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Monopolies! They're a problem as old as our country itself. On this week's TLDR, we talk to Denise Hearn and Vass Bednar, authors of The Big Fix: How Companies Capture Markets and Harm Canadians, about how Canadian companies got so big. And, we look at a surprising proposal for tackling the problem (at least in the airline industry). Plus, we explore how a new wonder drug could spell the end of the opioid epidemic. And, we watch as the pump and dump gets a makeover for the digital age.This episode was hosted by Devin Friedman, business reporter Sarah Rieger and former hedgefunder Matthew Karasz, with appearances by writers Vass Bednar and Denise Hearn. Follow us on other platforms, or subscribe to our weekly newsletter: linkin.bio/tldrThe TLDR Podcast is offered by Wealthsimple Media Inc. and is for informational purposes only. The content in the TLDR Podcast is not investment advice, a recommendation to buy or sell assets or securities, and does not represent the views of Wealthsimple Financial Corp or any of its other subsidiaries or affiliates. Wealthsimple Media Inc. does not endorse any third-party views referenced in this content. More information at wealthsimple.com/tldr.
"Oh, the people you'll meet, and the places you'll go..."That classic Dr. Seuss line couldn't have been more true when I found myself at a rare disease conference, taking with Dr. Gabriel Cohn. A quiet presence with a resume that reads like a roadmap through the last 30 years of rare disease breakthroughs, Dr. Cohn is the kind of person who reminds you just how much heart and science it takes to change lives.Dr. Gabe Cohn is the Executive Director and Medical Director of the Rosenau Family Research Foundation. He stepped into the role in October, bringing with him over three decades of experience that spans academic medicine and the biotechnology industry. A licensed, board-certified Clinical Geneticist and Obstetrician-Gynecologist, Dr. Cohn has contributed to the development of multiple therapeutics aimed at treating rare genetic disorders—a career built on both clinical precision and compassionate innovation.Beyond RFRF, he's also the Chief Medical Officer at iECURE, Inc., a biotech company pioneering gene editing therapies for rare diseases. His prior leadership roles at Homology Medicines, AVROBIO, OvaScience, and Shire reflect a steady focus on advancing gene therapy and editing platforms. Since 2017 alone, he's played a pivotal role in getting five different cell and gene therapy programs past the critical regulatory gatekeeping stages of IND and CTA submissions.Dr. Cohn isn't just a scientist—he's a builder, a connector, and a relentless advocate for the potential of genetic medicine to rewrite the future for patients with rare diseases.If you would like to get a hold of the Rosenau Foundation: https://rosenaufoundation.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction to The Roll Up TV and Guests01:13 Recent Market Developments and Token Collapses03:39 Bybit's Hybrid DEX Announcement06:05 ETF Filings and Staking Language09:00 Trump and Tron Going Public11:50 Introduction to Himanshu and Sentient12:35 The Vision Behind Sentient and Decentralized AI18:20 The Importance of Verification in AI24:29 Challenges in AI and Crypto Integration28:20 Innovative Projects within the Sentient Ecosystem33:05 DC Builder and Zero Knowledge Machine Learning40:56 Proof of Personhood and the Future of Identity44:33 Decentralized Identity and ZK Technologies50:02 AI in Crypto: Current Landscape and Innovations54:42 The Future of Identity Platforms and User Privacy01:00:08 Blockchain Bottlenecks: Execution vs. Consensus01:05:45 Institutional Interest Beyond Ethereum01:08:32 The Dynamics of On-Chain Speculation01:12:14 The Role of Wallets in User Retention01:18:52 The Future of Stablecoins and AI Integration01:28:51 The Future of Payments: Stablecoins vs. Real-Time Payment Networks01:35:33 The Role of FinTech in Crypto Payments01:36:30 Understanding the Value of Tokens in Crypto01:49:03 JP Morgan's Entry into Stablecoins01:52:20 Building a Brand: Azuki and the Anime Industry
187 - Mason Marangella (Vertex Effects) In episode 187 of “Have Guitar Will Travel”, presented by Vintage Guitar Magazine, host James Patrick Regan speaks with guitarist and owner and founder of Vertex Effects Mason Marangella. Tom Bukovac calls him “Sweet Mason”. In their conversation Mason tells us about his studio where he has a wealth of classic amplifiers, pedals, pedalboards and a crazy guitar collection with one of just about every type of guitar you would want and Mason tells us about where he gets stuff repaired when it's beyond what he can repair himself. Mason discusses his company Vertex Effects and what he does: buffers, boosts pedalboards all used by the top session guitarists as well as performing guitarists. Mason also talks about his YouTube channel and podcast “Chairmen of the Board” where Mason and his contemporaries discuss pedals, pedalboards and their components. Mason tells us how he initially got his pedals in to the hands of the top Nashville players and how he started in the field of pedals in the first place. Mason explains what a “buffer” does and the optimum pedal signal chain. Mason talks about a project he documented on YouTube having a Gibson R9 Les Paul transformed into a 1959 Gibson Les Paul the way 1956 Goldtop Les Pauls are transformed into the 1958 features and what the results were. Finally Mason takes us through what he's looking at for the future. . To find out more about Mason and Vertex Effects you can go to his website vertexeffects.com or the Vertex YouTube channel. Or check out “Chairmen of the Boards” wherever you listen to podcasts. . Please subscribe, like, comment, share and review this podcast! . #VintageGuitarMagazine #MasonMarangella #VertexEffects #BoutiquePedals #PedalBoards #FuzzBox #theDeadlies #BufferPedal #ChairmenoftheBoards #TomBukovac #haveguitarwilltravelpodcast #HGWT Please like, comment, and share this podcast! Download Link
Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma e Biotech world.The CDC has reinstated around 460 employees who were previously fired, with the rehired staff working on viral disease prevention efforts and sexual health testing labs. This comes amid protests and shake-ups at the agency, including the overhaul of the vaccine advisory committee. Experts are concerned about newly appointed members, some of whom are known anti-vaxxers, potentially relitigating recommendations. Sen. Bill Cassidy is being urged to step up in response to these concerns.In other news, NuVation has received FDA approval for its oral lung cancer drug, Biontech has acquired CureVac in a $1.25 billion all-stock deal, and RFK Jr. has named new CDC vaccine advisors following a "clean sweep." Additionally, InVitro Cell Research is focused on discovering interventions to slow aging and prevent age-related diseases and is hiring scientists. The newsletter also includes information on layoffs at Genentech and Vertex.RFK Jr. has named eight new members to the CDC vaccine committee, replacing the 17 members he removed earlier in the week. The new choices seem to align with Kennedy's anti-vaccine views, causing concern among analysts. The HHS secretary's decision to appoint these scientists has raised questions about the committee's future direction.
Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.The American Medical Association is calling for a Senate probe into RFK Jr. after he removed all 17 members of the CDC's vaccine advisory board. They are also urging an immediate reversal of the HHS Secretary's decision. In other news, FDA leaders promise support for gene therapy as it faces challenges, Novo Nordisk invests over $800 million in discovering oral obesity drugs, and a new company, InVitro Cell Research, focuses on interventions to slow aging and prevent age-related diseases. FDA Commissioner Marty Makary and CBER Director Vinay Prasad published an article outlining the FDA's priorities, including accelerating cures and deploying artificial intelligence quickly. Other news includes Lilly's muscle-preserving treatment pact, Vertex laying off staff after axing a diabetes asset, and Genentech reshuffling in South San Francisco. Recursion cuts workforce by 20%.FDA leaders have pledged support to gene therapy makers as the industry faces challenges in commercialization. Despite huge valuations, gene therapies are struggling to reach the market. Poor communication about the value of groundbreaking treatments is hindering their prospects. Right of first negotiation deals do not always lead to mergers and acquisitions, as found by Jefferies in their analysis of licensing deals. Trilink's new comprehensive IVT kit simplifies the production of mRNAs. In other news, Lilly strikes a $650 million deal for a muscle-preserving treatment, Odyssey ends its quest for Nasdaq, BMS expands its radiopharma presence, and SpliceBio secures $135 million in funding for protein splicing medicines. Novo ups its obesity efforts with an $800 million pact, while Cullinan makes a $700 million deal for autoimmune T cell engager in China.Thank you for listening to Pharma and Biotech Daily.
The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction to the Roll Up TV and Guests02:10 Regulatory Developments in DeFi09:17 Hot Takes on Crypto Networks and Moats13:41 Insights from Dimitri on VC Landscape18:00 Quantum Computing and Its Impact on Bitcoin24:30 The Rise of Decentralized Physical Infrastructure Networks30:14 Future of AI and Decentralized Compute36:08 Discussion with DeFi Dad on Ethereum and DeFi Market43:13 Ethereum's Resilience and User Perspective45:41 Innovations in DeFi and New Financial Primitives53:11 The Future of Airdrops and Marketing Strategies01:05:43 Leadership Transition and the ZK Market01:10:05 The Rise of ZK Technology and Its Implications01:19:34 Privacy in ZK Applications and Future Use Cases01:28:25 Real-Time Proving and Performance Milestones01:30:17 The Role of Zero-Knowledge Proofs in Crypto01:31:46 Understanding Chaos Labs and Oracle Problems01:39:21 Resilience in DeFi Protocols01:42:40 The Rise of Central Limit Order Books01:48:45 Solana ETFs and Institutional Interest in Crypto01:51:05 The Evolution of Crypto Media and DeFi Coverage02:04:12 Ethereum Foundation's Shift Towards DeFi
In this episode, we sit down with Joshua Vanderplate, CEO of Vertex Mechanical, a trusted name in heating, cooling, electrical, and plumbing services for over 40 years. Serving Lancaster, Berks, and Lebanon counties, Vertex Mechanical has built a reputation for quality craftsmanship, community-focused service, and their enduring motto: Here For Your Comfort™. Joshua shares the company's journey, insights on leading in the trades industry, and what it takes to maintain trust and excellence across decades of service. Whether you're a homeowner, aspiring entrepreneur, or simply curious about what goes into running a successful service business, this episode offers valuable takeaways.
