Podcasts about phenotyping

As the breed continues to make progress, the American Angus Association Board of Directors meets quarterly to provide direction on projects that will keep the Angus breed on top. This episode covered a lot of ground, including these topics: Ongoing research in Angus Genetics Inc., from validation studies to ongoing bovine congestive heart failure (BCHF) work  Crafting a data recognition program  Improvements to the GeneMax® test for commercial Angus females  AngusLink℠ success and packer feedback  A ribeye area specification adjustment for Certified Angus Beef (CAB)Changes to National Junior Angus Show competitions HOSTS: Miranda Reiman and Mark McCully GUESTS:  Jonathan Perry, chairman of the American Angus Association, has spent much of his life working in the purebred business.  In 1998, he came to manage the Deer Valley Farm's purebred program in Fayetteville, Tenn. As general manager, Perry developed an Angus program that balances all economically relevant traits in cattle that maintain structural soundness and phenotype. Each year, more than 500 bulls are marketed through three sales. Perry and his wife established the Hickory House restaurant in 2014, and it specializes in serving 100% CAB-branded product. Roger Wann, Poteau, Okla., was elected to the American Angus Association Board in 2022. He was raised on a multigenerational commercial cow-calf ranch. After the purchase of commercial Angus cows and one Angus bull, the benefits of Angus genetics became clear. After graduating from OSU, he earned a master's in physiology of reproduction from Texas A&M and began a career with ABS Global, where he helped cattle producers learn the value of efficient reproductive management programs. Wann Ranch hosts an annual production sale.He served on the board for the Oklahoma Cattlemen's Association and Oklahoma Angus Association and has helped develop its Angus feeder-calf sale.  John Stika, CAB president, leads the American Angus Association's consumer-facing subsidiary. The brand that is owned by registered Angus breeders and operates to create pull-through demand for Angus cattle has grown to more than 1.234 billion pounds of sales annually under his leadership. He joined CAB in 1999 in feeder-packer relations division, before working in business development and assuming the role of president in 2006. He's a Kansas farm boy, with degrees in animal and meat science from Kansas State University and the University of Kentucky.  RELATED READING: Close, But No Certification Angus Releases New Teat and Udder Research EPDs Angus Releases Cow Longevity Prediction AGI White Paper Looks at Future of Phenotyping, Commercial Data Producers to be Paid Grid Premiums for AngusLink Beef Scores Don't miss news in the Angus breed. Visit www.AngusJournal.net and subscribe to the AJ Daily e-newsletter and our monthly magazine, the Angus Journal.

In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation considers how the anticipated approval of a second MASH drug without biopsy might affect clinical trials and discusses two recent publications on patient genotyping and patient clusters. The conversation starts with Roger asking the group whether the presence of two approved MASH medications that do not require biopsy will make recruiting clinical trials that require them more challenging. The group doubts this will not add a significant new challenge to already-challenging trial recruitment. Naim comments that while this is a concern, it is already factored into trial schedules and that, given the number of patients available for trial, this should be highly manageable. Michelle discusses the importance of risk stratification in overall trial enrollment and this issue. Jeff and Mike agree that while this is a concern, it is part of a broader concern about the use of biopsy and should not in itself be a primary focus in terms of trial design at this point in time. Naim introduces two other topics he considers worthy of consideration: the impact of synergy between resmetirom and GLP-1 agonists and the importance of different genetic polymorphisms in predicting the impact of drugs on specific patients. On synergy, he comments that MAESTRO-NASH data suggests that the presence of a GLP-1 does not affect the impact of resmetirom on fibrosis level. On the second point, he notes that several papers looked at major genotypes like PNPLA3 and HD17N13 and specifically cites a late-breaker from Arun Sanyal indicating that g-allele status may impact MASH independent of weight or insulin. Michelle mentions a recent paper in Nature identifying distinct clusters of patients based on how their SLDs progress over time, with a two-cluster solution indicating patients with concomitant diabetes and obesity vs. those without these two concomitant diseases. Roger shares a key point from each paper on treatment in the US. Data in the PNPLA3 paper might suggest that the course of disease in Hispanics, who have high levels of g-allele abnormalities, might be different from other ethnic groups with far lower abnormality rates. He also notes that the faster disease progression in the non-metabolic cluster highlights the importance of learning more about Lean MASH and how to treat it, since faster progression of disease suggests later diagnosis and higher morbidity, mortality and treatment costs levels.

In this episode, Ferg is joined by Rudolph Linde, the Business Manager of Genetic Services at Meat & Livestock Australia (MLA), who shares his journey from diversified farming operations in South Africa to a career across New Zealand, the UK, and now Australia. With a strong passion for animal science and genetics, Rudolph delves into the principles of genetic improvement, the importance of variation, and how Australia's leading genetic databases are driving innovation in livestock production. He also explores advancements in reproductive technologies, such as IVF and sexed semen, and their role in improving animal welfare and sustainability, stressing the need to make genetic tools accessible to all producers, from early adopters to newcomers. This episode is essential listening for anyone interested in the future of livestock genetics and its impact on agriculture.How the breeder's equation underpins genetic improvement across all livestock species.The critical role of Australia's unparalleled genetic databases in driving innovation.The exciting potential of reproductive technologies for productivity and welfare.Making advanced genetics practical and accessible for producers of all levels.Head Shepherd is brought to you by neXtgen Agri International Limited. We help livestock farmers get the most out of the genetics they farm with. Get in touch with us if you would like to hear more about how we can help you do what you do best: info@nextgenagri.com.Thanks to our sponsors at MSD Animal Health and Allflex, and Heiniger Australia and New Zealand. Please consider them when making product choices, as they are instrumental in enabling us to bring you this podcast each week.Check out Heiniger's product range HERECheck out the MSD range HERECheck out Allflex products HERE

About the Guest Eric Psota is the Digital Innovation Manager at PIC North America. Since joining in 2021, he has been responsible for developing advanced technologies for digital phenotyping using computer vision and machine learning. Specifically, he specializes in multi-object tracking, pose estimation, animal identification, anomaly detection, real-time systems, and edge computing. Prior to joining […]

A mother and grandmother is brutally assaulted and murdered in her Salt Lake City Mormon bookstore. Her ties to wealthy Utah mogul Larry H. Miller have the public and the media in a panic. The cops investigate but soon, the case goes cold. Years later, something called Phenotyping becomes more available to the police and a diligent cold case cop named Ben Pender has a brilliant idea that will lead him on a quest with genealogists to find this monster.Support this podcast at — https://redcircle.com/dark-hearts-with-stacy-lee-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

