Podcast appearances and mentions of may jun

Popular during the early years of adhesive dentistry, chemical-cure dentin bonding systems have since become less common with the rise of light-curing, but they still serve a purpose when restoring the pulp chambers of endodontically treated teeth. In this episode Dr. David Alleman discusses the polymerization dynamics of chemical-cure and light-cure adhesives and how that impacts their effectiveness in different aspects of a successful adhesive restoration.Article referenced in this episode:Toshifumi Kuroe, Kana Tachibana, Yukinori Tanino, Noriyuki Satoh, Noboru Ohata, Hidehiko Sano, Nobuo Inoue, Angelo A Caputo, Contraction stress of composite resin build-up procedures for pulpless molars. J Adhes Dent. 2003 Spring;5(1):71-7.S Deliperi, D Alleman, D Rudo. Stress-reduced Direct Composites for the Restoration of Structurally Compromised Teeth: Fiber Design According to the "Wallpapering". Oper Dent. 2017 May/Jun;42(3):233-243. doi: 10.2341/15-289-T. TechniqueAt 12:35 Dr. Alleman creates illustrations to demonstrate air inhibition. To view this video, watch the episode on YouTube https://youtu.be/Y1xHishKlOo or search for Six Lessons Approach Podcast.Send us a textLearn more about Dr. Alleman's work at training programs at allemancenter.com/events. Upcoming training programs April 25-26: SLA In-Person Workshop May 12 Biomimetic Mastership Instagram @david.alleman.dds@davey_alleman_dmd@allemancenter.comYouTube@allemancenter

A new year and a new beginning. Special guest co-host Pedro Mendes joins Dr. Chris Labos to answer a viewer question about menopause. Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Email us your questions at thebodyofevidence@gmail.com. Assistant researcher: Aigul Zaripova, MD Editor: Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause- cancer Obviously, I'm not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Geographic variability of menopausal symptoms 1) Nappi RE et al. Global cross-sectional survey of women with vasomotor symptoms associated with menopause: prevalence and quality of life burden. Menopause. 2021 May 24;28(8):875-882. doi: 10.1097/GME.0000000000001793. 2) Nappi RE, et al. Prevalence and quality-of-life burden of vasomotor symptoms associated with menopause: A European cross-sectional survey. Maturitas. 2023 Jan;167:66-74. doi: 10.1016/j.maturitas.2022.09.006. What's the normal duration of symptoms 3) Avis NE, et al. Study of Women's Health Across the Nation. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015 Apr;175(4):531-9. doi: 10.1001/jamainternmed.2014.8063. The Women's Health Initiative (WHI) studies Rossouw JE et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33. doi: 10.1001/jama.288.3.321. Anderson GL et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004 Apr 14;291(14):1701-12. doi: 10.1001/jama.291.14.1701. Decline in HRT after WHI studies Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet Gynecol. 2012 Sep;120(3):595-603. doi: 10.1097/AOG.0b013e318265df42. Danish Osteoporosis Prevention Study Schierbeck LL metal. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409. doi: 10.1136/bmj.e6409. Kronos Early Estrogen Prevention Study (KEEPS) Harman SM, et al. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60. doi: 10.7326/M14-0353. Kronos Early Estrogen Prevention Study (KEEPS) Hodis HN et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241. Stopping hormonal therapy Berman RS et al. Risk factors associated with women's compliance with estrogen replacement therapy. J Womens Health. 1997 Apr;6(2):219-26. doi: 10.1089/jwh.1997.6.219. Grady D, Sawaya GF. Discontinuation of postmenopausal hormone therapy. Am J Med. 2005 Dec 19;118 Suppl 12B:163-5. doi: 10.1016/j.amjmed.2005.09.051. Tapering vs. abrupt stop or hormonal therapy Haimov-Kochman R et al. Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study. Menopause. 2006 May-Jun;13(3):370-6. doi: 10.1097/01.gme.0000186663.36211.c0. PMID: 16735933.

Dr. Trina Augustin, assistant professor of both anesthesiology and perioperative medicine as well as emergency medicine takes us on a deep dive into the care of persons with aortic stenosis. In this chapter, Alex and Venk learn about how to use ultrasound to diagnose AS, the keys to resuscitation, the pathophysiology of this condition, as well as the value of consultative services and the potential interventions that they may unlock for these patients. Kickoff season 4 with this in depth reminder that sometimes the heart has many hidden perils beyond ACS.  CONTACTS X - @AlwaysOnEM; @VenkBellamkonda YouTube - @AlwaysOnEM; @VenkBellamkonda Instagram – @AlwaysOnEM; @Venk_like_vancomycin; @ASFinch; @KatrinaJoyAugustin Email - AlwaysOnEM@gmail.com REFERENCES & LINKS Lichtenstein DA, Meziere GA. Relevance of Lung Ultrasound in the Diagnosis of Acute Respiratory Failure. Chest 2008; 134:117-125 Walsh MH, Smyth LM, Desy JR, Fischer EA, Goffi A, Li N, Lee M, St-Pierre J, Ma IWY. Lung Ultrasound: A Comparison of image interpretation accuracy between curvillinear and phased array transducers. Australia J Ultrasound Med, 26:150-156 Alzahrani H, Woo MY, Johnson C, Pageau P, Millington S, Thiruganasambandamoorthy V. Can severe aortic stenosis be identified by emergency physicians when interpreting a simplified two-view echocardiogram obtained by trained echocardiographers? Crit Ultrasound J. 2015 Apr 18;7:5. doi: 10.1186/s13089-015-0022-8. PMID: 25932319; PMCID: PMC4409610. Furukawa A, Abe Y, Morizane A, Miyaji T, Hosogi S, Ito H. Simple echocardiographic scoring in screening aortic stenosis with focused cardiac ultrasonography in the emergency department. J Cardiol. 2021 Jun;77(6):613-619. doi: 10.1016/j.jjcc.2020.12.006. Epub 2020 Dec 29. PMID: 33386216. Lin J, Drapkin J, Likourezos A, Giakoumatos E, Schachter M, Sarkis JP, Moskovits M, Haines L, Dickman E. Emergency physician bedside echocardiographic identification of left ventricular diastolic dysfunction. American Journal of Emergency medicine  Ehrman RR, Russell FM, Ansari AH, Margeta B, Clary JM, Christian E, Cosby KS, Bailitz J. Can emergency physicians diagnose and correctly classify diastolic dysfunction using bedside echocardiography? Am J Emerg Med. 2015 Sep;33(9):1178-83. doi: 10.1016/j.ajem.2015.05.013. Epub 2015 May 21. PMID: 26058890.2021;44:20-25 Del Rios M, Colla J, Kotini-Shah P, Briller J, Gerber B, Prendergast H. Emergency physician use of tissue Doppler bedside echocardiography in detecting diastolic dysfunction: an exploratory study. Crit Ultrasound J. 2018 Jan 25;10(1):4. doi: 10.1186/s13089-018-0084-5. PMID: 29372430; PMCID: PMC5785451. Thiele H, Zeymer U, Neumann FJ, Ferenc M, Olbrich HG, Hausleiter J, de Waha A, Richardt G, Hennersdorf M, Empen K, Fuernau G, Desch S, Eitel I, Hambrecht R, Lauer B, Böhm M, Ebelt H, Schneider S, Werdan K, Schuler G; Intraaortic Balloon Pump in cardiogenic shock II (IABP-SHOCK II) trial investigators. Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial. Lancet. 2013 Nov 16;382(9905):1638-45. doi: 10.1016/S0140-6736(13)61783-3. Epub 2013 Sep 3. PMID: 24011548. Aksoy O, Yousefzai R, Singh D, Agarwal S, O'Brien B, Griffin BP, Kapadia SR, Tuzcu ME, Penn MS, Nissen SE, Menon V. Cardiogenic shock in the setting of severe aortic stenosis: role of intra-aortic balloon pump support. Heart. 2011 May;97(10):838-43. doi: 10.1136/hrt.2010.206367. Epub 2010 Oct 20. PMID: 20962337. Karatolios K, Chatzis G, Luesebrink U, Markus B, Ahrens H, Tousoulis D, Schieffer B. Impella support following emergency percutaneous balloon aortic valvuloplasty in patients with severe aortic valve stenosis and cardiogenic shock. Hellenic J Cardiol. 2019 May-Jun;60(3):178-181. doi: 10.1016/j.hjc.2018.02.008. Epub 2018 Mar 21. PMID: 29571667. Gottlieb M, Long B, Koyfman A. Evaluation and Management of Aortic Stenosis for the Emergency Clinician: An Evidence-Based Review of the Literature. J Emerg Med. 2018 Jul;55(1):34-41. doi: 10.1016/j.jemermed.2018.01.026. Epub 2018 Mar 7. PMID: 29525246.  

Ever wondered if a plant could be both a herbal remedy and a controversial subject in addiction medicine? Join us as we uncover the multifaceted nature of Kratom with Dr. Sonia Del Tredici and Dr. John Keenan from the Addiction Medicine Journal Club podcast for a journal club style episode on Kratom. Together, we explore Kratom's historical uses for pain relief and fatigue management and its growing popularity as an aid in opioid withdrawal. This episode promises to give you a thorough understanding of its pharmacological effects, including interactions with opioid receptors and anti-inflammatory benefits.Our conversation shifts to the intriguing trends in Kratom usage across the United States. We dissect three recent studies on Kratom, highlighting Kratom's allure as a perceived safer option for managing anxiety, depression, and pain. Despite its benefits, we don't shy away from discussing its potential for addiction and the demographic reach of its users. This episode challenges listeners to consider whether the overlap between Kratom users and those with other substance use disorders is surprising or expected, urging healthcare providers to adopt open-ended dialogues to address patient needs effectively.In a deep dive into Kratom Use Disorder, our discussion includes a fascinating case series study examining the use of buprenorphine for treatment. We highlight the study's findings on withdrawal management and Kratom metabolite reduction, exploring the effectiveness of buprenorphine in stabilizing patients. With a significant portion of patients remaining in follow-up care, we ponder the subjective effects of using Kratom alongside buprenorphine. Tune in to grasp the complexities of Kratom use and the importance of education and ongoing research, as we prepare for an upcoming interview with an industry professional to continue this enlightening series.Our episode reviews three studies on Kratom to facilitate our discussion. Here are those studies:Smith KE, Dunn KE, Rogers JM, Grundmann O, McCurdy CR, Garcia-Romeu A, Schriefer D, Swogger MT, Epstein DH. Kratom use as more than a "self-treatment". Am J Drug Alcohol Abuse. 2022 Nov 2;48(6):684-694.  Hill K, Grundmann O, Smith KE, Stanciu CN. Prevalence of Kratom Use Disorder Among Kratom Consumers. J Addict Med. 2024 May-Jun 01;18(3):306-312. Broyan, V. R., Brar, J. K., Allgaier, Student, T., & Allgaier, J. T. (2022). Long-term buprenorphine treatment for kratom use disorder: A case series. Substance Abuse, 43(1), 763–766. To contact Dr. Grover: ammadeeasy@fastmail.com

In episode 50 we discuss 3 articles about kratom. We are again joined by our friend Dr. Casey Grover from the Addiction Medicine Made Easy Podcast.    Smith KE, Dunn KE, Rogers JM, Grundmann O, McCurdy CR, Garcia-Romeu A, Schriefer D, Swogger MT, Epstein DH. Kratom use as more than a "self-treatment". Am J Drug Alcohol Abuse. 2022 Nov 2;48(6):684-694.     Hill K, Grundmann O, Smith KE, Stanciu CN. Prevalence of Kratom Use Disorder Among Kratom Consumers. J Addict Med. 2024 May-Jun 01;18(3):306-312.    Broyan, V. R., Brar, J. K., Allgaier, Student, T., & Allgaier, J. T. (2022). Long-term buprenorphine treatment for kratom use disorder: A case series. Substance Abuse, 43(1), 763–766.   ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno  Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---  This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.     The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.  Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  YouTube: addictionmedicinejournalclub   Twitter/X: @AddictionMedJC    Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.   

In this Complex Care Journal Club podcast episode, Dr. Renee Turchi discusses an intervention study to improve emergency preparedness for families with children and youth with special health care needs. She describes the multiple community partners involved in intervention development, key insights gained while conducting the study, and next steps from this work. SPEAKER Renee M. Turchi, MD, MPH, FAAP Professor and Chair of Pediatrics, Pediatrician in Chief St. Christopher's Hospital for Children HOST Emily Goodwin, MD Clinical Associate Professor of Pediatrics, University of Missouri Kansas City School of Medicine Pediatrician, General Academic Pediatrics Beacon Program, Children's Mercy Kansas City DATE Initial publication date: October 7, 2024. JOURNAL ARTICLE Griffin JS, Hipper TJ, Chernak E, Berhane Z, Davis RK, Popek L, Kurapati P, Kim J, Turchi RM. A Virtual Home Preparedness Intervention Centered on Children and Youth With Special Health Care Needs. Acad Pediatr. 2024 Jun 10:S1876-2859(24)00167-0. doi: 10.1016/j.acap.2024.06.002. Epub ahead of print. PMID: 38866363. https://www.academicpedsjnl.net/article/S1876-2859(24)00167-0/fulltext OTHER REFERENCES Hipper TJ, Davis R, Massey PM, Turchi RM, Lubell KM, Pechta LE, Rose DA, Wolkin A, Briseño L, Franks JL, Chernak E. The Disaster Information Needs of Families of Children with Special Healthcare Needs: A Scoping Review. Health Secur. 2018 May/Jun;16(3):178-192. doi: 10.1089/hs.2018.0007. Epub 2018 Jun 8. PMID: 29883200; PMCID: PMC11015856. https://pubmed.ncbi.nlm.nih.gov/29883200/ TRANSCRIPT https://op-docebo-images.s3.amazonaws.com/Transcripts/Preparing+for+Emergencies+Planning+and+Partnerships+with+Families_Turchi_100824.pdf Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Turchi RM, Goodwin EJ. Preparing for Emergencies: Planning and Partnerships with Families. 10/2024. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/preparing-for-emergencies-planning-and-partnerships-with-families.

Pour accéder à l'intégralité de ce podcast et écouter chaque semaine un nouvel épisode du Quart d'Heure Véto, c'est très simple, il vous suffit de vous abonner en cliquant sur ce lien : https://m.audiomeans.fr/s/S-yUNSBZSR Notes et références Article : Craven A, Todd-Donato A, Stokol T, Liepman R, Glasberg I, Wilkins P, Luethy D, Wong D, Schoster A, van den Brom-Spierenburg AJ, Tomlinson JE. Clinical findings and outcome predictors for multinodular pulmonary fibrosis in horses: 46 cases (2009-2019). J Vet Intern Med. 2024 May-Jun;38(3):1842-1857. doi: 10.1111/jvim.17084. Epub 2024 Apr 15. PMID: 38619130; PMCID: PMC11099712. Retrouvez toute la synthèse sur la fiche podcast juste ici : https://audmns.com/iPQLQWQ Pour nous suivre : 1. Abonnez-vous à notre chaine pour profiter de l'intégralité des épisodes : Le Quart d'Heure Véto : décrypte et résume en moins de 15 min un article de biblio véto - Sur abonnement uniquement Le Véto du Mois : Partagez le temps d'une interview l'expérience de vétérinaires emblématiques de notre milieu, des rencontres conviviales, comme si nous étions dans votre salon au coin du feu. Podcasts bonus au fil des inspirations... 2. Le Scope Nous partageons avec vous nos dernières découvertes, inspirations, pistes de réflexion, nouveautés… À découvrir et utiliser dès maintenant, TOUT DE SUITE, dans votre quotidien de vétérinaire, de manager, de vie personnelle, de chef d'entreprise… Et tout cela en moins de 5 minutes top chrono un à 2 mardis par mois ! Je souhaite recevoir mon Scope : https://vetmasterclass.com/lescope/ 3. Contactez-nous, suivez-nous et donnez nous votre avis ! Des sujets que vous souhaiteriez approfondir, des références à partager, ou nous faire part de vos feed-backs : Abonnez-vous à notre chaine, donnez nous des étoiles, un commentaire et partagez autour de vous ! Sur notre site : https://vetmasterclass.com/ Sur Facebook : https://www.facebook.com/VmHorse Sur Instagram : https://www.instagram.com/vetmasterclass/ Sur YouTube : https://www.youtube.com/channel/UC18ovcWk9e-mFiTL34OQ03g Sur Linkedin : https://www.linkedin.com/company/vetmasterclass-horse/about/ Belle journée à tous, Et continuez à vivre votre métier avec Passion !

Un nouvel épisode du Pharmascope est disponible et on s'attaque cette fois au trouble d'usage d'alcool. Dans cette première partie, Nicolas, Isabelle et une nouvelle invitée discutent du dépistage et de l'évaluation de cette maladie sous diagnostiquée, en plus de réviser la prise en charge du sevrage alcoolique. Les objectifs pour cet épisode sont: Procéder au dépistage du trouble d'usage d'alcool Diagnostiquer un trouble d'usage d'alcool Discuter des bénéfices et des désavantages associés aux principaux traitements pharmacologiques du sevrage alcoolique Ressources pertinentes en lien avec l'épisode Lignes directrices canadiennes récentes en trouble d'usage d'alcoolWood E, Bright J, Hsu K, et coll. Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder. CMAJ. 2023 Oct 16;195(40):E1364-E1379. Repères canadiens sur l'alcool et la santé : rapport final. Centre canadien sur les dépendances et l'usage de substances. 2023 Guide canadien sur les risques associés à l'usage d'alcoolCoalition canadienne pour la santé mentale des personnes pagées. Lignes directrices sur le trouble lié à l'utilisation de l'alcool chez les personnes âgées. 2023. Guide de l'INESSS sur la prise en charge du trouble d'utilisation d'alcoolINESSS. Sevrage d'alcool et prévention des rechutes. 2021. US Preventive Services Task Force; Curry SJ, Krist AH, Owens DK, et coll. Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Nov 13;320(18):1899-1909. Mitchell AJ, Bird V, Rizzo M, et coll. Accuracy of one or two simple questions to identify alcohol-use disorder in primary care: a meta-analysis. Br J Gen Pract. 2014 Jul;64(624):e408-18. Bush K, Kivlahan DR, McDonell MB, et coll. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med. 1998 Sep 14;158(16):1789-95. Maldonado JR, Sher Y, Das S, et coll. Prospective Validation Study of the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) in Medically Ill Inpatients: A New Scale for the Prediction of Complicated Alcohol Withdrawal Syndrome. Alcohol Alcohol. 2015 Sep;50(5):509-18. Kaner EF, Beyer FR, Muirhead C, et coll. Effectiveness of brief alcohol interventions in primary care populations. Cochrane Database Syst Rev. 2018 Feb 24;2(2):CD004148. Amato L, Minozzi S, Vecchi S, Davoli M. Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev. 2010 Mar 17;(3):CD005063. Daeppen JB, Gache P, Landry U, et coll. Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial. Arch Intern Med. 2002 May 27;162(10):1117-21. Elholm B, Larsen K, Hornnes N, Zierau F, Becker U. Alcohol withdrawal syndrome: symptom-triggered versus fixed-schedule treatment in an outpatient setting. Alcohol Alcohol. 2011 May-Jun;46(3):318-23. Minozzi S, Amato L, Vecchi S, Davoli M. Anticonvulsants for alcohol withdrawal. Cochrane Database Syst Rev. 2010 Mar 17;(3):CD005064. Airagnes G, Valter R, Ducoutumany G, Vansteene C, Trabut JB, Gorwood P, Dubertret C, Matta J, Charles-Nelson A, Limosin F. Magnesium in the treatment of alcohol withdrawal syndrome: a multicenter randomized controlled trial. Alcohol Alcohol. 2023 May 9;58(3):329-335.

