerdisch to discuss a groundbreaking study on reducing opioid use after cardiac surgery. Dr Marc Gerdisch is the Chief of Cardiovascular and Thoracic Surgery and Co-Director of the Heart Valve Center and Atrial Fibrillation Program at Franciscan St. Francis Health. He is a senior partner at Cardiac Surgery Associates and a Clinical Assistant Professor of Thoracic and Cardiovascular Surgery at Loyola University Medical Center in Chicago. Dr Gerdisch shares insights into his research on rigid sternal fixation and enhanced recovery protocols, which have shown promising results in postoperative pain management and patient recovery. In this episode, Dr Kalra and Dr Gerdisch discuss the specifics of the study, including the four-cohort design and the steps taken to expedite opioid-free recovery. Dr Gerdisch also shares valuable advice on overcoming physician inertia and building a strong case for implementing such a programme, including cost-benefit analysis considerations. What motivated the study? How can a holistic approach to cardiac surgery recovery be implemented? What advice does Dr Gerdisch have for our listeners? Sources: Gerdisch MW, et al. Ann Thorax Surg 2024. Rigid Sternal Fixation and Enhanced Recovery for Opioid-Free Analgesia After Cardiac Surgery. DOI: 10.1016/j.athoracsur.2024.06.032 CE Cox. TCTMD 2024. Holistic Approach to Cardiac Surgery Can Sharply Cut Opioid Use. Available at: https://www.tctmd.com/news/holistic-approach-cardiac-surgery-can-sharply-cut-opioid-use. Accessed August 12, 2024.
In the early morning hours of June 4, 1904, New York City police were called to Lower Manhattan for what they were told was the death of Frank “Ceasar” Young from a self-inflicted gunshot wound to his chest. When they arrived at the scene, they found Young's body in the back of a Hansom cab, slumped over into the lap of a young actress named Nan Patterson, with whom he'd been having an affair. Nan claimed Young had shot himself when she refused to accompany him back to England, where he was headed to meet his wife that morning, but the police believed otherwise, and Nan was arrested and charged with Young's murder.What followed was not one, but three sensational murder trials that commanded the attention of New Yorkers across all five boroughs, and all of them had an opinion about Nan Patterson and her relationship with Caesar Young.Thank you to the fantastical David White, of Bring me the Axe podcast, for research assistance :)ReferencesAllen, Oliver. 2017. When today's Tribeca was the site of a most sensational murder. November 15. Accessed August 30, 2023. www.tribecatrib.com/content/when-todays-tribeca-was-site-most-sensational-murder.New York Times . 1904. "Nan Patterson hears the case against her." The New York Times, November 22: 6.New York Times. 1904. "Bookmaker is shot in cab with actress." New York Times, June 5: 1.—. 1904. "Actress recommitted at Jerome's insistance." The New York Times, June 7: 2.—. 1904. "Aged witness speaks for Nan Patterson." The New York Times, November 2: 16.—. 1904. "Allows Nan Patterson bail." The New York Times, September 2: 14.—. 1905. "Choose married men for Patterson case." The New York Times, April 19: 20.—. 1904. "Coroner says Nan Patterson is guilty." The New York Times, June 9: 2.—. 1905. "Disagreement in Patterson case." The New York Times, May 4: 1.—. 1905. "Indictment against Morgan Smiths quashed." The New York Times, May 6: 16.—. 1905. "Misdirected sympathy." The New York Times, January 2: 6.—. 1904. "Nan Patterson case results in mistrial." The New York Times, December 24: 14.—. 1905. "Nan Patterson Free." The New York Times, May 13: 3.—. 1905. "Nan Patterson free; Jerome blames press." The New York Times, May 13: 3.—. 1904. "Nan Patterson swears Young shot himself." The New York Times, December 20: 1.—. 1904. "Nan Patterson will not answer questions." The New York Times, June 10: 3.—. 1904. "Nan Patterson's trial to begin again Monday." The New York Times, November 29: 4.—. 1904. "New Patterson trial soon." The New York Times, December 25: 11.—. 1904. "Patterson counsel witness at trial." The New York Times, December 10: 16.—. 