POPULARITY
The challenges and triumphs of living with a rare disease. Leslie Baldwin shares her personal journey with Common Variable Immune Deficiency and Ehlers-Danlos Syndrome. You'll hear what fueled her passion for advocacy and the creation of Michigan Rare (MI-RARE). Together, they discuss the power of community, the importance of patient empowerment, and how collaboration with policymakers can expand access and resources for those living with rare conditions.TakeawaysAdvocacy is essential for the rare disease community.Building connections provides vital support.Patients should feel empowered to speak up for their health.Collaboration with policymakers can drive positive change.Storytelling inspires and unites the community.Engagement raises awareness and strengthens support networks.Advocacy days introduce rare disease issues to lawmakers.Recognizing unique challenges leads to better understanding.Coalitions amplify the collective voice of rare disease advocates.Empowering patients and caregivers enhances quality of life.About Leslie BaldwinA Michigan native now living in Holt, Leslie is a rare disease advocate. She co-founding MI-RARE, a foundation uniting rare disease voices across Michigan, alongside Kayla Miller, Kathi Luis, Kortney Lee, Chris Draper, and Laura Bonnell.Her advocacy experience is wide-ranging: she has worked with Autism Speaks, National Organization for Rare Disorders (NORD), The EveryLife Foundation, NIH, CMS, and the FDA. As Director of Strategic Advancement with Texas Rare Alliance, she helped pass key legislation that earned her national recognition as a finalist for the 2023 Rare Voice Award in State Advocacy.On September 30th, MI-RARE will host the Michigan Rare Disease State Advocacy Day at the Capitol, a powerful opportunity for patients, families, and caregivers to share their stories with lawmakers and demonstrate that while each condition may be rare, together we are many.To connect go to: MI-rare.org Register for Advocacy Day opens August 4th and ends September 12th, 2025. There is a travel stipend too. Go to the MI-Rare website.To connect with Leslie Baldwin: leslie@mi-rare.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Miss America 2025 Abbie Stockard: A Champion for Kids, Health, and Cystic FibrosisAbbie Stockard, Miss America 2025, joins us to share her incredible journey, from Auburn University nursing student and Tiger Paws dancer to national advocate and role model. At just 22, Abbie has earned over $89,000 in scholarships through the Miss America Opportunity and is using her platform to promote pediatric health, women's leadership, and awareness for cystic fibrosis (CF).Inspired by her best friend Maddie, Abbie has raised over $200,000 for CF research and was honored as the Cystic Fibrosis Foundation's “2024 Hero of Hope.” She also created High Five for Kids, a wellness program that empowers children—including those with chronic illnesses, to build healthy habits for life.In this episode, Abbie talks about balancing school, service, and advocacy, and how she's using her voice to drive real change in healthcare and beyond. Don't miss this inspiring conversation with a young woman leading with heart, purpose, and unstoppable energy. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Katana is a DeFi-optimized Layer-2 blockchain on Polygon, designed to consolidate liquidity and provide sustainable yields through integrated protocols like SushiSwap, Morpho, and Vertex. It features Chain-Owned Liquidity (CoL), reinvesting sequencer fees and app revenue to ensure deep liquidity pools and minimize slippage for users. The KAT token enables governance and incentivizes participation, and will soon drop.~This episode is sponsored by Tangem~Tangem ➜ https://bit.ly/TangemPBNUse Code: "PBN" for Additional Discounts!Guest: Justin aka @Crypto_Texan - DeFi Ecosystem Growth Lead at KatanaKatana Vault platform➜ https://bit.ly/KatanaVaults00:00 Intro00:10 Sponsor: Tangem00:40 Stablecoins on Polygon01:00 Katana growth01:20 Katana yield02:20 Katana and why Polygon needs it05:00 Core applications being used: morpho & sushiswap08:20 What is $AUSD 10:45 How often do rewards get distributed?14:00 TurtleClub: tracking rewards15:00 What other AggLayer chains should we be excited about?16:55 Bridging Gas Fees too high?20:35 When is $KAT token launch?22:30 Will Polymarket launch its own token, or enter agreement with Circle?24:10 Will AggLayer support tokenized stocks soon?25:45 Is $POL undervalued?27:00 Outro#Crypto #Stablecoin #Ethereum~Polygon Stablecoins Reaching Record Highs!
We returned from the Labor Day holiday to a spate of intriguing deals, including two that could surpass $2 billion: Vertex's new pact with Enlaza for autoimmune disease—which the Casgevy maker hopes could ease conditioning for the sickle cell/beta thalassemia gene therapy—and Novartis' agreement with Arrowhead for neurodegenerative diseases such as Parkinson's. But as we look ahead, Thursday's Senate Finance Committee will be the focus this week, as Health and Human Services Secretary Robert F. Kennedy Jr. will answer questions after the ousting of CDC Director Susan Monarez. Her departure is reportedly linked to changes to the regulation of COVID-19 vaccines, for which the FDA last week issued restricted approvals to Moderna, Pfizer/BioNTech and Novavax and rescinded the emergency use authorizations. The next ACIP meeting—where COVID-19 vaccines will be on the agenda—is set for Sept. 18 and 19. In the weight loss arena, Novo Nordisk presented results from a real-world study this weekend at the European Society of Cardiology Congress in Madrid showing that Wegovy cut the risk of heart attack, stroke or death by 57% compared to Eli Lilly's tirzepatide in people with obesity and cardiovascular disease. The company also continues to throw money into the space, last week inking a $550 million deal with Replicate for RNA-based treatments for obesity and diabetes. Meanwhile, Lilly is dropping studies of one oral obesity candidate as another nears a regulatory filing. Finally, the FDA greenlit the first GLP-1 generic for obesity. We also discuss reactions to the FDA's new guidance on radiopharma drug development, four recent approvals for rare diseases, and everything you ever wanted to know about SPACs.