The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction to DeFi and Recent Headlines02:12 SEC Talks and Market Structure Bill05:09 Regulatory Clarity and Its Implications06:09 Demand for New Tokens and ICOs08:26 Convergence of Markets and Media11:24 Introduction of Rune and Maker's Evolution19:02 Circle's IPO and Its Impact on the Industry21:25 Sky's Business Model and User Base24:37 Targeting Mercenary Capital in DeFi27:27 Sky Agent Framework and Its Functionality33:30 DeFi Interoperability and Notable Projects35:53 Navigating the Risk Framework for Profit Generation38:09 The Exponential Bet on Star Ecosystems40:01 The Future of Stablecoins and AI in Finance41:49 The Resurgence of DeFi and Institutional Interest45:32 Innovative On-Chain Applications and Yield Opportunities49:23 The Role of Ethereum Foundation in DeFi52:12 Building an Incubator for Ethereum Startups54:33 The State of Interoperability in Blockchain01:01:03 Evaluating the Future of Layer 1s and Applications01:12:56 The Stablecoin Boom and Investment Opportunities01:17:21 IPO Trends in Crypto and On-Chain IPOs01:21:11 The Rise of New Founders in Crypto01:26:08 Vibes and Financialization: The Degenification of Society01:41:32 User Experience in Crypto Apps and Wallets
Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain – they’re investigating potential non-opioid based treatment options that aim to target pain differently. This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.See omnystudio.com/listener for privacy information.
The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Trump's Crypto Wallet Launch03:08 The Death of the Crypto Foundation Model06:09 Ethereum's New Model and Strategic Goals09:03 The Future of Ethereum and Its Competition11:49 Delphi's AI Month and Investment Strategies18:05 Building on Athena: The Ethereal Project42:10 The Evolving Landscape of On-Chain Trading43:08 Innovative Features and User Engagement45:58 Building a Vertically Integrated DeFi Ecosystem49:23 Liquidity Challenges and Strategies52:20 User Base and Market Positioning56:08 Iterative Product Development and Success01:00:52 Balancing Adoption and Revenue Generation01:06:31 Institutional Relationships and Tokenization01:10:50 Future of Stablecoins and Market Trends01:25:15 The Rise of Hyper Liquid Trading01:27:11 Shifting Perspectives on Crypto Foundations01:28:36 The Future of Tokenomics and Revenue Generation01:34:39 Founders' Evolving Approach to Business Models01:38:06 New Hampshire: A Hidden Crypto Hub?01:40:34 The Importance of Revenue in Crypto Projects01:43:25 Comparing Ethereum and Solana Events01:45:23 The Lore of Lawrence and Wildcat's Unique Marketing01:51:50 Innovations in Under-Collateralized Lending01:56:58 The Future of Liquidation Mechanisms in DeFi
The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Trump's Crypto Wallet Launch03:08 The Death of the Crypto Foundation Model06:09 Ethereum's New Model and Strategic Goals09:03 The Future of Ethereum and Its Competition11:49 Delphi's AI Month and Investment Strategies18:05 Building on Athena: The Ethereal Project42:10 The Evolving Landscape of On-Chain Trading43:08 Innovative Features and User Engagement45:58 Building a Vertically Integrated DeFi Ecosystem49:23 Liquidity Challenges and Strategies52:20 User Base and Market Positioning56:08 Iterative Product Development and Success01:00:52 Balancing Adoption and Revenue Generation01:06:31 Institutional Relationships and Tokenization01:10:50 Future of Stablecoins and Market Trends01:25:15 The Rise of Hyper Liquid Trading01:27:11 Shifting Perspectives on Crypto Foundations01:28:36 The Future of Tokenomics and Revenue Generation01:34:39 Founders' Evolving Approach to Business Models01:38:06 New Hampshire: A Hidden Crypto Hub?01:40:34 The Importance of Revenue in Crypto Projects01:43:25 Comparing Ethereum and Solana Events01:45:23 The Lore of Lawrence and Wildcat's Unique Marketing01:51:50 Innovations in Under-Collateralized Lending01:56:58 The Future of Liquidation Mechanisms in DeFi
