Podcasts about senolytics

You don't die of old age. You die of the diseases aging causes — and Dr. Sandra Kaufmann says we can fight back.In this episode of Transparent with Tina, longevity physician Dr. Sandra Kaufmann breaks down the science of aging in a way that actually makes sense. From the 7 Tenets of Aging to cutting-edge tools like exosomes, NAD+, NMN, and senolytics — this conversation will change how you think about your body, your health, and your future.We go deep on:

Marco Quarta is co-founder and Chief Scientific Officer of Rubedo Life Sciences, a precision-therapeutics company developing medicines that target the pathological cell states that drive age-associated disease. Marco's first appearance on the show was three years ago, in February 2023 (Episode 35), when Rubedo was a much earlier-stage company committed to the then-contrarian premise that "the senescent cell" is not a single entity but a heterogeneous family of cell states that needs to be deconvoluted at the single-cell level. In March 2026, Rubedo reported preliminary Phase 1b/2a clinical data for its lead candidate, RLS-1496, a first-in-class topical GPX4 modulator. Marco returns to the show to discuss what survived contact with human biology.In this episode, Chris and Marco unpack the readout from Rubedo's basket trial across four skin indications — psoriasis, atopic dermatitis, actinic keratosis, and photoaged skin — and the biology that underlies it. RLS-1496 came clean on safety in all four indications, with significant efficacy signals despite small patient numbers and short (20–30 day) treatment courses. More provocatively, the clinical and translational data have pushed Marco to redefine what kind of drug this actually is. Rather than a next-generation senolytic, GPX4 modulation appears to act as a state-gating intervention: it triggers ferroptosis in deeply senescent cells that have already crossed a redox threshold, while inducing a hormetic "redox reset" in stressed-but-recoverable cells that restores them to a healthier state. Marco proposes a new category to capture this dual action — adaptive senotherapeutics, or senoadaptive drugs — distinct from senolytics and senomorphics.The conversation traces the arc from Rubedo's founding thesis to a clinically validated platform (ALEMBIC, the AI-enabled single-cell multiomics engine that surfaced GPX4 as a target), through the strategic logic of leading with skin, into the broader question every longevity-biotech founder eventually has to answer: when does a disease-by-disease franchise become a credible preventive geroscience platform? Marco lays out the GLP-1 analogy explicitly — an anchor indication and a label-expansion roadmap that could carry GPX4 modulation from dermatology into respiratory, neurodegenerative, and metabolic disease, and ultimately into the use case where biomarkers of cellular senescence flag patients for therapy decades before disease becomes clinically apparent.The Finer Details:How Marco's 2023 contrarian view — that "senescent cells" hide a tissue- and state-specific reality — has been reinforced by the clinic, and how Rubedo's framing has shifted from "targeting senescent cells" to "targeting pathological cell states"The biology of GPX4 as a lipid-peroxidation gatekeeper, why senescent cells have intrinsic vulnerabilities (p16, p21, CDK4/6 inhibition) that make them ferroptosis-sensitive, and how Rubedo's approach differs from oncology-focused GPX4 programs at Takeda and othersThe "senoadaptive" mechanism — RLS-1496 eliminates GPX4-dependent senescent cells via ferroptosis while triggering NRF2/Keap1-driven redox reset, autophagy, and epigenetic remodeling in recoverable cells, restoring tissue trajectory from degenerative to regenerativeWhy Rubedo led with skin: clean regulatory path, accessible tissue, the ability to read out aging biology anddisease in the same trial, and a label-expansion runway into systemic indicationsPhase 1b (Europe) and Phase 2a (US) basket-trial results across psoriasis, atopic dermatitis, photoaged skin, and actinic keratosis: clean safety in 4/4 indications and significant efficacy signals — itch reduction in atopic dermatitis, decreased lesional thickness in psoriasis, target-engagement-correlated clinical improvement in photoaged skinThe richness of the translational dataset: biopsies, tape-stripping, spatial transcriptomics, proteomics, multiplex histomics, plasma biomarkers — all feeding back into ALEMBIC to refine the platformWhy actinic keratosis is the most strategically important indication — an age-related, chronic-inflammatory, precancerous condition where Rubedo can simultaneously test disease modification and biological-age reversalThe Rubedo–Beiersdorf partnership and the cosmetic vertical as a parallel commercial axisPipeline beyond skin: targeting aberrant basaloid stem cells in IPF and other pulmonary indications using different modalities (prodrugs, PROTACs, ADCs) to achieve cell-state selectivityThe longer-arc vision: senescence biomarkers as a "prediabetes-style" early signal, with senoadaptive drugs deployed decades before disease — and what a GLP-1-scale franchise might look like for GPX4 modulationQuotes:"There is not such a thing as a senescent cell — like there is not a cancer cell. And that was the initial idea. I'm glad that over time the field evolved. Now this is an accepted concept in the senotherapeutic space.""We are really talking about a dual function of RLS-1496 that can modulate the cell state depending on the adaptive response. That's why we call this — de facto — a new class of senotherapeutics. We call them adaptive senotherapeutics, or senoadaptive drugs — not a senolytic or a senomorphic, but working by modulating the cell state.""The best animal model for human therapies is human. As much as you can do preclinical work in animal models, it's always an approximation. We were able to test this directly in patients for safety, and in 4 out of 4 indications, we didn't have any safety signal.""Imagine you're taking care of a growing tree, and this tree has some dead leaves and some are a little bit stressed. If you shake the tree, the dead leaves will fall; the healthy leaves will not, because they're healthy and they resist the shake. But that shake actually gives the stressed leaves space and breathing room, and helps them to regain vitality. That's a little bit what GPX4 modulation does.""Senotherapeutics is a large, growing field — an untapped therapeutic opportunity. There is no such thing as a pan-senolytic or a pan-senotherapeutic, like there is no pan-oncotherapeutic. You need to understand the context. But these will all be part of the arsenal for true longevity medicine.""I don't see this as prevention of disease. The way I see therapies like ours, and the way the field of longevity is developing, is treating diseases decades before they develop. That's not a new concept — that's what we're doing in diabetes. You can be diagnosed with prediabetes today and reverse those biomarkers with lifestyle changes or metformin, and maybe never develop diabetes. That's exactly what we're doing here.""First of all, celebrating the first approved drugs from Rubedo — I don't think we're too far from that. But that's also a beginning, because you learn from the big momentum the GLP-1 agonists created: how a drug can start in one indication, create a new field, and prove that you can go beyond that. I hope in a few years we come back and talk about the next GLP-1 — this could be GPX4 modulators, or the senoadaptive drugs that are first in our pipeline."Links:Rubedo Life Sciences: https://www.rubedolife.comMarco Quarta's previous appearance on Translating Aging: Ep 35 — Targeting Pathologic Cells to Preserve Biological Youth

Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells.Dr. Amit Sharma leads the senescence immunology group at the Lifespan Research Institute, where his lab studies how natural killer cells and gamma delta T cells interact with senescent cells — and how that relationship breaks down with age. In this conversation, we explore the biology of immune surveillance of senescence, why it fails as we get older, and what his lab is doing to restore and enhance it. We also discuss the iron-ferroptosis connection, next-generation senolytics, and what the next decade might bring for senotherapy.

On this episode of Vitality Radio, Jared dives into three cutting-edge supplements gaining attention in the world of longevity and metabolic health: fisetin, spermidine, and butyrate. These compounds work in complementary ways—supporting the body's natural ability to clear aging cells, promote cellular renewal, and optimize gut-driven metabolic signaling. Jared breaks down how “zombie cells” (senescent cells) contribute to inflammation and aging, how autophagy supports cellular efficiency, and why gut health plays a central role in cravings, blood sugar balance, and GLP-1 activity. He also shares practical insights on dosing strategies, including pulse dosing, and how to determine if these advanced tools may fit into your current wellness routine. If you're looking to better understand the connection between cellular health, metabolism, and gut function, this episode offers a thoughtful, research-informed perspective.Products:Buy Fisetin AND Spermadine, get 20% off the sale price! (limited time)Buy 3 or more bottles of GLP-1 Metabolic Optimizer, get $10 off each bottle! (limited time)RegenerLife Sodium Butyrate Postbiotic PacketsJust Ingredients Probiotic Complex - capsulesViRadChem BinderMagnesium BisglycinateAdditional Information:#627: GLP-1 Explained Part 1: How to Support Metabolism Without Drugs#628: GLP-1 Explained Part 2: The Lifestyle Blueprint for Real Metabolic OptimizationVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Learn how fasting, senolytics, and supplements like NMN and honokiol help cleanse cells, kill zombie cells, and reverse aging. #Fasting #Senolytics #Supplements #HealthTalks

