Podcasts about Aging brain

Send us a textIn this episode of Causes or Cures, Dr. Eeks chats with Dr. Amir Baniassadi about how indoor temperature affects the aging brain.Dr. Baniassadi shares what we know so far about the relationship between temperature and cognitive function, and explores the theories behind how temperature might influence cognition as we age. He discusses the findings of his recent study on temperature and cognition, including what surprised his team most. He also touches on an earlier study he conducted on temperature and sleep, and offers practical tips for optimizing your home environment. Is there a “sweet spot” for room temperature that supports both clear thinking and better sleep?Dr. Baniassadi is an instructor of medicine at Harvard Medical School and a scientist at the Marcus Institute for Aging Research. His work focuses on the aging brain and how environmental factors affect health and well-being in older adults. He holds a PhD in Civil, Environmental, and Sustainable Engineering from Arizona State University and an undergraduate degree in Mechanical Engineering from the University of Tehran. He also completed postdoctoral training in Translational Research in Older Adults, as well as a fellowship at the Harvard Graduate School of Design.Learn more about his work here. You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

While growing older is inevitable, many of the troubles we associate with aging – including dementia, disability, and an increased dependence on others – are not. The choices we make now can help us to maintain our vitality, a sharp mind, and our independence as we age. Dr.Timothy Jennings will guide us as we learn how to maintain brain and body health throughout our lives. He will provide solid, up-to-date scientific research that not only prevents progression toward dementia, but will also reduce disability and depression and keep people living independently longer than those who do not practice these methods.Become a Parshall Partner: http://moodyradio.org/donateto/inthemarket/partnersSee omnystudio.com/listener for privacy information.

Can an aging senior with memory issues navigate the digital world?  I offer a solution.  A new client had an affair with a married man. Now her religious parents are furious, her lover is over the top mad she let her parents find out, his wife hates my client and has sunk into depression and this client wants to know what to do. My path forward is an outside the box approach that just might thread the needle. Have you ever seen a sentence with three cliches? In episode 127 I infuriated some political conservatives and country music fans and to make up for that unintended slight I wrote and recorded a song to show I do love country music and use it to sincerely apologize to them. My new song is called "We Thank God For Being an American" and I am very proud of it. In fact, I think I may have a hit on my hands. Please take a listen and let me know what you think. Subscribe and THRIVE!!!!

Your brain health is super important during menopause, so how can we sustain it? In this episode, Adele discusses the aging brain and how to keep it healthy for longer, learning how menopause impacts your cognitive health. A link to Adele's checklist: https://adelejohnstoncoaching.com/checklist-optin Download Adele's Journey Journal here : https://adelejohnstoncoaching.com/my-journey-journal/ Enquire about 121 coaching here : https://docs.google.com/forms/d/e/1FAIpQLSfw6vrmKPE7A1eYDKQJiR9No7ZDdpfq-grBdKYjZSR-vl0Qag/viewform For extra support: Support@adelejohnstoncoaching.com ____________ From your host : Adele Johnston I'm Adele Johnston, a certified nutritionist and positive psychology coach, passionate about helping women improve their menopause health and reclaim who you are without menopause taking over. This is a time in your life where you get to feel vibrant, sexy and reclaim you again! I'm proud to work with women like you and have created a very successful proven Reclaiming You 3 STEP PROCESS to help you take back control of your body during your menopause. For more details : https://adelejohnstoncoaching.com/ To get Adele's FREE 3-step Menopause Weight Loss Guide: https://adelejohnstoncoaching.com/menopause-weight-loss-guide/

In this episode of the Unreasonable Health Podcast, Cade Archibald kicks off The Ageless Brain five-part series, diving into the science of neuroinflammation, cognitive decline, and brain regeneration.He explores the role of peptides like Semax and Selank in reducing inflammation and enhancing neuroplasticity, alongside nootropics and lifestyle interventions that support brain health. Cade also introduces the NeuroCatch test, a cutting-edge tool for assessing cognitive function, and challenges listeners to engage in activities that boost neuroplasticity. Tune in to discover how to optimize your brain for longevity and peak performance!To optimize your brain, check us out! https://acueastwest.com/

Do psychiatric medications alter brain energy and metabolic health?Dr. Stephen Cunnane, a professor and researcher at the University of Sherbrooke, has been at the forefront of studying glucose and ketone metabolism in the aging brain, pioneering advanced imaging techniques to measure how the brain utilizes these critical energy sources with neurodegenerative conditions like Alzheimer's and Parkinson's.While glucose PET imaging has long been used to study brain energy metabolism, Dr. Cunnane's team was the first to develop ketone PET imaging, allowing researchers to look at the relationship between glucose and ketone metabolism in the brain and understand how ketones support brain function when it struggles to use glucose for energy.Now, Dr. Cunnane has turned his attention to metabolic psychiatry and is working on a new study looking at brain energy metabolism in individuals experiencing first-episode psychosis. This study will allow researchers insights into the metabolic state of the brain at the onset of major mental illness and how psychiatric medications influence brain energy use.In this episode, you will learn:How the brain uses fuel as we age – Why glucose metabolism declines over time and how ketones may compensate in aging and neurodegenerative conditions.The first ketone PET imaging studies – How Dr. Cunnane's team developed a method to directly measure ketone uptake in the brain and compare it to glucose metabolismPsychosis and brain energy metabolism – Examining glucose and ketone utilization in first-episode psychosis before and after antipsychotic treatment.Carbohydrate reduction in older adults – Findings from a study showing how moderate carb restriction improved metabolic and mental health in retirement home residents independent of weight loss.Parkinson's disease and ketones – Investigating how exercise, exogenous ketones, and carbohydrate restriction may enhance brain energy supply and improve symptoms.Dr. Cunnane has been a pioneer in the field of ketogenic therapy and brain energy. In addition to all the incredible work he is doing in the aging brain, we are excited to see his new research focusing on such critical components of metabolic psychiatry.Expert Featured:Dr. Stephen Cunnanehttps://recherche-cerveau-sherbrooke.ca/en/laboratory-team/Studies MentionedA reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE studyhttps://doi.org/10.1139/apnm-2024-0277Resources MentionedBrain Research Team Websitehttps://recherche-cerveau-sherbrooke.ca/en/Revolutionizing Assisted Living: Hal Cranmer's Ketogenic & Carnivore Approach to Senior Wellnesshttps://youtu.be/s86CFw0qhVc?feature=sharedFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources athttps://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

In this episode of HYDRATE, Tracy breaks down the real science of hydrogen water—how this tiny molecule fights inflammation, selectively zaps harmful radicals, and keeps your cells playing in harmony. She'll be answering your top Qs: bottles vs. tablets, why timing's critical (drink it FAST), and how to turn your water into a smart hydrator. Ready to thrive? Let's flow.

Send us a textAs the global population ages, brain health is becoming a critical focus.What we must all realize is the role that exercise plays in our ability to maintain and improve cognitive function as we age. Our ability to move and play might just be the number one factor in slowing down the brain's age.The latest research continues to show that various exercise strategies positively impact brain health and overall cognitive function.Today on Strong By Design, we welcome Dr. Cody Sipe from the Functional Aging Institute (FAI). Cody is the co-founder of FAI along with Dan Ritchie. Their mission is to educate health and fitness professionals about the aging population and how exercise is key in the longevity of their client base. FAI, established in 2013, also provides these health experts with an online platform and live events for continuous learning and growth opportunities.Host of this week's episode is coach Chris Wilson, who is very familiar with FAI, having both a Brain Health Trainer and Mastering Movement Disorders certification through FAI. Discover how to unlock your brain's full power by enhancing cognitive function through exercise!Cody Sipe has an extensive background in the fitness industry with 20 years of experience as a personal trainer, fitness instructor, program director, exercise physiologist and club owner. He is currently an Associate Professor and Director of Clinical Research in the physical therapy program at Harding University.  “More and more people are realizing how important power training for older adults is.” -Dr. Cody Sipe  Time Stamps00:47 - Welcome to the Strong By Design podcast! 01:10 - Meet today's special guest, Dr. Cody Sipe co-founder of Functional Aging Institute (FAI) 04:31 - Discover the factors that contribute to improving our cognitive function 08:09 - Dr. Cody shares the story of how FAI was founded 10:12 - Discussing the significant impact you can have on a person's life and well-being 17:30 - Strategies for attracting people with strong expertise 20:16 - What is power training? 24:54 - Why is it crucial to build healthy exercise habits early in life 31:58 - Physical job vs Desk job: Which one wins? 35:48 - Dr. Cody highlights success stories from his program 38:17 - What challenges does physical therapy face with older adults 40:00 - Why should we treat exercise like kids do as we age 44:20 - How to combine technology with brain and body training 48:23 - Older adults' greatest fear revealed 51:26 - Follow Dr. Cody to learn more about his work and FAI 52:31 - Please share and leave ratings & reviews for the SBD podcast Resources:·         FunctionalAgingInstitute.com Connect with Dr. Cody:·         Instagram·         Facebook·         YouTubeSupport the showConnect w/ CriticalBench: Youtube Facebook Instagram CriticalBench.com StrongByDesignPodcast.com

Patricia Faust is a gerontologist specializing in brain aging and brain health.She has a Master's in Gerontological Studies from Miami University in Oxford Ohio. Patricia is certified as a brain health coach and received a certification in Neuroscience and Wellness through Dr. Sarah McKay and the Neuroscience Academy. My Boomer Brain is the vehicle Patricia utilizes to teach, coach, and consult about brain aging, brain health, and living a brain-healthy lifestyle.  Her book, The Boomer Brain, educates boomers on strategies to live a brain-healthy lifestyle and prevent Alzheimer's and dementia.https://www.seniorcareauthority.com/resources/boomers-today/