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
What if a scan could do more than show you a picture, what if it could tell you a story about what's happening inside a child's body, in real time?That's exactly what Dr. Chris Flask is working to make possible.Dr. Flask is a Professor of Radiology, Biomedical Engineering, and Pediatrics at Case Western Reserve University and University Hospitals of Cleveland. He's at the forefront of an exciting transformation in medical imaging, one that could change the way we care for children with rare genetic diseases like cystic fibrosis (CF) and polycystic kidney disease (PKD).“Our goal is to turn imaging, instead of just image creation, into data,” says Dr. Flask. “We want to create numbers. So we can say, this is what's going on in the lungs. And when we put these patients on modulator therapies, we can see a 10 percent improvement in their lung disease. And similar responses in the pancreas, the liver, and the gut. That's our goal—quantifying it through this fingerprinting methodology.”This approach, MRI fingerprinting, is a revolutionary leap forward. Developed over the past decade at Case Western's MRI center, it's fast, accurate, and most importantly for kids: it requires no sedation, no radiation, and no contrast agents. Each image slice takes just 15 seconds, making it safer and more accessible for the most vulnerable patients.Dr. Flask's work is supported by the NIH, the Cystic Fibrosis Foundation, and an extraordinary 42-year collaboration with Siemens MRI. Together, they're paving the way for multi-center clinical trials using this technology to better understand disease progression and therapy outcomes.This episode is all about the intersection of science, innovation, and compassion, and the powerful impact of data-driven care.We're honored to welcome Dr. Flask to the show, although he prefers we call him Chris. You won't want to miss this deep dive into what's next for pediatric imaging and precision medicine.Share with anyone who's passionate about medical innovation, pediatric health, or rare disease research. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
"Cash is just a commodity. What truly attracts top entrepreneurs is the connection you build." Ashish Taneja completely flips the traditional investor-founder power dynamic in this eye-opening conversation with host Akshay Datt, revealing why the best founders actually choose their investors, not the other way around. Ashish Taneja is the Founding Partner & CEO of GrowX Ventures, one of India's pioneering deep tech venture capital firms. A Chartered Accountant who transitioned from being the India CEO of Vertex (a major UK BPO firm) to venture investing, Ashish has bootstrapped GrowX from angel investments in 2008 to managing ₹400+ crores across institutional funds. His portfolio includes a spectacular 17x return from spacetech company Pixxel, and notable exits to companies like Reliance and NASDAQ. With 49 investments and 9 successful exits over 15+ years, Ashish has become a leading voice in India's hardware and deep tech ecosystem. Key Insights from the Conversation:
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
“I always say that singing and performing was as much a part of my DNA as cystic fibrosis.” Julia RaeFrom the moment Julia Rae could speak, she was singing, and from the moment she could dream, she was already imagining a bigger stage. As her mother fondly recalls, at just two years old, Julia was watching Barney on TV and asked, “How do I get in there and do that with him?” That instinct, that pull toward performance, was never just about the spotlight. For Julia Rae, the stage became her sanctuary, and later, her platform for purpose.Diagnosed with cystic fibrosis at birth, Julia's life has never followed an easy script. But instead of letting a chronic illness limit her, she embraced the full range of her voice, as a singer, actress, writer, and advocate. She didn't just want to perform; she wanted to make a difference.At 16, Julia founded Singing at the Top of My Lungs, a nonprofit inspired by her own hospital experiences. Initially, the organization supported both CF research and creative therapies at children's hospitals. But as larger institutions took a stronger lead in research, Julia saw a growing gap elsewhere.“I've decided to devote all of Singing at the Top of My Lungs to music and creative art therapies... They are significantly underfunded, not covered by insurance, and they are often, honestly, the unsung heroes of children's hospitals.”Julia's foundation now champions music and art therapies — the very programs that once transformed her own stays in sterile hospital rooms into spaces of joy and creativity. She knows firsthand that healing isn't just about medicine — it's also about expression, play, and being seen as more than your diagnosis.Her own career blossomed when a YouTube performance caught the attention of a Beverly Hills record producer, leading to her single “Be That Girl” being featured in the film The Greening of Whitney Brown. She's since performed the national anthem at major sports arenas, starred in national commercials, and most recently, in the 2024 film Playing Through. Her appearance on ABC's Listen to Your Heart introduced her to a national audience, but she never let fame outshine her mission.In parallel with her artistic pursuits, Julia has become a tireless advocate. She co-created and hosted Making It Matterwith the Boomer Esiason Foundation, currently leads Uncommon Lungs with Vertex Pharmaceuticals, and recently launched a podcast called A Deeper Look, spotlighting bold, thoughtful conversations with inspiring women.Julia Rae is more than a performer, she's a force. Her life is a testament to what happens when passion meets purpose, and when a voice refuses to be silenced by circumstance.For the chronic illness community, and for anyone who's ever been told “you can't” — Julia's story sings a different tune.She's not just making music. She's making it matter. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
In der heutigen Folge sprechen die Finanzjournalisten Daniel Eckert und Holger Zschäpitz über einen Kursstolperer bei Hypoport, die Rallye Cannabis-Aktien und Mega-Verluste bei Softwaretiteln. Außerdem geht es um Hensoldt, Renk Group, Rheinmetall, Heidelberg Materials, Monday.com, Vertex, Twilio, ZoomInfo, OKTA, Mongo DB, Intuit, Workday, Snowflake, C3 AI, BigBear AI, Archer Aviation, AMC Enertainment, OpenDoor, Kohl's, Intuitive Machines, Tesla, Reddit, BitMine, Tilray Brands, Ørsted, BP, Shell, iShares Global Clean Energy Transition ETF (WKN: A0MW0M), PlugPower, Jinko Solar, SMA Solar, RWE, Enel, iShares iBonds Dec 2026 Term EUR Corporate ETF (WKN: A3EHAJ), Xtrackers II Target Maturity ETF EUR Corporate Bond (WKN: DBX0U6), Invesco Bullet-Shares 2027 EUR Corporate Bond ETF (WKN: A400MB) und iShares iBonds Dec 2028 Term ETF (WKN: A3EHAK). Wir freuen uns an Feedback über aaa@welt.de. Noch mehr "Alles auf Aktien" findet Ihr bei WELTplus und Apple Podcasts – inklusive aller Artikel der Hosts und AAA-Newsletter. Hier bei WELT: https://www.welt.de/podcasts/alles-auf-aktien/plus247399208/Boersen-Podcast-AAA-Bonus-Folgen-Jede-Woche-noch-mehr-Antworten-auf-Eure-Boersen-Fragen.html. Der Börsen-Podcast Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Hörtipps: Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. +++ Werbung +++ Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte! https://linktr.ee/alles_auf_aktien Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-discl
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.Vinay Prasad has returned to the FDA as the Chief of the Center for Biologics Evaluation and Research, just 10 days after his mysterious departure. His return comes after a short "vacation" in California, and it is believed that the regulator convinced him to come back. Some speculate that Prasad's time away may have helped him gain a better understanding of the complexities involved in decision-making at the FDA, especially when it comes to ensuring the safety of patients and meeting the needs of various stakeholders. This unexpected turn of events has generated interest and optimism among industry insiders.Gilead remains positive about the prospects of its HIV prevention drug, despite uncertainties surrounding recommendations from the U.S. Preventive Services Task Force. The FDA has launched a new program to help pharmaceutical companies lower regulatory barriers to manufacturing in the U.S. Other news includes Dewpoint Therapeutics slashing headcount, Novartis rumored to be taking over RNA specialist Avidity, and Trilink Biotechnologies offering process development services for nucleic acid therapeutic development. Lotte Biologics is expanding its global manufacturing bases, while other companies like Bicycle, Tune, and Iovance are downsizing to conserve cash. The FDA is in flux, Pfizer is discussing pricing with Trump, and Merck is cutting jobs. Vertex's next-generation pain drug failed in trials despite strong Q2 earnings. Thank you for listening to Pharma and Biotech daily: your source for quick updates on the latest news in the pharmaceutical and biotechnology industries.
On this week's episode, Grace Colón, John Maraganore, Paul Matteis and Eric Schmidt dive in with a discussion on policy news, including the pharma tariffs and latest on the Trump administration's Most Favored Nations drug pricing plans. The co-hosts then question if Vinay Prasad has a path back to the FDA and express hope for someone more centrist if he does not return. They also mention the CRLs for Scholar Rock and Regeneron were due to manufacturing issues. Continuing with policy news, they cover RFK Jr.'s decision to cancel ~$500 million in Biomedical Advanced Research and Development Authority (BARDA) contracts related to mRNA vaccine development. In data news, the group discusses Vertex's latest non-opioid pain data and the company's future in this therapeutic area. Next, the co-hosts highlight Alnylam's recently approved treatment for cardiomyopathy, noting it has surpassed consensus estimates and predicting mega-blockbuster status. A recent report on patient deaths among those who took Agios' Pyrukynd for anemia - though determined to be unrelated to the drug - is also discussed. The co-hosts then review Biogen's new “ventures” team, and the episode concludes with an overview of Novartis and Avidity deal rumors. *This episode aired on August 8, 2025.