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Uri Alon, Professor at Weizmann Institute of Science. They explore a systems view of aging that treats longevity as a solvable model, not a grab bag of disconnected theories.Uri explains aging with a simple story: houses make garbage, trucks remove it, and the village has a threshold for how much damage it can handle. In the body, “garbage” can include damaged and senescent cells, “trucks” can include immune cleanup, and “houses” can include long-lived cells and stem cells that drift over time. The model links this balance to death, disease, and steady decline, and it helps predict which interventions actually change it.They also revisit the role of genes. Uri argues that lifespan looks closer to 50% heritable today after correcting for early, non-aging deaths in older datasets. The rest comes from the environment and biological noise, which regular sleep may help reduce.Guest-at-a-Glance

Adeline Atlas 11 X Published AUTHOR Digital Twin: Create Your AI Clone: ⁠⁠⁠https://www.soulreno.com/digital-twin⁠⁠⁠SOS: School of Soul Vault: Full Access ALL SERIES⁠⁠⁠⁠https://www.soulreno.com/joinus-202f0461-ba1e-4ff8-8111-9dee8c726340⁠⁠⁠Instagram: ⁠⁠⁠⁠https://www.instagram.com/soulrenovation/⁠⁠⁠Soul Renovation - BooksSoul Game - ⁠⁠⁠https://tinyurl.com/vay2xdcp⁠⁠⁠Why Play: ⁠⁠⁠⁠https://tinyurl.com/2eh584jf⁠⁠⁠How To Play: ⁠⁠⁠⁠https://tinyurl.com/2ad4msf3⁠⁠⁠Digital Soul: ⁠⁠⁠https://tinyurl.com/3hk29s9x⁠⁠⁠Every Word: ⁠⁠⁠⁠⁠http://tiny.cc/ihrs001⁠⁠⁠Drain Me: ⁠⁠⁠⁠https://tinyurl.com/bde5fnf4⁠⁠⁠The Rabbit Hole: ⁠⁠⁠https://tinyurl.com/3swnmxfj⁠⁠⁠Destiny Swapping: ⁠⁠⁠https://tinyurl.com/35dzpvss⁠⁠⁠Spanish Editions: Every Word: ⁠⁠⁠https://tinyurl.com/ytec7cvc⁠⁠⁠Drain Me: ⁠⁠⁠https://tinyurl.com/3jv4fc5n⁠⁠⁠

Dr. Jerry Mixon on Longevity Medicine: Hormones, Body Fat, Muscle, and Senescent Cells Dr. Jerry Mixon describes “longevity medicine” as treating aging—the progressive loss of capacity—as a medical problem focused on healthspan, not vanity. He shares that at 78 he has maintained a global hormone balance targeted to a healthy 25-year-old range for 31 years, enabling significant strength and endurance gains compared with age 50, and argues more older men should live energetic lives. Mixon emphasizes reducing excess body fat as a priority because fat acts as an inflammatory gland linked to chronic disease, while muscle acts as a healing gland producing beneficial proteins; he advocates building muscle and managing blood sugar/insulin resistance. He explains mitochondrial fragility, senescent “zombie” cells, and immune-system decline, discusses using senolytics such as dasatinib plus quercetin, and describes developing testing to measure senescent T-cell load. The conversation also covers clinic protocols, lifestyle micro-bursts of exercise, family priorities, and aligning healthcare incentives toward prevention. 00:00 Rewriting Old Age 01:46 Longevity Medicine Defined 03:24 Aging as Disease 05:05 How We Peak and Decline 06:15 What Aging Really Is 08:24 From 50 to 78 11:38 Mindset and Metrics 14:52 Start With Getting Lean 17:13 Fat vs Muscle Signals 18:56 Hormones Back to 25 20:26 Testosterone Myths 24:07 Risks and Screening 25:54 Inside the Clinic Process 29:00 Fat Inflammation Cascade 33:20 Insulin Resistance Explained 36:32 GLP-1s and Muscle 37:45 Mitochondria 101 41:14 Senescent Cell Zombies 42:41 Autophagy and Immune Cleanup 44:31 Immune System Senescence 46:10 Hormones and Senescent Load 48:54 Clearing Senescent Cells 50:33 Lifestyle Levers Exercise 53:21 Senolytics and Measuring SASP 56:54 Testing Immune Senescence 58:29 COVID and Aging Immunity 01:01:17 Personal Results and Routine 01:08:26 Family Legacy and Purpose 01:12:54 Reforming Healthcare Incentives 01:19:42 Wrap Up and Disclaimer

Modern longevity culture can make "the perfect protocol" feel like the answer—especially when you're a busy mom who wants more energy now and a longer healthspan. Dan Pardi from Qualia (code: BRITTANY) breaks down what's changed in longevity science over the last 25 years—and why "healthspan" (feeling strong, clear, and capable for longer) matters more than simply living longer.  We get into the real trade-offs of fasting, protein, and vitality, plus a clear explanation of what stem cells actually do, why they decline with age, and how "stem cell wellness" differs from clinic-based stem cell therapy. Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. WE TALK ABOUT:  00:00 - Why longevity finally feels "hackable" 03:55 - NAD explained and why it became an early longevity focus 10:10 - The fasting trade-offs that can crush vitality and metabolism 14:25 - Healthspan vs lifespan and what "living well longer" really means 24:45 - The non-negotiable foundations that beat any "longevity stack" 26:55 - What "stem cell wellness" is (and what it's not) 36:25 - Exosomes explained and why they're everywhere right now 44:25 - The truth about "plant stem cells" in skincare 51:30 - Senescent "zombie" cells, inflammation, and the case for senolytics RESOURCES: Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. Explore my luxury retreats designed to restore your nervous system, optimize health, and support true longevity. Download the non-toxic baby registry guide to reduce toxic exposure and make confident, evidence-informed choices for your family—free. Qualia's website (code: BRITTANY) and Instagram LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music  

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/As we close out 2025, I'm sharing a comprehensive and honest review of my personal health optimization protocol. I break down the exact lifestyle habits, supplements, and medications I use daily, and just as importantly, which popular ones I avoid and why.I detail the massive impact of my "Four Pillars" and explain the thought process behind each item in my regimen, from Omega-3s and creatine to testosterone, SGLT2 inhibitors, and rapamycin.If you've ever wondered what a data-driven, no-BS approach to longevity looks like in practice, this is it.*Timestamps:*00:00 - Podcast Start / Topic Overview01:16 - Philosophy: Focus on Foundations, Not Hype02:10 - The Four Pillars of Healthspan (Eat, Move, Sleep, Connect)03:27 - My Personal Pillars Assessment04:33 - Avoiding Risky Behaviors (Alcohol, Drugs, Environment)06:44 - Pillar 1: EAT - My Rules, Keto Bread, Protein Sources09:51 - Pillar 2: MOVE - Weekly Exercise Routine (Zone 2, Weights, HIIT)12:19 - Pillar 3: SLEEP - Routine & The Alcohol Effect13:29 - Pillar 4: CONNECT - Relationships & Personal Growth14:52 - SUPPLEMENTS: My Skeptical Philosophy16:43 - Supplement Disclosures (Past/Present Company Ties)17:47 - My Daily Supplements List: Omega-3, Vitamin D, Rejuvent (CA-AKG), Lithium, Methylfolate, Creatine23:03 - Supplements I DON'T Take: Magnesium, Collagen, Fiber, Ashwagandha, NAD+ Boosters, Senolytics & Why28:42 - How to Choose a Supplement Brand (ConsumerLab Warning)30:19 - MEDICATIONS & PREVENTATIVE DRUGS30:48 - Testosterone Therapy: My Protocol, Impact, & Monitoring33:49 - Jardiance (Empagliflozin): SGLT2 Inhibitor for Biomarkers35:55 - Repatha (PCSK9 Inhibitor): For Heart Disease Prevention37:47 - Tirzepatide (Mounjaro/Zepbound): My Microdosing Experience40:01 - Rapamycin (Sirolimus): My Cyclical Protocol & Stance on Recent News41:41 - Tadalafil (Cialis) & Metformin: Why I'm Off/Against Them For Now46:08 - Final Summary & Take-Home Principles46:50 - The Importance of a Good Doctor & Rational Risk/Reward48:48 - Wrap-Up & Holiday WishesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispan

Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.