Believe the hype—art can transform your life.In this episode of Flow Radio, hosts Steven Kotler, Dr. Michael Mannino, and Ryan Wickes explore the powerful connections between creativity, longevity, and the future of human-AI collaboration. Tune in for a fresh look at how an “aesthetic mindset” influences aging, cognitive health, and the amount of flow in your life. Plus, get the low down on how partnering with AI can boost your creative potential far beyond a run-of-the-mill brainstorm. This is a must-listen for anyone wanting practical tips to lead a happier, healthier, and more creative life.  Join the discussion by leaving your questions for future Afterthoughts episodes in the comments. In This Episode: 01:36 Art vs. Altruism 04:06 Creativity and Longevity 06:19 The Role of AI in Future Jobs  11:10 Wisdom and Creativity as We Age 17:32 Brain Damage and Creativity 28:27 Hacking Creativity with Daydreaming35:12 Microflow and Daily Art Practice 42:08 Can AI Be Truly Creative? About The Guest: Steven Kotler is a New York Times-bestselling author, an award-winning journalist, and the co-founder and executive director of the Flow Research Collective. He is one of the world's leading experts on human performance. He is the author of eleven bestsellers (out of fourteen books), including The Art of Impossible, The Future is Faster Than You Think, Stealing Fire, The Rise of Superman, Bold and Abundance. His work has been nominated for three Pulitzer Prizes, translated into over sixty languages, and has appeared in over 110 publications, including academic journals such as Neuroscience and Biobehavioral Reviews and Psychophysiology, and mainstream publications like The New York Times Magazine, Wired, Atlantic Monthly, Wall Street Journal, TIME, and the Harvard Business Review. Dr. Michael Mannino is the Director of Programs at the University of Miami's Institute for Data Science and Computing, focusing on AI projects across various domains. He holds a Ph.D. in neuroscience and a Master's in philosophy, with expertise in embodied cognition, critical thinking, and the philosophy of mind. As a professor of philosophy and ethics for over a decade, Michael integrates his academic background with a passion for peak performance, flow science, and the mind-body connection. He is also an athlete, musician, and avid learner, and serves on the Singularity University Miami Chapter. Episode Resources: Book: Your Brain on Art: How the Arts Transform Us by Susan Magsamen and Ivy Ross Book: The Mature Mind: The Positive Power of the Aging Brain by Gene Cohen Book: The Wisdom Paradox: How Your Mind Can Grow Stronger As Your Brain Grows Older by Elkhonon Goldberg Article: Eric Kandel's Research on Aesthetic Experience Podcast: John Kounios on Mood and Creativity  Flow Radio Is Presented By Flow Research Collective Flow Research Collective is a leading neuroscience research and training company. If you're interested in learning the science-backed techniques we used to train top executives at Facebook, Audi and even the Navy SEALs, click the link here: https://www.flowresearchcollective.com/zero-to-dangerous/overview⁠⁠ ‍ Follow Flow Research Collective: YouTube: ⁠https://www.youtube.com/@flowresearchcollective⁠ Instagram: ⁠https://www.instagram.com/flowresearchcollective⁠ LinkedIn: ⁠https://www.linkedin.com/company/flowresearchcollective⁠ X: ⁠https://twitter.com/thefrc_official⁠ Facebook: ⁠https://www.facebook.com/flowresearchcollective⁠ Spotify: ⁠https://open.spotify.com/show/6RQY0d5rdlEiinHEtfWy6A⁠ Website: ⁠https://www.flowresearchcollective.com⁠ ‍ Flow Research Collective was founded by Steven Kotler, one of the world's leading experts on human peak performance. He is an award-winning journalist and author with over ten bestselling books.

Send us a textIn today's podcast, we will meet Jerry Wiles, a choice servant of God who is making a significant contribution to the cause of Christ in encouraging Christians to age well for the sake of the Gospel. Listen well to his story, learn through his life challenges, and take notes on his wisdom about finishing well.Learn more about him at Jerry Wiles at Jerry Wiles — James Houston Center or Jerry Wiles - Speakers Bureau | Leadershipbooks.comEmail us: Hal@finishingwellministries.orgFollow us on Facebook: https://www.facebook.com/finishingwellministriesSupport Our Ministry: https://www.finishingwellministries.org/donateAre there biblical principles to help us understand how to finish well?Join Dr. Habecker LIVE on ZOOM for a greater understanding of the SEVEN Essentials to Finishing Life Well: https://www.finishingwellministries.org/upcoming-eventsThanks for listening as we all strive to live and finish life well!

As we age, our brains don't quite work as well as they used to... but thanks to new research from Stanford University we might be able to unwind the clock. On The Go's science columnist takes a look at how to rejuvenate the grey matter. (Krissy Holmes with Dr. Torah Kachur)

In this episode of Collective Insights, Dr. Greg Kelly hosts Dr. Heather Sandison, highlighting her profound impact on the field of dementia care and the launch of her new book, "Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health." Dr. Sandison shares insights from her extensive experience, covering topics like holistic interventions for the aging brain, the significance of personalized medicine, and her pioneering work at Marama, the innovative elder care facility she founded.Sponsored by Qualia Mind: qualialife.com/benangel Use code benangel when you shop Qualia Mind for 15% off your order. Get in touch. Instagram: https://www.instagram.com/qualialife. Facebook: https://www.facebook.com/qualialife. Email: support@qualialife.com.

Welcome to another enlightening episode of Next Steps 4 Seniors: Conversations on Aging! In this episode, your host Wendy Jones sits down with the esteemed Dr. Ana Daughtery, Assistant Professor and Director of the Aging Brain Study at Wayne State University, to demystify the aging brain and distinguish it from Alzheimer's Disease. In this episode, you'll discover: The Aging Brain vs. Alzheimer's: Learn the key differences between the natural aging process of the brain and the pathological changes seen in Alzheimer's Disease. What Improves with Age: Contrary to popular belief, some cognitive functions actually improve as we age. Dr. Daughtery highlights these positive aspects of brain aging. Identifying Decline: Understand the signs of cognitive decline and how to differentiate between normal aging and potential dementia-related conditions. Taking Action: Get practical advice on what steps to take if you suspect a loved one is experiencing a dementia-related decline. Hormones and Aging: Explore how menopause and hormonal changes impact brain health in women. The Aging Brain Study: Discover what the Aging Brain Study entails, how you can participate, and how to get more information about your own brain health. Don't miss this episode if you want to gain valuable insights into brain health as you age and understand the critical differences between normal aging and Alzheimer's Disease. Tune in for expert advice, practical tips, and empowering information to help you navigate the journey of aging with confidence. Episode Resources: Listen to Next Steps 4 Seniors: Conversations on Aging wherever you get your podcast or Website: NextSteps4Seniors and Conversations on Aging Conversations On Aging: Facebook and Instagram Questions, Comments, or Suggestions: 248.652.5010 or hello@nextsteps4seniors.com   Website: Healthy Aging Brain Laboratory Dr. Ana DaughertySee omnystudio.com/listener for privacy information.

In this episode of Next Steps 4 Seniors: Conversations on Aging, host Wendy Jones is joined by Dr. Ana Daugherty, Director of the Detroit Aging Brain Study (DABS) at Wayne State University's Cognitive Neuroscience of Aging Lab. Together, they explore the intricate journey of how our brains change as we age and what we can do to maintain cognitive health. Key Topics Covered: Research on the Aging Brain: Dr. Daugherty shares insights from her research on how aging affects memory and problem-solving skills. Motivators for Brain Health: Discover the key motivators for taking proactive steps to care for our brains. Typical Aging vs. Cognitive Decline: Understanding what normal aging looks like and how it differs from cognitive decline. Brain Development and Aging: A look into the process of brain development and the changes that occur as we age. Anatomy of the Brain: Exploring the structure of the brain and its functions. Impact of Education and Career Choices: How our educational and career paths influence brain health. Role of Hobbies and Activities: The importance of engaging in hobbies and activities for cognitive well-being. Cognitive Engagement: Why it is crucial to keep our minds actively engaged. Stress and the Aging Brain: The effects of stress on cognitive health and strategies to manage it. Mindfulness and Diet: How mindfulness activities and a healthy diet can positively impact brain aging. Metabolic Diseases and Brain Health: Why metabolic health is essential for maintaining cognitive function. Lifestyle Changes for Brain Health: Practical tips for lifestyle changes that support brain health. Exercise for Cognitive Health: The roles of anaerobic and aerobic exercise in keeping our brains and bodies healthy. Skeletal and Muscular Health: How maintaining physical health supports cognitive function. Join Wendy and Dr. Daugherty for a comprehensive discussion that sheds light on the aging brain and offers actionable strategies to keep your mind sharp and healthy. This episode is packed with valuable information for seniors and their families who are committed to aging well. Tune in now to learn how to nurture your brain health through every stage of life. Episode Resources: Listen to Next Steps 4 Seniors: Conversations on Aging wherever you get your podcast or Website: NextSteps4Seniors and Conversations on Aging Conversations On Aging: Facebook and Instagram Questions, Comments, or Suggestions: 248.652.5010 or hello@nextsteps4seniors.com   Website: Healthy Aging Brain Laboratory Dr. Ana DaughertySee omnystudio.com/listener for privacy information.