From Costco to Connection: Podcast Advice That Changed EverythingWhen I spotted a feature on podcasting in The Costco Connection, I was excited. When I saw Michelle Glogovac featured? I knew I had to reach out. That decision turned into one of the best moves I've made for growing my podcast.Michelle, THE Podcast Matchmaker®, publicist, and author of How To Get On Podcasts, shared simple, powerful strategies that helped expand my reach. One standout? Getting featured on other podcasts. It boosted my visibility, brought in new listeners, and gave me fresh insights into how other hosts run their shows.In this episode, Michelle shares her approach to storytelling, visibility, and the importance of showing up. Her message: Your story is your superpower.If you want to grow your platform and connect with more listeners, don't miss this one.“Your story is your superpower. The more you share it, the more people you help—and the more you grow in the process.”— Michelle Glogovac,The Podcast Matchmaker®. Michelle is terrific and you will hear and relate to her infectious personality. You'll want to be her best friend!Find out more or connect with Michelle:Author: How To Get On Podcasts Podcast Host: My Simplified LifeFounder and CEO: The MLG Collective Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV : Monday, June 2ndTimestamps00:00 Concentrated Liquidity and Trading Dynamics02:52 Community Building vs. Customer Generation06:08 Navigating Pre and Post TGE Strategies09:01 The Role of Oracles in DeFi11:55 Yield Opportunities in DeFi14:45 Hidden Gems and Overlooked Yields18:01 Balancing Risk and Return in DeFi21:04 Starting in DeFi: Tips for Newcomers36:46 Jacquelyn Intro and the Avalanche Summit39:01 Insights from Vlad at Robinhood41:23 Policymakers and the Future of Crypto44:10 Understanding the Anti-Crypto Sentiment46:31 Founding Token Relations49:11 The Role of Token Relations51:42 Macro Analysis and Its Impact on Crypto54:32 Fiscal Dominance and Bitcoin's Future01:00:46 Global Trade Dynamics and Bitcoin's Position01:05:22 July and August Market Predictions01:12:52 Navigating Fiscal Deficits and Currency Dynamics01:16:14 The Unsustainable Fiscal Path and Hyperinflation Concerns01:18:41 Running the Economy Hot01:22:36 Tariff Policies and Capital Controls01:23:39 The Rise of BRICS and Dollar Diversification01:24:37 Evaluating the Dollar Milkshake Theory01:26:07 Market Predictions and Seasonal Trends01:29:14 Multiplier: A New Player in DeFi01:35:10 User Experience and Conversion Strategies in DeFi01:42:07 Building a Successful Crypto BusinessThe Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Oral Arguments for the Court of Appeals for the Fifth Circuit
Penthol v. Vertex Energy
Alan Feld is the founder and managing partner of Vintage Investment Partners. Prior to founding Vintage, Alan Feld was a General Partner at Israel Seed Partners and at Vertex Ventures. Prior to Vertex, Alan was the Managing Director of Evergreen Capital Markets/Robertson Stephens Israel. Alan received an MBA from York University in Toronto, an L.L.B. from Osgoode Hall Law School in Toronto and a B.A. in Commerce and Finance from the University of Toronto.
The Rollup TV presents: Mammoth May.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.Former Chinook board member, Rouzbeh Haghighat, has been indicted for insider trading related to Novartis' $3.2 billion acquisition of the company. Despite this scandal, pharma R&D spending increased in 2024, climbing 1.5% across the global pharmaceutical sector. The acquisition of SiteOne by Lilly follows Vertex into the non-opioid pain space, providing diversification for Lilly, which has been focusing on obesity and diabetes treatments. Meanwhile, AbbVie's Allergan cuts over 200 staff after a botched marketing campaign, and Inflarx axes a rare skin disease study due to disappointing late-stage data.AGC Biologics will be at Bio International in Boston to showcase their global capabilities in drug production. Vaccine overhaul, rocket grounding, and drug price transparency are also highlighted in the latest news. Biogen's strategy for Zurzuvae shifts as obstetricians/gynecologists rise to the front lines. Drug price transparency in the US is discussed as being easier said than done. Additionally, Rocket's gene therapy for Danon disease is on hold after a patient death, and four biotechs are facing uncertainty in the COVID-19 vaccine landscape.Global pharmaceutical companies are increasing their research and development spending despite political and economic challenges. Biogen is shifting its strategy for the drug Zurzuvae as obstetricians and gynecologists become more involved. Drug price transparency in the US is still a challenge, despite efforts to increase transparency. Trilink has introduced a new poly(A) tail modification to enhance protein expression.In other news, a former Chinook board member has been indicted for insider trading, Trump has appointed Dr. Oz to lead drug pricing negotiations, and Lilly is following Vertex into non-opioid pain treatment with a SiteOne acquisition. Sanofi has purchased Vigil for $470 million to reignite an Alzheimer's target.