There continues to be great confusion regarding the impact of hormone therapy on the breast. And despite the known benefits of hormone therapy, and reassuring data regarding the impact of hormone therapy on breast cancer, most clinicians are still reluctant to prescribe it, and most women are reluctant to take it. Even more so if a woman is high risk for breast cancer or has a breast cancer diagnosis.  In this episode, I am joined by Dr. Corinne Menn, a board-certified Ob GYN and menopause expert who herself had a breast cancer diagnosis when she was in her 20s. We will be reviewing the latest research on the impact of estrogen on the breast in several different scenarios.  PREGNANCY post breast cancer Women who have a BREAST CANCER diagnosis  Women with a FAMILY HISTORY of breast cancer Women with a BRCA MUTATION after prophylactic ovary removal The approach to therapy for women with a NEW BREAST CANCER DIAGNOSIS The use of local vaginal estrogen in women with a breast cancer diagnosis that are taking TAMOXIFEN or using an AROMOTASE INHIBITOR If a LOCAL VAGINAL ESTROGEN needs to  be used at the lowest dose What to do if your DOCTOR NOT WILLING to prescribe local or systemic estrogen (list of articles to share is below)  If a woman with a breast cancer diagnosis can use TESTOSTERONE for libido and other possible benefits Dr. Corrine Menn https://drmenn.com/ @drmennobgyn For more information: Episode 124 All Hormones Are Not Created Equal with Dr. James Simon Episode 65- The Dilemma of Menopause and Breast Cancer Episode 31 The TRUTH About Hormone Therapy: Does it CAUSE or Does it PREVENT Breast Cancer? Episode 28: The BEST approach for BREAST Cancer Screening and Risk Reduction with Dr. Lisa Larkin Dr. Streicher's Inside Information podcast is not intended to replace medical advice and should be used to supplement, not replace, care by your personal health care clinician. Dr. Streicher disclaims liability for any medical outcomes that may occur because of applying methods suggested or discussed in this podcast. Scientific Articles  Hormone Therapy and Risk of Breast Cancer Bluming AZ, Hodis HN, Langer RD. 'Tis but a scratch: a critical review of the Women's Health Initiative evidence associating menopausal hormone therapy with the risk of breast cancer. Menopause. 2023 Dec 1;30(12):1241-1245.  Bluming AZ. Introduction: Estrogen Reconsidered: Exploring the Evidence for Estrogen's Benefits and Risks. Cancer J. 2022 May-Jun 01;28(3):157-162.  Hodis HN, Sarrel PM. Menopausal hormone therapy and breast cancer: what is the evidence from randomized trials? Climacteric 2018;21:521–8. Levy B, Simon JA. A Contemporary View of Menopausal Hormone Therapy. Obstet Gynecol. 2024 Mar 14.  Chlebowski RT, Aragaki AK, Pan K, Mortimer JE, Johnson KC, Wactawski-Wende J, LeBoff MS, Lavasani S, Lane D, Nelson RA, Manson JE. Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis. Breast Cancer Res Treat. 2024 Apr 23. doi: 10.1007/s10549-024-07307-9.  Pan K, Lavasani S, Aragaki AK, Chlebowski RT. Estrogen therapy and breast cancer in randomized clinical trials: a narrative review. Menopause. 2022 Sep 1;29(9):1086-1092.  Use of Hormone Therapy in Women with a Breast Cancer Diagnosis Bluming A. Hormone replacement therapy after breast cancer: it is time. Cancer J 2022;28:183–90.  Bluming AZ. Safety of systemic hormone replacement therapy in breast cancer survivors. Breast Cancer Res Treat. 2022 Feb;191(3):685-686. doi: 10.1007/s10549-021-06479-y.  Fahlén M, Fornander T, Johansson H, Johansson U, Rutqvist LE, Wilking N, von Schoultz E. Hormone replacement therapy after breast cancer: 10 year follow up of the Stockholm randomised trial. Eur J Cancer. 2013 Jan;49(1):52-9. Mikkola TS, Savolainen-Peltonen H, Tuomikoski P, Hoti F, Vattulainen P, Gissler M, et al. Reduced risk of breast cancer mortality in women using postmenopausal hormone therapy: a Finnish nationwide comparative study. Menopause 2016;23:1199–203 Hormone Therapy in Women with BRCA Mutation Kotsopoulos J, Gronwald J, Karlan BY, Huzarski T, Tung N, Moller P, Armel S, Lynch HT, Senter L, Eisen A, Singer CF, Foulkes WD, Jacobson MR, Sun P, Lubinski J, Narod SA; Hereditary Breast Cancer Clinical Study Group. Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers. JAMA Oncol. 2018 Aug 1;4(8):1059-1065.. Lauren Streicher, MD is a clinical professor of obstetrics and gynecology at Northwestern University's Feinberg School of Medicine, and the founding medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause. She is a certified menopause practitioner of the North American Menopause Society.  Sign up to receive DR. STREICHER'S FREE NEWSLETTER Dr. Streicher is the medical correspondent for Chicago's top-rated news program, the WGN Morning News, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr. Radio, Nightline, Fox and Friends, The Steve Harvey Show, CBS This Morning, ABC News Now, NBCNightlyNews,20/20, and World News Tonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine, and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.  Subscribe and Follow Dr. Streicher on  DrStreicher.com Instagram @DrStreich Facebook  @DrStreicher YouTube  DrStreicherTV Books by Lauren Streicher, MD  Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Sex Rx- Hormones, Health, and Your Best Sex Ever The Essential Guide to Hysterectomy

The Jazz Session No.365 from RaidersBroadcast.com as aired in May-Jun 2024, featuring the amazing modern jazz album “Empire Central” from Snarky Puppy. TRACK LISTING: Sonya - Miles Davis; A Shade of Jade - Nubya Garcia; Too Busy - Ken Colyer's Jazzmen; Bessie Couldn't Help It - Billy Cotton & His Band; Bet - Snarky Puppy; Trinity - Snarky Puppy; Lover Man [at Ronnie Scott's] - Stan Tracey Quartet; Perdido - Dizzy Gillespie & His Orchestra; Memphis Underground - Herbie Mann; It Must Be a Camel - Frank Zappa; El Emadi - Yazz Ahmed; Islands - Steps Ahead; Do What You Gotta Do - Nina Simone; Viola - Sergio Mendes & Brasil '66; Pineapple - Snarky Puppy; RL's - Snarky Puppy; Did You Get It? - The New Gary Burton Quartet; The Impetus (To Be and Do Better) - Joel Ross; Through Space Our Minds Can Still Touch - Playtime; Mombasa - Fat-Suit.

"Nanogod" was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003 visit www.darkmattermagazine.shop.  CREDITS Written by Larry Hodges Performed by Nick Robertson Sound Design by Alli Nova Produced by Phil McLaughlin   We have three titles now available in our audiobook catalogue!  Dark Matter Presents Haunted Reels: Stories from the Minds of Professional Filmmakers curated by David Lawson Jr., Rootwork by Tracy Cross, and Linghun by Ai Jiang are just the beginning of our growing Audible library of carefully edited and lightly sound designed audiobooks.  Join us for the best and darkest of sci-fi and horror, and we'll see you in two weeks!

Nelson y Matías comentan la falacia de la tasa basal, ejemplificada en la dyskinesis escapular. Artículos citados J Orthop Sports Phys Ther . 2017 Aug;47(8):530-537. doi: 10.2519/jospt.2017.7268. Epub 2017 Jul 6. Observational Scapular Dyskinesis: Known-Groups Validity in Patients With and Without Shoulder Pain Hillary A Plummer, Jonathan C Sum, Federico Pozzi, Rini Varghese, Lori A Michener PMID: 28683230 DOI: 10.2519/jospt.2017.7268 Orthop J Sports Med . 2016 Feb 17;4(2):2325967115627608. doi: 10.1177/2325967115627608. eCollection 2016 Feb. Prevalence of Scapular Dyskinesis in Overhead and Nonoverhead Athletes: A Systematic Review Matthew B Burn 1, Patrick C McCulloch 1, David M Lintner 1, Shari R Liberman 1, Joshua D Harris 1 Affiliations expand PMID: 26962539 PMCID: PMC4765819 DOI: 10.1177/2325967115627608  Braz J Phys Ther . 2014 May-Jun;18(3):282-9. doi: 10.1590/bjpt-rbf.2014.0025. Can clinical observation differentiate individuals with and without scapular dyskinesis? [Article in English, Portuguese] Newton Y Miachiro 1, Paula M F Camarini 1, Helga T Tucci 2, Kevin J McQuade 3, Anamaria S Oliveira 1 Affiliations expand PMID: 25003282 PMCID: PMC4183499 DOI: 10.1590/bjpt-rbf.2014.0025  Arthroscopy . 2009 Nov;25(11):1240-8. doi: 10.1016/j.arthro.2009.06.007. Evaluation of clinical assessment methods for scapular dyskinesis Tim L Uhl 1, W Ben Kibler, Ben Gecewich, Brady L Tripp Affiliations expand PMID: 19896045 DOI: 10.1016/j.arthro.2009.06.007 Int J Sports Phys Ther . 2023 Jun 1;V18(3):558-576. doi: 10.26603/001c.74388. eCollection 2023. Is it Time to Normalize Scapular Dyskinesis? The Incidence of Scapular Dyskinesis in Those With and Without Symptoms: a Systematic Review of the Literature Paul A Salamh, William J Hanney, Trey Boles, Daniel Holmes, Alex McMillan, Austin Wagner, Morey J Kolber PMID: 37425102 PMCID: PMC10324350 DOI: 10.26603/001c.74388  Phys Ther . 2016 Aug;96(8):1162-9. doi: 10.2522/ptj.20140230. Epub 2016 Feb 4. Critical and Theoretical Perspective on Scapular Stabilization: What Does It Really Mean, and Are We on the Right Track? Kevin J McQuade 1, John Borstad 2, Anamaria Siriani de Oliveira 3 Affiliations expand PMID: 26847012 DOI: 10.2522/ptj.20140230 Arch Phys Med Rehabil . 2017 Oct;98(10):1915-1923.e3. doi: 10.1016/j.apmr.2017.05.023. Epub 2017 Jun 24. Effects of Scapular Stabilization Exercise Training on Scapular Kinematics, Disability, and Pain in Subacromial Impingement: A Randomized Controlled Trial Elif Turgut 1, Irem Duzgun 2, Gul Baltaci 3 Affiliations expand PMID: 28652066 DOI: 10.1016/j.apmr.2017.05.023

Mamileiros e mamiletes, o que inspira o Mamilos Cultura de hoje é o livro A Tirania do Mérito, de Michael J. Sandel. As democracias liberais estão em risco. E, de acordo com o filósofo Michael J. Sandel, o princípio do mérito, um de seus pilares básicos, é o responsável por esse cenário. A tirania do mérito propõe que para existir uma ética diferente e dignificadora, o sucesso deve ser compreendido em prol da coletividade. Indica que uma alternativa de pensamento guiado pela humildade, pela compreensão do papel do acaso na vida humana e pela criação real da oportunidade poderá ser, então, a melhor bússola para a democracia, para o bem comum. O livro foi publicado no Brasil pela editora Civilização Brasileira em 2020. Pra conversar sobre as reflexões inspiradas pelo livro, Ju Wallauer recebe o advogado e professor Thiago Amparo. Dá o play e vem com a gente! _____ NOVALGINA Se você estiver sentindo aquela dor forte intensa ou febre, não precisa ficar sofrendo esperando passar. Para esses momentos, vale ter Novalgina 1 grama em casa. Ela combate a dor intensa e a febre em minutos. Novalgina é um medicamento à base de dipirona de dupla ação, é analgésico e antitérmico. Além de ser uma marca de confiança, que há mais de 100 anos ajuda a cuidar das famílias brasileiras, é também a mais recomendada pelos médicos. É uma escolha certeira: vale o que custa, vale cada comprimido Acesse novalgina.com.br pra saber mais NOVALGINA® (dipirona monoidratada). Indicação: analgésico e antitérmico. M.S.: 1.8326.0351. O USO DO MEDICAMENTO PODE TRAZER ALGUNS RISCOS. Leia atentamente a bula. SE PERSISTIREM OS SINTOMAS, O MÉDICO DEVERÁ SER CONSULTADO. Junho/2023. MAT-BR-2303214. “combate a dor intensa e a febre em minutos”: 1- Bula Novalgina - profissional de saúde. *Início de ação de 30 a 60 minutos. 2- Ajgaonkar VS, Marathe SN, Virani AR. Dipyrone versus paracetamol: a double-blind study in typhoid fever. J Int Med Res. 1988 May-Jun;16(3):225-30. 3- Tulunay FC et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, cross-over, randomized, placebo-controlled, multi-center study. Funct Neurol. 2004 Jul-Sep;19(3):197-202. “É também a mais recomendada pelos médicos: 4- IQVIA GPS FY'22 – Valores RX – Mercado de Analgésicos OTC _____ FALE CONOSCO . Email: mamilos@b9.com.br _____ CONTRIBUA COM O MAMILOS Quem apoia o Mamilos ajuda a manter o podcast no ar e ainda participa do nosso grupo especial no Telegram. É só R$9,90 por mês! Quem assina não abre mão. https://www.catarse.me/mamilos _____ Equipe Mamilos Mamilos é uma produção do B9 A apresentação é de Cris Bartis e Ju Wallauer. Pra ouvir todos episódios, assine nosso feed ou acesse mamilos.b9.com.br Quem coordenou essa produção foi Beatriz Souza. Com a estrutura de pauta e roteiro escrito por Cris Bartis e Ju Wallauer. A edição foi de Mariana Leão e as trilhas sonoras, de Angie Lopez. A coordenação digital é feita por Agê Barros. O B9 tem direção executiva de Cris Bartis, Ju Wallauer e Carlos Merigo. O atendimento e negócios é feito por Telma Zenaro.

Mamileiros e mamiletes, o que inspira o Mamilos Cultura de hoje é o documentário Alma Imoral, disponível no Canal Curta, no YouTube. O documentário “Alma Imoral”, dirigido pelo cineasta Silvio Tendler, reflete sobre os conceitos de corpo e alma, tradição e transcendência, obediência e ruptura, através do livro “A Alma Imoral”, publicado pelo rabino Nilton Bonder. O filme questiona o que acontece quando o “corpo moral” - normalmente apontado como instrumento importante para a preservação da espécie humana - se torna estreito e passa a ser um obstáculo ao futuro da humanidade. Como se dá esse processo imoral de transcendência, de transgressão, para que fronteiras sejam ampliadas? O documentário busca estabelecer pontes entre histórias de personagens da Bíblia que romperam com as tradições em busca de uma nova ordem - como Eva, Abraão, Moisés - e transgressores do nosso tempo em vários campos, como comportamento, ciência e política. Ali podemos ver israelenses que lutam pela paz ao lado de palestinos, rabinos gays, cientistas que defendem teorias controversas, entre outras histórias que expandem as fronteiras da nossa consciência e produzem a possibilidade de evolução. Dá o play e vem com a gente! _____ NOVALGINA Se você estiver sentindo aquela dor forte intensa ou febre, não precisa ficar sofrendo esperando passar. Para esses momentos, vale ter Novalgina 1 grama em casa. Ela combate a dor intensa e a febre em minutos. Novalgina é um medicamento à base de dipirona de dupla ação, é analgésico e antitérmico. Além de ser uma marca de confiança, que há mais de 100 anos ajuda a cuidar das famílias brasileiras, é também a mais recomendada pelos médicos. É uma escolha certeira: vale o que custa, vale cada comprimido Acesse novalgina.com.br pra saber mais NOVALGINA® (dipirona monoidratada). Indicação: analgésico e antitérmico. M.S.: 1.8326.0351. O USO DO MEDICAMENTO PODE TRAZER ALGUNS RISCOS. Leia atentamente a bula. SE PERSISTIREM OS SINTOMAS, O MÉDICO DEVERÁ SER CONSULTADO. Junho/2023. MAT-BR-2303214. “combate a dor intensa e a febre em minutos”: 1- Bula Novalgina - profissional de saúde. *Início de ação de 30 a 60 minutos. 2- Ajgaonkar VS, Marathe SN, Virani AR. Dipyrone versus paracetamol: a double-blind study in typhoid fever. J Int Med Res. 1988 May-Jun;16(3):225-30. 3- Tulunay FC et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, cross-over, randomized, placebo-controlled, multi-center study. Funct Neurol. 2004 Jul-Sep;19(3):197-202. “É também a mais recomendada pelos médicos: 4- IQVIA GPS FY'22 – Valores RX – Mercado de Analgésicos OTC _____ FALE CONOSCO . Email: mamilos@b9.com.br _____ CONTRIBUA COM O MAMILOS Quem apoia o Mamilos ajuda a manter o podcast no ar e ainda participa do nosso grupo especial no Telegram. É só R$9,90 por mês! Quem assina não abre mão. https://www.catarse.me/mamilos _____ Equipe Mamilos Mamilos é uma produção do B9 A apresentação é de Cris Bartis e Ju Wallauer. Pra ouvir todos episódios, assine nosso feed ou acesse mamilos.b9.com.br Quem coordenou essa produção foi Beatriz Souza. Com a estrutura de pauta e roteiro escrito por Cris Bartis e Ju Wallauer. A edição foi de Mariana Leão e as trilhas sonoras, de Angie Lopez. A coordenação digital é feita por Agê Barros. O B9 tem direção executiva de Cris Bartis, Ju Wallauer e Carlos Merigo. O atendimento e negócios é feito por Telma Zenaro.

Mamileiros e mamiletes, o que inspira o Mamilos Cultura de hoje é a série “Xuxa, o documentário”, disponível no Globoplay. A série documental percorre a trajetória de Xuxa, com acervo exclusivo, entrevistas inéditas e reencontros significativos. Com todos os seus episódios já disponíveis, a série sobre Xuxa Meneghel conquistou um recorde de público para a Globo e se transformou no documentário mais visto no Globoplay. Dá o play e vem com a gente! _____ NOVALGINA Se você estiver sentindo aquela dor forte intensa ou febre, não precisa ficar sofrendo esperando passar. Para esses momentos, vale ter Novalgina 1 grama em casa. Ela combate a dor intensa e a febre em minutos. Novalgina é um medicamento à base de dipirona de dupla ação, é analgésico e antitérmico. Além de ser uma marca de confiança, que há mais de 100 anos ajuda a cuidar das famílias brasileiras, é também a mais recomendada pelos médicos. É uma escolha certeira: vale o que custa, vale cada comprimido. Acesse novalgina.com.br pra saber mais NOVALGINA® (dipirona monoidratada). Indicação: analgésico e antitérmico. M.S.: 1.8326.0351. O USO DO MEDICAMENTO PODE TRAZER ALGUNS RISCOS. Leia atentamente a bula. SE PERSISTIREM OS SINTOMAS, O MÉDICO DEVERÁ SER CONSULTADO. Junho/2023. MAT-BR-2303214. “combate a dor intensa e a febre em minutos”: 1- Bula Novalgina - profissional de saúde. *Início de ação de 30 a 60 minutos. 2- Ajgaonkar VS, Marathe SN, Virani AR. Dipyrone versus paracetamol: a double-blind study in typhoid fever. J Int Med Res. 1988 May-Jun;16(3):225-30. 3- Tulunay FC et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, cross-over, randomized, placebo-controlled, multi-center study. Funct Neurol. 2004 Jul-Sep;19(3):197-202. “É também a mais recomendada pelos médicos: 4- IQVIA GPS FY'22 – Valores RX – Mercado de Analgésicos OTC _____ FALE CONOSCO . Email: mamilos@b9.com.br _____ CONTRIBUA COM O MAMILOS Quem apoia o Mamilos ajuda a manter o podcast no ar e ainda participa do nosso grupo especial no Telegram. É só R$9,90 por mês! Quem assina não abre mão. https://www.catarse.me/mamilos _____ Equipe Mamilos Mamilos é uma produção do B9 A apresentação é de Cris Bartis e Ju Wallauer. Pra ouvir todos episódios, assine nosso feed ou acesse mamilos.b9.com.br Quem coordenou essa produção foi Beatriz Souza. Com a estrutura de pauta e roteiro escrito por Cris Bartis e Ju Wallauer. A edição foi de Mariana Leão e as trilhas sonoras, de Angie Lopez. A coordenação digital é feita por Agê Barros. O B9 tem direção executiva de Cris Bartis, Ju Wallauer e Carlos Merigo. O atendimento e negócios é feito por Telma Zenaro.

Mamileiros e mamiletes, o que inspira o Mamilos Cultura é o filme Oppenheimer, dirigido por Christopher Nolan e baseado no livro biográfico vencedor do Prêmio Pulitzer, Prometeu Americano: O Triunfo e a Tragédia de J. Robert Oppenheimer, escrito por Kai Bird e Martin J. Sherwin. Ambientado na Segunda Guerra Mundial, o longa acompanha a vida de J. Robert Oppenheimer (Cillian Murphy), físico teórico da Universidade da Califórnia e diretor do Laboratório de Los Alamos durante o Projeto Manhattan - que tinha a missão de projetar e construir as primeiras bombas atômicas. Pra conversar sobre as reflexões que o filme inspira, Ju Wallauer recebe Bianca Dias, psicanalista, escritora, ensaísta e crítica de arte. Aperta o play e vamos juntos! _____ NOVALGINA Se você estiver sentindo aquela dor forte intensa ou febre, não precisa ficar sofrendo esperando passar. Para esses momentos, vale ter Novalgina 1 grama em casa. Ela combate a dor intensa e a febre em minutos. Novalgina é um medicamento à base de dipirona de dupla ação, é analgésico e antitérmico. Além de ser uma marca de confiança, que há mais de 100 anos ajuda a cuidar das famílias brasileiras, é também a mais recomendada pelos médicos. É uma escolha certeira: vale o que custa, vale cada comprimido Acesse novalgina.com.br pra saber mais NOVALGINA® (dipirona monoidratada). Indicação: analgésico e antitérmico. M.S.: 1.8326.0351. O USO DO MEDICAMENTO PODE TRAZER ALGUNS RISCOS. Leia atentamente a bula. SE PERSISTIREM OS SINTOMAS, O MÉDICO DEVERÁ SER CONSULTADO. Junho/2023. MAT-BR-2303214. “combate a dor intensa e a febre em minutos”: 1- Bula Novalgina - profissional de saúde. *Início de ação de 30 a 60 minutos. 2- Ajgaonkar VS, Marathe SN, Virani AR. Dipyrone versus paracetamol: a double-blind study in typhoid fever. J Int Med Res. 1988 May-Jun;16(3):225-30. 3- Tulunay FC et al. The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, cross-over, randomized, placebo-controlled, multi-center study. Funct Neurol. 2004 Jul-Sep;19(3):197-202. “É também a mais recomendada pelos médicos: 4- IQVIA GPS FY'22 – Valores RX – Mercado de Analgésicos OTC _____ FALE CONOSCO . Email: mamilos@b9.com.br _____ CONTRIBUA COM O MAMILOS Quem apoia o Mamilos ajuda a manter o podcast no ar e ainda participa do nosso grupo especial no Telegram. É só R$9,90 por mês! Quem assina não abre mão. https://www.catarse.me/mamilos _____ Equipe Mamilos Mamilos é uma produção do B9 A apresentação é de Cris Bartis e Ju Wallauer. Pra ouvir todos episódios, assine nosso feed ou acesse mamilos.b9.com.br Quem coordenou essa produção foi Beatriz Souza. Com a estrutura de pauta e roteiro escrito por Cris Bartis e Ju Wallauer. A edição foi de Mariana Leão e as trilhas sonoras, de Angie Lopez. A coordenação digital é feita por Agê Barros. O B9 tem direção executiva de Cris Bartis, Ju Wallauer e Carlos Merigo. O atendimento e negócios é feito por Telma Zenaro.