Aging may be on your mind this week. And it's an often overlooked aspect of planning for retirement. Coleen T. Murphy, a leading scholar of aging, and the author of How We Age: The Science of Longevity, details how recent research on model systems, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging, This research is helping us understand the fundamental biological rules that govern aging - and it may be bringing us closer to extending healthspans and slowing the effects of aging. She joins us here in Princeton, New Jersey. __________________________ Bio Coleen T. Murphy is professor of genomics and molecular biology at Princeton University. She is director of Princeton's Glenn Foundation for Research on Aging and director of the Simons Collaboration on Plasticity in the Aging Brain. She is director of the Paul F. Glenn Laboratories For Aging Research at Princeton. Murphy completed a B.S. with honors in biochemical and biophysical sciences at the University of Houston and earned a Ph.D. at Stanford University. She was awarded a graduate fellowship at Howard Hughes Medical Institute and completed her postdoctoral work at the University of California, San Francisco. ___________________________ For More on Coleen T. Murphy How We Age: The Science of Longevity ___________________________ Podcast Episodes You May Like Why We Remember – Charan Ranganath How Not to Age – Dr. Michael Greger The Mindful Body – Ellen Langer ___________________________ Wise Quotes On Why We Age "I think if the better question is why wouldn't we age? Like in the entire universe, entropy is at work. So things fall apart and unless you put in energy to repair them, those things will fall apart. So we're no different, but just we're better at repairing all of our cells and tissues and everything else when we're young, right? My kids, if they get a cut, it heals up in like two days. And if I do, it doesn't. So we see those repair processes decline with age. And so that's really why we age because the amount that our body's put into repair actually gets overwhelmed at some point." On Cognitive Aging "So, by studying processes that change with age, my lab is extremely interested in cognitive aging. So we want to make that extend as long as possible. Even if it didn't extend lifespan, if we found a mechanism to maintain your cognitive function as long as possible, that would be super valuable for all of us. And so, that's what we're talking about when we're talking about healthspan. A lot of these age -related diseases that we care about in humans and then we understand the molecular mechanisms so that we can find ways to extend that in humans as well...Can we actually extend the you know the time of normal cognitive function? And it turns out we've been able to uncover pathways that do control that. So I'm really excited about some work that we did where we you know we found some we found a genetic pathway where if we flipped on just one protein made it more active in one neuron of the cell. Admittedly they have hardly any neurons - they have only 302. But this particular neuron is one that's really important for regulating their memory and we turn that on a super old worm and it rescued their memory. Nobody really cares until you show it in a mouse. And so we collaborated with friends of ours at UCSF and they put in into the hippocampus so the brain of the two -year -old mice. So that's like a 75 to 80 year old person. They put in the same activated protein in these it. rescue their memory. So that shows that we can use these pathways to find something in worms and apply it to mammals. And by the way, that protein is exactly the same in mice and humans. So that gives us sort of a way into this problem where we could start to address it pharmaceutically. So that's an example. I don't think it's the only way.

BUFFALO, NY- June 12, 2024 – A new review paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, “Peripheral vascular dysfunction and the aging brain.” Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular diseases (CVD), which remain the leading cause of mortality worldwide. In their new review, researchers Devin Wahl and Zachary S. Clayton from Colorado State University and the University of Colorado note that robust evidence indicates that CVD are a strong determinant for reduced brain health and all-cause dementia with advancing age. “CVD are also closely linked with peripheral and cerebral vascular dysfunction, common contributors to the development and progression of all types of dementia, that are largely driven by excessive levels of oxidative stress (e.g., reactive oxygen species [ROS]).” Emerging evidence suggests that several fundamental aging mechanisms (e.g., “hallmarks” of aging), including chronic low-grade inflammation, mitochondrial dysfunction, cellular senescence and deregulated nutrient sensing contribute to excessive ROS production and are common to both peripheral and cerebral vascular dysfunction. Therefore, targeting these mechanisms to reduce ROS-related oxidative stress and improve peripheral and/or cerebral vascular function may be a promising strategy to reduce dementia risk with aging. Investigating how certain lifestyle strategies (e.g., aerobic exercise and diet modulation) and/or select pharmacological agents (natural and synthetic) intersect with aging “hallmarks” to promote peripheral and/or cerebral vascular health represent a viable option for reducing dementia risk with aging. “Therefore, the primary purpose of this review is to explore mechanistic links among peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. Such insight and assessments of non-invasive measures of peripheral and cerebral vascular health with aging might provide a new approach for assessing dementia risk in older adults.” DOI - https://doi.org/10.18632/aging.205877 Corresponding authors - Devin Wahl - devin.wahl@colostate.edu, and Zachary S. Clayton - zachary.clayton@colorado.edu Video short - https://www.youtube.com/watch?v=0gx9DklNZVM Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205877 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, peripheral vascular health, cerebrovascular health, cognitive function, dementia About Aging-US Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer's disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Pamela Jarrett tells us about research exploring ways to reduce the stress on our health system and help our aging population.

While Republican candidates in many states downplay their opposition to abortion, the most vehement wing of the movement, which helped overturn Roe v. Wade — those who advocate prosecuting patients, outlawing contraception, and banning IVF — are increasingly outspoken. Meanwhile, some state legislatures continue to advance new restrictions, like a proposal moving in Louisiana to include abortion medications mifepristone and misoprostol on the list of the most dangerous drugs. Alice Miranda Ollstein of Politico, Rachel Roubein of The Washington Post, and Joanne Kenen of the Johns Hopkins schools of public health and nursing and Politico Magazine join KFF Health News' Julie Rovner to discuss these stories and more. Also this week, Rovner interviews Shefali Luthra of The 19th about her new book on abortion in post-Roe America, “Undue Burden.” Plus, for “extra credit” the panelists suggest health policy stories they read this week that they think you should read, too: Julie Rovner: The 19th's “What Happens to Clinics After a State Bans Abortion? They Fight To Survive,” by Shefali Luthra and Chabeli Carrazana. Alice Miranda Ollstein: Stat's “How Doctors Are Pressuring Sickle Cell Patients Into Unwanted Sterilizations,” by Eric Boodman. Rachel Roubein: The Washington Post's “What Science Tells Us About Biden, Trump and Evaluating an Aging Brain,” by Joel Achenbach and Mark Johnson. Joanne Kenen: ProPublica's “Toxic Gaslighting: How 3M Executives Convinced a Scientist the Forever Chemicals She Found in Human Blood Were Safe,” by Sharon Lerner; and The Guardian's “Microplastics Found in Every Human Testicle in Study,” by Damian Carrington. Hosted on Acast. See acast.com/privacy for more information.

Coleen T. Murphy, Ph.D is Director, Lewis-Sigler Institute for Integrative Genomics,  James A. Elkins, Jr. Professor in the Life Sciences, Department of Molecular Biology, and LSI Genomics, Princeton University. She is also Director, Paul F. Glenn Center for Aging Research at Princeton and Director of Simons Collaboration on Plasticity and the Aging Brain. As a researcher, Coleen studies aging and the quantitation of “quality of life with age,” including the decline of cognitive and reproductive capacities with age. She is author of How We Age: The Science of Longevity. It is surprisingly readable and understandable. Coleen has had her own lab since 2005. She finds society's obsession with nutrition and dieting limiting for her research and has, instead, questioned what else can we do to preserve our health and cognitive aging. She has won numerous awards for her research including being named a Pew Scholar. Coleen was awarded the New Innovator, Transformative R01, and two Pioneer awards from the NIH Director's office. Effective research stems from knowing the right questions to ask. Coleen MurphyConnect with Coleen:Email: ctmurphy@princeton.eduPrinceton: http://www.molbio1.princeton.edu/labs/murphy/ ORCID: 0000-0002-8257-984XBook: How We Age: The Science of Longevity(AddLink)

We all know aging comes with cognitive challenges, but how early do they start? Sometimes, I forget my email password or where I put my car keys. Should I be worried? Dr. Nicole Byers came by to give us some fascinating answers, including the magical age when it can be beneficial to consume MORE calories. With a Ph.D. in clinical psychology and a dissertation focused on the aging brain, she's written extensively about brain health for Psychology Today. A neuropsychologist, TEDx speaker, and CEO of Rocky Mountain Neurosciences in Calgary, Canada, her passion is helping women in leadership rewire the unhelpful brain defaults that keep them stuck so they can take significant steps in their careers without getting in their own way or burning out. We all want to know how to keep our brains healthy for as long as possible. Who better to ask than someone who has dedicated her life to the topic? Stick around for some pearls of wisdom from Dr. Nicole Byers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode #199 In this week's episode, Terri returns to a topic that she brought up previously to share some more information that could be helpful for us all. She went back to learn more about neurobics after a reference to this topic during another episode. Here is your opportunity to quickly learn about some pretty simple ways to affect your neuronal health and growth. If you would like a quick reminder of some simple neurotic exercises you can do, this guide is a good starting point: https://www.ageuk.org.uk/bp-assets/globalassets/hertfordshire/documents/activities--events/neurobic-exercise-guide.pdf Please consider helping us make more episodes by supporting Daisy on Patreon. https://bit.ly/MondayMindsetPatreon If you have enjoyed listening to this episode, please leave us a review on iTunes or whichever platform you listen on. It really helps new people hear about the podcast. Connect with and follow us on Facebook, Instagram and YouTube: https://bit.ly/MondayMindsetFB https://bit.ly/MondayMindsetIG https://bit.ly/MondayMindsetYT

The standard story of old age is a period of cognitive decline. 86% of Americans seem to agree with this story. They think 81 year old President Biden is too old to serve another term as. And another 62% think the same of 77 year old Donald Trump. But is this standard story of the aging brain wrong? Do some of our cognitive capacities actually improve in old age? Do we actually become more cognitively and mentally capable of leadership as we grow older? The Agenda looks at the science of the aging brain.See omnystudio.com/listener for privacy information.