One on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USThe Lila Code: https://orcid.org/0009-0008-4612-3942

Grab the Supplements We Discussed In This Episode: www.qualialife.com/growthnow and use the code 'GROWTHNOW' for an additional 15% OFF your order In this episode, I'm joined by Dr. Dan Pardi from Qualia for a deep, eye-opening conversation on longevity, healthspan, and what it truly means to stay youthful from the inside out. Dan has built an incredible reputation as a health communicator who can take complex scientific ideas and make them accessible and actionable for everyday people. And that is exactly what we dig into in this episode. We explore the difference between lifespan and healthspan and why maintaining our vitality, mobility, and mental sharpness matters more than simply adding years to the clock. Dan breaks down the reality of aging in today's world, the gaps in our current healthcare systems, and how modern stress, nutrition challenges, and lifestyle habits impact the way we age. From there, we dive into the rapidly growing field of longevity science. Dan walks us through the rise of research around senescent cells, often referred to as zombie cells, that contribute to inflammation, disease, and aging. We explore how removing these dysfunctional cells may be one of the most powerful ways to support long-term health and how Qualia's Senolytics are designed to assist that process. We also discuss the evolving landscape of stem cell therapy and how science is now supporting supplements and protocols that safely encourage the body's own regenerative processes. Dan shares how Qualia formulates their products, the level of research behind each ingredient, and the results they are seeing through human trials. This conversation is packed with practical, science-backed strategies you can start applying today to support your energy, cognition, and longevity. We also go deeper into Dan's personal journey, how he approaches productivity, and the daily practices that help him show up at his best. If you are looking to stay healthy, strong, and mentally sharp well into your later years, this episode will give you the tools and understanding to take your health seriously and make intentional decisions that support your future self. In This Episode, You Will Learn • What healthspan really means and why it matters more than lifespan • How modern lifestyles accelerate aging and what to do about it • The science behind senescent cells and how they impact inflammation and longevity • How senolytic products work and why they are gaining traction • The latest research on stem cell therapies and regenerative health • How Qualia approaches formulation and product testing • The daily habits that support cognitive performance and long-term wellness • How AI is influencing the future of health, medicine, and longevity • Why self-awareness, self-care, and expert guidance are essential for healthy aging • Dan's personal practices for productivity, growth, and wellbeing

What if longevity wasn't about adding more to your routine, but about helping your body do what it's already designed to do? Today on Rooted in Wellness, I'm joined by Dan Pardi, Chief Health Officer at Qualia Life Sciences, to explore how stem cells, cellular repair, and resilience actually work in the body. We discuss why recovery shifts as we age, the role of inflammation in slowing regeneration, and how simple lifestyle rhythms like movement, sleep in true darkness, fasting, and circadian alignment create the internal environment for healing. We also look at senolytics, autophagy, and stem cell support through a grounded, science-informed lens that feels accessible rather than extreme. This is the bridge we love on this show: emerging research meeting practical daily life. Dan Pardi leads health strategy and research at Qualia Life Sciences, where he focuses on supporting the body's natural repair systems through education, systems-level formulation, and a healthspan-first approach. His work blends emerging science with real-world application to help people feel well longer. We Also Discuss: (00:00) Why Healing Isn't Just Physical: The Emotional + Lifestyle Foundation (04:55) Resilience in Real Life: Getting Back on Track with Compassion (10:25) We Don't Age All at Once: Personalized Aging & Repair Patterns (14:08) Stem Cells 101: The Body's Built-In Repair System (20:33) What We Get Wrong About Healing (and What Actually Works) (28:28) How Stem Cells Keep Us Young—Until They Don't (33:20) Stem Cell Exhaustion: Why Recovery Slows with Age (50:14) Supporting Regeneration Without Overwhelm (58:21) The Pulse Protocol: Activating Repair, Then Resting (01:07:44) The Future of Aging: Reprogramming, Senolytics & Longevity Science (01:22:18) How to Explore Stem Cell Support Safely and Intentionally Thank You to Our Sponsors: Qualia: If you'd like to try the products Dan and I talked about, you can visit www.qualialife.com/mona and use my code MONA for 15% off. Bon charge: Bon charge: Go to boncharge.com and use the code MONA to treat yourself to this incredible mask and get 15% off today. Stress Quiz: The way you react to stress isn't random—it's rooted in your biology and lived experience. Discover your unique stress type + get a personalized healing plan to help you feel more calm, clear, and resilient. Take the quiz now:monasharma.com/quiz Learn more about Mona Sharma: Download Your FREE Guide - 12 Wellness Tips to Unlock Your Best Health Now: Ready to reclaim your vitality? Download Mona's 12 Wellness Tips and take actionable steps to transform your health, energy, and mindset. Get started now at https://monasharma.com/12tips.  Visit Mona's website: https://monasharma.com – Unlock powerful tools and wisdom rooted in wellness to elevate your health, energy, and clarity. Mona blends ancient healing practices with modern science to help you achieve lasting transformation. Follow Mona on Instagram: Stay connected with Mona for daily inspiration, holistic health tips, and personal growth. Join the conversation on Instagram at https://instagram.com/monasharma. Learn more about Dan Pardi and Qualia Facebook: https://www.facebook.com/Qualialife   Instagram: @qualialife   LinkedIn: https://www.linkedin.com/in/danpardi/

This week, I talked about the pros and cons of fasted vs. fueled exercise. They both have their pros and cons, but if you want to perform, you gotta eat. Especially women. Studies on fasted exercise were mostly done on men! Here’s some ideas of what to eat, or how and when to NOT eat. I […]

Have you ever heard of Senolytics? It's the latest breakthrough in aging and longevity science that I honestly had not heard about until learning about Qualia Senolytic. That's what I'm SO excited to welcome todays guest, naturopathic physician Dr. Gregory Kelly, the VP of product development at Qualia Life, and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. In this episode, Dr. Kelly and I discuss why you should care about cellular senescence and how its different from autophagy, the hallmarks of aging, the, and how you can age better at a cellular level by helping your body naturally eliminate senescent cells. Suggested Resources:Qualia Life (you can use the code wellnstrong for a discount!Dr. Gregory Kelly Qualia Senolytic Placebo-Controlled Clinical Study ResultsSenolytic drugs: from discovery to translationSend me a text!Kyoord makes small-batch Greek olive oils that are exceptionally rich in polyphenols—powerful compounds shown to fight inflammation, support brain health, and protect against chronic disease. It's the brand I personally use and trust daily, and you can try it yourself at kyoord.com with code WELLNSTRONG for 10% off your first order. This episode is proudly sponsored by: SizzlefishLet's talk about fueling your body with the best nature has to offer. If you're looking for premium, sustainable seafood delivered straight to your door, you need to check out Sizzlefish! Head to sizzlefish.com and use my code “wellnstrong” at checkout for an exclusive discount on your first order. Trust me, you're going to taste the difference with Sizzlefish!Join the WellnStrong mailing list for exclusive content here!Want more of The How To Be WellnStrong Podcast? Subscribe to the YouTube channel. Follow Jacqueline: Instagram Pinterest TikTok Youtube To access notes from the show & full transcripts, head over to WellnStrong's Podcast Page