"Hounds of Thule" was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003, visit www.darkmattermagazine.shop.  CREDITS Written by Christine Lucas Performed by Erika Sanderson Sound Design by Alli Nesbit Produced by Phil McLaughlin

When you think of foundational clinical vestibular research, there is no doubt you think of one if not both of these individuals. Separately, they have contributed significantly to the profession and together, their collaborations have been transformative to the future of vestibular. Watch to hear us talk to Gary and Devin about where they started, how to promote successful research collaborations, and where they see the future of vestibular going. Here are some research articles Dr. Jacobson and Dr. McCaslin wanted to share with you: Development of the Tinnitus Handicap Inventory. Newman CW, Jacobson GP, Spitzer JB.Arch Otolaryngol Head Neck Surg. 1996 Feb;122(2):143-8. doi: 10.1001/archotol.1996.01890140029007.PMID: 8630207 Test-Retest Reliability of the Dizziness Symptom Profile. Landon-Lane RL, Piker EG, Jacobson GP, Hatton K, Roberts RA.Ear Hear. 2021 Jan/Feb;42(1):206-213. doi: 10.1097/AUD.0000000000000918.PMID: 32701727 Development and Preliminary Findings of the Dizziness Symptom Profile. Jacobson GP, Piker EG, Hatton K, Watford KE, Trone T, McCaslin DL, Bennett ML, Rivas A, Haynes DS, Roberts RA.Ear Hear. 2019 May/Jun;40(3):568-576. doi: 10.1097/AUD.0000000000000628.PMID: 29979254 Effects of age on the tuning of the cVEMP and oVEMP. Piker EG, Jacobson GP, Burkard RF, McCaslin DL, Hood LJ.Ear Hear. 2013 Nov-Dec;34(6):e65-73. doi: 10.1097/AUD.0b013e31828fc9f2.PMID: 23673615 Free PMC article. Intraoperative evoked potential monitoring. Jacobson GP, Tew JM Jr.J Clin Neurophysiol. 1987 Apr;4(2):145-76. doi: 10.1097/00004691-198704000-00004.PMID: 3305572 Review. A Comparison of Dizziness Handicap Inventory Scores by Categories of Vestibular Diagnoses Graham, M. K., Staab, J. P., Lohse, C. M., & McCaslin, D. L. (2021). A Comparison of Dizziness Handicap Inventory Scores by Categories of Vestibular Diagnoses. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 42(1), 129–136. https://doi.org/10.1097/MAO.000000000... The Component Structure of the Dizziness Handicap Inventory (DHI): A Reappraisal Van De Wyngaerde, K. M., Lee, M. K., Jacobson, G. P., Pasupathy, K., Romero-Brufau, S., & McCaslin, D. L. (2019). The Component Structure of the Dizziness Handicap Inventory (DHI): A Reappraisal. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 40(9), 1217–1223. https://doi.org/10.1097/MAO.000000000... The dissociation of video head impulse test (vHIT) and bithermal caloric test results provide topological localization of vestibular system impairment in patients with "definite" Ménière's disease McCaslin, D. L., Rivas, A., Jacobson, G. P., & Bennett, M. L. (2015). The dissociation of video head impulse test (vHIT) and bithermal caloric test results provide topological localization of vestibular system impairment in patients with "definite" Ménière's disease. American journal of audiology, 24(1), 1–10. https://doi.org/10.1044/2014_AJA-14-0040

INCOME REPORT - If you're not measuring what you're doing each month, it makes it difficult to make insightful decisions in the business, know what to change or know what to focus on the next month. Each month I go over my business revenue for Design and Coaching, expenses in the business, KPI's and some wins/loses in hopes to help you in your business.

"Drop Shipment Standard Procedure" was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003, visit www.darkmattermagazine.shop.  Keep your eyes on Fantasia International Film Festival, we'll be debuting our anthology Haunted Reels! CREDITS Written by Marie Croke Performed by Shaina Summerville Sound Design by Alli Nesbit Produced by Phil McLaughlin

There is nothing more stressful than seeing EMS peri-arrest progress to pulseless. CARES data suggest that cardiac arrest during transport is not an uncommon event. Additionally, there is new evidence that these patients may not be as difficult to recognize as we might've thought. Join the podcast crew as we introduce the MCHD "MOVES" algorithm for a proactive approach to providing a safety net before transporting our critical patients. REFERENCES 1. Clemency BM, Murk W, Moore A, Brown LH. The EMS Modified Early Warning Score (EMEWS): A Simple Count of Vital Signs as a Predictor of Out-of-Hospital Cardiac Arrests. Prehosp Emerg Care. 2022 May-Jun;26(3):391-399. 2. Burnett SJ, Innes JC, Varughese R, Frazer E, Clemency BM. A Qualitative Analysis of the Experiences of EMS Clinicians in Recognizing and Treating Witnessed Cardiac Arrests. Prehosp Emerg Care. 2022 Sep 28:1-9.

After returning to the US in late April 2022, The War On Drugs took a short break berore heading back out on an intense 7-week tour that took the band to Mexico, across the US, and back to Europe.  After a massive show with The Strokes in Mexico City, the band returned to the US for a tour that concluded at Bonnaroo in June.  They made a quick turnaround, and headed back to Europe for a show opening for The Rolling Stones in London, as well as run of mostly festival dates across Europe.  Despite a Covid outbreak that took down 3 members of the tour party simultaneously, the band and crew rallied to support each other once more, and by the time they returned to the States in early July, they'd successfully crushed another 28 shows.Host: Dominic EastGuests: Adam Granduciel, Dave Hartley, Robbie Bennett, Charlie Hall, Anthony LaMarca, Jon Natchez, Eliza Hardy-Jones, Craig McQuiston

"Check, Please." was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003, visit www.darkmattermagazine.shop.  Keep your eyes on Fantasia International Film Festival, we'll be debuting our anthology Haunted Reels! CREDITS Written by Sophie Jaff Performed by Alli Nesbit Sound Design by Alli Nesbit Produced by Phil McLaughlin

"The House of Shapes" was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003, visit www.darkmattermagazine.shop.  "Linghun" by Ai Jiang is a tale of haunting specters and the grief sick town that perpetuates them.  "Linghun" is our first Dark Matter INK audiobook: now available now in our shop! CREDITS Written by Hailey Piper Performed by Piper Reese Sound Design and Editing by Alli Nesbit Produced by Phil McLaughlin

David Acín (007_David_Acín) con Eduardo (Edu_150) y otro Eduardo (Ebardo) desmenuzan la segunda película de Sean Connery como James Bond, una de las favoritas del público: 00:00:00 Presentación 00:03:26 Saludo a Edu_150 00:04:58 Promo Taller Skywalker 00:05:36 Opiniones de los oyentes 00:09:28 El espontáneo 00:11:47 Noticias del mes 00:25:06 La noticia del mes 00:27:53 Efemérides 00:30:02 Promo Ian Fleming y James Bond: Conexión España 00:31:20 Debate Desde Rusia con amor con Edu_150 y Ebardo 01:44:00 Promo Club Archivo 007 01:44:28 Despedida 01:45:58 Tema final

You Are More Than Just Your Breast Cancer - Hormones and Breast Cancer   Dr. Corinne Menn is a board certified OBGYN and North American Menopause Society Certified Menopause Practitioner. She has a special interest in areas often neglected in women's health: Perimenopause and menopause, the unique needs of female cancer survivors and those at high risk for breast cancer.    Dr. Menn tells us her story of breast cancer dx at age 28, going through menopause three times and is now a pro-hormone educator.   Dr. Menn discusses taking systemic hormones and her journey and how it has changed her life.   Why are doctors and patients so afraid of hormones?   Doctors are so risk adverse – but let's talk about the risks of not treating menopause.   The myth that estrogen causes cancer.   How Tamoxifen works.   Breast cancer nomenclature – estrogen positive – this doesn't mean estrogen caused the cancer – we clarify.   The nuance of being overweight and risk of breast cancer.   The number one killer of women with history of breast cancer is heart disease.   Safety of systemic hormone replacement therapy in breast cancer survivors Article in Breast Cancer Research and Treatment · January 2022 – Dr Bluming -       "Twenty-five studies of HRT after a breast cancer diagnosis, published between 1980 and 2013, are discussed, as are the 20 reviews of those studies published between 1994 and 2021. Only 1 of the 25 studies, the HABITS trial, demonstrated an increased risk of recurrence, which was limited to local or contralateral, and not distant, recurrence. None of the studies, including HABITS, reported increased breast cancer mortality associated with HRT. Even in the HABITS trial, the absolute increase in the number of women who had a recurrence (localized only) associated with HRT administration was 22. It is on the basis of these 22 patients that HRT, with its demonstrated benefits for so many aspects of women's health, is being denied to millions of breast cancer survivors around the world."   The problem with the HABITS trial.   Why are we scaring women so much about breast cancer?   Who is the right breast cancer survivor to start hormones? A good candidate?   Are we overtreating with aromatase inhibitors? Podcast partnership today: Always Discreet https://www.instagram.com/alwaysdiscreet/   Bluming AZ. Hormone Replacement Therapy After Breast Cancer: It Is Time. Cancer J. 2022 May-Jun 01;28(3):183-190.   Young Survival Coalition https://youngsurvival.org/   Vaginal Estrogen for people with a history of breast cancer: https://www.acog.org/clinical/clinical-guidance/clinical-consensus/articles/2021/12/treatment-of-urogenital-symptoms-in-individuals-with-a-history-of-estrogen-dependent-breast-cancer   Dr. Menn is an Alloy Health Medical Advisor and Prescriber www.myalloy.com http://www.drmenn.com/ https://www.instagram.com/drmennobgyn https://www.tiktok.com/@drmennobgyn https://www.facebook.com/drmenn

Morton's Neuroma Diagnosis Treatment and Regenerative Medicine Options   Claim CME for listening The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/7Oo1wq Dr Rosenblum discusses Morton's Neuroma and describes typical presentation, diagnosis, treatments such as corticosteroid injection, nerve ablation, regenerative medicine and more!     Morton's neuroma is a painful condition that affects the foot, specifically the ball of the foot. It occurs when the tissue surrounding the nerves leading to the toes thickens, causing intense pain, numbness, or a burning sensation.   Course Calendar   Practice Management Webinar: The End of the Public Health Emergency. What's Changed and what Opportunities Remain! Regenerative Pain Medicine Course NYC- May 13 Pain Management Board Review/Refresher Course/ Ultrasound Training NYC- June 9-11, 2023  Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- July 19, 2023 Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- August 19th, 2023 Ultrasound Guided Regional Anesthesia and Pain Medicine- Sept 15, 2023, San Juan, PR For  up to date Calendar, Click Here! References   Platelet-rich-plasma Injection Therapy For Morton's Neuroma - Page #4. https://www.amssm.org/plateletrichplasma_injecti-csa-268.html?StartPos=130&Part=4a Bhatia M, Thomson L. Morton's neuroma - Current concepts review. J Clin Orthop Trauma. 2020 May-Jun;11(3):406-409. doi: 10.1016/j.jcot.2020.03.024. Epub 2020 Apr 10. PMID: 32405199; PMCID: PMC7211826. Barbara De Angelis, Lucilla Lucarini, Fabrizio Orlandi, Annarita Agovino, Alessia Migner, Valerio Cervelli, Valentina Izzo, Cristiano Curcio. Regenerative surgery of the complications with Morton's neuroma surgery: use of platelet rich plasma and hyaluronic acidVolume10, Issue4 August 2013 Pages 372-376

Morton's Neuroma Diagnosis Treatment and Regenerative Medicine Options   Claim CME for listening The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/7Oo1wq Dr Rosenblum discusses Morton's Neuroma and describes typical presentation, diagnosis, treatments such as corticosteroid injection, nerve ablation, regenerative medicine and more!     Morton's neuroma is a painful condition that affects the foot, specifically the ball of the foot. It occurs when the tissue surrounding the nerves leading to the toes thickens, causing intense pain, numbness, or a burning sensation.   Course Calendar   Practice Management Webinar: The End of the Public Health Emergency. What's Changed and what Opportunities Remain! Regenerative Pain Medicine Course NYC- May 13 Pain Management Board Review/Refresher Course/ Ultrasound Training NYC- June 9-11, 2023  Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- July 19, 2023 Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- August 19th, 2023 Ultrasound Guided Regional Anesthesia and Pain Medicine- Sept 15, 2023, San Juan, PR For  up to date Calendar, Click Here! References   Platelet-rich-plasma Injection Therapy For Morton's Neuroma - Page #4. https://www.amssm.org/plateletrichplasma_injecti-csa-268.html?StartPos=130&Part=4a Bhatia M, Thomson L. Morton's neuroma - Current concepts review. J Clin Orthop Trauma. 2020 May-Jun;11(3):406-409. doi: 10.1016/j.jcot.2020.03.024. Epub 2020 Apr 10. PMID: 32405199; PMCID: PMC7211826. Barbara De Angelis, Lucilla Lucarini, Fabrizio Orlandi, Annarita Agovino, Alessia Migner, Valerio Cervelli, Valentina Izzo, Cristiano Curcio. Regenerative surgery of the complications with Morton's neuroma surgery: use of platelet rich plasma and hyaluronic acidVolume10, Issue4 August 2013 Pages 372-376

"Death in the Afternoon" was first published in Issue 003 of Dark Matter Magazine, May-Jun 2021.  To purchase Issue 003, visit www.darkmattermagazine.shop.  "Linghun" by Ai Jiang is a tale of haunting specters and the grief sick town that perpetuates them.  "Linghun" is our first Dark Matter INK audiobook: now available now in our shop!   CREDITS Written by John G. Wimer Performed by Aaron Sinn Sound Design by Alli Nesbit Produced by Phil McLaughlin

Please join Drs. Graham Skelhorne-Gross, Jordan Nantais and Ashlie Nadler from our Emergency General Surgery Team for a discussion on cirrhotic patients.   Child-Pugh Score (https://www.mdcalc.com/calc/340/child-pugh-score-cirrhosis-mortality) ·      Bilirubin, albumin, INR, ascites, encephalopathy ·      Used to predict operative mortality based on cirrhosis severity ·      Mortality in EGS: - Child-Pugh A: 10% electively and 22% emergently - Child-Pugh B: 30% electively and 38% emergently - Child-Pugh C: 80% electively and up to 100% emergently Model for End Stage Liver Disease (MELD) (https://www.mdcalc.com/calc/10437/model-end-stage-liver-disease-meld?utm_source=site&utm_medium=link&utm_campaign=meld_12_and_older) ·      creatinine, bilirubin, INR, and sodium ·      MELD < 20 – 1% increase in mortality with each point increase ·      MELD > 20 – 2% increase in mortality with each point increase Pre-operative Planning ·      Identification of cirrhosis with physical examination, bloodwork and imaging ·      Involvement of other medical services (internal medicine, hepatology, ICU) as needed ·      Cirrhosis optimization, if possible ·      Abdominal wall mapping Unexpected Intraoperative Finding Communicate unexpected findings to the operative team and think of additional adjuncts you may need such as additional ports, topical hemostatic agents or energy devices. Think about why you are in the OR. If its an elective situation and can wait, consider bailing. If its emergent, you may have to do something more definitive. Exposure may be a challenge, you may have to alter your typical approach including where the assistant grabs and retracts. Extra hands are helpful. Bleeding can be a big deal. If possible, map out the abdominal wall ahead of time with cross-sectional imaging. Stay away from varices around the umbilicus or porta Ventral Hernia + Cirrhosis ·      Ideally, control ascites pre-operatively, if you can't consider leaving drains ·      Small (< 2cm) hernias close primarily ·      Larger (>2cm) hernias repair with mesh unless infected filed (controversial) ·      Minimally invasive repairs can be performed Benign Biliary Disease + Cirrhosis ·      Incidence of gallstones is 4-5 times higher in cirrhotic patients ·      Prophylactic laparoscopic cholecystectomy (LC) generally not done ·      LC generally considered acceptable in CP A or B but not C (exceptions: HD instability, gangrenous cholecystitis, hemorrhagic cholecystitis) ·      Cholecystostomy and ERCP are safe References:  Bleszynski, M. et. Al. Acute care and emergency general surgery in patients with chronic liver disease: how can be optimize perioperative care? A review of the literature. 2018. World Journal of Emergency Surgery; 13:32 Mansour A, Watson W, Shayani V, et al. Abdominal operations in patients with cirrhosis: still a major surgical challenge. Surgery. 1997;122:730–5. Yeom SK, Lee CH, Cha SH, Park CM. Prediction of liver cirrhosis, using diagnostic imaging tools. World J Hepatol. 2015 Aug 18;7(17):2069-79. doi: 10.4254/wjh.v7.i17.2069. PMID: 26301049; PMCID: PMC4539400. Jain D, Mahmood E, V-Bandres M, Feyssa E. Preoperative elective transjugular intrahepatic portosystemic shunt for cirrhotic patients undergoing abdominal surgery. Ann Gastroenterol. 2018 May-Jun;31(3):330-337. doi: 10.20524/aog.2018.0249. Epub 2018 Mar 15. PMID: 29720858; PMCID: PMC5924855. **Fellowship application link: https://forms.gle/PiKM2MMQpE5jSAeW7 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other Emergency General Surgery episode here: https://behindtheknife.org/podcast-category/emergency-general-surgery/

Essentially all women eventually enter menopause, and while most end up not taking hormones to treat their symptoms, they at least have the option to do so. Women with a breast cancer diagnosis, on the other hand, generally don't have the same choices at their disposal and are told, or assume, they are not candidates for estrogen therapy. Millions of women are expected to just put up with hot flashes, brain fog, insomnia, and bone loss, not to mention all the changes below the belly button. In this episode, I am joined by Dr. Corinne Menn, a board-certified gynecologist, with expertise in menopause and sexual medicine who was diagnosed with estrogen-positive breast cancer in her 20s.  We will have a radical discussion about options, INCLUDING ESTROGEN to manage hot flashes and insomnia.  In this episode, we discuss: The impact of PREGNANCY on women with breast cancer Non-estrogen prescription options to treat HOT FLASHES SSRI, SNRI  Gabapentin  Oxybutynin  Fezolinetant ESTROGEN THERAPY as an option for women with breast cancer The lack of studies that show estrogen increases the risk of breast cancer recurrence or mortality  The 25 scientific studies that support the safety of taking menopausal estrogen therapy in women with breast cancer  Why physicians continue to tell women to avoid estrogen If it is worth taking herbal or other over-the-counter hot flash remedies Article Dr. Menn references: Bluming AZ. Introduction: Estrogen Reconsidered: Exploring the Evidence for Estrogen's Benefits and Risks. Cancer J. 2022 May-Jun 01;28(3):157-162.  MORE INFORMATION Episode 2:Think Your Hot Flashes Can't Kill You? Think Again! Episode 3: What's Up Down There? Genital Dryness & Misbehaving Bladders  Episode 11: Vaginal Estrogen is Not Poison Episode 31 The TRUTH About Hormone Therapy: Does it CAUSE or Does it PREVENT Breast Cancer?  Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Lauren Streicher, MD is a clinical professor of obstetrics and gynecology at Northwestern University's Feinberg School of Medicine, and the founding medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause. She is a certified menopause practitioner of the North American Menopause Society.  Sign up to receive DR. STREICHER'S FREE NEWSLETTER Dr. Streicher is the medical correspondent for Chicago's top-rated news program, the WGN Morning News, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr. Radio, Nightline, Fox and Friends, The Steve Harvey Show, CBS This Morning, ABC News Now, NBCNightlyNews,20/20, and World News Tonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine, and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.  Subscribe and Follow Dr. Streicher on  DrStreicher.com Instagram @DrStreich Twitter @DrStreicher Facebook  @DrStreicher YouTube  DrStreicherTV Books by Lauren Streicher, MD  Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Sex Rx- Hormones, Health, and Your Best Sex Ever The Essential Guide to Hysterectomy

Meu paciente não fala. E agora? É possível saber se nosso paciente que não consegue se expressar através da fala está com dor? Ou com falta de ar? Consigo escutar meu paciente… mesmo que por alguma doença ou circunstância ele não consiga falar? Referência da escala citada: Azevedo-Santos IF, Alves IGN, Cerqueira Neto et al. Validação da versão Brasileira da Escala Comportamental de Dor (Behavioral Pain Scale) em adultos sedados e sob ventilação mecânica [Validation of the Brazilian version of Behavioral Pain Scale in adult sedated and mechanically ventilated patients]. Rev Bras Anestesiol. 2017 May-Jun;67(3):271-277. Portuguese. doi: 10.1016/j.bjan.2015.11.006. Epub 2017 Mar 1. PMID: 28258734.

In this special annual episode we look back at 2022 and ask the I Ching what our learning should have been in the powerful year just past. And then we look to 2023 and explore through the I Ching where our focus should be to really maximise the goodness of the year ahead. Listen to this episode for more insight into how to work with this flow this week. I Ching Resources, Links and Giveaways: https://linktr.ee/ichingcafe Timestamps 0:00 Intro 5:50 2022 Learning - Hexagram 53 Development 7:04 2022 Learning - Hexagram 53 Development, Changing Line 1 7:42 2022 Learning - Hexagram 37 The Family 9:46 2023 Focus - Hexagram 63 After Completion 12:46 2023 Focus - Hexagram 38 Opposition 16:09 2023 Focus - Hexagram 63 After Completion, Changing Line 2, Jan-Feb 2023 17:53 2023 Focus - Hexagram 63 After Completion, Changing Line 3, Mar-Apr 2023 19:22 2023 Focus - Hexagram 63 After Completion, Changing Line 4, May-Jun 2023 20:22 2023 Focus - Hexagram 63 After Completion, Changing Line 5, Jul-Aug 2023 21:21 2023 Focus - Hexagram 63 After Completion, Changing Line 6, Sep-Oct 2023 Tech Specs 2022 Learning Main or Present Hexagram - Hexagram 53 Development Changing Lines - 1st Position Outcome Hexagram - Hexagram 37 The Family 2023 Focus Main or Present Hexagram - Hexagram 63 After Completion Changing Lines - 2nd, 3rd, 4th, 5th and 6th Positions Outcome Hexagram - Hexagram 38 Opposition

Smerter i fremre del av foten litt ut mot siden når du går eller står på tå? Mortons Nevrom er en svært vanlig plage i foten som ofte kommer etter lange gåturer eller bruk av smale sko. I denne episoden snakke Edgeir og Sindre om diagnose, behandling og forebygging. Vi har også et spesielt råd til deg som sliter med dette.   Litteratur:  Morton's neuroma - Current concepts review. Bhatia M, Thomson L. J Clin Orthop Trauma. 2020 May-Jun;11(3):406-409. doi: 10.1016/j.jcot.2020.03.024. Epub 2020 Apr 10. Review. Morton's neuroma: review of anatomy, pathomechanism, and imaging. Mak MS, Chowdhury R, Johnson R. Clin Radiol. 2021. Review.