“A few years ago, I might have chuckled at the naiveté of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.”—Coleen MurphyTranscript with external linksEric Topol (00:06):Hello, this is Eric Topol from Ground Truths, and I'm just so delighted to have with me Professor Coleen Murphy, who has written this exceptional book, How We Age: The Science of Longevity. It is a phenomenal book and I'm very eager to discuss it with you, Coleen.Coleen Murphy (00:25):Thanks for having me on.Eric Topol (00:27):Oh yeah. Well, just so everyone who doesn't know Professor Murphy, she's at Princeton. She's the Richard Fisher Preceptor in Integrative Genomics, the Lewis-Sigler Institute for Integrative Genomics at Princeton, and director of the Paul Glenn Laboratories for Aging Research. Well, obviously you've been in this field for decades now, even though you're still very young. The classic paper that I can go back to would be in Nature 2003 with the DAF-16 and doubling the lifespan of C. elegans or better known as a roundworm. Would that be the first major entry you had?Coleen Murphy (01:17):Yeah, that was my postdoctoral work with Cynthia Kenyon.Eric Topol (01:20):Right, and you haven't stopped since you've been on a tear and you've put together a book which has a hundred pages of references in a small font. I don't know what the total number is, but it must be a thousand or something.Coleen Murphy (01:35):Actually, it's just under a thousand. That's right.Eric Topol (01:37):That's a good guess.Coleen Murphy (01:38):Good guess. Yeah.Eric Topol (01:39):So, because I too have a great interest in this area, I found just the resource that you've put together as extraordinary in terms of the science and all the work you've put together. What I was hoping to do today is to kind of take us through some of the real exciting pathways because there's a sentence in your book, which I thought was really kind of nailed it, and it actually is aligned with my sense. Obviously don't have the expertise by any means that you do here but it says, “A few years ago, I might have chuckled at the naivety of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.” That's a pretty strong statement for a person who's deep into the science. First I thought we'd explore healthy aging health span versus lifespan. Can you differentiate that as to your expectations?Coleen Murphy (02:54):So, I think most people would agree that they don't want to live necessary super long. What they really want to do is live a healthy life as long as they can. I think that a lot of people also have this fear that when we talk about extending lifespan, that we're ignoring that part. And I do want to assure everyone that the people in the researchers in the aging field are very much aware of this issue and have, especially in the past decade, I think put a real emphasis on this idea of quality of life and health span. What's reassuring is actually that many of the mechanisms that extend lifespan in all these model organisms also extend health span as well and so I don't think we're going to, they're not diametrically opposed, like we'll get to a healthier quality of life, I think in these efforts to extend lifespan as well.Eric Topol (03:50):Yeah, I think that's important that you're bringing that up, which is there's this overlap, like a Venn diagram where things that do help with longevity should help with health span, and we don't necessarily have to follow as you call them the immoralists, as far as living to 190 or whatever year. Now, one of the pathways that's been of course a big one for years and studied in multiple species has been caloric restriction. I wonder if you could talk to that and obviously there's now mimetics that could simulate that so you wouldn't have to go through some major dietary starvation, if you will. What are your thoughts on that pathway?Coleen Murphy (04:41):Yeah, actually I'm really glad you brought up mimetics because often the conversation starts and ends with you should eat less. I think that is a really hard thing for a lot of people to do. So just for the background, so dietary restriction or caloric restriction, the idea is that you would have to take in up to 30% less than your normal intake in order to start seeing results. When we've done this with laboratory animals of all kinds, this works from yeast all the way up through mice, actually primates, in fact, it does extend lifespan and in most metrics of health span the quality of life, it does improve that as well. On the other hand, I think psychologically it's really tough to not eat enough and I think that's a part that we kind of blindly ignore when we talk about this pathway.Coleen Murphy (05:30):And of course, if we gave any of those animals the choice of whether they want to start eating more, they would. So, it's like that's not the experiment we ever hear about. And so, the idea for studying this pathway isn't just to say, okay, this works and now we know how it works, but as you pointed out, mimetics, so can we target the molecules in the pathway so that we can help people achieve the benefits of caloric restriction without necessarily having to do the kind of awful part of restriction? I think that's really cool, and especially it might be very good for people who are undergoing certain, have certain diseases or have certain impairments that it might make it difficult ever to do dietary restrictions, so I think that's a really great thing that the field is kind of getting towards now.Eric Topol (06:15):And I think in fact, just today, it's every day there's something published now. Just today there was a University of Southern California study, a randomized study report comparing plant-based fasting-mimicking diet versus controlled diet, and showed that many metabolic features were improved quite substantially and projected that if you stayed on that diet, you'd gain two and a half years of healthy aging or that you would have, that's a bit of an extrapolation, but quite a bit of benefit. Now, what candidates would simulate caloric restriction? I mean, what kind of molecules would help us do that? And by the way, in the book you mentioned that the price to pay is that the brain slows down with caloric restrictions.Coleen Murphy (07:10):There's at least one study that shows that.Coleen Murphy (07:13):Yeah, so it's good to keep in mind. One of the big things that is being looked at as rapamycin, looking at that TOR pathway. So that's being explored as one of these really good mimetics. And of course, you have things that are analogs of that, so rapalogs, and so people are trying to develop drugs that mimic that, do the same kind of thing without probably some of the side effects that you might see with rapamycin. Metformin is another one, although it's interesting when you talk to people about metformin who work on it, it's argued about what is exactly the target of metformin. There's thought maybe also acts in the TOR pathway could affect complex one of mitochondria. Some of the things we know that they work, and we don't necessarily know how they work. And then of course there's new drugs all the time where people are trying to develop to other target, other molecules. So, we'll see, but I think that the idea of mimetics is actually really good, and that part of the field is moving forward pretty quickly. This diet that you did just mention, it is really encouraging that they don't have to take a drug if you don't want to. If you eat the right kind of diet, it could be very beneficial.Eric Topol (08:20):Yeah, no, it was interesting. I was looking at the methods in that USC paper and they sent them a box of stuff that they would eat for three cycles, multiple weeks per cycle. It was a very interesting report, we'll link to that. Before we leave the caloric restriction and these mTOR pathway, you noted in the book that there some ongoing trials like PEARL, I looked that up and they finished the trial, but they haven't reported it and it's not that large. And then there's the FAME trial with metformin. I guess we'll get a readout on these trials in the not-too-distant future. Right?Coleen Murphy (08:57):Yeah, that's the hope that especially with the Metformin trial, which I think is going to be really large the FAME trial, that just to give the listeners a little background, one of the efforts in the field is not just to show that something works, but also to convince the FDA that aging could be a pharmaceutical, a disease that we might want to have interventions for. And to do that, we need to figure out the right way to do it. We can't do 30-year studies of safety and things to make sure that something's good, but maybe there are reasonable biomarkers that would tell us whether people are going to live a long time. And so, if we can use some of those things or targeting age-related diseases where we can get a faster readout as well. Those are reasonable things that companies could do that would help us to really confirm or maybe rule out some of these pharmaceuticals as effective interventions. I think that would be really great for consumers to know, is this thing really going to do good or not? And we just don't have that right now in the field. We have a lot of people saying something will work and it might and the studies in the lab, but when we get to humans, we really need more clinical studies to really tell us that things are going to be effective.Eric Topol (10:12):Right, I'm going to get to that in a bit too because I think you're bringing up a critical topic since there's an explosion of biopharma companies in this space, billions of dollars that have been put up for in capital and the question is what's going to be the ground rules to get these potential candidate drugs to final commercial approval. But before I leave, caloric restriction and insulin signaling and the homolog and the human to what your discovery of DAF-16, FOXO and all this, I just want you to comment, it wasn't necessarily developed in the book, but as you know, the GLP-1 drugs have become just the biggest drug class in medical history, and they do have some effects here that are very interesting. They are being tested as in Alzheimer's disease. Do you see that this is a candidate too that might promote healthy aging?Coleen Murphy (11:12):Yeah, I'm so glad you brought that up because my book, I finished writing it right before all this stuff came out, and it's looking really very compelling. People are on these drugs, they lose a ton of weight, but their blood biomarkers really become very good and on top of just the changes in weight and those kinds of effects. Let me just say, I think the biggest thing, the biggest risk actually for aging people right now are cardiovascular problems, cardiovascular disease, and these drugs, no doubt, it's going to basically make a huge dent in that. I'm absolutely sure of that. What I also find really interesting with those drugs is that the users report that they have fewer cravings for other things. So, this is not being looked at to treat alcoholism and drug addiction, other things, so it really opens up a whole new world of things that are bad for us that maybe we could avoid this with these peptides. It's almost staggering. I really think this going to be a huge, and as far as an aging drug, if you reduce your weight, you improve all your cardiovascular function, you don't feel like drinking all the time, all these things might be really great and I do think that people will live longer.Eric Topol (12:32):Yeah, no, it does have that look and you just have to wonder if as these will go on to oral drugs with triple receptors and very potent, maybe even avoiding peptides in the future too, that this could wind up being something that's exceedingly common to take for reasons far removed from the initial indication of type two diabetes and more recently of course, obesity. Now the next topic I wanted to get into with you were senolytics, these agents that basically are thought to reverse aging or slow aging. And again, since everything's coming out in a daily basis, there was a trial in diabetes macular edema where giving senolytic after people had failed their usual VEGF treatment was highly successful. So, we're starting to see, at least in the eye results. I wonder if you could describe how you conceive this field of senolytics?Coleen Murphy (13:41):Actually, I think they've made great progress in the past couple of years because there were some initial failures, like some of the things for osteoarthritis that went through I think phase two, but I think that one of the great things about the longevity biotech field is that they're starting to identify not just longevity, these age-related disorders that they could actually use. And so, it's kind of doubly beneficial. It tells us that the drugs actually do something and so maybe it'll be used for something else in the future and you get through, you can test safety, but also helping people actually have a very real problem that's acute that they really need to take care of. And so that's really exciting. Then in addition to the example you just mentioned, I was at a conference last summer where it was being explored whether some of these senolytics could be helpful for middle aged survivors of childhood cancers who do show various health effects from having gone through chemotherapies at a young age. So that's really exciting. Could you help people who are not aging, but they actually are showing having problems that we kind of associate with aging. And senolytics were at least the first