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 - 07:22 - Opening & Market Update07:22 - 34:07 - Kyle from Milk Road34:07 - 01:08:50 - Karia Samaroo (xTAO/WonderFi)01:08:50 - 01:36:24 - Matt Katz from Caldera01:36:24 - 01:37:30 - Closing Remarks
Erfahre hier mehr über unseren Partner Scalable Capital - dem Broker mit Flatrate und Zinsen. Alle weiteren Infos gibt's hier: scalable.capital/oaws. Aktien + Whatsapp = Hier anmelden. Lieber als Newsletter? Geht auch. Das Buch zum Podcast? Jetzt lesen. Infineon verbessert sich. Pfizer spart. Vertex scheitert in Studie. Hims & Hers widerspricht Novo Nordisk. Alcon kauft Staar Surgical. Arista kann KI. AMD kann KI bisschen. Super Micro kann grad keine KI. Das PayPal und Amazon Südamerikas wächst und wächst. Nur die Marge von MercadoLibre (WKN: A0MYNP) tut das nicht. DHL (WKN: 555200) schlägt UPS & FedEx. Aber schlägt DHL auch den Markt? Diesen Podcast vom 06.08.2025, 3:00 Uhr stellt dir die Podstars GmbH (Noah Leidinger) zur Verfügung.
Center for Drug Evaluation and Research Head George Tidmarsh will oversee the Center for Biologics Evaluation and Research on an acting basis after Vinay Prasad's abrupt departure hours after the recording of last week's episode of The Weekly. While the situation is being billed as temporary, rumors are swirling that structural changes may be afoot at the FDA with Commissioner Marty Makary looking for better drug, biologic alignment.Meanwhile, the agency has come under criticism for another recent decision—one apparently driven by CDER's Oncology Center of Excellence director Richard Pazdur: the rejection of Replimmune's advanced melanoma drug, RP1. According to reporting by multiple outlets, Pazdur opposed the consensus opinion of CBER staff to approve the drug. The research team behind Replimmune's Phase III study penned an open letter to the FDA on Friday responding to the issues outlined in the agency's complete response letter. Meanwhile, the FDA's Sarepta saga continues, highlighting “unprecedented” FDA leaks and a veritable communications disaster.On the business side of biopharma, Q2 earnings continue to unfurl, with Pfizer, Vertex, BioNTech, Merck and Moderna all reporting this past week. Merck's $3 billion savings push has claimed 6,000 jobs, contributing to a brutal July that saw the entire biopharma industry axe 7,900 employees, a 487% year-over-year increase, based on BioSpace tallies. Meanwhile, Pfizer CEO Albert Bourla confirmed he has been in direct contact with President Donald Trump to negotiate a path forward on Most Favored Nation drug pricing after the president sent letters to 17 Big Pharma companies—and posted on his Truth Social platform—asking them to comply with the policy within 60 days or face potential unspecified consequences.In other policy news, the Centers for Medicare and Medicaid Services is reportedly considering coverage of GLP-1 drugs for weight management and obesity—reviving a Biden era proposal the Trump admin scrapped earlier this year.Finally, in BioPharm Executive this week, we have a special report on the situation in China as international drugmakers swoop into the region to find new drug candidates, while other companies build their therapeutic farm systems from incubators and venture arms. And check out BioSpace's brand new Manufacturing Brief, where we bring you the latest news and analysis in the area of biopharma manufacturing, starting with a feature on how to make cell and gene therapies commercially viable.
Never Just Surviving: Sophie Holmes on Running 36 Marathons with Cystic FibrosisDespite a schedule packed with training, advocacy, and breaking world records, Sophie Holmes of the U.K. always makes time to share her story, and we're so grateful she did.Diagnosed with cystic fibrosis at just four months old, Sophie was told she might not live past her teens. But rather than letting that define her, she's spent her life rewriting the narrative. Her latest, jaw-dropping accomplishment? Running 36 marathons in 36 days. That's right—36 consecutive days, 26.2 miles each day, driven by pure determination and an unshakable belief in what's possible.Sophie is not only an elite athlete and personal trainer, she's a powerful advocate for chronic illness awareness. In this episode of the Living with Cystic Fibrosis podcast, she talks about what fueled her through each grueling mile, how she manages the intense physical demands of endurance sports while living with CF.“Mindset is everything.” – Sophie HolmesIt's easy to say that exercise is one of the best things someone with CF can do. But Sophie reminds us: that doesn't mean it's easy. Her story is a powerful example of grit, strength, and living fully—even when the odds are stacked against you.Sophie's Story:Diagnosed with cystic fibrosis at four months oldTold she might not live past her teenage yearsRan 36 marathons in 36 days, demonstrating her extraordinary enduranceSet a Lake Cuomo Ultra Ironman World RecordBelieves mindset is the key to overcoming life's toughest challengesWorks as a personal trainer and chronic illness advocateRedefines resilience—not just surviving, but thrivingInspires runners, athletes, and anyone living with chronic illnessLives with relentless drive and purposeShows us what's possible when you push beyond the limits others set for youYou can find Sophie Holmes on IG: https://www.instagram.com/sophiegraceholmes/ Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 - 07:22 - Opening & Market Update07:22 - 34:07 - Kyle from Milk Road34:07 - 01:08:50 - Karia Samaroo (xTAO/WonderFi) 01:08:50 - 01:36:24 - Matt Katz from Caldera01:36:24 - 01:37:30 - Closing Remarks
Una nuova formula, un vero e proprio excursus, un viaggio guidati dalla bussola di Polo Nerd, un unico filo comune: il dopo, il futuro post-apocalittico.Guida ragionata a futuri che potreste non voler perdere (e in cui quasi sicuramente non vorreste vivere).--Merchandising:http://store.polonerd.netPer sostenerci offrendoci uno o più caffèhttps://www.buymeacoffee.com/polonerdSito, Mail e Contatti:redazione@polonerd.nethttps://www.polonerd.nethttps://www.polonerd.net/contattiPagina dell'episodio: https://www.polonerd.net/?p=1758
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 - Introduction02:01 - Current State of the Bull Market.05:01 - Insights on BTC and Ethereum trends.10:01 - Digital Asset Treasuries 15:01 - Arjun Bhatani on Digital Asset Flows.20:01 - Proof of governance with John Adler.25:01 - The Future of Yield in Crypto Apps.