Dr. Kimberly Blumenthal (@KimberlyBlumen1), Dr. Meghan Jeffres (@PharmerMeg), and Dr. Eric Macy (@EricMacyMD) join Dr. Julie Ann Justo (@julie_justo) to summarize the history of cephalosporin avoidance in penicillin allergies, evidence-based pros and cons of giving cephalosporins in penicillin allergy, how to leverage technology to improve treatment of patients with penicillin allergies, and much more! Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/ References Macy E. Why Was There Ever a Warning Not to Use Cephalosporins in the Setting of a Penicillin "Allergy"? J Allergy Clin Immunol Pract. 2021 Nov;9(11):3929-3933. doi: 10.1016/j.jaip.2021.06.059. PMID: 34303019. Liang EH, et al. Adverse Reactions Associated with Penicillins, Carbapenems, Monobactams, and Clindamycin: A Retrospective Population-based Study. J Allergy Clin Immunol Pract. 2020 Apr;8(4):1302-1313.e2. doi: 10.1016/j.jaip.2019.11.035. PMID: 31821919. Macy E, Contreras R. Adverse reactions associated with oral and parenteral use of cephalosporins: A retrospective population-based analysis. J Allergy Clin Immunol. 2015 Mar;135(3):745-52.e5. doi: 10.1016/j.jaci.2014.07.062. PMID: 25262461. Macy E, et al. Population-Based Incidence of New Ampicillin, Cephalexin, Cefaclor, and Sulfonamide Antibiotic "Allergies" in Exposed Individuals with and without Preexisting Ampicillin, Cephalexin, or Cefaclor "Allergies". J Allergy Clin Immunol Pract. 2022 Feb;10(2):550-555. doi: 10.1016/j.jaip.2021.10.043. PMID: 34757066. Picard M, et al. Cross-Reactivity to Cephalosporins and Carbapenems in Penicillin-Allergic Patients: Two Systematic Reviews and Meta-Analyses. J Allergy Clin Immunol Pract. 2019 Nov-Dec;7(8):2722-2738.e5. doi: 10.1016/j.jaip.2019.05.038. PMID: 31170539. Romano A, et al. Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2016 Jul;138(1):179-186. doi: 10.1016/j.jaci.2016.01.025. PMID: 27016799. Romano A, et al. Cross-Reactivity and Tolerability of Cephalosporins in Patients with IgE-Mediated Hypersensitivity to Penicillins. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1662-1672. doi: 10.1016/j.jaip.2018.01.020. PMID: 29408440. Blumenthal KG, et al. The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. Clin Infect Dis. 2018 Jan 18;66(3):329-336. doi: 10.1093/cid/cix794. PMID: 29361015. Blumenthal KG, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018 Jun 27;361:k2400. doi: 10.1136/bmj.k2400. PMID: 29950489. Blumenthal KG, et al. Recorded Penicillin Allergy and Risk of Mortality: a Population-Based Matched Cohort Study. J Gen Intern Med. 2019 Sep;34(9):1685-1687. doi: 10.1007/s11606-019-04991-y. PMID: 31011962. Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin "allergy" in hospitalized patients: A cohort study. J Allergy Clin Immunol. 2014 Mar;133(3):790-6. doi: 10.1016/j.jaci.2013.09.021. PMID: 24188976. AAAI. Choosing Wisely. 2014 Mar 3. https://www.choosingwisely.org/clinician-lists/american-academy-allergy-asthma-immunlogy-non-beta-lactam-antibiotics-penicillin-allergy/ Jeffres MN, et al. Systematic review of professional liability when prescribing β-lactams for patients with a known penicillin allergy. Ann Allergy Asthma Immunol. 2018 Nov;121(5):530-536. doi: 10.1016/j.anai.2018.03.010. PMID: 29551402. Macy E, et al. Association Between Removal of a Warning Against Cephalosporin Use in Patients With Penicillin Allergy and Antibiotic Prescribing. JAMA Netw Open. 2021 Apr 1;4(4):e218367. doi: 10.1001/jamanetworkopen.2021.8367. PMID: 33914051. Blumenthal KG, et al. Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation. J Allergy Clin Immunol Pract. 2017 May-Jun;5(3):616-625.e7. doi: 10.1016/j.jaip.2017.02.019. PMID: 28483315. Jeffres M. Penicillin and/or Beta-Lactam Allergy Tip Sheet & Cross-reactivity Table. https://drive.google.com/file/d/1cokYXnSDlO3vk8ke1LaalPz4iavuNSV8/view?usp=share_link Khan DA, et al. Drug allergy: A 2022 practice parameter update. J Allergy Clin Immunol. 2022 Sep 17:S0091-6749(22)01186-1. doi: 10.1016/j.jaci.2022.08.028. Epub ahead of print. PMID: 36122788. Guyer AC, et al. Allergy Electronic Health Record Documentation: A 2022 Work Group Report of the AAAAI Adverse Reactions to Drugs, Biologicals, and Latex Committee. J Allergy Clin Immunol Pract. 2022 Nov;10(11):2854-2867. doi: 10.1016/j.jaip.2022.08.020. PMID: 36151034. Iammatteo M, et al. Safety and Outcomes of Oral Graded Challenges to Amoxicillin without Prior Skin Testing. J Allergy Clin Immunol Pract. 2019 Jan;7(1):236-243. doi: 10.1016/j.jaip.2018.05.008. PMID: 29802906. Bavbek S, et al. Determinants of nocebo effect during oral drug provocation tests. Allergol Immunopathol (Madr). 2015 Jul-Aug;43(4):339-45. doi: 10.1016/j.aller.2014.04.008. PMID: 25088674. DePestel DD, et al. Cephalosporin use in treatment of patients with penicillin allergies. J Am Pharm Assoc (2003). 2008 Jul-Aug;48(4):530-40. doi: 10.1331/JAPhA.2008.07006. PMID: 18653431. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. 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Today in our sixth episode of Insights in Clinical Nutrition, we continue talking with special guest Emma Osland. Emma is an Advanced Accredited Practicing Dietitian currently based at the Royal Brisbane and Women's Hospital. Throughout her career to date, Emma has worked across a broad range of practice areas and is recognised for her expertise in the area of nutrition support. Emma has taken a lead role in developing AuSPEN's Adult Trace Element and Vitamin Guidelines for adults requiring parenteral nutrition and the AuSPEN Quality Framework for Home Parenteral Nutrition Provision. She is an active member of the AuSPEN HPN Model of Care working group, who are continuing to work towards laying the foundations required to establish a national model of care for HPN in Australia.   Email: podcast@auspen.org.au Website: www.auspen.org.au/podcast References:1.     Ambrose T, De Silva A, Naghibi M, Saunders J, Smith TR, Coleman RL, Stroud M. Refeeding risks in patients requiring intravenous nutrition support: Results of a two-centre, prospective, double-blind, randomised controlled trial. Clin Nutr ESPEN. 2021 Feb;41:143-152. doi: 10.1016/j.clnesp.2020.11.028. Epub 2021 Jan 8. PMID: 33487258.2.     Blaauw R, Osland E, Sriram K, Ali A, Allard JP, Ball P, Chan LN, Jurewitsch B, Logan Coughlin K, Manzanares W, Menéndez AM, Mutiara R, Rosenfeld R, Sioson M, Visser J, Berger MM. Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper. JPEN J Parenter Enteral Nutr. 2019 Mar;43 Suppl 1:S5-S23. doi: 10.1002/jpen.1525. PMID: 30812055.3.     Dudrick SJ. History of parenteral nutrition. J Am Coll Nutr. 2009 Jun;28(3):243-51. doi: 10.1080/07315724.2009.10719778. PMID: 20150597.4.     Ferrie, S. (2019). Does infusion time affect the retention of parenteral trace elements? British Journal of Nutrition, 122(1), 56-62. doi:10.1017/S0007114519000965.5.     Klek S, Szczepanek K, Scislo L, Walewska E, Pietka M, Pisarska M, Pedziwiatr M. Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results from a randomized clinical trial. Nutrition. 2018 Nov;55-56:45-50. doi: 10.1016/j.nut.2018.03.008. Epub 2018 Mar 22. PMID: 29960156.6.     Osland EJ, Ali A, Isenring E, Ball P, Davis M, Gillanders L. Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition. Asia Pac J Clin Nutr. 2014;23(4):545-54. doi: 10.6133/apjcn.2014.23.4.21. PMID: 25516311.7.     Osland EJ, Ali A, Nguyen T, Davis M, Gillanders L. Australasian society for parenteral and enteral nutrition (AuSPEN) adult vitamin guidelines for parenteral nutrition. Asia Pac J Clin Nutr. 2016;25(3):636-50. doi: 10.6133/apjcn.022016.05. PMID: 27440700.8.     Osowska S, Kunecki M, Sobocki J, Tokarczyk J, Majewska K, Omidi M, Radkowski M, Fisk HL, Calder PC. Effect of changing the lipid component of home parenteral nutrition in adults. Clin Nutr. 2019 Jun;38(3):1355-1361. doi: 10.1016/j.clnu.2018.05.028. Epub 2018 Jun 6. PMID: 29907355.9.     Rio A, Whelan K, Goff L, Reidlinger DP, Smeeton N. Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study. BMJ Open. 2013 Jan 11;3(1):e002173. doi: 10.1136/bmjopen-2012-002173. PMID: 23315514; PMCID: PMC3549252.10.  Vinnars E, Wilmore D. Jonathan Roads Symposium Papers. History of parenteral nutrition. JPEN J Parenter Enteral Nutr. 2003 May-Jun;27(3):225-31. doi: 10.1177/0148607103027003225. PMID: 12757118.

Today in our fifth episode of Insights in Clinical Nutrition, we talk with special guest Emma Osland. Emma is an Advanced Accredited Practicing Dietitian currently based at the Royal Brisbane and Women's Hospital. Throughout her career to date, Emma has worked across a broad range of practice areas and is recognised for her expertise in the area of nutrition support. Emma has taken a lead role in developing AuSPEN's Adult Trace Element and Vitamin Guidelines for adults requiring parenteral nutrition and the AuSPEN Quality Framework for Home Parenteral Nutrition Provision. She is an active member of the AuSPEN HPN Model of Care working group, who are continuing to work towards laying the foundations required to establish a national model of care for HPN in Australia.  Please note that the information shared in this podcast is for educational purposes only and does not constitute medical advice.  Email: podcast@auspen.org.au Website: www.auspen.org.au/podcastReferences:1.     Ambrose T, De Silva A, Naghibi M, Saunders J, Smith TR, Coleman RL, Stroud M. Refeeding risks in patients requiring intravenous nutrition support: Results of a two-centre, prospective, double-blind, randomised controlled trial. Clin Nutr ESPEN. 2021 Feb;41:143-152. doi: 10.1016/j.clnesp.2020.11.028. Epub 2021 Jan 8. PMID: 33487258. 2.     Blaauw R, Osland E, Sriram K, Ali A, Allard JP, Ball P, Chan LN, Jurewitsch B, Logan Coughlin K, Manzanares W, Menéndez AM, Mutiara R, Rosenfeld R, Sioson M, Visser J, Berger MM. Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper. JPEN J Parenter Enteral Nutr. 2019 Mar;43 Suppl 1:S5-S23. doi: 10.1002/jpen.1525. PMID: 30812055.  3.     Dudrick SJ. History of parenteral nutrition. J Am Coll Nutr. 2009 Jun;28(3):243-51. doi: 10.1080/07315724.2009.10719778. PMID: 20150597.  4.     Ferrie, S. (2019). Does infusion time affect the retention of parenteral trace elements? British Journal of Nutrition, 122(1), 56-62. doi:10.1017/S0007114519000965..  5.     Klek S, Szczepanek K, Scislo L, Walewska E, Pietka M, Pisarska M, Pedziwiatr M. Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results from a randomized clinical trial. Nutrition. 2018 Nov;55-56:45-50. doi: 10.1016/j.nut.2018.03.008. Epub 2018 Mar 22. PMID: 29960156. 6.     Osland EJ, Ali A, Isenring E, Ball P, Davis M, Gillanders L. Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition. Asia Pac J Clin Nutr. 2014;23(4):545-54. doi: 10.6133/apjcn.2014.23.4.21. PMID: 25516311 7.     Osland EJ, Ali A, Nguyen T, Davis M, Gillanders L. Australasian society for parenteral and enteral nutrition (AuSPEN) adult vitamin guidelines for parenteral nutrition. Asia Pac J Clin Nutr. 2016;25(3):636-50. doi: 10.6133/apjcn.022016.05. PMID: 27440700.8.     Osowska S, Kunecki M, Sobocki J, Tokarczyk J, Majewska K, Omidi M, Radkowski M, Fisk HL, Calder PC. Effect of changing the lipid component of home parenteral nutrition in adults. Clin Nutr. 2019 Jun;38(3):1355-1361. doi: 10.1016/j.clnu.2018.05.028. Epub 2018 Jun 6. PMID: 29907355.9.     Rio A, Whelan K, Goff L, Reidlinger DP, Smeeton N. Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study. BMJ Open. 2013 Jan 11;3(1):e002173. doi: 10.1136/bmjopen-2012-002173. PMID: 23315514; PMCID: PMC3549252.10.  Vinnars E, Wilmore D. Jonathan Roads Symposium Papers. History of parenteral nutrition. JPEN J Parenter Enteral Nutr. 2003 May-Jun;27(3):225-31. doi: 10.1177/0148607103027003225. PMID: 12757118.

No episódio de hoje Tiago Meira e Fabio Fernandes fazem uma prévia da maior premiação de ficção científica e fantasia do mundo, o Hugo Award 2022, destacando os favoritos das principais categorias e contando algumas curiosidade sobre a história dessa tradicional premiação  Categoria e indicados: Best Novel -A Desolation Called Peace, by Arkady Martine (Tor) -The Galaxy, and the Ground Within, by Becky Chambers (Harper Voyager / Hodder & Stoughton) -Light From Uncommon Stars, by Ryka Aoki (Tor / St Martin's Press) -A Master of Djinn, by P. Djèlí Clark (Tordotcom / Orbit UK) -Project Hail Mary, by Andy Weir (Ballantine / Del Rey) -She Who Became the Sun, by Shelley Parker-Chan (Tor / Mantle) Best Novella -Across the Green Grass Fields, by Seanan McGuire (Tordotcom) -Elder Race, by Adrian Tchaikovsky (Tordotcom) -Fireheart Tiger, by Aliette de Bodard (Tordotcom) -The Past Is Red, by Catherynne M. Valente (Tordotcom) -A Psalm for the Wild-Built, by Becky Chambers (Tordotcom) -A Spindle Splintered, by Alix E. Harrow (Tordotcom) Best Novelette -Bots of the Lost Ark, by Suzanne Palmer (Clarkesworld, Jun 2021) -Colors of the Immortal Palette, by Caroline M. Yoachim (Uncanny Magazine, Mar/Apr 2021) -L'Esprit de L'Escalier, by Catherynne M. Valente (Tordotcom) -O2 Arena, by Oghenechovwe Donald Ekpeki (Galaxy's Edge, Nov 2021) -That Story Isn't the Story, by John Wiswell (Uncanny Magazine, Nov/Dec 2021) -Unseelie Brothers, Ltd., by Fran Wilde (Uncanny Magazine, May/Jun 2021) Best Short Story 632 ballots for 589 nominees; finalist range 44-96 -Mr. Death, by Alix E. Harrow (Apex Magazine, Feb 2021) -Proof by Induction, by José Pablo Iriarte (Uncanny Magazine, May/Jun 2021) -The Sin of America, by Catherynne M. Valente (Uncanny Magazine, Mar/Apr 2021) -Tangles, by Seanan McGuire (Magicthegathering.com: Magic Story, Sep 2021) -Unknown Number, by Blue Neustifter (Twitter, Jul 2021) -Where Oaken Hearts Do Gather, by Sarah Pinsker (Uncanny Magazine, Mar/Apr 2021) Siga o Viva Sci-Fi no Instagram: https://www.instagram.com/vivascifi/ Siga o Viva Sci-Fi no Twitter: https://twitter.com/vivascifi?t=MP2-Vm3OqYmmo7_xwIfQDQ&s=09 Canal no youtube do Fabio Fernandes: https://www.youtube.com/c/TerraIncognitaBooksNStuff Site do Fabio Fernandes: https://fabiofernandeswriter.com/ Editado por OITOPIX: https://www.instagram.com/oitopix/

ORAL MINOXIDIL IN PEDIATRICS   Jerjen R et al (starts at 12:33). Low-dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome. Br J Dermatol. 2021;184(5):977-978. Nicolas-Ruanes et al (starts at 15:33). Low-dose oral minoxidil for treatment of androgenetic alopecia and telogen effluvium in a pediatric population: A descriptive study. J Am Acad Dermatol. 2022 Apr 26; John JM et al (starts at 17:24). Safety and tolerability of low-dose oral minoxidil in adolescents: A retrospective review. J Am Acad Dermatol . 2022 Jul 5;S0190-9622(22)02245-9.   HAIR FIBERS AND CAMOUFLAGE Ring and Keller (starts at 25:13). Effect of camouflaging agents on psychologic well-being: A cross-sectional survey of hair loss patients. J Am Acad Dermatol. 2017 Jun;76(6):1186-1189 Babadjouni A et al (starts at 28:15). Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers. Int J Trichology. 2022 May-Jun; 14(3): 97–102   HYDROXYCHLOROQUINE IN PREGNANCY Reynolds JA et al (starts at 34:38). Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine. Rheumatology (Oxford). 2022 Jun 29: Sperber K et al (starts at 38:25). Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases. Pediatr Rheumatol Online J 2009;7:9. Kaplan Y et al (starts at 39:17). Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016 May;81(5):835-48. Clowse MEB et al (starts at 40:27). Hydroxychloroquine in the pregnancies of women with lupus: a meta-analysis of individual participant data. Lupus Sci Med. 2022 Mar;9(1):e000651. Huybrechts K et al (starts at 42:37). Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol 2021 Mar;224(3):290.e1-290.e22 Huybrechts K et al (starts at 45:20). Hydroxychloroquine early in pregnancy and risk of birth defects: absence of evidence is not the same as evidence of absence. Am J Obstet Gynecol. 2021 May;224(5):549-550. Bérard et al (starts at 46:58). Chloroquine and Hydroxychloroquine Use During Pregnancy and the Risk of Adverse Pregnancy Outcomes Using Real-World Evidence. Front Pharmacol. 2021 Aug 2;12:722511. Howley et al (starts at 47:17). Maternal exposure to hydroxychloroquine and birth defects. Birth Defects Res. 2021 Oct 15;113(17):1245-1256. Andersson et al (starts at 47:34). Fetal safety of chloroquine and hydroxychloroquine use during pregnancy: a nationwide cohort study. Rheumatology (Oxford). 2021 May 14;60(5):2317-2326.   TERIFLUNOMIDE INDUCED HAIR LOSS IN MULTIPLE SCLEROSIS Travis LH et al (starts at 53:28). Real-World Observational Evaluation of Hair Thinning in Patients with Multiple Sclerosis Receiving Teriflunomide: Is It an Issue in Clinical Practice? Neurol Ther. 2018 Dec; 7(2): 341–347. Porwal MH et al (starts at 55:41). Alopecia in Multiple Sclerosis Patients Treated with Disease Modifying Therapies. J Cent Nerv Syst Dis. 2022 Jun 23;14:11795735221109674.   DO IT YOURSELF LOW-ALLERGEN PRODUCTS Xiong M and Warshaw EM. (starts at 1:05:45) Hair Care Product Hacks: Do It Yourself Alternatives. Dermatitis. 2022 Jun 29. Zirwas M and Moennich J (starts at 1:00:25). Shampoos. Dermatitis. 2009 Mar-Apr;20(2):106-10 Tawfik M, Rodriguez-Homs LG, Alexander T, et al (starts at 1:01:10). Allergen content of  best-selling ethnic versus nonethnic shampoos, conditioners, and styling products. Dermatitis 2021;32(2):101–110 https://donovanmedical.com/diy   PREMATURE GREYING (EARLY CANITIES) Anggraini et al (starts at 1:08:50). Risk Factors Associated with Premature Hair Greying of Young Adult. Open Access Maced J Med Sci . 2019 Nov 14;7(22):3762-3764. Dawber RP (starts at 1:09:12). Integumentary associations of pernicious anaemia. Br J Dermatol . 1970 Mar;82(3):221-3. Mosley JG and Gibbs AC (starts at 1:09:50). Premature grey hair and hair loss among smokers: a new opportunity for health education? British Medical Journal 1996; 313: 1616. Bhat RM et al (starts at 1:10:21). Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Int J Trichology. 2013;5:17–21. Chang H-C and Sung C-W (starts at 1:10:35). Association between serum levels of minerals and premature hair graying: a systematic review and meta-analysis. Int J Dermatol. 2020 Oct;59(10):e378-e380. Schnohr P et al (starts at 1:12:35). Longevity and gray hair, baldness, facial wrinkles, and arcus senilis in 13,000 men and women: The Copenhagen city heart study. J Gerontol A Biol Sci Med Sci. 1998;53:M347–50. Schnohr P et al. Gray hair, baldness, and wrinkles in relation to myocardial infarction: the Copenhagen City Heart Study. Am Heart J  1995 Nov;130(5):1003-10.   Kocaman SA et al (starts at 1:14:10) . The degree of premature hair graying as an independent risk marker for coronary artery disease: A predictor of biological age rather than chronological age. Anadolu Kardiyol Derg 2012;12:457-63.  Paik S et al (starts at 1:14:25). Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-sectional Study. Acta Derm Venereo. 2018 Aug 29;98(8):748-752. Mahendiratta S et al (starts at 1:15:09). Premature graying of hair: Risk factors, co-morbid conditions, pharmacotherapy and reversal-A systematic review and meta-analysis. Dermatol Ther. 2020 Nov;33(6):e13990. Das S et al (starts at 1:15:51) Cardiovascular risk markers in premature canities. Indian J Dermatol Venereol Leprol. 2022 Jun 30;1-5.