thing I'd heard about that are actually being used for that, so there may be other approaches that help as well, but I think that's really great.Eric Topol (15:05):Well, and just to be clear the senolytics, I guess could be categorized at least one function might be to help clear dead cells. These senescent cells are bad actors and either they're taken out or they're somehow neutralized in their impact of secreting evil humors, if you will. Are there other forms of senolytics besides that way of dealing with these senescent cells?Coleen Murphy (15:33):I know that some people are exploring senomorphs, so things that make those cells just arrest but I do want to mention, of course, we lost a great Judith Campisi recently, and she was the one who discovered and described the senescent associated secretory phenotype, and she did amazing work in that field really opening that up. So, this idea that bad cells aren't just bad because they don't function, but they're actually toxic to other cells.Coleen Murphy (16:04):That's important for listeners to know. Yeah, so I don't know. I think that one of the things I'm excited about in the aging field is that it doesn't seem like there's one magic bullet. A lot of researchers will spend their time working on that one thing so if you only talk to that one person, you might get that impression, but there's a whole host of things that for bad or good, that things go wrong when we age, but those all end up being maybe targets that could help us live longer or at least in a healthier way. And so, we've already talked about a couple of them, but readers will see as we learn more, there might be more ways to help cells survive or to help us replace ourselves, for example.Eric Topol (16:45):I mean, I think what you're bringing up here is central because there's all these different, as I can see it, shots on goal that of course could be even used as combinations, no less senolytic interventions so we're getting closer as we started this conversation to fulfilling what you, I think is in store in the years ahead, which is extraordinary. Along with the senolytics, I wonder if you could just talk a little bit about these autophagy enhancers as a class of agents, maybe first explaining autophagy and then is this a realistic goal that we should be taking autophagy enhancers, or is this something that's too generalized that might have onward mTOR effects?Coleen Murphy (17:39):Well, it's interesting. Autophagy, so just for the listeners, autophagy literally means self-eating. So this is a pathway whereby proteins basically get degraded within the cell and those parts get recycled. And the idea is that if you have a cell or protein that's damaged in some way, or it can be renewed if you induce autophagy. I think I could be wrong here, but my sense is that the cancer field is really excited about autophagy enhancers. And so, I think that's probably where we'll see the biggest breakthroughs but along the way, of course we'll know because we'll know if they're safe and if there's other off-target effects. I think that that's largely being driven by the cancer field and the longevity field is kind of a little bit behind that, so we'll learn from them. It seems like a really exciting approach as well.Eric Topol (18:34):Yeah, it does. And then as you know, the idea of giving young blood, young plasma, which there already are places that do this, that it can help people who are cognitively impaired and have basically immediate effects, and sometimes at least with some durability. It's very anecdotal, but this idea, we don't know what's in the young blood or young plasma to some extent. How do you process that?Coleen Murphy (19:10):Okay. Well, so what we do know, and this is really work that a lot of people like Saul Villeda and Tony Wyss-Coray have done where they really have, they've taken that blood or plasma and then found the parts in the plasma that actually do specific jobs. And so, we actually are starting to learn a lot about that and that's exciting because of course, we don't really want to give people young blood. What we really would like to do is find out is there a particular factor in the blood? And there seems to be many that could be beneficial. And so, we really are getting close. We as a field, and specifically like the research I just mentioned and that's exciting because you can imagine, for example, if there's one factor that's in blood, that's in young blood, that's very helpful, manufacturing, a lot of that particular thing.Coleen Murphy (20:01):The other exciting thing, again, this is Saul Villeda's lab that found that exercise mice. So even if they're the same age mice, if one of them is exercised, it makes factors that actually from the liver of the mouse upon exercise, that then gets secreted and then affect, improve cognitive function as well. So it seems like even within the blood, there's multiple different ways to get blood factors that are beneficial, whether they're from young blood or from exercise blood. And so, there's a lot of things we don't yet know, but I do think that field is moving very fast and they're identifying a lot of things. In fact, so I'm the director of Simons Collaboration Plasticity in the Aging Brain, and on that website we're developing basically a page that can tell you what are the factors and what has it been shown to be associated with, because we're very interested in slowing normal cognitive aging and blood factors seem to be one of the really powerful ways that might be available to us very soon to be able to improve that.Eric Topol (21:03):Yeah, no, I'm glad you mentioned that, Coleen. I think the point that you made regarding exercise, I certainly was struck by that because in the book, because we've known about this association with exercise and cognition, and this I think is certainly one potential link. An area that is also fascinating is epigenetics, so a colleague of mine here in the Mesa, Juan Carlos Belmonte, who was at Salk and left to go to Altos, one of these many companies that are trying to change the world in health span and lifespan. Anyway, he had published back several years ago.Coleen Murphy (21:53):Yeah, 2016.Eric Topol (21:54):Yeah, CRISPR basically modulation of the epigenome through editing and showed a number of through specific pathways, a number of pretty remarkable effects. I wonder if you could comment about epigenetics, and then I also want to get into this fascinating topic of transgenerational inheritance, which may be tied of course to that. So, what about this pathway? Is there something to it?Coleen Murphy (22:29):Well, absolutely. I just think we need to learn a lot more about it. So just for the listener, so epigenetics, we think about genetics that's basically based on DNA and chromosomes. And so, when we think about epigenetics, that could be either, we could be talking about modulation of the histone marks on the chromosomes that allow the genes to be expressed or be silenced. And then on the DNA itself, there are methylation marks. And so, people have used, of course, Steve developed a, sorry, I'm sorry. Steve Horvath developed a very nice, he was first to develop a DNA methylation clock. So this idea that you could, and that was really interesting because he based it on, he used this machine learning method to narrow down to the 353 marks that were actually predictive or correlated with age, but we don't understand how it biologically what that manifests in. I think that's not well understood. At the chromatin level, there's a lot of work on the specific histone marks that may change, for example, how genes are transcribed and so understanding that better will maybe help us understand what those changes. There's things called epigenetic drift, so genes stop being carefully regulated with age, and then how can we make that maintain better with age? It's one of the goals of the field in addition to basically understanding what's going on at the epigenetic level.Eric Topol (24:01):So now of course, could we alter that? Oh, it is fascinating as you say, that you could have the Horvath clock to so accurately predict a person's biological age. And by the way, just a few days ago, there was a review by all these clock aging folks in nature medicine about the lack of standards. There's so many clocks to basically determine biological age versus chronological age. Before we get into the transgenerational inheritance, what is your sense? Obviously, these are getting marketed now, and this field is got ahead of its skis, if you will, but what about these biologic age markers?Coleen Murphy (25:02):Yeah, I'm glad to hear that. I haven't seen that review. I should look it up. It's good to know that the players in the field are addressing those points. So just for the listeners, so these DNA methylation clocks so when Steve Horvath developed the first one, it was based on the controls from a very large number of cancer controls for other reasons, so he used a huge amount of information. It really depended on the, he was trying to develop a clock that was independent of which tissue, but it turned out there's more and more clocks that are tissue specific and really organism specific, species specific. It really depends on what you're looking at to make these, and whether you're looking at chronological age or trying to predict biological age. I think it's a little frustrating because what you'd really like to know as a consumer, if you send off for one of these clock kits, is it right?Coleen Murphy (25:57):What's the margin of error? If I took it every week, would I get the same number? And so, I think my sense is that people take it until they get a low number then, but you'd really like to know if they work, because if you want to take it, do a control and they start, get your clock number and then start taking some intervention and ask whether it works, right? Yeah. So, I think because the players in the field recognize these issues, they're going to straighten it out, but I think one part that drives a little bit of the problem is that we don't understand what that DNA methylation mark change translates into biologically. If we understood that better, I think we'd have a better feeling about it. Anne Brunet and Tony Wyss-Coray maybe a year and a half ago, they had a nice paper where two years ago where they looked at, they use a different type of clock, a transcriptional clock, and that worked really well. So they were looking at transcriptional clock in the subventricular zone, and they were able to actually see changes not just with age, but also when there was an intervention. I can't remember if they look at dietary restriction and then maybe an exercise in the mice. And so that's important for us to know how well those clocks work.Coleen Murphy (27:13):I think it'll get there. It'll get there.Eric Topol (27:15):You don't want to pay a few hundred dollars and then be told that you're 10 years older biologically than your chronologic age, especially if it's wrong. Right?Coleen Murphy (27:25):Yes. It'll get there. I think it may not be quite there yet.Eric Topol (27:30):And by the way, while we're on that, the organ clocks paper, in fact, just a recent weeks, I did interview Tony Wyss-Coray from Stanford, and we talked about what I consider really a seminal paper because using plasma proteins, they're able to basically clock each organ. And that seems like a promising approach, which could also help prove the case that you're changing something favorably with one of these various intervention classes or categories. Do you think that's true?Coleen Murphy (28:05):That feels more real directly looking at the proteins then.Eric Topol (28:08):Yeah, exactly. I thought that was really exciting work, and I'm actually going to visit with Tony in a few weeks to discuss it further. So excited about it.Coleen Murphy (28:18):That's great. He's doing great work, so it'll be a fascinating conversation.Eric Topol (28:21):Yeah, well this is also fascinating. Now, transgenerational inheritance is a very controversial topic in humans, which it is not so much in every other species. Can you explain why that is?Coleen Murphy (28:38):Well, there's a lot of, I would say emotional baggage attached here, right? Because that's what people are talking about, like transgenerational trauma. There's no doubt that traumatic experiences in childhood actually do seem to change the genome and change have very real biological effects. And that's been shown. So that's within the first generation. It's also no doubt that in other organisms, like in plants like DNA methylation, that's exactly how they regulate things, and that's multiple generations. So that's kind of the norm. And so, the question for humans is whether something like this, like a traumatic experience or starvation or thing, has an effect, not just on the person who's experiencing it, but also on their progeny, even on their grand progeny. And so, it's tough, right? Because the data that are out there are from pretty terrible experiences like the Dutch hunger winter. And so, there's a limited set of data, and some of those data look good, and some of them look weaker. Yeah, I think that we still need to figure out what's going on there, and if it's real, it'd be interesting to know. Are there ways, for example, with these epigenetic modulators, are there ways that you could help people be healthier by erasing some of those marks of trauma, generational trauma?Eric Topol (30:03):Yeah. So, I mean, the theory as you're getting to would be you could change the