Podcasts about autoimmune disorders

Episode Summary: Have you ever found yourself saying yes when you really wanted to say no? Or have you ever felt overwhelmed and exhausted because you were trying to meet everyone else’s expectations? If so, you are not alone. In recognition of National Stress Awareness Day, today, we’re going to explore how to move from overwhelmed to overjoyed by learning to say no without feeling guilty. We’ll dive into Scripture, explore research on overcommitment, and I’ll share five practical ways to set God-honoring boundaries. Quotables from the episode: Many of us, especially as women, have been taught that saying yes is the godly thing to do. We associate busyness with productivity, and productivity with worth. But the truth is, constantly saying yes can leave us drained, distracted, and distant from God’s best for us. For many years, I said “Yes” every time something was asked of me because I believed it was the godly response. Until God impressed upon my heart that he never told me to do that much, and had I sought him for wisdom, He would have readily guided my path! That was totally on me, but God was so gentle in getting my attention. Psychologists have long studied the effects of people-pleasing and overcommitment. Research from the American Psychological Association shows that chronic overcommitment leads to stress, anxiety, and even depression. Emotionally, people-pleasers often struggle with self-worth, believing their value is tied to what they do for others rather than who they are in Christ. Chronic Overcommitment and Overwhelm Chronic overcommitment and overwhelm can take a serious toll on physical health, leading to conditions such as: Adrenal Fatigue & Hormonal Imbalance – Constant stress can dysregulate cortisol levels, leading to exhaustion, brain fog, and difficulty managing emotions. Cardiovascular Issues – Chronic stress increases blood pressure, heart rate, and inflammation, raising the risk of heart disease, hypertension, and stroke. Weakened Immune System – Prolonged stress suppresses immune function, making the body more susceptible to infections and slower to heal. Gastrointestinal Problems – Overwhelm can contribute to acid reflux, irritable bowel syndrome (IBS), ulcers, and digestive issues. Chronic Pain & Inflammation – Stress triggers inflammation, which can exacerbate conditions like fibromyalgia, arthritis, and migraines. Sleep Disorders – Overcommitment often leads to insomnia, poor sleep quality, and chronic fatigue. Weight Gain or Loss – Stress-related eating patterns can lead to unhealthy weight fluctuations, metabolic dysfunction, and insulin resistance. Muscle Tension & Headaches – Persistent stress can cause tight muscles, tension headaches, and even TMJ (jaw pain from clenching). Burnout & Mental Fog – Long-term overwhelm can impair cognitive function, reducing focus, memory, and decision-making ability. Autoimmune Disorders – Chronic stress has been linked to the development or worsening of autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis. Managing stress through rest, boundaries, and self-care isn’t just about mental well-being; it’s essential for physical health. Jesus himself set boundaries. In Luke 5:16, we read, “But Jesus often withdrew to lonely places and prayed.” He didn’t heal every person or meet every need. He sought the Father’s will first. If Jesus set boundaries, then we should, too. Addressing the spiritual and scientific aspects of restoration To counteract the physical effects of chronic overcommitment and overwhelm, we must address both the spiritual and scientific aspects of restoration. Here’s how: Prioritizing Rest & Sabbath (Biblical & Scientific) Biblical Insight: God modeled rest in Genesis 2:2-3, and Jesus regularly withdrew to quiet places (Mark 6:31). Sabbath isn’t just a suggestion; it’s a command for our well-being (Exodus 20:8-10). Science: Rest lowers cortisol, improves immune function, and enhances brain health. Sleep is crucial for memory consolidation and physical repair. Application: Schedule intentional rest. Guard your Sabbath. Ensure 7-9 hours of sleep. Setting Boundaries to Prevent Overcommitment Biblical Insight: Even Jesus set boundaries—He didn’t heal everyone at once and took time alone with the Father (Luke 5:16). Proverbs 4:23 reminds us to guard our hearts, which includes protecting our time and energy. Science: Chronic stress leads to burnout, weakened immunity, and heart disease. Learning to say “no” prevents emotional and physical depletion. Application: Use discernment in commitments. Before saying “yes,” ask: Does this align with God’s will? Is this sustainable? Engaging in Mind-Body Renewal Biblical Insight: Romans 12:2 encourages us to renew our minds. Philippians 4:8 tells us to focus on what is pure and lovely. Science: Practices like deep breathing, exercise, and gratitude shift the brain out of stress mode, improving mental clarity and resilience. Application: Try breath prayers (e.g., inhale “Be still,” exhale “and know that I am God”; inhale “I trust you, God,” exhale “in all things.”). Move daily to reduce inflammation and boost mood. Nourishing the Body & Mind Biblical Insight: Daniel chose healthy foods and was stronger than those indulging in excess (Daniel 1:12-15). Our bodies are temples of the Holy Spirit (1 Corinthians 6:19-20). Science: Whole foods reduce inflammation, regulate blood sugar, and protect against stress-related illnesses. Application: Eat nutrient-dense foods, stay hydrated, and avoid excess caffeine or sugar that heightens stress responses. Seeking Community & Support Biblical Insight: Ecclesiastes 4:9-10 teaches that two are better than one. We weren’t designed to carry burdens alone (Galatians 6:2). Science: Social connection lowers stress hormones, strengthens immunity, and increases resilience. Application: Surround yourself with godly counsel. Delegate. Accept help. Community is part of God’s design for our well-being. Releasing Control & Trusting God Biblical Insight: Jesus said, “Come to me, all who are weary… and I will give you rest” (Matthew 11:28). Trusting God’s sovereignty brings peace (Isaiah 26:3). Science: Chronic stress stems from feeling out of control. Releasing worries to God reduces anxiety, lowers blood pressure, and improves mental health. Application: Regularly surrender your burdens to God. Journal prayers. Meditate on Scriptures about His faithfulness. By aligning our lives with God’s rhythms and applying scientific wisdom, we can reduce overwhelm and prevent burnout and experience lasting peace. Practical Tips for How to Set Healthy, God-Honoring Boundaries Recognize that “No” is a Complete Sentence You don’t need to over-explain or justify your decision. Jesus simply said “yes” or “no” (Matthew 5:37). When we recognize that saying no is a way to honor God’s best for us, we can do so with confidence. Pray Before You Commit Proverbs 3:5-6 reminds us, “Trust in the Lord with all your heart and lean not on your own understanding; in all your ways submit to him, and he will make your paths straight. ”Before saying yes to anything, take a moment to pray and ask, Is this God’s best for me in this season? Set Priorities Based on God’s Calling Ephesians 2:10 tells us that we are created for good works that God prepared in advance for us. This means that we are not called to do everything—only what He has specifically prepared for us. Identify what God is calling you to do in this season and let that guide your commitments. Understand That Saying No Opens the Door for God’s Yes When we fill our schedules with obligations, we leave no room for the divine appointments God has for us. Saying no creates margin for God’s greater yes. Isaiah 30:21 says, “Whether you turn to the right or to the left, your ears will hear a voice behind you, saying, ‘This is the way; walk in it.’” Practice Saying No with Grace and Love You can say no in a way that honors both God and the other person. Here are a few ways: “Thank you for thinking of me, but I can’t commit to that right now.” “I appreciate the opportunity, but I need to focus on what God has called me to in this season.” “I’d love to help another time, but my plate is full right now.” Encouraging Scripture to Empower You: Learning to say no without feeling guilty Galatians 1:10 – “Am I now trying to win the approval of human beings, or of God? Or am I trying to please people? If I were still trying to please people, I would not be a servant of Christ.” Matthew 11:28-30 – Jesus calls us to rest in Him, not to take on every burden. Psalm 46:10 – “Be still, and know that I am God.” Sometimes, God’s best for us is rest. Ecclesiastes 3:1 – “There is a time for everything, and a season for every activity under the heavens.” We must discern what is right for this season. Colossians 3:23 – “Whatever you do, work at it with all your heart, as working for the Lord, not for human masters.” Our commitments should be done with joy and purpose, not guilt. Scripture References: Luke 5:16 “But Jesus often withdrew to lonely places and prayed.” Galatians 1:10 “Am I now trying to win the approval of human beings, or of God? Or am I trying to please people? If I were still trying to please people, I would not be a servant of Christ.” Matthew 11:28-30 Jesus calls us to rest in Him, not to take on every burden. Psalm 46:10 “Be still, and know that I am God.” Sometimes, God’s best for us is rest. Ecclesiastes 3:1 “There is a time for everything, and a season for every activity under the heavens.” We must discern what is right for this season. Colossians 3:23 “Whatever you do, work at it with all your heart, as working for the Lord, not for human masters.” Our commitments should be done with joy and purpose, not guilt. Saying no is not a rejection of others—it is a way of saying yes to what God has planned for you. You don’t have to live overwhelmed and exhausted. You can move from overcommitted to overjoyed by setting God-honoring boundaries. I encourage you this week to pray over your commitments. Ask God to show you where you need to say no so you can say yes to His best. If today’s episode resonated with you, share it with a friend who needs encouragement in this area. And as always, if you need more hope-filled encouragement, visit my website DrMichelleB.com or connect with me on social media. If you know someone who routinely falls prey to people-pleasing, or is feeling overwhelmed, please consider sharing this episode with them to offer a biblically-based hope-filled perspective. Recommended Resources: Sacred Scars: Resting in God’s Promise That Your Past Is Not Wasted by Dr. Michelle Bengtson The Hem of His Garment: Reaching Out To God When Pain Overwhelms by Dr. Michelle Bengtson, winner AWSA 2024 Golden Scroll Christian Living Book of the Year and the 2024 Christian Literary Awards Reader’s Choice Award in the Christian Living and Non-Fiction categories YouVersion 5-Day Devotional Reaching Out To God When Pain Overwhelms Today is Going to be a Good Day: 90 Promises from God to Start Your Day Off Right by Dr. Michelle Bengtson, AWSA Member of the Year, winner of the AWSA 2023 Inspirational Gift Book of the Year Award, the 2024 Christian Literary Awards Reader’s Choice Award in the Devotional category, the 2023 Christian Literary Awards Reader’s Choice Award in four categories, and the Christian Literary Awards Henri Award for Devotionals YouVersion Devotional, Today is Going to be a Good Day version 1 YouVersion Devotional, Today is Going to be a Good Day version 2 Revive & Thrive Women’s Online Conference Revive & Thrive Summit 2 Trusting God through Cancer Summit 1 Trusting God through Cancer Summit 2 Breaking Anxiety’s Grip: How to Reclaim the Peace God Promises by Dr. Michelle Bengtson, winner of the AWSA 2020 Best Christian Living Book First Place, the first place winner for the Best Christian Living Book, the 2020 Carolina Christian Writer’s Conference Contest winner for nonfiction, and winner of the 2021 Christian Literary Award’s Reader’s Choice Award in all four categories for which it was nominated (Non-Fiction Victorious Living, Christian Living Day By Day, Inspirational Breaking Free and Testimonial Justified by Grace categories.) YouVersion Bible Reading Plan for Breaking Anxiety’s Grip Breaking Anxiety’s Grip Free Study Guide Free PDF Resource: How to Fight Fearful/Anxious Thoughts and Win Hope Prevails: Insights from a Doctor’s Personal Journey Through Depression by Dr. Michelle Bengtson, winner of the Christian Literary Award Henri and Reader’s Choice Award Hope Prevails Bible Study by Dr. Michelle Bengtson, winner of the Christian Literary Award Reader’s Choice Award Free Webinar: Help for When You’re Feeling Blue Social Media Links for Host: For more hope, stay connected with Dr. Bengtson at: Order Book Sacred Scars / Order Book The Hem of His Garment / Order Book Today is Going to be a Good Day / Order Book Breaking Anxiety’s Grip / Order Book Hope Prevails / Website / Blog / Facebook / Twitter (@DrMBengtson) / LinkedIn / Instagram / Pinterest / YouTube / Podcast on Apple Hosted By: Dr. Michelle Bengtson Audio Technical Support: Bryce Bengtson Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.