“Mixing things up! Identifying early diversity benefits and facilitating the development of improved variety mixtures with high throughput field phenotyping” with Flavian Tschurr and Corina Oppliger. With increasing yield instability in monocropping systems due to diseases, pests or climatic factors, crop diversification is a potential strategy to improve crop performance and yield stability. However, crop diversification can present challenges in agronomic management and operations. One promising approach to crop diversification is using multiple varieties of one crop rather than multiple species. However, challenges remain in selecting suitable crop varieties and determining their optimum mixture rates. In this episode, graduate students Flavian Tschurr and Corina Oppliger share their insights on using image-based high-throughput phenotyping to optimize crop variety mixtures. Tune in to learn: ·         What is a crop variety mixture? ·         What are the benefits of crop variety mixture? ·         What is the use of high throughput phenotyping in crop improvement? ·         What is crop over-yielding? If you would like more information about this topic, this episode's paper is available here: https://doi.org/10.1002/ppj2.20090 This paper is always freely available. Contact us at podcast@sciencesocieties.org or on Twitter @FieldLabEarth if you have comments, questions, or suggestions for show topics, and if you want more content like this don't forget to subscribe. If you'd like to see old episodes or sign up for our newsletter, you can do so here: https://fieldlabearth.libsyn.com/. If you would like to reach out to Flavian Tschurr, you can find him here: flavian.tschurr@usys.ethz.ch If you would like to reach out to Corina Oppliger, you can find her here: corina.oppliger@usys.ethz.ch If you would like to reach out to Fiona Todd from our Student Spotlight, you can find her here: todd0179@umn.edu   Resources CEU Quiz: https://web.sciencesocieties.org/Learning-Center/Courses/Course-Detail?productid=%7bDDE42A24-8B81-EF11-AC21-000D3A3B1B33%7d Transcripts: Coming soon ETH Zurich, Institute for Agricultural Sciences: https://kp.ethz.ch/ ETH Zurich Mastadon: https://scicomm.xyz/@crop_science_eth ETH Zurich Instagram: https://www.instagram.com/crop.science.eth/ Field phenotyping platform- https://kp.ethz.ch/infrastructure/FIP.html Research paper on crop variety mixture - https://www.nature.com/articles/s41559-021-01497-x Field, Lab, Earth is Copyrighted by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.

Jacqui White is the Director of the Center for Biometric Analysis at The Jackson Laboratory. Her background in the clinical characterization of genetically altered mice coupled with her experience in establishing and running large operations critical to genetics research has been deeply beneficial to JAX and science. Jacqui was part of the 2024 Maine Science Festival, and her work is endlessly fascinating.Our conversation was recorded in June 2024. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle.The Discover Maine theme was composed and performed by Nick Parker.To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook InstagramMaine Science Festival on social media: Facebook Twitter InstagramMaine Science Podcast on social media: Facebook Twitter Instagram © 2024 Maine Discovery Museum

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on machine-learning for phenotyping and prognostication of myocardial infarction and injury in suspected acute coronary syndrome.

Dr. Marina de Koning Tijssen, the 2024 Stanley Fahn Presidential Lecture Award Winner, discusses her career history and how much she learned just by talking to patients. She also shares her views on the role of AI in the clinic and what legacy she hopes to leave for future movement disorders specialists.

Apple Phenotyping: The Tools Every Orchardist Needs In Episode 424 of Cider Chat, we dive deeper into the intricate world of apple identification, this time focusing on apple phenotyping — the art and science of describing apples by their physical characteristics. This is Part 3 of the three part series on John Bunker, renowned author, apple detective, and founder of FEDCO Trees. Expect a master class and experiential lesson as he shares his extensive experience and provides a valuable toolbox of techniques that for apple fans, cider makers and orchardist. What is Phenotyping? Apple phenotyping refers to the process of identifying and describing apples by their observable physical traits, such as size, shape, color, and texture. These characteristics, known as phenotypes, help orchardists distinguish between different apple cultivars. While apples may be genetically identical, they can exhibit slight variations based on their environment, making phenotyping a key skill for identifying and preserving apple varieties. Why is Apple Phenotyping Important? Phenotyping is more than just a way to describe apples; it's a critical method for orchard care, especially for those looking to preserve historic and rare apple varieties. John emphasizes that understanding the nuances of the apples you grow allows you to ensure that your orchard is correctly labeled and organized. This attention to detail not only improves the quality of your cider apples but also helps preserve the legacy of historic cultivars. Phenotyping also allows orchardists to confirm apple identities in cases where DNA testing isn't readily accessible or when historical records are incomplete. Whether you're comparing apples from different orchards or identifying a lost variety, having a reliable set of phenotyping techniques in your toolbox is essential. Watch this entire presentation at Cider Chat YouTube   The Orchardist's Toolbox: Key Techniques for Phenotyping John encourages orchardists to keep a thorough record of the apples they grow, noting characteristics such as: Size and Shape: Measure the diameter of the apple and observe its overall shape (e.g., round, oblate, or conic). Color and Skin: Note the ground color (the apple's underlying color) and any blushes, stripes, or russeting that appear on the skin. Stem and Cavity: Examine the length and thickness of the stem, as well as the depth and width of the cavity where the stem attaches. Calyx and Basin: Check whether the calyx (the dried flower at the apple's base) is open or closed, and assess the depth and shape of the basin around it. Core and Seeds: Cut the apple open to analyze the core's shape, size, and location, as well as the number and appearance of seeds. These observations not only help you identify your apples but also provide insights into the health of your orchard and the quality of your cider apples. Join the Conversation on Cider Chat YouTube To see John Bunker's full slideshow presentation on phenotyping apples and learn even more about his techniques, be sure to subscribe to the Cider Chat YouTube Channel. This episode is packed with invaluable knowledge for anyone looking to refine their skills in orchard care and apple identification. Mentions in this Cider Chat Episode 422 John Bunker Keynote: Orchards and Legacy Subscribe to Cider Chat YouTube Totally Cider Tour – French Cider Tour American Cider Association – CiderCon 2025

This conversation contains the first half of Roger Green's interview with PharmaNest Founder and CEO Mathieu Petitjean. After Matt tells the audience a little about his background and PhramaNest, the two discuss what Matt considered the key strategic takeaways for PharmaNest from the various EASL Congress presentations, abstracts and discussions. Before answering the question, Matt describes the core services his company offers: "PharmaNest specializes in digital pathology. Four years ago, we put down the hypothesis that the histological phenotype of fibrosis should be quantified in a high-resolution, sophisticated way." He goes on to state their core proposition for MASLD: "The big idea here is that fibrosis equals phenotype." He proceeds to describe his offerings in greater detail before offering the underlying value of computed histology: fibrosis is a continuous variable that is scored in discrete categories under the NASH-CRN model that drives FDA analysis. With this as context, he answers the question by describing three kinds of MASLD clinical trial designs. The first, earliest trials had a single pathologist reading histological slides. The method is not precise, but the drugs were not very good, and none were ultimately approved. The second set of trials relied on more rigorous methods for pathologists to read histology slides, with multiple readers and robust adjudication systems. Also, the drugs in this second set of trials were more efficacious, so that NASH-CRN, while a blunt instrument, could adequately assess efficacy. For the third set of trials, Matt believes non-invasive tests (NITs) are likely to suffice.