Decreasing stress, gaining concentration, and vitamin D are just a few simple ways you can benefit from getting outside more often. Health is complicated, but getting outside is an easy, free way you can benefit your health. Learn about grounding, forest bathing, and your circadian rhythm, and all the health advantages that come from the great outdoors.  Take a look at the thermal images from grounding in this academic journal, Explore! https://doi.org/10.1016/j.explore.2019.10.005  Other References: Menigoz W, Latz TT, Ely RA, Kamei C, Melvin G, Sinatra D. Integrative and lifestyle medicine strategies should include Earthing (grounding): Review of research evidence and clinical observations. Explore (NY). 2020 May-Jun;16(3):152-160. doi: 10.1016/j.explore.2019.10.005. Epub 2019 Nov 14. PMID: 31831261. https://doi.org/10.1016/j.explore.2019.10.005 Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019 Jun;60(3):237-244. doi: 10.1016/j.pedneo.2019.04.007. Epub 2019 Apr 17. PMID: 31101452.https://www.pediatr-neonatol.com/article/S1875-9572(18)30651-X/fulltext Li Q. Effect of forest bathing trips on human immune function. Environ Health Prev Med. 2010 Jan;15(1):9-17. doi: 10.1007/s12199-008-0068-3. PMID: 19568839; PMCID: PMC2793341. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793341/  --- Support this podcast: https://anchor.fm/liv-whisler/support

This is the audio-only version of a Zoom discussion panel about the 2022 Hugo nominees for Best Short Story. It's slightly shorter than the video, which you can find here: https://www.youtube.com/watch?v=cfmZaNdsflo Time Codes: Mr Death: 6:25 Proof by Induction: 20:31 The Sin of America: 43:22 Tangles: 58:12 Unknown Number: 1:12:33 Where Oaken Hearts Do Gather: 1:26:37 Story Links: “Mr. Death” by Alix E. Harrow (Apex Magazine, Feb 2021) https://apex-magazine.com/short-fiction/mr-death/ “Proof by Induction” by José Pablo Iriarte (Uncanny Magazine, May/Jun 2021) https://www.uncannymagazine.com/article/proof-by-induction/ “The Sin of America” by Catherynne M. Valente (Uncanny Magazine, Mar/Apr 2021) https://www.uncannymagazine.com/article/the-sin-of-america/ “Tangles” by Seanan McGuire (Magicthegathering.com: Magic Story, Sep 2021) https://magic.wizards.com/en/articles/archive/magic-story/tangles-2021-09-03 “Unknown Number” by Blue Neustifter (Twitter, Jul 2021) https://twitter.com/Azure_Husky/status/1420177932518137862 “Where Oaken Hearts Do Gather” by Sarah Pinsker (Uncanny Magazine, Mar/Apr 2021) https://www.uncannymagazine.com/article/where-oaken-hearts-do-gather/ Panelists: Ann Spangler (https://twitter.com/NebulaHugo) Rob Tomshany (https://twitter.com/RobTomshany) Amanda Wakaruk (https://twitter.com/Hugo_Book_Club) Lisa McCarty (https://twitter.com/lisa_jm) JW Wartick (https://twitter.com/jwwartick) Ivor Watkins Cora Buhlert https://twitter.com/corabuhlert) Lori Anderson & Haley Zapal (https://twitter.com/hugogirlpodcast) Sarah Elkins (https://twitter.com/ConFigures) Juan Sanmiguel (https://twitter.com/RainbowWar71)

Kavadya T and Mysore V (starts at 5:24). Role of Smoking in Androgenetic Alopecia: A Systematic Review. Int J Trichology. 2022 Mar-Apr; 14(2): 41–48.   Mosley JG and Gibbs AC (starts at 6;30). Premature grey hair and hair loss among smokers: a new opportunity for heatlh education? British Medical Journal 1996; 313: 1616.   Su LH and Chen T H-H (starts at 7:38) Association of Androgenetic Alopecia with Smoking and Its Prevalence Among Asian Men. Archives of Dermatology 2007 143; 1401-1406.       Calvao J et al (starts at 9:16). Finasteride and Floppy Iris Syndrome: What Role Can the Dermatologist Play? Int J Trichology. May-Jun 2022;14(3):115-116.   Ting H-C et al (starts at 14:04). Association between alopecia areata and retinal diseases: A nationwide population-based cohort study. J Am Acad Dermatol . 2021 Nov 1;S0190-9622(21)02735-3.   Thatiparthi A et al (starts at 15:56). Inflammatory ocular comorbidities in alopecia areata: a retrospective cohort study of a single academic center. J Am Acad Dermatol. 2022 Jun 16;S0190-9622(22)01009-X     Albela H et al (starts at 19:32). Efficacy and Tolerability of Methotrexate in the Treatment of Severe Paediatric Alopecia Areata. Skin Appendage Disord. 2022 May;8(3):206-210.     Barton V et al (starts at 24:20). Treatment of pediatric alopecia areata: A systematic review. J Am Acad Dermatol. 2022 Jun;86(6):1318-1334.     Gambardella A, et al (starts at 29:18). Dual Efficacy of Upadacitinib in 2 Patients With Concomitant Severe Atopic Dermatitis and Alopecia Areata. Dermatitis 2021; 32: e85–e86.   Cantelli M et al (starts at 31:35). Upadacitinib improved alopecia areata in a patient with atopic dermatitis: a case report. Dermatol Ther. 2022; 1: e15346    Asfour et al (starts at 32:35). Concurrent chronic alopecia areata and severe atopic dermatitis successfully treated with upadacitinib.  Int J Dermatol. 2022 Jun 20.   Gori N et al (starts at 33:53). Assessment of alopecia areata universalis successfully treated with upadacitinib. Int J Dermatol. 2022 Jul 2.     Conclusions and Summary (starts at 37:24)

This episode we discuss some of the big events happening in the world during May/Jun 2022, well... the ones that piqued our interests such as the Depp vs Heard trial, reboots coming our way, the Marvel Cineverse and much more! I think... #2ndbottlenojudgement

Pablo (@Ian_Fleming) presenta con David (@007_David_Acín), Agustín (@Weyland_Yutani1975) y Ramón (@El_Santo) un podcast con todas nuestras secciones y un debate sobre la evolución del personaje de James Bond a lo largo de la historia: 00:00:00 – 00:02:10 Introducción al podcast 00:02:11 – 00:03:33 Presentación 007_David_Acin 00:03:34 – 00:10:28 Opiniones de los oyentes 00:10:29 – 00:36:30 Noticias del mes 00:36:31 – 00:38:32 Efemérides Bond 00:38:33 – 00:39:49 Promo Ian Fleming y James Bond: Conexión España 00:39:50 – 02:28:51 Debate La evolución de James Bond con Weyland_Yutani1975 y El_Santo 02:28:52 – 02:29:29 Promo Taller Skywalker 02:29:30 – 02:30:00 Promo Club Archivo 007 02:30:01 – 02:34:13 Despedida 02:34:14 – 02:35:22 Canción final

Drs. Tom Dilworth and Stephanie Shealy May (@stephshealymay) join Dr. Rachel Britt (@RachelBPharmD) in the first episode of Breakpoints Dosing Consults to discuss questions and debates around ceftriaxone dosing. When should we use 1g over 2g? How does critical illness affect what dose to use? Is ceftriaxone the most approachable antibiotic? Tune in for answers to these questions and more!   Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/ References Ettestad PJ, Campbell GL, Welbel SF, Genese CA, Spitalny KC, Marchetti CM, Dennis DT. Biliary complications in the treatment of unsubstantiated Lyme disease. J Infect Dis. 1995 Feb;171(2):356-61. doi: 10.1093/infdis/171.2.356. PMID: 7844372. Hasegawa S, Sada R, Yaegashi M, Morimoto K, Mori T; Adult Pneumonia Study Group-Japan. 1g versus 2 g daily intravenous ceftriaxone in the treatment of community onset pneumonia - a propensity score analysis of data from a Japanese multicenter registry. BMC Infect Dis. 2019 Dec 26;19(1):1079. doi: 10.1186/s12879-019-4552-8. PMID: 31878894; PMCID: PMC6933656. Barber KE, Loper JT, Morrison AR, Stover KR, Wagner JL. Impact of Obesity on Ceftriaxone Efficacy. Diseases. 2020 Jul 9;8(3):27. doi: 10.3390/diseases8030027. PMID: 32660113; PMCID: PMC7563366. Herrera-Hidalgo L, de Alarcón A, López-Cortes LE, Luque-Márquez R, López-Cortes LF, Gutiérrez-Valencia A, Gil-Navarro MV. Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for Enterococcus faecalis Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs? Antimicrob Agents Chemother. 2020 Dec 16;65(1):e02099-20. doi: 10.1128/AAC.02099-20. Erratum in: Antimicrob Agents Chemother. 2021 May 18;65(6): PMID: 33046488; PMCID: PMC7927845. Herrera-Hidalgo L, Lomas-Cabezas JM, López-Cortés LE, Luque-Márquez R, López-Cortés LF, Martínez-Marcos FJ, de la Torre-Lima J, Plata-Ciézar A, Hidalgo-Tenorio C, García-López MV, Vinuesa D, Gutiérrez-Valencia A, Gil-Navarro MV, De Alarcón A. Ampicillin Plus Ceftriaxone Combined Therapy for Enterococcus faecalis Infective Endocarditis in OPAT. J Clin Med. 2021 Dec 21;11(1):7. doi: 10.3390/jcm11010007. PMID: 35011748; PMCID: PMC8745305. Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, Reno H, Zenilman JM, Bolan GA. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. doi: 10.15585/mmwr.rr7004a1. PMID: 34292926; PMCID: PMC8344968. Whittles LK, White PJ, Paul J, Didelot X. Epidemiological Trends of Antibiotic Resistant Gonorrhoea in the United Kingdom. Antibiotics (Basel). 2018 Jul 13;7(3):60. doi: 10.3390/antibiotics7030060. PMID: 30011825; PMCID: PMC6165062. Ackerman A, Zook NR, Siegrist JF, Brummitt CF, Cook MM, Dilworth TJ. Comparison of Clinical Outcomes among Intensive Care Unit Patients Receiving One or Two Grams of Ceftriaxone Daily. Antimicrob Agents Chemother. 2020 May 21;64(6):e00066-20. doi: 10.1128/AAC.00066-20. PMID: 32205348; PMCID: PMC7269488. Ulldemolins M, Roberts JA, Rello J, Paterson DL, Lipman J. The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients. Clin Pharmacokinet. 2011 Feb;50(2):99-110. doi: 10.2165/11539220-000000000-00000. PMID: 21142293. Dailly E, Arnould JF, Fraissinet F, Naux E, Letard de la Bouralière MA, Bouquié R, Deslandes G, Jolliet P, Le Floch R. Pharmacokinetics of ertapenem in burns patients. Int J Antimicrob Agents. 2013 Jul;42(1):48-52. doi: 10.1016/j.ijantimicag.2013.02.021. Epub 2013 Apr 8. PMID: 23578794. Pai MP. Treatment of bacterial infections in obese adult patients: how to appropriately manage antimicrobial dosage. Curr Opin Pharmacol. 2015 Oct;24:12-7. doi: 10.1016/j.coph.2015.06.004. Epub 2015 Jun 25. PMID: 26119488. Mahmood I. Theoretical versus empirical allometry: Facts behind theories and application to pharmacokinetics. J Pharm Sci. 2010 Jul;99(7):2927-33. doi: 10.1002/jps.22073. PMID: 20127826. Kang N, Housman ST, Nicolau DP. Assessing the Surrogate Susceptibility of Oxacillin and Cefoxitin for Commonly Utilized Parenteral Agents against Methicillin-Susceptible Staphylococcus aureus: Focus on Ceftriaxone Discordance between Predictive Susceptibility and in Vivo Exposures. Pathogens. 2015 Jul 30;4(3):599-605. doi: 10.3390/pathogens4030599. PMID: 26264030; PMCID: PMC4584275. Gern BH, Greninger AL, Weissman SJ, Stapp JR, Tao Y, Qin X. Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus. Ann Clin Microbiol Antimicrob. 2018 Feb 20;17(1):5. doi: 10.1186/s12941-018-0257-x. PMID: 29463249; PMCID: PMC5819674. Bremmer DN, Balada-Llasat JM, Goff DA, Bauer KA. Ceftriaxone Etest non-susceptible methicillin susceptible Staphylococcus aureus time-kill responses. Diagn Microbiol Infect Dis. 2017 Jun;88(2):192-194. doi: 10.1016/j.diagmicrobio.2017.02.019. Epub 2017 Mar 2. PMID: 28291629. Kosowska-Shick K, McGhee PL, Appelbaum PC. Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother. 2010 May;54(5):1670-7. doi: 10.1128/AAC.00019-10. Epub 2010 Mar 1. PMID: 20194704; PMCID: PMC2863635. Palmer SM, Kang SL, Cappelletty DM, Rybak MJ. Bactericidal killing activities of cefepime, ceftazidime, cefotaxime, and ceftriaxone against Staphylococcus aureus and beta-lactamase-producing strains of Enterobacter aerogenes and Klebsiella pneumoniae in an in vitro infection model. Antimicrob Agents Chemother. 1995 Aug;39(8):1764-71. doi: 10.1128/AAC.39.8.1764. PMID: 7486916; PMCID: PMC162823. Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):89-96. doi: 10.1016/0732-8893(95)00053-d. PMID: 7587056. Garot D, Respaud R, Lanotte P, Simon N, Mercier E, Ehrmann S, Perrotin D, Dequin PF, Le Guellec C. Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal. Br J Clin Pharmacol. 2011 Nov;72(5):758-67. doi: 10.1111/j.1365-2125.2011.04005.x. PMID: 21545483; PMCID: PMC3243010. Joynt GM, Lipman J, Gomersall CD, Young RJ, Wong EL, Gin T. The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients. J Antimicrob Chemother. 2001 Apr;47(4):421-9. doi: 10.1093/jac/47.4.421. PMID: 11266414. Van Wart SA et al., ICAAC 2009, poster # A1-010 Housman ST, Sutherland CA, Nicolau DP. Pharmacodynamic profile of commonly utilised parenteral therapies against meticillin-susceptible and meticillin-resistant Staphylococcus aureus collected from US hospitals. Int J Antimicrob Agents. 2014 Sep;44(3):235-41. doi: 10.1016/j.ijantimicag.2014.05.012. Epub 2014 Jun 24. PMID: 25052866. Zelenitsky SA, Beahm NP, Iacovides H, Ariano RE, Zhanel G. Limitations of ceftriaxone compared with cefazolin against MSSA: an integrated pharmacodynamic analysis. J Antimicrob Chemother. 2018 Jul 1;73(7):1888-1894. doi: 10.1093/jac/dky120. PMID: 29635472. Paul M, Zemer-Wassercug N, Talker O, Lishtzinsky Y, Lev B, Samra Z, Leibovici L, Bishara J. Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia? Clin Microbiol Infect. 2011 Oct;17(10):1581-6. doi: 10.1111/j.1469-0691.2010.03425.x. Epub 2010 Dec 14. PMID: 21073629. Carr DR, Stiefel U, Bonomo RA, Burant CJ, Sims SV. A Comparison of Cefazolin Versus Ceftriaxone for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia in a Tertiary Care VA Medical Center. Open Forum Infect Dis. 2018 May 18;5(5):ofy089. doi: 10.1093/ofid/ofy089. PMID: 30568987; PMCID: PMC5961173. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints.

NASH occurs in around 20% of individuals with NAFLD, and puts patients at high risk of poor outcomes including cardiovascular events and hepatocellular carcinoma. With people with type 2 diabetes and obesity at significantly increased risk for developing NAFLD, how can we identify those with NASH? In this podcast episode, we are joined by Dr Kenneth Cusi to discuss how patients can be risk stratified using non-invasive biomarkers and imaging techniques. By completing this activity you can qualify for 0.25 CME credits. To claim your credits, you must listen to the podcast and successfully pass the post-module assessment at diabetes.knowledgeintopractice.com, where you can find all past episodes of the podcast as well as other free CME resources. References: Nones RB et al. Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? Arch Endocrinol Metab. 2017 May-Jun;61(3):276-281. Shah AG et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009 Oct;7(10):1104-12. Newsome PN et al. FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study. Lancet Gastroenterol Hepatol. 2020 Apr;5(4):362-373. European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obes Facts 2016;9(2):65-90. Disclosures: Dr Kenneth Cusi disclosures are as follows: Research Support - Poxel, Zydus, Echosens, Inventiva, Novo Nordisk Consultant - Allergan, Altimmune, Arrowhead, AstraZeneca, BMS, Boehringer Ingelheim, Coherus, Eli Lilly, Genentech, Gilead, Intercept, Janssen, Pfizer, Prosciento, Madrigal, and Novo Nordisk. Liberum IME staff, ACHL staff and others involved with the planning, development, and review of the content for this activity have no relevant affiliations or financial relationships to disclose. The Academy for Continued Healthcare Learning (ACHL) requires that the faculty participating in an accredited continuing education activity disclose all affiliations or other financial relationships (1) with the manufacturers of any commercial product(s) and/or provider(s) of commercial services discussed in an educational presentation and (2) with any commercial supporters of the activity. All conflicts of interest have been mitigated prior to this activity. Funding: This independent educational activity is supported by an educational grant from Novo Nordisk A/S. The educational content has been developed by Liberum IME in conjunction with an independent steering committee; Novo Nordisk A/S has had no influence on the content of this education.

In this episode, I explain anosmia and what you can do to aid in recovery. This episode is sponsored by McNeese Construction. Check out our store at www.se7en.surf where you will find cool items for you, your family, and your pets. To keep this podcast going please feel free to donate at www.paypal.me/yopistudio If you would like to read more on this topic or any other previous topics, you can do so by checking out our blog at https://yopistudio.blogspot.com/ Feel free to see what we are up to by following us at:  https://twitter.com/Dauricee https://www.facebook.com/yopistudio/ https://www.facebook.com/LouisianaEntertainmentAssociation/ To listen to the podcast, watch creative videos and skits go to https://www.youtube.com/channel/UCvn6tns6wKUwz9xZw11_vAQ/videos Interested in projects Daurice has worked on in the movie industry you can check it out at www.IMDb.com under Daurice Cummings. For comments or questions, you can reach us at yopi@post.com To read more about today's topic check out the references below. References: [i] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [ii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [iii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [iv] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [v] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [vi] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [vii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [viii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [ix] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [x] Chem Senses. 2016 May; 41(4): 293-299. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5006107/ [xi] Int J Mol Sci. 2021 Aug 18;22(16):8912. doi: 10.3390/ijms22168912. https://pubmed.ncbi.nlm.nih.gov/34445619/ [xii] Rhinology 55: 17-26, 2017 https://www.rhinologyjournal.com/Rhinology_issues/manuscript_1517.pdf [xiii] Int J Mol Sci. 2021 Aug; 22(16): 8912. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8396277/ [xiv] Int J Mol Sci. 2021 Aug; 22(16): 8912. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8396277/ [xv] Laryngoscope. 2002 Nov;112(11):2076-80. PMID: 12439184 www.greenmedinfo.com/article/lipoic-acid-may-have-therapeutic-value-treating-smell-dysfunction-following-vi [xvi] Am J Rhinol. 2008 May-Jun;22(3):292-6. PMID: 18588762 www.greenmedinfo.com/article/ginkgo-biloba-may-contribute-restoring-olfactory-loss [xvii] Arch Otolaryngol Head Neck Surg. 2009;135(10):1000-1004. doi:10.1001/archoto.2009.141 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/410599 [xviii] Avicenna J Phytomed. 2022 Jan-Feb; 12(1): 1-7. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8801216/ [xix] Laryngoscope Investigative Otolaryngology December 25, 2020 https://onlinelibrary.wiley.com/doi/full/10.1002/lio2.513 [xx] Otolaryngol Head Neck Surg. 2015 May;152(5):954-8. doi: 10.1177/0194599815571272. Epub 2015 Feb 24. https://pubmed.ncbi.nlm.nih.gov/25715353/ [xxi] Cureus 13(9): e17829. doi:10.7759/cureus.17829 https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia  

Beth underwent gender transition from natal female to trans male and has since de-transitioned. In her early teens, Beth felt she was not like other women and began to question her gender. She saw people who were nonconforming, but although she adopted a non-binary identity in college, people still saw her as a woman. Beth became drawn to a masculine identity and associated transitioning gender with empowerment: she would be free from the perceived social constraints and physical vulnerabilities of womanhood. Beth's parents, the therapist she saw a few times, and the surgeon all affirmed her desire to transition. Beth underwent testosterone therapy and top surgery to remove her breasts, sacrifices in service of liberation. In time, however, Beth discovered that physical changes did not transform her inner world, and her post-surgical chest remains numb. Beth says, “de-transitioning brought me down to earth” and into adulthood. She feels some of her urges to transition were healthy, and some were self-annihilating—and wishes she had had more help in differentiating her inner world from her gender expression. Beth hopes to be a voice for the complexity of gender transitioning. Here's Beth's dream: “I met a woman in a lush forest. The forest was filled with strange relics—an abandoned child's playground, a little home, and abandoned campsites. I knew she was a detransitioner, but unlike me, she was proud, unabashed, and free. She told me I could be free like her once no one knew where to find me. Then she ran off into the jungle. There was an exhilarating feeling of freedom and hope.”   BEYOND THE BREAKING POINT Music and lyrics by Wells Hanley ©2021You were my lost loverI tried for so longjust to find you here beside meI was so wrongI wandered darkened highwaysI turned every stonefar beyond the point of breakingbut I was never aloneSo afraid I would die waitingHow I hoped you would be thereand that you'd find meout beyond the breaking point So I swam in shark filled watersI swam in despairMy flesh was eaten, bruised, and beatenMy blood was spilled everywhereAnd as I sank down to the bottomand my life began to fade,you opened up your eyesout beyond the breaking point And as we gaze into the heavenswhere we dwell among the trees,you're always with me here beyond the breaking point _____________ Music and lyrics by Wells Hanley ©2021 Singers: Laura Ann Singh at www.lauraannsingh.com and Rei Alvarez at www.reialvarez.com https://www.iwrotethissongforyou.com/ https://www.patreon.com/iwrotethissongforyou NOTES:  Currently, there is limited research on the factors that correlate with detransition and the percentage of individuals who chose to detransition. Of the available studies, methods and definitions vary, suggesting a need to establish standardized criteria in the future. Five studies are mentioned below. One concludes, of 17,151 who identify as transgender and gender diverse people, 13.1% reported a history of detransition or going back to living as their sex assigned at birth. Another concludes that only 0.2-0.3% of patients expressed post-operative regret and requested reversal surgery. In another study, 6.9% of patients detransitioned. Additional research is necessary to understand these phenomena more fully.  Boyd, I.; Hackett, T.; Bewley, S. Care of Transgender Patients: A General Practice Quality  Improvement Approach. Healthcare 2022, 10, 121. https://doi.org/10.3390/healthcare100 10121 Hall, R., Mitchell, L., & Sachdeva, J. (2021). Access to care and frequency of detransition among a cohort discharged by a UK national adult gender identity clinic: Retrospective case-note review. BJPsych Open, 7(6), E184. doi:10.1192/bjo.2021.1022 Littman L. Individuals Treated for Gender Dysphoria with Medical and/or Surgical Transition Who Subsequently Detransitioned: A Survey of 100 Detransitioners. Arch Sex Behav. 2021 Nov;50(8):3353-3369. doi: 10.1007/s10508-021-02163-w. Epub 2021 Oct 19. PMID: 34665380; PMCID: PMC8604821. Narayan SK, Hontscharuk R, Danker S, Guerriero J, Carter A, Blasdel G, Bluebond-Langner R, Ettner R,  Radix A, Schechter L, Berli JU. Guiding the conversation - types of regret after gender-affirming surgery and their associated etiologies. Ann Transl Med 2021;9(7):605. doi: 10.21037/atm-20-6204. Turban JL, Loo SS, Almazan AN, Keuroghlian AS. Factors Leading to “Detransition” Among Transgender and Gender Diverse People in the United States: A Mixed-Methods Analysis. LGBT Health. 2021 May-Jun;8(4):273-280. doi: 10.1089/lgbt.2020.0437. Epub 2021 Mar 31. PMID: 33794108; PMCID: PMC8213007. GIVE US A HAND! Become our patron: https://www.patreon.com/ThisJungianLife RESOURCES: Learn to Analyze your own Dreams: https://thisjungianlife.com/enroll/