Many challenging medical conditions defy treatment and challenge clinicians to come up with innovative solutions—Chronic Fatigue Syndrome, fibromyalgia, Lyme Disease, Multiple Chemical Sensitivity (MCS), Ehlers-Danlos Syndrome (EDS) and autoimmune conditions; add now the growing burden of patients with Long Covid and vaccine injury. Dr. Tania Dempsey specializes in treating these complicated chronic disorders. She has embraced and advanced a new paradigm based on addressing Mast Cell Activation Syndrome (MCAS). What is MCAS? How is it differentiated from ordinary allergies, and why are its symptoms so pervasive? What are its causes and triggers? What role for low-histamine diets? Antihistamines? Other novel medications? What nutritional supplements can facilitate its resolution? How does recognition of the contribution of MCAS facilitate treatment of patients suffering from Long Covid and vaccine injuries?

Dr. Hoffman continues his conversation with Dr. Tania Dempsey.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're delving into a series of fascinating updates that underscore a period of significant scientific advancement, strategic partnerships, and regulatory developments in the industry.Starting with Dianthus Therapeutics, which has taken a bold step by investing up to $1 billion to license a bifunctional fusion protein from Nanjing Leads Biolabs. This protein targets autoimmune disorders, a field of immense interest due to the unmet medical needs and potential for breakthrough treatments. Such substantial financial commitments highlight the ongoing trend in the biotech sector towards innovative therapies for autoimmune diseases. In parallel, Sanofi has secured a $500 million agreement with Evoq Therapeutics, continuing its strategic focus on next-generation autoimmune technologies. This partnership aligns with Sanofi's broader strategy to leverage cutting-edge science in managing autoimmune conditions more effectively. Sanofi's engagement with Evoq Therapeutics stands out as a significant step forward in conquering autoimmune diseases through nanodisc technology designed to facilitate the development of curative treatments for disorders like celiac disease and type 1 diabetes. This collaboration reflects a growing trend among pharmaceutical giants investing in advanced biotechnologies that promise transformative impacts on disease management and patient care.Meanwhile, AstraZeneca's renewed collaboration with Immunai, valued at $85 million, seeks to enhance therapies for inflammatory bowel disease through artificial intelligence. This collaboration is part of a wider industry movement towards utilizing AI in drug discovery and development, particularly for complex diseases like IBD. AI's ability to process large datasets and identify potential therapeutic targets faster and more accurately is revolutionizing how companies approach drug development.In clinical trial news, Praxis Precision Medicines has reported positive Phase 3 results for ulixacaltamide in treating essential tremor. This outcome reverses prior concerns from interim analyses and illustrates the persistent innovation in neurological disorder treatments. Similarly, AiCuris has announced successful results from its Phase 3 trial of pritelivir for refractory herpes simplex virus infections in immunocompromised patients. This success paves the way for an FDA filing, demonstrating ongoing progress in antiviral therapy development.Novartis is also making strides with favorable outcomes from its Phase 3 trial of fabhalta for IgA nephropathy. As a complement factor B inhibitor, fabhalta has shown efficacy in slowing kidney function decline, which may lead to a new standard of care for this chronic kidney disease. Novartis plans to file these findings with regulatory bodies soon, highlighting its strategic focus on diversifying into rare kidney diseases.Turning to industry trends, there is significant investment activity in antibody-drug conjugates (ADCs). French biotech company ADCytherix has raised $122 million to advance these targeted therapies into clinical trials. ADCs are gaining traction due to their precision in targeting cancer cells while minimizing damage to healthy tissues. Such advancements signal a potential shift in cancer treatment paradigms toward more targeted and less toxic therapies. Similarly, Tubulis raised an impressive Series C funding round to advance work on ADCs targeting ovarian and lung cancers, underscoring the growing interest in the potential of ADCs engineered to deliver cytotoxic drugs specifically to cancer cells.In another intriguing development, research has shown that a common diabetes drug can alleviate brain inflammation in female mice with multiple sclerosis. This finding exemplifies the growing interest in drug repurposSupport the show