epigenome, whether it's through chromatin, acetylation, methylation, somehow through these experiences and it would be going through down through multiple generations. The reason I know it's controversial is when I reviewed Sid Mukherjee's book, the Gene, he had put in that it was real in humans, and the attack dogs came out all over the place. Now, we've covered a lot of these pathways. One that we haven't yet touched on is the gut microbiome, and the idea here, of course, it could be somewhat linked to the caloric restriction story, but it seems to be independent of that as well. That is there, our immunity is very much influenced by our gut microbiome. There's the gut brain axis and all sorts of interactions going on there, but what about the idea of using probiotics and particular bacterial species as a introducing the people as an idea in the future to promote health span?Coleen Murphy (31:18):Yeah, it's a great idea. So, I just want to back up and say the microbiome, the reason it's so fraught is because for a long time, people had confused correlation and causation. So, they would see that a person who has X disease has a difference in the microbiome from people who don't have that disease. And so, the question was always, do they have that disease because of a difference in the microbiome or the disease influence in the microbiome? And of course, even things that's eating different food. For example, if a child with autism doesn't want to eat certain range of food, it's going to have an effect on the microbiome. That does not mean the microbiome cause their autism. And so that's something where, and the same thing with Alzheimer's disease patients. I think that's often the source of some of this confusion. I think people wish that they could cure a lot of diseases by taking a probiotic.Coleen Murphy (32:09):On the other hand, now there's actually some really compelling data. Dario Valenzano's lab did a really nice experiment in killifish, which is my second favorite aging model research organism. So killifish, turquoise killifish, only live a few months. And so, you can do aging studies really quickly and what Dario's group did was they took the microbiome at middle aged fish, they wiped out their microbiome with antibiotics, and they added back either young or same age, and they saw a really nice extension of lifespan with the young microbiome. So that suggests, in that case where everything else is the same, it really does have a nice effect. John Cryan's group in Ireland did something similar with mice, and they showed that there was a beneficial effect on cognitive function in older mice. So those are two examples of studies where it really does seem like there is an effect, so it could be beneficial. And then there's of course things like microbiome transfer for people who are in the hospital who have had other things, because your microbiome also helps you prevent other diseases. Those being there, if you wipe out all of your microbiome, you can actually get infected with other things. It's actually a protective barrier. There's a lot of benefits, I think in order to, we don't know a ton about how to control it. We know there are these, it's gross, but fecal microbiome transplantation.Eric Topol (33:42):FMT. Yeah, yeah.Coleen Murphy (33:44):Exactly. And so, I think that is kind of the extreme, but it can be done. I think in appropriate cases it could be a very good strategy.Eric Topol (33:53):It's interesting. There was a study about resilience of the immune system, which showed that women have a significant advantage in that they have just the right balance of not having a hyper inflammatory reaction to whether it's a pathogen or other stimulus. And they also have, of course, an immunocompetent system to respond, so unlike men overall, that although the problem of course with more prone to autoimmunity because of having two x chromosomes and exist or whatever other factors. But also, there's a balance that there's an advantage, in the immune system as a target for health span and lifespan, a lot of things that we've talked about have some interaction with the immune system. Is there anything direct that we can do to promote a healthier immune system and avoid immunosenescence and inflammaging or immuno aging or whatever you want to call it?Coleen Murphy (35:04):Sure, I will admit that immunology is a field that I want to learn more about, but I do not know enough about it to give a really great answer. I think it's one of the things I kind of shied away from when I wrote the book that if I were to rewrite it, I would add a whole new section on it. I think that's a really booming field, this interaction between immunology and aging. Obviously, there's immune aging, but what does that really mean?Coleen Murphy (35:28):I feel like I can't give you a really intelligent answer about that. Even though I'd like to, and I don't know how much of it's because there's just sort of this general idea that the immune system stops functioning well, but I do feel like the immune system is actually so mysterious. I have a peanut allergy, for example. We don't even really, I mean, we can prime ourselves against that now. We can give kids little bits of peanuts, but all the things that I feel like immunology is the one that's probably taking off the most, and we'll probably in a decade know way more about it than we do now, but I can't give you a very smart answer right now.Eric Topol (36:09):Yeah, no, I do think it's really provocative and the fact that if you have these exhausting T cells that are basically your backup system of your immune system, if they're not working, that's not good. And maybe they can be revved up without being problematic. We'll see.Coleen Murphy (36:27):And I guess the real question is do we need to do something independent or is that folded into everything else? If you were giving someone a drug that seemed very good systemically or some of these blood factors, would you have to do something special just for the immune system or is that something that would also be effective? I feel like that would be good to know.Eric Topol (36:44):Now the other area that I want to bring up, which is a little more futuristic is genome editing. So recently when I spoke to David Liu, he mentioned, well, actually it was Jennifer Doudna who first put it out there, but we discussed the idea of changing the people like me who are APOE4 carriers to APOE2, which is associated with longer life and all these other good things. Why don't we just edit ourselves to do that? Is that a prospect that you think ever could be actualized?Coleen Murphy (37:20):Well, I was just at a talk by Britt Adamson just moments ago, and that field is moving really fast, right? All the work that David Liu has done, and it's really exciting, this idea that you can now cure sickle cell anemia.Coleen Murphy (37:35):Fascinating. And I think Jennifer Doudna rightly proposed early on that what we should really be hitting first are like blood. Blood's really good because it's not hitting the germline. It's really something where we can help people at that stage. I was thinking about that while Britt was talking, what are the things we'd really want to address with CRISPR? I'm not sure how high up in the list aging related factors would be compared to a lot of childhood diseases, things that are really debilitating, but certainly is true since when we're looking at APOE4. I think that's the one exception because that is so strongly correlated with healthy lifespan and Alzheimer's and things, so we really want to do something about that. The question is how would we do that? That's not a blood factor. I think we'd have to think hard about that, but it is on the list of looming on the horizon.Eric Topol (38:35):I wouldn't be surprised if someday, and David, of course thought it's realistic, but it's not, obviously in the short term. Well, this has been enthralling to go through all these possibilities. I guess when you put it all together, there's just so many ways that we might be able to, and one of the things that you also pointed out in your book, which something that should not be forgotten, is the fact that all these things could even worsen the inequities that we face today. That is you have any one of these click, if not multiple, it isn't like they're going to be available to all. And the problem we have now, especially in this country without universal health and access issues, could be markedly exacerbated as we're seeing with the GLP-1 drugs too, by the way.Coleen Murphy (39:27):Absolutely.Eric Topol (39:28):So, I just want to give you a chance to reinforce what you wrote in the book, because I think this is where a lot of times science leads and doesn't realize the practical implications of who would benefit.Coleen Murphy (39:42):Yeah, I think actually for aging research often, even when I first started doing this work back in 2000, the first thing people would ask me if they're below a certain age was, don't you think that's terrible? Make the rich people just live the longest? And they're not wrong about that. I think what it can, we should raise awareness about the fact that even these things that we consider simple, like doing caloric restriction or getting exercise, even those things are not that straightforward if you're working two jobs or if you don't have access to excellent foods in your neighborhood, right? Fruits and vegetables. If we really want to not just extend longevity but raise life expectancy, then we should be doing a lot more that's for improving the quality of life of many people. And so there is that idea. On the other hand, I do want to point out that as we discover more and more of these things, like metformin is off patent, it's like it's really old. And so, it's more of these things get discovered and more broadly used. I do think that that may be a case where we could end up having more people might have access to things more easily. So that's my hope.Coleen Murphy (40:57):I don't want to discourage anyone from developing a longevity dry. I think eventually that could help a lot of people if it's not too absurdly expensive.Eric Topol (41:04):Yeah, no, I certainly agree. And one last footnote is that we did a study called The Wellderly here, about 1,400 people over age 85 who'd never been sick, so our goal here wasn't lifespan. It was to understand if there was genomics, which we did whole genome sequencing of this group. We didn't find much like the study that you cited in the book by the Calico group. And so just to give hope that people, if they don't have what they think are family genetics of short life or short health span, that may not be as much to that as a lot of people think. Any final thoughts about that point? Because it's one that's out there and data goes in different directions.Coleen Murphy (41:55):Yeah. The Calico study you mentioned, I think that's the one where they found that your health or lifespan mostly went with almost like your in-laws, which actually points again to your socioeconomic group probably you marry people, most people marry people are in a similar socioeconomic group. That's probably what that mostly had to do with. I do think if I'm going to say one thing because a lot of these drugs are on the horizon, they're not yet available, or there's nothing I can hang onto for an FDA approved drug to extend that. I do think the one thing that I would encourage people to do even more than the dietary restriction stuff, it is exercise because that's just generally beneficial in so many different ways. And so, if we can get people doing a little more exercise, I think that would be the one thing that probably could help a lot of people.Eric Topol (42:40):Well, I'm glad we are winding up with that because I think the data from lifestyle, which is exercise as you're pointing out, as well as nutrition and sleep.Coleen Murphy (42:54):All the boring things we already thought, right.Eric Topol (42:55):That we know about, but we don't necessarily put in our daily lives. There's a lot there. There's no question that studies, I think, really have reinforced that even recent one. Well, what a pleasure to talk to you about this and do this tour of the various exciting prospects. I hope I haven't missed anything. I know we can't go over all the pathways, and obviously there've been some bust in the past, which we don't need to review like the famous Resveratrol Sirtuin story, which you addressed in the book. I do want to encourage people that this book is extraordinary. Your work that you put into it had to be consumptive for I don't know how many years of work.Coleen Murphy (43:37):There was many years of work. My editor, we sat down to lunch right after it finished. She was like, so what are you going to work on for your next book?Eric Topol (43:50):Well, it's a scholarly approach to a very important field. If you can influence the aging process, you influence every part of our body function. The impact here is profound, and the contribution that you've made in your science as well as in your writing here is just so terrific. So thank you, Coleen. Thanks so much for joining us today.Coleen Murphy (44:17):Thank you so much. It's been a pleasure.Thanks for listening and/or reading this edition of Ground Truths, aimed at bringing you cutting-edge biomedical advances via analyses and podcasts.All content is free. Voluntary paid subscriptions go to support Scripps Research and have funded our summer intern program. Get full access to Ground Truths at erictopol.substack.com/subscribe