To date, no specific pharmacotherapy has proven effective against acute respiratory distress syndrome ARDS. Results on the research domain have been ineffective in human trials, a gap attributed in part to clinical and biological heterogeneity in human ARDS. Therefore, a precision medicine approach is intended to address explicitly how such underlying heterogeneity influences response to therapy among different patients with the same diagnosis. “You can find treatment for the disease but not for syndromes and ICU is a syndrome-forward approach to patient care” says Dr Pratik Sinha who is working on ARDS phenotyping. Listen to his interview and learn more about ARDS from disease understanding to future bedside perspectives.

Nutrition plays a vital role in the management of critically ill patients, and a tailored approach based on patient assessment, nutritional requirements, and clinical status is essential for optimising outcomes and promoting recovery.The concept of patient phenotyping and endotyping will help clinicians to better target nutrition interventions for a patient by categorising patients based on observable behaviours and underlying biological mechanisms, respectively.About these concepts, their clinical use and limitations we have interviewed Dr. Arthur Van Zanten. Listen to his explanations in our podcast offered by NEXT.

Dr. Abigail Wilson is interviewed by Tony Varela on her recent manuscript, "Pain Phenotyping and investigation of outcomes in physical therapy: An exploratory study in patients with low back pain.

Dr. Abigail Wilson (E-mail) is interviewed by Tony Varela on her recent manuscript, "Pain Phenotyping and investigation of outcomes in physical therapy: An exploratory study in patients with low back pain." This interview will be of interest to clinicians specializing in chronic pain, as well as, those caring for patients experiencing persistent lower back pain. Dr. Wilson's work on phenotyping, psychophysical testing, and conditioned pain modulation contributes to the evolution of pain management.  Here are is the other manuscript mentioned in the interview: 1) A psychophysical study comparing massage to conditioned pain modulation: A single blind randomized controlled trial in healthy participants Find out more about the Foundation for Orthopaedic Manual Physical Therapy (FOMPT) and the American Academy of Orthopaedic Manual Physical Therapists (AAOMPT) at the following links:Foundation website: www.aaompt.org/foundationAcademy website: www.aaompt.orgTwitter: @AAOMPTFacebook: https://www.facebook.com/aaompt/Instagram: https://www.instagram.com/officialaaompt/?hl=enPodcast e-mail: aaomptpodcast@gmail.comPodcast website: https://aaomptpodcast.simplecast.fm

Katie Murphy, Director of Phenotyping and Principal Investigator at the Donald Danforth Plant Science Center joins Megan Lynch talking about about what plants have to do with geospatial technology   (Photo credit - iStock/Getty Images Plus)

Dr. Arutha Kulasinghe discusses application of single-cell spatial phenotyping for characterizing the tumor microenvironment.

In this episode, Dr. Zanotti discusses advances in the management of cardiogenic shock. His guest is Dr. Jacob Jentzer, a cardiac intensivist trained in both Cardiology and Critical Care Medicine who practices full-time in the Cardiac Intensive Care Unit at Mayo Clinic in Rochester, MN. As the Director of Cardiac Intensive Care Unit Research at Mayo Clinic, he is active in Intensive Care Unit patient outcomes research, with a particular focus on the outcomes of patients with cardiogenic shock and cardiac arrest. Additional Resources Concise Definitive Review: Advances in the Management of Cardiogenic Shock. Jentzer JC et al. Crit Care Medicine 2023: https://pubmed.ncbi.nlm.nih.gov/37184336/ SCAI clinical expert consensus statement on the classification of cardiogenic shock. Baran DA, et al.: https://www.ncbi.nlm.nih.gov/pubmed/31104355 SCAI stages of cardiogenic shock stratify mortality risk. Jentzer JC et al.: https://www.ncbi.nlm.nih.gov/pubmed/?term=SCAI+stages+of+cardiogenic+shock+stratify+mortality+risk Advances in the Staging and Phenotyping of Cardiogenic Shock: Part 1. Jentzer JC, et al. JACC Advances 2022: https://www.jacc.org/doi/10.1016/j.jacadv.2022.100120 Machine Learning Approaches for Phenotyping in Cardiogenic Shock and Critical Illness: Part 2. Jentzer JC, et al. JACC Advances 2023: https://www.jacc.org/doi/10.1016/j.jacadv.2022.100126 Extracorporeal Life Support in Infarct-Related Cardiogenic Shock. ECLS-SHOCK Investigators. New Eng J of Med 2023: https://pubmed.ncbi.nlm.nih.gov/37634145/ Book Recommendations: The Hobbit by JRR Tolkien: https://bit.ly/44S0tZD The Lord of the Rings Trilogy by JRR Tolkien: https://bit.ly/45Q9NP0 The House of God. By Samuel Shem: https://bit.ly/48gnusc