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Let's dive into the latest news shaping this dynamic industry.Bristol Myers Squibb recently made headlines with their acquisition of Orbital Therapeutics for a remarkable $1.5 billion. This strategic move is aimed at enhancing their in vivo cell therapy capabilities, particularly in treating autoimmune disorders. In vivo cell therapy is a pioneering approach that allows genetic modifications directly within a patient's body, potentially revolutionizing the treatment landscape for numerous conditions. This acquisition underscores Bristol Myers Squibb's commitment to pushing the boundaries of innovative cell therapy technologies and reflects a broader trend in the industry towards personalized medicine.In another significant development, AstraZeneca has aligned with the Trump administration's Most Favored Nation pricing program, agreeing to provide Medicaid drugs at prices competitive on a global scale. This decision marks a strategic shift towards cost reduction, especially in chronic disease management and respiratory therapeutics. The move is indicative of AstraZeneca's efforts to adapt to regulatory pressures and evolving policies that emphasize value-based healthcare delivery.Meanwhile, Ypsomed has announced plans to invest $248 million in establishing a manufacturing facility in North Carolina. This facility will focus on producing auto-injectors, essential for treating diabetes and metabolic disorders. The investment signifies a strategic operational expansion aimed at meeting rising demand in North America, highlighting the growing importance of drug delivery devices in the therapeutic landscape.Turning to clinical trials, Regeneron has unveiled promising Phase 1/2 data for its DB-OTO gene therapy targeting genetic hearing loss in children. By using AAV vectors to address DFNB9-related synaptic transmission deficits, this therapy could mark a breakthrough for those suffering from hereditary hearing conditions. Satellos has also presented encouraging Phase 1 results for SAT-3247, an oral small molecule targeting AAK1 in Duchenne muscular dystrophy, with plans to proceed to Phase 2 trials focused on muscle regeneration.In oncology, Taiho and Cullinan's Phase 2 data on zipalertinib showed efficacy against EGFR-mutated non-small cell lung cancer with brain metastases. This advancement highlights the potential of tyrosine kinase inhibitors in precision oncology. Similarly, Arcus Biosciences reported a median survival of 26.7 months for its combination therapy with domvanalimab and zimberelimab in gastroesophageal adenocarcinoma trials, underscoring the promise of TIGIT-targeted therapies.Assembly Biosciences has shared promising Phase 1b results for its ABI-5366 helicase-primase inhibitor, achieving an impressive 94% reduction in herpes simplex virus shedding. OS Therapies reported significant survival improvement with its OST-HER2 vaccine in recurrent pulmonary metastatic osteosarcoma patients, positioning HER2-targeting immunotherapies as promising cancer treatment interventions.Cabaletta Bio has made strides with its resecabtagene autoleucel CAR-T therapy, demonstrating B cell elimination without preconditioning in pemphigus vulgaris trials. This innovation opens new doors for autoimmune disease management through advanced cell therapies.On the business development front, Roche's out-licensing of its GLP-1/GIP agonist CT-388 to Chugai for diabetes and obesity treatment exemplifies strategic partnerships focused on addressing metabolic disorders through novel small molecules.The sector is also witnessing significant financial activities with Evommune filing an IPO to advance treatments for inflammatory conditions. Meanwhile, Quoin Pharmaceuticals raised $104.5 million through private placement to concentrate on rare disSupport the show

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Send us a textDr. Michael McCullar, PhD is Chief Executive Officer  of RegCell ( https://regcellbio.com/ ), a biotechnology company has developed a best-in-class proprietary platform that allows the generation of epigenetically reprogrammed antigen-specific regulatory T-cells (Tregs) that are stable in vivo and maintain a high degree of functionality (S/F-Epigen-Tregs) to restore immune tolerance and ultimately reverse autoimmune disorders as well as the limitations with transplantation.Dr. McCullar has a wealth of experience in the biotech and pharmaceutical industries, spanning more than two decades. Throughout his career, he has been involved in various aspects of drug development and played pivotal roles in the success of several pharmaceutical companies. Dr. McCullar formerly served as the CEO of OnQuality Pharmaceuticals, where he provided executive leadership to this targeted oncology supportive therapy company focused on developing pioneering medications tailored to address the intricacies of cancer treatment-related toxicities. Before that, he was Chief Operating Officer at Tolero Pharmaceuticals, where he had a prominent role in the company's acquisition by Sumitomo Dainippon Pharma and also served as the Senior Vice President of Business Development at Astex Pharmaceuticals, during it's acquisition by Otsuka Pharmaceuticals. Dr. McCullar has held several high-level executive positions at SuperGen, showcasing his commitment and upward career path within the company. His journey at SuperGen culminated in the role of Senior Vice President of Strategy and Operations, where his expertise paved the way for the U.S. Food and Drug Administration (FDA) approval of Dacogen as a treatment for myelodysplastic syndromes, and the acquisition of Astex Therapeutics, which resulted in the formation of Astex Pharmaceuticals, Inc.Dr. McCullar holds a Ph.D. in Toxicology from the University of California, Riverside and an MBA from the W.P. Carey School of Business at Arizona State University.#MichaelMcCullar #RegCell #RegulatoryTCells #Tregs #AutoimmuneDisorders #Transplantation #ShimonSakaguchi #ImmuneSystem #SelfAntigens #Tolerance #AntiInflammatoryCytokines #AntigenPresentingCells #Thymus #BoneMarrow #Anergy #AntigenSpecificTregs #AntigenTargeting #Homing #EpigeneticEditing #Reprogramming #AutologousManufacturing #Japan #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Join Dr. Philip Ovadia for a powerful conversation with Angela Lerro—Intuitive Reiki Master, Carnivore Health Coach, and survivor of breast cancer and neurological Lyme disease. After over a decade of fighting for her life, Angela rebuilt her health and now guides others through complex chronic and autoimmune conditions. She combines animal-based nutrition, trauma-informed coaching, energy work, and nervous system healing to help clients around the world reconnect mind, body, and spirit.Send Dr. Ovadia a Text Message. (If you want a response, you must include your contact information.) Dr. Ovadia cannot respond here. To contact his team, please send an email to team@ifixhearts.com Like what you hear? Head over to IFixHearts.com/book to grab a copy of my book, Stay Off My Operating Table. Ready to go deeper? Talk to someone from my team at IFixHearts.com/talk.Stay Off My Operating Table on X: Dr. Ovadia: @iFixHearts Jack Heald: @JackHeald5 Learn more: Stay Off My Operating Table on Amazon Take Dr. Ovadia's metabolic health quiz: iFixHearts Dr. Ovadia's website: Ovadia Heart Health Jack Heald's website: CultYourBrand.com Theme Song : Rage AgainstWritten & Performed by Logan Gritton & Colin Gailey(c) 2016 Mercury Retro RecordingsAny use of this intellectual property for text and data mining or computational analysis including as training material for artificial intelligence systems is strictly prohibited without express written consent from Dr. Philip Ovadia.

