Podcasts about senolytics

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Zombie cells, scientifically known as senescent cells, are damaged or aged cells that refuse to die when they should. Instead, they linger in the body, releasing harmful chemicals that can trigger inflammation and accelerate aging. These cells have been linked to a range of age-related diseases, including arthritis, Alzheimer’s, and even cancer. Dive into the eerie world of 'Zombie Cells' on our latest episode! Uncover how these undead cells wreak havoc in our bodies and what cutting-edge research reveals about their role in aging and disease. Today on The Lab Report: 4:15 Cell turnover, apoptosis, and autophagy vs. zombie cells 7:30 What triggers zombie cells to form and what are telomeres? 10:15 Age-related diseases and inflammation 12:15 Senolytics and strategies to clear zombie cells 17:30 Just practice naturopathic medicine 18:30 Rules to survive a zombie apocalypse Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

BUFFALO, NY — April 1, 2025 — A new #research paper was #published in Aging (Aging-US) on March 29, 2025, as the #cover of Volume 17, Issue 3, titled “Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer's disease.” In this study, a research team from Dalhousie University, led by Sultan Darvesh, discovered that certain anti-aging compounds, known as senolytics, can block harmful brain enzymes linked to Alzheimer's disease (AD) without affecting healthy ones. Senolytics are compounds that help clear out damaged or “zombie” cells that build up with age and contribute to inflammation and tissue dysfunction. This work provides new insight into how AD-related damage can be precisely targeted, leading the way for safer treatments that protect memory and brain health in older adults. Alzheimer's disease is one of the most common causes of memory loss and dementia. A hallmark of the disease is the buildup of sticky protein clumps in the brain, known as amyloid-beta plaques. Two enzymes—acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)—are found near these plaques. While these enzymes play important roles in brain function, they can also contribute to AD progression when they attach to plaques. Drugs that target these enzymes are already used to help with memory, but they often block both harmful and healthy forms, which can cause unwanted side effects. To investigate a better solution, researchers tested six compounds that are known for their anti-aging or brain-boosting properties. They wanted to know if these compounds could block only the harmful AChE and BChE enzymes forms linked to Alzheimer's disease. Using brain tissue samples from AD patients and enzyme activity assays, they discovered that compounds such as dasatinib and nintedanib, both senolytics, were able to block the forms of AChE and BChE associated with amyloid-beta plaques. These compounds did not affect normal brain enzymes, though. “We show that the selected senolytics and nootropic inhibit ChEs associated with plaques but not the enzymes associated with normal neural elements.” The study also used computer modeling to explore how these compounds interact with the enzymes. The models showed that the enzymes change shape when near plaques, making them easier for certain compounds to target. This change may explain how the drugs can selectively affect only the diseased areas of the brain. While not all compounds worked equally well, the findings offer a new strategy for treating AD. By focusing on the differences between healthy and diseased enzyme forms, researchers may be able to design more precise and effective therapies. This selective approach could improve memory, reduce inflammation, and avoid the side effects of AD's current treatments. In summary, this research opens new possibilities for treating Alzheimer's disease in a more targeted way. It also highlights how discoveries in aging and brain health can work together to create better therapies for neurodegenerative diseases. DOI - https://doi.org/10.18632/aging.206227 Corresponding author - Sultan Darvesh - sultan.darvesh@dal.ca Video short - https://www.youtube.com/watch?v=CJQFpG9Jn6Y Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206227 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Biohacking for Longevity: Extending Your Health Span. In this episode of "Leyla Weighs In," registered dietician and nutritionist Leyla Muedin discusses the concept of biohacking and its potential to extend lifespan and health span. Leyla explores various biohacking strategies such as diet optimization, regular physical activity, stress management, enhancing sleep quality, and maintaining strong social connections. She emphasizes the importance of epigenetics, targeted lifestyle changes, and advanced medical interventions like stem cell therapy. You will learn practical biohacking tips, including the benefits of intermittent fasting, the significance of exercise, and how to use wearable technology for health tracking. Leyla also highlights the role of supplements and personalized nutrition in promoting longevity, alongside maintaining good dental health and a sense of purpose. Through these combined efforts, Leyla aims to inspire listeners to not only live longer lives but to enjoy better health and vitality.

Christian Asare, MD, joins Integrative Practitioner Content Specialist Avery St. Onge to discuss the connection between chronic pain, aging, and cellular senescence in a live interview at the 2025 Integrative Healthcare Symposium. About the Expert Asare B. Christian, MD, MPH, is a board-certified integrative and regenerative pain management specialist and the founder of Aether Medicine in Wayne, Mainline Philadelphia. Aether Medicine focuses on cellular health to alleviate pain, enhance performance, and extend healthspan. Dr. Christian integrates various medical disciplines, including pain management, cellular medicine, neurorehabilitation, and longevity medicine, with personalized lifestyle modifications. His approach is characterized by empathetic patient care and a profound understanding of medical science, tailored to individual health solutions.

Support the show and get 50% off MCT oil with free shipping – leave us a review on iTunes and let us know!Aging isn't just about the years you accumulate—it's about how well your body holds up along the way. According to Dr. Gregory Kelly, the key to longevity isn't just diet and exercise—it's eliminating the "zombie cells" that could be making you age faster than you should.Dr. Kelly is a naturopathic physician, author, and a leading researcher on senolytics—the compounds that target senescent cells (aka zombie cells) to improve health and extend lifespan.In this episode, Dr. Kelly shares why these "zombie cells" linger in our bodies, how they contribute to chronic inflammation, and what you can do to clear them out. He also breaks down the latest research on senolytics, the connection between cellular aging and joint pain, and why intermittent dosing could be the key to unlocking better health as you age."The zombie analogy is used so much because they're not alive, they're not dead, and they can create new versions of themselves that are also not alive and not dead." ~ Dr. Gregory KellyAbout Dr. Gregory Kelly:Dr. Gregory Kelly is a naturopathic physician and lead researcher at Neurohacker Collective. He has published extensively on natural medicine, nutrition, and the science of aging. His expertise spans from engineering to Southeast Asian studies and naturopathic medicine, giving him a unique perspective on longevity and human health.Resources Mentioned:Qualia Senolytic: https://www.qualialife.com/livebeyond Connect with Dr. Gregory Kelly:- Qualia Website: https://www.qualialife.com/ - Qualia X: https://x.com/qualialifeco - Instagram: https://www.instagram.com/qualialife/ - YouTube: https://www.youtube.com/neurohacker - Podcast: https://podcasts.apple.com/us/podcast/collective-insights/id1293899173 Connect with Chris Burres:- Website: https://www.myvitalc.com/ - Website: http://www.livebeyondthenorms.com/ - Instagram: https://www.instagram.com/chrisburres/ - TikTok: https://www.tiktok.com/@myvitalc - LinkedIn: https://www.linkedin.com/in/chrisburres/ 

In this sponsored interview, Andrea Donsky, nutritionist, menopause educator, published menopause researcher, and co-founder of Morphus, discusses senolytics with Dr. Gregory Kelly - Director of Product Development at Qualia Life Sciences, naturopathic physician, and author of "Shape Shift."Women in perimenopause and menopause should explore the benefits of senolytics for cellular aging because of the impact on their menopausal symptoms and overall health. During menopause, there's an accelerated accumulation of senescent cells (zombie cells) in the body, which can trigger inflammation, joint pain, and other age-related issues that make menopausal symptoms more challenging to manage. Understanding these changes helps women take steps to help them feel better and improve their long-term health. Senolytics are used only a couple of days a month, but the benefits can be felt, especially as shown by the studies done on joint pain.Key Points:Explore how cellular aging affects women during perimenopause and menopause.When cells have trouble producing energy and the body's repair cells decline, menopausal symptoms can become more severe.Discover what senescent cells ("zombie cells") are and why they accumulate more after menopause.Learn how senolytic compounds can help remove accumulated senescent cells contributing to joint pain and other issues.Understand why an intermittent approach to senolytics (2 days per month) is more effective than daily supplementation.Get practical tips for using senolytics safely and effectively during your menopause journey.Save 15% on Qualia Life Senolytics https://bit.ly/42mtvmx CODE MORPHUS15Follow Qualia Life on Instagram https://www.instagram.com/qualialife?igsh=anBzMXVkazViN3NyDr. Gregory Kelly's Book: Shape Shift: The Shape Intelligence Solution https://amzn.to/42RCbkSSend us a text ✅ Fill out our surveys Support our SPONSORS: Qualia https://bit.ly/42mtvmx CODE MORPHUS15 BEAM Minerals https://bit.ly/41DCG1w Code MORPHUS EnergyBits https://bit.ly/49f05YV Code MORPHUS Livon: https://bit.ly/3EjrcGG CODE MORPHUS Order 1 carton of Lypo-Spheric® Vitamin C at LivOnLabs.com & get 1 carton of B Complex Plus FREE ($56 value) just by adding both products to the cart Timeline: timeline.com/morphus CODE MORPHUS

Subscribe to our channel: https://www.youtube.com/@optispan In this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of personalized medicine in aging research, emphasizing the need for careful interpretation of scientific data. 00:00:00 - Should Matt be skeptical of the 40% life extension figure for caloric restriction? 00:06:43 - Can calorie restriction be combined with other interventions like Rapamycin or Senolytics? 00:11:30 - Does metformin or berberine have significant effects on longevity? 00:14:51 - Is pea protein powder a good dietary choice for a complete protein? 00:17:33 - What are the best ways to increase VO2 max? 00:20:12 - Longevity Fads? 00:22:45 - How does cold exposure affect inflammation? 00:26:05 - How does NAD+ supplementation compare to NMN for longevity? 00:29:11 - What role does sleep quality play in overall lifespan? 00:32:00 - Can mindfulness or meditation improve biomarkers related to aging? 00:35:22 - Is there evidence that probiotics can extend lifespan? 00:38:45 - How does alcohol consumption affect aging and longevity? 00:41:10 - What are the best supplements for improving cognitive health with age? 00:45:00 - Are there specific dietary patterns proven to slow biological aging? 00:48:25 - How effective is Rapamycin when started later in life? 00:52:10 - Can exercise offset the negative effects of a poor diet? 00:55:34 - Is there a link between gut health and lifespan? 00:58:20 - What are the biggest misconceptions about anti-aging interventions? 01:06:33 - Do you track fiber intake? 01:07:45 - What's the common misconception about mTOR? 01:09:33 - Are there ongoing studies comparing rapamycin to other mTOR inhibitors in terms of safety and effect? 01:11:48 - Favorite band? 01:11:52 - How can a non-scientifically trained person tell good science from bad? Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/

Angela presents the second of a two part conversation with Dr Gregory Kelly, in which they discuss the intriguing topic of senescent cells, often referred to as "zombie cells." These cells accumulate with age, resist apoptosis, and contribute to inflammation, negatively impacting overall health and vitality. Dr. Kelly explains the mechanisms behind cellular senescence and introduces the concept of senolytics—compounds designed to help clear these dysfunctional cells from the body KEY TAKEAWAYS Senescent cells, often referred to as "zombie cells," resist apoptosis (cell death) and accumulate with aging. They do not contribute to bodily functions and instead release inflammatory compounds that can lead to various age-related health issues. Senolytic compounds are designed to help clear out senescent cells from the body. By periodically taking these compounds, individuals can promote cellular health and potentially improve energy levels, joint comfort, and overall vitality. The process of using senolytics can be likened to pruning yellow leaves from a plant. Just as removing unhealthy leaves allows for new growth, clearing out senescent cells can help rejuvenate tissues and promote healthier cellular function. It is suggested that individuals start considering senolytics around the age of 40, especially if they have experienced significant stress or health issues. Younger individuals may not need to use them as frequently, while older adults may benefit more from regular use. BEST MOMENTS "Senescent cells resist cell death, are unrepairable, and secrete inflammatory compounds, contributing to aging and various health issues."  "If exercise was a pill, everyone would take it because it stimulates autophagy and helps slow the accumulation of senescent cells."  "Senolytics are compounds that can finally get a senescent cell to change its mind and go through this falling off process."  "If we want a different result than our parents or grandparents, we have to start doing more and start doing it younger." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community Save 15% on Qualia Mind with Code ANGELA15 at http://www.qualialife.com/angela Check out Leela Quantum Technology and save 10% with code ANGELA at www.leelaq.com ABOUT THE GUEST Dr. Gregory Kelly is a naturopathic physician (N.D.). He is Vice President of Product Development at Qualia Life Sciences and author of the book Shape Shift. He was an editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Nutrition and Counseling Skills. Dr. Kelly has published numerous articles on various aspects of natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of special interest and expertise include nootropics, anti-aging and regenerative medicine, weight management, and the chronobiology of performance and health. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. 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Six conditions cause the majority of deaths in the world, these include dementia and cardiovascular disease. Traditionally, we've looked at these conditions through the lens of what goes wrong individually, such as blocked arteries around the heart or tangles of proteins that impair electrical signalling in the brain. But the common denominator is actually ageing.As grandiose and esoteric as that sounds, ageing and the processes that govern ageing are what we need to be tackling if we want to better manage or even prevent these conditions of older age.And with me to discuss why and how we age is Richard Faragher. He's Professor of Biological Gerontology at the University of Brighton, and has dedicated his career to understanding the ageing process and what we can do to improve this inevitable phase of life.As you can tell from today's episode, Richard is a passionate advocate for older people and can wax lyrical about the history of the gerontology field.A few definitions before we dive into the episode I think will be helpful for people who are new to the research.There are agreed “hallmarks” of ageing that are a description of processes, such as metabolism and DNA repair functions, that go awry as we grow older. Ageing is caused by these changes at the molecular level that lead to downstream effects like disease and degeneration.Cell senescence is what happens at the end of a cell's lifespan, where they become dysfunctional and need to be removed by immune cells. However in older age, it can become more troublesome for your immune system to clear away these senescent cells and increasing inflammation ensues.Senolytics are compounds or drugs that have been designed to selectively eliminate these senescent cells. And the hope is that they can mitigate a range of age-associated conditions like arthritis, cataracts, dementia and more.Trigger warning. We discuss a graphic analogy for senescent cells using suicide, so I just wanted to give a heads up for anyone who might find that analogy uncomfortable.

Send me a text!Have you ever heard of Senolytics? It's the latest breakthrough in aging and longevity science that I honestly had not heard about until learning about Qualia Senolytic. That's what I'm SO excited to welcome todays guest, naturopathic physician Dr. Gregory Kelly, the VP of product development at Qualia Life, and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. In this episode, Dr. Kelly and I discuss why you should care about cellular senescence and how its different from autophagy, the hallmarks of aging, the, and how you can age better at a cellular level by helping your body naturally eliminate senescent cells. Suggested Resources:Qualia Life (you can use the code wellnstrong for a discount!Dr. Gregory Kelly Qualia Senolytic Placebo-Controlled Clinical Study ResultsSenolytic drugs: from discovery to translationQualia Senolytic combines 9 vegan, plant-derived compounds to help your body naturally eliminate zombie (or senescent) cells, that help us age better at the cellular level so we can feel YEARS younger! Use the code WELLNSTRONG for 15% off!Join the WellnStrong mailing list for exclusive content here!Want more of The How To Be WellnStrong Podcast? Subscribe to the YouTube channel. Follow Jacqueline: Instagram Pinterest TikTok Youtube To access notes from the show & full transcripts, head over to WellnStrong's Podcast Page

