Sapio with Buck Joffrey

Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutraceuticals and therapeutic plasma exchange. The discussion also touches on the future of aging research, emphasizing personalized approaches and the democratization of diagnostics. Learn more about Dr. David Furman: https://www.buckinstitute.org/lab/furman-lab/

In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process. Dr. Walker also explores the implications of her research for cognitive health, particularly in the context of neurodegenerative diseases, and the potential therapeutic strategies that could arise from understanding neurogenesis better.

Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity, how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype reveals about your ideal sleep patterns. From the effects of sleep deprivation on metabolism and aging to natural sleep tips, supplements, and cutting-edge alternatives to CPAP machines for sleep apnea, this conversation is packed with actionable advice to boost your sleep quality and your longevity. Learn more about the Sleep Doctor, Dr. Michael Breus: https://sleepdoctor.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity. Learn more about Dr. Joan Mannick: https://www.linkedin.com/in/joan-mannick-8089a614/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis, the truth about sun exposure vs. supplements, and why vitamin D deficiency is far more common—and more dangerous—than most people realize. You'll learn how skin pigmentation, UVB exposure, and supplementation protocols impact your vitamin D levels, and why D3 is more effective than D2. Dr. Holick also dives into mood, cognition, and the controversial role of vitamin D in chronic disease and COVID outcomes. With dosage guidelines by age and weight, plus practical advice on avoiding vitamin D toxicity, this episode is a masterclass on one of the most important—yet misunderstood—nutrients in health and longevity. Learn more about Dr. Michael F. Holick: https://drmichaelholick.org/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST)—a powerful yet quick tool to assess cognitive health—and shares insights from decades of evaluating memory, dementia, brain injuries, and CTE. From preventive strategies that could reduce dementia risk by nearly 50%, to how technology is transforming neuropsychology, this conversation is a must-watch for anyone invested in long-term brain health. Learn more about Dr. Mitchell Clionsky: https://www.linkedin.com/in/mitchell-clionsky-4b8b275b/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

What if your body already had everything it needs to heal itself—naturally? In this episode, neurophysiologist and stem cell researcher Dr. Christian Drapeau breaks down the science of stem cell therapy, explaining how adult stem cells, embryonic stem cells, and exosomes play a central role in regenerative medicine and longevity. Discover how aging affects the body's ability to mobilize stem cells, how injury signals guide them, and why immune system function is tightly linked to stem cell activity.  Learn more about Dr. Christian Drapeau and STEMREGEN: https://tinyurl.com/kmvp5972 - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Learn how pharmacological interventions could unlock new possibilities for health, longevity, and immune rejuvenation. Learn more about Dr. Alessio Lanna: https://sentcell.life/team/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Are your mitochondria aging faster than you are? In this episode, Dr. Mark Tarnopolsky breaks down the central role of mitochondria in aging, longevity, and overall metabolic health. Learn how mitochondrial dysfunction drives age-related decline, including neurodegenerative diseases, and what you can do about it. From the paradox of oxidative stress to the risks of overusing antioxidants, this conversation unpacks what actually supports mitochondrial health—including a clinical “mitochondrial cocktail” targeting multiple aging pathways. Dr. Tarnopolsky also explains how exercise, nutrition, VO2 max, and exokines impact your healthspan, plus why most therapeutics miss the mark. Learn more about Dr. Mark Tarnopolsky: https://experts.mcmaster.ca/display/tarnopol

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Dr. Michael Gershon—legendary Columbia professor and author of The Second Brain—joins us to explain why your intestines might just be running the show. From guinea pig guts that "blew back" to the real reason stress wrecks your digestion, this episode dives deep into the mysterious world of the enteric nervous system. Prepare for gut science, serotonin surprises, and a Woody Allen–esque dose of humor from the father of neurogastroenterology himself. Learn more about Dr. Michael Gershon: https://www.pathology.columbia.edu/profile/michael-d-gershon-md Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights for anyone serious about optimizing fitness, metabolism, and longevity. Learn more about Dr. Keith Baar: https://health.ucdavis.edu/physiology/faculty/baar.html

Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for humans. Dr. Venn-Watson explains how C15 deficiency can accelerate aging, increase the risk of fatty liver disease, and contribute to cellular fragility syndrome and ferroptosis, a newly discovered form of cell death linked to iron overload. We dive into clinical trials on C15 supplementation, its impressive health benefits, and why this saturated fat may be a game-changer for nutrition and aging. Discover why dolphin research is reshaping our understanding of essential fatty acids and why C15 could be the key to addressing the silent epidemic of C15 deficiency. Whether you're interested in longevity, epidemiological studies, or cutting-edge clinical trials, this episode offers actionable insights into the future of health and nutrition. Curious to learn more? Grab Dr. Venn-Watson's new book, The Longevity Nutrient: The Unexpected Fat That Holds the Key to Healthy Aging, and explore the groundbreaking science behind C15 and its potential to revolutionize your health: https://fatty15.com/ Ready to experience the benefits of C15 yourself? Dr. Venn-Watson is offering our audience an exclusive 20% off your first order at: fatty15.com/LONGEVITYROADMAP

Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics most at risk, the physiology behind depression and suicidal thoughts, and the critical role of reducing stigma around mental health. Dr. Franz offers practical insights for recognizing warning signs, improving treatment access, and understanding future strategies to personalize suicide prevention.

Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland's role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that thymus regeneration in humans is possible—and may even turn back the clock on biological aging. Dr. Fahy also explores how growth hormone plays a role in reversing age-related thymic decline, the controversies around its use, and why insulin sensitivity is critical for healthy aging. Plus, we discuss cutting-edge regenerative medicine approaches like cryopreservation for organ preservation and transplantation—and what this means for the future of human longevity. If you're interested in immunology, anti-aging breakthroughs, and regenerative medicine, this episode is packed with insights on how reprogramming the thymus could unlock longer, healthier lives.

Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland's role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that thymus regeneration in humans is possible—and may even turn back the clock on biological aging. Dr. Fahy also explores how growth hormone plays a role in reversing age-related thymic decline, the controversies around its use, and why insulin sensitivity is critical for healthy aging. Plus, we discuss cutting-edge regenerative medicine approaches like cryopreservation for organ preservation and transplantation—and what this means for the future of human longevity. If you're interested in immunology, anti-aging breakthroughs, and regenerative medicine, this episode is packed with insights on how reprogramming the thymus could unlock longer, healthier lives.

Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product efficacy, and the broader systemic benefits of optimizing skin health. Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/  

Buck Joffrey welcomes Dr. Michael Miller and Dr. Jacob Allen for an in-depth discussion on gut health and its vital role in overall well-being. They explore the gut microbiome's composition, how diet and lifestyle influence its dynamic nature, and the significance of fermented foods and dietary bioactives. The conversation also tackles the controversial topic of leaky gut syndrome, common misconceptions about gut health, and the potential benefits of probiotics. Dr. Allen and Dr. Miller further break down the complexities of leaky gut, its triggers, and the intricate relationship between stress, exercise, and the microbiome. They highlight the gut-brain axis, the critical role of dietary fiber, and the importance of a diverse diet rich in fiber and fermented foods to support gut integrity and long-term health. Learn more about Dr. Allen and Dr. Miller:  https://nutrsci.illinois.edu/directory/jmallen5 https://fshn.illinois.edu/directory/mille216   Questions? Send us a message: https://www.longevityroadmap.com/   Follow us on social media: https://linktr.ee/longevityroadmap  