For weight loss, complete avoidance of ultra-processed foods outperforms mere “healthy diet” comprising minimally-processed items; Research fraud undermines anti-dementia drug pipeline; Comprehensive lifestyle modification program scores against cognitive decline; Women's brains especially vulnerable to Omega-3 deficiencies; Bible says “Lame shall walk again” and 21st century science may soon bring about this miracle; Breakthroughs in rheumatoid arthritis treatment.

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim's intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint's RA implant + Kelly Owens's turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what's just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn't)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf's setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what's next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to "PICU Doc on Call," the podcast where real cases meet real expertise at the bedside! Join Dr. Monica Gray, Dr. Pradip Kamat, and Dr. Rahul Damania as they unravel the mysteries of pediatric critical care. In today's episode, our team dives into the compelling case of a previously healthy seven-year-old girl who arrives with seizures, right arm weakness, and sudden respiratory failure. Together, they'll break down the diagnosis and management of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, also known as MOGAD. This autoimmune demyelinating disorder can challenge even the most seasoned clinicians. Tune in as our experts walk you through the clinical features, essential diagnostic workup, and the critical importance of early immunosuppressive therapy. Whether you're at the bedside or on the go, this episode is packed with practical pearls and a multidisciplinary approach to recognizing and treating acute pediatric neuroimmunological emergencies in the PICU. Let's get started!Show Highlights:Presentation of a complex pediatric case involving a seven-year-old girl with new-onset seizures and acute respiratory failureDiscussion of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) as an autoimmune demyelinating disorderOverview of the clinical presentation and diagnostic criteria for autoimmune encephalitisImportance of a broad differential diagnosis, including infectious and autoimmune causes, in pediatric patients with seizures and neurological deficitsDiagnostic approach involving MRI, lumbar puncture, and antibody testing for MOGADManagement strategies for MOGAD, including stabilization, seizure control, and immunosuppressive therapyNeurocritical care considerations for monitoring and treating elevated intracranial pressureLong-term management challenges and the need for multidisciplinary care in pediatric patients with MOGADDiscussion of potential outcomes and the risk of relapse in children with MOGAD.Emphasis on the importance of early and comprehensive diagnostic testing to avoid misdiagnosisReferences:Fuhrman & Zimmerman - Pediatric Critical Care 6th Edition, Chapter 64Gole S, Anand A. Autoimmune Encephalitis. [Updated 2023 Jan 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK578203/Salama S, Khan M, Pardo S, Izbudak I, Levy M. MOG antibody-associated encephalomyelitis/encephalitis. Mult Scler. 2019 Oct;25(11):1427-1433. doi: 10.1177/1352458519837705. Epub 2019 Mar 25. PMID: 30907249; PMCID: PMC6751007Lancaster E. The Diagnosis and Treatment of Autoimmune Encephalitis. J Clin Neurol. 2016 Jan;12(1):1-13. doi: 10.3988/jcn.2016.12.1.1. PMID: 26754777; PMCID: PMC4712273.Fisher KS, Illner A, Kannan V. Pediatric neuroinflammatory diseases in the intensive care unit. Semin Pediatr Neurol. 2024 Apr;49:101118. Doi: 10.1016/j.spen.2024.101118. Epub 2024 Feb 1. PMID: 38677797.Hébert J, Muccilli A, Wennberg RA, Tang-Wai DF. Autoimmune Encephalitis and Autoantibodies: A Review of Clinical Implications. J Appl Lab Med. 2022 Jan 5;7(1):81-98. Doi: 10.1093/jalm/jfab102. PMID: 34996085.Lopez JA, Denkova M, Ramanathan S, Dale RC, Brilot F. Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease. Clin Transl Immunology. 2021 Jul 26;10(7):e1316. doi: 10.1002/cti2.1316. PMID: 34336206; PMCID: PMC8312887.

New therapies for myositis and Sjögren disease: are you up to date? Credit available for this activity expires: 7/15/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002691?ecd=bdc_podcast_libsyn_mscpedu

If you liked this and want to learn more go to my new website www.DrAnthonyChaffee.com   ✅Join my PATREON for early releases, bonus content, and weekly Zoom meetings! https://www.patreon.com/AnthonyChaffeeMD ✅Sign up for our 30-day carnivore challenge and group here! https://www.howtocarnivore.com/ ✅Stockman Steaks, Australia Discount link for home delivered frozen grass-fed and grass finished pasture raised meat locally sourced here in Australia! Use discount code "CHAFFEE" for free gift with qualifying orders! http://www.stockmansteaks.com.au/chaffee ✅ 60-minute consultation with Dr Chaffee https://calendly.com/anthonychaffeemd/60-minute-consultation   Sponsors and Affiliates: ✅ Brand Ambassador for Stone and Spear tallow and soaps referral link https://www.stoneandspeartallow.com/?ref=gx0gql8b Discount Code "CHAFFEE" for 10% off ✅ Carnivore t-shirts from the Plant Free MD  www.plantfreetees.com ✅THE CARNIVORE BAR: Discount Code "Anthony" for 10% off all orders!   https://the-carnivore-bar.myshopify.com/?sca_ref=1743809.v3IrTuyDIi ✅Schwank Grill (Natural Gas or Propane) https://glnk.io/503n/anthonychaffeemd $150 OFF with Discount Code: ANTHONYMD ✅X3 bar system with discount code "DRCHAFFEE" https://www.kqzyfj.com/click-100676052-13511487 ✅Shop Amazon https://www.amazon.com/shop/anthonychaffeemd?ref=ac_inf_hm_vp   And please like and subscribe to my podcast here and Apple/Google podcasts, as well as my YouTube Channel to get updates on all new content, and please consider giving a 5-star rating as it really helps!   This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