“It's an honor to be an advocate,” says Laura Bonnell, founder of The Bonnell Foundation. “We are the government—people are. If we don't fight for fair laws that help the people they're meant to serve, who will?”In this episode, Laura is joined by five passionate advocates—some seasoned, some new—who recently traveled to Washington, DC, to meet with lawmakers. Together, they share their personal experiences, insights on advocacy, and why storytelling and persistence matter in influencing policy.The conversation highlights:How to build relationships with legislative staffThe role of personal stories in driving changeThe importance of staying organized and adaptableAdvice for those who can't travel but still want to advocateThe emotional and rewarding aspects of standing up for what mattersPlus, we're joined by a lineup of experts working at the intersection of science, innovation, and policy:Dr. Andy Kocab, VP of Research at ONL Therapeutics, shares how biotech is advancing treatments for retinal diseases. Contact: akocab@onltherapeutics.comHarold Chase, Director of Government Affairs at NSF, discusses his journey from Senate staffer to global health policy leader. Contact: hchase@nsf.orgThomas T. Moga, a veteran patent attorney and Fulbright Scholar, explains how intellectual property law impacts innovation. Contact: tmoga@dykema.comDr. Brandon McNaughton, CEO of Akadeum Life Sciences, offers insight on entrepreneurship, biotech breakthroughs, and customer-focused design. Contact: bhmcnaughton@gmail.comStephen Rapundalo, President of Michbio, reflects on bridging science, business, and public service. Contact: Stephen@michbio.orgThis episode is a powerful reminder that advocacy takes many forms—and every voice matters. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction 05:00 Tomer from Stellar 20:00 Shiv from Boundless35:00 Sreeram from EigenCloud50:00 Robinson Burkey from Wormhole01:05:00 Declan from Linea01:20:00 Michael from Nethermind01:35:00 Closing Remarks
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction02:15 Crypto Week in the USA10:45 Union's Big Announcement25:30 Securitize's Tokenization Journey40:00 Songcoins and Music Innovation55:00 Closing Remarks
Vertex is an open source nostr web of trust provider. Webs of trust are a method of quantifying verifiable reputations for spam mitigation, user discovery, social feeds, better app stores, and more.Pip on Nostr: https://primal.net/p/nprofile1qqs0dqlgwq6l0t20gnstnr8mm9fhu9j9t2fv6wxwl3xtx8dh24l4auswr6u0j Vertex on Nostr: https://primal.net/p/nprofile1qqstq4j6pk2sgaupru6l7ah9nq0dueafq356jllwcy7uzlek9yx7hlsel8nqn Vertex: https://vertexlab.io/ EPISODE: 167BLOCK: 905116PRICE: 847 sats per dollar(00:00:01) CNBC Intro(00:02:00) Happy Bitcoin Friday(00:04:27) Pip and Webs of Trust(00:06:49) Understanding Webs of Trust(00:14:16) App Store Security and Trust(00:18:53) Spam Mitigation(00:28:11) Client Side Solutions and Performance(00:35:33) Trust Models and Censorship Risks(00:45:02) Use Cases for Vertex(01:03:04) Relay Operations and Spam Control(01:11:01) Current State of the Nostr Ecosystem(01:17:10) Community Building and Onboarding(01:24:08) Closing Thoughts and Future PlansVideo: https://primal.net/e/nevent1qqs8vy4xuuny2hejghpjl57f77hh0t65gthaqhmjdwlwy7rr4ng3pzslchs0g support dispatch: https://citadeldispatch.com/donatenostr live chat: https://citadeldispatch.com/streamodell nostr account: https://primal.net/odelldispatch nostr account: https://primal.net/citadelyoutube: https://www.youtube.com/@CitadelDispatchpodcast: https://serve.podhome.fm/CitadelDispatchstream sats to the show: https://www.fountain.fm/rock the badge: https://citadeldispatch.com/shoplearn more about me: https://odell.xyz
We have a powerful conversation about dedication, innovation, and impact in the cystic fibrosis community in this podcast. I'm joined by two incredible guests from MVW Nutritionals: Mike Walters and Jason Vandiver.Mike Walters is a true pioneer in pharmaceutical business and innovation, with nearly four decades of experience. He began his career at Johnson & Johnson, where he spent 14 years in leadership roles across sales, marketing, and management development. In 1996, Mike launched his first company to help organizations navigate product commercialization in the U.S. Since then, his work in the CF space has been nothing short of groundbreaking. He founded and led Source CF, MVW Nutritionals, and CF Global Services, playing a key role in bringing many standard-of-care treatments to market. A Vanderbilt graduate with degrees in Biochemistry and Chemistry, Mike brings both scientific insight and a deep commitment to rare disease care.Joining him is Jason Vandiver, Chief Operating Officer of MVW Nutritionals. A proud Alabama native, Jason earned his degree in Finance from the University of Alabama at Birmingham and spent 16 years in banking before joining MVW during a time of rapid growth. He now helps lead the multimillion-dollar, family-owned company that's become a global leader in nutritional products for patients with CF and non-CF EPI.In this episode, Mike and Jason share their personal stories, the importance of strong partnerships, and the real challenges patients and families are facing—especially as funding landscapes continue to shift. We explore the power of empathy, the strength of community support, and why transparency in nonprofit operations matters now more than ever.It's a conversation about hope, action, and what's ahead as we work together to support those who need us most. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