Dr. Robert Lustig joins Buck to discuss the alarming state of metabolic health in America, where only 7% of the population is considered metabolically healthy. He breaks down metabolic dysfunction, linking it primarily to mitochondrial inefficiency, and explains how sugar—especially fructose—plays a major role in various health issues. The conversation explores the dangers of ultra-processed foods, identifying key contributors to metabolic dysfunction, including excessive sugar, insufficient fiber, and emulsifiers in processed foods. Dr. Lustig also examines the impact of hyperinsulinemia, the effects of fructose on liver health, and the role of branched-chain amino acids in metabolism. Beyond diet, he highlights the importance of understanding how insulin, amino acids, and mitochondrial function influence overall metabolic health. The discussion touches on inflammation, the challenges of making healthy choices in grocery stores, and the pros and cons of different diets, including ketogenic and carnivore diets. Lustig also underscores the significance of fasting insulin as a key marker of metabolic dysfunction and explores how nutraceuticals can support mitochondrial health. Learn more about Dr. Robert Lustig: https://robertlustig.com/ PERFACT – A tool for filtering healthier grocery items: http://perfact.co Blue Oak Nutraceuticals – Maker of Mitocatalyst E: https://blueoaknx.com

In this episode, Dr. Vera Gorbunova joins us to discuss her pioneering research in aging science, focusing on comparative biology and the mechanisms of longevity found in exceptionally long-lived species like the naked mole rat and bowhead whale. She explains the importance of translational research, DNA repair mechanisms, the role of transposable elements in aging, and the impact of epigenetics on lifespan. Dr. Gorbunova also highlights mitochondrial function and its relation to longevity, as well as the potential for gene therapy and pharmacological interventions to extend human lifespan.

In this episode, Dr. Vera Gorbunova unpacks the secrets of nature's longest-lived species—like the naked mole rat and bowhead whale—to uncover the biological mechanisms that keep them healthier for longer. We explore the role of DNA repair, transposable elements, and epigenetics in aging and what these discoveries could mean for human longevity. From mitochondrial function to promising interventions like fucoidan, can we apply nature's blueprint to extend our own lifespan?

Buck Joffrey interviews Professor Andrea B. Maier, a leading expert in geroscience and healthy aging. They discuss the evolution of longevity research, the importance of distinguishing between lifespan and healthspan, and the biological mechanisms of aging. Professor Maier emphasizes the need for precision medicine in interventions and the challenges of supplement quality. They also explore future technologies in longevity research, practical steps for individuals to assess their biological age, and the significance of guidelines in healthy longevity medicine.

In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity, and explore the limitations of direct NAD infusions. The conversation concludes with insights into NAD precursors like NMN and NR, which can help increase NAD levels in the body.  Dr. Conlon is offering our listeners a special 20% discount on first purchase at www.nuchido.com. Use the code SAPIO20.

Buck and Nikki sit down with Dan Buettner, creator of the Netflix series Live to 100: Secrets of the Blue Zones, to explore the wisdom of the world's longest-lived populations. They dive into the lifestyle, diet, and environmental factors that contribute to longevity, and how you can engineer these principles to extend your healthy lifespan.

This week on Longevity Roadmap, Buck showcases standout moments from Longevity Junky—another health-focused podcast he co-hosts with actress and model Nikki Leigh. Designed for a broader audience, Longevity Junky makes longevity concepts accessible while delivering valuable insights. Tune in for a curated selection of engaging topics, complete with Buck's commentary, offering fresh perspectives not covered on Longevity Roadmap.

Buck Joffrey interviews Martin Gibala, a professor at McMaster University, about High-Intensity Interval Training (HIIT) and its benefits. They discuss the definition of HIIT, its physiological mechanisms, and how it compares to traditional exercise. The conversation also covers the implications of HIIT for different populations, its connection to VO2 max and longevity, practical applications in daily life, safety considerations, and resources for further learning. 00:00 - Introduction to High-Intensity Interval Training (HIIT) 04:39 - Physiological Mechanisms of HIIT vs. Traditional Exercise 08:34 - HIIT for Different Populations and Health Benefits 12:30 - VO2 Max and Longevity: The HIIT Connection 16:30 - Practical Applications of HIIT in Daily Life 20:37 - Safety and Considerations for HIIT Training 24:31 - Conclusion and Resources for Further Learning