In this Episode, Zach and Alex discuss trauma and new research surrounding injuries in the United States. Enjoy! Articles:1. Pino EC, Gebo E, Dugan E, Jay J. Trends in Violent Penetrating Injuries During the First Year of the COVID-19 Pandemic. JAMA Netw Open. 2022;5(2):e2145708. doi:10.1001/jamanetworkopen.2021.457082. Fu CY, Bajani F, Bokhari M, Butler C, Starr F, Messer T, Kaminsky M, Tatebe LC, Dennis A, Schlanser V, Poulakidas S, Cheng CT, Toor R, Mis J, Bokhari F. Obesity May Require a Higher Level of Trauma Care: A Propensity-Matched Nationwide Cohort Study. Prehosp Emerg Care. 2021 May-Jun;25(3):361-369. doi: 10.1080/10903127.2020.1755754. Epub 2020 May 5. PMID: 32286928.3. Morgan MM, Perina DG, Acquisto NM, Fallat ME, Gallagher JM, Brown KM, Ho J, Burnett A, Lairet J, Rowe D, Gestring ML. Ketamine Use in Prehospital and Hospital Treatment of the Acute Trauma Patient: A Joint Position Statement. Prehosp Emerg Care. 2021 Jul-Aug;25(4):588-592. doi: 10.1080/10903127.2020.1801920. Epub 2020 Aug 27. PMID: 32776812.Article Link: Ketamine Use in Prehospital and Hospital Treatment of the Acute Trauma Patient: A Joint Position Statement (tandfonline.com)4. Robinson EJ, Watanabe BL, Brown LH. Ketamine for Prehospital Pain Management Does Not Prolong Emergency Department Length of Stay. Prehosp Emerg Care. 2021 Nov-Dec;25(6):753-760. doi: 10.1080/10903127.2020.1819493. Epub 2020 Oct 12. PMID: 32886533.––––––––––––––––––––––––––––––Track: Rainy Paradise — Next Route & WOMA [Audio Library Release]Music provided by Audio Library PlusWatch: https://youtu.be/i8JM7pzhRnwFree Download / Stream: https://alplus.io/rainy-paradise––––––––––––––––––––––––––––––Intro Provided by Mn Native and Voice Actor Brady LaRock

每日英語跟讀 Ep.K107: ‘My Turn to Get Robbed': Delivery Workers Are Targets in the Pandemic   The delivery of restaurant orders and other goods has become a bigger part of daily life across the nation since the pandemic forced millions of people indoors. And in New York City the delivery workers have become a lifeline for people working from home and for vulnerable residents who have been warned against going outside. 自從新冠肺炎疫情迫使數以百萬計的人待在室內後，餐點等商品的外送服務在全美人民的日常生活中，分量變得更重了。而在紐約，對於在家工作者和被警告別外出的高風險居民而言，快遞員更成了他們的救生索。 On any given day thousands of men, and a growing number of women, can be seen crisscrossing city arteries, transporting takeout, groceries and medicine in plastic bags on top of their well-worn bikes. 每一天，數以千計男性和愈來愈多的女性騎著已經不新的電動自行車在紐約幹道上穿梭，把裝在塑膠袋裡的外送餐點、食品雜貨和藥品送到收貨人手中。 But their visibility has also made them targets for opportunistic criminals looking for a quick profit through robbery, as the unemployment rate has spiked into the double digits and economic desperation has grown in the city's less affluent neighborhoods, which were already hit hard by the pandemic. 不過，隨著紐約較不富裕的地區受到疫情重創，失業率飆升到兩位數，人們需錢孔急，處處可見的快遞員便成了想靠搶劫快速得到錢的投機罪犯鎖定的目標。 Stolen electric bikes can be easily sold on the streets for cash or dismantled for their parts. The bikes can cost thousands of dollars and are vital tools for the workers, who often make less than $60 a day. Many have come to rely on the bikes, because they can go about 20 mph, enabling workers to travel farther and make more trips to increase their slim bottom lines. 偷來的電動自行車很容易在街上轉賣或拆零件變賣。新的電動自行車售價可能高達幾千美元，而且對一天經常賺不到60美元的快遞員來說不可或缺。許多快遞員依賴電動自行車，因為這種車時速能達到32公里，讓快遞員能送貨到更遠處，並接更多單以增加微薄的收入。 The theft of electric bikes doubled during the first year of the pandemic, rising to 328 in 2020. 在疫情流行的第一年，也就是2020年，電動自行車竊案翻倍至328起。 Investigators said robbers often use fraudulent credit cards to call in bogus orders and lure delivery workers to secluded locations. The delivery workers then are faced with two dire options: let go of the pricey bikes they need to remain employed or risk injury and even death. 辦案人員說，搶劫者常常用偽造或偷來的信用卡下個假訂單，把快遞員引到偏僻處下手，快遞員接著會面臨兩個極端選擇，不是放棄賴以工作的昂貴電動自行車，就是冒著受傷甚至死亡的風險把自行車追回來。 “We believe more often than not it is a setup,” said Rodney Harrison, the New York Police Department's chief of department. 紐約市警察局總警監哈里森說：「我們認為這通常是設下的圈套。」 The northern section of Manhattan, Southern Brooklyn and the Bronx have seen the biggest spikes in robberies, investigators said. Most of the victims were threatened with sharp objects, guns and other weapons. 辦案人員指出，曼哈頓北部、布魯克林南部和布朗克斯的搶劫案增加最多。嫌犯多半拿銳器、槍枝等武器威脅受害者。 There were about 50,000 commercial cyclists in New York in 2012, the most recent year for which data is available, city transportation officials said. That figure has since soared, by some activists' estimates, to about 80,000. 紐約市運輸官員說，根據既有最晚近的資料，2012年紐約有5萬人騎自行車送貨。一些社運人士估計，此後這個數字暴增到8萬左右。 In October, more than 1,000 protesters joined a demonstration outside City Hall organized by a collective known as Los Deliveristas Unidos to call attention to the robberies and other poor working conditions, including low pay, a shortage of protective gear, and a lack of places to rest or use a restroom. 去年10月，1000多人在紐約市政廳外參加「快遞員聯合會」的抗議，要求大眾關注快遞員易遭搶劫等惡劣的工作條件，包括低薪、防護裝備不足、缺乏休息處和洗手間等。Source article: https://udn.com/news/story/6904/5332541   每日英語跟讀Podcast，就在http://www.15mins.today/daily-shadowing 每週Vocab精選詞彙Podcast，就在https://www.15mins.today/vocab 每週In-TENSE文法練習Podcast，就在https://www.15mins.today/in-tense 用email訂閱就可以收到通勤學英語節目更新通知。

Benger JR, Kirby K, Black S, Brett SJ, Clout M, Lazaroo MJ, Nolan JP, Reeves BC, Robinson M, Scott LJ, Smartt H, South A, Stokes EA, Taylor J, Thomas M, Voss S, Wordsworth S, Rogers CA. Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial. JAMA. 2018 Aug 28;320(8):779-791. doi: 10.1001/jama.2018.11597. PMID: 30167701; PMCID: PMC6142999. Bernhard M, Becker TK, Gries A, Knapp J, Wenzel V. The First Shot Is Often the Best Shot: First-Pass Intubation Success in Emergency Airway Management. Anesth Analg. 2015 Nov;121(5):1389-93. doi: 10.1213/ANE.0000000000000891. PMID: 26484464. Culbreth RE, Gardenhire DS. Manual bag valve mask ventilation performance among respiratory therapists. Heart Lung. 2021 May-Jun;50(3):471-475. doi: 10.1016/j.hrtlng.2020.10.012. Epub 2020 Nov 1. PMID: 33138977; PMCID: PMC7604178. Ioannidis JP. Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?. Philos Ethics Humanit Med. 2008;3:14. Published 2008 May 27. doi:10.1186/1747-5341-3-14 Sackles, et. al. (2013). The importance of first pass success when performing orotracheal intubation in the ED. Acad Emerg Med, 20(1). Wang HE, Schmicker RH, Daya MR, Stephens SW, Idris AH, Carlson JN, Colella MR, Herren H, Hansen M, Richmond NJ, Puyana JCJ, Aufderheide TP, Gray RE, Gray PC, Verkest M, Owens PC, Brienza AM, Sternig KJ, May SJ, Sopko GR, Weisfeldt ML, Nichol G. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2018 Aug 28;320(8):769-778. doi: 10.1001/jama.2018.7044. PMID: 30167699; PMCID: PMC6583103. This podcast is hosted by ZenCast.fm

In this episode, we talk about ketamine and how we have been using it in our department. Our experiences, some anecdotes, some evidence. We are not endorsing that you HAVE to use ketamine, but enlightening you that it can be used and the dogmas regarding it being unsafe are exactly those - DOGMAS. Following are the papers that you may read as references. They will guide you more about ketamine. Hope you enjoy the episode!. Have a Happy New Year! Reading material - 1. Domino EF, Chodoff P, Corssen G. Pharmacologic effects of CI-581, A new dissociative anesthetic, in man. Clin Pharmacol Ther. 1965 May-Jun;6:279-91. doi: 10.1002/cpt196563279. PMID: 14296024. 2. Godwin SA, Burton JH, Gerardo CJ, Hatten BW, Mace SE, Silvers SM, Fesmire FM; American College of Emergency Physicians. Clinical policy: procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2014 Feb;63(2):247-58.e18. doi: 10.1016/j.annemergmed.2013.10.015. Erratum in: Ann Emerg Med. 2017 Nov;70(5):758. PMID: 24438649. 3. Kiureghian E, Kowalski JM. Intravenous ketamine to facilitate noninvasive ventilation in a patient with a severe asthma exacerbation. Am J Emerg Med. 2015 Nov;33(11):1720.e1-2. doi: 10.1016/j.ajem.2015.03.066. Epub 2015 Apr 7. PMID: 25895715. 4. Green SM, Roback MG, Kennedy RM, Krauss B. Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update. Ann Emerg Med. 2011 May;57(5):449-61. doi: 10.1016/j.annemergmed.2010.11.030. Epub 2011 Jan 21. PMID: 21256625. 5. Godoy DA, Badenes R, Pelosi P, Robba C. Ketamine in acute phase of severe traumatic brain injury "an old drug for new uses?". Crit Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x. PMID: 33407737; PMCID: PMC7788834. 6. Cohen L, Athaide V, Wickham ME, Doyle-Waters MM, Rose NG, Hohl CM. The effect of ketamine on intracranial and cerebral perfusion pressure and health outcomes: a systematic review. Ann Emerg Med. 2015 Jan;65(1):43-51.e2. doi: 10.1016/j.annemergmed.2014.06.018. Epub 2014 Jul 23. PMID: 25064742. 7. Verma A, Snehy A, Vishen A, Sheikh WR, Haldar M, Jaiswal S. Ketamine Use allows Noninvasive Ventilation in Distressed Patients with Acute Decompensated Heart Failure. Indian J Crit Care Med. 2019 Apr;23(4):191-192. doi: 10.5005/jp-journals-10071-23153. PMID: 31130793; PMCID: PMC6521817. 8. Shaprio HM, Wyte SR, Harris AB. Ketamine anaesthesia in patients with intracranial pathology. Br J Anaesth. 1972 Nov;44(11):1200-4. doi: 10.1093/bja/44.11.1200. PMID: 4647115. 9. Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS. Delayed sequence intubation: a prospective observational study. Ann Emerg Med. 2015 Apr;65(4):349-55. doi: 10.1016/j.annemergmed.2014.09.025. Epub 2014 Oct 23. PMID: 25447559.

Dr. George C Fareed is a Harvard trained medical doctor who started out working in virology with Dr. Fauci at the National Institutes of Health, National Institute of Allergy and Infectious Diseases early in his career. Then Dr. Fareed wanted to help the “underserved” . Thus, Dr. Fareed moved from Washington to east of San Diego. This is a highly agricultural area. These people are mainly of Hispanic descent with high incidence of health issues that often make them much more vulnerable to severe viral disease. In this population, Dr. Fareed recently has treated over 7,000 cases of this virus . In this highly vulnerable agricultural population that has high incidences of type 2 Diabetes, high blood pressure and metabolic syndrome. Remember, these are the very “co-morbidities” that increase the risk of severe reactions to the pandemic. Dr. Fareed utilized “early intervention”.  As described in the article just published by himself and a number of esteemed medical colleagues below. The national average right now, with the Delta variant, if you get the virus and get so ill you have to be hospitalized, is a rate called “hospitalization rate”. It depends on age. But the national average of being treated the typical manner, translated into 9% hospitalization rate if you are over 60 years of age. And if you are under 50 years old , the hospitalization rate s 0.4%. Dr. Fareed's office had a statistician come in and track the efficacy of his protocol. This was done on the first 4,500 patients. Their rate of how many of Dr. Fareed's patients proceeded to get a severe case and require hospitalization was only 0.07%. But Dr. Fareed's, on his patients with extreme vulnerabilities, has been statistically proven to be less than a half of a percent. It is 0.07%. So… his protocols are keeping vulnerable patients out of hospitals. The question becomes, “Why is early intervention being censored? Not available? Doctors that talk and write about it, worried they might have to go before their medical board?” Dr. Fareed is leaving to go to the Rome Covid World Summits in a few weeks and will come back on the show to share what was discussed by viral experts around the world. Dr. Fareed has a book soon coming out talking about his journey in treatment of pandemic patients. Links: How Many SARS-CoV-2-Infected People Require Hospitalization? Using Random Sample Testing to Better Inform Preparedness Efforts. J Public Health Manag Pract. 2021 May-Jun 01;27(3):246-250. doi: 10.1097/PHH.0000000000001331. PMID: 33729203. Here is an article of how Dr. Fareed helps: Low Rates of Hospitalization and Death in 4,376 COVID-19 Patients Given Early Ambulatory Medical and Supportive Care. A Case Series and Observational Study. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) - PubMed (nih.gov) https://www.medrxiv.org/content/10.1101/2021.01.28.21250706v1.full-text  

UK Housing Market Update - July 2021⬇️ NMW 'Approved' Services: ⬇️

The ingredients in this supplement have been life changing for thousands of people. If you are looking for a way to help relieve your pain, improve your mobility, and decrease the amount of pain pills you are taking you have to check this out. Also, if you would like help improving your strength, balance, or range of motion you can setup a Breakthrough Exam HERE. Research Articles: 1. Int J Mol Sci. 2019 Sep 20; 20(17): 4101 2. Indian J Pharm Sci. 2011 May-Jun; 73(3): 255-261

It's Monday, so it's time for our NEW RELEASE MONDAYS podcast series. This edition we're focusing on Doom Metal where we spotlight new and upcoming releases in doom metal/rock, including stoner of course. This episode we look at May and June 2021 releases. We're all doomed! (0:00) BLACK FLARE - Black Flare https://www.facebook.com/blackflareband (5:06) HIGH N'HEAVY - V https://highnheavy.bandcamp.com/album/v (7:56) PARISH - God's Right Hand https://parishuk.bandcamp.com/album/gods-right-hand (12:33) RIFT GIANT - Cataclysm https://planetkrecords.bandcamp.com/track/rift-giant (17:48) 10,000 YEARS - II https://oldemagickrecords.bandcamp.com/album/10000-years-ii-cassette (21:56) OAK - Fin https://oakstoner.bandcamp.com/album/fin (27:52) HERMIT'S WEEDSOM - As Above So Below https://hermitsweedsom.bandcamp.com/ (35:57) GRIEF COLLECTOR - En Delirium https://griefcollectorpetrichor.bandcamp.com/album/en-delirium (40:29) MOTHMAN & THE THUNDERBIRDS - Into The Hallow https://mothmanandthethunderbirds.bandcamp.com/album/into-the-hollow

Presentado por Pablo (Ian_Fleming) y Javier (58), contamos en el debate con Ramón (El Santo) y todas estas secciones: 00:00:00 Presentación 00:01:36 Opiniones de los oyentes 00:04:35 Noticias del mes 00:33:35 Momento musical 00:38:46 Debate del mes con El Santo 03:06:00 Despedida

Welcome back to the 2nd week of Mirrorless Mission with yours truly. This week was when I began my navigation and adaption into what would be my new lifestyle for the next 6 weeks. As soon as my mind could no longer fixate on my flaws in the mirror, I directly began criticizing my body from my own point of view, which wasn't easy to stop. I decided to do a bit of research on the mind and why we criticize ourselves and incorporate social media and how that's affected us in the same ways a beauty pageant has. I hope you enjoy this weeks Mirrorless Mission podcast, tune in for next weeks episode where I will be adapting to the "hide-self view" feature on Zoom and what I've learned from that week. P.S. The report I mentioned that I would add: Wonderlich AL, Ackard DM, Henderson JB. Childhood beauty pageant contestants: associations with adult disordered eating and mental health. Eat Disord. 2005 May-Jun;13(3):291-301. doi: 10.1080/10640260590932896. PMID: 16864534. https://pubmed.ncbi.nlm.nih.gov/16864534/

Weight loss without dietary restriction: efficacy of different forms of aerobic exercise. Gwinup G. Am J Sports Med. 1987 May-Jun;15(3):275-9. doi: 10.1177/036354658701500317. PMID: 3618879 --- Send in a voice message: https://anchor.fm/moveman/message

Contributor: Katie Sprinkel, MD Educational Pearls: Commonly known as “acid,” LSD is seeing a resurgence in the population as a recreational hallucination Onset is about 30 minutes with peak pharmacologic effects at 2-4 hours, the drug’s half life is 3 hours resulting in some prolonged effects While there is not an significant addictive component of LSD, tolerance for LSD does occur and prolonged usage is associated with increased incidence of schizophreniform disorders Hallucinations and pseudo-hallucinations (sensory misperceptions) are typical of LSD intoxication, other common signs of intoxication include nausea, diaphoresis, tachycardia, mydriasis, and hypertension More serious effects can be coma, hyperthermia, seizures, cardiac arrest, serotonin syndrome (with concomitant SSRI use) and coagulopathy, although the dose to cause these effects is very high Treatment is decreasing sensory stimulation, benzodiazepines in some cases, and symptomatic treatment - no specific antidote exists References Blaho K, Merigian K, Winbery S, Geraci SA, Smartt C. Clinical pharmacology of lysergic acid diethylamide: case reports and review of the treatment of intoxication. Am J Ther. 1997 May-Jun;4(5-6):211-21. doi: 10.1097/00045391-199705000-00008. PMID: 10423613. Klock JC, Boerner U, Becker CE. Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med. 1974;120(3):183-188. Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD

**Correction** Bartonella was only detected in up to 30% of the cohort, not 50% as stated. Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233863/ Middelveen MJ, Cruz ID, Fesler MC, Stricker RB, Shah JS. Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques. Clin Cosmet Investig Dermatol. 2018;11:561-569. Published 2018 Nov 9. doi:10.2147/CCID.S184521 Epstein-Barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early Lyme borreliosis https://pubmed.ncbi.nlm.nih.gov/10378140/ Goossens HA, Nohlmans MK, van den Bogaard AE. Epstein-Barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early Lyme borreliosis. Infection. 1999 May-Jun;27(3):231. doi: 10.1007/BF02561539. PMID: 10378140. Understanding Cross Reactivity For Lyme Disease https://support.everlywell.com/article/362-understanding-cross-reactivity Abbott ARCHITECT Syphilis TP Chemiluminescent Immunoassay Accurately Diagnoses Past or Current Syphilis in Pregnancy https://pubmed.ncbi.nlm.nih.gov/31905408/ Adhikari EH, Frame IJ, Hill E, Fatabhoy R, Strickland AL, Cavuoti D, McIntire DD, Hollaway RM. Abbott ARCHITECT Syphilis TP Chemiluminescent Immunoassay Accurately Diagnoses Past or Current Syphilis in Pregnancy. Am J Perinatol. 2020 Jan;37(1):112-118. doi: 10.1055/s-0039-3400994. Epub 2020 Jan 6. PMID: 31905408. RPR https://www.healthline.com/health/rpr-test#results VDRL https://www.ucsfhealth.org/medical-tests/003515#:~:text=A%20negative%20test%20is%20normal,%2D%20and%20late%2Dstage%20syphilis. Syphilis, The Greatest Imitator Morgellons Discussion • Sep 21 https://anchor.fm/morgellons/episodes/Syphilis--The-Greatest-Immitator-ejvaln Featured Image https://pixabay.com/photos/cat-woman-blue-eyes-portrait-1423844/ Pentagram Clipart Google Search (Creative Commons) https://www.google.com/search?q=pentagram&tbm=isch&tbs=il:cl&rlz=1C1CHBF_enUS798US798&hl=en&sa=X&ved=0CAAQ1vwEahcKEwjYtf3Xg4rsAhUAAAAAHQAAAAAQAg&biw=1903&bih=898#imgrc=hIdWjW9MAPm8vM&imgdii=WgU1cZ3alFRn-M --- Send in a voice message: https://anchor.fm/morgellons/message Support this podcast: https://anchor.fm/morgellons/support