BUFFALO, NY- October 22, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on September 26, 2024, entitled, “Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model.” Pelvic organ prolapse is a common condition among women in the U.S., with a 13% estimated risk of requiring surgery by age 80. Senolytic agents like dasatinib and quercetin (D+Q) target age-related cellular senescence and reduce senescent cell activity in various disease processes. In their paper, researchers Erryn Tappy, Haolin Shi, Jessica Pruszynski, and Maria Florian-Rodriguez from the University of Texas Southwestern Medical Center, Department of Obstetrics and Gynecology in Dallas, utilized a mouse model of pelvic organ prolapse, Fibulin-5 knockout (Fbln-5-/-) mice, to assess the ability of D+Q to prevent development of prolapse. The D+Q injections administered did not result in significant differences in prolapse development but did reduce cellular senescence markers in Fbln-5-/- mice. This suggests senolytic agents may help mitigate the role of cellular senescence in tissue dysfunction associated with prolapse. The researchers suggest that further studies are needed to determine optimal timing, dosage, and delivery of senolytics for prolapse prevention. "This study represents one of the first to evaluate the impact of senolytic agents D+Q on the clinical development of pelvic organ prolapse and expression of proteins associated with cellular senescence in a mouse model.” DOI - https://doi.org/10.18632/aging.206120 Corresponding author - Maria Florian-Rodriguez - Maria.Florian-Rodriguez@UTSouthwestern.edu Video short - https://www.youtube.com/watch?v=kTQfjhubx_4 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206120 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, pelvic organ prolapse, cellular senescence, senolytic agents, animal model About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Hey everyone.Today, I've got a fantastic guest on the show - Dr. Gregory Kelly from Neurohacker Collective. You may have heard of them from their game-changing supplements, but today, we're going beyond the bottle. We're getting into the fascinating world of senolytics, talking about ageing intelligently, and exploring whether you might be a ‘super responder' - and trust me, that's a good thing! Dr Gregory is not only a brilliant naturopathic doctor and an author, but he's also a great storyteller with some incredible insights to share. You're in for a treat with this one. Let's get right into it!Highlights:(3:47) Dr. Kelly's journey to naturopathic medicine (7:54) Qualia and the concept of senolytics (21:11) The development of qualia senolytic (27:31) The role of senolytics in health and ageing (54:46) The future of senolytics and health research (55:33) Dr. Kelly's philosophy on health and wellness Find out more about Dr Gregory Kelly:Website - LinkedIn - Instagram - Facebook - TwitterVisit Nicole's on demand fitness platform for live weekly classes and a recorded library of yoga, strength training, guided audio meditations and mobility (Kinstretch) classes, as well: https://www.sweatandstillness.comGrab Nicole's bestselling children's book and enter your email for A FREE GIFT: https://www.yolkedbook.comFind Nicole on Instagram:https://www.instagram.com/nicolesciacca/Tik Tok: https://www.tiktok.com/@thenicolesciaccaFacebook: https://www.facebook.com/nicolesciaccayoga/Youtube:https://www.youtube.com/channel/UC1X8PPWCQa2werd4unex1eAPractice yoga with Nicole in person in Santa Monica, CA at Aviator Nation Ride. Get the App to book in: https://apps.apple.com/us/app/aviator-nation-ride/id1610561929Book a discovery call or virtual assessment with Nicole here: https://www.calendly.com/nicolesciaccaThis Podcast is Proudly Produced by The Podcast BoutiqueMentioned in this episode:www.Neurohacker.com/shockandyall and use the code SHOCKANDYALL to get 15% off your first order

My guest in this cutting edge episode is Greg Kelly from Qualia Senolytic. Greg will be diving into cellular senescence – and together we're unveiling the secrets behind reversing age. Why? Because with the latest studies and emerging research, it's clear that tackling senescent cells could be a game-changer in the quest to slow down the aging process. These "zombie" cells don't just age us, they wreak havoc on our health, setting the stage for age related issues. And believe me, I was as curious as anyone about how we could possibly combat these senescent cells until we started peeling back the layers. It turns out, the answer might be senolytics – natural and pharmaceutical compounds showing promise in eliminating these problematic cells. We're talking about quercetin, fisetin, and other potent allies that can pave the way for healthier, longer lives. So, we're here to pass on this crucial information to you – chew on it, see where it fits, and maybe get started on your own journey of age reversal. Connect with Qualia Senolytic: http://neurohacker.com/thyroid Use the code THYROID for 15% off your order Shop ALL of Dr. Amie's Fixxr® Supplements: betterlifedoctor.com LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free application call: https://dramiehornaman.com/pages/book-a-call FREE DOWNLOADS… What Are the Optimal Lab Ranges? What Steps Can I Take? Don't know where to start...don't know which labs are useful? And what to do when you get your results? “How To” Guide For Supplements Here's your Fixxr® supplement timeline and guide. Fix Your Thyroid and Adrenals To Fix Your Life Check your symptoms of hypothyroidism and know OPTIMAL thyroid lab values. Learn why you are being told you're “NORMAL” by your doctor. Can Supplements Help with Hypothyroidism? Grab this thorough guide to help you select the most advantageous supplements that will best suit your health circumstances. RATE, REVIEW AND FOLLOW ON APPLE PODCASTS Show your love for Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE, scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review. Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group, Dr. Amie…The Thyroid Fixer®...Love Your Mirror, for a Community of HOPE and Support in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine Subscribe on Youtube: Dr. Amie Hornaman Follow me on Instagram: @dramiehornaman

Are you curious about the science behind aging and how to potentially slow it down?Aging gracefully and maintaining a vibrant, healthy life is a universal desire, and in this episode of The Biohacking Bestie podcast, I talk with Dr. Gregory Kelly about the secrets to achieving just that. Dr. Greg Kelly is a leading expert in the field of aging and senescent cells, and we discuss how we can extend not just our lifespan but our health span too. We also dive into the 12 hallmarks of aging, the power of senolytic compounds, the innovative supplements from Qualia, which are backed by rigorous research, and more. Gregory Kelly is Director of Product Development at Neurohacker Collective, a naturopathic physician (N.D.), and the author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed.Listen as we discuss…(00:01) Understanding Senescent Cells and Aging(10:56) Senescent Cells and Aging Interventions(19:43) Senolytics(25:59) Optimal Timing for Senolytic Supplementation(34:56) Senolytics and Aging Implications(49:50) New Innovation in Natural Supplements(55:29) Exploring Qualia Life Supplements… and more! Grab my brand-new book: Biohack Like a Woman. Order now on Amazon: http://bit.ly/3TYMz5Z Find more from Aggie: Start optimizing your health here: https://biohackingbestie.com/Get daily Biohacking Bestie tips here: https://www.instagram.com/biohackingbestie/Get a 7-Day FREE meal plan here: https://www.fitasfuck.co/mealplanFind more from Dr. Greg Kelly:Website: https://www.qualialife.com/people/greg-kelly Instagram: @qualialifeHosted on Acast. See acast.com/privacy for more information. Hosted on Acast. See acast.com/privacy for more information.

I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis. Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you're using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Alessandra Zonari, PhD OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin's biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals. Email: alessandra@oneskin.co THANKS TO OUR SPONSOR OneSkin: Website PROMO Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website SHOW NOTES Animated science video explaining how OS-01 works Another Study Website Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website MolClock: Estimate DNA methylation age of Skin Tissues Study Website Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

In this episode of the Wild Health Podcast, Dr. Mike Mallin sits down with Dr. Gregory Kelly to explore the fascinating world of cellular senescence and senolytics. Cellular senescence, a state where cells cease to divide and function properly, is a critical aspect of aging. Dr. Kelly delves into the mechanisms behind senescence, the impact of senescent cells on our health, and the groundbreaking potential of senolytics—compounds designed to selectively target and eliminate these "zombie cells." Join us as we cover: The basics of cellular senescence and why it matters. The dual theories of aging: programmed aging vs. damage accumulation. The discovery and evolution of senolytics, from early genetic modifications in animals to the latest research on compounds like quercetin and fisetin. The mechanisms by which senolytics work and their role in promoting cellular health. Practical insights into how senolytics can be used, including the importance of dosage and the concept of "hit and run" dosing. The story behind Neurohacker Collective's Qualia Senolytic, a supplement designed to harness the power of senolytics for improved joint health, energy, and overall wellness. Whether you're a health enthusiast or simply curious about the latest advancements in longevity science, this episode is packed with valuable information and actionable insights. Tune in to learn how you can take control of your aging process and enhance your health span with the power of senolytics. Visit neurohacker.com/wildhealth and use the code wildhealth for 15% off Qualia Senolytic and other cutting-edge health products.

Do you know what senescent (zombie) cells are and how cellular senescence and senolytics impact health? In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. This episode is a deep dive into aging research, cellular senescence, and senolytics. Dr. Kirkland discusses the impact of cellular aging (senescence) on healthspan and his discovery of the first senolytic agents that remove senescent cells and extend healthspan, illuminating his pioneering work in aging research.Dr. Kirkland shares insights into the science of cellular senescence and how selectively eliminating these cells could revolutionize the treatment of age-related chronic diseases. He sheds light on the mechanisms behind senolytics and their promise for extending healthspan. The discussion also touches on the importance of lifestyle factors like diet and exercise in managing senescent cells. Dr. Kirkland also discusses geroscience, a research paradigm that seeks to understand the mechanisms of aging and how this knowledge can be used to slow the rate of aging, reverse its effects, delay or even cure age-related diseases, and extend healthspan. T Dr. Kirkland also covers the challenges and opportunities in translating these scientific discoveries into clinical applications, emphasizing the critical role of interdisciplinary efforts in advancing our understanding and management of aging.This is an enlightening episode with Dr. Kirkland on aging research and the opportunities to revolutionize healthcare by combating aging-related diseases and extending people's health span and lifespan.Timestamps:Introduction: 00:00-03:49What led Dr. James Kirkland to become a physician-scientist and become interested in aging research?: 03:50-05:24What is geroscience, and what are fundamental aging processes?: 05:25-09:17What are the differences between targeting aging vs. the traditional medical system of waiting to treat illnesses or diseases after they occur?: 09:18-12:39What are gerotherapeutics, and what is their relevance for healthspan and lifespan?: 12:40-16:10What are senescent cells? What is the impact of senescent cells on the body and aging: 16:11-26:39What are senolytics? How do senolytics work to target senescent cells to remove them?: 26:40-35:05How Dr. James Krikland discovered senolytics such as fisetin, quercetin, and dasatinib? What clinical trials on the effects of senolytics in humans have been done? 36:06-40:47Discovering biomarkers for senescent cells: 40:48-42:37What are some important factors to consider on the effects of gerotherapeutics and senolytics on lifespan and healthspan in model organisms compared to humans?: 40:38-47:39The potential for geroscience and gerotherapeutics, such as senolytics, to transform healthcare. What is the importance and what are some challenges of conducting clinical trials on gerotherapeutics, such as senolytics, to improve healthspan in humans?: 47:40-56:15What is the Translational Geroscience Network, and what are its goals?: 56:16-01:02:01How might senolytics be used clinically in the future if proven safe and effective? What conditions might they benefit?: 01:02:02–01:05:57What are the effects of lifestyle, such as diet and exercise, on senescent cells?: 01:05:58-01:06:52What excites Dr. James Kirkland the most about the potential for extending people's healthspan and lifespan with therapies, drugs, or interventions in the coming years?: 01:06:53-01:07:41Dr. Kirkland's top tip for health? 01:07:42-01:12:14

Join me as I sit down with the insightful Dr. Greg Kelly from Neurohacker Collective to unpack the complexities of aging and brain health. Listen in as we explore the intriguing theories behind why we age – is it a programmed deterioration or an accumulation of cellular damage? Dr. Kelly shares his expertise on how lifestyle choices impact our cellular vitality and introduces us to the concept of cellular senescence. Go to neurohacker.com/REALFOODOLOGY for up to $100 off and use code REALFOODOLOGY at checkout for an additional 15% off.  Topics Discussed: 0:10:55 - Supplement Stacking Options 0:13:54 - Cellular Senescence and Aging Process 0:22:08 - Understanding Senescent Cells in Aging 0:27:11 - Senolytics & Cellular Rejuvenation 0:30:57 - Targeting Senescent Cells for Healthy Aging 0:38:28 - Individual Responses to Supplements 0:42:58 - Benefits of Quality Supplements and Probiotics Sponsored By: Neurohacker Go to neurohacker.com/REALFOODOLOGY for up to $100 off and use code REALFOODOLOGY at checkout for an additional 15% off.  Check Out Courtney: @realfoodology My FREE Grocery Guide Leave Me a Message! Air Dr Air Purifier AquaTru Water Filter Produced By: Drake Peterson Edited By: Mike Frey

BUFFALO, NY- March 6, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions.” Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. In this new study, researchers Edwin Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner, Aaron Lin, Tavis L. Mendez, Hannah Went, Alan Tomusiak, Eric Verdin, Michael Corley, Lishomwa Ndhlovu, Ryan Smith, and Varun B. Dwaraka from the Institute For Hormonal Balance, TruDiagnostic, Buck Institute for Research on Aging, and Cornell University aimed to assess the effects of senolytic treatments on DNA methylation (DNAm), epigenetic age, and immune cell subsets. “[...] this study aims to comprehensively assess the impact of senolytic drugs on epigenetic aging through two longitudinal studies to address our research objective. The initial investigation focuses on a combination treatment of Dasatinib and Quercetin, while the subsequent phase incorporates Fisetin into the treatment regimen.” In a Phase I pilot study, 19 participants received Dasatinib and Quercetin (DQ) for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic age acceleration were observed in first-generation epigenetic clocks and mitotic clocks at 3 and 6 months, along with a notable decrease in telomere length. However, no significant differences were observed in second and third-generation clocks. Building upon these findings, a subsequent investigation evaluated the combination of DQ with Fisetin (DQF), a well-known antioxidant and antiaging senolytic molecule. After one year, 19 participants (including 10 from the initial study) received DQF for 6 months, with DNAm assessed at baseline and 6 months. Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging. “Furthermore, our analyses unveiled notable differences in immune cell proportions between the DQ and DQF treatment groups, providing a biological basis for the divergent patterns observed in the evolution of epigenetic clocks. These findings warrant further research to validate and comprehensively understand the implications of these combined interventions.” DOI - https://doi.org/10.18632/aging.205581 Corresponding authors - Varun B. Dwaraka - varun@trudiagnostic.com Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Nick Bitz is a Naturopathic Physician who specializes in Ayurvedic medicine. He is an expert in the natural products industry and is the Senior VP of Product Development at Neurohacker Collective. His expertise includes nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements.In our latest dialogue, we delve into the ancient art of Ayurvedic medicine. Imagine a life where your unique body type is the compass that guides every health and wellness decision you make. Through our in-depth discussion, you'll discover the foundations of Ayurveda and how tapping into the Kapha, Pitta, and Vata doshas can be the key to unlocking a vibrant, balanced lifestyle. Dr. Nick reveals how you can weave these time-tested principles into your modern life.Dive into the heart of Ayurveda with us and grasp how the language of Sanskrit connects us to the universe, how Ayurvedic philosophy transcends diet to touch every aspect of our lives, and how understanding your dosha can shape your path to well-being. I illuminate the importance of aligning lifestyle choices with your body's needs with personal anecdotes and practical advice. We touch on the synergy of Ayurveda and yoga, the therapeutic cadence of "ohm," and how practices like pulse diagnosis can offer insights into your health that transcend what any online questionnaire can provide.To try Neurohacker's highly advanced and researched products, go to https://neurohacker.com and use my code SANDYK for a discount.Past Episodes with Dr. Nick and Neurohacker:Episode 162 on Senolytics & Aging:  https://podcasts.apple.com/ca/podcast/sandy-k-nutrition-health-lifestyle-queen/id1496677282?i=1000612129322Episode 203 on Gut Health:  https://podcasts.apple.com/ca/podcast/sandy-k-nutrition-health-lifestyle-queen/id1496677282?i=1000643338637This podcast episode is sponsored by Sigrid Glucose Stabiliser.  Sigrid Blood Glucose Stabiliser:  Go to https://sigridstabiliser.com/  and use code SandyK15 for a discount.My Essential Thyroid Guide is now available on all Amazon stores!US:  https://www.amazon.com/dp/B0CW4X3WJDCanada:  https://www.amazon.ca/dp/B0CW4X3WJDSupport the showPlease remember to subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgTwitter: https://twitter.com/sandyknutrition

The longevity research world is exploding right now, it's so exciting and the technology is advancing in leaps and bounds and we are able now to discover faster than ever before thanks to AI and co to test more molecules that can impact human health than ever before in the history of mankind. What would have taken years now takes weeks or months. In this episode I talk to Michael Antonelli CEO and founder of Healthgevity. Michael is a master formulator who has spent decades in the anti-ageing and longevity space learning at the feet of many masters and who is at the forefront of working with companies at the cutting edge in peptide and bioactive ingredient development.    All his formulations are science backed with clinical research and I was excited to learn about something of these novel molecules like Peptistrong, Astragin, Factor 21, NAD3, Ameal Peptide and many more.   In this episode Michael walks us through some of the cutting edge molecules, what they do and how they impact various biological pathways to  hopefully improve our healthspan and lifespan.   If after listening to this episode you want to check out some of the range we now have in our shop. Click the links below:   Ignite  -Metabolic health and weightloss  Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency. Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support: Reduction of adiposity and visceral fat* Increase thermogenesis by raising the metabolic rate and calorie burning* Browning of white adipose tissue* Diet-induced weight gain* Increase fatty acid oxidation* Ramp up ketone levels* Improves glucose tolerance and glucose control* AMPK activation* Leptin and ghrelin levels* Regulation of a healthy metabolism and mitochondrial health*   Longevity  Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong™, Senactiv® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age. In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span.  Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity.  Recent discoveries of clinically proven 'growth promoting' ingredients have made the process of building and preserving muscle more obtainable.  PeptiStrong™, Senactiv® and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health.  CARDIO NAD+ Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. Featured Supportive Benefits: Improves net NAD+ status by supporting both its synthesis and limiting its degradation Supports healthy blood pressure Improves vascular aging and endothelial function Supports healthy fibrinolytic activity and clotting function Promotes healthy circulation and blood flow Inhibits platelet & red blood cell aggregation Decreases blood viscosity Supports clinical measures of inflammation Supports healthy blood sugar and insulin levels Inhibits lipid peroxidation Supports healthy lipid metabolism Demonstrated reduction in various independent cardiovascular risk factors Rejuvenate Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body.  Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process.  Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly.  Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it.  Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span.  Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells. Rejuvenate presents a unique solution for intervention through two mechanisms:  (1) eliminating senescent cells (senolytics)   (2) inhibiting of senescent- associated secretory phenotype (SASP)  Featured benefits:  Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo. Targets aging at the cellular level Induces autophagy to promote intracellular recycling and cellular renewal Reduce full body features of Senescence-Associated Secretory Phenotype (SASP). Protects cells against free radicals and oxidative stress  Targets inflammaging at the cellular level and supports a healthy inflammatory response Supports a healthy immune system  Formula designed to also treat muscle senescence. Exercises muscles longer and harder with a boost in citrate synthase activity. Recovers more effectively with a reduction in inflammation biomarkers. Decreases SA-β-Gal by 63% in muscle tissue.     For more information on Michael and Healthgevity you can also go to www.healthgev.com   BIO Throughout a career spanning over 17 years, Michael passionately devoted himself to pioneering methods aimed at enhancing longevity, optimizing healthspan, and elevating overall quality of life. His focus revolves around collaborating with leading healthcare professionals, researchers, and other likeminded healthcare leaders to create natural solutions that elevate patient outcomes.  Michael utilizes his past experiences that integrates a diverse range of therapies and services, spanning from precision diagnostics to practice management strategies, hormone optimization, nutritional supplements, and leveraging peptides. Previous roles included Chief Innovation Officer, Executive Director, and Business Development for leading companies within the healthcare industry before founding Healthgevity. His expertise extends beyond conventional approaches, emphasizing holistic well-being and personalized care as essential components to any successful medical practice.  By championing novel methodologies and innovative technologies, Michal facilitates transformative changes within the healthcare landscape, fostering advancements that positively impact both practitioners and the individuals they serve.  Michael continues to remain dedicated to the pursuit of innovative strategies that enhance health and vitality while reshaping the paradigms of healthcare.   Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.   Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.   To pushing the limits, Lisa and team