The Rollup TV presents: Mammoth May.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Live from Mix and Mingle Education Day: A Powerful Conversation with CaregiversIn this deeply moving live episode recorded at the Mix and Mingle Education Day, we brought together a powerful group of caregivers—grandparents, parents, stepparents, dads, and friends—for a heartfelt discussion about the emotional journey of caring for a loved one with cystic fibrosis.What started as a simple idea to gather voices turned into our most beautiful and emotional podcast yet. There were tears, laughter, and unforgettable stories. We were honored to be joined by a Grief Counselor who helped guide us through the complex feelings that surfaced during our conversation.This episode is a raw, real, and uplifting tribute to the strength, vulnerability, and love that caregivers bring to their roles every single day.Join us for a conversation that honors the heart of caregiving and the power of community.You'll hear from:(00:00:00) Laura Bonnell - Host - (Egypt, Foundation programs, legislation)(00:16:49) Lois Teicher - CF Grandmother (Laura's Mom) (00:19:05) Natalie Wicks Lois's partner(00:21:36) Julie Weatherhead - Grief Doula(00:28:45) Sharon Tischio - CF Mom(00:33:08) Cambria Whitaker - CF Mom in a queer/transgender relationship(00:38:55) Theresa Dagget, MSU Clinic, Respiratory Therapist, CF coordinator(00:49:00 ) Dorothy Stratford,CF Family Caregiver(00:52:15) Jillian Rogers Smith, 33 year old CF Patient and Dad, Bill Rogers (01:01:40) CF Mom to 6 year old daughter Louisa(01:07:28) Wendi Tague (Nurse Coordinator) and Claire Haglund (Social Worker) Present but not on the microphone were Joe Bonnell (Laura's husband), Jeannette Bovensie (Dorothy's Mom) and Dani Nettleton and daughter.Claire Haglund: CHaglund@dmc.orgWendi Tague: wtague@dmc.orgLois Teicher (Laura's Mom): Loisteicher@yahoo.comNatalie Wicks: Piccolo35@gmail.comTheresa Daggett: daggett3@msu.eduCambria Whittaker: cambriawhitta@gmail.comDorothy Straford: dstrat701@gmail.comSharon Tischio: stischio@comcast.netJamie Rudnycky: jamie.rudnycky@gmail.comJulie Weatherhead: weathervanecounseling@gmail.comJillian Smith, Jillian's Jay Walkers: jill@jilliansjaywalkers.org And Jillian's Dad, Bill Rogers Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV presents: Mammoth May.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV presents: Mammoth May.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Cystic Fibrosis and obesity? Until recently this has not been a topic of conversation for the CF community. The reason for obesity in the CF community is better health and longer lives, so the concern is now a reality. University of Michigan CF doctor, Carey Lumeng is researching the issue. As he says in this podcast, researchers have a lot to learn about the connection between better health in CF and obesity. We also talk about The Bonnell Foundation fellowship program. A few years ago we started the program to encourage doctors to work in the specialty field of cystic fibrosis. Dr. Lumeng is one of the doctors who oversees this program.Dr. Lumeng is the Frederick G.L. Huetwell Professor for the Cure and Prevention of Birth Defects and Professor in Pediatrics and Molecular and Integrative Physiology. Dr. Lumeng is the Division Chief of Pediatric Pulmonology at the C.S. Mott Children's Hospital and Associate Director of the Michigan MSTP Program.He grew up in Indiana and graduated from Princeton University in Molecular Biology. He received his PhD in Human Genetics and MD from the University of Michigan and completed residency training in Pediatrics in the Boston Combined Pediatrics Residency Program at Boston Children's Hospital and Boston Medical Center. He then completed fellowship training in Pediatric Pulmonology at the University of Michigan and started as faculty in 2006. He runs a research lab focused on the health effects of obesity and the links between metabolism and lung health. The laboratory participates in both basic science and translational research projects in adult and pediatric obesity. He is funded by the NIH and the CF Foundation for new projects studying the changing causes of diabetes in people with CF.To contact the CF pediatric department (the Bonnell girls are pictured on this page): https://www.mottchildren.org/conditions-treatments/cystic-fibrosis-pediatric?pk_vid=6ff46bd2d38fe04c1739891353f5b28b Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Welcome to The Rollup TV.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Welcome to The Rollup TV.The Rollup TV is brought to you by:Celestia: https://celestia.org/Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Omni Network: https://omni.network/Vertex: https://vertexprotocol.com/Frax: https://frax.com/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.The White House has announced a new drug pricing policy that includes the revival of the most favored nations rule and extends to the private markets, leveraging the patent system, drug importation, and more. Meanwhile, Lilly's Zepbound has been found to have a superior benefit-risk ratio compared to Novo's Wegovy, BMS and Sanofi settle a Plavix lawsuit with Hawaii for $700 million, and biopharma companies are focusing on developing a cure for HIV as federal funding for related research is being cut. Sino Biological offers comprehensive solutions for autoimmune diseases, and Roche promises a $300 million investment in China production after a multibillion-dollar investment in the US. On the other hand, Lexeo and IGM have both announced significant layoffs. Novartis CEO has expressed concerns about Trump's pricing controls.Funding for HIV-related research and infrastructure is being cut by the Trump administration, leading biopharma companies like Gilead and Immunocore to focus on finding a cure for HIV. In the field of neurology, there is a need for more precise diagnostic tools to effectively treat neurodegenerative conditions. The new HHS vaccine requirement has been criticized by leading vaccine physician Paul Offit as potentially being anti-vaccine activism disguised as policy. Companies like Novartis, Bayer, and AstraZeneca are exploring new indications and innovations in radiopharmaceuticals, hoping to capitalize on a market that could reach $16 billion by 2033. The FDA has faced delays in reviewing certain drugs, while biotech stocks have fallen after the appointment of Vinay Prasad to succeed Marks at CBER. Vertex has decided to abandon AAV in the gene therapy space.Upcoming events include a webinar on surviving and thriving in the biotech downturn. Job opportunities in the biopharma industry include positions at Takeda, Daiichi Sankyo, and AbbVie. Heather McKenzie, senior editor at BioSpace, is open to suggestions for future coverage topics in neuroscience, oncology, cell & gene therapy, metabolic, or other areas.