Ref: AADE7TM Self-Care Behaviors. Diabetes Educ. May-Jun 2008;34(3):445-9

Questo mese il dr Fabio Turco ha selezionato questi tre aggiornamenti scientifici: - La scoperta di un modulatore del Sistema Endocannabinoide per la modulazione dell'umore e Il ruolo della PEA e composti simili nel cervello Titolo originale: "Discovery of a NAPE-PLD Inhibitor That Modulates Emotional Behavior in Mice" (Nat Chem Biol. 2020 Jun;16(6):667-675.) - Il caso clinico di 2 pazienti di lombalgia trattati efficacemente con una crema al CBD. Titolo originale: "Cannabidiol (CBD) as a Treatment of Acute and Chronic Back Pain: A Case Series and Literature Review" (J Opioid Manag. May/Jun 2020;16(3):215-218.) - L'utilizzo del terpene-cannabinoide cariofillene per diminuire la dipendenza da nicotina. Titolo originale: "β-Caryophyllene, a Dietary Terpenoid, Inhibits Nicotine Taking and Nicotine Seeking in Rodents" ( Br J Pharmacol. 2020 May;177(9):2058-2072) Musica: Discover, See You @iksonmusic

Dr. Brittney Warren joins the podcast to discuss fellowship matching, step 1 being pass/fail, diversity in orthopedics, and much more. References mentioned in the pod: Do fellowship trained surgeons do better than generalists? APA Virkus, Walter W. MD; Wetzel, Robert J. MD; McKinley, Todd O. MD; Sorkin, Anthony T. MD; Cheesman, Jeffrey S. MD; Hill, Lauren C. BS, CCRC; Kempton, Laurence B. MD Costs and Radiographic Outcomes of Rotational Ankle Fractures Treated by Orthopaedic Surgeons With or Without Trauma Fellowship Training, Journal of the American Academy of Orthopaedic Surgeons: June 15, 2018 - Volume 26 - Issue 12 - p e261-e268 doi: 10.5435/JAAOS-D-16-00687 Link: https://www.ncbi.nlm.nih.gov/pubmed/29787464 Opportunity cost of fellowship Mead, Matthew MD; Atkinson, Theresa PhD; Srivastava, Ajay MD; Walter, Norman MD The Return on Investment of Orthopaedic Fellowship Training, Journal of the American Academy of Orthopaedic Surgeons: October 29, 2019 - Volume Publish Ahead of Print - Issue - doi: 10.5435/JAAOS-D-19-00276 Link: https://www.ncbi.nlm.nih.gov/pubmed/31688369 Evolution of fellowship Harner, Christopher D. MD, FAOA1,a Collaboration Will Create a More Uniform Fellowship Educational Experience: Presidential Address to the AOA, June 28, 2019, The Journal of Bone and Joint Surgery: April 15, 2020 - Volume 102 - Issue 8 - p e34 doi: 10.2106/JBJS.20.00152 Link: https://www.ncbi.nlm.nih.gov/pubmed/?term=32058353 Women in Orthopedic Specialties J Surg Educ. 2020 May - Jun;77(3):564-571. doi: 10.1016/j.jsurg.2019.12.007. Epub 2020 Jan 10. Link: https://www.ncbi.nlm.nih.gov/pubmed/31932218 J Surg Educ. 2020 May - Jun;77(3):491-494. doi: 10.1016/j.jsurg.2019.12.014. Epub 2020 Jan 16. Link: https://www.ncbi.nlm.nih.gov/pubmed/?term=addressing+gender+related+bias+in+surgical+education

Anatomia Radiológica do RetroperitônioREFERÊNCIA BIBLIOGRÁFICAS:1- Scialpi M, Scaglione M, Angelelli G et al. Emergencies in the retroperitoneum: assessment of spread of disease by helical CT. Eur J Radiol 2004; 50(1): 74–832- Mindell HJ, Mastromatteo JF, Dickey KW et al. Anatomic communications between the three retroperitoneal spaces: determination by CT-guided injections of contrast material in cadavers. AJR Am J Roentgenol 1995; 164(5): 1173–1178. 3- Craig WD, Fanburg-Smith JC, Henry LR et al. Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics 2009; 29(1): 261–290.4- Kunin M. Bridging septa of the perinephric space: anatomic, pathologic, and diagnostic considerations. Radiology 1986; 158(2): 361–3655- Molmenti EP, Balfe DM, Kanterman RY et al. Anatomy of the retroperitoneum: observations of the distribution of pathologic fluid collections. Radiology 1996; 200(1): 95–1036- Haddad MC, Hawary MM, Khoury NJ, Abi-Fakher FS et al. Radiology of perinephric fluid collections. Clin Radiol 2002; 57(5): 339–3467- Scali EP, Chandler TM, Heffernan EJ et al. Primary retroperitoneal masses: what is the differential diagnosis? Abdom Imaging 2015; 40(6): 1887–1903. 8- Osman S, Lehnert BE, Elojeimy S et al. A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol 2013; 42(5): 191–2089- Quaia E. Normal Radiological Anatomy of the Retroperitoneum. Medical Radiology, DOI: 10.1007/978-3-540-87597-0_310- Aizenstein RI, Wilbur AC, O'Neil HK. Interfascial and perinephric pathways in the spread of retroperitoneal disease: refined concepts based on CT observations. Am J Roentgenol 1997;168(3):639–64311- Gore RM, Balfe DM, Aizenstein RI et al. The great escape: interfascial decompression planes of the retroperitoneum. Am J Roentgenol 2000; 175(2): 363–37012- Anatomy of the Retroperitoneum. https://doi.org/10.1259/img.12.1.12001013- Coffin A, Boulay-Coletta I, Sebbag-Sfez D, Zins M. Radioanatomy of the retroperitoneal space. Diagn Interv Imaging 2015; 96(2): 171–18614- Ishikawa K, Nakao S, Murakami G et al. Preliminary embryological study of the radiological concept of retroperitoneal interfascial planes: what are the interfascial planes?. Surg Radiol Anat 2014; 36(10): 1079–108715- Lee SL, Ku YM, Rha SE. Comprehensive reviews of the interfascial plane of the retroperitoneum: normal anatomy and pathologic entities. Emerg Radiol 2010; 17(1): 3–1116- Ishikawa K, Nakao S, Nakamuro M, Huang TP et al. The retroperitoneal interfascial planes: current overview and future perspectives. Acute Med Surg 2016; 3(3): 219–22917- Tirkes T, Sandrasegaran K, Patel AA et al. Peritoneal and retroperitoneal anatomy and its relevance for cross-sectional imaging [published correction appears in Radiographics. 2019 May-Jun;39(3):912]. Radiographics 2012; 32(2): 437–451

  Episode 278 is an all inclusive guide to kidney anatomy, health, bloodwork, and MORE for physique and performance based athletes! First I dig into some basics on kidney anatomy and function before moving into some considerations for athletes looking to get bloodwork done to track kidney health, and all before ending with practical application on how to maintain kidney health while pushing for your goals! Also, theres a few references I'll provide below for those looking to take things further!   REFERENCES Adelstein RS, Sellers JR. Effects of calcium on vascular smooth muscle contraction. The American journal of cardiology. Jan 30 1987;59(3):4b-10b.   Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, . . . Nielsen S. Aquaporin water channels--from atomic structure to clinical medicine. The Journal of physiology. Jul 1 2002;542(Pt 1):3-16.   AHA. American Heart Association. Kidney Damage and High Blood Pressure. Available at: http://www.heart.org/HEARTORG/Conditions/HighBloodPressure/WhyBloodPressureMatters/Kidney-Damage-and-High-Blood-Pressure_UCM_301825_Article.jsp. Last updated 9/11/2014a. Accessed 8/10/2014.     Akinwusi PO, Oluyombo R, Ogunro PS, Adeniji AO, Okunola OO, Ayodele OE. Low dose aspirin therapy and renal function in elderly patients. International journal of general medicine. 2013;6:19-24.   Al-Awqati Q, Barasch J, Goldman L (ed.), SchaferAI (ed.). Goldman's Cecil Medicine, Twenty-Fourth Edition. Chapter 117: Structure and Function of the Kidneys; 716-720. Copyright 2012 Saunders, an imprint of Elsevier, Inc. Available at: www.clinicalkey.com Accessed: 6/9/2014.   Alpern RJ, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity. American journal of kidney diseases : the official journal of the National Kidney Foundation. Feb 1997;29(2):291-302.   Amodu A, Abramowitz MK. Dietary acid, age, and serum bicarbonate levels among adults in the United States. Clinical journal of the American Society of Nephrology : CJASN. Dec 2013;8(12):2034-2042.   Anders HJ, Andersen K, Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney international. Jun 2013;83(6):1010-1016.   Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, and Thornalley PJ. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes. 2003;52(8):2110–20   Bae EH, Lee J, Ma SK, et al. alpha-Lipoic acid prevents cisplatin-induced acute kidney injury in rats. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association. 2009;24(9):2692–700   Balakumar P, Bishnoi HK, Mahadevan N. Telmisartan in the management of diabetic nephropathy: a contemporary view. Current diabetes reviews. 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The ongoing opioid epidemic typically refers to adults, but children and adolescents undergoing surgery are at risk of dependence and addiction to opioid medications as well. Dr. Ellen Raney explains how this affects the pediatric population and the devastating statistics surrounding the opioid epidemic. She shares with listeners the many different approaches for pain management that physicians are using when dealing with children in pain. Dr. Raney is a member of the Advocacy Committee of the Pediatric Orthopaedic Society of North America (POSNA) This is her publication, “Raney EM, van Bosse HJP, Shea KG, Abzug JM, Schwend RM.  Current State of the Opioid Epidemic as it Pertains to Pediatric Orthopaedics From the Advocacy Committee of the Pediatric Orthopaedic Society of North America.  J Pediatr Orthop. 2018 May/Jun; 38(5) e238-244”

The following is a short list of salient points related to the podcast and the corresponding source literature. As always, read the source literature and critically appraise it for yourself. Take none of the following as a substitution for local protocol or procedure. 2018 NAEMSP Spinal Immobilization paper https://naemsp.org/resources/position-statements/spinal-immobilization/ Securing a patient to the stretcher mattress significantly reduces lateral motion: Am J Emerg Med. 2016 Apr;34(4):717-21. doi: 10.1016/j.ajem.2015.12.078. Epub 2015 Dec 30. C-Collar limits visible external motion in the intact spine, but not internal motion in the unstable injured spine: Horodyski M, DiPaola CP, Conrad BP, Rechtine GR 2nd. Cervical collars are insufficient for immobilizing an unstable cervical spine injury. J Emerg Med. 2011 Nov;41(5):513-9. doi: 10.1016/j.jemermed.2011.02.001. Epub 2011 Mar 12. PubMed PMID: 21397431. C-Collar increases ICP: Davies G, Deakin C, Wilson A. The effect of a rigid collar on intracranial pressure. Injury. 1996 Nov;27(9):647-9. PubMed PMID: 9039362. C-Collar causes distraction of unstable C-spine: Ben-Galim P, Dreiangel N, Mattox KL, Reitman CA, Kalantar SB, Hipp JA. Extrication collars can result in abnormal separation between vertebrae in the presence of a dissociative injury. J Trauma. 2010 Aug;69(2):447-50. doi:10.1097/TA.0b013e3181be785a. PubMed PMID: 20093981. Lador R, Ben-Galim P, Hipp JA. Motion within the unstable cervical spine during patient maneuvering: the neck pivot-shift phenomenon. J Trauma. 2011 Jan;70(1):247-50; discussion 250-1. doi: 10.1097/TA.0b013e3181fd0ebf. PubMed PMID: 21217496. Spinal immobilization negatively impacts the physical exam: March J et al. Changes In Physical Examination Caused by Use of Spinal Immobilization. Prehosp Emerg Care 2002; 6(4): 421 – 4. PMID: 12385610 Chan D, Goldberg R, Tascone A, Harmon S, Chan L. The effect of spinal immobilization on healthy volunteers. Ann Emerg Med. 1994 Jan;23(1):48-51. PubMed PMID: 8273958. Chan D, Goldberg RM, Mason J, Chan L. Backboard versus mattress splint immobilization: a comparison of symptoms generated. J Emerg Med. 1996 May-Jun;14(3):293-8. PubMed PMID: 8782022. Even Manual In Line Stabilization alone increased difficulty during intubation and increases forces applied to the neck: Thiboutot F, Nicole PC, Trépanier CA, Turgeon AF, Lessard MR. Effect of manual in-line stabilization of the cervical spine in adults on the rate of difficult orotracheal intubation by direct laryngoscopy: a randomized controlled trial. Can J Anaesth. 2009 Jun;56(6):412-8. doi: 10.1007/s12630-009-9089-7. Epub 2009 Apr 24. PubMed PMID: 19396507. Santoni BG, Hindman BJ, Puttlitz CM, Weeks JB, Johnson N, Maktabi MA, Todd MM. Manual in-line stabilization increases pressures applied by the laryngoscope blade during direct laryngoscopy and orotracheal intubation. Anesthesiology. 2009 Jan;110(1):24-31. doi: 10.1097/ALN.0b013e318190b556. PubMed PMID: 19104166. Spinal immobilization makes it harder to breath and decreases forced expiratory volume: “...produce a significantly restrictive effect on pulmonary function in the healthy, nonsmoking man.” Chan, D., Goldberg, R., Tascone, A., Harmon, S., & Chan, L. (1994). The effect of spinal immobilization on healthy volunteers. Annals of Emergency Medicine, 23(1), 48–51. https://doi.org/10.1016/S0196-0644(94)70007-9 Schafermeyer RW, Ribbeck BM, Gaskins J, Thomason S, Harlan M, Attkisson A. Respiratory effects of spinal immobilization in children. Ann Emerg Med. 1991 Sep;20(9):1017-9. PubMed PMID: 1877767. Totten VY, Sugarman DB. Respiratory effects of spinal immobilization. Prehosp Emerg Care. 1999 Oct-Dec;3(4):347-52. PubMed PMID: 10534038. Prehospital providers can effectively apply selective immobilization criteria without causing harm: Domeier, R. M., Frederiksen, S. M., & Welch, K. (2005). Prospective performance assessment of an out-of-hospital protocol for selective spine immobilization using clinical spine clearance criteria. Annals of Emergency Medicine, 46(2), 123–131. https://doi.org/10.1016/j.annemergmed.2005.02.004 Out of 32,000 trauma encounters, a prehospital clearance protocol resulted in ONE patient with an unstable injury that was not immobilized. This patient injured her back one week prior, required fixation, but had no neurological injury: Burton, J.H., Dunn, M.G., Harmon, N.R., Hermanson, T.A., and Bradshaw, J.R. A statewide, prehospital emergency medical service selective patient spine immobilization protocol. J Trauma. 2006; 61: 161–167 Ambulatory patients self extricating with a cervical collar results in less cervical spine motion than with the use of a backboard: Shafer, J. S., & Naunheim, R. S. (2009). Cervical Spine Motion During Extrication: A Pilot Study. Western Journal of Emergency Medicine, 10(2), 74–78. https://doi.org/10.1016/j.jemermed.2012.02.082 Engsberg JR, Standeven JW, Shurtleff TL, Eggars JL, Shafer JS, Naunheim RS. Cervical spine motion during extrication. J Emerg Med. 2013 Jan;44(1):122-7. doi:10.1016/j.jemermed.2012.02.082. Epub 2012 Oct 15. PubMed PMID: 23079144 Lift and slide technique is superior to log roll: Boissy, P., Shrier, I., Brière, S. et al. Effectiveness of cervical spine stabilization techniques. Clin J Sport Med. 2011; 21: 80–88 Despite there not being any randomized control trials evaluating spinal immobilization, patients transferred to hospitals immobilized have more disability than those transported without immobilization: Hauswald, M., Ong, G., Tandberg, D., and Omar, Z. Out-of-hospital spinal immobilization: its effect on neurologic injury. Acad Emerg Med. 1998; 5: 214–219 “Mechanism of injury does not affect the ability of clinical criteria to predict spinal injury” Domeier, R.M., Evans, R.W., Swor, R.A. et al. The reliability of prehospital clinical evaluation for potential spinal injury is not affected by the mechanism of injury.Prehosp Emerg Care. 1999; 3: 332–337 Spinal immobilization in penetrating trauma is associated with an increased risk of death: Vanderlan, W.B., Tew, B.E., and McSwain, N.E. Jr. Increased risk of death with cervical spine immobilisation in penetrating cervical trauma. Injury. 2009; 40: 880–88 Stuke, L.E., Pons, P.T., Guy, J.S., Chapleau, W.P., Butler, F.K., and McSwain, N.E.Prehospital spine immobilization for penetrating trauma-review and recommendations from the Prehospital Trauma Life Support Executive Committee. J Trauma. 2011; 71: 763–769 “The number needed to treat with spine immobilization to potentially benefit one patient was 1,032. The number needed to harm with spine immobilization to potentially contribute to one death was 66.” Haut, E.R., Kalish, B.T., Efron, D.T. et al. Spine immobilization in penetrating trauma: more harm than good?. J Trauma. 2010; 68: 115–121 Vanderlan WB, Tew BE, Seguin CY, Mata MM, Yang JJ, Horst HM, Obeid FN, McSwain NE. Neurologic sequelae of penetrating cervical trauma. Spine (Phila Pa 1976). 2009 Nov 15;34(24):2646-53. doi: 10.1097/BRS.0b013e3181bd9df1. PubMed PMID: 19881402. Velopulos CG, Shihab HM, Lottenberg L, Feinman M, Raja A, Salomone J, Haut ER. Prehospital spine immobilization/spinal motion restriction in penetrating trauma: A practice management guideline from the Eastern Association for the Surgery of Trauma (EAST). J Trauma Acute Care Surg. 2018 May;84(5):736-744. doi:10.1097/TA.0000000000001764. PubMed PMID: 29283970. Use of LSB can cause sufficient pressure to create pressure ulcers in a short period of time: Cordell W:H, Hollingsworth JC, Olinger ML, Stroman SJ, Nelson DR. Pain and tissue-interface pressures during spine-board immobilization. Ann Emerg Med. 1995 Jul;26(1):31-6. PubMed PMID: 7793717. The natural progression of some C-spine injuries is to get worse, sometimes because we force them into immobilization devices, sometimes because of hypotension, vascular injury, or hypoxia, but surprisingly not because of EMS providers… Harrop JS, Sharan AD, Vaccaro AR, Przybylski GJ. The cause of neurologic deterioration after acute cervical spinal cord injury. Spine (Phila Pa 1976). 2001 Feb 15;26(4):340-6. PubMed PMID: 11224879. Reports of asymptomatic but clinically important spine injuries are, at best, dubious: McKee TR, Tinkoff G, Rhodes M. Asymptomatic occult cervical spine fracture: case report and review of the literature. J Trauma. 1990 May;30(5):623-6. Review. PubMed PMID: 2188001. Bresler MJ, Rich GH. Occult cervical spine fracture in an ambulatory patients. Ann Emerg Med. 1982 Aug;11(8):440-2. PubMed PMID: 7103163.

Author: Don Stader, MD Educational Pearls:   Intravenous Tylenol currently is many times more expensive than oral Single ED study comparing the two has methodology flaws and there is a lack of additional evidence to support intravenous over oral formulations solely for pain control Oral Tylenol appears to be at least equally efficacious, though with a slightly slower onset of action   References: Furyk J, Levas D, Close B, Laspina K, Fitzpatrick M, Robinson K, Vangaveti VN, Ray R. Intravenous versus oral paracetamol for acute pain in adults in the emergency department setting: a prospective, double-blind, double-dummy, randomised controlled trial. Emerg Med J. 2018 Mar;35(3):179-184. doi: 10.1136/emermed-2017-206787. Epub 2017 Dec 15. PubMed PMID: 29247042. Jibril F, Sharaby S, Mohamed A, Wilby KJ. Intravenous versus Oral Acetaminophen for Pain: Systematic Review of Current Evidence to Support Clinical Decision-Making. Can J Hosp Pharm. 2015 May-Jun;68(3):238-47. Review. PubMed PMID: 26157186; PubMed Central PMCID: PMC4485512. Summary by Travis Barlock, MS4  | Edited by Erik Verzemnieks, MD

Bacteriophages -- viruses that target and kill bacteria -- were one of the most promising medical treatments of the early 20th century, and were used to treat all sorts of infections, from cholera to staph, and everything in between. But by the 1950s, they had all but died out in the West. This episode tells the story of the humble phage, from its discovery in the waters of the Ganges, love trysts ending in a KGB execution, and to a resurgence of this once forgotten therapy in the 21st century as an answer to antibiotic resistance. Sources:   Abedon ST, Bacteriophage prehistory: Is or is not Hankin, 1896, a phage reference? Bacteriophage. 2011 May-Jun; 1(3): 174–178. Blair JE and Williams REO, “Phage Typing of Staphylococci,” Bull Org mond. Ste, 1961, 24, 771-784. Davis BM and Waldor MK, Filamentous phages linked to virulence of Vibrio cholera, Current Opinion in Microbiology 2003, 6:35-42. d’Herelle F, “Bacteriophage as a treatment in acute medical and surgical infections,” Bull N Y Acad Med. 1931 May; 7(5): 329–348. d'Herelle F.  Sur un microbe invisible antagoniste des baccilles dysenteriques.  CR Acad Sci Paris 1917,163,173-5. Eaton MD, Bayne-Jones S. Bacteriophage Therapy. JAMA 1934; 103:1769-76; 1847-53; 1934-9. Fruciano DE and Bourne S, Phage as an antimicrobial agent: d’Herelle's heretical theories and their role in the decline of phage prophylaxis in the West, Can J Infect Dis Med Microbiol. 2007 Jan; 18(1): 19–26 Hankin EH.  L'action bactericide des eaux de la Jumna at du Gange sur le vibrion du cholere. Ann Int Pasteur (Paris) 1896,10,511-23. Himmelweit F. Combined action of penicillin and bacteriophage on Staphylococci. Lancet. 1945;ii:104. Hicks DJ et al, “Developments in rabies vaccines,” Clin Exp Immunol. 2012 Sep; 169(3): 199–204. Kingwell K, Bacteriophage therapies re-enter clinical trials, Nature, Vol 14, Aug 2015, 515. Jensen MA et al, Modeling the role of bacteriophage in the control of cholera outbreaks, Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12): 4652–4657. Hargreaves KR and Clokie MRJ, Clostridium difficile phages: still difficult? Front Microbiol. 2014 Apr 28;5:184. La Fee S and Buschman H, Novel Phage Therapy Saves Patient with Multidrug-Resistant Bacterial Infection. Retrieved from: https://health.ucsd.edu/news/releases/Pages/2017-04-25-novel-phage-therapy-saves-patient-with-multidrug-resistant-bacterial-infection.aspx Leitner L et al, Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial. BMC Urol. 2017 Sep 26;17(1):90. Pearce J, Louis Pasteur and Rabies: a brief note, Journal of Neurology, Neurosurgery & Psychiatry 2002;73:82. Schooley et al, Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant acinetobacter baumannii infection. Antimicrobial Agent and Chemotherapy, 14 Aug 2017. Strathdee S, How Sewage Saved My Husband's Life from a Superbug, TEDxNashville, retrieved from: https://www.youtube.com/watch?v=AbAZU8FqzX4. Summers WC, Bacteriophage Therapy, Annual Review of Microbiology, Vol. 55:437-451 (Volume publication date October 2001) Summers WC, The strange history of phage therapy. Bacteriophage. 2012 Apr 1; 2(2): 130–133. Taylor M.W. (2014) Introduction: A Short History of Virology. In: Viruses and Man: A History of Interactions. Springer, Cham Thiel, K. (2004). Old dogma, new tricks—21st Century phage therapy. Nature Biotechnology, 22(1), 31–36. Twort FW, An investigation on the nature of Ultra-Microscopic Viruses, The Lancet, Jan 10th, 1914. 101. Wittebole X et al, A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014 Jan 1; 5(1): 226–235. Ujmajuridze et al, Adapted Bacteriophages for Treating Urinary Tract Infections. Front Microbiol. 2018; 9: 1832. Ventola CL, “The Antibiotic Resistance Crisis: Part 1: Causes and Threats,” P T. 2015 Apr; 40(4): 277–283.