As the year comes to an end, Rick and Vicky will wrap the year up with discussions about the health trends of 2023 and what to expect in 2024.Whether you're curious about the latest superfoods, intrigued by cutting-edge fitness routines, or interested in mental health breakthroughs, we've got you covered. Get ready to embark on a journey toward a healthier, happier you.Chapter markers:02:04 -  Microbiome Cleanse & Reset08:36 - Supplements for Telomere Health12:56 - Natural Senolytics15:22 - Psychodermatology25:12 - Menopause support and functional foods31:08 - Berberine35:00 - Genomic Medicine37:06 - Sound Bathing40:10 - Hydration / Electrolyte drinks Stay informed, follow us on socials and subscribe to our YouTube Channel. Instagram: @obornehealthFacebook: @obornehealthYouTube: https://youtube.com/playlist?list=PLFEYFZfOKEyxU48TeAGD-Kg0mNIyUEoTGRick Hay & Vicky Tsoleridis --DISCLAIMER: All information provided via The Health Chat is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for independent professional advice. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health. Oborne Health Supplies does not supply to the general public. Thank you.

Angela talks to Dr Chris Shade, Chris about the concept of longevity and the creation of the Longevity Wheel. The Longevity Wheel is a graphical representation of the key factors that contribute to longevity, including Nrf2 and AMPK activation, NAD optimization, sirtuin activation, telomere maintenance, senolytics, and the neuroendocrine system. Dr Shade explains how each of these factors plays a role in promoting longevity and discusses the importance of supplementation and lifestyle choices in optimising these pathways. The conversation also touches on the impact of genetics, the role of inflammation in aging, and the benefits of fasting and exercise KEY TAKEAWAYS The Longevity Wheel is a graphical representation of the key factors that can affect longevity. It includes Nrf2 and AMPK at the top, followed by NAD, sirtuins, telomeres, senolytics, and the neuroendocrine system. These factors can be targeted through supplementation to promote a younger version of the body. NAD levels naturally decline with age, and this decline can be accelerated by inflammatory processes. Supplementing with NAD precursors, such as NMN or NR, can help maintain NAD levels and support mitochondrial function. It is important to balance NAD supplementation with adequate methyl donors to avoid potential side effects. Telomeres are protective caps at the ends of chromosomes that shorten with age. When telomeres become too short, cells enter a senescent state, characterized by inflammation and reduced cell growth. Senolytics, such as quercetin and fisetin, can help remove senescent cells, while maintaining optimal glutathione levels and Nrf2 activation can support telomere health. Fasting and exercise can stimulate autophagy, AMPK activation, and ketone production, which are beneficial for longevity. Intermittent fasting, especially during specific phases of the menstrual cycle for women, can optimise these processes. BEST MOMENTS "The AMPK charge has berberine and resveratrol and cinnamon, which are strong AMPK activators." "Fasting reboots the immune system. It reboots all kinds of stuff. Often, we want to be able to reverse everything without changing our diet, without doing something like fasting, but you need to do that." "You need a lot of methyl groups for those people. And then the more under stress you are, the more methyl groups you generally need." "Fasting stimulates all of this stuff. Fasting is so freaking good because fasting stimulates all of this stuff. Fasting reboots the immune system." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health CommunityFree Fasting Guide - www.angelafosterperformance.com/fastingPodcast Shownotes - www.angelafosterperformance.com/podcasts The Longevity Wheel - https://www.quicksilverscientific.com/longevity-wheel/ ABOUT THE GUEST Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, continues tobe a driving force of development and innovation in Functional and IntegrativeMedicine, creating high-efficacy detoxification systems for wellness and longevityby employing high-bioavailability delivery systems for nutraceuticals and whole-plant extracts. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedInThis show was brought to you by Progressive Media

In this captivating episode of "Health & Fitness Redefined", host Anthony Amen is joined by Amitay Eshel from Young Goose Biohacking Skincare. Together, they explore the world of skin health, offering invaluable tips and tricks to achieve radiant skin. Delve deep into the science behind NAD+ Boosters, Resveratrol, and Senolytics, and discover how these compounds can revolutionize your skincare routine. Whether you're a skincare enthusiast or just looking to enhance your skin's health, this episode is packed with insights you won't want to miss. Special thanks to our sponsor, F2 Consulting. Exclusive for our listeners: Get 10% off all services at www.fitbodiesfatwallets.com.Athletic Brewing Company Enjoy Beer? Enjoy Being active? Have you ever considered NA Beer?! WELCOME TO THE BEST NA BDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show

Dr. Morgan is an expert in Functional and Integrative Medicine with a Strong Emphasis in:Bio-Identical HormonesLongevity & Regenerative MedicineChronic InfectionsImmune-TherapyDetoxificationGI HealthStress-Related illnesses In addition to his 20 years of work in Functional Medicine, he has expanded his practice to include work on the deeper aspects of our being that point to the root cause of our illnesses working with Mind Body Wellness, Energy Medicine, and Healing with Consciousness. Dr. Morgan Practices in the Bay Area.  He loves hiking, swimming, meditating, working out, cooking, skiing & yoga.  He is passionate about the evolution of consciousness and the inter-relatedness of our health, our beliefs, and our state of mind.   We will discuss:1.  Block Mtor1 and the production of senescent cells with rapamycin Dr Alan Green 6 mg dosing. Dr Mogan uses between 2- 4 mg  Weekly motr1 supressing, no immune suppression. 2. Take senolytics to stimulate autophagy and mitophagy and lower senescence ie must prune the bad mitochondria before stimulating them and stimulating growth of mitochondria. For this I use Rapamycin, Dasatinib, Fox04 DRI (MWF 0.5 - 1 mg for 4 months), and the Life Extension Senolytic Activator (twice a week for a couple of months).  Fasting also accomplishes this.  3.  Then stimulate mitochondria using:5 Amino 1 MQMots-C, SS-31, etcFree form amino acidsNMN4. Optimize Hormones incl HGH, Melatonin5.  Target Weight Loss, Insulin Resistance, Semaglutide 6.  Targeted peptides for each specific person's need including BioRegulators and many others...7.  Technology including PEMF, Nanovi. Red lights, etc. 8.  Exercise including HIIT https://www.drmorgancamp.com/about-dr-morgan-camphttps://www.drmorgancamp.com/ Want to try some peptides that Dr. Jen loves? Check out: https://integrativepeptides.com/drjen/  Thank you for watching please subscribe and share!  - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CHECK OUT a list of my Favorite products here:https://www.healthologybydrjen.com/drjenfavorites- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Dr. Morgan is an expert in Functional and Integrative Medicine with a Strong Emphasis in:Bio-Identical HormonesLongevity & Regenerative MedicineChronic InfectionsImmune-TherapyDetoxificationGI HealthStress-Related illnesses In addition to his 20 years of work in Functional Medicine, he has expanded his practice to include work on the deeper aspects of our being that point to the root cause of our illnesses working with Mind Body Wellness, Energy Medicine, and Healing with Consciousness. Dr. Morgan Practices in the Bay Area.  He loves hiking, swimming, meditating, working out, cooking, skiing & yoga.  He is passionate about the evolution of consciousness and the inter-relatedness of our health, our beliefs, and our state of mind. We will discuss:1.  Block Mtor1 and the production of senescent cells with rapamycinDr Alan Green 6 mg dosing. Dr Mogan uses between 2- 4 mg Weekly motr1 supressing, no immune suppression.2. Take senolytics to stimulate autophagy and mitophagy and lower senescence ie must prune the bad mitochondria before stimulating them and stimulating growth of mitochondria. For this I use Rapamycin, Dasatinib, Fox04 DRI (MWF 0.5 - 1 mg for 4 months), and the Life Extension Senolytic Activator (twice a week for a couple of months).  Fasting also accomplishes this. 3.  Then stimulate mitochondria using:5 Amino 1 MQMots-C, SS-31, etcFree form amino acidsNMN4. Optimize Hormones incl HGH, Melatonin5.  Target Weight Loss, Insulin Resistance, Semaglutide 6.  Targeted peptides for each specific person's need including BioRegulators and many others...7.  Technology including PEMF, Nanovi. Red lights, etc.8.  Exercise including HIIThttps://www.drmorgancamp.com/about-dr-morgan-camphttps://www.drmorgancamp.com/Want to try some peptides that Dr. Jen loves?Check out: https://integrativepeptides.com/drjen/Thank you for watching please subscribe and share! - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -CHECK OUT a list of my Favorite products here: https://www.healthologybydrjen.com/drjenfavorites- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

I embark on a fascinating journey into the realm of brain health, the wonders of senolytic supplements, and the intricate link between gut health and brain well-being. I'm joined by Dr. Nick Bitz, a distinguished member of the Neurohacker Collective team. The inception of Neurohacker Collective dates back to 2015, driven by an unwavering mission to craft unrivaled well-being solutions. Their approach to research and development is nothing short of groundbreaking, firmly rooted in the principles of complex systems science. And today is day 11 of my Biohacking Birthday Giveaway! You can enter my Birthday Giveaway here (prizes worth over $4,000)! Only two days left to enter!                We talk about: 12:40 - Supporting the body's self-regulation 21:10 - Factors contributing to nutrient deficiency and gut bacteria imbalance 23:00 - Running studies to make strong claims about product efficacy 25:50 - Contrasting regulation differences between skincare and dietary supplements 27:40 - Appreciating the alternative approaches in the biohacking world 30:10 - Short-term detox-like regimen for eliminating senescent cells 32:40 - Benefits of senolytic regimen for skin and overall health 37:20 - Autointoxication and its impact on the body 40:10 - Gut-brain axis and the power of psychobiotics 41:30 - Symbiotic: foundational product for gut health   Resources: Get my Hormone Balancing Chocolate recipe: Use ingredients that balance your hormones, support your menstrual cycle, preconception health and beyond. Check out my Ebb and Flow Cycle Guide that teaches you how to adapt your nutrition, exercise, supplements, lifestyle, biohacks and more to align with each of your menstrual cycle phases. Get Neurohacker products and use my discount BIOHACKINGBRITTANY Let's Connect: LINKS Ebb and Flow Cycle Guide Instagram TikTok Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, Google Podcasts  

We're thrilled to bring you this conversation with Hannah Went all about aging, biological clocks and epigenetics! She brings incredible insight into the options for testing your biological age, thoughts on telomere testing, the biggest drivers of aging, and what we can learn from the Dunedin pace of aging test. Tune in if you're interested in extending your healthspan! Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. During that time, she had multiple research internships studying cell signaling and cell biology. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation based age diagnostics and started TruDiagnostics in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers. TruDiagnostic has a commitment to research with over 30 approved clinical trials investigating the epigenetic methylation changes of longevity and health interventions. Since TruDiagnostic's inception, they have created one of the largest private epigenetic health databases in the world with over 15,000 patients tested to date. Hannah has since created Everything Epigenetics where she shares insights on how DNA regulation has an impact on your health.SHOW NOTES:0:51 Welcome to the show!1:45 Pop Quiz of the Day3:48 Non-Alcoholic Alternatives4:33 Kava & Kratom4:59 The emotional benefits of alcohol7:18 STUDY: Alcohol & Amygdala8:04 Hannah Went's Bio9:38 Welcome Hannah!10:38 How do Epigenetics affect Healthspan15:30 Steve Horvath & Biological Age17:24 Dr. Morgan Levine & 2nd Generation Clocks18:58 Is Telomere testing still valuable?22:04 Senolytics for Senescent Cells25:07 NEW STUDY: Predicting Age in Women28:30 Measuring Spermidine levels28:25 Epigenetic vs Blood/Serum Testing30:33 Spermidine, NMN, NR & Rapamycin33:55 Caloric Restriction & Dunedin PACE35:20 *Magnesium Breakthrough*37:30 The nuances of fasting/feeding39:28 Stress, thoughts & mindset on Aging40:20 3rd Generation Clock: Dunedin PACE44:35 The “Rejuvenation Olympics”45:50 Pregnancy, Illness & Surgeries47:01 How else can we slow the aging process?48:28 Effect of green space on aging50:04 How detrimental is alcohol?55:24 Sleep deprivation & age57:24 Transgenerational Epigenetic Inheritance59:52 Are we all doomed?1:02:35 How can we be more pro-active?1:03:22 Lab Grown Meat1:07:21 Her final piece of advice1:07:55 Where to find more of her!1:08:19 Thanks for tuning in!RESOURCES:Website: Everything EpigeneticsWebsite: TruDiagnosticIG: Everything Epigenetics Email: hannah@everythingepigenetics.comMagnesium Breakthrough - code: BIOHACKERBABES10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Dr. Felix Wong is a co-founder of Integrated Biosciences, an early-stage biotech company developing next-generation therapeutics for cellular rejuvenation. He is also a postdoc at MIT and the Broad Institute and was a lead author on a recent Nature Aging paper describing the use of graph neural networks to discover new senolytic compounds.In this episode, Felix and host Chris Patil have an in-depth discussion about using machine learning to accelerate drug discovery, specifically to target cellular senescence. They explore how graph neural networks were trained on screening data to evaluate large chemical spaces and identify new senolytic molecules with medicinal properties superior to those of previously known compounds.Key topics:What cellular senescence is and why selectively eliminating senescent cells may have therapeutic benefits for aging and age-related diseasesLimitations of traditional high-throughput screening approaches and the vastness of chemical spaceHow graph neural networks work and how Felix's team trained them on senolytic screening dataApplying the models to search much larger chemical libraries and identify promising new senolytic scaffoldsExperimental validation and characterization of hits from the AI screeningThe potential to use this machine learning approach more broadly for phenotypic drug discoveryFelix's new company Integrated Biosciences and their mission to control cellular stress responses using synthetic biology and AIQuotes:Quotes have been lightly edited for clarity."We found that machine learning models might allow us to more productively search chemical space and increase our working hit rates.""What was fascinating to us about senescence cells is that, unlike other pathologies or diseases, these cells are not really characterized by a single target.""The quality of any machine learning model is limited by the quality of the training data. And that in turn is limited by how good your screens are, and how good your understanding of the biology is."“That's really what machine learning is doing, trying to think about things in a very high dimensional manner. And then trying to build models that help to separate what is positive and what is negative.”“So what ideally we would want is for any model to be able to generalize, to be able to predict chemical scaffolds that the model has not previously seen, and positively identify those scaffolds as new senolytics.”"Ideally, we would like to treat aging and age-related diseases, just like how antibiotics treat bacterial infections."“At Integrated, we're trying to kind of look at these stress responses holistically. We think that senescence is only a piece of the bigger puzzle.”Links: Email questions, comments, and feedback to podcast@bioagelabs.comTranslating Aging on Twitter: @bioagepodcastBioAge Labs Website bioagelabs.comBioAge Labs Twitter @bioagelabsBioAge Labs LinkedInIntegrated Biosciences