1904. "Rand highly praised for closing address." The New York Times, December 22: 6.—. 1904. "Rand springs surprise in Nan Patterson case." The New York Times, December 14: 16.—. 1904. "The Nan Patterson case, letter to the editor." The New York Times, December 30: 8.—. 1904. "Witness corroborates Hazelton's version." The New York Times, November 3: 16.—. 1904. "Witness ill, may halt Nan Patterson trial." The New York Times, November 19: 5.—. 1904. "Young, witness says, hit Nan Patterson." The New York Times, November 24: 4.New York Tmes. 1904. "Skeleton in court in Young case." The New York Times, November 23: 5.San Francisco Call. 1904. "'Caesar' Young, the Californian slain while riding in cab with actress." The San Francisco Call, June 5: 21.San Francisco Chronicle . 1904. "Young's death still puzzling." San Francisco Chronicle, June 6: 1.San Francisco Chronicle. 1904. "Young's death still puzzling." San Francisco Chronicle , June 6: 1.Segrave, Kerry. 2020. Death in a Hansom Cab; The 1904 Persecution of Nan Patterson. Cheltinham, UK: History Press.The Washington Times. 1904. "Nan Patterson's mother very ill." The Washington Times, June 6: 1.Woolcott, Alexander. 1930. "The mystery of the Hansom cab." The New Yorker, May 3: 36-44.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Shop Morbid coffee at www.deadsledcoffee.com and the Morbid Zodiac Mug Collection at www.wonderyshop.comIn the fall of 1961, Betty and Barney Hill took a trip to Niagara Falls. On the drive back from Canada to their home in Portsmouth, NH, the Hills claimed their trip was interrupted when, after stopping to investigate a strange flying object hovering above the car, the couple was abducted by what Barney later described as “beings [that] were somehow not human.”Thank you to the wondrous Dave White for Research Assistance!References:Friedman, Stanton, and Kathleen Marden. 2007. Captured! The Betty and Barney Hill UFO Experience. Red Wheel : Newburyport, MA.Palmer, Barry. 1965. "Portsmouth couple wes 600 persons here." Nashua Telegraph, December 1: 3.Public Broadcasting Sysetm. 1997. Nova: Kidnapped by UFOs? Boston, MA, April 1.Robinson, J. Dennis. 1999. "The Grounding of Betty Hill." The Portsmouth Herald, February 5.—. 2008. The UFO romance of Betty and Barney Hill. Accessed August 17, 2023. http://www.seacoastnh.com/the-ufo-romance-of-betty-and-barney-hill/?showall=1.The Portsmouth Herald. 1969. "Barney Hill dies in city at age 46." The Portsmouth Herald, February 26: 3.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In the summer of 1974, paranormal investigators and UCLA students Barry Taff and Kerry Gaynor were approached in a bookstore by a woman who'd overheard their conversation about the supernatural and said she had a friend who needed help from someone with their expertise. The friend in question was Doris Bither, a middle-aged single mother of four who claimed she and her family were under attack from unseen entities in their Culver City, California home. According to Doris, the attacks began several months earlier and included, among other things, objects moving on their own, the presence of inexplicable foul odors in the house, unusual noises with no point of origin, and most distressingly, multiple physical and sexual assaults that were increasing in frequency and intensity. Thank you to the lovely David White for research assistance :)ReferencesBiddle, Kenny. 2021. "A Closer Look at the Entity Photographs." Skeptical Inquirer 45 (6).O'Keeffe, Ciaran, James Houran, Damian Houran, Neil Dagnall, Kenneth Drinkwater, Lorraine Sheridan, and Brian Laythe. 2019. "The Dr. John Hall story: a case study in putative “Haunted People Syndrome"." Mental Health, Religion & Culture 22 (9): 910-929.Ortega, Xavier. 2011. The Real Entity Case, Part II. August 6. Accessed August 23, 2023. https://www.ghosttheory.com/2011/08/06/the-real-entity-case.Radford, Benjamin. 2021. "The ‘True' Story behind The Entity: Untangling Hollywood Horror." Skeptical Inquirer 45 (6). https://skepticalinquirer.org/2021/10/the-true-story-behind-the-entity-untangling-hollywood-horror/.2005. The Entity Files. Directed by Perry Martin. Produced by Anchor Bay Entertainment. Performed by Barry Taff.