As famed Iron Chef Alton Brown once said: “Everything in food is science”. In this week's episode, both of our storytellers discover something about themselves through the science of food. Part 1: Corn researcher Katie Murphy is scared becoming a TikToker will ruin her credibility as a serious scientist. Part 2: As a kid, Scottie Rowell gets an unpleasant surprise when they don't wait to eat their grandmother's pickles. Katie Murphy is a plant biologist who loves studying the inner workings of corn. She is the Director of Phenotyping and Principal Investigator at the Donald Danforth Plant Science Center, a non-profit research institute in St. Louis, Missouri. Her research group studies phenotyping, which means measuring the physical traits of plants. She holds a PhD in Plant Biology from UC Davis, and a Bachelor's in Chemistry from Stanford University. Katie's goal is to make a secure, sustainable food supply that can withstand future climates. She shares her research on TikTok @Real_Time_Science. Scottie Rowell is a Queer, Agender, Autistic artist based in Atlanta, GA. As a storyteller and puppeteer, Scottie's career is focused on performances and experiments in play in non-traditional theater spaces. As owner of Teller Productions, Scottie creates tactile, immersive experiences for families using sustainable materials (all repurposed, discarded, or easily recycled). Scottie's show Super Cello! premiered with the National Symphony Orchestra and the Kennedy Center for Performing Arts in April 2022. Other clients include the Georgia Aquarium, the Alliance Theater, the Center for Puppetry Arts, and the Atlanta Symphony Orchestra. Visuals and fun at ScottieRowell.com and TellerProductions.com. (Yes, Scottie made that pickle shirt for the story.) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.27.550830v1?rss=1 Authors: Schmutz, S., Commere, P.-H., Montcuquet, N., Cumano, A., Ait-Mansour, C., Novault, S., Hasan, M. Abstract: The analytical capability of flow cytometry is crucial for differentiating the growing number of cell subsets found in human blood. This is important for accurate immunophenotyping of patients with few cells and a large number of parameters to monitor. Here, we present a 43-parameter panel to analyze peripheral blood mononuclear cells from healthy individuals using 41 fluorescence-labelled monoclonal antibodies, an autofluorescent channel, and a viability dye. We demonstrate minimal population distortions that lead to optimized population identification and reproducible results. We have applied an advanced approach in panel design, in selection of sample acquisition parameters and in data analysis. Appropriate autofluorescence identification and integration in the unmixing matrix, allowed for resolution of unspecific signals and increased dimensionality. Addition of one laser without assigned fluorochrome resulted in decreased fluorescence spill over and improved discrimination of cell subsets. It also increased staining index when autofluorescence was integrated in the matrix. We conclude that spectral flow cytometry is highly valuable tool for high-end immunophenotyping, and that fine-tuning of major experimental steps is key for taking advantage of its full capacity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.14.549082v1?rss=1 Authors: Brahmer, A., Geiss, C., Lygeraki, A., Neuberger, E., Tzaridis, T., Nguyen, T. T., Luessi, F., Regnier-Vigouroux, A., Hartmann, G., Simon, P., Endres, K., Bittner, S., Reiners, K. S., Kramer-Albers, E.-M. Abstract: Extracellular vesicles (EVs) derived from the CNS are potential liquid-biopsy markers for early detection and monitoring of neurodegenerative diseases and brain tumors. This study assessed the performance of a bead-based flow cytometry assay (EV Neuro) for multiparametric detection of CNS-derived EVs and identification of disease-specific markers. Different sample materials and EV isolation methods were compared. Glioblastoma- and primary human astrocyte-derived EVs exhibited distinct EV profiles, with signal intensities increasing with higher EV input. Analysis of serum or plasma from glioblastoma, multiple sclerosis, Alzheimers Disease patients and healthy controls showed varying marker signal intensities. Notably, data normalization improved marker identification. Specific EV populations, such as CD36+EVs in glioblastoma and GALC+EVs in multiple sclerosis, were significantly elevated in disease compared to controls. Clustering analysis techniques effectively differentiated glioblastoma patients from controls. A potential correlation between CD107a+EVs and neurofilament levels in the blood was identified in multiple sclerosis patients. Together, the semi-quantitative EV Neuro assay demonstrated its utility for EV profiling in complex samples. However, reliable statistical results in biomarker studies require large sample cohorts and high effect sizes. Nonetheless, this exploratory trial confirmed the feasibility of discovering EV-associated biomarkers and monitoring circulating EV profiles in CNS diseases using the EV Neuro assay. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode of Arteetude, host Detlef Schlich takes listeners on a journey from ancient drum beats and smoke signals to the cutting-edge concept of digital phenotyping. We explore how our ancestors used patterns and symbols to communicate and how today, we're doing something similar but with our digital interactions.Detlef delves into the ethical implications of digital phenotyping, a tool that analyzes our digital interactions to understand our mental states. While it holds the potential to deepen our understanding of human psychology, it also poses challenges related to privacy and consent.Join us as we navigate these ethical minefields and discuss how we can use digital phenotyping responsibly. This episode is a thought-provoking exploration of how our use of symbols has evolved and how we can ensure that this new form of communication serves us, not the other way around.Apple Podcast https://podcasts.apple.com/us/podcast/arteetude-west-cork-s-first-art-fashion-design-podcast/id1527081647Spotify Podcasthttps://open.spotify.com/show/3eBv4E5qgW8Vot0oojAr1tArTEEtude is a podcast created and produced by Detlef Schlich that explores the intersection of art, digital culture, and true stories in West Cork. Schlich, a multi-disciplinary artist, operates his podcast with a cross-sectoral approach, believing that a visual artist should think beyond being just an antagonist and instead strive to be a protagonist. Through this podcast, he dives into the unknown depths of the creative mind to uncover new perspectives and ideas.Detlef Schlich is a podcaster, visual artist, filmmaker, ritual designer, and media archaeologist based in West Cork. He is recognized for his seminal work, including a scholarly examination of the intersections between shamanism, art, and digital culture, as well as his acclaimed video installation, Transodin's Tragedy. He primarily works in performance, photography, painting, sound, installations, and film. In his work, he reflects on the human condition and uses the digital shaman's methodology as an alter ego to create artwork. His media archaeology is a conceptual and practical exercise in uncovering the unique aesthetic, cultural and political aspects of media in culture.WEBSITE LINKS Detlef SchlichInstagramDetlef Schlich ArTEEtude I love West Cork Artists FacebookDetlef Schlich I love West Cork Artists Group ArTEEtudeYouTube Channelsvisual PodcastArTEEtudeCute Alien TV official WebsiteArTEEtude Detlef Schlich Det Design Tribal Loop Download here for free Detlef Schlich´s Essay about the Cause and Effect of Shamanism, Art and Digital Culturehttps://www.researchgate.net/publication/303749640_Shamanism_Art_and_Digital_Culture_Cause_and_EffectSupport this podcast at — https://redcircle.com/arteetude-a-podcast-with-artists-by-detlef-schlich/donations