EPISODE 122: Healthy cells equal a healthy body! Our body has around 37 trillion cells, making up every tissue, organ, and part of us.  However, like every living thing, cells age and eventually reach a state where they can no longer function normally. But they don't die. They enter a state called cellular senescence. While we are young, healthy, and vital, our immune system does a great job targeting these senescent cells, so they aren't an issue. But as we age and our immune system weakens, we start accumulating them, and they start affecting our bodily functions.  So, can we do anything to prevent aging at the cellular level and, consequently, aging in general? Yes, there is! And today's guest, Dr. Nick Bitz, knows all about it. He is a naturopathic doctor specializing in Ayurveda, anti-aging, dietary supplements, and cellular senescence. In my interview with Dr. Nick, we talk about the anti-aging powers of senolytics, dietary and lifestyle recommendations that target aging cells, and the connection between brain aging and senescent cells.  This insightful conversation has many great tips and information, so tune in!    Key Takeaways:   Intro (00:00) Cellular senescence (01:41) What are senolytics, and how do they target senescent cells? (08:22) Brain aging (11:13) Anabolic resistance and cellular senescence (14:00) Testing the effects of senolytics on humans and Dr. Nick's personal experiences (20:39) Protocols and different use cases of senolytics (23:26) Diet and lifestyle changes to prevent cellular aging (29:22) Senolytics and cancer (35:18) How Dr. Nick became an Ayurvedic doctor (37:30) On longevity and the future of health (48:53) Final thoughts and outro (55:07)   Additional Resources:   ➡️ Take the first step to a longer and healthier life: http://LLInsider.com/  ➡️ Coaching with Claudia: https://longevity-and-lifestyle.com/coaching  ➡️ Full list of resources, links, and show notes: https://longevity-and-lifestyle.com/podcast-122-dr-nick-bitz  ➡️ Special Offer for you dear audience: Get 15% off Qualia products at https://neurohacker.com/longevityandlifestyle - just use the code: longevityandlifestyle   Connect with Dr. Nick Bitz: ✨ Neurohacker Collective: https://neurohacker.com/  ✨ Instagram: https://www.instagram.com/neurohacker/  ✨ Facebook: https://www.facebook.com/neurohackercollective  ✨ YouTube: https://www.youtube.com/neurohacker   Follow Claudia on social media:  ✨ Facebook: https://www.facebook.com/claudiavonB  ✨ Instagram: https://www.instagram.com/longevityandlifestyle/  ✨ LinkedIn: https://www.linkedin.com/in/claudia-von-boeselager/  ✨ Twitter: https://twitter.com/longevitylifest  ✨ TikTok: https://www.tiktok.com/@longevityandlifestyle    Follow The Longevity & Lifestyle Podcast: ✨ Apple Podcasts: https://apple.co/3ogQDBd  ✨ Spotify: https://open.spotify.com/show/77XDkcNfzZCasJXL672h01    The Longevity & Lifestyle Podcast is dedicated to everyone who wants to increase their lifespan, improve their quality of life and unlock peak performance.   Don't forget to follow so you never miss an episode!  

Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body. Cellular senescence is the process by which cells permanently stop dividing but do not die off. These senescent cells linger inside the body and accumulate over time, affecting the healthy function of tissues and organs as we age.   I'm joined by Dr. Nick Bitz, and we're diving into everything you need to know about senescent cells and cellular senescence. We discuss why our bodies need some senescent cells, and some of the lifestyle changes we can make to support the body's ability to clear senescent cells. Plus, we answer the question: How young is too young to be worried about your senescent cells?    Dr. Nick Bitz is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. Thank you to our sponsors for making this episode possible: Add Neurohacker's Senolytic to your longevity routine by using code NATHALIE at neurohacker.com/nathalie  LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Nick Bitz: Website: https://neurohacker.com/ Instagram: https://www.instagram.com/neurohacker/ Facebook: https://www.facebook.com/neurohackercollective LinkedIn: https://www.linkedin.com/in/nick-bitz-283a03b/   What we discuss: [00:04:18] Why our bodies need some senescent cells  [00:11:34] How young is too young to be worried about your senescent cells?  [00:19:18] Lifestyle changes to support the body's ability to clear senescent cells  [00:30:43] Optimizing health throughout the entire body [00:40:53] Targeting different communities of senescent cells  [00:47:21] The importance of intermittent fasting Key Takeaways: 40 years old is the age where it is especially important to start taking steps to prevent senescent cells from accumulating in the body and causing age-related diseases, inflammation, weakened immune system, and cell damage.  Autophagy is the process by which cells break down and recycle their own components. Promoting autophagy can help reduce the formation of senescent cells, as it can help the body remove damaged cells and other debris that can accumulate and lead to cell senescence.  Senescent cells can accumulate in different tissues and organs, such as the skin, heart, and lungs, and can disrupt normal function. Therefore, it is important to address senescent cells in all tissues and organs to ensure optimal health.  

Dr. Gregory Kelly is the Director of Product Development at Neurohacker Collective, a naturopathic physician (N.D.), and the author of the book Shape Shift. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health. Additionally, he has develop several rare and powerful compounds that have scientifically shown senolytic activity. Get a MAJOR discount on all Neurohacker products (which are strong and really effective) Just USE CODE: OPP15 https://neurohacker.com/ Check out their synbiotic formula here: https://neurohacker.com/shop/qualia-synbiotic?rfsn=7332370.cc866f Sign up for What's Up Wednesday Newsletter HERE -  https://seanmccormick.com/ EPISODE SPONSORS - BioProtien+ - Boost HGH Naturally - Get $30 off here code OPP In this episode we cover: •Qualia Mind  •100 Day money back guarantee •How to decide which products are fit for the public •Why Dr. Gregory takes the weekend off from all supplements •How do you know if a smart drug is working •Senolytics and the removal of lingering dead cells •Sure, crush it at work during the day, but how are you when you get home? •Maybe nutrients would help you enjoy your family more.   

I see and talk to so many people who are unwell, and often I wonder if they had taken preventative strategies, would they be in this position today?  We don't educate enough about this, which is one of the main reasons I began my show...this episode is just incredible information for anyone over 40.  Or even younger for those real health enthusiasts. Today, I welcome Dr. Nick Bitz.  He is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements.In this episode we cover off...- A discussion on the aging process- What actually happens at a cellular level as we age- What are senescent cells- How these cells can contribute to diseases associated with aging- How can senolytics helpAnd so much more!I am absolutely a strong believer in what Neurohacker Collective is doing.  They back up everything they create with science and results.  I have a 15% discount for anyone who wishes to try their products using code SANDYK.  Shop here:  Neurohacker Collective.Be sure to SHARE this episode with someone who may benefit & subscribe, rate & review. And follow me below!Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgTwitter: https://twitter.com/sandyknutrition

Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body.Welcome to another episode of the Biohacking Beauty podcast brought to you by Young Goose Skincare! In this episode, host Amitay Eshel, the CEO of Young Goose, is joined by Dr. Nick Bitz, an expert in ayurvedic medicine, to discuss senescent cells and how to eliminate them for improved health and appearance. We also cover why the industry is evolving away from anti-aging to a wellness movement, and how the focus is on enhancing health rather than fighting disease.Dr. Nick Bitz is a naturopathic doctor who combines traditional and modern medicine in his practice. He has a Bachelor's degree in Biomedical Science from the University of Guelph and a Doctor of Naturopathic Medicine degree from Canadian College of Naturopathic Medicine. Dr. Bitz is passionate about helping his patients achieve optimal health and wellness using a holistic and individualized approach. He uses a variety of modalities including nutritional and lifestyle counseling, botanical medicine, acupuncture, and homeopathy. Dr. Bitz is particularly interested in brain health and optimization, and has developed a supplement line called Qualia to support cognitive function and overall wellness. What we discuss:[00:02] Understanding senescent cells and approaches to eliminate them to improve overall health and appearance.[07:19] Why the industry is evolving away from anti-aging and towards a wellness movement.[13:36] Why senescent cells are one of the hallmarks of aging.[19:30] Senescent cells are dead cells that infect surrounding cells, leading to disruption in the body.[25:39] Finding ways to eliminate senescent cells can improve body function and performance.[31:37] Synolytic compounds are effective in disrupting pro survival proteins and allowing cells to naturally prune away through apoptosis[37:43] Supporting autophagy through fasting or calorie restriction can help eliminate senescent cells.[43:56] Senolytics can lower inflammation load and stimulate body repair.[50:02] Pro C.A.R.E. Serum and C.A.R.E. Moisturizer contain senolytic compounds.Key Takeaways:Longevity is replacing the term anti-aging, and it is important to focus on healthspan rather than just looking younger.Senescent cells are one of the hallmarks of aging and can disrupt physiology throughout the body.Our Pro C.A.R.E. Serum and C.A.R.E. Moisturizer contain senolytic compounds to help clear senescent cells over time.To learn more about Young Goose:Website: https://www.younggoose.com/Instagram: @young_goose_skincareGet 20% off your first purchase by using code PODCAST20 at www.younggoose.comTo learn more about Dr. Nick Bitz:https://neurohacker.com/Instagram: @neurohackerTwitter: @theneurohacker

A new research paper was published in Aging (Aging-US) Volume 15, Issue 7, entitled, “Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.” The accumulation of senescent cells has an important role in the phenotypical changes observed in aging and in many age-related pathologies. Thus, the strategies designed to prevent these effects, collectively known as senotherapies, have a strong clinical potential. Senolytics are a type of senotherapy aimed at specifically eliminating senescent cells from tissues. Several small molecule compounds with senolytic properties have already been identified, but their specificity and range of action are variable. Because of this, potential novel senolytics are being actively investigated. Given the involvement of HDACs and the PI3K pathway in senescence, researchers Fares Al-Mansour, Abdullah Alraddadi, Buwei He, Anes Saleh, Marta Poblocka, Wael Alzahrani, Shaun Cowley, and Salvador Macip from the University of Leicester, Najran University and Universitat Oberta de Catalunya hypothesized that the dual inhibitor CUDC-907, a drug already in clinical trials for its antineoplastic effects, could have senolytic effects. “Here, we show that CUDC-907 was indeed able to selectively induce apoptosis in cells driven to senesce by p53 expression, but not when senescence happened in the absence of p53.” Consistent with this, CUDC-907 showed senolytic properties in different models of stress-induced senescence. Their results also indicate that the senolytic functions of CUDC-907 depend on the inhibitory effects of both HDACs and PI3K, which leads to an increase in p53 and a reduction in BH3 pro-survival proteins. Taken together, their results show that CUDC-907 has the potential to be a clinically relevant senolytic in pathological conditions in which stress-induced senescence is involved. “According to our results, CUDC-907 could be an interesting drug to be used as a senolytic, alone or as part of a targeted approach.” DOI: https://doi.org/10.18632/aging.204616 Corresponding author - Salvador Macip - sm460@le.ac.uk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204616 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, senolytics, HDAC, PI3K, CUDC-907 About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Have you ever heard of Senolytics?[i] It's the latest breakthrough in aging and longevity science that I honestly had not heard about until I had an email about our next guest, whose work I'm very familiar with. Watch this interview on YouTube here https://youtu.be/poThU96sslU   I'm a huge fan of Neurohacker Collective (that was founded in 2015 with a mission of creating best-in-class well-being products) and I've been following their work for years to learn anything and everything possible about bio-hacking. We even quoted Heather Sandison (a medical advisor and podcast host with Neurohacker Collective) on our HRV EPISODE. [ii] One quick look at their ABOUT US[iii] section on their website, and I saw many of the leaders, innovators in health, longevity and wellness around the world, and quite a few who we have interviewed, like Dr. Anna Lembke from EPISODE #162[iv], Dr. Stickler from EPISODE #96[v] and Dr. Vuyisich from EPISODE #93[vi] and in their Collective Insight Section you'll see many names we quote often, like Dr. Andrew Huberman, Deepak Chopra, Dale Bredesen, David Rabin, Bruce Lipton, Michael Gelb, Jim Kwik…I could go on and on here. These are the leaders and innovators in the field of health, wellness and bio-hacking. This is going to be a phenomenal episode! And with that, I want to welcome you back to The Neuroscience Meets Social and Emotional Learning Podcast, where we cover the science-based evidence behind social and emotional learning (for schools) and emotional intelligence training (in the workplace) with tools, ideas and strategies that we can all use for immediate results, with our brain in mind.  I'm Andrea Samadi, an author, and educator with a passion for learning specifically on the topics of health, wellbeing and productivity, and launched this podcast to share how important an understanding of our brain is to our everyday life and results using the most current brain research. If there's a tool, strategy or resource that I find, that could be helpful to improve productivity and results, whether we are a teacher in the classroom, a coach or in the modern workplace, I will share it here. On today's episode #285, we will be speaking with Dr. Gregory Kelly, the Director of Product Development at Neurohacker Collective[vii], a naturopathic physician (N.D.), and the author of the book Shape Shift: The Shape Intelligence Solution[viii] that's all about getting healthy while creating your ideal shape. As I was researching for this episode, I couldn't help thinking “how on the earth did I miss this topic of senolytics?” since I'm always looking for anything new when it comes to productivity, health and wellness hacks. While preparing for this episode, the Neurohacker Collective Team was extremely helpful. Tina Gammon, their Marketing Manager, sent me the trio package of Qualia Senolytic for (Vision, Night and Mind) and I'll be sharing the IMMEDIATE results I felt with the Night and Mind products, with a level of clarity I've never felt before.  I haven't tried the VISION one yet but have lots of questions to ask Dr. Kelly about today. So, hang tight, because on today's science-packed episode, we'll dive deep into this cutting edge topic, with the latest anti-aging research where we will cover: What is cellular senescence? What are the "Hallmarks of Aging" and why is cellular senescence an important hallmark? The difference between cellular senescence and autophagy (with a quick review of 9th grade science mitosis). Classical places where senescent cells take hold in the body. The science to support senolytics from Mayo Clinic and Scripps Institute. How do senolytics work? The correct way to dose senolytics. What makes Qualia Senolytic a groundbreaking supplement in the longevity space? A bit first about Dr. Kelly.   He has extensive experience in both natural medicine and nutrition, and has been an influential figure in this field. He has served as the editor of the journal Alternative Medicine Review and taught Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships at the University of Bridgeport College of Naturopathic Medicine. Dr. Kelly has also published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has over 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health. Additionally, he has helped develop several rare and powerful compounds that have scientifically shown senolytic activity, and which have a wider range of mechanisms than existing senolytic supplements available. Before I get lost in my words on this topic, let's meet Dr. Gregory Kelly, and see what we can learn today to open our eyes to something new in this ever-changing field of science, health and longevity. Welcome Dr. Kelly. Thank you for being here on a Friday night. I'm curious with your background, what would you typically be doing on a Friday night (I imagine hanging out with Dr. Stickler and perhaps Dr. Andrew Huberman) talking about what you can create with the latest neuroscience research. Dr. Huberman advising you on your vision products, and Dr. Stickler, with a stack of tools for peak performance to investigate…is this what a typical Friday night would look like for you? INTRO Q: Dr. Kelly, I watched your interview with Dave Asprey, because he's been promoting your new Qualia product that we will be talking about today, all over the place, so I had to see what he asked you when he interviewed you (because he's such a creative mind).  I loved how he asked you about why you called your company Neurohacker Collective! What a great question. Can you share the answer again for our audience, as it's fitting for our podcast? Q1: Can we start with the basics?  What is cellular senescence and can you explain it from the 2 angles-the Zombie explanation for the movie experts who tune into the podcast vs the gardener analogy? 1B: How do we know we have senescent cells? Is it like inflammation? Q1C: We've talked about the concept of using exercise to prevent the shortening of telomeres on this podcast, but can you orient us with this idea and how it came into the evolution of aging? Q2: Our podcast took a turn towards health and wellness during the pandemic and we picked 5 health staples to dive deep into. You can see a couple of people from your organization that we've had on the podcast and many others we quote. Can you look at the list I've chosen, and tell me what I'm missing if we were to compare them to the "Hallmarks of Aging?" that you've uncovered? Q3: What's the difference between cellular senescence and autophagy (with a quick review of 9th grade science/mitosis here) and what we should expect healthy cells to do in our body vs the ones that give us trouble? Q4: What are some places where senescent cells take hold in the body? What about the science that supports senolytics from Mayo Clinic and Scripps Institute? What should we know? How do senolytics work? Q5: Andrea's vitamin story-I've got to also ask about the difference between taking vitamins that remove free radicals. It's not easy to see what's going on in the body. How would this be similar/different? Q6: What's the correct way to dose senolytics?  I loved that Dave Asprey was looking for a way to bio-hack what you've invented and perhaps take senolytics once a decade of something. Will this ever be a possibility? Q7:  I've got to give a huge shout out to Tina Gammon, on your Marketing Team, as she made sure I was sent all 3 of your Qualia Senolytics (for Vision, Night and Mind). I tried the NIGHT one for optimized sleep, and now I'm someone who measures everything and sleep is one of my weakest links, but I had the craziest, most vivid dreams and definitely felt recharged when I woke up. I took the MIND one before my day began, and I'm someone who also logs my levels of CLARITY on a weekly basis (Brendon Burchard would like this done daily) but I did notice an usual surge of clarity. Is this something you've heard of before? Is it usual to notice something like I did the VERY next day? What do most people notice? What about the VISION one? Did you consult with Dr. Huberman with his expertise here on Ophthalmology? I wear contacts and am finally ready for laser eye surgery…should I hold off on using this one till I finish messing around with my eyesight? Q8: What makes Qualia Senolytic a groundbreaking supplement in the longevity space? Q9: As we wrap up and close out this episode, what's one thing that you hope our listeners will take away from this episode on your work over the years, senolytic cells, Neurohacker Collective, and what we can do to optimize our health and longevity at the cellular level? Thank you, Dr. Kelly, for coming on the podcast. I was so excited to meet you, dive deeper into this topic and think about how I'm going to implement this ground-breaking product into my day.  For people who want to try your Qualia Senolytics, I was thrilled to see that your team created an affiliate link and coupon code for our audience:    CLICK ON THE LINK IF YOU WOULD LIKE TO TRY QUALIA SENOLYTICS https://neurohacker.com/shop/qualia-senolytic?rfsn=7305328.843217 Code: NEUROSCIENCE (good for 15% off purchase). Is there one product that you recommend plain Qualia Senolytic vs the specific versions I have for VISION, MIND and NIGHT? Thank you again for your time on a Friday night. RESOURCES: Senolytics improve physical function and increase lifespan in old age Published July 9, 2018 by Ming Xu et al. https://www.nature.com/articles/s41591-018-0092-9 X3 Bar by Jaquish https://www.jaquishbiomedical.com/ Studies on the Qualia Products https://neurohacker.com/studies The Hallmarks of Aging by Carlos Lopez-Otin et al Published June 6, 2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ The 12 Hallmarks of Aging Published Jan. 2023 by Carlos Lopez-Otin et al https://pubmed.ncbi.nlm.nih.gov/36599349/#:~:text=We%20propose%20the%20following%20twelve,exhaustion%2C%20altered%20intercellular%20communication%2C%20chronic To stay young kill zombie cells Published Oct. 26, 2017 by Megan Scudellari https://www.nature.com/articles/550448a Cell Fates- Division, Senescence and Death by Armando Hasudungan on YouTube https://www.youtube.com/watch?v=Egy--doiBF0 Telomeres and Cell Senescence Khan Academy https://www.youtube.com/watch?v=R5YiO6rKr-w (Phenomenal Explanation)! REFERENCES: [i] Senolytics: The Latest Breakthrough in Aging and Longevity Science bu Nickl Bitz https://neurohacker.com/senolytics-the-latest-breakthrough-in-aging-and-longevity-science-an-interview-with-the-neurohacker-science-team [ii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE #125 on Heart Rate Variability: Why It's Important for Tracking Health, Recovery and Resilience  https://andreasamadi.podbean.com/e/what-is-hrv-and-why-is-it-important-for-tracking-health-recovery-and-resilience-with-andrea-samadi/ [iii] https://neurohacker.com/about [iv]Neuroscience Meets Social and Emotional Learning Podcast EPISODE #162 with Dr. Anna Lembke on “Dopamine Nation: Finding Balance in the Age of Indulgence”  https://andreasamadi.podbean.com/e/medical-director-of-addictive-medicine-at-stanford-university-dr-anna-lembke-on-dopamine-nation-finding-balance-in-the-age-of-indulgence/ [v] Neuroscience Meets Social and Emotional Learning Podcast EPISODE #96 with Dr. Stickler on Expanding Awareness for Limitless Peak Performance, Health, Longevity and Intelligence  https://andreasamadi.podbean.com/e/dr-daniel-stickler-on-expanding-awareness-for-limitless-peak-performance-health-longevity-and-intelligence/ [vi]Neuroscience Meets Social and Emotional Learning Podcast EPISODE #93 with Dr. Momo Vuyisich on Improving the Health of Your Microbiome Preventing and Reversing Chronic Disease  https://andreasamadi.podbean.com/e/dr-momo-vuyisich-on-improving-the-health-of-your-microbiome-preventing-and-reversing-chronic-disease/ [vii] Neurohacker Collective https://neurohacker.com/ [viii]Shape Shift: The Shape Intelligence Solution by Dr. Gregory Kelly   https://www.amazon.com/Shape-Shift-Intelligence-Solution-ebook/dp/B0711S1JSC  