—. 2011. The Real Entity Case. August. Accessed August 24, 2023. http://barrytaff.net/2011/08/the-real-entity-case-2/.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In the depths of American history there are few examples of mass hysteria that loom larger than the Salem witch trials of 1692. As horrific as it was, it was far from the only example of witch-hunting in Massachusetts' history. In fact, ten years before hysteria over black magic gripped the village of Salem, similar accusations of witchcraft were aimed at Mary Webster of Hadley, a small village in Western Massachusetts. Thank you to the incredible Dave White for Research assistance.ReferencesClancy, Hal. 1977. "In good old days, wicthes would hang for a May snow." The Boston Globe, May 14: 1.Judd, Sylvester. 1905. History of Hadley. Springfield, MA: H.R. Hunting.Manning, Alice. 1976. "Witches in the Connecticut Valley: a historical perspective." Daily Hampshire Gazette, December 15: 35.Marshall, Bridget. 2003. "Mary (Reeve) Webster, the "Witch" of Hadley." University of Massachusetts Lowell. Accessed August 28, 2023. https://faculty.uml.edu//bmarshall/Mary%20Webster.htm.Mather, Cotton. 1967. Magnalia Christi Americana. New York, NY: Russell and Russell.Perera, Lisa. 1992. "Before Salem, Valley had witch trials of its own." Daily Hampshire Gazette, May 16: 22.Smith, Anna. 2019. The Witch of Hadley: Mary Webster, the Weird, and the Wired. October 15. Accessed August 28, 2023. https://www.massreview.org/node/7575.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
In this episode, we briefly review RSV (respiratory syncytial virus) infections and focus on new data supporting the use of two different RSV vaccines (Abrysvo and Arvexy) in preventing RSV infections in older adults and in pregnant women. Key Concepts RSV is a contagious respiratory virus that is usually mild and self-limiting in most patients but can cause severe disease especially in young children or older adults with certain risk factors. The FDA recently approved two vaccines for RSV (Abrysvo from Pfizer and Arexvy from GSK). The initial FDA approval was for adults 60 years of age and older; however, the FDA recently granted an additional indication for Abrysvo for pregnant women (to prevent the infant from severe RSV infection once born). When studied in older adults, both vaccines did meet efficacy criteria but the incidence of RSV infection was relatively low and thus the number needed to treat (NNT) is high. Both studies were done at times with lower RSV prevalence - the NNT would likely be more favorable during RSV outbreaks. Unlike Abrysvo, Arvexy (GSK) contains an adjuvant to improve the immune response. Although direct comparisons of efficacy and safety are not appropriate, Arvexy does appear to elicit more systemic adverse effects such as fever, myalgias, headache, and fatigue. References Respiratory Syncytial Virus Infection (RSV). Centers for Disease Control and Prevention. https://www.cdc.gov/rsv/index.html Abrysvo (respiratory syncytial virus vaccine). US Food & Drug Administration. https://www.fda.gov/vaccines-blood-biologics/abrysvo Arexvy (respiratory syncytial virus vaccine, adjuvanted). US Food & Drug Administration. https://www.fda.gov/vaccines-blood-biologics/arexvy Use of Respiratory Syncytial Virus Vaccines in Older Adults: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023. Morbidity and Mortality Weekly Report (MMWR). July 21, 2023 / 72(29);793-801. https://www.cdc.gov/mmwr/volumes/72/wr/mm7229a4.htm CDC. ACIP Recommendations. Last reviewed August 4, 2023. www.cdc.gov/vaccines/acip/recommendations.html. Accessed August 23, 2023. RENOIR - Walsh EE, Pérez Marc G, Zareba AM, et al. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults. N Engl J Med. 2023;388(16):1465-1477. doi:10.1056/NEJMoa2213836 AReSVi-006 - Papi A, Ison MG, Langley JM, et al. Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults. N Engl J Med. 2023;388(7):595-608. doi:10.1056/NEJMoa2209604 MATISSE - Kampmann B, Madhi SA, Munjal I, et al. Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants. N Engl J Med. 2023;388(16):1451-1464. doi:10.1056/NEJMoa2216480 RSV-NET Interactive Dashboard. Centers for Disease Control and Prevention. https://www.cdc.gov/rsv/research/rsv-net/dashboard.html ACIP Meeting Information - Meeting Materials. https://www.cdc.gov/vaccines/acip/meetings/index.html