In this episode Cyrill Stachniss, professor at the University of Bonn and spokesperson of the DFG Cluster of Excellence “PhenoRob - Robotics and Phenotyping for Sustainable Crop Production” sheds light on the purpose and focus of PhenoRob. Gain insights into the importance of optimizing field management with digital technologies like robotics or machine learning. How can we analyze every plant at high speed to provide management and automatic target actions for every plant. Are there different complexity levels in analyzing and taking actions? What methods, applications and technologies are used to analyze the data? What's the technological outlook for the next 5-10 years? Cyrill Stachniss is a full professor at the University of Bonn and heads the Photogrammetry and Robotics Lab. He is additionally a Visiting Professor in Engineering at the University of Oxford and is with the Lamarr Institute for Machine Learning and Artificial Intelligence. Cyrill is a spokesperson of the DFG Cluster of Excellence “PhenoRob - Robotics and Phenotyping for Sustainable Crop Production” at the University of Bonn. Before his appointment in Bonn, he was with the University of Freiburg and the Swiss Federal Institute of Technology, ETH Zurich. The research activities of the Photogrammetry and Robotics Lab focus on probabilistic techniques for mobile robotics, perception, and navigation. This involves developing and applying state estimation, machine learning, and AI algorithms for robots and sensor data interpretation. The team has made several contributions to SLAM, localization, place recognition, semantic scene interpretation, autonomous exploration, and navigation. The main application areas of the lab are autonomous service robots, agricultural robotics, and self-driving cars. Besides his university involvement, he co-founded three startups: Escarda Technologies, DeepUp, and PhenoInspect. https://www.phenorob.de/ https://www.youtube.com/c/CyrillStachniss?

CME credits: 1.75 Valid until: 31-05-2024 Claim your CME credit at https://reachmd.com/programs/cme/phenotyping-the-ild-ph-patient-to-determine-treatment-strategy/15568/ In late 2022, the ERS/ESC issued new guidances for screening, diagnosis, and treatment of all forms of pulmonary hypertension. The new guidelines insist on regular and consistent risk assessment for all patients, not just for initial diagnostic purposes but for monitoring and management once a diagnosis is made. This program covers numerous aspects of the new ERS/ESC guidelines, with some practical examples and a focus on Group 1 PAH and other forms. New diagnostic approaches are considered, and accurate and complete cardiac imaging is a focus.

Dr Silvia Radenkovic, Professor Eva Morava and Professor Kent Lai join the podcast to discuss recent insights that may enable prognostication in PGM1-CDG, and a promising gene therapy study that could address the cardiomyopathy that remains untreated by Galactose therapy. The role of PGM1 isoform 2 in PGM1-CDG: One step closer to genotype–phenotype correlation? Silvia Radenkovic, et al https://doi.org/10.1002/jimd.12601 Interested listeners may want to read gene therapy paper discussed herein: https://doi.org/10.1016/j.trsl.2023.01.004

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.03.539324v1?rss=1 Authors: Iglesias, A. G., Chiu, A. S., Wong, J., Campus, P., Li, F., Liu, Z., Patel, S. A., Deisseroth, K., Akil, H., Burgess, C. R., Flagel, S. Abstract: The survival of an organism is dependent on their ability to respond to cues in the environment. Such cues can attain control over behavior as a function of the value ascribed to them. Some individuals have an inherent tendency to attribute reward-paired cues with incentive motivational value, or incentive salience. For these individuals, termed sign-trackers, a discrete cue that precedes reward delivery becomes attractive and desirable in its own right. Prior work suggests that the behavior of sign-trackers is dopamine-dependent, and cue-elicited dopamine in the nucleus accumbens is believed to encode the incentive value of reward cues. Here we exploited the temporal resolution of optogenetics to determine whether selective inhibition of ventral tegmental area (VTA) dopamine neurons during cue presentation attenuates the propensity to sign-track. Using male tyrosine hydroxylase (TH)-Cre Long Evans rats it was found that, under baseline conditions, ~84% of TH-Cre rats tend to sign-track. Laser-induced inhibition of VTA dopamine neurons during cue presentation prevented the development of sign-tracking behavior, without affecting goal-tracking behavior. When laser inhibition was terminated, these same rats developed a sign-tracking response. Video analysis using DeepLabCut revealed that, relative to rats that received laser inhibition, rats in the control group spent more time near the location of the reward cue even when it was not present and were more likely to orient towards and approach the cue during its presentation. These findings demonstrate that cue-elicited dopamine release is critical for the attribution of incentive salience to reward cues. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.04.539430v1?rss=1 Authors: Vogelgsang, J. S., Dan, S., Lally, A. P., Chatigny, M., Vempatia, S., Abston, J., Durning, P. T., Oakley, D. H., McCoy, T. H., Klengel, T., Berretta, S. Abstract: INTRODUCTION: Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to postmortem work, as assessment of newly developed phenotypic concepts needs to rely on existing records. METHODS: We adapted well-validated methodologies to compute NIMH research domain criteria (RDoC) scores using natural language processing (NLP) from electronic health records (EHRs) obtained from post-mortem brain donors and tested whether RDoC cognitive domain scores were associated with hallmark Alzheimers disease (AD) neuropathological measures. RESULTS: Our results confirm an association of EHR-derived cognitive scores with hallmark neuropathological findings. Notably, higher neuropathological load, particularly neuritic plaques, was associated with higher cognitive burden scores in the frontal (beta=0.38, p=0.0004), parietal (beta=0.35, p=0.0008), temporal (beta=0.37, p=0. 0004) and occipital (beta=0.37, p=0.0003) lobes. DISCUSSION: This proof of concept study supports the validity of NLP-based methodologies to obtain quantitative measures of RDoC clinical domains from postmortem EHR. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