If Joe Biden and Donald Trump are on the ballot in November, they'll be the oldest presidential candidates in U.S. history. How does age affect our memory, cognition, and even the ability to be president? About: On Point is WBUR's award-winning, daily public radio show and podcast. Every weekday, host Meghna Chakrabarti leads provocative conversations that help make sense of the world.

Dave and Jason discuss the known details of the tragic mass shooting in Kansas City, Missouri at the Superbowl Celebration before discussing the honest and dishonest discourse surrounding Joe Biden and his mental acuity in his advanced years. They then talk "Lethal Weapon" and give their long-awaited thoughts on The Rock, Cody Rhodes, Roman Reigns and Wrestlemania XL.Please help Ed Gometz and his family battle leukemia at this link: https://www.gofundme.com/f/help-dr-ed

About Guy Odishaw Guy Odishaw is the founder of Bhakti Wellness Center, one of the largest, most diverse, integrative medicine clinics in the country. Co-founder of the first integrative student health clinics in the country at the University of Minnesota. Cofounder of Bhakti Brain Health Clinic - Neuroimaging & Neuromodulation. Cofounder of Minnesota Bredesen Clinic - Dementia Prevention & Treatment Co-founder of CerebralFit Brain Training, a Nutraceutical, Electroceutical, company. Guy's 30 years of clinical experience specializing in treatment resistant chronic pain, traumatic brain injury and psycho-emotional trauma informs his approach to brain health. Additionally, his 20+ years as meditation instructor and facilitator of courses on personal growth helped him understand how to support clients through the potent changes arising from Neurotherapy. Brain training does not only alleviate unwanted symptoms it often also positively changes one's whole sense of self and relationship to the world around them.   What We Discuss In This Episode In this episode, we talk about Guy's favorite subject – the treatment and prevention for neurodegenerative diseases, for example, dementia, Parkinson's, macular degeneration. With his general area of expertise being in Bioelectric Medicine and brain health, he remarks that although it's about brain healthy, they treat the whole body. The Aging Brain and anxiety. Cracking the longevity code & living better & longer with regenerative medicine Dementia unraveled -  effective strategies for treatment & prevention Shedding light on healing: the science and benefits of infrared light therapy Sparking Brain Health: Exploring the Power of Bioelectric Medicine, Neuromodulation, & Microcurrent Therapy   Free Resource from Guy Odishaw Free 15 min consult: https://www.cerebralfit.com   Connect With Guy Odishaw Website: https://www.cerebralfit.com Facebook: https://www.facebook.com/cerebralfit Instagram: https://www.instagram.com/cerebralfit/ LinkedIn: https://www.linkedin.com/in/guyodishaw/   Connect with Lynne: If you're looking for a community of like-minded women on a journey - just like you are - to improved health and wellness, overall balance, and increased confidence, check out Lynne's private community in The Energized Healthy Women's Club. It's a supportive and collaborative community where the women in this group share tips and solutions for a healthy and holistic lifestyle. (Discussions include things like weight management, eliminating belly bloat, balancing hormones, wrangling sugar gremlins,  overcoming fatigue, recipes, strategies, perimenopause & menopause, and much more ... so women can feel energized, healthy, and lighter, with a new sense of purpose. Website:  https://holistic-healthandwellness.com Facebook: https://www.facebook.com/holistichealthandwellnessllc The Energized Healthy Women's Club:  https://www.facebook.com/groups/energized.healthy.women Instagram: https://www.instagram.com/lynnewadsworth LinkedIn:  https://www.linkedin.com/in/lynnewadsworth   Free Resources from Lynne Wadsworth: How to Thrive in Menopause:   MENOPAUSE Messing Up your life?  Maybe you're seeing the number on the scale creep higher and higher and you're noticing your usual efforts to lose weight aren't working. Then there's the hot blazes, night sweats, and sleeping fitfully, not to mention that you're fighting tears one moment, raging the next, and then, the shameful guilt sets in because you've just blasted your partner – for nothing…again! Learn how to successfully and holistically navigate perimenopause and full-blown menopause, and even reconcile all the hormonal changes and challenges that go along with it. You'll be feeling energized, healthier, and more in control so you can take on your day confidently and live life joyfully – even in menopause. I've got this FREE solution tool for you.  Download my guide here: https://holistic-healthandwellness.com/thrive-through-menopause/   Grab Your Opportunity For a Free Call with Lynne: Would you love to be successful focusing on improved health & wellbeing in 2024?  Maybe you'd like to increase your energy levels, reduce or maintain a healthy weight, ditch the brain fog & belly bloat. Or maybe you'd love some more strategies to help transform you into a “magnificent midlifer” who's fully energized - charged & ready to start each new day with anticipation and & joy, Or maybe you have some illness you've been facing and it's compounded by menopause. I'd love to chat.  Contact me to schedule your FREE HEALTHY YOU Clarity Call. We'll discuss where you're at on your journey and how I can help you successfully navigate your life through this "midlife season" with grace and ease.  Schedule your time >>here

In this episode we address the complexities of aging memory, Alzheimer's, and the latest in treatment advancements. The discussion kicks off with an exploration of memory changes associated with normal aging, distinguishing these from Alzheimer's disease. We discuss the impact of lifestyle factors like alcohol, sleep, and new medications on memory preservation and Alzheimer's risk. There are subtle differences in memory loss experienced in normal aging, such as forgetfulness and word-finding difficulties, and the more severe and rapid forgetting characteristic of Alzheimer's disease due to brain damage. This segment is a must-listen for anyone interested in understanding the nuances of memory changes as we age.Educated at Haverford College and Harvard Medical School, Dr. Andrew Budson is Chief of Cognitive Behavioral Neurology at the VA Boston Healthcare System, Associate Director of the Boston University Alzheimer's Disease Research Center, Professor of Neurology at Boston University, and Lecturer in Neurology at Harvard Medical School. He has written 9 books, including his latest, Seven Steps to Managing Your Aging Memory—now in its 2nd edition—which explains how to distinguish changes in memory due to Alzheimer's versus normal aging, what medications, diets, and exercise regimes can help, and the best habits, strategies, and memory aids to keep your memory strong.Connect with Dr. Budson here:https://www.andrewbudsonmd.com/https://www.linkedin.com/in/andrew-budson-054a346b/To learn more, visit:www.servingstrong.comListen to more episodes on Mission Matters:www.missionmatters.com/author/scott-couchenourPractice Partnership: Monetizing Your Dental PracticeDoctors – are you interested in building long-term wealth and continuing on as an...Listen on: Apple Podcasts Spotify

As researchers continue their search for the fountain of youth, they're turning their attention to an unlikely source: worms. Coleen T. Murphy is professor of genomics and molecular biology at Princeton and director of both the university's Glenn Foundation for Research on Aging and the Simons Collaboration on Plasticity in the Aging Brain. She joins host Krys Boyd to discuss how worms and other simple organisms offer insights into the aging process and how we might slow it down. Her book is “How We Age: The Science of Longevity.”

CranioSacral Therapy -The Missing Piece To Alzheimer's Care Discover a groundbreaking approach to Alzheimer's care in this enlightening talk by Michael Morgan LMT, CSTD. Drawing on his extensive experience in CranioSacral Therapy, Morgan reveals the crucial role of fascia in brain health and offers a promising new perspective on the treatment of Alzheimer's. Dive into fascinating discussions on fascia, stem cells, and practical home therapies designed to improve brain health. #AlzheimersCare #CranioSacralTherapy #brainhealth Disclaimer:Medical and Health information changes constantly. Therefore, the information provided in this podcast should not be considered current, complete, or exhaustive. Reliance on any information provided in this podcast is solely at your own risk. The Real Truth About Health does not recommend or endorse any specific tests, products, procedures, or opinions referenced in the following podcasts, nor does it exercise any authority or editorial control over that material. The Real Truth About Health provides a forum for discussion of public health issues. The views and opinions of our panelists do not necessarily reflect those of The Real Truth About Health and are provided by those panelists in their individual capacities. The Real Truth About Health has not reviewed or evaluated those statements or claims. 

We all know the physical benefits of exercise, but today we talk about the brain benefits. How does exercise impact depression and anxiety? How can exercise help keep our brains young? Should our exercise habits change depending on our mental health? Today, we speak to Dr. Jennifer Heisz, Professor of Kinesiology at McMaster University. Check out her book Move the Body, Heal the Mind. To get weekly episodes, come join the Foodie Fam: https://www.patreon.com/FWNTT Check out our book! https://read.macmillan.com/lp/food-we-need-to-talk/ Chat with us on IG! https://www.instagram.com/foodweneedtotalk/?hl=en Be friends with Juna on IG and Tiktok! https://www.instagram.com/theofficialjuna/ https://www.tiktok.com/@junagjata

Welcome to Real Food Recovery, a podcast created by two lifelong processed food addicts with over 100 years of addiction (and recovery) between them. Paige Alexander and Jamie Morgan Reno use their Real Food Recovery podcast and social media channels to share their struggles, lessons learned, tools, tips and resources that freed them from decades of food addiction, obsession, and loss.   In Episode 20, Paige and Jamie cover nutrition's impact on the aging brain. They share what we can do to protect ourselves from Alzheimer's or dementia. You might be surprised to learn the impact processed food has on accelerating aging and all its associated illnesses. Jamie and Paige remind us that we are our own genetic engineers, creating our destinies with each bite we take. Give your body and brain the “comfort”  foods they know how to use and watch what happens. And, listen to the end to find out the exact age we need to start making these changes to prevent diseases of aging. This episode is chock full of science and facts, but we promise it's worth a listen.   In every Real Food Recovery episode, Paige and Jamie take time to answer viewer questions about processed food addiction, obsession, and recovery, be sure to submit yours on their YouTube Channel or Facebook Page. You can also follow Real Food Recovery on Instagram (@realfoodrecovery4u) and TikTok (@realfoodrecovery).  And, check out our website at www.realfoodrecovery4u.com!   

Dr. “So Good” SherwoodWEBSITE: http://doctorsogood.com-------------------------------------------TO WATCH ALL FLYOVER CLIPS -https://banned.video/playlist/622553248186d152c5d07f5dSPONSORS FOR TODAY'S VIDEO► ReAwaken America- text the word EVENTS to 40509(Message and data rates may apply. Terms/privacy: 40509-info.com)► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover► Z-Stack - https://flyoverhealth.com ► Dr. Jason Dean (BraveTV) - https://parakiller.com Want to help spread the Wake Up • Speak Up • Show Up -https://shop.flyoverconservatives.com/-------------------------------------------Follow our Social Media so we can be best friends

Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS -https://banned.video/playlist/61e636f26959067dbbfa11bfTO WATCH ALL FLYOVER CONTENT: theflyoverapp.comBo Polny WESBITE: https://bopolny.com/WEBSITE: www.Gold2020forecast.com For Bo Polny's Slides - text the word BO to 40509(Message and data rates may apply. Terms/privacy: 40509-info.com)To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com Or Call 720-605-3900 Dr. “So Good” SherwoodWEBSITE: http://doctorsogood.comSPONSORS FOR TODAY'S VIDEO► ReAwaken America- text the word EVENTS to 40509(Message and data rates may apply. Terms/privacy: 40509-info.com)► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover► Z-Stack - https://flyoverhealth.com ► Dr. Jason Dean (BraveTV) - https://parakiller.com Want to help spread the Wake Up • Speak Up • Show Up -https://shop.flyoverconservatives.com/-------------------------------------------Follow our Social Media so we can be best friends