In this episode RCP Medicine Podcast, we are joined by Dr John Dean, Clinical Vice President at the Royal College of Physicians and a physician in East Lancashire, and Dr John Ford, an academic public health doctor and Senior Clinical Lecturer at Queen Mary University. Together. They explore the multifaceted nature of health inequalities and discuss actionable steps physicians can take to address these disparities. Both share their personal experiences and professional insights into health inequalities and how it shaped their understanding of social and economic disadvantages. They discuss the structural factors within society that lead to health inequalities and emphasise the importance of creating a fairer, more inclusive society. The conversation focusses on the role of clinicians in addressing health care inequalities and the need for continuous improvement in healthcare design and delivery.ResourcesBridging the gap: a guide to making health inequalities a strategic priority for NHS leadersA snapshot of UK doctors: experiences of health inequalitiesSupporting clinicians to address health inequalities in practiceRCP view on health inequalities: a call to action for a cross-government strategyRCP LinksEducation and learning | RCP Events | RCP Membership | RCP Improving care | RCP Policy and campaigns | RCP RCP Social MediaInstagramLinkedInFacebookXBlueskyCreditsMusic by bensound.comFundingThis episode was funded by Vertex Pharmaceuticals (Europe) Limited. Vertex had no involvement in the creation and elaboration of this episode and all views and opinions expressed by the presenter and guests are solely their own.
Substack is where I discovered Dr. MeiLan Han! I was browsing through and was pleasantly surprised to read an article, and learn that she wrote a book called, Breathing Lessons. And to top it off, she's from my home state of Michigan. I also learned the Dr. Han's book was “a passion project during the pandemic.”I'm delighted to share a conversation with Dr. MeiLan Han, one of the country's most respected voices in lung health and a tireless advocate for people living with chronic respiratory conditions.Dr. Han is a Professor of Medicine and Chief of Pulmonary and Critical Care at University of Michigan Health. She's not only cared for patients at the bedside but has devoted her career to understanding lung disease at its roots, with a special focus on chronic obstructive pulmonary disease (COPD), a condition that remains widely under-recognized and underfunded. Through her research, Dr. Han is helping to uncover how diseases like COPD affect the lungs in different ways, with the goal of making treatment more precise, more effective, and more personalized.Her journey began at the University of Washington and continued through specialized training at the University of Michigan, where she also earned a Master's degree in Biostatistics and Clinical Study Design. Today, she leads research funded by the National Institutes of Health (NIH), serves on national advisory boards for the COPD Foundation and the American Lung Association, and contributes to global guidelines that shape how lung disease is diagnosed and treated.Dr. Han also serves as Deputy Editor of the American Journal of Respiratory and Critical Care Medicine, helping to guide the direction of clinical practice and research in pulmonary medicine.If you or someone you love is living with a chronic lung condition, Dr. Han's insight is not only encouraging, it's essential. I'm so grateful to bring her voice to this platform. How many breathes do we take in a lifetime? It's fascinating to discuss and you'll hear the answer in our podcast.Lung health, do you think about it?To get her book: https://www.amazon.com/Breathing-Lessons-Doctors-Guide-Health-ebook/dp/B08X2ZFGNZ/ref=tmm_kin_swatch_0 Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
High NRJ for your summer, much love !Peace Playlist : 1Matt Sassari / BLRThe Incident (extended mix) (5:51) 126 BPMTruesoul; 2BLR / Matt SassariClose Encounters (extended mix) (4:48) 128 BPMTruesoul; 3Carlo Lio / BorisJAQ (5:15) 131 BPMArcane; 4THE DEVIANTTNoir (5:27) 142 BPMSoma; 5DJ DextroBeautiful Day (4:59) 142 BPMMutual Rytm; 6JancenVertex (6:25) 142 BPMDrawner; 7Johannes AstrupSalsa Lessons (5:53) 142 BPMDrawner; 8DJ DextroMero Acaso (5:00) 142 BPMCodein Music; 9Genex / STIPPOut Of Turn (6:20) 144 BPMPlanet Rhythm; 10Confidential Recipe / DJ HausFlange Romance (4:32) 133 BPMDance Trax. minimal show on iTunes minimal show rss feed
Join clinical experts Cheryl Rosenfeld, DO, FACE, FACP, FSVM, ECNU, Madhuri M. Vasudevan, MD, MPH, FACE, and Diana Isaacs, PharmD, BCPS, BCACP, BC-ADM, CDCES, FADCES, FCCP, to learn how the AACE Patient Journey of Diabetes Technology supports people with diabetes in navigating their treatment options with confidence. This patient-friendly resource, developed from AACE clinical guidelines and reviewed by Diabetes Sisters, a leading patient advocacy organization, provides clear and accurate information on diabetes technologies, from glucose monitors to insulin delivery devices. The experts also highlight how members of the endocrine care team are using this tool to empower people with diabetes to manage their journey. This episode is brought to you with the support of Abbott, Novo Nordisk, Medtronic, and Vertex.