Senolytics are a science field with the potential to revolutionize human aging. In 2016, two of the top medical research institutions in the country- The Mayo Clinic, and Scripps- published some pretty astounding research. They identified ingredients that help our bodies naturally eliminate senescent cells! And in the years since, many other studies have demonstrated the power of these little-known ingredients. Meanwhile at Neurohacker, the research we were doing for healthy aging products - Qualia Life and Qualia Skin - led us to the emerging research on cellular senescence. Our team of scientists and doctors for years evaluated senolytic ingredients - ranking each according to its efficacy and mechanism of action. In this episode we sat down with two members of the Neurohacker Science Team - Dr. Greg Kelly and Dr. Nick Bitz with the goal of sharing everything we have learned along the way. The message is clear: the research surrounding senolytics is absolutely worth paying attention to. And today, we're here to break down the science for you.

Everyone wants to slow down the signs of aging, but very few people are going about it the right way. The negative aspects of aging are one of the most ubiquitous challenges to quality of life. However, one thing is for sure: scientists believe that a big part of the reason we experience aging the way we do is because of stressed or worn-out cells called senescent cells. Senolytics is a term used to describe ingredients shown to help decrease these damaging senescent cells.  My guest on this show - Gregory Kelly - has helped to develop several rare and powerful compounds that have scientifically shown senolytic activity, and which collectively cover a broader range of mechanisms than existing senolytic supplements on the market. His protocol, which we discuss on this show, involves a two-day rejuvenation regimen that he suggests using every month. Intermittent short-duration dosing is the most common way that senolytics are used in studies, and data suggests that it can take weeks for senescent cells to re-accumulate in the body, which is why Greg recommends this approach. Greg's compound is called "Senolytic" and made by my friends at Neurohacker Collective. For the full episode page and shownotes, visit: https://bengreenfieldlife.com/senolytic Episode sponsors: Organifi (Red): Recharge your mind and body with a delicious superfood berry blend of premium, organic superfoods that contain potent adaptogens, antioxidants, and a clinical dose of cordyceps. Increase energy and boost nitric oxide levels with zero caffeine and only 2 grams of sugar. Go to organifi.com/Ben for 20% off your order. Seed: If you're taking supplements, but not a probiotic, you might be overlooking your gut—which affects your whole-body health. If you want to add a probiotic + prebiotic to your daily routine, use code BEN15 at seed.com/ben to redeem 15% off your first month of Seed's Daily Synbiotic. Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go Joovv.com/ben and apply code BEN. Element Health CBD: Full-spectrum CBD and by far the most potent stuff on the market. If you're dealing with sleeping problems, anxiety, or stress, you got to try it. It's been a game changer for me. Go to elementhealthsupply.com/ben and use code BEN15 for 15% off your entire order. Boundless Parenting Book: Everything you need to know about family, parenting, and raising healthy, resilient, free-thinking and impactful children. Go to boundlessparentingbook.com and pre-order your copy now. BGL CAREERS: Check out our open positions at BenGreenfieldLife.com/Careers. Shine Sedona: Join my family and me in Sedona Arizona from March 10-12, 2023 at an amazing event hosted by SHINE. I'll be giving a keynote talk on breathwork and biohacking, and hosting a VIP Greenfield-style home-cooked dinner prepared by my family. For tickets to the Shine Event where I'll be a keynote speaker visit bengreenfieldlife.com/shinesedona.  To book your spot for our VIP dinner visit bengreenfieldspeaking.com/sedona-dinner.   

The inimitable 7Song reviews all the important items in his (very large) first aid bag. This talk features some of the most important plant medicines and other items to have around the house and how to treat common home first aid situations such as colds and flu, cuts, injuries and pain. June 2 – 4, 2023: Medicines from the Earth Herb Symposium – In person in Asheville, NC LEARN MORE AND REGISTER 24 clinical botanical medicine presentations including: Using Medicinal Mushrooms Synergistically with Botanicals Senescence, Senolytics and Aging Peru's Sacred Plant Boom and Sustainability We are Stardust: Trace Elements as Building Blocks of Health Parallels between the TCM Principle of Essence and Modern Genetics: From Analog to Digital Case Studies in the Naturopathic Management of Neurodegenerative Conditions Mast Cells: Their Role in Health and Disease and Botanical Affectors Pre-Symposium Intensives with Jillian Stansbury, ND and Jason Miller, DACM, LAc Plus medicine-making classes and herb walks. Early bird registration dates February 22 and April 6. Continuing Education available. Information: www.botanicalmedicine.org (541) 482-3016. A huge thanks to the Medicines from the Earth Symposium for sharing the audio for today's episode! Learn more about 7Song at 7Song.com Thanks for listening!  HerbRally www.herbrally.com  Want to show your support for the HerbRally Podcast? Consider becoming an HerbRally Schoolhouse member. You receive access to exlclusive classes, discounts and more. It's only $10/month! Get your first 30 days FREE with coupon code PODCAST at checkout.  A huge thanks and shoutout to our 200+ members!  LEARN MORE AND REGISTER

Dr. Peter Michalos - Wonder drugs for aging. Senolytics. by John Catsimatidis

IN THIS EPISODE OF THE HUMAN UPGRADE™… you'll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that's still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It's the quality of your close relationships that matters.Good close relationships don't just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You'll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don't be dragged down.)what social fitness is and how to practice it. (Yes, it's a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)Watch this episode on YouTube!Don't Miss This! Dr. Waldinger's TEDtalk about the study is one of TED's Top 10 episodes and viewed more than 43 million times.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Energize Your Brain & Body: https://nootopia.com/davegenius, use code DAVE10 to get an extra 10% offClear Out Zombie Cells with Senolytics: https://neurohacker.com/dave, code ASPREY to get an additional 15% off9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You'll learn from dozens of experts at an amazing event that's designed to upgrade every area of your life.https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neurohacker Collective sponsored this episode.IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADE™… you're going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he's director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee. Watch this episode on YouTube!9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You'll learn from dozens of experts at an amazing event that's designed to upgrade every area of your life. https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™…… Steven Gundry, M.D., explains that ketones aren't the fat-burning molecules you think they are. Ketones actually work to enhance health, weight loss, and longevity by acting as signaling molecules that stimulate your mitochondria. A cellular process known as “mitochondrial uncoupling” happens. He debunks common myths about keto in his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,” and shares eight “keys” that unlock the keto code: Intermittent fasting or time-controlled eating PolyphenolsDietary fiber Fermented foods PolyaminesCold temperaturesHot temperaturesRed light therapyUpgrading your nutrition with keto gets even simpler in this conversation that gives you real food examples of how to ignite your mitochondrial uncoupling process without a monotonous, limiting, high-fat diet.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get 30% off products at https://gundrymd.com. Use code DAVE30 at checkout.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Clean up Zombie Cells with Senolytics: https://neurohacker.com/dave, use code Asprey15 to save 15%Cooler Temps for Deeper Sleep: https://www.chilisleep.com/, use code HUMANUPGRADE20 to save 20% on the Dock Pro Sleep System. Learn more: Upgrade Spotlight: Improve Your Sleep With a Cooler Body Temp – ChiliSleep – #923Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ja, af en toe komt er iets nieuws. Of het groot gaat worden, dat weet je pas over vijf jaar. Creatine begon 20 jaar geleden ook als een obscuur en heel duur ingredient. Senolytics zijn stoffen die zogenaamde slapende cellen, of zombie cellen dood maken. Voordat je denkt dat je je aan het beschermen bent tegen de apocalyps, dit is een serieuze wetenschap, met serieuze implicaties voor je gezondheid. En voor alle biohacks en zeker anti-aging geldt, je kan er maar beter vroeg genoeg bij zijn. It's time to talk!  Mogelijk gemaakt door NoordCode. Functionele voeding van de hoogste kwaliteit. Gemaakt voor en door biohackers.  Gesourced in europa. www.noordcode.com    Benieuwd naar het meest complete biohacking programma op de markt? Met de tools en technieken van topsporters en business professionals? 12 weken lang meten we je DNA, darmen, bloed en nog veel meer door. Neem een kijkje hoe we jou fysiek en mentaal kunnen verbeteren. www.humanupgrade.nl   Instagram: @govert4giver  @eduarddewilde 

Greg Kelly is a Naturopathic Doctor (N.D.) and Director of Product Development at Qualia, a company whose mission is to create best in class well-being products based on their unique scientific approach to research and development. In this episode, Drew and Greg chat about the power of nootropics, the best ways to change body composition without damaging your metabolism, and the exciting science and innovation taking place around combating aging!   HIGHLIGHTS:   [04:33] Greg explains the history of nootropics, and delves into the story of his book, Shape Shift: The Shape Intelligence Solution.   [17:08] The dangers of dieting in a caloric deficit long-term, and the best ways to change your body composition without damaging your body.   [24:20] The two main theories behind why we age, the exciting discoveries and innovations that are taking place around aging, and the science behind Senolytics.    [40:01] The many functions of Senolytics, and what you can expect from taking them based on your particular circumstances.   SPONSORS:   Qualia — Qualia's mission is to create best in class well-being products by employing a unique methodology of research and development based on complex systems science. Their flagship product, Qualia Mind, is an industry leading nootropic that promotes mental clarity, sharpened focus, stress resilience, boosted energy, and much more! Click HERE to receive $100 off of your order, and use code “fit2fat2fit” to receive an extra 15% off of your order at checkout.   Dry Farm Wines — You can have alcohol on the ketogenic diet. Use this link for a bottle of wine for $.01 with any order.   SHOW LINKS:   Senolytics Study Take the Fit2Fat2Fit Podcast Listener Survey Fit2Fat2Fit on Facebook  @Fit2Fat2Fit on Instagram Fit2Fat2Fit Book  Keto School Program Complete Keto Book Email Drew: info@fit2fat2fit.com

In individuals with Down syndrome, there is an aging-like phenotype known as senescence. Hiruy Meharena, Ph.D., UC San Diego, discusses how this impacts neurodevelopment. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38388]

In individuals with Down syndrome, there is an aging-like phenotype known as senescence. Hiruy Meharena, Ph.D., UC San Diego, discusses how this impacts neurodevelopment. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38388]

In individuals with Down syndrome, there is an aging-like phenotype known as senescence. Hiruy Meharena, Ph.D., UC San Diego, discusses how this impacts neurodevelopment. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38388]

In individuals with Down syndrome, there is an aging-like phenotype known as senescence. Hiruy Meharena, Ph.D., UC San Diego, discusses how this impacts neurodevelopment. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38388]

In individuals with Down syndrome, there is an aging-like phenotype known as senescence. Hiruy Meharena, Ph.D., UC San Diego, discusses how this impacts neurodevelopment. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38388]

Today I discuss some exciting anti-ageing research. Here is a link to the paper:  https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00096-2/fulltextSee omnystudio.com/listener for privacy information.

Joining us today to explore cellular senescence, senolytics, bone loss and osteoporosis is Dr. Nick Bitz, ND.=>>FREE Stronger Bones Masterclass (Gain Access Now!)=>>FREE 7-Day Osteoporosis Kickstart***Topics Covered0:00 - Episode start3:05 - How Dr. Nick Bitz got into this field6:44 - What does an Ayurvedic approach to bone health look like?13:47 - You're a trained naturopathic physician and have a unique perspective on bone health… What does the naturopathic approach to bone health look like?17:01 - What is cellular senescence and how is it different from autophagy? What effect do senescent cells have on bone?21:34 - What are senolytics and any studies on senolytics and bone loss, bone health, and osteoporosis?25:00 - What human studies exist in this area?26:04 - What are some of the most interesting findings so far with senolytics?30:35 - How do people feel when senescent cells are being cleared out of the body?32:50 - Is there a connection between brain aging and senescent cells?35:05 - How does the immune system factor in with this?37:34 - How is anabolic resistance connected to senescent cells?39:04 - Are there any diet and lifestyle behaviors you'd recommend related to senescent cells?40:47 - Biggest takeaways for listeners of this episode42:53 - Where can people find you?***Resources MentionedFind all resources mentioned and show notes @=>>https://bonecoach.com/neurohacker-collective-senolytics-osteoporosis***What can you do to support your bone health and this podcast?1. Hit the “Subscribe” Button. 2. Leave a review. Thank you!