In today's episode, Dr. Robert Whitfield and Dr. Micah Pittman, a chiropractor with a background in neuroscience and biochemistry, discuss breast implant illness (BII). Dr. Pittman shares his wife Shiloh's journey, detailing her symptoms like autoimmune issues and joint pain, and her significant health improvements post-explant surgery. They explore the potential causes of BII, including implant degradation and bacterial contamination. Tune in to hear about the importance of holistic health practices, emotional support, and informed decision-making for women considering explant surgery to address BII symptoms. Bio: Dr. Micah Pittman Dr. Micah Pittman has had an exciting career in natural health care. He spent several years in Abu Dhabi/Dubai, training and treating fellow martial artists, as well as elite members of the government. He comes from a family of chiropractors and has practiced in San Diego, Los Angeles, Abu Dhabi, Seattle, and now, is happy to call Lakeway, TX, home. Connect with Dr. Pittman - 620 Chiropractic (https://620chiropractic.com/) Show Highlights: Autoimmune Dysfunction Correlation (00:07:15) Correlation between breast implants and autoimmune disorders in patients Impact of Diet and Implants (00:10:30) Diet's impact on health issues in patients Intra-cavity Pressure Effects (00:11:17) Intra-cavity pressure from implants on nerve roots and overall health Lymphatic Congestion (00:12:19) Lymphatic drainage issues related to breast implants Surgical Observations (00:13:14) Dr. Whitfield shares observations on tissue changes during explant surgeries. Chronic Inflammation and Pathology (00:14:21) Chronic inflammation that is observed in patients post-surgery Bacterial Growth and Leakage (00:14:35) Bacterial contamination related to implant leakage and its health effects Discussion on Implants and Infections (00:38:05) Dr. Whitfield explains the risks of infections and chronic inflammation associated with implants. Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?t=8oQyjO25X5i&r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems.  Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases.  I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]

Rob Armstrong, CEO of Artax Biopharma, highlights the basic mechanism of action of Nck modulators and how they differ from traditional immunosuppressant drugs to treat autoimmune diseases. Taking this adjustable thermostat approach aims to modulate the immune response rather than completely suppressing the response, potentially reducing side effects. The oral, small molecule drug is an advantage over injectable biologics currently dominating the automimmune disease treatment landscape. Rob explains, "Nck stands for non-catalytic kinase, and what Nck is is an adapter protein that interacts with the T cell receptor. Its role is basically to amplify any signals when an antigen is presented to the T cell receptor. It's really interesting because it's called signal one. In other words, it's the beginning of the immune cascade when an antigen is presented. And what's interesting is that it's upstream of what the target of most other drugs are, which are the cytokines that are the offending entities for many of the autoimmune diseases. So what Nck does basically is it amplifies different types of antigens that are bound to the T cell receptor." "So, T cell receptors are a fascinating construct of proteins because they need to address the binding of antigens that are across an incredibly different range of avidity. In other words, it has to be able to be activated by both very strong avidity antigens and weak antigens. So what Nck does is it amplifies the signal when the antigen is a weak antigen, but when it's a strong antigen, Nck is really not necessary at all. And that particular distinction is why we modulate the immune system instead of suppressing it."  #ArtaxPharma #AutoimmuneDiseases #AtopicDermatitis #immunomodulation #NckModulators #TCellActivation #psoriasis #Dermotology artaxbiopharma.com Listen to the podcast here

Rob Armstrong, CEO of Artax Biopharma, highlights the basic mechanism of action of Nck modulators and how they differ from traditional immunosuppressant drugs to treat autoimmune diseases. Taking this adjustable thermostat approach aims to modulate the immune response rather than completely suppressing the response, potentially reducing side effects. The oral, small molecule drug is an advantage over injectable biologics currently dominating the automimmune disease treatment landscape. Rob explains, "Nck stands for non-catalytic kinase, and what Nck is is an adapter protein that interacts with the T cell receptor. Its role is basically to amplify any signals when an antigen is presented to the T cell receptor. It's really interesting because it's called signal one. In other words, it's the beginning of the immune cascade when an antigen is presented. And what's interesting is that it's upstream of what the target of most other drugs are, which are the cytokines that are the offending entities for many of the autoimmune diseases. So what Nck does basically is it amplifies different types of antigens that are bound to the T cell receptor." "So, T cell receptors are a fascinating construct of proteins because they need to address the binding of antigens that are across an incredibly different range of avidity. In other words, it has to be able to be activated by both very strong avidity antigens and weak antigens. So what Nck does is it amplifies the signal when the antigen is a weak antigen, but when it's a strong antigen, Nck is really not necessary at all. And that particular distinction is why we modulate the immune system instead of suppressing it."  #ArtaxPharma #AutoimmuneDiseases #AtopicDermatitis #immunomodulation #NckModulators #TCellActivation #psoriasis #Dermotology artaxbiopharma.com Download the transcript here

Do you wish you knew the best foods to reduce inflammation?  Are you confused trying to find the best diet for autoimmune disorders? Are you desperate for a solution to unhealthy eating habits that are making your autoimmune symptoms unbearable? If this sounds like you, keep listening! In this episode I will break down: The most popular diets for autoimmune disease & their benefits. The key things all these diets are missing to make an anti-inflammatory lifestyle sustainable. What you can do instead to make healthy food choices consistently to reduce inflammation. How to make an anti-inflammatory diet stick to heal your autoimmune symptoms for good. Join my signature program to heal your autoimmune symptoms: The Autoimmune Reboot   Mini Courses: 4-Week Gut Reset Meal Planning with Pinterest   Connect with me: www.ashleycavolo.com Instagram @ashleycavolohealthcoach Facebook Youtube @ashleycavolollc info@ashleycavolo.com   Shop my favorite health & wellness products: Store Shop my favorite health & fitness products Zuma Nutrition  Get 15% off your purchase with this link! The Elderberry Co Boost your immune system with this amazing pure elderberry brand! Thrive Market  Get 30% off your purchase & a $60 FREE gift  

HR2 Dr. Scott Faulkner: Scott Whatley's Stem Cell Story. Autoimmune Disorders. Covid Vax 4-30-25 by John Rush

On the previous two episodes we learned about the dangers of antibiotics and what we can use instead. But what do you do if you've taken antibiotics and your gut is now a mess? On this episode of Vitality Radio, Jared shares exactly how you can rebuild your gut microbiome in the aftermath of antibiotics or other assaults on your system. He dives into the concept of gut dysbiosis and specifically, leaky gut. You'll learn the causes and symptoms, such as food sensitivities, brain fog, mood disturbances and autoimmune disorders. You'll learn the difference between Probiotics, Spores, Postbiotics, and Prebiotics and how these are all important to heal and seal the gut wall, and restore balance and critical diversity in your microbiome.  Products DiscussedAdditional Information:#527: The Dangerous Truth About Antibiotics#528: Natural Alternatives to Antibiotics: How to Support Your Body Through Common Challenges#507: Comprehensive Digestive Support to Get Your Gut ‘Back On Tract'!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Autoimmune Disorders and Skin Rashes: How Skincare Impacts Autoimmune Disorders. Learn about the importance of your skin and skin care for autoimmune disorders, The role of skin rashes and autoimmune disorders and how to deal with them. Dr. Ebru Karpuzoglu is a globally recognized immunologist, molecular medicine scientist, and thought leader in hormonal immunity, inflammation, and longevity. With over 25 years of research, she has made pioneering contributions to understanding how estrogen shapes immune resilience, chronic inflammation, and aging, particularly in women's health. Her groundbreaking discovery on estrogen's role in inflammatory pathways has been widely cited in peer-reviewed scientific journals, influencing the fields of autoimmunity, immune aging, and dermatological science. Passionate about translating cutting-edge research into real-world applications, Dr. Ebru founded AveSeena in 2020—the first skincare brand focused on skin immunity and inflammaging, harnessing the power of advanced molecular science for beauty and wellness. Dr. Ebru's work has been featured in leading industry platforms, including Cosmetic Design and the Skin Anarchy Podcast, where she shares her expertise on the science of inflammation, skin longevity, and immune health. http://aveseena.com  Use code HEALING for a 15% discount. I recommend starting with the sample pack for $25   