“Cost-effective, high-throughput phenotyping system for 3D reconstruction of fruit form” with Dr. Mitchell Feldmann Various research and breeding programs study phenotypical traits—or traits that can be discerned via the five senses—to evaluate the quality of their target crops. However, getting data on these traits, often via human-made measurements, can be time-consuming, subjective, and inaccurate, hampering research efforts. This episode of the Field, Lab, Earth podcast, Mitchell discusses his work developing a high-throughput, affordable way to capture one important phenotypical trait: fruit shape. Tune in to learn: Why it's important to accurately measure fruit shape How consumers consider shape, size, and color when making purchasing decisions How Mitchell and his partner developed their system What kinds of fruits and other shapes they tested If you would like more information about this topic, this episode's paper is available here: https://doi.org/10.1002/ppj2.20029 This paper is always freely available. Contact us at podcast@sciencesocieties.org or on Twitter @FieldLabEarth if you have comments, questions, or suggestions for show topics, and if you want more content like this don't forget to subscribe. If you'd like to see old episodes or sign up for our newsletter, you can do so here: https://fieldlabearth.libsyn.com/. If you would like to reach out to Mitchell, you can find him here: mjfeldmann@ucdavis.edu https://twitter.com/mitchfeldmann If you would like to reach out to Jagdeep Singh from our Student Spotlight, you can find him here: jzs0217@auburn.edu https://twitter.com/jagdeep_pb23 Resources CEU Quiz: https://web.sciencesocieties.org/Learning-Center/Courses/Course-Detail?productid=%7b79C6CDDE-6393-ED11-AAD1-000D3A365051%7d Transcripts: https://www.rev.com/transcript-editor/shared/1GsNmx-nLICM_FERf27w5HimLSq7NbiVysGu0YMlKNX1owc_3HgKQ5kWM4gZ9AlolpWD5QpV7vOTvZIXsGlydsgKoOo?loadFrom=SharedLink Thingiverse: https://www.thingiverse.com/ Mitchell's Sound Cloud: https://soundcloud.com/vug_01 Sponsored by METER Group. METER sensors deliver real-time, plant, soil, and atmospheric data that fuels environmental research. Listen to METER Group's new podcast We Measure the World to hear how innovative researchers leverage environmental data to make our world a better—and more sustainable—place at metergroup.com/fieldlabearth Field, Lab, Earth is Copyrighted by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.12.523760v1?rss=1 Authors: Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D., Khosla, S. Abstract: Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we applied mass cytometry by time-of-flight (CyTOF) using carefully validated antibodies to analyze senescent cells at single-cell resolution. We used multiple criteria to identify senescent mesenchymal cells that were growth arrested and resistant to apoptosis (p16+/Ki67-/BCL-2+; p16KB cells). These cells were highly enriched for senescence-associated secretory phenotype (SASP) and DNA damage markers and were strongly associated with age. p16KB cell percentages were also increased in CD24+ osteolineage cells, which exhibited an inflammatory SASP in aged mice and were robustly cleared by both genetic and pharmacologic senolytic therapies. Following isolation, CD24+ skeletal cells exhibited growth arrest, SA-beta gal positivity, and impaired osteogenesis in vitro. These studies thus provide a new approach using multiplexed protein profiling by CyTOF to define senescent mesenchymal cells in vivo and identify a highly inflammatory, senescent CD24+ osteolineage population cleared by senolytics. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Pratik Sinha, MBChB, PhD, is an Assistant Professor in the Department of Anesthesiology at the Washington University School of Medicine in St. Louis. Dr. Sinha's current research interests are in using big data analytics to identify biologically-driven homogeneous subgroups within heterogeneous critical-illness syndromes, with applications in precision medicine. For our Critical Care Grand Rounds, Dr. Sinha presents a lecture entitled "Personalized Treatments in ARDS: Can Phenotyping Help?"

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.23.517711v1?rss=1 Authors: Murakami, T. C., Heintz, N. Abstract: The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods to studies of human brains has been difficult due to their structural variability and the lack of standardized quantitative metrics. Here we report a rapid and scalable staining/imaging technique, termed mFISH3D, that enables single-cell-resolution imaging of mRNAs of more than ten genes in a large mammalian brain. To apply mFISH3D to postmortem human cerebral cortex, we have reconstructed morphogenic tracks of cortical growth, and used the tracks to provide a framework for quantitative assessment of cytoarchitecture. The workflow enabled the objective quantification of biological heterogeneity among cortical regions. We propose these techniques for standardization of 3D histology of the human cortex to provide reproducible measurements of cell-type-specific neuroanatomy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

TM News 129 - Counting Votes, Enceladus, Duck on Mars, Recession, Alex Jones, DNA Phenotyping...http://www.troubledminds.org Support The Show! https://rokfin.com/creator/troubledminds https://troubledfans.com/ https://patreon.com/troubledminds https://www.buymeacoffee.com/troubledminds https://www.twitch.tv/troubledmindsradio #aliens #conspiracy #paranormal --------------------------------------------------------------------------------------A nation waits: U.S. election workers toil to count thousands of voteshttps://www.msn.com/en-us/news/politics/a-nation-waits-us-election-workers-toil-to-count-thousands-of-votes/ar-AA140TWXIs It True That Every Vote Used To Be Counted on Election Night? | Snopes.comhttps://www.snopes.com/fact-check/election-night-votes-counted/Scientists Tested Einstein's Relativity on a Cosmic Scale, And Found Something Odd : ScienceAlerthttps://www.sciencealert.com/scientists-tested-einsteins-relativity-on-a-cosmic-scale-and-found-something-oddNASA Heat Shield That Could Land Humans on Mars Aces Space Test Ride - CNEThttps://www.cnet.com/science/space/nasa-heat-shield-that-could-land-humans-on-mars-aces-space-test-ride/Newly Discovered Protein Partners Could Heal the Hearthttps://scitechdaily.com/newly-discovered-protein-partners-could-heal-the-heart/https://www.scmp.com/news/china/science/article/3199043/chinese-particle-collider-takes-scientists-one-step-closer-figuring-out-worldFish 'Look Down' When They Swim, And We Finally Know Why : ScienceAlerthttps://www.sciencealert.com/fish-look-down-when-they-swim-and-we-finally-know-whyIn the line of fire: Octopuses hurtle jet-propelled shells at each other - India Todayhttps://www.indiatoday.in/science/story/in-the-line-of-fire-octopuses-hurtle-jet-propelled-shells-at-each-other-2296127-2022-11-11Police Use DNA Phenotyping to Limit Pool of Suspects to 15,000https://www.vice.com/en/article/y3pkgj/police-use-dna-phenotyping-to-limit-pool-of-suspects-to-15000https://astronomy.com/news/2022/11/saturns-moon-enceladus-may-be-more-habitable-than-thoughtAmazon Released Warehouse Robot Sparrow and It Could Wipe Out Jobshttps://www.businessinsider.com/amazon-released-warehouse-robot-sparrow-it-could-wipe-out-jobs-2022-11Bizarre! A duck! On Mars? Look what NASA Curiosity Rover just shot | Tech Newshttps://tech.hindustantimes.com/tech/news/bizarre-a-duck-on-mars-look-what-nasa-curiosity-rover-just-shot-71668071171678.htmlCryptography's Future Will Be Quantum-Safe. Here's How It Will Work. | Quanta Magazinehttps://www.quantamagazine.org/cryptographys-future-will-be-quantum-safe-heres-how-it-will-work-20221109/Meta Quest Pro review: get me out of here - The Vergehttps://www.theverge.com/23451629/meta-quest-pro-vr-headset-horizon-reviewhttps://www.nytimes.com/2022/11/11/business/economy/uk-eu-economy-recession.htmlStar Wars Fans Are Saying Andor Is Better Than The Empire Strikes Back?https://www.giantfreakinrobot.com/ent/star-wars-andor-better-than-empire.htmlhttps://www.nytimes.com/2022/11/10/us/politics/alex-jones-sandy-hook-damages.htmlA New Way To Lose Weight Could Change Your Metabolismhttps://scitechdaily.com/a-new-way-to-lose-weight-could-change-your-metabolism/Evening People Show Enhanced Fear Acquisition, Which May Increase the Risk to Develop Anxiety - Neuroscience Newshttps://neurosciencenews.com/chronotype-fear-anxiety-21812/Chemists create an 'artificial photosynthesis' system ten times more efficient than existing systemshttps://phys.org/news/2022-11-chemists-artificial-photosynthesis-ten-efficient.htmlhttps://nautil.us/how-i-learned-to-stop-worrying-and-love-uncertainty-245816/