Today, I'm diving solo into a topic that's both fascinating and a little bit spooky—senescent cells, also known as “zombie cells.” Understanding zombie cells is a crucial piece of the puzzle if you want to feel younger, stronger, and more resilient as you age. In this episode, I unpack what senescent cells are, why they're not just harmless bystanders, and how their buildup can accelerate the aging process and drive chronic inflammation—one of the hallmarks of aging. I break down the lifestyle habits that might be quietly increasing your zombie cell load, the early warning signs your body could be giving you, and most importantly, the evidence-backed interventions you can start using right now—from exercise and diet, to cutting-edge supplements, peptides, and more.   Episode Timestamps: What are Senescent (“Zombie”) Cells and Why They Matter ... 00:00:36 Key Causes and Lifestyle Factors Driving Senescence ... 00:02:40 Dietary Strategies: Mediterranean Diet, Protein, and Polyphenols ... 00:08:57 How Zombie Cells Disrupt Tissue and Drive Chronic Disease ... 00:13:37 Symptoms Linked to Excess Senescent Cells ... 00:20:58 Challenges in Measuring Senescent Cells ... 00:23:31 Senescent Cells: Helpful in Healing, Harmful in Excess ... 00:30:39 Senolytics and Senostatics: Drugs and Natural Compounds ... 00:36:14 Lifestyle and Supplement Strategies to Reduce Zombie Cells ... 00:39:14 Peptides for Advanced Senescence Management ... 00:48:09   Our Amazing Sponsors: Probiotic Breakthrough by Bioptimizers: uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Chapters: 00:00 Intro – Curing Aging: Science or Science Fiction?01:10 How a Father's Challenge Sparked a Lifetime Mission03:30 Why Aging Might Be a Disease06:00 Evolution & the Purpose of Aging08:30 The Discovery of Telomerase13:00 Ride-Ticket Analogy: Why Cells Stop Dividing17:30 What Telomeres Are & Why They Shorten20:00 How Telomerase Reverses Cellular Aging24:00 Lifestyle Habits that Accelerate Aging28:00 Vegan Diet, Oils, and Longevity Myths31:00 Omega-3s & Vitamin D for Telomere Health33:00 Exercise, Sugar, and Oxidative Stress38:00 Why Too Much Training Can Age You Faster41:00 Gene Therapy & Nanotech in Aging Research46:00 The Promise and Risk of Viruses in Gene Therapy49:00 Can We Live Past 125 Years?52:00 Introducing TeloVital – Plant-Based Telomerase Activator58:00 Telomeres vs DNA Methylation & Horvath Clock1:02:00 Senolytics and Why They Might Be Dangerous1:05:00 Why It's Never Too Late to Start Slowing Aging1:10:00 AI, Machine Learning & the Future of Longevity1:14:00 The Business of Curing Aging & Investor Challenges1:18:00 Best Choice Medicine & FDA Change1:22:00 Plant Medicine, Stress & Cancer Therapies1:27:00 Music Break: The Doors, Taylor Swift & BTS EndoDNA: Where Genetic Science Meets Actionable Patient CareEndoDNA bridges the gap between complex genomics and patient wellness. Our patented DNA analysis platforms and AI technology provide genetic insights that support and enhance your clinical expertise.Click here to check out to take control over your Personal Health & Wellness Connect with EndoDNA on SOCIAL: IG | X | YOUTUBE | FBConnect with host, Len May, on IG Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Steve Reiter explore various aspects of longevity, including organ age testing, the pace of aging, multi-drug gerotherapy, the role of GLP-1s, gene therapy, and the importance of lifestyle choices in optimizing health and longevity. They discuss innovative testing methods to assess organ health, the implications of aging rates, and the potential of new therapies to enhance longevity. The conversation emphasizes the significance of understanding individual health metrics and making informed lifestyle choices to achieve optimal health outcomes.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Every organ has its own age, impacting overall health. ·       Understanding organ age can help tailor longevity strategies. ·       New tests can predict health risks before they manifest. ·       Multi-drug gerotherapy offers a new approach to aging. ·       GLP-1s have benefits beyond weight loss, including heart health. ·       Gene therapy may offer new avenues for reversing aging. ·       Lifestyle factors remain crucial for longevity and health. ·       Regular sauna use significantly reduces all-cause mortality. ·       Testing and monitoring are essential for personalized health. ·       Combining therapies can enhance the effectiveness of treatments.   Chapters 00:00 Introduction to Age Hacking and Organ Age Testing 01:26 Understanding Organ Age and Proteomic Testing 07:58 The Pace of Aging and Longevity Insights 12:54 Senolytics and Multi-Drug Gerotherapy 23:53 Cleaning the System for Regenerative Therapies 25:46 Rejuvenation Factors and Supplements 26:02 Exploring GLP-1s Beyond Weight Loss 34:39 Gene Therapy and Epigenetic Reprogramming 45:36 Lifestyle Science and Hormesis   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw    

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions. Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health. Learn more about Dr. Julie Andersen and the Buck Institute: https://www.buckinstitute.org/lab/andersen-lab/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Joint aches. Softer muscles. Saggy skin. Brain fog.  Dealing with these not-so-fun issues in midlife? Trust me, you're not the only one. But… these changes aren't “just a part of getting older”. In this podcast, I'm joined by the brilliant Dr. Greg Kelly, Senior VP of Product Development at Qualia Life and a leader in anti-aging and cellular health, to unpack the powerful concept of cellular senescence, also known as “zombie cells.”  These cells don't die when they should, sticking around to cause inflammation, slow down your metabolism, and accelerate aging in your skin, joints, muscles, and brain.  The good news? You're not powerless! Dr. Kelly shares how senolytics—natural compounds that help your body clear out zombie cells—can dramatically shift how you age, supporting your body's innate ability to regenerate.  If you've been feeling like your body is betraying you, this episode will bring hope and science-backed strategies to help you feel vibrant, clear-headed, and strong again. Tune in now! Gregory Kelly N.D. Dr. Gregory Kelly is a naturopathic physician, the SVP of Product Development at Qualia Life, and the author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on PubMed. IN THIS EPISODE Enhancing longevity AND wellness in your later years  What are zombie cells, and how do they contribute to aging?  Main parts of the body impacted by zombie or senescent cells  Senolytics and how they work against zombie cells in the body  Qualia Senolytics and the science and research behind them Top non-negotiable supplements for optimal health  Enhancing women's hormonal and reproductive longevity  How to get Qualia Senolytic NOW at a discounted rate!  QUOTES “As these zombie cells accumulate wherever in our body, our joints, our skin, our brain, our muscle tissues, our fat tissues, they cause both local problems and systemic problems.”  “They scanned a whole bunch of different compounds, both plant extracts and actual medications, and came up with two that, especially when combined together, worked really well to get these zombie cells to finally go through cellular death.” “These people all had some degree of joint discomfort, and what we saw was about a 60% improvement over three dosing cycles. So this seemed like it made a big benefit.” RESOURCES MENTIONED Get your Qualia Life Senolytic at 15% off HERE!  Qualia Life Website   Qualia Life Instagram  Qualia Life YouTube Channel  Pre-order my new book: The Perimenopause Revolution HERE  RELATED EPISODES  #653: Mitochondria, Menopause & Metabolism: The Cellular Secret to More Energy After 40 with Dr. Felice Gersh #649: How To Reverse Your Biological Age + 5 Science-Backed Longevity Tips Every Woman Should Know with Leslie Kenny 640: Unveiling The Essential Role of Minerals For Cellular Energy And Detoxification with Caroline Alan 655: The Hidden Truth About Perimenopause That No One's Talking About (And Why It Changes Everything About How You Age)

  We unpack the UN Scientific Advisory Board Brief on Aging—from telomeres and epigenetic clocks

Adeline Atlas 11 X Published AUTHOR -AI + Future Technology Series: https://www.soulreno.com/ai-future-tech-series

Everyone wants to live longer and feel better, but the flood of information on supplements, drugs, and fitness can feel overwhelming.I invited Siim Land, an expert and 8-time bestselling author on longevity, to cut through the noise and share simple, evidence-based strategies that really move the needle when it comes to health and lifespan.Siim shares incredible, science-based tips on how we can enhance our healthspan and lifespan without getting lost in the hype.We dig into why exercise, especially combining strength training with cardio, is the single most powerful anti-aging tool. Siim explains how even small changes in daily activity can dramatically reduce your risk of chronic disease and help you live longer.We also talk about what everyone is curious about - Rapamycin, Metformin, Senolytics, and more - and I'm excited to share what the research really says about these popular longevity compounds. Siim also shares why having strong social relationships may be even more important than any pill.If you want clear, practical guidance on living healthier and longer, this episode is for you. Click play and join us for a deep dive into real, sustainable longevity strategies!Key Takeaways:Introduction (00:00)Siim Land's background and journey to longevity (00:30)Exercise is the top anti-aging intervention (05:31)Benefits of moderate daily activity (08:38)Importance of resistance training for muscle and metabolism (10:42)Cardiorespiratory fitness explained with heart rate zones (15:24)Thoughts on supplement overload and key supplements (26:19)Concerns about fish oil oxidation (29:06)Sunscreen vs antioxidants debate (35:53)Senolytics and longevity drugs overview (39:05)Metformin benefits (43:15)Calorie restriction and body composition for longevity (47:11)Social relationships are key to life satisfaction (50:18)Additional Resources: ✨ Connect with Siim LandBooks: https://www.amazon.com/stores/Siim-Land/author/B019H1Z14M?Instagram: https://www.instagram.com/siimland/?hl=enFacebook: https://www.facebook.com/thesiimlandYouTube: https://www.youtube.com/c/siimland—✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