In this wholesome conversation, Buck and Dr. Ellen Langer discuss the profound connection between the mind and body, emphasizing the importance of mindfulness in health and aging. She shares insights from her groundbreaking studies, including the counterclockwise study, which demonstrated that altering one's mindset can lead to significant health improvements. The discussion also explores how perception influences physical attributes, the detrimental effects of mindlessness, and the potential for mindfulness to enhance longevity and overall well-being.  00:00 - The Mind-Body Connection and Health Paradigms 06:08 - Perception and Health: The Power of Mindset 12:09 - Mindlessness: The Root of Our Problems 19:36 - Understanding Mindfulness 27:52 - The Power of Placebo 36:20 - Harnessing Mindfulness for Longevity

In this episode, Buck Joffrey discusses the importance of going beyond the normal scope of testing when it comes to lipid profiles and cardiovascular health management. He emphasizes the significance of understanding cholesterol particles, particularly APO-B, and lipoprotein(a), in assessing heart disease risk. He also highlights preventative strategies to optimize health and mitigate risks associated with cardiovascular disease.

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies. 00:00 - Introduction to Longevity Roadmap 03:08 - Case Study: A 70-Year-Old Patient's Health 12:07 - Understanding Lipid Management and Atherosclerosis 19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

Hey Sapio Fans, I've got something really exciting for you today—a chance to win a full-body MRI worth $2,500! This giveaway comes from my new podcast, Longevity Junky (that's junky with a Y). It's a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity. This week's episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—before they pose a serious threat to your health. Here's how you can enter to win this $2,500 Prenuvo MRI scan for free: Go to Apple Podcasts and find the Longevity Junky podcast (that's "Junky" with a Y). Leave a five-star review for the podcast. Subscribe to the podcast. Take a screenshot of your review. Visit LongevityJunky.com (again, "Junky" with a Y). Send the screenshot of your review along with a brief explanation of why you'd like a full-body MRI. Winners will be announced in 2 weeks—stay tuned and good luck to everyone!

An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where living to 1000 might just be possible.

This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love. The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It's no exaggeration to say this course has already saved years of good-quality life. This year, why not give the ultimate gift—the gift of health and time? Imagine helping a loved one discover a brighter, healthier future with a life-changing resource tailored to empower them for decades to come. Black Friday & Cyber Monday Special: For a limited time, I'm offering 20% off the Longevity Roadmap Course, which includes three months of biweekly one-on-one coaching with me. This offer is good through Cyber Monday, so don't wait—act now! The tools, science, and coaching included in this course can: Help prevent or reverse common conditions like heart disease and diabetes. Unlock strategies to add years of vibrant, good-quality life. Give peace of mind knowing you or your loved one is on the best path forward. This isn't just an investment in health—it's an investment in time with the people who matter most. Make this holiday season truly unforgettable by giving a gift that will last a lifetime—or longer. Sign Up Now and Use the Coupon Code Blackfriday2024 at Checkout to Get 20% Off – Offer Ends Cyber Monday! Here's to a longer, healthier, and happier future—for you and your loved ones. – Buck   P.S. Want to learn more? Book a call with me on longevityroadmap.com and let's talk!

Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market. 

In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet across the lifespan.

Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management. 04:51 Understanding Cholesterol: Beyond Good and Bad   08:25 Key Lab Tests for Lipid Management   11:12 The Role of Apolipoprotein B in Cardiovascular Health   14:44 The Complexities of HDL and Its Functions   19:11 The Misconceptions Around LDL and HDL Ratios   34:42 Pharmacotherapy: Statins and Beyond

  Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos' innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science, from the controversies around resveratrol to mitophagy's role in cellular health, the complexities of supplement dosages, and the potential of aging biomarkers and AI-driven research for consumer longevity solutions. Learn more about Dr. Barardo and NOVOS: https://novoslabs.com/ 00:00 Introduction to Longevity Research and Novos   02:04 Understanding Biological and Epigenetic Aging   09:20 The Drug Age Database and Its Significance   10:37 Longevity Compounds and Their Efficacy   20:58 The Role of Lithium and NAD Precursors   26:44 The Role of Mitochondria in Aging   36:14 Leveraging AI in Longevity Research

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body's nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there's a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity. 00:00  The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance

  Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body's autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health. 00:12 What is Heart Rate Variability? 05:34 The Normal Range of HRV 08:39 Contributing Factors that Impact Your HRV 23:18 Tactics to Improve HRV

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID. 02:07 What are Mitochondria? 05:05 Mitochondrial Dysfunction and Aging 12:13 Mitochondrial Genetics and Inheritance 14:54 Innovative Approaches to Mitochondrial Health 17:58 Pharmaceuticals and Supplements for Mitochondrial Support

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, ass well as practical steps to minimize exposure to microplastics in daily life.

In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton. Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/ Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw Questions? Send us a message at: www.longevityjunky.com Follow us on social media: Instagram: https://www.instagram.com/longevityjunkypodcast Facebook: https://www.facebook.com/profile.php?id=61564965475593 Twitter: https://x.com/longevity_junky Tiktok: https://www.tiktok.com/@longevityjunkypodcast

Buck introduces his brand new podcast, Longevity Junky. In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life. 00:13 The Definition of Flow 04:05 How Do We Have Flow? 08:25 Gettign In and Out of Flow 14:07 Mindfulness vs Flow   

Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He describes his surgical experience and the use of a gas bubble to reattach the retina. 

Buck discusses the role of big Tech and the elderly with Keren Etkin, founder of TheGerontechnologist.com.   Discussion includes the role of robots, implications for social interaction, as well as the additional opportunities for founders to take advantage of the coming geriatric storm.   01:04 Current Tech for Aging 05:17 Tech for Social-Emotional Support 09:03 The Driving Force Behind the Development 12:00 The Impact of Increasing Longevity 13:54 Affordability of Aging Tech 17:08 Cyborgification  

Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing  https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in the liver and absorbed exogenously from dietary sources. Endogenous Production: Cholesterol is synthesized in the liver through the mevalonate pathway. Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate. Exogenous Absorption: Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol. These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels. Section 2: Detailed Analysis of the Test Components Production Markers: Lathosterol: Precursor in the cholesterol biosynthesis pathway. Elevated levels indicate increased hepatic cholesterol synthesis (overproduction). Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production. Desmosterol: Another precursor in the synthesis pathway, contributing to total cholesterol production. High levels reinforce the diagnosis of increased cholesterol production. Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production. Absorption Markers: Beta-sitosterol: Plant sterol absorbed in the intestines, competes with cholesterol. High levels suggest increased absorption of dietary cholesterol. Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption. Campesterol: Similar to Beta-sitosterol, reflects cholesterol absorption efficiency. Elevated levels indicate increased absorption. Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor. Cholesterol Balance Score: Ratio of production to absorption markers. A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue. Example: Score of 2.4 suggests overproduction is the dominant issue. Section 3: Clinical Implications and Treatment Strategies (10 minutes) Frequency of Overproduction vs. Overabsorption: Common to see patients with either overproduction or overabsorption, but less commonly both. Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia. Overabsorbers: Often have high-cholesterol diets or genetic predispositions. Treatment Implications: Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis. Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective. Combination Therapy: Considered for mixed dyslipidemia cases. Case Examples: Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe. Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins. Section 4: Physiological Mechanisms and Genetic Considerations Pathophysiology of Cholesterol Production: Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance. Pathophysiology of Cholesterol Absorption: Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption. Section 5: Practical Application in Clinical Practice Incorporating the Test into Clinical Workflow: Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy. Tailor treatment based on whether a patient is an overproducer, an overabsorber, or both. Patient Communication: Explain test results in an understandable way, emphasizing personalized treatment plans.

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation.

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each.