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
A 70-year-old person with cystic fibrosis. It's a phrase that wasn't just uncommon a few decades ago—it was virtually unheard of.When Luanne McKinnon was diagnosed in 1969 at just 13 years old, doctors told her parents she might live to be 19 years old. Today, Luanne stands on the edge of her 70th birthday—a milestone that not only redefines possibility but embodies resilience, creativity, and purpose.Born in Dallas, Texas in 1955, Luanne was diagnosed at a time when cystic fibrosis was still barely understood. No vests. No targeted medications. No community. And yet, she carved out a life of profound impact. “I stand as a witness to the possible.” says Luanne McKinnonAfter earning a Master of Fine Art in Painting and a PhD in Art History, she launched a celebrated career in the visual arts—owning an art dealership in New York City, directing major university museums, publishing works, and curating over 35 exhibitions. She even became a Fellow at the prestigious Getty Research Institute.And while that would be more than enough for most of us, Luanne continued to pour herself into advocacy—serving as Co-chair for Stanford's Patient and Family Advisory Committee, raising awareness for CF patients before and after transplant. In 2011, she underwent a successful double-lung transplant at Stanford, and fourteen years later, she is still very much living proof.This episode is not about her equally remarkable husband—EMMY award-winning filmmaker Daniel Reeve—though we'll mention him later. This is about Luanne—her life, her art, her truth, and her refusal to let a diagnosis define the limits of her possibility. She says, “I stand as a witness to the possible.”And after listening to this conversation, I think you'll believe in the possible, too.Welcome, to a very special episode of the Living with cystic fibrosis podcast and our incredible guest, Luanne McKinnon. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today is Tuesday, May 13th, 2025 Movement of Planets: Sun is at 23 degrees Taurus in the 12th house. Taurus' ruler Venus is in Aries in the 11th house. Aries' ruler Mars is in Leo in 4th house. Moon is at 2 degrees Sagittarius in the 7th house of love and relationships. Mercury is at 5 degrees Taurus in the 12th house. It opposes Black Moon Lilith in Scorpio in the 6th house. It also opposes the Vertex in Libra in the 6th house. Venus is at 8 degrees Aries in the 11th house of friendships and goals sextiles the MC in Aquarius. Mars is at 11 degrees Leo in the 4th house and Sesquiquadrate Saturn at 29 degrees in Pisces. Jupiter is at 23 degrees Gemini in the first house and trines the Vertex in Libra in the 6th house. Saturn is at the critical degree of 29 degrees in Pisces in the 11th house and sextiles the Taurus Ascendant. Uranus is at 27 degrees Taurus in the 12th house and conjuncts Hygiea at 27 degrees Taurus in the 12th House. Neptune is at 1 degree Aries in the 11th house and conjuncts the North Node in Pisces in the 11th house of friendships and goals. Pluto is at 3 degrees Aquarius retrograde and opposes Vulcanus Leo in the 3rd House. Chiron is at 24 degrees Aries in the 12th house of secrets and conjuncts Eris in Aries in the 12th house. Vesta is at 9 degrees Scorpio retrograde in the 6th house. Pallas is at 23 degrees Aquarius in the 10th house. Juno is at 24 degrees Scorpio retrograde in the 6th house. Ceres is at 28 degrees Pisces. The North Node is at 24 degrees Pisces Retrograde in the 11th house. The South Node is at 24 degrees Virgo Retrograde in the 5th house. Learn more about your ad choices. Visit megaphone.fm/adchoices
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.President Donald Trump has issued an executive order to expedite the timeline for building new facilities in the US while increasing inspections on foreign plants. Despite a drop in venture capital fundraising in the first quarter of the year, large investments are still being made in the pharmaceutical industry. Companies like BMS are investing billions in US manufacturing despite potential tariffs. Vertex has seen success with their non-opioid pain drug launch and biopharma venture capital fundraising has declined, but median deal sizes remain high. Lotte Biologics offers specialized ADC manufacturing services in Syracuse, NY. Other news includes Lilly's ALS pipeline expansion, states suing to block HHS cuts, and layoffs at PTC despite a Phase II win. Thank you for tuning in to today's episode of Pharma and Biotech daily. Let's dive into the latest updates from the industry.