Dr. Haines Ely, MD is a board-certified dermatologist, researcher, clinician and Clinical Professor UC Davis University of California Davis School of Medicine, Department of Dermatology. In this remarkable interview, Dr. Ely takes us on a journey that connects dots between nutrition, gastroenterology, microbiology, cardiology, hepatology, immunology and dermatology. His extensive experience and novel discoveries in these diverse fields help us understand what’s causing psoriasis and translate to effective treatments.     Further reading: Ely PH. Is psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggests it is. Clin Dermatol. 2018 May - Jun;36(3):376-389.

Dr. Haines Ely, MD is a board-certified dermatologist, researcher, clinician and Clinical Professor UC Davis University of California Davis School of Medicine, Department of Dermatology. In this remarkable interview, Dr. Ely takes us on a journey that connects dots between nutrition, gastroenterology, microbiology, cardiology, hepatology, immunology and dermatology. His extensive experience and novel discoveries in these diverse fields help us understand what’s causing psoriasis and translate to effective treatments.     Further reading: Ely PH. Is psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggests it is. Clin Dermatol. 2018 May - Jun;36(3):376-389.

Model Railroad Hobbyist magazine - May/June 2010 (Issue 7)

In honor of the Women's March and doomsday (AKA the Inauguration), Jane and Ashley get into cats, pussyhats, and the ACA. Here are this episode's sources, as well as some helpful links: Baun, MM., Bergstrom, N., Langston, NF., Thoma, L. Physiological effect of human/companion animal bonding Nurs Res. 1984 May-Jun;33(3):126-9. Animal companions and one-year survival of patients after discharge from a coronary care unit. Public Health Rep. 1980 Jul-Aug; 95(4): 307–312. Friedmann, E., Katcher, A.H., Lynch, J.J., and Thomas, S.A. Pets and mental health Pet Therapy

How do you approach the child who may be altered?   Altered mental status in children can be subtle.  Look for age-specific behaviors that range from irritability to anger to sleepiness to decreased interaction. In the altered child, anchoring bias is your biggest enemy.  Keep your mind open to the possibilities, and be ready to change it, when new information becomes available. For altered adults, use AEIOU TIPS (Alcohol-Epilepsy-Insulin-Overdose-Uremia-Trauma-Infection-Psychosis-Stroke). Try this for altered children: remember that they need their VITAMINS! V – Vascular (e.g. arteriovenous malformation, systemic vasculitis) I – Infection (e.g. meningoencephalitis, overwhelming alternate source of sepsis) T – Toxins (e.g. environmental, medications, contaminated breast milk) A – Accident/abuse (e.g. non-accidental trauma, sequelae of previous trauma) M – Metabolic (e.g. hypoglycemia, DKA, thyroid disorders) I – Intussusception (e.g. the somnolent variant of intussusception, with lethargy) N – Neoplasm (e.g. sludge phenomenon, secondary sepsis, hypoglycemia from supply-demand mismatch) S – Seizure (e.g. seizure and its variable presentation, especially subclinical status epilepticus)   Case One: Sleepy Toddler 16-month-old who chewed on his grandmother's clonidine patch Clonidine is an alpha-2 agonist with many therapeutic indications including hypertension, alcohol withdrawal, smoking cessation, perimenopausal symptoms.  In children specifically, clonidine is prescribed for attention deficit hyperactivity disorder, spasticity due to cerebral palsy and other neurologic disorders, and Tourette’s syndrome. The classic clonidine toxidrome is altered mental status, miosis, hypotension, bradycardia, and bradypnea.  Clonidine is on the infamous list of “one pill can kill”. Treatment is primarily supportive, with careful serial examinations of the airway, and strict hemodynamic monitoring. Naloxone can partially counteract the endogenous opioids that are released with clonidine's pharmacodynamics. Start with the usual naloxone dose of 0.01 mg/kg, up to the typical adult starting dose is 0.4 mg. In clonidine overdose, however, you may need to increase the naloxone dose (incomplete and variable activity) up to 0.1 mg/kg.  Titrate to hemodynamic stability and spontaneous respirations, not full reversal of all CNS effects.   Case Two: In Bed All Day A 7-year-old with fever, vomiting, body aches, sick contacts.  Altered on exam. Should you get a CT before LP? If you were going to perform CT regardless, then do it. Adult guidelines: age over 60, immunocompromised state, history of central nervous system disease, seizure within one week before presentation, abnormal level of consciousness, an inability to answer two consecutive questions correctly or to follow two consecutive commands, gaze palsy, abnormal visual fields, facial palsy, arm drift, leg drift, and abnormal language. Children: if altered, and your differential diagnosis is broad (especially if you may suspect tumor, bleed, obvious abscess). Influenza is often overlooked as a potential cause of altered mental status.  Many authors report a broad array of neurological manifestations associated with influenza, such as altered mental status, seizures, cranial nerve abnormalities, hallucinations, abnormal behavior, and persistent irritability.  All of this is due to a hypercytokinemic state, not a primary CNS infection.   Case Three: Terrible Teenager 14-year-old brought in for "not listening" and "acting crazy"; non-complaint on medications for systemic lupus erythematosus (SLE). SLE is rare in children under 5. When school-age children present with SLE, they typically have more systemic signs and symptoms.  Teenagers present like adults.  All young people have a larger disease burden with lupus, since they have many more years to develop complications. Lupus cerebritis: high-dose corticosteroids, and possibly IV immunoglobulin.  Many will need therapeutic plasma exchange (TPE), a type of plasmapheresis.   Summary In altered mental status, keep your differential diagnosis open Pursue multiple possibilities until you are able to discard them Be ready to change your mind completely with new information Make sure your altered child gets his VITAMINS (Vascular, Infectious, Toxins, Accident/Abuse, Metabolic, Intussusception, Neoplasm, Stroke)   References Beckman HB, Frankel RM. The effect of physician behavior on the collection of data. Ann Intern Med 1984; 101:692. Fujita K, Nagase H, Nakagawa T et al. Non-convulsive seizures in children with infection-related altered mental status. Pediatrics International. 2015; 57(4):659–664. Gallagher J, Luck RP, Del Vecchio M. Altered mental status – a state of confusion. Paediatr Child Health. 2010 May-Jun; 15(5): 263–265. Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med. 2001; 345(24):1727-33. Oliver WJ, Shope TC, Kuhns LR. Fatal Lumbar Puncture: Fact Versus Fiction—An Approach to a Clinical Dilemma. Pediatrics. 2003; 112(3) Schwartz J et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice—Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Sixth Special Issue. Journal of Clinical Apheresis. 2013; 28:145–284. Zorc JJ. A lethargic infant: Ingestion or deception? Pediatr Ann 2000; 29: 104–107   This post and podcast are dedicated to Teresa Chan, HBSc, BEd, MD, MS, FRCPC for her boundless passion for and support of #FOAMed, for her innovation in education, and for her dedication to making you and me better clinicians and educators.  Thank you, T-Chan. Altered Mental Status Powered by #FOAMed -- Tim Horeczko, MD, MSCR, FACEP, FAAP  

Magazines from May 1981 and a review of Eastern Front (1941) by Chris Crawford, and the triumphant reinstatement of the tech section of the podcast because I've found a manageable topic. Also, info about the Atari Party 2015 which I will attend and give away a Raspberry Pi. Introduction Ringtones and notifications from Atari 8-bit games Thread about building my MAME cabinet Comparing the RPi to the Cray X-MP Raspberry Pi 2 announcement Raspberry Pi 2 specs Atari Party in Davis, CA, May 2, 2015 RetroLink DB9 Joystick to USB cables My original linux driver Improved linux driver Raspberry Pi Model B AtariAge 8-bit High Score Club AtariAge forum thread: 2 worthy video game podcasts S1500's Classic Console Gamernews Tech Section Reverse engineering the classic 1979 game Star Raiders 6502 math operations Simple 8bit division routine Software - Math - Integer Division ANALOG ANALOG #3, May/Jun 1981 ... For 29 more links, see the show notes

Click to Subscribe to All Ben's Fitness & Get A Free Surprise Gift from Ben. Click here for the full written transcript of this podcast episode. Aug 22, 2012 free podcast: What Kind Of Sports Drink or Gel Is Best For Endurance Exercise? Also: upper body strength for swimming, is honey a good energy source, is a "hair analysis" worth while, should you "run through menopause", chlorine sensitivities, dealing with a labrum tear, xenoestrogens and weight changes, cycling and sciatica pain , and ways to deal with metatarsal pain. Have a podcast question for Ben? Click the tab on the right side of the screen, call toll free to 1-877-209-9439, Skype to “pacificfit” or scroll down on this post to access the free “Ask Ben” form. NEW Enhanced Podcast - For those of you with devices that support the M4A file type (Apple, some recent Android, Sonos, Creative Zen, Zune, some Sony, Nintendo DS, Wii, PSP, some Nokia and some Blackberry... and a few more) we have a new "enhanced" version of the podcast... with chapters! Download it here and let us know what you think. If you have trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com. Also, please don't forget to leave the podcast a ranking in iTunes - it only takes a minute of your time and it helps grow our healthy community! ----------------------------------------------------- News Flashes: To get these and other interesting news flashes every week, follow Ben on Twitter and Google+. If your kids are swimming in pools a lot, you need to be giving them antioxidants. Here's why. Simply using an iPad after midnight decreases melatonin production by 23%! Cool way to figure out whether you're a "morning" or an "evening" person. ----------------------------------------------------- Special Announcements: Cooking Class with Ben & Jessa Greenfield: "Make Your Own Probiotics" - Thursday, August 23, 6:30-8pm. Fee: $5 per person – includes recipes and samples. Location: Pilgrim's Health Education Center. Ben is going to be at Ironman Canada - drop him an email or @ him on Twitter if you want to say hi! Need blood testing to find out your health or performance biomarkers? - Ben recommends WellnessFX ----------------------------------------------------- Listener Q&A: As compiled and read by Brock, the Ben Greenfield Fitness Podcast "sidekick". Audio Question from Keith: Wants to know Ben's opinion on Tailwind Endurance Fuel. ~ In my response I mention Osmo Nutrition. Eve asks: I am a typically pear shaped female. I have done strength training diligently for several years, and I have trained for triathlon for almost a year. My upper body strength is really holding me back on the swim. I train swimming 3 times per week. I have worked with swim coaches and have followed numerous strength training protocols with several personal trainers. I bought your book "strength training for triathletes" and followed some of the exercises. I've had improvements in my leg strength, but not in my lats and arms. I eat Paleo with loads of fruit, plenty of protein, litre of milk per day with zero junk and zero gluten. Is there no hope for me? Even my mother can bench more than me :-( ~ In my response to Eve, I mention the SwimSmooth book. Rob asks: I was listening to you and Brock talk about gels and goos today, recommendations for half-marathoning. I started running hardcore last year and I found the half-marathon distance really tough until I started wearing a CamelBak and I was thinking about carrying honey packets with me as a natural source of energy, as opposed to gels and goos. I'm a budget runner as much as possible because I'm a budget sort of wage-earner and I can just grab these honey packets at the local coffeehouse. What do you think about using honey as an energy source during a long-distance run? KaLonny asks: Is there any validity to hair analysis? A local chiropractor offers this test to measure mineral content of your hair and, according to this particular website, "if a particumineral deficiency or toxicity exists in the hair, it usually indicates a mineral deficiency or toxicity within the body. This in turn, provides a great window into the metabolic activity within the body, which allows us to prescribe a unique treatment protocol in order to properly treat your condition. " I am interested for myself, but also for my daughter, who shows characteristics of autism and other behaviour issues. Is it legit or a waste of money? ~ In my response to KaLonny, I recommend these two tests: www.evitalhealth.com/Red_Blood_Cell_Elements.html www.spectracell.com/mnt/#nutrients Hope says: I'm 53 years old and have been going through the side effects of peri-menopause and menopause for many years now. I decided when I was in my later 40's that I would try to "run through menopause". I'm now running about 3 - 4 miles a few times a week and also do different types of cross training. I have completed a 5k and a 10k, but I find that I get too exhausted to put in any real extended mileage. I wanted your input regarding how to deal with the exhaustion, hot flashes and creeping weight gain which has been occurring. I have tried black cohosh and other remedies to no avail. My diet is overall very good - lots of veggies, clean foods, protein and not huge amounts of carbs, except for a treat. My mother had breast cancer twice, so there is no way I'll be touching any hormones. I am trying my best to keep fit and young, but I gotta tell you, it's been tough! ~ In my response to Hope, I recommend listening to my podcast on why women gain weight as they get older and taking a look at the Ben Recommends page. Nadine asks: I am an ex-triathlete who stopped swimming because of a problem with chlorine. Here is what the symptoms are like: after two or three swims in a week, I stop being able to digest fat, get heart palpitations (which I never get otherwise) and generally feel terrible. It took me a long time to figure out what the trigger is until my naturopath did some reflex testing with pool water and figured out that the chlorine in the water goofs up my liver and gall bladder. I stopped swimming in 2005. I do a lot of endurance training but really really want to get back into triathlon. I am going to try a lower chlorine pool in Vancouver but wondered if a) you have encountered this sort of reaction before and b) if you have any ideas about helping out with the chlorine. I have no respiratory symptoms. Shannon asks: I currently have a small tear in my labrum in my left hip. I have an acetabular impingement that seems to be why this has happened. I was a runner and practised a lot of yoga. I have been seeing a yoga therapist and doing physical therapy and my hip has been feeling better. I am not planning on having surgery, because my hip is feeling better. Do you have any suggestions or opinions about workouts? I would love to get back to running, but high impact activities make me nervous. ~ Heal Your Hips book. Sefi asks: Are there any studies that actually look at weight changes in women who avoid xenoestrogens compared to those who don't? ~ Harvey PW, Darbre P. Endocrine disrupters and human health: could oestrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? J Appl Toxicol. 2004 May-Jun;24(3):167-76. ~ Braun JM, Kalkbrenner AE, Impact of early-life bisphenol a exposure on behavior and executive function in children, Pediatrics. 2011 Nov;128(5):873-82. Epub 2011 Oct 24. ~ Roy JR, Chakraborty S, Chakraborty TR. Estrogen-like endocrine disrupting chemicals affecting puberty in humans--a review, Med Sci Monit. 2009 Jun;15(6):RA137-45. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717132/ http://www.epa.gov/ncer/science/endocrine/humanhealth.html http://www.ncbi.nlm.nih.gov/pubmed/17503436 http://www.ncbi.nlm.nih.gov/pubmed/15461258 ~ Jensen TK, et al. Do environmental estrogens contribute to the decline in male reproductive health. Clinical Chemistry December 1995 vol. 41 no. 12 1896-1901.   ~ Ho, S-M, W-Y Tang, J Belmonte de Frausto, and GS Prins. 2006. Developmental Exposure to Estradiol and Bisphenol A Increases Susceptibility to Prostate Carcinogenesis and Epigenetically Regulates Phosphodiesterase Type 4 Variant 4. Cancer Research, Volume 66, Pages 5624-5632. ~ Diamanti-Kandarakis E et al. 2009 Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocrine Reviews 30(4):293-342 ~ Carwile JL, Michels KB, Urinary bisphenol A and obesity: NHANES 2003 – 2006. Environ Res. 2011 Aug;111(6):825-30. Epub 2011 Jun 14. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA. ~ Zsarnovszky A, Le HH, Wang HS, Belcher SM. Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A. Endocrinology. 2005 Dec;146(12):5388-96. Epub 2005 Aug 25. ~ Ayyanan A, Laribi O, et al, ISREC-Swiss Institute for Experimental Cancer Research, National Center of Competence Molecular Oncology, Lausanne, Switzerland. ~ Masuno, H., et al. “Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes.” J lipid Res. 3 (2002): 676-684.   ~ Silver MK, O'Neill MS, Sowers MR, Park SK, PLoS One. 2011;6(10), Urinary Bisphenol A and Type-2 Diabetes in U.S. Adults: Data from NHANES 2003-2008. ~ Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America. ~ Harvey PW, Darbre P. Endocrine disrupters and human health: could estrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? J Appl Toxicol. 2004 May-Jun;24(3):167-76. Andy wrote: I recently "fell" into the sport of road cycling after trying it out last year during a vacation. I have always been active (4th degree Black Belt in Karate) though I now have to work within my sciatica that at times does not allow me to walk without pain. Riding does give me a minor back soreness but it does not hurt me at all! Even though I am now 56 I would like to get into this sport more seriously but with caution. I still have a full time job and yes a growing family thus I have to balance. So, where does one begin to establish a serious, though reasonable overall program that someone like me can use to challenge himself? ~ In my response to Andy, I recommend www.TriathlonDominator.com and www.Tri-Ripped.com Paul asks: I am a 63 yr old 30 + yr. runner. I have flat feet and hammer toes. The last few years I have had nerve pain under second toe on my right foot. I have used a metatarsal pad under toes with relative success. Lately pain hangs on after long runs. I went to a podiatrist and got a cortisone shot for the inflammation and was told I need an orthotic. I've seen insoles with a pad directly behind the ball of the foot designed to take the pressure off the metatarsal bone and would be interested in your view of the best way to approach this problem. ~ In my response to Paul I talk about the How To Run Barefoot post. Prior to asking your question, do a search in upper right hand corner of this website for the keywords associated with your question. Many of the questions we receive have already been answered here at Ben Greenfield Fitness! ====================================== [contact-form-7 id="6222" title="Ask Ben"]======================================

Pedro Serrano Aguilar, Jefe del Servicio de Evaluación y Planificación del Servicio Canario de Salud. “Dentro de las tecnologías sanitarias se incluye absolutamente todo lo que se usa en el sistema sanitario, desde una vacuna a un medicamento, a cualquier equipamiento, independientemente de su complejidad”. Especializado en Medicina Familiar y Comunitaria, el Doctor Serrano también ha recibido formación en Estados Unidos en Investigación en Servicios de Salud y Evaluación de Tecnología Sanitaria. Pedro Serrano participó en el cuarto? programa de ‘Activos en Salud’ a través de una entrevista en la que hablaba de la evaluación en tecnología sanitaria. ------------------------------------------------------------------------------------------- Serrano ha sido jefe de grupo del Área de Investigación en resultados y servicios sanitarios del Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP). Asimismo, ha escrito y colaborado en numerosas publicaciones. Entre las más recientes, se encuentran las siguientes: - Serrano Aguilar, P. et al. Efectividad y seguridad de las alternativas terapéuticas frente a las ataxias degenerativas. Canarias. Consejería de Sanidad y Consumo. - Scientific contributions on Telemedicine: Mahtani Chugani V, Martín Fernández RL, Soto Pedre E, Yanes López V, Serrano Aguilar P. Implementation of telemedicine programs in Spain: experience of the main actors involved in the decision-making process. Gac Sanit. 2009 May-Jun;23(3):223.e223-9. Epub 2009, Feb 27. - Scientific contributions on Evaluative Research Oliva-Moreno J, López-Bastida J, Serrano-Aguilar P, Perestelo-Pérez L. Determinants of health care costs of HIV-positive patients in the Canary Islands, Spain. Eur J Health Econ. 2010 Jan 5. [Epub ahead of print]PMID: 20049503

Guest: Denis Guttridge, PhD, Associate Professor, Molecular Virology, Immunology and Medical Genetics, The Ohio State University Access an abstract of this month’s featured research articles: Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy. J Transl Med. 2011 May 17;9:68. doi: 10.1186/1479-5876-9-68. Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med. 2011 May-Jun;17(5-6):508-15. doi: 10.2119/molmed.2010.00263.

Guest: Denis Guttridge, PhD, Associate Professor, Molecular Virology, Immunology and Medical Genetics, The Ohio State University Access an abstract of this month’s featured research articles: Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy. J Transl Med. 2011 May 17;9:68. doi: 10.1186/1479-5876-9-68. Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med. 2011 May-Jun;17(5-6):508-15. doi: 10.2119/molmed.2010.00263.