These compounds are said to fight aging by clearing “zombie cells” out of your body. Is there any science to back this up?ReferencesEffects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial - PubMedA pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease - ScienceDirectJCI - Strategies targeting cellular senescenceTargeting senescent cells: approaches, opportunities, challenges - PMCTargeting cellular senescence with senotherapeutics: senolytics and senomorphics - Zhang - 2023 - The FEBS Journal - Wiley Online Library New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Diabetes and Gut Health!Have a nutrition question? Send an email to nutrition@quickanddirtytips.com. Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find Monica's blog and other programs at Nutrition Over Easy. Nutrition Diva is a part of the Quick and Dirty Tips podcast network. LINKS:Transcripts: https://nutrition-diva.simplecast.com/episodes/Facebook: https://www.facebook.com/QDTNutrition/Newsletter: https://www.quickanddirtytips.com/nutrition-diva-newsletterNutrition Over Easy: https://nutritionovereasy.comQuick and Dirty Tips: https://quickanddirtytipscom

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Zombie cells, scientifically known as senescent cells, are damaged or aged cells that refuse to die when they should. Instead, they linger in the body, releasing harmful chemicals that can trigger inflammation and accelerate aging. These cells have been linked to a range of age-related diseases, including arthritis, Alzheimer’s, and even cancer. Dive into the eerie world of 'Zombie Cells' on our latest episode! Uncover how these undead cells wreak havoc in our bodies and what cutting-edge research reveals about their role in aging and disease. Today on The Lab Report: 4:15 Cell turnover, apoptosis, and autophagy vs. zombie cells 7:30 What triggers zombie cells to form and what are telomeres? 10:15 Age-related diseases and inflammation 12:15 Senolytics and strategies to clear zombie cells 17:30 Just practice naturopathic medicine 18:30 Rules to survive a zombie apocalypse Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

BUFFALO, NY — April 1, 2025 — A new #research paper was #published in Aging (Aging-US) on March 29, 2025, as the #cover of Volume 17, Issue 3, titled “Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer's disease.” In this study, a research team from Dalhousie University, led by Sultan Darvesh, discovered that certain anti-aging compounds, known as senolytics, can block harmful brain enzymes linked to Alzheimer's disease (AD) without affecting healthy ones. Senolytics are compounds that help clear out damaged or “zombie” cells that build up with age and contribute to inflammation and tissue dysfunction. This work provides new insight into how AD-related damage can be precisely targeted, leading the way for safer treatments that protect memory and brain health in older adults. Alzheimer's disease is one of the most common causes of memory loss and dementia. A hallmark of the disease is the buildup of sticky protein clumps in the brain, known as amyloid-beta plaques. Two enzymes—acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)—are found near these plaques. While these enzymes play important roles in brain function, they can also contribute to AD progression when they attach to plaques. Drugs that target these enzymes are already used to help with memory, but they often block both harmful and healthy forms, which can cause unwanted side effects. To investigate a better solution, researchers tested six compounds that are known for their anti-aging or brain-boosting properties. They wanted to know if these compounds could block only the harmful AChE and BChE enzymes forms linked to Alzheimer's disease. Using brain tissue samples from AD patients and enzyme activity assays, they discovered that compounds such as dasatinib and nintedanib, both senolytics, were able to block the forms of AChE and BChE associated with amyloid-beta plaques. These compounds did not affect normal brain enzymes, though. “We show that the selected senolytics and nootropic inhibit ChEs associated with plaques but not the enzymes associated with normal neural elements.” The study also used computer modeling to explore how these compounds interact with the enzymes. The models showed that the enzymes change shape when near plaques, making them easier for certain compounds to target. This change may explain how the drugs can selectively affect only the diseased areas of the brain. While not all compounds worked equally well, the findings offer a new strategy for treating AD. By focusing on the differences between healthy and diseased enzyme forms, researchers may be able to design more precise and effective therapies. This selective approach could improve memory, reduce inflammation, and avoid the side effects of AD's current treatments. In summary, this research opens new possibilities for treating Alzheimer's disease in a more targeted way. It also highlights how discoveries in aging and brain health can work together to create better therapies for neurodegenerative diseases. DOI - https://doi.org/10.18632/aging.206227 Corresponding author - Sultan Darvesh - sultan.darvesh@dal.ca Video short - https://www.youtube.com/watch?v=CJQFpG9Jn6Y Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206227 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Biohacking for Longevity: Extending Your Health Span. In this episode of "Leyla Weighs In," registered dietician and nutritionist Leyla Muedin discusses the concept of biohacking and its potential to extend lifespan and health span. Leyla explores various biohacking strategies such as diet optimization, regular physical activity, stress management, enhancing sleep quality, and maintaining strong social connections. She emphasizes the importance of epigenetics, targeted lifestyle changes, and advanced medical interventions like stem cell therapy. You will learn practical biohacking tips, including the benefits of intermittent fasting, the significance of exercise, and how to use wearable technology for health tracking. Leyla also highlights the role of supplements and personalized nutrition in promoting longevity, alongside maintaining good dental health and a sense of purpose. Through these combined efforts, Leyla aims to inspire listeners to not only live longer lives but to enjoy better health and vitality.

Christian Asare, MD, joins Integrative Practitioner Content Specialist Avery St. Onge to discuss the connection between chronic pain, aging, and cellular senescence in a live interview at the 2025 Integrative Healthcare Symposium. About the Expert Asare B. Christian, MD, MPH, is a board-certified integrative and regenerative pain management specialist and the founder of Aether Medicine in Wayne, Mainline Philadelphia. Aether Medicine focuses on cellular health to alleviate pain, enhance performance, and extend healthspan. Dr. Christian integrates various medical disciplines, including pain management, cellular medicine, neurorehabilitation, and longevity medicine, with personalized lifestyle modifications. His approach is characterized by empathetic patient care and a profound understanding of medical science, tailored to individual health solutions.

Support the show and get 50% off MCT oil with free shipping – leave us a review on iTunes and let us know!Aging isn't just about the years you accumulate—it's about how well your body holds up along the way. According to Dr. Gregory Kelly, the key to longevity isn't just diet and exercise—it's eliminating the "zombie cells" that could be making you age faster than you should.Dr. Kelly is a naturopathic physician, author, and a leading researcher on senolytics—the compounds that target senescent cells (aka zombie cells) to improve health and extend lifespan.In this episode, Dr. Kelly shares why these "zombie cells" linger in our bodies, how they contribute to chronic inflammation, and what you can do to clear them out. He also breaks down the latest research on senolytics, the connection between cellular aging and joint pain, and why intermittent dosing could be the key to unlocking better health as you age."The zombie analogy is used so much because they're not alive, they're not dead, and they can create new versions of themselves that are also not alive and not dead." ~ Dr. Gregory KellyAbout Dr. Gregory Kelly:Dr. Gregory Kelly is a naturopathic physician and lead researcher at Neurohacker Collective. He has published extensively on natural medicine, nutrition, and the science of aging. His expertise spans from engineering to Southeast Asian studies and naturopathic medicine, giving him a unique perspective on longevity and human health.Resources Mentioned:Qualia Senolytic: https://www.qualialife.com/livebeyond Connect with Dr. Gregory Kelly:- Qualia Website: https://www.qualialife.com/ - Qualia X: https://x.com/qualialifeco - Instagram: https://www.instagram.com/qualialife/ - YouTube: https://www.youtube.com/neurohacker - Podcast: https://podcasts.apple.com/us/podcast/collective-insights/id1293899173 Connect with Chris Burres:- Website: https://www.myvitalc.com/ - Website: http://www.livebeyondthenorms.com/ - Instagram: https://www.instagram.com/chrisburres/ - TikTok: https://www.tiktok.com/@myvitalc - LinkedIn: https://www.linkedin.com/in/chrisburres/ 

In this sponsored interview, Andrea Donsky, nutritionist, menopause educator, published menopause researcher, and co-founder of Morphus, discusses senolytics with Dr. Gregory Kelly - Director of Product Development at Qualia Life Sciences, naturopathic physician, and author of "Shape Shift."Women in perimenopause and menopause should explore the benefits of senolytics for cellular aging because of the impact on their menopausal symptoms and overall health. During menopause, there's an accelerated accumulation of senescent cells (zombie cells) in the body, which can trigger inflammation, joint pain, and other age-related issues that make menopausal symptoms more challenging to manage. Understanding these changes helps women take steps to help them feel better and improve their long-term health. Senolytics are used only a couple of days a month, but the benefits can be felt, especially as shown by the studies done on joint pain.Key Points:Explore how cellular aging affects women during perimenopause and menopause.When cells have trouble producing energy and the body's repair cells decline, menopausal symptoms can become more severe.Discover what senescent cells ("zombie cells") are and why they accumulate more after menopause.Learn how senolytic compounds can help remove accumulated senescent cells contributing to joint pain and other issues.Understand why an intermittent approach to senolytics (2 days per month) is more effective than daily supplementation.Get practical tips for using senolytics safely and effectively during your menopause journey.Save 15% on Qualia Life Senolytics https://bit.ly/42mtvmx CODE MORPHUS15Follow Qualia Life on Instagram https://www.instagram.com/qualialife?igsh=anBzMXVkazViN3NyDr. Gregory Kelly's Book: Shape Shift: The Shape Intelligence Solution https://amzn.to/42RCbkSSend us a text ✅ Fill out our surveys Support our SPONSORS: Qualia https://bit.ly/42mtvmx CODE MORPHUS15 BEAM Minerals https://bit.ly/41DCG1w Code MORPHUS EnergyBits https://bit.ly/49f05YV Code MORPHUS Livon: https://bit.ly/3EjrcGG CODE MORPHUS Order 1 carton of Lypo-Spheric® Vitamin C at LivOnLabs.com & get 1 carton of B Complex Plus FREE ($56 value) just by adding both products to the cart Timeline: timeline.com/morphus CODE MORPHUS