Today we take a deep dive into some superfoods and learn about which colors of the rainbow are best for supporting a clear mind and sharp memory with Dr. Evie Kemp. And what's good for the brain is also good for the heart, so we also cover how some of the benefits eating foods with a certain color can help our cardiovascular health too. Dr. Kemp worked for many years as lead physician in occupational medicine at the Centre for Occupational Health and Wellbeing at John Radcliffe Hospital in Oxford, in the United Kingdom. She has a special interest in doctors' and medical students' health and wellbeing and many of her patients came from these two groups. Since 2018 Dr. Evie has divided her time between Israel and Oxford and is now working in medical education; running workshops for doctors, lecturing medical students and is the Director of Medical Student Wellbeing at the Technion American Medical School in Haifa. Dr. Evie is also the founder of Haskapa which produces superfood products made from the haskap berries grown on their all-natural farm in Nova Scotia, Canada. As research director she coordinates haskap berry scientific knowledge and academic research for the company. Disclaimer: This podcast represents the opinions of Dr. Evie Kemp, Haskapa Research Director. The content should not be taken as medical advice and is for informational purposes only. Please consult your healthcare professional for any personal medical queries. Use discount code ZORA for 15% off at haskapa.com Contact Dr. Evie Email: evie@haskapa.com or hello@haskapa.com Facebook: https://en-gb.facebook.com/haskapa/ Twitter: https://twitter.com/haskapa Instagram: https://www.instagram.com/haskapa/ Join the Hack My Age community on: Facebook Page : http://facebook.com/hackmyage Facebook Group: Biohacking Women 50+ - Longevity After Menopause https://www.facebook.com/groups/biohackingwomen50 Instagram: http://instagram.com/hackmyage Website: http://www.hackmyage.com Clubhouse: @hackmyage (Club: Biohacking Women 50+) Hack My Age VIP Group: http://patreon.com/hackmyage Email: zora@hackmyage.com Newsletter: http://www.hackmyage.com/newsletter This podcast is edited by jonathanjk.com --- Send in a voice message: https://anchor.fm/hackmyage/message Support this podcast: https://anchor.fm/hackmyage/support

Today's guest brings a mindful approach to coaching adult children of aging parents. For years, Maggie Miller was an Executive Coach and has seen the kinds of things that you might be dealing with. She can help you take your jumbled ideas and make them actionable, stand beside you and support you and share resources and ideas - and how you can put them to work to help you help those you love.When you begin caring ABOUT an aging parent, and not necessarily FOR them (listen to Maggie describe the difference) you step into a job you didn't apply for! That's where having a Coach can be a life saver, for all involved. I called Maggie when I needed help. She shared resources and support that enabled me to step out of fear and into understanding.3 Takeaways from our conversation:1. Fear of the unknown can be alleviated by knowing what resources are available.2. Always a have a few Starbucks gift cards on hand to give to folks you meet along the way who are helpful - a small thank you! (I keep a few in my wallet)3. A list of questions you brainstorm ahead of time to ask helpers or navigate with parents, can smooth out a challenging conversation. Books Maggie recommends (please copy and paste book titles in and use my new support small book sellers link to buy and let me know if it works! I'll try and make it easier as I figure it out, too)  https://bookshop.org/shop/mindfullconversations1. The Mature Mind and The Power of the Aging Brain by Dr. Gene Cohen2. The Song of Our Scars by Haider WarraichYou can find Maggie at https://www.maggiemiller.org/coach-adultchildren-agingparents Follow my blog (the inspiration for this podcast) https://themindfullcreative.comDM me on Instagram and let me know what you think! https://www.instagram.com/mindfullconversations/

In this conversation, Daniel Belkin and Mitch Belkin interview Jean Hébert, PhD about aging, brain plasticity, and progressive neocortical replacement. They discuss one hallmark of aging—extracellular matrix damage—as well as how tissue replacement is a possible solution to aging. In addition, they explore the practicalities of progressive neocortex replacement, dopaminergic neuron transplants in Parkinson's patients, and Professor Hébert's work on stroke.Who is Jean Hébert?Jean Hebert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine where he focuses on age-related brain degeneration in the adult neocortex. He is one of the world's leading researchers on brain cell and tissue replacement. He is the author of the book Replacing Aging.Follow us at @ExMedPod Subscribe to our Youtube channelConsider supporting us on Patreon

In this series, we're taking a look at some of the real science, policy, economics, law and ethics that inspired the events of Vanguard Estates. Today: what even is dementia, and why can't we cure it?   Guests: Dr. Malú Gámez Tansey — professor of neuroscience and neurology at the University of Florida, and the co-director of the Center for Translational Research in Neurodegenerative Disease Dr. Tia Powell — psychiatrist and the director of the Center for Bioethics at Albert Einstein College of Medicine, author of the book Dementia Reimagined: Building a Life of Joy and Dignity from Beginning to End. Charles Piller — investigative reporter at Science magazine Dr. Tanisha Hill-Jarrett — neuropsychologist and postdoctoral fellow at UCSF Dr. Margot Kushel — professor of medicine at UCSF and the director of the Center for Vulnerable Populations and the Benioff Homelessness and Housing Initiative Kate Swaffer: activist & author, co-founder of Dementia Alliance International Nikki: care partner & founder of A Log Cabin in Brooklyn → → → Further reading & resources here! ← ← ←  Flash Forward is hosted by, Rose Eveleth and produced by Ozzy Llinas Goodman. The intro music is by Asura and the outro music is by Hussalonia. The episode art is by Mattie Lubchansky. Get in touch:  Twitter // Facebook // Reddit // info@flashforwardpod.com Support the show: Patreon // Donorbox Subscribe: iTunes // Soundcloud // Spotify  Episode Sponsors: Purple Carrot: Purple Carrot is THE plant-based subscription meal kit that makes it easy to cook irresistible meals to fuel your body. Each week, choose from an expansive and delicious menu of dinners, lunches, breakfasts, and snacks! Get $30 off your first box by going to www.purplecarrot.com and entering code FLASH at checkout today! Purple Carrot, the easiest way to eat more plants!  Knowable: Learn today's most in-demand skills with actionable, podcast-style lessons from top experts. Download the Knowable app or visit Knowable.fyi and use the code FLASHFORWARD for an additional 20% off.  The proceeds from ads on this episode will be donated to Moms 4 Housing. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Greg Petsko is the Arthur J. Mahon Professor of Neurology and Neuroscience and Director of the Helen and Robert Appel Alzheimer's Disease Research Institute at Weill Cornell Medical College, as well as the Tauber Professor of Biochemistry and Chemistry, Emeritus, at Brandeis University. Greg is a structural biologist and biochemist by training, but he has entered into a new research field where he is working to find cures for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and Lou Gehrig's disease. When he's not working, writing about science and society is something Greg enjoys and is passionate about. He received his PhD from the University of Oxford and worked at Wayne State University, MIT, and Brandeis University before joining the faculty at Cornell where he is today. He has received numerous awards and honors during his career, including the Pfizer Award in Enzyme Chemistry of the American Chemical Society and the Max Planck Prize. Greg is also a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is the Past-President of the American Society for Biochemistry and Molecular Biology and is President of the International Union of Biochemistry and Molecular Biology. He has also written a column on science and society that is available as a book entitled Gregory Petsko in Genome Biology: the first 10 years. In our interview, Greg shares stories from his life and science.

Episode 222  Clutter is a problem many people face in their homes and offices. We have many things we don't use, so we get a lot of clutter. When we are constantly surrounded by clutter, it becomes difficult to focus on what's important. Decluttering helps us simplify our lives and make space for what matters. So how do you start decluttering?  Join the conversation as I interview organizing expert Tracy McCubbin.  Tracy is the CEO of dClutterfly, a Los Angeles premiere organizing and decluttering company, and the author of the books; Making Space, Clutter Free, and Make Space for Happiness: Tracy shares how she developed a decluttering mindset and how she started her decluttering company. She also talks about the importance of decluttering your home before you die and gives tips on how you can start the decluttering process. Click here to read this episode's full show notes.   Thank you for listening! I appreciate you.    Want to stay in touch? Join Lori's email community to receive inspiration and tips on how to find joy + confidence living alcohol-free later in life. Click here to join the mailing list.  

David Shuster hosts. Author Daniel Gross joins to talk about his latest book that covers the life of Edmond J Safra. Insider Policy and Politics Correspondent Kimberly Leonard discusses how aging affects the brain, specifically politicians and presidents. Hosted on Acast. See acast.com/privacy for more information.

Can eating specific foods help with brain health? The latest research says yes.    A new study found that following the MIND diet—a combination of the Mediterranean diet and the DASH diet—can help reduce our risk of Alzheimer's disease and dementia. In this episode, we'll hear from an expert on aging about how to keep our brain healthy.   Today I'm joined by Dr. Quinn Kennedy, Director of Aging Research at neuroFit. She earned a PhD in Psychology and completed postdoctoral training in Cognitive Aging, both at Stanford University. Her latest project is an online webinar series that illustrates why cognitive boosting activities should be incorporated into your retirement plan.   Tune in to learn more about: What new research says about the best diet for your brain One of the best things you can for your eating habits A surprising finding about drinking one daily glass of wine Which food nutrients we need to eat more of after turning 60 How our daily calorie need decreases with age   Connect with Quinn Stanford Continuing Studies workshop Maintaining Brain Health is Good for Your Wallet webinar series Free diet and nutrition resources  neuroFit

We talk quite a bit about exercising your physical body but what about exercising your brain? How much time do you devote each day to keeping your mind sharp? In this episode, we discuss 6 ways you can exercise your brain to keep you healthy well into your later years.  

The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Show notes and video CHAPTERS: 06:04 - Introduction 08:12 - Atherosclerosis 13:49 - Brain 16:07 - Circulating LPS and behavior 19:05 - Toll-like receptors and inflammation 24:00 - Factors that affect intestinal permeability 30:10 - Alcohol 32:07 - Gluten 35:21 - Butyrate and dietary fiber 37:48 - Dietary fat 42:21 - Biomarkers of intestinal permeability 43:11 - Omega-3 fatty acids 50:02 - Q&A LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier Learn about intestinal permeability Learn about toll-like receptors Learn about cerebral small vessel disease SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of the FoundMyFitness platform. Become a member