On the morning of December 31, 1946, nineteen-year-old Pearl Lusk boarded a crowded subway train in Brooklyn. A few days earlier, she'd met a man named Allen in a bar who offered her a very strange, yet simple job: she was to follow a young woman named Olga and take a photo to determine whether she was wearing any stolen jewelry. That morning, as Pearl and Olga exited the crowded subway train, Pearl raised the camera in Olga's direction and pulled the wire to take a photo, but what happened next would put into motion a series of events that rivals fiction.Thank you to the wonderful Dave White for Research assistance!ReferencesAdams, Toni. 1947. "Troopers hunt and kill Alphonse Rocco." Kingston Daily Freeman, January 7: 1.Brooklyn Daily Eagle. 1947. "Camera-gun suspect flees in stolen car." Brooklyn Daily Eagle, January 6: 2.Buffalo Evening News. 1947. "'Camera' shooting victim asks N.Y. City to pay her $200,000." Buffalo Evening News, February 14: 1.—. 1953. "Court frees city of liability for not averting shooting." Buffalo Evening News, April 22: 25.—. 1947. "Police press quest for spouse of camera-gun victim." Buffalo Evening News, January 2: 9.—. 1946. "Times Square Station is scene of shooting." Buffalo Evening News, December 31: 10.International News Service. 1947. "Estranged wife and family glad Ruocco is dead." Buffalo Evening News, Janaury 7: 1.Kingston Daily Freeman. 1947. "Victim of camera shooting guarded." Kingston Daily Freeman, January 2: 18.McKelway, St. Clair. 1953. The Perils of Pearl and Olga. August 8. Accessed August 10, 2023. https://www.newyorker.com/magazine/1953/08/08/the-perils-of-pearl-and-olga.New York Times. 1947. "Camera-gun victim files for $200,000." New York Times, February 15: 17.—. 1947. "'Camera-gun' victim loses a leg." New York Times, Janaury 3: 1.—. 1947. "Girl, dupe in plot, shoots woman with 'camera' gun." New York Times, January 1: 1.—. 1947. "Lusk girl freed; will leave city." New York Times, Janaury 11: 20.—. 1947. "Rocco killed by the police in Catskills." New York Times, January 7: 1.Smith, Delos. 1947. "Gullible girl hoaxed into plot on life of estranged wife." Daily Boston Globe, January 1: 13.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In the spring of 2009, Edwin Gonzalez and his girlfriend, Lillian Otero, fled their house in Gardner, MA, less than one year after moving into what they believed was their dream home. Later, once they were safely away from the old Victorian, Gonzalez and Otero would explain to friends and family that they had been driven out by angry ghosts who had done everything—including possessing Lillian—in order to torment them, leaving them no other options than to abandon the house that had once held such promise. Although they didn't know it when they moved in, Gonzalez and Otero's home, the S.K. Pierce Mansion, had long been considered by locals to be haunted. Indeed, in its more than one-hundred-year history, the Victorian home had seen more than its fair share of tragedies, including several deaths in the house as recent as the 1960s, as well as countless other unsavory myths and legends.Thank you to Dave White for research assistance. ReferencesCity of Gardner. n.d. History. Accessed August 1, 2023. https://www.gardner-ma.gov/316/History.Discovery Channel. 2013. "Haunted Victorian." A Haunting. New York, NY: Discovery Channel, October 19.Farragher, Thomas. 2022. "Want to be a ghost host? Come to Gardner." Boston Globe, August 20: B1.Fiorentino, Alyssa. 2021. How the S.K. Pierce Mansion became one of the most haunted homes in Massachusetts. October 27. Accessed July 31, 2023. https://www.housebeautiful.com/lifestyle/a38046654/sk-pierce-haunted-victorian-mansion/.Fitchburg Sentinel. 1963. "Gardner man, 47, dies in room fire." Fitchburg Sentinel, April 9: 11.—. 1891. "Notes." Fitchburg Sentinel, December 8: 2.Gelinas, Brian. 