Subscribe to our channel: https://www.youtube.com/@optispan In this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of personalized medicine in aging research, emphasizing the need for careful interpretation of scientific data. 00:00:00 - Should Matt be skeptical of the 40% life extension figure for caloric restriction? 00:06:43 - Can calorie restriction be combined with other interventions like Rapamycin or Senolytics? 00:11:30 - Does metformin or berberine have significant effects on longevity? 00:14:51 - Is pea protein powder a good dietary choice for a complete protein? 00:17:33 - What are the best ways to increase VO2 max? 00:20:12 - Longevity Fads? 00:22:45 - How does cold exposure affect inflammation? 00:26:05 - How does NAD+ supplementation compare to NMN for longevity? 00:29:11 - What role does sleep quality play in overall lifespan? 00:32:00 - Can mindfulness or meditation improve biomarkers related to aging? 00:35:22 - Is there evidence that probiotics can extend lifespan? 00:38:45 - How does alcohol consumption affect aging and longevity? 00:41:10 - What are the best supplements for improving cognitive health with age? 00:45:00 - Are there specific dietary patterns proven to slow biological aging? 00:48:25 - How effective is Rapamycin when started later in life? 00:52:10 - Can exercise offset the negative effects of a poor diet? 00:55:34 - Is there a link between gut health and lifespan? 00:58:20 - What are the biggest misconceptions about anti-aging interventions? 01:06:33 - Do you track fiber intake? 01:07:45 - What's the common misconception about mTOR? 01:09:33 - Are there ongoing studies comparing rapamycin to other mTOR inhibitors in terms of safety and effect? 01:11:48 - Favorite band? 01:11:52 - How can a non-scientifically trained person tell good science from bad? Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/

Angela presents the second of a two part conversation with Dr Gregory Kelly, in which they discuss the intriguing topic of senescent cells, often referred to as "zombie cells." These cells accumulate with age, resist apoptosis, and contribute to inflammation, negatively impacting overall health and vitality. Dr. Kelly explains the mechanisms behind cellular senescence and introduces the concept of senolytics—compounds designed to help clear these dysfunctional cells from the body KEY TAKEAWAYS Senescent cells, often referred to as "zombie cells," resist apoptosis (cell death) and accumulate with aging. They do not contribute to bodily functions and instead release inflammatory compounds that can lead to various age-related health issues. Senolytic compounds are designed to help clear out senescent cells from the body. By periodically taking these compounds, individuals can promote cellular health and potentially improve energy levels, joint comfort, and overall vitality. The process of using senolytics can be likened to pruning yellow leaves from a plant. Just as removing unhealthy leaves allows for new growth, clearing out senescent cells can help rejuvenate tissues and promote healthier cellular function. It is suggested that individuals start considering senolytics around the age of 40, especially if they have experienced significant stress or health issues. Younger individuals may not need to use them as frequently, while older adults may benefit more from regular use. BEST MOMENTS "Senescent cells resist cell death, are unrepairable, and secrete inflammatory compounds, contributing to aging and various health issues."  "If exercise was a pill, everyone would take it because it stimulates autophagy and helps slow the accumulation of senescent cells."  "Senolytics are compounds that can finally get a senescent cell to change its mind and go through this falling off process."  "If we want a different result than our parents or grandparents, we have to start doing more and start doing it younger." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community Save 15% on Qualia Mind with Code ANGELA15 at http://www.qualialife.com/angela Check out Leela Quantum Technology and save 10% with code ANGELA at www.leelaq.com ABOUT THE GUEST Dr. Gregory Kelly is a naturopathic physician (N.D.). He is Vice President of Product Development at Qualia Life Sciences and author of the book Shape Shift. He was an editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Nutrition and Counseling Skills. Dr. Kelly has published numerous articles on various aspects of natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of special interest and expertise include nootropics, anti-aging and regenerative medicine, weight management, and the chronobiology of performance and health. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Six conditions cause the majority of deaths in the world, these include dementia and cardiovascular disease. Traditionally, we've looked at these conditions through the lens of what goes wrong individually, such as blocked arteries around the heart or tangles of proteins that impair electrical signalling in the brain. But the common denominator is actually ageing.As grandiose and esoteric as that sounds, ageing and the processes that govern ageing are what we need to be tackling if we want to better manage or even prevent these conditions of older age.And with me to discuss why and how we age is Richard Faragher. He's Professor of Biological Gerontology at the University of Brighton, and has dedicated his career to understanding the ageing process and what we can do to improve this inevitable phase of life.As you can tell from today's episode, Richard is a passionate advocate for older people and can wax lyrical about the history of the gerontology field.A few definitions before we dive into the episode I think will be helpful for people who are new to the research.There are agreed “hallmarks” of ageing that are a description of processes, such as metabolism and DNA repair functions, that go awry as we grow older. Ageing is caused by these changes at the molecular level that lead to downstream effects like disease and degeneration.Cell senescence is what happens at the end of a cell's lifespan, where they become dysfunctional and need to be removed by immune cells. However in older age, it can become more troublesome for your immune system to clear away these senescent cells and increasing inflammation ensues.Senolytics are compounds or drugs that have been designed to selectively eliminate these senescent cells. And the hope is that they can mitigate a range of age-associated conditions like arthritis, cataracts, dementia and more.Trigger warning. We discuss a graphic analogy for senescent cells using suicide, so I just wanted to give a heads up for anyone who might find that analogy uncomfortable.

Send me a text!Have you ever heard of Senolytics? It's the latest breakthrough in aging and longevity science that I honestly had not heard about until learning about Qualia Senolytic. That's what I'm SO excited to welcome todays guest, naturopathic physician Dr. Gregory Kelly, the VP of product development at Qualia Life, and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. In this episode, Dr. Kelly and I discuss why you should care about cellular senescence and how its different from autophagy, the hallmarks of aging, the, and how you can age better at a cellular level by helping your body naturally eliminate senescent cells. Suggested Resources:Qualia Life (you can use the code wellnstrong for a discount!Dr. Gregory Kelly Qualia Senolytic Placebo-Controlled Clinical Study ResultsSenolytic drugs: from discovery to translationQualia Senolytic combines 9 vegan, plant-derived compounds to help your body naturally eliminate zombie (or senescent) cells, that help us age better at the cellular level so we can feel YEARS younger! Use the code WELLNSTRONG for 15% off!Join the WellnStrong mailing list for exclusive content here!Want more of The How To Be WellnStrong Podcast? Subscribe to the YouTube channel. Follow Jacqueline: Instagram Pinterest TikTok Youtube To access notes from the show & full transcripts, head over to WellnStrong's Podcast Page