In his effort to onshore manufacturing, President Donald Trump issued an executive order on Monday afternoon ordering the FDA to ease permitting processes for new and expanded U.S. facilities. The announcement comes as more and more Big Pharma companies commit billions to expanding their U.S. footprints. Bristol Myers Squibb CEO Christopher Boerner announced this week that the company will pump $40 billion into its stateside operations over the next five years, even as the pharma executes a massive cost-cutting effort that involves shaving $3.5 billion from expenses by 2027 and cutting thousands of jobs, including another 516 in New Jersey, according to a May WARN notice. In other policy news, the Department of Health and Human Services on Wednesday said it will require all new vaccines to be tested in placebo-controlled trials to earn FDA approval but some vaccine experts have raised concerns about this approach. Meanwhile, turmoil still envelopes the FDA, with staff cuts and rehires continuing at a dizzying pace. On Monday, several states sued HHS, saying that the cuts offload critical functions and costs onto the states and impede public health efforts. As Q1 earnings season for Big Pharma begins to wind down, there are still headlines coming from the biotech sector. Vertex revealed last week that it is abandoning all of its adeno-associated virus vector work, while BioNTech on Monday announced that tariffs could get in the way of its ambitious plans for a closely watched PD-L1-VEGF therapy. Moderna, meanwhile, continues its fall from COVID grace, missing Q1 revenue expectations and announcing plans to reduce operating expenses by around $1.5 billion by 2027. In the weight loss space, Novo Nordisk announced on Friday that the FDA has accepted the application for a pill version of Wegovy, with a decision expected this fall. Novo has also struck partnerships with CVS and Hims & Hers pharmacies to market injectable Wegovy, drawing the attention of Eli Lilly CEO David Ricks. Also this week, check out BioSpace's deep dives into advances in base editing—a technology that's been touted as a “safer” CRISPR—and Summit Therapeutics' push to bring closely watched PD-1/VEGF immunotherapy ivonescimab to the U.S. market after its recent approval in China.
Eight miles. Two friends. One cause.In this inspiring episode, Jacob Venditti opens up about his life with cystic fibrosis, offering candid updates on his health and the challenges he faces as he prepares for a lung transplant. He emphasizes the vital role of community support and shares how his work with the Live Fearlessly Foundation fuels his mission to empower others. Jacob also sheds light on the rare disease income threshold amendment he's championing, which aims to create more equitable opportunities for patients. The conversation builds toward his upcoming Crossing 4 CF event, showcasing his unwavering resilience and commitment to living fearlessly.The heartfelt conversation continues with Rob Brown. Rob talks about their upcoming 80-mile paddle race aimed at raising awareness for cystic fibrosis (CF). Jacob shares how open ocean paddling has become both a personal passion and a powerful way to connect with the CF community. Rob reflects on his enduring friendship with Jacob and their mutual love for surfing. Together, they highlight the healing power of the ocean—physically, mentally, and emotionally—especially for those living with CF. To connect with Jacob and his team: https://livefearlesslyfoundation.com Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Kintsugi, a Silicon Valley-based startup that helps companies offload and automate their sales tax compliance, has raised $18 million in new funding led by global indirect tax technology solution provider Vertex. The startup plans to enable more small and medium businesses to use its AI-enabled capabilities for tax calculations and filings. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Piyush Kharbanda, General Partner at Vertex Ventures, discusses his firm's AI investment thesis.
Join us on the latest episode, hosted by Jared S. Taylor!Our Guest: Peter Donnelly, CEO & Co-Founder at Genomics.What you'll get out of this episode:Genomics' Mission: Founded in 2014, Genomics is bridging cutting-edge genetic research with real-world healthcare solutions.Actionable Insights: Advances now allow actionable health insights for ~70% of people via genetic testing.Strategic Partnerships: Collaborations with companies like Vertex and GSK use genetics to improve drug targeting and trial outcomes.Insurance Innovation: Life insurers are early adopters of genetics to promote longevity and healthier lives.The Future Is Now: With global health systems under pressure, predictive genomics is primed to shift care from treatment to prevention.To learn more about Genomics:Website: http://www.genomics.com/ LinkedIn: https://www.linkedin.com/company/genomics-ltd/Our sponsors for this episode are:Sage Growth Partners https://www.sage-growth.com/Quantum Health https://www.quantum-health.com/Show and Host's Socials:Slice of HealthcareLinkedIn: https://www.linkedin.com/company/sliceofhealthcare/Jared S TaylorLinkedIn: https://www.linkedin.com/in/jaredstaylor/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.