Dr Alan Cronemberger Andrade narrates his blog written for Dementia Researcher. Digital interactions could be useful for tracking health states, especially for brain disorders. The problem is that this kind of data may be harder to protect, and less controlled by ourselves. People with dementia, and other cognitive and behavioural problems, are vulnerable to data insecurity. In this blog Alan describes what digital phenotyping is.. the good and bad aspects of using it, and some future perspectives behind ethical and methodological difficulties. Healthcare professionals and non-clinical researchers need to talk more about that. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-digital-phenotyping-in-dementia-and-neurology-we-have-questions/ -- Dr Alan Cronemberger Andrade is a Neurologist and MSc Student in Neurology and Neuroscience at the Federal University of São Paulo in Brazil. He takes care of patients with neurological problems in diverse settings, and studies how digital technology interacts with the human brain in health and disease, focused on dementia and related disorders. His aim is to find how useful digital technologies could be in the near future, helping dementia patients and their caregivers. He loves writing, travelling, and reading about curious facts of ancient history. If you would like to write for us, or join out team of regular contributors, drop us a line - dementiaresearcher@nihr.ac.uk

Commentary by Dr. Candice Silversides and Dr. Jacob C. Jentzer

Commentary by Dr. Candice Silversides and Dr. Jacob C. Jentzer

In episode 1360, Jack and Miles are joined by host of Articles of Interest, Avery Trufelman, to discuss…. Student Performance Scores Are Down, Blame the Teachers' Unions? Maybe The Police Are A Bad Idea Pt 2: DNA Mugshots Are Racist BS, Sprezzatura/Menswear and more! Student Performance Scores Are Down, Blame the Teachers' Unions? School Closures Were a Failed Policy Maybe The Police Are A Bad Idea Pt 2: DNA Mugshots Are Racist BS Edmonton police use DNA phenotyping as ‘last resort' in hopes of identifying sexual assault suspect Edmonton police issue apology for controversial use of DNA phenotyping Building a Face, and a Case, on DNA NYPD still using controversial DNA lab for investigations more than a year after City Hall said ties were cut Sprezzatura/Menswear LISTEN: Penelope Freestyle by Baby FatherSee omnystudio.com/listener for privacy information.

On January 7th, 1972, Nancy Anderson, 19, is found dead in her Waikiki apartment with over 60 stab wounds. The case goes cold for fifty years until new DNA technology and detective work leads to the arrest of a suspect: Tudor Chirila Jr. In this episode of Body Bags, forensics expert Joseph Scott Morgan and Jackie Howard discuss the lack of evidence the crime scene, why Nancy's roommate thought this might have been a suicide, distinguishing between stab wounds, how phenotyping lead to the breakthrough in this case, and much more.    Subscribe to Body Bags with Joseph Scott Morgan : Apple Podcasts Spotify iHeart   Show Notes: 0:00 - Intro 2:37 - Background and overview of case 4:15 - How do you investigate a case once it's gone cold? 7:20 - Stab wounds 11:30 - No evidence of foul play at the crime scene 15:45 - The roommate and thinking Nancy had comitted suicide  18:40 - Water running in the bathroom 21:00 - How do you distinguish between wounds? 24:40 - The salesman as suspects 26:35 - Bathrooms as a popular crime scene 30:05 - Blood testing process 35:35 - How do you preserve evidence? 41:17 - What is Phenotyping and how did it help the investigation? 47:55 - Genealogy and a son 49:20 - The suspect is found 50:43 - Wrap up See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.17.512628v1?rss=1 Authors: Arab, T., Huang, Y., Nagaraj, R., Gizzie, E., Redding-Ochoa, J., Troncoso, J. C., Pletnikova, O., Boronina, T., Cole, R. N., Mahairaki, V., Routenberg, D. A., Witwer, K. W. Abstract: Extracellular vesicles (EVs) are produced by all cell types and are found in all tissues and biofluids. EV proteins, nucleic acids, and lipids are a "nano-snapshot" of the parent cell that may be used for novel diagnostics of various diseases, including neurodegenerative disorders. Currently, diagnosis of the most common neurodegenerative movement disorder, Parkinsons disease (PD), relies on manifestations of late-stage progression, which may furthermore associate with other neurodegenerative diseases such as progressive supranuclear palsy (PSP). Here, we profiled surface markers and other protein contents of brain-derived extracellular vesicles (bd-EVs) from PD (n= 24), PSP (n=25) and control (n=24). bdEVs displayed tetraspanins and certain microglia, astrocyte, and neuron markers, while quantitative proteomics revealed enrichment of several proteins in PD vs. control and/or PSP, including clathrin heavy chain 1 and 14-3-3 protein gamma. This characterization of EVs in the source tissue provides insights into local dynamics as well as biomarker candidates for investigation in peripheral fluids. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr Sumanta Talukdar, Founder & CEO of Gardin, takes us through the importance of digital phenotyping in agriculture, his views on the sector and what he thinks the future holds for food production. Hosted on Acast. See acast.com/privacy for more information.

On January 7th, 1972, Nancy Anderson, 19, is found dead in her Waikiki apartment with over 60 stab wounds. The case goes cold for fifty years until new DNA technology and detective work leads to the arrest of a suspect: Tudor Chirila Jr. In this episode of Body Bags, forensics expert Joseph Scott Morgan and Jackie Howard discuss the lack of evidence the crime scene, why Nancy's roommate thought this might have been a suicide, distinguishing between stab wounds, how phenotyping lead to the breakthrough in this case, and much more.    Show Notes: 0:00 - Intro 2:37 - Background and overview of case 4:15 - How do you investigate a case once it's gone cold? 7:20 - Stab wounds 11:30 - No evidence of foul play at the crime scene 15:45 - The roommate and thinking Nancy had comitted suicide  18:40 - Water running in the bathroom 21:00 - How do you distinguish between wounds? 24:40 - The salesman as suspects 26:35 - Bathrooms as a popular crime scene 30:05 - Blood testing process 35:35 - How do you preserve evidence? 41:17 - What is Phenotyping and how did it help the investigation? 47:55 - Genealogy and a son 49:20 - The suspect is found 50:43 - Wrap up See omnystudio.com/listener for privacy information.