In this episode of the School of Doza podcast, we go behind the scenes of autoimmunity to explore what's really triggering your symptoms. From past infections to gut dysfunction, vitamin D deficiency, adrenal overload, and genetics—this episode unpacks the root causes that conventional medicine often overlooks. 5 KEY TAKEAWAYS Most autoimmune disorders are connected to previous infections, including viruses and bacteria. A damaged gut barrier can trigger immune dysregulation—leaky gut is real. Vitamin D isn't optional: low levels suppress the immune system's ability to respond. Chronic stress and overactive adrenals can drive autoimmune flare-ups. Genetic variants like MTHFR may increase susceptibility to autoimmune conditions. FEATURED PRODUCT The Good Poops Challenge is an 8-week reset designed to support your gut, liver, and gallbladder—key systems often disrupted in autoimmune conditions. As discussed in this episode, improving digestion is foundational for reducing inflammation and supporting immune resilience. Join the Good Poops Challenge → TIMESTAMPS 00:00 START 01:25 — What autoimmune conditions have in common 04:30 — Infections as a root cause: viral, bacterial, and parasitic 09:40 — PANDAS and strep-related autoimmune patterns 13:15 — How childhood antibiotics disrupt the microbiome 15:22 — The gut barrier: your body's frontline defense 19:10 — Why fast food (like Chick-fil-A) wrecks your gut 24:33 — Leaky gut and its link to chronic inflammation 27:48 — The liver's overlooked role in storing toxicity 31:10 — Why Good Poops supports your gut–liver–gallbladder axis 33:42 — Vitamin D deficiency and its role in immune regulation 38:50 — How to interpret your vitamin D labs 42:05 — Adrenal overactivation and chronic cortisol 45:15 — Flight-or-fight mode and immune suppression 48:20 — The hidden genetic component: MTHFR and autoimmune risk RESOURCES MENTIONED “How Infections May Trigger Autoimmune Disease” – https://www.ncbi.nlm.nih.gov/books/NBK459437/ “Autoimmune and Inflammatory Mechanisms” – https://pmc.ncbi.nlm.nih.gov/articles/PMC10920276/ “Autoimmunity, Microbiota, and Gut Barrier” – https://pubmed.ncbi.nlm.nih.gov/28919485/ “Vitamin D and Autoimmune Disease” – https://pmc.ncbi.nlm.nih.gov/articles/PMC9010814/ “Stress, Cortisol, and Immunity” – https://pmc.ncbi.nlm.nih.gov/articles/PMC9207529/ “MTHFR Gene and Autoimmune Disorders” – https://pmc.ncbi.nlm.nih.gov/articles/PMC4499570/

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman welcome Dr. Aimee Pugh Bernard to explore the intricate world of autoimmunity. The scientists examine the fundamental nature of autoimmune disorders, explaining how these conditions develop when the immune system mistakenly attacks healthy tissues. They discuss the challenges in diagnosing these diverse conditions, the critical interplay between genetic predisposition and environmental triggers, and focus on specific examples like celiac disease. The conversation addresses common misconceptions surrounding autoimmune conditions and emphasizes evidence-based approaches to management, while clarifying important questions about the relationship between vaccinations and autoimmune diseases. (00:00) Intro (02:35) Understanding Autoimmunity (08:51) Types of Autoimmune Disorders (11:34) Diagnosis and Testing for Autoimmunity (19:21) Causes and Risk Factors of Autoimmunity (24:25) The Role of Genetics and Environment (25:30) Celiac Disease and Its Unique Aspects (27:23) The Dangers of Misinformation in Autoimmunity (33:23) Understanding Autoimmune Disease Management (40:18) Debunking Myths About Autoimmunity (44:19) Vaccination and Autoimmunity: Facts vs. Fiction https://nationalhealthcouncil.org/blog/a-major-health-crisis-the-alarming-rise-of-autoimmune-disease https://theconversation.com/immune-health-is-all-about-balance-an-immunologist-explains-why-both-too-strong-and-too-weak-an-immune-response-can-lead-to-illness-215217 ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.The pharmaceutical industry, traditionally seen as recession-resistant, may face challenges due to Trump's tariffs and the dominance of GLP-1s. Lexeo is moving forward with a gene therapy for Friedreich's ataxia after promising phase I/II data, while Rallybio is pivoting to a new antibody for rare autoimmune disorders. HHS Secretary Robert F. Kennedy, Jr. will not be speaking to the Senate health committee this week as scheduled. In other news, Merida is entering the autoimmune and allergy arena with a $121 million series A funding. Lilly is suing an Indianapolis spa for selling knockoff versions of its migraine drug Zepbound, and biotech shares are affected by the departure of FDA's Marks. Cardiovascular disease is back in the spotlight.

Send us a textHere's the truth: 1 in 3 women will develop an autoimmune condition after giving birth, and hardly anyone in modern medicine is talking about it.What if the “normal” symptoms of postpartum—fatigue, hair loss, mood swings, brain fog—are actually the earliest signs of autoimmune disease and red flags that your client's body is waving, begging for help? Today we're busting the myths around postpartum recovery and diving into the root causes of autoimmune disorders in new mothers. If you're a provider still telling clients “this is just postpartum,” it's time for a reality check. We talk about nutrient depletion, leaky gut, inflammation, unresolved trauma, and why functional postpartum care is the only path forward if we want to stop the rise of chronic illness in mothers. If you're still telling clients “this is just postpartum,” it's time to listen in—because this conversation will change how you practice.Click HERE to check out this episode on the blog. Key Time Stamps: 00:00 – Introduction to the silent postpartum autoimmune crisis 01:00 – Normalized symptoms vs. early signs of disease 04:20 – What's normal postpartum and what's not 06:18 – Miranda's personal experience with ulcerative colitis 09:21 – Root causes of postpartum autoimmune disorders 10:34 – Nutrient depletion and immune dysregulation 11:38 – Trauma, nervous system imbalance, and gut health 13:50 – Environmental toxins and stress 15:39 – Genetic myths and epigenetics 16:30 – Reversing autoimmune disease: What's possible? 18:12 – Why most providers miss the signs 20:12 – Why this matters for the future of postpartum care 21:03 – Get on the Postpartum Provider Press NewsletterNEXT STEPS:

About Rhiannon Neuharth: Rhiannon is a Certified Functional Nutrition Counselor, Board Certified Health Coach with the American Association of Natural Wellness Coaches and a Board-Certified member of the American Association of Drugless Practitioners. She began her journey in functional nutrition after struggling to maintain her chronically ill child's health with antibiotics. Exhausted and overwhelmed, she delved into research, eventually finding her passion in supporting others on the path to optimal health and wellness. With a focus on individuals with MTHFR, Rhiannon provides simple solutions to optimized wellness in just 90 days, without spending endless hours on Google.   What We Discuss In This Episode: Rhiannon shares how her youngest child's autoimmune deficiency and chronic illness led her to discover MTHFR, a genetic variation that affects the body's ability to process folate and other key nutrients. This sparked her passion for functional nutrition and supporting others with MTHFR-related health challenges. What is MTHFR and how does it impact our health? MTHFR stands for methylene tetrahydrofolate reductase, a gene that plays a crucial role in converting folate and homocysteine. Rhiannon explains how MTHFR variations can contribute to a wide range of issues like hormone imbalances, weight problems, fatigue, ADHD, autism, and autoimmune conditions - regardless of age. Strategies for managing MTHFR and supporting overall health Rhiannon discusses the role of diet, lifestyle, stress management, and nervous system regulation in supporting those with MTHFR. She highlights the importance of gut health, hormone balance, and addressing nutrient deficiencies through targeted supplementation. The importance of comprehensive testing  Rhiannon emphasizes the need for comprehensive genetic testing that looks at 165 genes, rather than just one or two. This provides a clear action plan and insights into the root causes of a person's symptoms. She contrasts this with typical doctor-testing that may miss key factors.   Resources from Rhiannon Neuharth: Learn more about comprehensive testing by texting TEST to (321) 335-2414   Connect With Rhiannon Neuharth: Website: https://www.Revitalizing-Wellness.com TikTok: https://www.tiktok.com@MTHFR_Coach Instagram: https://www.instagram.com/Mthfr_Coach   Connect with Lynne: If you're looking for a community of like-minded women on a journey - just like you are - to improved health and wellness, overall balance, and increased confidence, check out Lynne's private community in The Energized Healthy Women's Club. It's a supportive and collaborative community where the women in this group share tips and solutions for a healthy and holistic lifestyle. (Discussions include things like weight management, eliminating belly bloat, balancing hormones, wrangling sugar gremlins,  overcoming fatigue, recipes, strategies, perimenopause & menopause, and much more ... so women can feel energized, healthy, and lighter, with a new sense of purpose. Website:  https://holistic-healthandwellness.com Facebook: https://www.facebook.com/holistichealthandwellnessllc The Energized Healthy Women's Club:  https://www.facebook.com/groups/energized.healthy.women Instagram: https://www.instagram.com/lynnewadsworth LinkedIn:  https://www.linkedin.com/in/lynnewadsworth   Free Resources from Lynne Wadsworth: ✨ Ready to Thrive in Midlife? Let's Make It Happen!

Send us a textEpisode Summary:In this episode of Midlife with Courage, Kim welcomes Emily Black, founder of a menopause-focused gummy supplement business. Emily shares her personal journey of being diagnosed with an autoimmune disorder, navigating perimenopause symptoms, and discovering alternative solutions for relief. She discusses the challenges of receiving proper medical support, the role of cannabis in symptom management, and how she developed her business to help other women.Key Topics:Emily's courageous decision to leave an 18-year marriageHer struggle with an autoimmune disorder (Sjogren's Syndrome) and menopause symptomsHow traditional medicine often dismisses women's health concernsThe benefits of cannabis (THC & CBD) for menopause symptoms like sleep and anxietyThe process of formulating and launching her gummy supplement businessConnect with Emily Black:WEBSITE-Still For Her***Midlife with Courage listeners will get a 20% discount on their first order by using the code "Courage"***DISCLAIMER-the information contained in this episode should not be considered medical advice. Always consult with your healthcare provider before taking any supplements. Get your free ebook called Daily Habits for Hormonal Harmony by going to my website. This free guide will help you balance your hormones through some easy daily activities. Just add your email to the popup and your guide will be on its way to your inbox.From morning until bedtime, you can help yourself feel better! Support the showKim Benoy is a retired RN, Certified Aromatherapist, wife and mom who is passionate about inspiring and encouraging women over 40. She wants you to see your own beauty, value and worth through sharing stories of other women just like you.Would you like to get a "sneak" listen to each podcast? Subscribe to my website to get my weekly inspirational message and a link to that week's podcast a day ahead of everyone else! Just click the link below to get on the list! SUBSCRIBE WEBSITEFACEBOOK

Healthcare Reform: How Christian Elliot is Transforming Healthcare for Autoimmune Disorders. Healthcare reform is badly needed for everyone but it's even more important for people with autoimmune disorders. Learn how Christian Elliot and his company Health United is reforming and transforming healthcare for people with autoimmune disorders. Christian Elliot is a husband and father of six, homeschooled kids. He has been full-time in the “alternative” health space since 2005, logging about 20,000 hours of 1-1 coaching—fitness, nutrition, life, and relationship coaching. He also has a Master of Divinity from Fuller Seminary. Christian is a co-owner of a newly established organization called Healing United—a Private Membership Association that is a collaboration between doctors and coaches working to demonstrate a new healthcare model. Christian doesn't pull any punches calling out the medical system. His main focus is on creating holistic and personalized detox programs to help people overcome a myriad of otherwise "incurable" diseases. He hosts a podcast called Deconstructing Conventional. Check out the website for this podcast at http://autoimmunerehab.com Follow me on instagram at http://instagram.com/annalaurabrownwellness  

Lori Fish Bard is a licensed clinical nutritionist and board certified integrative health coach, and long-time client of Oasis. After finally becoming comfortable with her curls, Lori found her hair thinning after childbirth, and discovered she had an autoimmune disorder called Hashimoto's thyroiditis. She began a journey of learning about the integrated effects on the body of hormones, diet, gut health, and more. Now, as a nutritional counselor, Lori takes a holistic functional approach, looking at digestive and gut health, metabolic syndrome, thyroid health, autoimmunity, celiac disease/gluten sensitivity, and food allergies or sensitivities to help people develop sustainable habits and live a healthy, nourished, balanced life. She played a significant role in helping Wafaya and the team at Oasis learn how to better their own health, including some tricks that benefit hair and scalp health as well. Learn all about those and some other simple things to help improve your health from head to toe!In this episode:Postpartum hair loss is a fairly common, but temporary, phenomenon resulting from hormonal changes during and after pregnancy.A study on black seed oil's effect on thyroid in rats. Essential oil aromatherapy reducing fatigue in women with hypothyroidism. More on the microbiome and immune system.GI-MAP (Gastrointestinal Microbial Assay Plus) testing is a relatively new technology, and while manufacturer Diagnostic Solutions defends the results, independent testing has shown low reliability and high false positives. If you are experiencing gastrointestinal issues you should consult your physician about options.  Studies have linked sugar to inflammation and metabolic disorders, and shown addictive qualities which may indeed trigger a higher reward response than cocaine in test animals.Studies have linked pesticides to gut microbiome changes and secondary effects on hosts.The Environmental Working Group provides the Dirty Dozen and Clean Fifteen lists based on up-to-date USDA data. While the link of specific foods to inflammation is often debated, certain diets have been linked to anti-inflammatory results. Hosted by Ausha. See ausha.co/privacy-policy for more information.