From Clunky to Cutting-Edge: The Evolution of Airway Clearance with Nicole DunnWhen our daughters first received their vest machines, they felt like they weighed a hundred pounds and had to be plugged into the wall. The vests didn't fit well—riding high in the armpits and leaving much to be desired in comfort and function. Fast forward 25 years, and everything has changed.In this episode, Laura talks with Nicole Dunn, Senior Market Development and Education Manager at Tactile Medicaland an expert on the AffloVest. With a strong background as a registered respiratory therapist and a deep passion for respiratory education, Nicole is at the forefront of innovation in airway clearance therapy.Together, they dive into the evolution of the AffloVest—from its design improvements to the company's mission to provide accessible, life-changing therapy for people with chronic respiratory diseases like cystic fibrosis. Nicole shares how patient feedback has shaped product development, the impact of CF modulators on airway clearance, and how community engagement plays a vital role in Tactile Medical's approach.This episode is full of inspiration, real-life success stories, and a look at how far we've come in improving comfort, mobility, and quality of life for people with CF.To learn more about Tactile Medical please visit: https://tactilemedical.comTo learn more about AffloVest: https://affloVest.comFor questions: afflovestinfo@tactilemedical.com Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Black scholar and educator and American Enterprise Institute senior fellow Ian V. Rowe on why and how his Vertex schools are shaping low-income young people with moral foundations and optimism. Children in the Bronx are learning the four cardinal virtues and the personal agency which lead them into "the success sequence" that lifts kids out of poverty.Additional Resources: Book: Agency: The four point plan (F.R.E.E.) for all children to overcome the victimhood narrative and discover their pathway to power
CFRI's Executive Director, Siri Vaeth is sunshine to me. She's a dear friend.We met after Siri took on her role with the Cystic Fibrosis Research Institute. I consider Siri a dear friend, and a mentor. Siri is truly among the smartest people I know. She is an advocate for her daughter Tess, who has CF, and is an incredible advocate for the CF community. If you need legislation explained to you, Siri can help you. She can put it in a way you'd understand.Siri has a master's degree in social Welfare, she's fluent in Spanish, she's great at marketing and does a lot of public speaking…and is an all-around great person.This episode is packed with information about legislation, colon cancer, health insurance and discussion about the fact that people of color are under-diagnosed, concerns for the future of CF and catching up about our kids.To learn more about CFRI: https://www.cfri.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Thanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Darius Tabai is the CEO and co-founder of Vertex Protocol, a leading decentralized exchange built on Arbitrum. Darius is an experienced trader with a history of working in FX, Commodities, and Crypto. Darius' previous roles include the Head of Trading at JST Digital, Head of Trading at CrossTower, Global Head of Metals Trading at Merrill Lynch, and the Global Head of Precious Metals Trading at Credit Suisse.In this conversation, we discuss:- The story behind founding Vertex Protocol- What is a perp DEX?- Arbitrum's speed, low fees, and EVM compatibility- DeFi Infrastructure & UX Improvements- The competitive landscape of DEXs- What Makes Vertex Unique?- Tokenomics & Protocol Incentives- The rise and fall of memecoins- Liquidity across blockchains- Partnership with Berachain and SONICVertexWebsite: vertexprotocol.io X: @vertex_protocolTelegram: t.me/LiquidityLoungeDarius TabaiX: @DariusTabai --------------------------------------------------------------------------------- This episode is brought to you by PrimeXBT. PrimeXBT offers a robust trading system for both beginners and professional traders that demand highly reliable market data and performance. Traders of all experience levels can easily design and customize layouts and widgets to best fit their trading style. PrimeXBT is always offering innovative products and professional trading conditions to all customers. PrimeXBT is running an exclusive promotion for listeners of the podcast. After making your first deposit, 50% of that first deposit will be credited to your account as a bonus that can be used as additional collateral to open positions. Code: CRYPTONEWS50 This promotion is available for a month after activation. Click the link below: PrimeXBT x CRYPTONEWS50
We are thrilled to be sharing our veterinary podcast crossover series with you. Throughout these episodes, we are having conversations with other veterinary podcast hosts who are sharing why they started their podcast and their goals, as well as how we can all work together towards supporting our colleagues in this profession. Today our guests are Drs. Lisa Fortier and Sarah Wright. Dr. Fortier is the editor in chief for the AVMA and Dr. Wright is the associate editor for the AVMA journals. This is a great conversation to understand different ways to utilize “Veterinary Vertex” podcast and want to better understand what you can learn from each episode. They also share some of the bonus questions they add at the end of the episodes which does take us on a slight tangent as we discuss puzzles. If you want this and so much more, be sure to check out the entire episode! We want to share a big thank you to our sponsor CareCredit. You can learn more about Veterinary Patient Financing for Providers through CareCredit by visiting: https://www.carecredit.com/providers/animal-healthcare/ You can find Veterinary Vertex on all major podcasting platforms. Remember we want to hear from you! Please be sure to subscribe to our feed on Apple Podcasts and leave us a ratings and review. You can also contact us at MVLPodcast@avma.org Follow us on social media @AVMAVets #MyVetLife #MVLPodcast
Thanks so much for listening! For the complete show notes, links, and comments, please visit The Grey NATO Show Notes for this episode:https://thegreynato.substack.com/p/320-new-watches-2025The Grey NATO is a listener-supported podcast. If you'd like to support the show, which includes a variety of possible benefits, including additional episodes, access to the TGN Crew Slack, and even a TGN edition grey NATO, please visit:https://thegreynato.com/support-tgnSupport the show
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