Here are the relevant links for this episode:Red tape awardNEWS RELEASE: City wins 2022 Municipal Excellence Award for Red Tape Reduction UAlberta ventilation dataUniversity of Alberta releases building-specific ventilation dataLearning city NEWS RELEASE: Edmonton secures place as Canada's first UNESCO Global Network of Learning Cities member Mayor Amarjeet Sohi's tweet Guest: Bashir Mohamed @BashirMohamed Edmonton SRO Research Project DNA phenotyping NEWS RELEASE: Police use DNA phenotyping in unsolved sexual assault EPS Statement on DNA Phenotyping Edmonton police use DNA phenotyping as 'last resort' in hopes of identifying sexual assault suspect Ubaka Ogbogu's tweet Opinion: Edmonton police wrong to release DNA phenotyping mugshot of a Black man Single-use reduction bylaw NEWS RELEASE: City council passes bylaw to significantly reduce waste Edmonton finalizes plastic bag, disposable food container bylaw Edmonton restaurants grapple with proposed ban on single-use items Rec centre naming rights Edmonton councillors vote to sell naming rights of Clareview Recreation Centre Clareview Rec Centre to be renamed Jumpstart Community Recreation Centre EPS jurisdictional scan Edmonton police funding debate dominated by conflict of interest concerns Per Capita Police Funding Police funding increases could be locked in before budget talks EPS funding formula Councillors consider new funding formula for Edmonton Police Service Mack's tweet thread Speaking Municipally is a proud member of the Alberta Podcast Network: locally grown, community supported.This week we talked about The Well Endowed Podcast from the Edmonton Community Foundation, which explores the impact of passionate people who are working to make Edmonton a strong, vibrant city to live in. We also highlighted Park Power, your friendly, local utilities provider in Alberta. Offering Internet, Electricity, and Natural Gas with low rates, awesome service, and profit-sharing with local charities.Speaking Municipally is produced by Taproot Edmonton, a source of curiosity-driven original stories, curated newsletters on various topics, and locally focused podcasts, all in the service of informing Edmontonians about what is going on in their community. Sign up to get The Pulse, our weekday news briefing. It's free! ★ Support this podcast ★

Alastair and Praveen are joined by the renowned Todd Villines to discuss the evolving role of cardiac CT in identifying cardiovascular disease phenotypes. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.24.505107v1?rss=1 Authors: Bauza, M., Krstulovic, M., Krupic, J. Abstract: Spatial working memory and image recognition tests are commonly used to facilitate the diagnosis of hippocampal-related neurological disorders such as Alzheimers disease due to their relatively high specificity and sensitivity to damage to the medial temporal lobes compared to standard commonly used clinical tests. Pathological changes in Alzheimers disease start years before the formal diagnosis is made, partially due to testing too late. To address this challenge, we developed a novel digital platform, hAge (healthy Age), which integrates double spatial alternation, image recognition and visuospatial tasks for frequent remote unsupervised assessment of spatial and non-spatial working memory. 191 healthy adults (67% females, 18-81 years old) participated in the study. In line with findings using standard laboratory tests, we showed that performance on the spatial alternation task negatively correlated with inter-trial periods and performance levels on image recognition and visuospatial tasks can be controlled by varying image similarity. Importantly, we demonstrated that frequent engagement with the double spatial alternation task leads to a strong practice effect, previously identified as a potential measure of cognitive decline in MCI patients. Finally, we discuss how lifestyle and motivation confounds may present a serious challenge for cognitive assessment in real-world uncontrolled environments. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Joseph is a Professor of Dermatology at Harvard University. He is also the Editor-in-Chief of npj Digital Medicine one of the most relevant academic journals for publications at the intersection of innovation and digital health. Beyond that Joseph has been working and adivsing different healthtech ventures over the past years.   Together with Joseph we dove into the status-quo for the most relevant digital health applications and discussed opportunities and challenges. 

A new study highlights areas of compatibility and strategies to move towards better communication and collaboration. You can read this post online at https://botany.one/2022/06/connecting-plant-phenotyping-and-modelling-communities/ You can read the original research at https://doi.org/10.1093/insilicoplants/diac005

Commentary by Dr. Valentin Fuster

Not all patients with obstructive sleep apnea experience daytime sleepiness. In this episode of Talking Sleep, we talk with researcher and clinician Dr. Allan Pack about phenotyping OSA patients to understand the differences in patient clusters based on physiology, symptoms, clinical presentations, and other factors. Phenotyping patients ultimately will allow clinicians to offer more personalized treatment.

Can high-resolution imaging and computational processing be used to quantify variation in photomorphogenesis among Arabidopsis seedlings? Read the article at https://www.botany.one/2021//12/computer-vision-for-phenotyping-of-photomorphogenesis/ Read the original research at https://doi.org/10.1093/aobpla/plab063

Nick Jikomes talks to Dr. Nathan Price, who has a PhD is in bioengineering and has been faculty at the University of Washington and the Institute of Systems Biology. He was also CEO of a health intelligence startup called Onegevity, which recently merged with Thorne HealthTech, which he is Chief Science Officer of. Nathan and Nick discussed various topics in the realm of personalized medicine, digital phenotyping and systems biology, including things like metabolism & blood sugar monitoring, the microbiome & diet, aging & longevity, and more. They talked about the basic biology of these things, as well as different emerging technologies related to health monitoring.USEFUL LINKSSign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/]Download the podcast & follow Nick at his website[https://www.nickjikomes.com]Buy books by M&M guests[https://linktr.ee/mindandmatter_books]Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)[https://athleticgreens.com/partner/d3...]Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]Follow & Support Nick's work[https://linktr.ee/trikomes]Learn more about our podcast sponsor, Dosist[https://dosist.com/]Support the show (https://www.patreon.com/nickjikomes)

In this episode, Joe and Kyle interview CEO & Co-founder of Nue Life, Juan Pablo Cappello. He discusses his entrepreneurial past, the psychedelic gold rush, and how Nue Life will use digital phenotyping to personalize health. www.psychedelicstoday.com