Lauren Alexander from Neurohacker Collective joined our podcast to discuss the science behind senolytics and how senescent cells play a role in aging. She shares how these "zombie cells" impact our immune system, joint health, cancer and longevity. We also discuss the best way to supplement with senolytics and why the "hit and run" strategy is so effective.Lauren Alexander is VP of Marketing at Neurohacker Collective, a company focused on making wellness products best known for their Qualia Mind supplement. Lauren is the mother of two young children, a passionate gardener and biohacker. Her areas of expertise include nootropics, biohacking, anti-aging, sleep and neurohacking.SHOW NOTES:0:51 Welcome to the show!3:15 Lauren Alexander's Bio4:05 Welcome Lauren to the podcast5:05 What is ‘cellular senescence'?8:52 Zombie cells10:41 Who is at risk of cellular aging?13:14 *Felix Gray Ad*16:57 Signs of a robust immune system18:10 STUDY: Qualia & Joint Pain19:23 Re-examining how we look at aging19:58 Senescent cells & Cancer21:09 Symptoms & signs to look out for22:55 Ingredients & Protocol in Qualia Senolytic28:40 Bioavailability and safety of supplements32:11 *SilverBiotics Ad*35:20 Should children use Senolytic?37:41 The hormetic effect of “hit and run”38:44 Biological Age Testing43:24 Should anyone not be taking it?43:59 Dosage & Frequency of supplementation44:36 Origin of the word ‘senolytic'45:30 Client benefits48:52 What about Fisetin?51:03 Her final piece of advice54:45 Renee's #1 Sleep Hack56:02 Lauren's #1 Sleep Hack57:28 Where to learn more about Neurohacker57:50 Thanks for tuning in!RESOURCES: Neurohacker.comShop: Qualia Senolytic - Save 15% with code BIOHACKERBABESIG: Neurohacker CollectivePilot StudyFelix Gray GlassesSilverBiotics - Discount code: BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

Episode Highlights With Dr. Nick BitzWhat to understand about aging and the multiple theories of what contributesWhy aging might be a slowed ability to adaptThe three main theories of aging and how understanding them can help you slow itWhat to look at and test as a baseline to determine agingWhat the nine hallmarks of aging are: telomeres, DNA mutations, epigenetic changes, senescent cells, etcCellular senescence: the process by which cells ageCompounds that can help improve the body's ability to deal with senescent cellsHealthspan vs lifespanHow fasting comes into play with aging and senescent cellsWhy exercise battles all aspects of aging (especially strength training)How early morning sunlight impacts hormones, sleep, and agingInteresting research around chlorophyll and agingThe importance of leucine and how to get itThings we are doing that are speeding aging (some might surprise you)What senolytics are and how to dose them (Quercetin, Fisitin, etc)Why senolytics in large doses every couple of months can be beneficialResources We MentionNeurohackerCan Intermittent Fasting (Skipping Meals) Make You Healthier?The Power of Now: A Guide to Spiritual Enlightenment by Eckhart TolleGrace and Grit: Spirituality and Healing in the Life and Death of Treya Killam Wilber by Ken Wilber

This episode of the Biohacking Beauty podcast is the biohackers guide to skin aging and senescent cells. Amitay Eshel, co-founder and CEO of Young Goose, discusses what senescent cells are. He also touches on extrinsic and intrinsic drivers of senescent cell accumulation and what happens if we have an accumulation of it. Lastly, Amitay talks about senolytics and how it can help eliminate senescent cells. What Amitay discusses:  0:00 - Intro 3:19 - What are senescent cells? 5:11 - Correlation of senescent cells and the appearance of the skin 6:48 - Extrinsic and intrinsic drivers of senescent cells accumulation 14:44 - What happens if we have an accumulation of senescent cells? 15:38 - The relationship of skin stress and our brain function 16:06 - How can we delay whole body aging?  16:28 - What are senolytics? 17:13 - How to induce senolytic effect? 19:46 - What happens if the skin barrier ages?  Find more from Young Goose: Website: https://www.younggoose.com/ (https://www.younggoose.com/) Instagram: https://www.instagram.com/young_goose_skincare/ (@young_goose_skincare)  Get 20% off your first purchase by using code PODCAST20 at www.younggoose.com

There are many research-backed ways to increase quality of life and slow or prevent age-related diseases. In this episode, Dr. Greg Kelly–naturopathic physician and author of Shape Shift–expands on senolytics, a class of drugs that show positive effects on aging, brain and skin health, and anabolic resistance. Hear how senolytics, along with strength and resistance training, walking, perfecting your circadian rhythm, and consuming protein, can help you age and feel well. https://www.drruscio.com/reducing-aging-and-increasing-quality-of-life-with-senolytics  My book Healthy Gut, Healthy You is available at https://drruscio.com/getgutbook  If you're in need of clinical support, please visit https://ruscioinstitute.com  Looking for more? Check out https://drruscio.com/resources 

SHR # 2919:: STUDY: COVID-19 and Chronological Aging: Senolytics and Other Anti-aging Drugs for the Treatment or Prevention of Coronavirus Infection? - Dr. Michael Lisanti, MD - PhD - Many of us in this audience already use senolytic agents to help push back biological aging. Are these strategies helpful in protecting against COVID-19 as well? Is there a difference in the death toll of those who are chronological 0ver 60 years old versus a 65 year old person who is biologically 40? And what of time restricted feeding? It imparts some of the same benefits as senolytics. We learn the answers to these and more on today's show. study link: https://www.aging-us.com/article/103001/text

Dr. Nick Bitz from Neuro Hackers shares his insight on Senolytics, a revolutionary compound that targets aging cells in our bodies. Aging is a natural part of life but there are many things we can do today that will help us age gracefully. In addition to Senolytics, Nick explains how  Ayurvedic medicine will help you identify your body's individual needs and create a personalized guide to help you rejuvenate your body, which is in essence anti aging.    Key Takeaways: [0:20] The 9 hallmarks of aging [2:40] Senolytics: targeting our aging cells [5:30] Studies show senolytics are best taken in larger doses instead of daily [6:45] Senolytics compounds have the potential to cross the blood brain barrier [8:40]  What you can do to support Senolytic compounds: exercise, fasting, Immune Support [11:20] Building resilience: sleep, personalize an energetic diet, adaptogens  [12:40] Ayurvedic Medicine: The science of living and matching your lifestyle to your body type [17:00] Rejuvenation: Restoring the water element to your body [18:46] Abhyanga: Daily self massage with the right oil for your skin.   Mentioned in the Episode: https://neurohacker.com/   Twitter: “It's better to consume multiple senolytics at once, rather than just a single agent, just to make sure that you're giving your body the greatest chance of eliminating these senescent cells.”  [4:44]   “Sleep that's critically important to building resilience. If you're not sleeping adequately, you can't maintain resilience in any kind of significant way. [11:36]   “It's all about rejuvenation which is in essence anti aging.” [17:18]

Jerry Hickey, Ph dives into research about the importance of Quercetin and how the supplement helps the Anti-Aging process. Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here

News: This new neural sleeve helps people overcome mobility challenges | ZDNet (01:08) A new mobility sleeve under development and out of stealth promises a compelling solution for those suffering a variety of mobility issues.Monitor and stimulate the neuromuscular system Lightweight next-gen mobility devices The technology was invented by Jeremiah Robison, a Silicon Valley serial entrepreneur, following his daughter's cerebral palsy diagnosis.Inspired by two of his daughter's clinical experiences. The first inspiration was a complex data capture session at a gait lab using optical and EMG sensors, which recorded precise information about her walk.Electromyography sensors, also known as EMG sensors, measure small electromyographic signals generated by your muscles as you move them.  The second inspiration was functional electrical stimulation as part of her physical therapy.Electrode pads were placed on individual muscle groups, which a therapist stimulated during walking sessions to stimulate and strengthen the muscles. The device & company that was created is called CIONICThe device is a wearable for people with mobility issues that doesn't just monitor leg movements but actually helps activate the person's muscles. CIONIC partnered with the Laboratory for Engineering of the Neuromuscular System (LISiN) at The Polytechnic University of Turin. Robison talked on the device:“We set out to create a product that combined the diagnostic power of a multi-million dollar gait lab with the therapeutic power of Functional Electrical Stimulation (FES) … We were confident we could leverage the recent technological advances enabling innovative products like self-driving cars and apply it to the human body to solve an enormous problem: 14% of adults in the US experience mobility impairment, a number expected to balloon to 20% by 2050."  The resulting sensor array successfully combines electromyography (EMG) and functional electrical stimulation (FES).LISiN Lab helped develop a comprehensive risk assessment strategy to ensure that the product was effective and safe Meta open sources early-stage AI translation tool that works across 200 languages | The Verge (08:37)  Social media conglomerate Meta has created a single AI model capable of translating across 200 different languagesThe company is open-sourcing the project in the hopes that others will build on its work. The AI model is part of an ambitious R&D project by Meta to create a so-called “universal speech translator,” which the company sees as important for growth across its many platforms Machine translation allows Meta to better understand its users (and so improve the advertising systems that generate 97 percent of its revenue)Could also be the foundation of a killer app for future projects like its augmented reality glasses. While most machine translation models handle only a handful of languages, Meta's model is all-encapsulating: it's a single system able to translate in more than 40,000 different directions between 200 different languages. Meta AI research scientist Angela Fan, who worked on the project, says the model, described in a research paper here, is already being tested to support a project that helps Wikipedia editors translate articles into other languages. Additionally, Fan stated that an important decision was to open-source as many elements of the project as possible — from the model to the evaluation dataset and training code. Meta also offers grants to researchers who want to contribute to such translation projects but are unable to finance their own projects We are going to end off with a quote from Fan:“I think that's really, really important, because it's not like one company will be able to holistically solve the problem of machine translation … It's everyone — globally — and so we're really interested in supporting these types of community efforts.”   Tiny shapeshifting robots brush and floss your teeth, kill bacteria | New Atlas (14:53) Engineers at the University of Pennsylvania have developed a system of microrobots that can change shape to form bristles or floss. They don't just brush plaque away, but release antimicrobials to kill bad bacteria. If you want to outsource brushing your teeth to robots. Part of the problem with teeth brushing is that toothbrushes don't account for differences in the shape or spacing of different people's teeth.The new system solves that issue by effectively shapeshifting. It's made up of iron oxide nanoparticles, which can be assembled into different formations and controlled using magnetic fields. The particles can be arranged into the shape of bristles to brush plaque from tooth surfaces, or thinner floss-like strands to scrub between teeth. Iron oxide is known to activate hydrogen peroxide, triggering a reaction that produces free radicals that kill bacteria and the sticky biofilms they form on teeth. The system was tested on a flat slab of artificial tooth-like material, then a 3D-printed tooth model, and finally on real human teeth. The tests showed that these microrobots could efficiently remove plaque and biofilms, reducing pathogenic bacteria below detectable levels. Also showed they could precisely control the bristle stiffness and length by adjusting the magnetic field.This allowed the tips to be made firm enough to clean the teeth but still soft enough to be gentle on gums. The researchers say that the customizability of this microrobot system could clean people's teeth better, while its hands-free potential could allow people with reduced fine motor skills to still take care of their oral health. New drug increases human life span by 30%, according to Mayo Clinic | Brighter Side News (19:47) Scientists may never find the elixir of life, but they are finding new ways to extend our life spans. Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that may protect older people against aspects of aging and a range of diseases. Senolytics developed at Mayo Clinic and given once clear the bloodstream of senescent or "zombie" cells.These cells contribute to multiple diseases and negative aspects of aging. Diseases including atherosclerosis (a form of heart disease), diabetes, and lung disease. As you age, these zombies build up in the body. They can make it difficult for your body to repair tissue, and they can release chemicals that harm normal cells nearby. This study shows that the removal of senescent cells significantly boosts the production of a protective protein called a-klotho.The protein a-klotho is important to maintaining good health, as it tends to decrease with age, and especially decreases in multiple diseases, including Alzheimer's, diabetes and kidney disease.  James Kirkland, M.D., Ph.D., a Mayo Clinic internist and senior author of the study., talked on these Senolytics drugs:“We show that there is an avenue for an orally active, small-molecule approach to increase this beneficial protein and also to amplify the action of senolytic drugs." Animal studies have shown that decreasing a-klotho in mice shortens life span and increasing a-klotho in mice by inserting a gene that causes its production increases life span by 30%. This study shows that senolytics increased a-klotho in humans with idiopathic pulmonary fibrosis, a senescence-associated disease that leads to frailty, serious breathing difficulties and death.   Tesla will open up Superchargers to non-Tesla electric vehicles in the US later this year - The Verge (24:23) Tesla plans to open up its Supercharger network to non-Tesla electric vehicles in the US in late 2022, according to a White House memo. The company has been allowing non-Tesla EVs to use its Supercharger plugs in several cities in Europe as part of a limited pilot program but has been quiet about when US charging stations would be available to non-Tesla EV owners.  The memo stated: “Later this year, Tesla will begin production of new Supercharger equipment that will enable non-Tesla EV drivers in North America to use Tesla Superchargers.” Tesla did not respond to an email seeking confirmation of these plans (Elon Musk disbanded the company's PR office in 2019). It's not clear whether the White House purposefully scooped Tesla's own announcement on this project. Tesla's Supercharger network is often held up as the best possible example of an EV charging network: fast, reliable, and plentiful.  This news is in line with what Tesla's CEO Elon Musk has, for years, about opening up his Superchargers to other companies' electric vehicles.  If the US version of the pilot program works the same as it does in Europe, non-Tesla EV owners will need to download the most recent version of Tesla's smartphone app in order to access the stations. They will be prompted to select “Charge Your Non-Tesla” in order to find the closest participating Supercharger site.  Tesla owners can still use the stations just as normal. 

Have you ever wondered why your efforts seem to come up short? Have you felt like there is another level of energy you just can't seem to achieve? It could very well be senescent cells, these zombie cells that are bad influences on healthy cells that have worn out their welcome! In this episode I have the amazing Lauren Alexander from Neurohacker Collective with me dropping knowledge about cellular health, mental resilience and brain and sleep optimization. Don't sleep on this one! (see what I did there?:) Check out ALL the great info and more at Neurohacker Collective! Use this link to order and Save an additional 15% code: WENDI https://neurohacker.com/shop/qualia-senolytic?rfsn=4125870.bea9731

In this video Professor Robbins discusses the process by which his and other labs look for possible senolytics. He also talks about fisetin and why he chooses to take it Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

This week's episode of Translating Aging features Robin Mansukhani, CEO and Co-founder of Deciduous Therapeutics, a company that aims to positively impact human healthspan by developing medicines which activate the endogenous immune mechanism responsible for the elimination of senescent cells. Today, Robin shares his insights on how senescent cells develop and how Deciduous Therapeutics eliminates them. Robin begins by explaining what causes the growth of senescent cells. He explains that not all senescent cells are dangerous and discusses the various kinds of these cells. Although senescent cells are prominent in age-related diseases, Robin explains that they are also found in younger people with autoimmune diseases such as juvenile diabetes. He goes on to talk about Deciduous Therapeutics' approach in combating senescent cells by activating the NKT cells. He also shares his thinking about the best directions for human trials. The episode concludes with Robin describing the future of Deciduous Therapeutics, and his focus on impacting people globally in a meaningful way. In this episode, you'll learn how senescence arises, traditional senolytic approaches, and the importance of NKT cells in eliminating these pathogenic celss. Episode Highlights: The origin of senescent cells Why are senescent cells highly pathogenic? Breaking down the different kinds of senescent cells The relationship between senescent cells and age-related diseases Senolytics and senostatics: approaches for getting rid of senescent cells Deciduous Therapeutics' approach What happens when senescent cells overpower NKT cells? The role alpha-galactosyl ceramide on NKT cells The current hurdles Deciduous Therapeutics are trying to overcome How Robin see Deciduous Therapeutics in five years Quotes: “Senescent cells are cells that have been irreversibly damaged, and so they exit the cell cycle.” “It's not about the age of the person. It's more about the biological age of the organ and tissue. So we see senescence, also, in young people.” “If you can take a senescent cell that's pathogenic and make it good again, and make it functional again safely and successfully, that would be very useful.” “The approach here and our mindset going into creating this company was: there's a way that nature intended for this to happen, and it is our job to figure that out.” “Getting the first indication to work means that you'll have a runway to lots of success. But if your first one does not work, in a lot of cases, it might mean the end of the company or the end of the runway because you simply don't get enough funding for multiple clinical trials at once. So it is critical.” Links: Email questions, comments, and feedback to podcast@bioagelabs.com Translating Aging on Twitter:https://twitter.com/BioAgePodcast ( @bioagepodcast) BIOAGE Labs Websitehttps://bioagelabs.com/ ( BIOAGELabs.com) BIOAGE Labs Twitterhttps://twitter.com/bioagelabs?lang=en ( @bioagelabs) BIOAGE Labshttps://www.linkedin.com/company/bioage-labs/ ( LinkedIn) Deciduous Therapeutics Websitehttps://www.deciduoustx.com/ ( DeciduousTx.com)