2012. "Group of ghost hunting enthusiasts converge on Gardner mansion." Athol News, October 6: 1.Gershon, Livia. 2006. Ghost hunters. July 28. Accessed August 1, 2023. https://www.thegardnernews.com/story/news/2006/07/28/ghost-hunters/11341583007/.Ilinitch, Shawn. 2003. Psychic profiler detects spirits in South Gardner home. October 31. Accessed August 1, 2023. https://www.thegardnernews.com/story/news/2003/11/01/psychic-profiler-detects-spirits-in/11284159007/.Landry, Stephen. 2021. "Debunking rumors about the S.K. Pierce Mansion." Gardner News, September 22.—. 2020. "New book details history of S.K. Pierce Mansion." Gardner News, September 25.Pelletiere, Nicole. 2016. Homeowner to turn 'haunted' mansion into scary attraction. September 2. Accessed August 1, 2023. https://abcnews.go.com/Lifestyle/homeowner-turn-haunted-mansion-scary-attraction/story?id=41769810.SK Haunted Victorian Mansion. 2023. The Mansion. Accessed August 2, 2023. https://www.skhauntedvictorianmansion.com/index.html.Stanway, Eric. 2013. The Victorian. September: Independent.—. 2013. "Gardner mansion shelters ghostly past." Worcester Telegram and Gazette, July 10.Zillow. 2023. 4 West Broadway, Gardner, MA. Accessed August 1, 2023. https://www.zillow.com/homedetails/4-West-Broadway-Gardner-MA-01440/57587523_zpid/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Meet sisters Caroline Martin, Virginia Wardlaw and Mary Snead. They left a long trail of devastation and death of family members from Kentucky to Tennessee and Virginia on to New Jersey where they were implicated in the mysterious death of a young family member. Want more Southern Mysteries? Hear the Southern Mysteries show archive of 60+ episodes along with Patron exclusive podcast, Audacious: Tales of American Crime and more when you become a patron of the show. You can immediately access exclusive content now at patreon.com/southernmysteries Connect Website: southernmysteries.com Facebook: Southern Mysteries Podcast Twitter: @southernpod_ Instagram: @shannonballard_ Email: southernmysteriespodcast@gmail.com Episode Sources “Soule Sisters Series”, Daily News Journal, Sunday, October 2009. Accessed March 2, 2028. https://rutherfordtnhistory.org/rutherford-county-hosted-three-wicked-witches/ “Three Sisters in Black: The Bizarre True Case of the Bathtub Tragedy” by Norman Zierold. Accessed March 1, 2018. https://books.google.com/books?id=wqdLDwAAQBAJ&printsec=frontcover#v=onepage&q&f=false “Ghosts of past still frighten New River Valley”, Collegiate Times, October 31, 2006. Accessed March 10, 2018. https://www.collegiatetimes.com/lifestyle/ghosts-of-past-still-frighten-new-river-valley/article_0b71ec43-ff02-5af4-a83e-8016c081891a.html “Sister Act: The Bizarre Drowning of Ocey Snead”, The Lineup, July 19, 2018. Accessed August 1, 2023. https://the-line-up.com/the-bizarre-drowning-of-ocey-snead Episode Music Theme Song “Dark & Troubled” by Pantherburn. Special thanks to Phillip St Ours for permission for use. Colorless Aura by Kevin MacLeod. Licensed under Creative Commons.
In the summer of 1980, nineteen-year-old Nancy Santomero, and two friends, twenty-six-year-old Vicki Durian and nineteen-year-old Liz Johndrow, left Durian's parents' home in Iowa to hitchhike to West Virginia to attend a gathering of the Rainbow Family. Five days later, Santomero and Durian's bodies were discovered in the woods in West Virginia, shot to death just hours before being found, and Johndrow was nowhere to be seen.More than a decade after their bodies were discovered, police in West Virginia had identified several suspects and eventually charged thirty-four-year-old farmer Jacob Beard, who was convicted in 1993 and sentenced to life in prison. Upon appeal, however, it was revealed that the investigation into Beard was rife with dubious circumstantial evidence, police misconduct, and perjury, which led to a new trial and Beard was exonerated. Thank you to the lovely Dave White for research assistanceReferences: Associated Press. 1992. "W. Va drops Rainbow charges." Roanoke Ties and World-News, July 21: 6.—. 1992. "Arrests in women's deaths 'witch hunt' attorney says." The Daily Progress , April 25: 7.