Are you struggling with autoimmune symptoms that doctors keep dismissing? Are you tired of trying endless medications without seeing real improvement? I bring on Heather Gray to share her remarkable journey, from battling multiple chronic conditions for 30 years chronic illnesses including Lyme, Celiac, Hashimoto's, and endometriosis, to becoming a leading voice in natural healing. As a Functional Diagnostic Nutrition practitioner and head coach at a prominent cancer treatment center, Heather breaks down the strategies that finally helped her overcome chronic illness – and now helps others do the same.Today, you'll learn all about:02:06 - Why focusing solely on treatment fails08:01 - Understanding the "perfect host" concept17:15 - The real deal about comprehensive health assessments20:15 - Moving beyond supplements to true healing24:22 - The game-changing power of stress management32:01 - Being your own health advocate37:04 - OutroEpisode resources:Website: renegadehealthboss.comPodcast: Renegade Health BossFacebook: facebook.com/RHBPOD Instagram: @renegade_health_bossYoutube: @RenegadeHealthBoss Support the show

In this episode, we're in deep conversation with Dr. Jill Carnahan, a functional medicine expert and survivor of breast cancer, Crohn's disease, and mold toxicity. Dr. Jill shares her journey through personal and professional transformation, blending medical science with spirituality and self-trust. From navigating health crises to writing her memoir Unexpected, Dr. Jill demonstrates the profound impact of belief, action, and patience in creating healing and resilience. Key Takeaways How Dr. Jill overcame aggressive breast cancer at 25. Practical tips for creating a healthier home with "clean air, clean water, and clean food.” How autoimmune diseases, gut health, and environmental toxins like mold are interconnected. Dr. Jill's three-step process - belief, action, and patience - for navigating life's toughest challenges and fostering resilience. Why storytelling is essential for healing and transformation. Dr. Jill Carnahan: Website: jillcarnahan.com Instagram: @drjillcarnahan YouTube: @JillCarnahanMD Podcast: Resiliency Radio Film: doctorpatientmovie.com Her book: Unexpected DayLuna:   DayLuna Retreat info: daylunalife.com/egypt   EXPLORE LUNYA Use code: DAYLUNA for 15% off   Human Design Chart Software: BodygraphChart.com Use code: DAYLUNA for 50% off your first 12 months!   Book a Reading With Us Here! Get our book: Your Human Design! Your Human Design Besties Online Human Design Reader Training Physical Products & Ritual Kits Digital Products & Video Courses daylunalife.com Instagram: @d.a.y.l.u.n.a

Explore our Gut Powder at mswnutrition.com. It's made with one simple, effective ingredient: L-glutamine, designed to support your gut health without any added fillers or artificial ingredients. Use code “nursedoza” for a special discount.   5 Key Takeaways •Misleading Labels: ‘Natural flavors' often aren't natural at all, comprising complex processes and synthetic chemicals. •Regulatory Gaps: The lack of stringent regulations allows for the widespread use of ambiguous ingredients under the guise of “natural.” •Consumer Misdirection: Marketing strategies effectively use ‘natural flavors' to make products more appealing and addictive. •Health Implications: Consistent consumption of foods with ‘natural flavors' could lead to serious health issues, including neurological disorders from additives like MSG. •Empowered Choices: Educating yourself about ingredients and making informed food choices can drastically improve your health and wellness.   Timestamps •[00:00:30] - Introduction to the topic of natural flavors •[00:02:15] - Breakdown of what ‘natural flavors' really mean •[00:10:45] - Discussion on the lack of regulation and its implications •[00:22:30] - How natural flavors manipulate consumer behavior •[00:35:00] - Strategies for making healthier food choices •[00:48:15] - Closing thoughts and episode wrap-up   Resources Mentioned •FDA Food Additive Amendment (1958): Overview of regulations affecting food labeling •Yooka App: Helps scan and identify risky ingredients in everyday products  

In today's episode with Dr. Terry Wahls, you'll hear us take a deep dive on: 1. The Wahls Protocol 2. Transforming MS 3. Nutrients that help your mitochondria function 4. Early indicators of chronic illnesse Dr. Terry Wahls is a Clinical Professor of Medicine at the University of Iowa Carver College of Medicine and the visionary behind The Wahls Foundation. Despite facing the challenges of secondary progressive multiple sclerosis, she triumphed over her condition by implementing a personalized diet and lifestyle program designed specifically for her brain. Dr. Terry Wahls has not only revolutionized her health journey but has also empowered others through her written works. She authored the influential books, "The Wahls Protocol: How I Beat Progressive MS Using Paleo Principles and Functional Medicine", "The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles", and the invaluable cookbook "The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions".

I don't know about you, but this time of year has me feeling stressed, overwhelmed, and definitely TIRED. I'm often asked about navigating fatigue on your fitness journey. I'm feeling pretty damn fatigued myself right now, so I thought it was fitting to dive into this topic for today's episode!For some reason, we beat ourselves up when we feel so tired, and we think something is *wrong* with us if we don't feel great every.single.day. As human beings, we have SO much happening both within our bodies + in the world around us. Regardless of the season of life you're in, there's no way you're going to feel amazing 24/7.As women, our menstrual cycle impacts our energy levels and overall well-being waaay more than we probably realize. I'm sharing more about the various phases of our cycle + other hormonal conditions (i.e. PCOS, endometriosis) and autoimmune conditions that can lead to energy levels fluctuating, and yes..leave us feeling fatigued.My biggest takeaway I want you to have is to really understand YOUR body - start paying attention to what YOU need. What makes you feel good, and what makes you feel depleted? While you can only control so much, you are in control of educating yourself on your health and well-being.I hope this episode sheds some light on the topic of fatigue and other health challenges + brings more awareness to how important it is to REALLY know your body! In this episode, we cover:Understanding that you WILL get tired, and you won't feel great every single day + not beating yourself up over thisHow the menstrual cycle impacts women + a breakdown of what this looks like during a 30 day time frameCertain hormonal conditions that affect women + how this impacts energy levels throughout your cycleThe physical + emotional toll that autoimmune diseases can take on the bodyWhy it's crucial that you learn your particular body and what YOU needLinks/Resources:Join FIT CLUB, my monthly membership with workouts you can do at home or the gymPRIVATE COACHING is my 1:1 program (choose 3 or 6 month option)Connect with me on Instagram @kristycastillofit and @unfuckyourfitnesspodcast so we can keep this conversation going-be sure to tag me in your posts and stories!Join my FREE Facebook group, Unf*ck Your FitnessClick HERE for my favorite fitness & life things!

Dr. Hoffman continues his conversation with Jim LaValle, co-author of "Peptide Handbook: A Professional's Guide to Peptide Therapeutics."

Jim LaValle, an internationally recognized clinical pharmacist, author, and lecturer, details the emerging field of peptide therapeutics. He discusses the basics of peptides, their roles in various bodily functions, and their therapeutic potentials, including weight loss, immune support, and injury recovery. Jim also shares insights on individualized dosage for GLP-1 drugs, regulatory challenges, the future of peptides in medicine, and exercise tips for seniors. Additionally, Dr. Hoffman explores Jim's role in spearheading the MIORA Longevity Program at Lifetime Gyms, aiming to make gyms not just places for workouts but comprehensive wellness centers focused on longevity and health optimization.

Trauma causes physiological changes to the nervous system. Over time, these impacts may place someone on a trajectory from health to a pre-disease state to a disease state, leading to autoimmunity or autoimmune disorders. Dr. Sara (Gottfried) Szal and Mike Haney discuss Szal's new book “The Autoimmune Cure,” trauma and how it can contribute to autoimmunity, how personalized precision medicine may help individuals reverse autoimmunity and return to a state of health, and how psychedelic therapies can help with addressing trauma. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.