It's typical for athletic performance to decline with age. (And, athletes may experience signs of accelerated aging caused by intense training.) If you're worried about your declining performance, start looking at how you train and what you eat. We may not be able to reverse our chronological age, but we can guide our bodies through the ageing process.  Did you know that there are longevity strategies specifically for athletes? These strategies consider long-term performance, health, and muscle growth!  In this episode, Dr. Elena Seranova joins us to discuss how ageing can affect our bodies and our athletic performance. She shares her strategies, from supplements to lifestyle changes, that can help athletes combat the effects of ageing. If you're overwhelmed by all of the information out there, remember: you need to build a good foundation first. Start with eating right and sleeping well; from there, you can eventually incorporate Dr. Elena's other recommendations. If you want to learn longevity strategies for athletes and how to improve athletic performance, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how ageing affects athletic performance and why athletes may experience signs of accelerated ageing.  Learn longevity strategies that will support athletic performance and your general health, like how to activate your autophagy pathways. Understand that longevity is a process of building good habits; you can start out by focusing on the basics, like diet and sleep.  Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, which is all about optimising your fitness, lifestyle, nutrition and mental performance for your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, and Run Longer  Without Burnout or Injuries Have you struggled to fit training into your busy life? Maybe you don't know where to start, or you have done a few races but struggle with motivation or injuries? Do you want to beat last year's time, or finish at the front of the pack? Do you want to run your first 5-km, or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. NMN Bio offers pure supplements that are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party-tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing, and is designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility. Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Episode Highlights [02:32] Why Athletic Performance Drops as We Age The main cause of athletic performance decline is mitochondrial decline. Mitochondrial decline is linked to senescence cells.  Senescence cells stop dividing and do nothing. As we age, we may have 5-20% senescence cells in different tissues.  This causes inflammation and causes the mitochondria to function improperly, thus increasing reactive oxygen species within cells.  Nuclear DNA is usually packed in histones, which preserve genetic material. However, mitochondrial DNAs lack histones, making it prone to oxidative stress and mutations.    As we age, our epigenetic processes become less efficient; it becomes a vicious cycle with more reactive oxygen species and less capacity to deal with them.  [08:23] How Else Do Our Bodies Respond to Ageing Ageing declines autophagy, which recycles cellular organelles.  When there's nothing to clean up dysfunctional mitochondria, problems with energy generation arise. Athletes who have exercised intensely their whole life will have worn-off tissues and lactic acid buildup.  Remember, exercise is good, since we want some level of oxidative stress; however, we don't want more oxidative stress than what our body can cope with.  Lisa shares how running ultramarathons accelerated her ageing process, wear and tear, and inflammation.  [12:29] How to Support Autophagy and Athletic Performance?  Intermittent fasting is when people have a certain feeding window a day. After eating, mTOR switches off and AMPK is activated which allows for autophagy.   If you want to build muscle, Dr. Elena recommends eating after exercising so you can activate mTOR which helps with muscle growth.    You need to create a cycle going of mTOR and AMPK since autophagy recycles cells back into amino acids, which can help cells build new proteins.  Don't create a feeding window that's too narrow; you need to have enough fuel for your body. Eat chicken, meat, and foods rich in amino acids.  Make sure you're sleeping properly, as this can affect your muscle growth.  [18:30] Supplements to Support Autophagy and Longevity You can also support autophagy through supplements like berberine.  Dr. Elena recommends adding supplements to specifically target senescence cells. Senolytics help kill senescence cells while senomorphics modify the senescence cells.  Quercetin added with Vitamin C can help kill senescence cells. By itself, quercetin can produce toxic metabolites, so it needs Vitamin C to serve as an antioxidant.  She also recommends taking their quercetin product with NAC and acetylcysteine to boost glutathione, a potent antioxidant.  Quercetin has many benefits including anti-inflammatory properties, and can be used to combat cardiovascular disease, fight seasonal allergies, and can fight cancer.     [26:51] How to Take Quercetin Quercetin can be found naturally in fruits and vegetables like strawberries and onions.  If you've never taken compounds for their senescent action before, start by taking quercetin at 500 mg every day. After a month of taking it, check in on how you feel.  You can also implement detox protocols with a higher dosage of quercetin(around 2 - 2 ½ grams). If you want to implement this protocol, start with 5 days first.  Quercetin can be combined with 500mg of chlorella to boost the detoxifying reaction. People with kidney diseases should consult with a doctor before taking quercetin.   [32:43] How NMN Can Help Athletes  In addition to mitochondrial decline, athletes can experience loss of endurance and muscle loss as they age.  Dr. Elena recommends increasing your fasting window depending on your goals.  You want more oxygenation in your tissues to preserve endurance and muscle.  Dr. Elena offers an NMN product that can increase both endurance and prevent age-related muscle loss.    This can help increase insulin sensitivity, activating longevity genes and DNA repair.  [36:37] How to Optimise NMN  NMN functions optimally when it's attached to a methyl group. Unfortunately, our body's methylation process also declines with age.  NMN should be paired with TMG, as it is a rich methyl donor.  When you combine NMN, TMG, and quercetin, you'll optimise your performance and endurance. [39:11] Longevity is Your Biological Age, Not Your Chronological Age Many people over 40 are insulin resistant. Insulin resistance is a gateway to biological decline.  You can check your insulin resistance by checking your waist to hip ratio.  After the age of 40, it's much easier to experience hormonal dysfunction.  We need to make a conscious effort to improve our health. Ageing can cause issues to spiral if left uncontrolled.   [42:50] Be Careful With Your Food 80% of adults in the west are insulin resistant.  The food industry worsens the condition by offering so many processed carbohydrates.  Many people have false ideas about what a healthy diet is. You can't have too many carbohydrates and sugar, even if they're coming from fruits.  Cut down on carbohydrates, avoid processed foods, and take good oils.  [45:21] Start with the Basics Start with the basics. You don't need to add supplements immediately.  Just eat clean and good food. There's no such thing as a universal diet.  Taking cold showers in the morning can improve hormonal balance. You can start with just 10 seconds of cold exposure.  Manage your stress levels and make sure you move regularly.  You don't need to be perfect.  [50:47] How Some People Live to 100  There were two hypotheses surrounding centenarians: good habits and the absence of high-risk genes. However, some centenarians were found to have bad habits and mutations for Alzheimer's disease.  Centenarians have genes that mitigate risks from bad mutations. They also have low IGF 1 levels.  When people are young, IGF 1 can improve muscle and tissue growth, but it can be harmful when people grow older. Centenarians' genetic combination allowed for IGF to decrease as they grow older. Listen to the episode to learn more about how centenarians' hormonal processes are being regulated. Commit to regularly regulating and balancing your hormones. This process starts with clean food, caloric restriction, and exercise.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Want to learn more from Dr Dom? Check out our previous episode with her:  Episode 238 - Reverse Ageing to Live Longer and Healthier with Dr. Elena Seranova Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova        Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan, M.D.  Centenarians, metformin, and longevity | Nir Barzilai, M.D., Episode 204 from the Peter Attia podcast  Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health Visit NMN Bio to know more about NMN supplements!  

In the April 12, 2022 episode of Better Than Ever Live!, I discuss senolytics – medications and supplements that appear to play a role in the aging process. We also talk about how exercise keeps our muscles from aging, how to overcome coffee consumed late in the day, and the benefits of matcha tea vs. […] The post 54. Senolytics and aging, matcha vs. green tea, and more! appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I've had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements. In today's episode, you will learn: - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more - Richard's thoughts on lifespan vs. healthspan All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld RICHARD MILLER LINKS: Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:55 Richard Miller Intro 1:51 Richard Miller Wildlife photography 3:30 ITP - the gold standard for testing longevity drugs & winning drugs 10:51 Rapamycin, Rapamycin + Acarbose 18:48 Rapamycin + Acarbose Dosing Schedule 20:15 Combination of drugs, Rapamycin + Metformin 21:56 17-Alpha Estradiol 25:45 Canagaflozin 31:34 Does Richard take the 4 winning drugs? 32:46 3 Drugs that have small lifespan effects & promising 36:30 GPLD-1 & shared mechanisms in longevity drugs 44:04 Resveratrol in ITP 46:27 NR, NMN 52:34 Curcumin, Green Tea Extract, MCT Oil 54:54 Fisetin & Senolytics 56:12 Why most published research findings are false 1:00:03 Healthspan biomarkers at the ITP 1:02:38 Can you have healthspan without lifespan? 1:07:37 Fish Oil, Spermidine, Sulforophane 1:12:13 Unpublished data Richard is excited about 1:17:47 Flying Pigs & Aubrey De Grey 1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight.

Explore the latest updates in longevity research in the March 2022 edition of the Rejuvenation Roundup Podcast! More at lifespan.io/roundup

Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today's episode, you will learn: Cellular Senescence and it's dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!) If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld PETER ADAMS LINKS: Lab Website & Bio: http://www.padamslab.org/pages/members.html Peter Adams Twitter: https://twitter.com/AdamsBioAging Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Tohru Minamino is Professor and Chairman of the Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine (https://juntendo-cvbm.com/en/about.html). He also serves as Director of the Cardiovascular Medicine, Juntendo University Hospital. He received his MD from the Chiba University Graduate School of Medicine in 1989 and his PhD from Faculty of Medicine, the University of Tokyo in 1997. Dr. Minamino is a medical cardiologist and research scientist focusing on molecular mechanisms of aging. He started his major research focusing on cardiovascular aging at Harvard Medical School (1997–2000), and his research interests have currently been growing in the biology of aging including metabolic pathways of longevity and senolysis. He has published more than 100 papers including in Nature, Nature Medicine, Cell, Cell Metabolism, and Lancet. Dr. Minamino has won several awards including Satoh Memorial Award in Japanese Circulation Society, and Erwin von Bälz Award (1st prize). 

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They've also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!! Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today's episode. Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/ 2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/ 2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/ 2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG TIMESTAMPS: 00:00 Live Longer World Intro 00:35 Irina & Michael Conboy Intro 1:08 Aging is slowdown in our repair machinery 2:55 Naked Mole Rats not extreme model for longevity 5:37 Heterochronic Parabiosis 16:00 Young Blood to Old Blood Exchange 19:19 Rejuvenation via Neutral Blood Exchange (NBE) 22:56 Old Blood Degenerates Young Mice 25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE 27:16 How long do effects of NBE last? 30:15 How is NBE working mechanistically? 2 waves of rejuvenation 33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative 38:12 NBE vs. Senolytics 40:53 Unanswered Questions on NBE 43:13 Oxytocin & Muscle Functioning; Notch Signaling 48:12 Chickens & Ravens as Pets! Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.

Welcome back to The Optimization Academy with Dr. Greg Jones where I interview some of my favorite innovators in Medicine, Health, Fitness, and Beyond! We are ecstatic to share Part 2 of my talk with Dr. Elizabeth Yurth on Optimizing Strength and Function after 40! Dr. Yurth is the Co-Founder and Medical Director of Boulder Longevity Institute, where she has been providing Tomorrow's Medicine Today to her clients since 2006. Along with her 25-plus years as a practicing orthopedist specializing in sports, spine, and regenerative medicine, Dr. Yurth is double-Board Certified in Physical Medicine & Rehabilitation and Anti-Aging/Regenerative Medicine.. As an athlete herself who has dealt with numerous injuries, Dr. Yurth is thrilled to share with her clients all the innovative, life-changing treatments that are on the cutting-edge of medicine. In Part 2 of our discussion, we are discussing leading edge strategies for healthier aging! Press play and enjoy the discussion on the following topics and more Peptides for healthier aging and maintaining strength Senolytics and Autophagy GLP-1 agonists NAD+ As always thanks for watching and listening *****Connect with Dr. Yurth https://boulderlongevity.com/ and on IG: https://www.instagram.com/dryurth *****Click here to subscribe to my channel: https://www.youtube.com/channel/UCM2Jjqb7MqtZ7VDIuRjguLA/?sub_confirmation=1 *****Connect with me on Instagram: https://www.instagram.com/doctorjones_doctorjones/ *****Connect on Facebook: https://www.facebook.com/GregJonesNMD

In this video Professor Campisi talks about why detecting senescent cells is difficult and the biomarker that her team recently found that shows how effective a senolytic is and can also be used to determine the level of senescent burden. The Campisi lab at the Buck Institute https://www.buckinstitute.org/lab/campisi-lab/ Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.

In this video Professor Campisi talks why we have senescent cells, a possible schedule for taking senolytics, and senescent cells and cancer. The Campisi lab at the Buck Institute https://www.buckinstitute.org/lab/campisi-lab/ Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.

Dr. Judith Campisi, PhD (https://www.buckinstitute.org/lab/campisi-lab/) is a biochemist, cell biologist, and Professor of Biogerontology at the Buck Institute for Research on Aging. Dr. Campisi received a PhD in biochemistry from the State University of New York at Stony Brook and completed her postdoctoral training in cell cycle regulation at the Dana-Farber Cancer Institute and Harvard Medical School. As an assistant and associate professor at the Boston University Medical School, she studied the role of cellular senescence in suppressing cancer and soon became convinced that senescent cells also contributed to aging. She joined the Lawrence Berkeley National Laboratory as a senior scientist in 1991 working with Dr. Mina Bissell. In 2002, she started a second laboratory at the Buck Institute. At both institutions, Dr. Campisi established a broad program to understand the relationship between aging and age-related disease, with an emphasis on the interface between cancer and aging. Dr. Campisi is a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science. Dr. Campisi has received numerous awards for her research, including two MERIT awards from the National Institute on Aging and awards from the AlliedSignal Corporation, Gerontological Society of America, and American Federation for Aging Research. She is a recipient of the Longevity prize from the IPSEN Foundation, the Bennett Cohen award from the University of Michigan, and the Schober award from Halle University, and she is the first recipient of the international Olav Thon Foundation prize in Natural Sciences and Medicine. Dr. Campisi currently serves on advisory committees for the Alliance for Aging Research, Progeria Research Foundation, and NIA's Intervention Testing Program. She is also an editorial board member for more than a dozen peer-reviewed journals. Dr. Campisi is a scientific founder of Unity Biotechnology, a California-based company focused on developing senolytic therapies for age-related pathologies. She has served on the scientific advisory boards of the Geron Corporation, Sierra BioScience, and Sangamo Biosciences.

My guest this week is Dr. Edwin Lee Co-Founder of Clinical Peptide Society. In this episode, Dr. Edwin Lee and I discuss peptides, his book, and the many ways to heal the body without surgery. We also discuss stem cells, growth hormone secretagogues, and his passion project saving peptides from being taken away by the FDA. You can learn more about that here. Thank you to our sponsor Oxford HealthSpan. Primeadine is the best formulated Spermidine supplement on the market!  What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine!  I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”.  Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin, and nails!   Sponsor offer: If you haven't tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15% at https://oxfordhealthspan.com/products/best-spermidine-supplement Dr. Lee Bio:Dr. Edwin Lee is an endocrinologist, author, and international speaker. Dr. Lee founded the Institute for Hormonal Balance, Orlando, FL in 2008, is board-certified in Internal Medicine, Endocrinology, Diabetes, and Metabolism, and has completed special training in Regenerative and Functional Medicine.  He is a graduate of the Medical College of Pennsylvania and finished his fellowships of Critical Care Medicine and Endocrinology, Diabetes and Metabolism at the University of Pittsburgh. Follow Dr. Edwin Lee Save Peptides Website Peptide Study   Episode Timestamps: [05:20] How Dr.Lee got to where he is now… [10:49] Turning a patient's life around with peptides, exosomes and stem cells… [13:55] The difference between stem cells and exosomes… [20:35] Kisspeptin-10, does it actually help with testosterone? [23:50] Studies on knee pain treated with BPC-157… [41:30] Bioregulator peptides for prostate issues… [43:52] Growth hormone secretagogues: do they work, how do you monitor them, ect… [47:00] Are you a mouth breather?.. [50:41] Study on regeneration of the thymus gland using DHEA, metformin and growth hormone… [54:14] Do you see people whose bodies do not like secretagogues?.. [56:30] Thoughts on senolytics? What are the best senolytics… [67:45] How to save peptides and why does the FDA want to take them away?..   Follow Nat: Facebook Facebook Group  Instagram Work with Nat: Book Your 20 MInute Optimization Consult    

2021 年 9 月 4 日，《麻省理工科技评论》发布报道，称亚马逊创始人 Jeff Bezos 和硅谷著名投资人 Yuri Milner 在近期投资了专注于抗衰方向的生物科技公司 Altos Labs，一家今年四月才成立的抗衰老公司，科学家团队包括 2012 年诺贝尔生理学或医学奖的获得者山中伸弥；截至今年六月，该公司已经吸引了至少 2.7 亿美元的投资。这并非硅谷富豪们第一次入局抗衰领域。 2018 年， Jeff Bezos 和 PayPal 联合创始人 Peter Thiel 共同投资抗衰领域独角兽 Unity Biotechnology；而更早之前，还有谷歌创始人 Larry Page 宣布 10 亿美元投资生物科技公司 Calico，目前 Calico 已经被整合至谷歌母公司 Alphabet Inc。我们似乎可以清晰地看见，在颠覆互联网、物流制造、航空航天等领域之后，硅谷大佬们的下一个目标，正是通过生物工程技术突破人类目前的寿命上限，将长生不老的选择权紧紧握在手里。 本期节目，我们邀请到了同样在抗衰领域被视为明星公司的硅谷新贵 Gordian 的首席科学家 Martin Borch Jensen。他和主播 Diane 一起探讨了硅谷的投资者们都是出于什么原因投资 Altos Labs 等生物科技公司，值得关注技术路径有哪些，投资人应该如何看待生物科技领域的超长投资周期和技术挑战，头部公司可以通过什么途径实现商业回报。 #加入我们# 声动活泼正在招聘「内容研究员」、「业务拓展和合作管理总监/经理」、「声音设计师」、「播客制作实习生」、「内容营销负责人」及「节目制作人」，查看详细讯息请在公号「声动活泼」回复暗号：入场券 。简历接收邮箱

Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most well known for his popular blog Fight Aging! where he distills the latest research in aging science. For anyone looking to stay informed on aging & longevity research, I highly recommend you checking it out - it's one of the best resources out there. In today's conversation, we discuss how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more. Note: We discuss a fair bit on cellular senescence and senolytic therapies. For those unfamiliar with the concept, cellular senescence is a process in which cells lose their ability to divide but refuse to die. When these senescent cells don't get cleared away, they release harmful substances and damage the cells around them too. It is well known that senescent cells accumulate with age, contributing to inflammation and aging itself. Senolytics is a class of drugs that can selectively clear away these senescent cells and they have shown promise in delaying and preventing age-related diseases. FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW REASON AND REPAIR BIOTECHNOLOGIES: Fight Aging! Blog: https://www.fightaging.org/ Company Website: https://www.repairbiotechnologies.com/

 Senolytics are certain drugs that clear out aging cells that have stopped dividing (senescent cells). Dr. Charles Mok of Allure Medical discusses how understanding the nature of these cells will help further the research that is developing around the topic of aging and lifespan.