—. 2000. "Jury finds man innocent in Rainbow murder trial." The Roanoke Times, June 1: 21.Behrens, David. 2000. "Too many years without answers." Newsday, February 16: B6.Daily Press. 1980. "2 murdered women in 'Rainbow Family'." Daily Press, June 27: 44.Danville Reigister and Bee. 1993. "Jury deliberating in slayings case." Danville Register and Bee, June 4: 10.Darling, Lynn. 1980. The Rainbow People. July 7. Accessed August 7, 2023. https://www.washingtonpost.com/archive/lifestyle/1980/07/07/the-rainbow-people/80aadbf3-ef61-4d43-9d62-766d4d01fc56/.Horn, Dan. 1997. "Franklin's boasting may unlock convict." The Cincinnati Post, April 18.Lovegrove, Richard. 1980. "Rainbow camp still going up despite slaying of women." The Roanoke Times, June 28: 1.—. 1980. "Two women slain near 'Rainbow' camp remain unidentified." The Roanoke Times, July 10: B-8.Possley, Maurice. 2012. Jacob Beard. July 30. Accessed August 8, 2023. https://www.law.umich.edu/special/exoneration/Pages/casedetail.aspx?caseid=3963.State of West Virginia v. Jacob W. Beard. 1998. 24644 (Supreme Court of Appeals of West Virginia, July 15).State of West Virginia v. Jacob W. Beard. 1995. 22504 (Supreme Court of Appeals of West Virginia, January).The Gazette. 1983. "2 West Virginia men charged in death of Wellman woman." The Gazette, April 8: 14.—. 1992. "4 charged in Wellman woman's 1980 slaying." The Gazette, April 17: 10.United Press International. 1980. "Young woman who skipped tragic hitchhiking trip found." The Daily Progress, July 17: 7.Wallace, Terry. 1992. "Seething hostility led to killing of hitchhikers." The Daily Progress, April 20: 1.West Virginia Public Broadcasting. 2020. Two Women Murdered Traveling to Rainbow Gathering. June 25. Accessed August 8, 2023. https://wvpublic.org/june-25-1980-two-women-murdered-traveling-to-rainbow-gathering/.https://kmbllaw.com/dont-just-ask-to-suppress-the-involuntary-statement-and-the-evidence-thats-fruit-of-the-poisonous-tree-ask-for-a-full-kastigar-hearing/#:~:text=In%20other%20words%2C%20the%20Kastigar,compelled%20after%20an%20immunity%20order.https://www.upcounsel.com/legal-def-habeas-corpus#:~:text=The%20writ%20of%20habeas%20corpus%20serves%20as%20an%20important%20check,290%2D91%20(1969).See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Otto Wood was a self–proclaimed one armed-bandit from North Carolina. He made a name for himself as a bootlegger who loved stealing from the rich. Being sent to jail only heightened his fame. He escaped prison so many times he was nicknamed the Hillbilly Houdini. Want more Southern Mysteries? Hear the Southern Mysteries show archive of 60+ episodes along with Patron exclusive podcast, Audacious: Tales of American Crime and more when you become a patron of the show. You can immediately access exclusive content now at patreon.com/southernmysteries Connect Website: southernmysteries.com Facebook: Southern Mysteries Podcast Twitter: @southernpod_ Instagram: @shannonballard_ Email: southernmysteriespodcast@gmail.com Episode Sources ‘They started popping bullets': Eyewitness recalls the day Otto Wood died. Salisbury Post. January 2015. Accessed August 1, 2023. https://www.salisburypost.com/2015/07/30/they-started-popping-bullets-eyewitness-recalls-the-day-otto-wood-died/ Wood, Otto. Life history of Otto Wood: inmate, State Prison. Raleigh, N.C.: 1926. Otto Wood: North Carolina's One Man Crime Wave. Old Hat Records. Accessed August 3, 2023. http://www.oldhatrecords.com/ResearchOttoWood.html The not too well-known desperado. Accessed August 3, 2023. http://kronsell.net/woodenglish.htm McKenzie, T. (2021). Otto Wood, the Bandit: The Freighthopping Thief, Bootlegger, and Convicted Murderer behind the Appalachian Ballads. University of North Carolina Press. http://www.jstor.org/stable/10.5149/9781469665672_mckenzie Episode Music The Colonel by Zachariah Hickman. Licensed under Creative Commons; Otto Wood: The Bandit by The Carolina Buddies, Columbia Phonograph Recordings, 1931. Theme Song “Dark & Troubled” by Pantherburn. Special thanks to Phillip St Ours for permission for use.
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