Monopolies! They're a problem as old as our country itself. On this week's TLDR, we talk to Denise Hearn and Vass Bednar, authors of The Big Fix: How Companies Capture Markets and Harm Canadians, about how Canadian companies got so big. And, we look at a surprising proposal for tackling the problem (at least in the airline industry). Plus, we explore how a new wonder drug could spell the end of the opioid epidemic. And, we watch as the pump and dump gets a makeover for the digital age.This episode was hosted by Devin Friedman, business reporter Sarah Rieger and former hedgefunder Matthew Karasz, with appearances by writers Vass Bednar and Denise Hearn. Follow us on other platforms, or subscribe to our weekly newsletter: linkin.bio/tldrThe TLDR Podcast is offered by Wealthsimple Media Inc. and is for informational purposes only. The content in the TLDR Podcast is not investment advice, a recommendation to buy or sell assets or securities, and does not represent the views of Wealthsimple Financial Corp or any of its other subsidiaries or affiliates. Wealthsimple Media Inc. does not endorse any third-party views referenced in this content. More information at wealthsimple.com/tldr.
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction04:54 Market Trends and Stablecoins07:18 Avi Patel and Kled Controversy18:39 AI and Token Economics30:02 Macro Economic Insights with Will Clemente52:11 Transitioning to New Guests and Topics54:06 Exploring Investment Trends in Crypto and AI55:59 The Future of Security in Crypto Transactions58:47 Self-Custody vs. Custodial Solutions in Crypto01:02:06 Institutional Interest in Staking and ETFs01:06:41 Research Trends and Contrarian Investments in Crypto01:09:06 Debating Proof of Stake and Governance Models01:12:51 Texas Bitcoin Reserve and Legislative Changes01:14:56 Debate on Central Limit Order Books and Infrastructure01:40:07 Exploring Hyperliquid and User Experience01:45:36 Interoperability and Application-Specific Rollups01:50:40 The Future of Composability in DeFi01:58:49 The Role of Trust in Autonomous Finance02:25:58 Agented Commerce and the Future of AI in Finance
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. The FDA's Center for Drug Evaluation and Research (CDER) head, Jacqueline Corrigan-Curay, is leaving the agency in July, becoming the latest in a series of FDA leaders to depart. Eli Lilly is facing concerns about gastrointestinal side effects for their weight loss pill, Orfoglipron, despite brushing off these worries. Vertex's cell therapy for diabetes shows promise, but questions remain about its market potential. HHS Secretary Robert F. Kennedy Jr. has restacked the CDC's vaccine advisory committee, claiming conflicts of interest within the previous group, which experts argue may impact the committee's apolitical nature. Prothena has downsized following a failure in an Al amyloidosis trial, and Novavax is adapting to regulatory uncertainty. Overall, the FDA is experiencing significant turnover in leadership, and challenges persist in drug development and regulation.
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction and Format Changes06:05 Meme Tweets and Community Engagement09:58 Market Analysis: Stablecoins and Trends11:22 Guest Segment: Trading Insights with Jake27:28 Security Concerns in Crypto29:10 Guest Segment: Insights from Reagan on Market Trends52:29 Exploring Zero-Knowledge Technology and Its Applications56:19 The Rise of Stablecoins in Emerging Markets59:38 The Future of Payment Solutions with Stablecoins01:03:57 Building Native Rollups and Their Impact on Ethereum01:09:51 The Shift Towards Revenue in DeFi Protocols01:23:19 Navigating Challenges in the Crypto Landscape01:34:28 Innovations in Internet Capital Markets with Dupe
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Global Tensions and Market Reactions04:40 Coinbase and Military Sponsorship Controversy06:09 Hyperliquid: The New Crypto Sensation?09:30 Eigen Layer and the Future of Decentralized Apps11:54 Kraken's New L2 Token: Ink and Market Dynamics15:19 AI Investments and Market Insights39:23 Market Analysis with TraderMain46:21 Market Sentiment and Altcoin Dynamics49:34 The Role of Movement Coins in Trading52:28 The Meme Coin Phenomenon and Its Implications53:51 Trading Strategies: Gainzy vs. Ansem58:22 The Evolution of Breakout and Prop Trading01:04:33 Diversifying Income in Crypto01:06:31 Comparative Analysis of Fart Coin and Hype Coin01:11:46 Market Positioning Ahead of FOMC01:14:10 Revenue Models in Crypto01:22:05 WorldCoin's Potential and User Distribution01:31:21 CoinFund's Investment Insights and Success Stories