Maximize the effects of fasting with science. Learn from Dr. John Lieurance how using NAD+, Senolytics and cell activators allow for a three-day fast to be as effective as a five-day fast!To get a free download of Dr. Lieurance's book, go to www.melatoninbook.com and use code gowellness!

Colleagues, if you’ve been following me for any time, you’ve heard me speak frequently about aging as the top driver of chronic disease. In today’s interview, I dive into evidence-based integrative protocols to slow down and reverse the aging process. My guest, Dr. Joseph Cleaver MD, is a Fellow of the American Board of Anti-aging and Regenerative Medicine, is board-certified in internal medicine, a rheumatologist, on faculty at A4M and MMI and has authored and published a wealth of research and scholarly articles. He founded Paradigm Wellness Medical Group in Dallas and Sonoma Valley, California, AND he is Medical Director at Boutique Wellness in Winston, North Carolina. Folks, you’ll want to be ready to take notes during this interview, as Dr. Cleaver shares his personalized senolytic protocols specific to patient phenotypes. Listen, share, and leave a starred rating, if you wouldn't mind! Thanks for listening. ~DrKF

Maximize the effects of fasting with science. Learn from Dr. John Lieurance how using NAD+, Senolytics and cell activators allow for a three-day fast to be as effective as a five-day fast!

Steve Matheson invents things to help people stay youthful. I've been taking his Senolytic stack to help rid my body of zombie cells that are slowly accumulating in my body.  Email him at steve@combilytics.com In this fascinating episode of we cover: •Senoliytics stack - what does it do? •All 240 types of cells emit chemicals - all of them can become senescent •Desatenib, Quercetin, Polyphenols, TCM - effective ingredients. •Senescent cells are important to our body. But they don’t die. The turn into zombie cells that accumulate, emit chemicals and recruit others •Newborn have 5-7% By full maturity - up to 18% at end of life •Our immune system when strong have the capacity to rid the body of senescent cells •The process of researching combinations of compounds for longevity, cancer Alzheimers and more. •Doing 1 course a year, 35-40, 2 courses 40-50, 3 courses 50-60 •Steve’s experience of regrowing hair, and resolving skin issues through his Senolyitics stack •What’s the future of customized health and medicine. •The importance of biometrics •Increased HRV, decreased CRP, *Steve’s 8 daily biohacks: Senolytics, Red light therapy, katsu, vagus nerve stim, fasting, breathing, meditation, kittens

Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Alexandre Kalache, President of the International Longevity Centre-Brazil (ILC-Brazil). Ira Pastor Comments: As we continue our virtual road-trip around the globe per the World Health Organization's (WHO) Age Friendly Cities Global Movement, during the WHO defined “Decade of Healthy Aging”, we are headed down to the southern hemisphere to the country of Brazil. Dr. Alexandre Kalache: Dr. Alexandre Kalache is a medical epidemiologist specializing in the study of aging, who is the President of the International Longevity Centre-Brazil (ILC-Brazil), an independent think tank based in Rio de Janeiro that develops and promotes policy related to population aging, and Co-President of the Global Alliance of International Longevity Centres, an international consortium of member organizations with a mission to help societies to address longevity and population aging in positive and productive ways. Dr. Kalache graduated from the medical school of the Federal University of Rio de Janeiro, gained diplomas in infectious and parasitic diseases and medical education, was awarded a master's degree in Social Medicine from the London School of Hygiene and Tropical Medicine, his PhD in Epidemi ology at the University of London, and had a long academic career at the Universities of London and Oxford in the United Kingdom. Dr. Kalache's work in Aging: Dr. Kalache formerly directed the WHO Global Aging Program, known as the Department of Aging and Life Course, at its Geneva headquarters, which resulted in the development of the assessment tool for use by city planners and advocacy groups, known as the Global Age-Friendly Cities Guide. Dr. Kalache was formerly Senior Policy Advisor to the President on Global Aging, New York Academy of Medicine (NYAM), a representative to the United Nations for the International Association of Gerontology and Geriatrics, Global Ambassador to HelpAge International, Research Chair Professor in Elderly Health Care Development at King Saud University in Riyadh, Saudi Arabia, Associate Professor at the Andalusian School of Public Health in Granada, Spain, and member of the Brazilian Delegation to the United Nations' Open-Ended Working Group on the Human Rights of Older People. On this ideaXme episode we will hear from Dr. Kalache about: His background; how he developed an interest in medicine, in public health, and in aging research. About ILC Brazil and its mission and focus. About his WHO Global Age-Friendly Cities initiatives in Brazil in the cities of Balneário Camboriú, Jaguariúna, Pato Branco, Esteio, Veranópolis, and Porto Alegre. His views on the Covid-19 situation in Brazil, and other developing countries, exploring issues such as unpreparedness, inequalities, lack of resources, ageism, poor scientific understanding from governments, gender and race issues. Interesting biotechnology research occurring in Brazil. Credits: Ira Pastor interview video, text, and audio. Follow Ira Pastor on Twitter: @IraSamuelPastor If you liked this interview, be sure to check out our interview on Senolytics! Follow ideaXme on Twitter: @ideaxm On Instagram: @ideaxme Find ideaXme across the internet including on iTunes, SoundCloud, Radio Public,TuneIn Radio, I Heart Radio, Google Podcasts, Spotify and more. ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd. Visit ideaXme's website www.radioideaxme.com

Andy Koff is the Founder of Atropos Therapeutics. A company with a new approach to tackling senescent cells, one fo the biggest hallmarks of aging.Atropos Therapeutics uses a bio marker to identify when a cell starts transitioning from a quiescent cell into a senescent cell. Using this bio marker, Atropos aims to be able to prevent the cell from transitioning into a senescent cell, they've dubbed this type of technology a "senosuppressant"For 25 years or so, starting with his post-graduate work at the Fred Hutchinson Cancer Center with Jim Roberts, and into his faculty position at Memorial Sloan Kettering Cancer Center, Andy has used a multitude of approaches, biochemical, genetic and cellular, to identify the proteins and the mechanisms that control how cells choose between duplicating themselves, known as proliferating, or remaining in a non-proliferating state. This decision is incorrectly made in virtually all cancer cells, thus providing the framework to explain much about how drugs work in oncology.About five years ago, Andy’s attention shifted to another decision…how cells maintain themselves in the non-proliferating state and what might be the consequences to not being able to do so. His work today has applications in both oncology and in aging and age-related diseases.-James Ruhle, SimpleBioTechPodcast.com Stay up to date with the latest episodes and BioTech updates by following me on instagram @SimpleBioTech If you want to know which BioTech companies I'm currently excited about, connect with me on Angel List at Angel.co/jamesruhle

SHR # 2497 :: Dr. Michael Lisanti, MD - PhD - The oldest in our global population have suffered the greatest mortality from this pandemic outbreak. Experts warn that this of us over 60 years of age are at greatest risk of dying. Many of us in this audience already use senolytic agents to help push back biological aging. Are these strategies helpful in protecting against COVID-19 as well? Is there a difference in the death toll of those who are chronological 0ver 60 years old versus a 65 year old person who is biologically 40? And what of time restricted feeding? It imparts some of the same benefits as senolytics. We learn the answers to these and more on today's show. - Dr. David Nieman DRPH - Today’s interview discusses research discoveries within 4 areas of exercise immunology that have received the most attention from investigators: 1- acute and chronic effects of exercise on the immune system, 2- clinical benefits of the exercise–immune relationship, 3- nutritional influences on the immune response to exercise, and 4- the effect of exercise on immunosenescence.

SHR # 2497 :: Dr. Michael Lisanti, MD - PhD - The oldest in our global population have suffered the greatest mortality from this pandemic outbreak. Experts warn that this of us over 60 years of age are at greatest risk of dying. Many of us in this audience already use senolytic agents to help push back biological aging. Are these strategies helpful in protecting against COVID-19 as well? Is there a difference in the death toll of those who are chronological 0ver 60 years old versus a 65 year old person who is biologically 40? And what of time restricted feeding? It imparts some of the same benefits as senolytics. We learn the answers to these and more on today's show. - Dr. David Nieman DRPH - Today's interview discusses research discoveries within 4 areas of exercise immunology that have received the most attention from investigators: 1- acute and chronic effects of exercise on the immune system, 2- clinical benefits of the exercise–immune relationship, 3- nutritional influences on the immune response to exercise, and 4- the effect of exercise on immunosenescence.

Professor Michael Lisanti, Chair of Translational Medicine at the University of Salford joins David Gornoski and physicist Weiping Yu to discuss his work using antibiotics to destroy senescent cells-dysfunctional aging cells-as well as cancer stem cells. These generic, very inexpensive antibiotics have studies showing antiviral effects in other viruses. Dr. Lisanti proposes that clinical trials should be conducted using these antibiotics for COVID-19 coronavirus. Senescent cells in the lungs act as host receptors for COVID-19. If anti-aging drugs and senolytics can be used to destroy senescent cells, this may be a promising area of research for virologists.

Today's episode is an interview with Tim Cash, Chief Science Officer of Senolytx Therapeutics, one of the six daughter companies of David Sinclair's Life BioSciences. In this episode Tim helps me to understand exactly why senescent cells, and the damage they cause to the human body is such an important issue we, as humans, need to fix. If you're interested in learning why and how the human body ages, you're going to love this episode.We go over the different methods and theories behind fixing senescent cells:senolytics, senomorphics, and utilizing the immune system to get rid of them naturally, as well as touch on how Senolytx is navigating the regulatory hurdles by focusing on Fibrosis initially, as their main target, with the broader goal of targeting aging as a whole as they progress through clinical trials. We also go into some of the promising results Senolytx is seeing with their therapies, and Tim enlightens me on some of the most exciting things happening in BioTech right now, and where he see's things in the next 5, 10, and 15 years. -James Ruhle, SimpleBioTechPodcast.comStay up to date with the latest episodes and BioTech updates by following me on instagram @SimpleBioTech If you want to know which BioTech companies I'm currently excited about, connect with me on Angel List at Angel.co/jamesruhle

Explore the latest updates in longevity research in the November 2019 edition of the Rejuvenation Roundup Podcast, hosted by Ryan O'Shea of Future Grind! More at lifespan.io/roundup

Luke O'Neill, Professor of Biochemistry at Trinity College Dublin discusses Senolytics: might a new pill being developed by scientists spell the end for ageing?

It took me a month to upload this one, but it is still relevant today: I have removed myself from 80%er culture- I had never heard of Nipsey Hussle before. Can you say the same? A lot of people would be better off if they got into "Bitcoin culture". Zehut news from Israel. Cashless thoughts. Onions, Andrew Yang, Senolytics, Baltimore, scapegoating, social war, and more! WATCH the show here- https://www.youtube.com/watch?v=jKQLbMa5dSA Follow Adam on Twitter- https://twitter.com/TechBalt All of the BitcoinMeister videos are here at DisruptMeister.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/bitcoinmeister/support

Explore the latest updates in longevity research and anti-aging science in the April 2019 edition of the Rejuvenation Roundup Podcast, hosted by Ryan O'Shea of Future Grind! More at lifespan.io/roundup

In this episode, I speak to an original anti-aging doctor who has been part of the anti-aging movement since 1994! He has had a practice for over two decades, and has seen all the advancements in anti-aging medicine. I ask him for his anti-aging tips and we discuss the future of anti-aging medicine. This is a great interview with Dr. Philip Miller. We first discuss how he sees patients and works with them in details to achieve their goals. He checks and reviews hormones such as Estrogen, Progesterone, Testosterone, Thyroid, Adrenals and may more.  We discuss the near future of anti-aging medicine and what developments he sees on the near horizon. Dr. Miller touches on Senolytics for Senescent cells, Telomere extension drugs, winning thw war over cancer, and tumor suppressors. We also discuss his unique anti-aging hacks that we can use to look and feel younger while we live longer and healthier. His website is: www.antiaging.com, blog is at blog.antiaging.com, flicker account is: https://www.flickr.com/photos/philipleemiller/ You can see the entire shownotes at https://antiaginghacks.net. Visit us on instagram at @antiaginghacks and on facebook at facebook.com/antiaginghacks.

Dr. Bill Andrews is the Founder and CEO of Sierra Sciences, a company focused on finding ways to extend human lifespan and health span through telomere maintenance. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. As a scientist, athlete and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been aging. In the early-to-mid 1990’s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences. Sierra Sciences does not do research on animals, choosing to focus primarily on humans. Nonetheless, other labs using Sierra Sciences technologies have shown that lengthening telomeres, using the enzyme telomerase, can provide significant health benefits including reversal of aging and declining health in every way imaginable. An interview by Diane Sawyer describes the results from an animal study done at Harvard. See https://www.youtube.com/watch?v=Np7cR7Z6UGA. Bill is presently conducting a clinical study on humans using the same technologies applied successfully to animals. The first patient is scheduled to be treated in early May of 2019. See www.libellagt.com Bill was awarded 2nd place as "National Inventor of the Year" in 1997 for his cancer research. Bill earned his Ph.D. in Molecular and Population Genetics at the University of Georgia in 1981. He then served as Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Berlex Biosciences and at Geron Corporation, and Director of Technology Development at EOS Biosciences, before starting Sierra Sciences in 1999 where he now serves as President & CEO as well as Chief Scientific Officer. Bill is also a named inventor on over 50+ US-issued patents on telomerase and author of numerous scientific research studies published in peer reviewed scientific journals. Bill is also an avid ultra-marathon runner. He regularly competes in 50 and 100+ mile races often finishing at the top of his age group. These grueling races have taken him all over the world to race in some of the most extreme environments, from Death Valley to the Himalayas. His running is presently featured in the movie The High. See www.thehighdoc.com. He considers endurance exercise, when done properly, to be a way to significantly slow down the aging process. Bill’s obsession is to cure aging, and that includes his own aging. His regimen to slow down his own aging and declining health is unique and based on years of his own research. Videos of Bill Speaking at conferences: https://www.youtube.com/watch?v=_2A2i3Jn63Y https://www.youtube.com/watch?v=OcnuSaLNF5c https://www.youtube.com/watch?v=Mqb1D8Bwkc4 Books that Bill has written: https://docs.wixstatic.com/ugd/3670e5_6c31b0ef285f4449baea4e8bd43c0329.pdf https://www.amazon.com/Bill-Andrews-Telomere-Basics-Curing/dp/0615949983/ref=sr_1_1?ie=UTF8&qid=1504042407&sr=8-1&keywords=BILL+ANDREWS https://www.amazon.com/Telomere-Lengthening-Curing-Disease-Including/dp/0692830111/ref=sr_1_1?s=books&ie=UTF8&qid=1504731075&sr=1-1&keywords=telomere+lengthening Partners that sell products discovered at Sierra Sciences: Isagenix (https://www.isagenix.com/en-us/products/vitality-well-being/individual/isagenesis?sc_camp=1871196FA683432B9A2D81790F9CDA99&gclid=EAIaIQobChMI4evX7vDp4AIVax-tBh0dZQs8EAAYASAAEgI6NfD_BwE) Defytime (www.defytime.com) Libella Gene Therapeutics (www.libellagt.com). ALCAT, mentioned in this podcast:  https://cellsciencesystems.com The Kaufmann Protocol: Why We Age and How to Stop It https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop-ebook/dp/B07BDKWVZH Prevent and Reverse Heart Disease by Caldwell B. Esselstyn Jr. M.D. https://www.amazon.com/dp/B000SEK74M/ref=dp-kindle-redirect?_encoding=UTF8&btkr=1