Hey everyone.Today, I've got a fantastic guest on the show - Dr. Gregory Kelly from Neurohacker Collective. You may have heard of them from their game-changing supplements, but today, we're going beyond the bottle. We're getting into the fascinating world of senolytics, talking about ageing intelligently, and exploring whether you might be a ‘super responder' - and trust me, that's a good thing! Dr Gregory is not only a brilliant naturopathic doctor and an author, but he's also a great storyteller with some incredible insights to share. You're in for a treat with this one. Let's get right into it!Highlights:(3:47) Dr. Kelly's journey to naturopathic medicine (7:54) Qualia and the concept of senolytics (21:11) The development of qualia senolytic (27:31) The role of senolytics in health and ageing (54:46) The future of senolytics and health research (55:33) Dr. Kelly's philosophy on health and wellness Find out more about Dr Gregory Kelly:Website - LinkedIn - Instagram - Facebook - TwitterVisit Nicole's on demand fitness platform for live weekly classes and a recorded library of yoga, strength training, guided audio meditations and mobility (Kinstretch) classes, as well: https://www.sweatandstillness.comGrab Nicole's bestselling children's book and enter your email for A FREE GIFT: https://www.yolkedbook.comFind Nicole on Instagram:https://www.instagram.com/nicolesciacca/Tik Tok: https://www.tiktok.com/@thenicolesciaccaFacebook: https://www.facebook.com/nicolesciaccayoga/Youtube:https://www.youtube.com/channel/UC1X8PPWCQa2werd4unex1eAPractice yoga with Nicole in person in Santa Monica, CA at Aviator Nation Ride. Get the App to book in: https://apps.apple.com/us/app/aviator-nation-ride/id1610561929Book a discovery call or virtual assessment with Nicole here: https://www.calendly.com/nicolesciaccaThis Podcast is Proudly Produced by The Podcast BoutiqueMentioned in this episode:www.Neurohacker.com/shockandyall and use the code SHOCKANDYALL to get 15% off your first order

My guest in this cutting edge episode is Greg Kelly from Qualia Senolytic. Greg will be diving into cellular senescence – and together we're unveiling the secrets behind reversing age. Why? Because with the latest studies and emerging research, it's clear that tackling senescent cells could be a game-changer in the quest to slow down the aging process. These "zombie" cells don't just age us, they wreak havoc on our health, setting the stage for age related issues. And believe me, I was as curious as anyone about how we could possibly combat these senescent cells until we started peeling back the layers. It turns out, the answer might be senolytics – natural and pharmaceutical compounds showing promise in eliminating these problematic cells. We're talking about quercetin, fisetin, and other potent allies that can pave the way for healthier, longer lives. So, we're here to pass on this crucial information to you – chew on it, see where it fits, and maybe get started on your own journey of age reversal. Connect with Qualia Senolytic: http://neurohacker.com/thyroid Use the code THYROID for 15% off your order Shop ALL of Dr. Amie's Fixxr® Supplements: betterlifedoctor.com LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free application call: https://dramiehornaman.com/pages/book-a-call FREE DOWNLOADS… What Are the Optimal Lab Ranges? What Steps Can I Take? Don't know where to start...don't know which labs are useful? And what to do when you get your results? “How To” Guide For Supplements Here's your Fixxr® supplement timeline and guide. Fix Your Thyroid and Adrenals To Fix Your Life Check your symptoms of hypothyroidism and know OPTIMAL thyroid lab values. Learn why you are being told you're “NORMAL” by your doctor. Can Supplements Help with Hypothyroidism? Grab this thorough guide to help you select the most advantageous supplements that will best suit your health circumstances. RATE, REVIEW AND FOLLOW ON APPLE PODCASTS Show your love for Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE, scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review. Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group, Dr. Amie…The Thyroid Fixer®...Love Your Mirror, for a Community of HOPE and Support in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine Subscribe on Youtube: Dr. Amie Hornaman Follow me on Instagram: @dramiehornaman

Are you curious about the science behind aging and how to potentially slow it down?Aging gracefully and maintaining a vibrant, healthy life is a universal desire, and in this episode of The Biohacking Bestie podcast, I talk with Dr. Gregory Kelly about the secrets to achieving just that. Dr. Greg Kelly is a leading expert in the field of aging and senescent cells, and we discuss how we can extend not just our lifespan but our health span too. We also dive into the 12 hallmarks of aging, the power of senolytic compounds, the innovative supplements from Qualia, which are backed by rigorous research, and more. Gregory Kelly is Director of Product Development at Neurohacker Collective, a naturopathic physician (N.D.), and the author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed.Listen as we discuss…(00:01) Understanding Senescent Cells and Aging(10:56) Senescent Cells and Aging Interventions(19:43) Senolytics(25:59) Optimal Timing for Senolytic Supplementation(34:56) Senolytics and Aging Implications(49:50) New Innovation in Natural Supplements(55:29) Exploring Qualia Life Supplements… and more! Grab my brand-new book: Biohack Like a Woman. Order now on Amazon: http://bit.ly/3TYMz5Z Find more from Aggie: Start optimizing your health here: https://biohackingbestie.com/Get daily Biohacking Bestie tips here: https://www.instagram.com/biohackingbestie/Get a 7-Day FREE meal plan here: https://www.fitasfuck.co/mealplanFind more from Dr. Greg Kelly:Website: https://www.qualialife.com/people/greg-kelly Instagram: @qualialifeHosted on Acast. See acast.com/privacy for more information. Hosted on Acast. See acast.com/privacy for more information.

I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis. Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you're using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Alessandra Zonari, PhD OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin's biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals. Email: alessandra@oneskin.co THANKS TO OUR SPONSOR OneSkin: Website PROMO Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website SHOW NOTES Animated science video explaining how OS-01 works Another Study Website Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website MolClock: Estimate DNA methylation age of Skin Tissues Study Website Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

In this episode of the Wild Health Podcast, Dr. Mike Mallin sits down with Dr. Gregory Kelly to explore the fascinating world of cellular senescence and senolytics. Cellular senescence, a state where cells cease to divide and function properly, is a critical aspect of aging. Dr. Kelly delves into the mechanisms behind senescence, the impact of senescent cells on our health, and the groundbreaking potential of senolytics—compounds designed to selectively target and eliminate these "zombie cells." Join us as we cover: The basics of cellular senescence and why it matters. The dual theories of aging: programmed aging vs. damage accumulation. The discovery and evolution of senolytics, from early genetic modifications in animals to the latest research on compounds like quercetin and fisetin. The mechanisms by which senolytics work and their role in promoting cellular health. Practical insights into how senolytics can be used, including the importance of dosage and the concept of "hit and run" dosing. The story behind Neurohacker Collective's Qualia Senolytic, a supplement designed to harness the power of senolytics for improved joint health, energy, and overall wellness. Whether you're a health enthusiast or simply curious about the latest advancements in longevity science, this episode is packed with valuable information and actionable insights. Tune in to learn how you can take control of your aging process and enhance your health span with the power of senolytics. Visit neurohacker.com/wildhealth and use the code wildhealth for 15% off Qualia Senolytic and other cutting-edge health products.

Do you know what senescent (zombie) cells are and how cellular senescence and senolytics impact health? In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. This episode is a deep dive into aging research, cellular senescence, and senolytics. Dr. Kirkland discusses the impact of cellular aging (senescence) on healthspan and his discovery of the first senolytic agents that remove senescent cells and extend healthspan, illuminating his pioneering work in aging research.Dr. Kirkland shares insights into the science of cellular senescence and how selectively eliminating these cells could revolutionize the treatment of age-related chronic diseases. He sheds light on the mechanisms behind senolytics and their promise for extending healthspan. The discussion also touches on the importance of lifestyle factors like diet and exercise in managing senescent cells. Dr. Kirkland also discusses geroscience, a research paradigm that seeks to understand the mechanisms of aging and how this knowledge can be used to slow the rate of aging, reverse its effects, delay or even cure age-related diseases, and extend healthspan. T Dr. Kirkland also covers the challenges and opportunities in translating these scientific discoveries into clinical applications, emphasizing the critical role of interdisciplinary efforts in advancing our understanding and management of aging.This is an enlightening episode with Dr. Kirkland on aging research and the opportunities to revolutionize healthcare by combating aging-related diseases and extending people's health span and lifespan.Timestamps:Introduction: 00:00-03:49What led Dr. James Kirkland to become a physician-scientist and become interested in aging research?: 03:50-05:24What is geroscience, and what are fundamental aging processes?: 05:25-09:17What are the differences between targeting aging vs. the traditional medical system of waiting to treat illnesses or diseases after they occur?: 09:18-12:39What are gerotherapeutics, and what is their relevance for healthspan and lifespan?: 12:40-16:10What are senescent cells? What is the impact of senescent cells on the body and aging: 16:11-26:39What are senolytics? How do senolytics work to target senescent cells to remove them?: 26:40-35:05How Dr. James Krikland discovered senolytics such as fisetin, quercetin, and dasatinib? What clinical trials on the effects of senolytics in humans have been done? 36:06-40:47Discovering biomarkers for senescent cells: 40:48-42:37What are some important factors to consider on the effects of gerotherapeutics and senolytics on lifespan and healthspan in model organisms compared to humans?: 40:38-47:39The potential for geroscience and gerotherapeutics, such as senolytics, to transform healthcare. What is the importance and what are some challenges of conducting clinical trials on gerotherapeutics, such as senolytics, to improve healthspan in humans?: 47:40-56:15What is the Translational Geroscience Network, and what are its goals?: 56:16-01:02:01How might senolytics be used clinically in the future if proven safe and effective? What conditions might they benefit?: 01:02:02–01:05:57What are the effects of lifestyle, such as diet and exercise, on senescent cells?: 01:05:58-01:06:52What excites Dr. James Kirkland the most about the potential for extending people's healthspan and lifespan with therapies, drugs, or interventions in the coming years?: 01:06:53-01:07:41Dr. Kirkland's top tip for health? 01:07:42-01:12:14