"Oh, the people you'll meet, and the places you'll go..."That classic Dr. Seuss line couldn't have been more true when I found myself at a rare disease conference, taking with Dr. Gabriel Cohn. A quiet presence with a resume that reads like a roadmap through the last 30 years of rare disease breakthroughs, Dr. Cohn is the kind of person who reminds you just how much heart and science it takes to change lives.Dr. Gabe Cohn is the Executive Director and Medical Director of the Rosenau Family Research Foundation. He stepped into the role in October, bringing with him over three decades of experience that spans academic medicine and the biotechnology industry. A licensed, board-certified Clinical Geneticist and Obstetrician-Gynecologist, Dr. Cohn has contributed to the development of multiple therapeutics aimed at treating rare genetic disorders—a career built on both clinical precision and compassionate innovation.Beyond RFRF, he's also the Chief Medical Officer at iECURE, Inc., a biotech company pioneering gene editing therapies for rare diseases. His prior leadership roles at Homology Medicines, AVROBIO, OvaScience, and Shire reflect a steady focus on advancing gene therapy and editing platforms. Since 2017 alone, he's played a pivotal role in getting five different cell and gene therapy programs past the critical regulatory gatekeeping stages of IND and CTA submissions.Dr. Cohn isn't just a scientist—he's a builder, a connector, and a relentless advocate for the potential of genetic medicine to rewrite the future for patients with rare diseases.If you would like to get a hold of the Rosenau Foundation: https://rosenaufoundation.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The Rollup TV is brought to you by:Boundless: https://beboundless.xyz/AltLayer: https://www.altlayer.io/Mantle: https://www.mantle.xyz/Vertex: https://vertexprotocol.com/Subsquid: https://www.sqd.ai/Summer: https://summer.fi/Join The Rollup Family:Website: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd..Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+8ARkR_YZixE5YjBhThe Rollup Disclosures: https://therollup.co/the-rollup-disclTimestamps00:00 Introduction to The Roll Up TV and Guests01:13 Recent Market Developments and Token Collapses03:39 Bybit's Hybrid DEX Announcement06:05 ETF Filings and Staking Language09:00 Trump and Tron Going Public11:50 Introduction to Himanshu and Sentient12:35 The Vision Behind Sentient and Decentralized AI18:20 The Importance of Verification in AI24:29 Challenges in AI and Crypto Integration28:20 Innovative Projects within the Sentient Ecosystem33:05 DC Builder and Zero Knowledge Machine Learning40:56 Proof of Personhood and the Future of Identity44:33 Decentralized Identity and ZK Technologies50:02 AI in Crypto: Current Landscape and Innovations54:42 The Future of Identity Platforms and User Privacy01:00:08 Blockchain Bottlenecks: Execution vs. Consensus01:05:45 Institutional Interest Beyond Ethereum01:08:32 The Dynamics of On-Chain Speculation01:12:14 The Role of Wallets in User Retention01:18:52 The Future of Stablecoins and AI Integration01:28:51 The Future of Payments: Stablecoins vs. Real-Time Payment Networks01:35:33 The Role of FinTech in Crypto Payments01:36:30 Understanding the Value of Tokens in Crypto01:49:03 JP Morgan's Entry into Stablecoins01:52:20 Building a Brand: Azuki and the Anime Industry
187 - Mason Marangella (Vertex Effects) In episode 187 of “Have Guitar Will Travel”, presented by Vintage Guitar Magazine, host James Patrick Regan speaks with guitarist and owner and founder of Vertex Effects Mason Marangella. Tom Bukovac calls him “Sweet Mason”. In their conversation Mason tells us about his studio where he has a wealth of classic amplifiers, pedals, pedalboards and a crazy guitar collection with one of just about every type of guitar you would want and Mason tells us about where he gets stuff repaired when it's beyond what he can repair himself. Mason discusses his company Vertex Effects and what he does: buffers, boosts pedalboards all used by the top session guitarists as well as performing guitarists. Mason also talks about his YouTube channel and podcast “Chairmen of the Board” where Mason and his contemporaries discuss pedals, pedalboards and their components. Mason tells us how he initially got his pedals in to the hands of the top Nashville players and how he started in the field of pedals in the first place. Mason explains what a “buffer” does and the optimum pedal signal chain. Mason talks about a project he documented on YouTube having a Gibson R9 Les Paul transformed into a 1959 Gibson Les Paul the way 1956 Goldtop Les Pauls are transformed into the 1958 features and what the results were. Finally Mason takes us through what he's looking at for the future. . To find out more about Mason and Vertex Effects you can go to his website vertexeffects.com or the Vertex YouTube channel. Or check out “Chairmen of the Boards” wherever you listen to podcasts. . Please subscribe, like, comment, share and review this podcast! . #VintageGuitarMagazine #MasonMarangella #VertexEffects #BoutiquePedals #PedalBoards #FuzzBox #theDeadlies #BufferPedal #ChairmenoftheBoards #TomBukovac #haveguitarwilltravelpodcast #HGWT Please like, comment, and share this podcast! Download Link
Alan Feld is the founder and managing partner of Vintage Investment Partners. Prior to founding Vintage, Alan Feld was a General Partner at Israel Seed Partners and at Vertex Ventures. Prior to Vertex, Alan was the Managing Director of Evergreen Capital Markets/Robertson Stephens Israel. Alan received an MBA from York University in Toronto, an L.L.B. from Osgoode Hall Law School in Toronto and a B.A. in Commerce and Finance from the University of Toronto.