Join me as I sit down with the insightful Dr. Greg Kelly from Neurohacker Collective to unpack the complexities of aging and brain health. Listen in as we explore the intriguing theories behind why we age – is it a programmed deterioration or an accumulation of cellular damage? Dr. Kelly shares his expertise on how lifestyle choices impact our cellular vitality and introduces us to the concept of cellular senescence. Go to neurohacker.com/REALFOODOLOGY for up to $100 off and use code REALFOODOLOGY at checkout for an additional 15% off.  Topics Discussed: 0:10:55 - Supplement Stacking Options 0:13:54 - Cellular Senescence and Aging Process 0:22:08 - Understanding Senescent Cells in Aging 0:27:11 - Senolytics & Cellular Rejuvenation 0:30:57 - Targeting Senescent Cells for Healthy Aging 0:38:28 - Individual Responses to Supplements 0:42:58 - Benefits of Quality Supplements and Probiotics Sponsored By: Neurohacker Go to neurohacker.com/REALFOODOLOGY for up to $100 off and use code REALFOODOLOGY at checkout for an additional 15% off.  Check Out Courtney: @realfoodology My FREE Grocery Guide Leave Me a Message! Air Dr Air Purifier AquaTru Water Filter Produced By: Drake Peterson Edited By: Mike Frey

Dr. Nick Bitz is a Naturopathic Physician who specializes in Ayurvedic medicine. He is an expert in the natural products industry and is the Senior VP of Product Development at Neurohacker Collective. His expertise includes nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements.In our latest dialogue, we delve into the ancient art of Ayurvedic medicine. Imagine a life where your unique body type is the compass that guides every health and wellness decision you make. Through our in-depth discussion, you'll discover the foundations of Ayurveda and how tapping into the Kapha, Pitta, and Vata doshas can be the key to unlocking a vibrant, balanced lifestyle. Dr. Nick reveals how you can weave these time-tested principles into your modern life.Dive into the heart of Ayurveda with us and grasp how the language of Sanskrit connects us to the universe, how Ayurvedic philosophy transcends diet to touch every aspect of our lives, and how understanding your dosha can shape your path to well-being. I illuminate the importance of aligning lifestyle choices with your body's needs with personal anecdotes and practical advice. We touch on the synergy of Ayurveda and yoga, the therapeutic cadence of "ohm," and how practices like pulse diagnosis can offer insights into your health that transcend what any online questionnaire can provide.To try Neurohacker's highly advanced and researched products, go to https://neurohacker.com and use my code SANDYK for a discount.Past Episodes with Dr. Nick and Neurohacker:Episode 162 on Senolytics & Aging:  https://podcasts.apple.com/ca/podcast/sandy-k-nutrition-health-lifestyle-queen/id1496677282?i=1000612129322Episode 203 on Gut Health:  https://podcasts.apple.com/ca/podcast/sandy-k-nutrition-health-lifestyle-queen/id1496677282?i=1000643338637This podcast episode is sponsored by Sigrid Glucose Stabiliser.  Sigrid Blood Glucose Stabiliser:  Go to https://sigridstabiliser.com/  and use code SandyK15 for a discount.My Essential Thyroid Guide is now available on all Amazon stores!US:  https://www.amazon.com/dp/B0CW4X3WJDCanada:  https://www.amazon.ca/dp/B0CW4X3WJDSupport the showPlease remember to subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgTwitter: https://twitter.com/sandyknutrition

Everyone wants to slow down the signs of aging, but very few people are going about it the right way. The negative aspects of aging are one of the most ubiquitous challenges to quality of life. However, one thing is for sure: scientists believe that a big part of the reason we experience aging the way we do is because of stressed or worn-out cells called senescent cells. Senolytics is a term used to describe ingredients shown to help decrease these damaging senescent cells.  My guest on this show - Gregory Kelly - has helped to develop several rare and powerful compounds that have scientifically shown senolytic activity, and which collectively cover a broader range of mechanisms than existing senolytic supplements on the market. His protocol, which we discuss on this show, involves a two-day rejuvenation regimen that he suggests using every month. Intermittent short-duration dosing is the most common way that senolytics are used in studies, and data suggests that it can take weeks for senescent cells to re-accumulate in the body, which is why Greg recommends this approach. Greg's compound is called "Senolytic" and made by my friends at Neurohacker Collective. For the full episode page and shownotes, visit: https://bengreenfieldlife.com/senolytic Episode sponsors: Organifi (Red): Recharge your mind and body with a delicious superfood berry blend of premium, organic superfoods that contain potent adaptogens, antioxidants, and a clinical dose of cordyceps. Increase energy and boost nitric oxide levels with zero caffeine and only 2 grams of sugar. Go to organifi.com/Ben for 20% off your order. Seed: If you're taking supplements, but not a probiotic, you might be overlooking your gut—which affects your whole-body health. If you want to add a probiotic + prebiotic to your daily routine, use code BEN15 at seed.com/ben to redeem 15% off your first month of Seed's Daily Synbiotic. Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go Joovv.com/ben and apply code BEN. Element Health CBD: Full-spectrum CBD and by far the most potent stuff on the market. If you're dealing with sleeping problems, anxiety, or stress, you got to try it. It's been a game changer for me. Go to elementhealthsupply.com/ben and use code BEN15 for 15% off your entire order. Boundless Parenting Book: Everything you need to know about family, parenting, and raising healthy, resilient, free-thinking and impactful children. Go to boundlessparentingbook.com and pre-order your copy now. BGL CAREERS: Check out our open positions at BenGreenfieldLife.com/Careers. Shine Sedona: Join my family and me in Sedona Arizona from March 10-12, 2023 at an amazing event hosted by SHINE. I'll be giving a keynote talk on breathwork and biohacking, and hosting a VIP Greenfield-style home-cooked dinner prepared by my family. For tickets to the Shine Event where I'll be a keynote speaker visit bengreenfieldlife.com/shinesedona.  To book your spot for our VIP dinner visit bengreenfieldspeaking.com/sedona-dinner.   

IN THIS EPISODE OF THE HUMAN UPGRADE™… you'll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that's still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It's the quality of your close relationships that matters.Good close relationships don't just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You'll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don't be dragged down.)what social fitness is and how to practice it. (Yes, it's a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)Watch this episode on YouTube!Don't Miss This! Dr. Waldinger's TEDtalk about the study is one of TED's Top 10 episodes and viewed more than 43 million times.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Energize Your Brain & Body: https://nootopia.com/davegenius, use code DAVE10 to get an extra 10% offClear Out Zombie Cells with Senolytics: https://neurohacker.com/dave, code ASPREY to get an additional 15% off9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You'll learn from dozens of experts at an amazing event that's designed to upgrade every area of your life.https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neurohacker Collective sponsored this episode.IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADE™… you're going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he's director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee. Watch this episode on YouTube!9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You'll learn from dozens of experts at an amazing event that's designed to upgrade every area of your life. https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™…… Steven Gundry, M.D., explains that ketones aren't the fat-burning molecules you think they are. Ketones actually work to enhance health, weight loss, and longevity by acting as signaling molecules that stimulate your mitochondria. A cellular process known as “mitochondrial uncoupling” happens. He debunks common myths about keto in his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,” and shares eight “keys” that unlock the keto code: Intermittent fasting or time-controlled eating PolyphenolsDietary fiber Fermented foods PolyaminesCold temperaturesHot temperaturesRed light therapyUpgrading your nutrition with keto gets even simpler in this conversation that gives you real food examples of how to ignite your mitochondrial uncoupling process without a monotonous, limiting, high-fat diet.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get 30% off products at https://gundrymd.com. Use code DAVE30 at checkout.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Clean up Zombie Cells with Senolytics: https://neurohacker.com/dave, use code Asprey15 to save 15%Cooler Temps for Deeper Sleep: https://www.chilisleep.com/, use code HUMANUPGRADE20 to save 20% on the Dock Pro Sleep System. Learn more: Upgrade Spotlight: Improve Your Sleep With a Cooler Body Temp – ChiliSleep – #923Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.