Podcasts about WHI

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Best podcasts about WHI

Latest podcast episodes about WHI

The Wonder Women Official
The Menopause BOOM: Science vs Marketing with Dr. Sarah Berg

The Wonder Women Official

Play Episode Listen Later Jun 16, 2026 53:13


What if the menopause industry isn't failing women but instead  it's deliberately targeting them?Michelle MacDonald sits down with scientist, physician, and Selfority founder Dr. Sarah Berg for a conversation that pulls back the curtain on how a $15 trillion industry is built on the gap between what women need and what medicine has historically given them. Together they unpack why midlife women have become the most targeted consumer demographic in wellness, how the "natural" hormone narrative that exploded after the 2002 WHI study opened the door for an entire compounding market, and why so many women are making major health decisions at 3am while sleep deprived and algorithmically cornered. They also dig into the science of the placebo effect including why supplement companies deliberately build their packaging around the same 4 to 8 week window that research shows produces maximum placebo response and what it means to advocate for yourself in a space designed to exploit your vulnerability. This is an episode for every woman who has ever wanted to optimize her health and found herself wondering whether she's being helped or just sold to.Favorite Moments1:35 Why Women Over 50 Are a $15 Trillion Target3:21 The Group Text Is the New MLM7:41 How the 2002 Hormone Scare Built the Compounding Market9:42 Bioidentical Hormones: What the Word Actually Means13:34 The Placebo Study That Should Make You Rethink Every Supplement You've Bought15:27 Why Supplement Packaging Says "Wait 4 to 8 Weeks" and It's Not an Accident17:38 The 2002 Sham Knee Surgery That Proves the Brain Is the Most Powerful Drug We Have24:44 The DUTCH Test: What It Is, What It Can't Do, and Why It Often Leads to a Supplement Stack29:38 Drunk Buying at 3am: Sleep Deprivation, Algorithms, and the Menopause Marketing Machine35:32 Why Your Jeans Stopped Fitting - The Estrogen & Visceral Fat Connection41:36 Skinny Check vs. Frailty Check: The Reframe Women Actually Need46:34 What's Coming: The $24 Billion Menopause Research Bill and Medical School Curriculum Change"They're taking it because they're getting humbled relentlessly by the story that their bodies are broken. And so they're not even looking at the big levers." ~ Dr. Sarah BergGUEST: DR. SARAH BERGFounder, Selfority | Principal Scientist, Unbiased ScienceInstagram: https://www.instagram.com/selfority/Website: https://www.selfority.com/Dr. Sarah Berg is a physician-scientist and fierce advocate for evidence-based communication in women's health. As a Principal Scientist with the Unbiased Science team, she brings clinical expertise and a sharp eye for predatory marketing to one of the most underserved areas in medicine. Through Selfority - a name she built to say "self priority" out loud - she is on a mission to make sure women have the information they actually need to make informed decisions about their health, not just the information someone is trying to sell them.About Michelle:Michelle MacDonald is the creator of the FITNESS MODEL BLUEPRINT™ and host of the Stronger By Design™ podcast. Known globally for her transformation programs, Michelle empowers women to redefine aging through evidence-based strength training, nutrition, and mindset practices. Since 2012, she has coached thousands of women online, leveraging her expertise as a Physique Champion and ISSA Strength and Conditioning Specialist. She co-founded Tulum Strength Club and established The Wonder Women (TWW), inspiring countless transformations including her mother, Joan MacDonald (Train With Joan™). Michelle continues to lead the charge in women's fitness, launching the Stronger by Design™ fitness app in fall 2024.==========================================================If this conversation gave you something to think about, subscribe so you never miss an episode. New conversations drop regularly, all built around the same goal: giving you the tools to take your health and performance seriously, for the long term.==========================================================Stronger by Design Podcast

Baby Or Bust
Ep 174 Menopause Symptoms and Hormone Therapy with the OvaryActive Doctors

Baby Or Bust

Play Episode Listen Later Jun 16, 2026 63:09


Could your sleepless nights, mood swings, joint pain, or "I just don't feel like myself" feelings be connected to perimenopause? Do you really need hormone testing to know what is happening? And is menopause hormone therapy actually as scary as we were once told?  Dr. Rebecca Dunsmoor-Su and Dr. Amy Voedisch, hosts of OvaryActive and co-authors of Estrogen, Interrupted, join Dr. Lora Shahine for this episode of Brave & Curious. Their conversation opens up a thoughtful, funny, and myth-busting conversation about menopause, perimenopause, hormone health, and why women deserve to understand their bodies. They also explain the difference between menopause and perimenopause, why symptoms can start years before periods stop, why hormone labs often do not tell the full story, and how symptoms like hot flashes, night sweats, insomnia, anxiety, vaginal dryness, weight changes, itchy ears (yes, we said "itchy ears"), burning mouth, and joint pain can all fit into the bigger picture. Perimenopause is often a "story-based" diagnosis rather than a single lab result, and treatment options are available. This conversation will walk listeners through all of that and more. Listeners will feel informed, validated, and ready to ask better questions. In this episode you'll hear: [0:24] Meet The Doctors of Ovaryactive Podcast [10:45] Defining menopause and perimenopause [14:55] Common Symptoms (More than Hot Flashes) [18:37] Why labs fall short [23:07] Unusual menopause symptoms [28:05] Diagnosing perimenopause and menopause [32:17] Non-hormonal treatment options [42:18] The WHI study [50:45] Breast cancer risk and Hormone Therapy [59:51] Talking to your doctor   Resources mentioned:  perimenopausedrs.com/ovaryactive Follow the show @OvaryActive Instagram | YouTube  Estrogen, Interrupted by Dr. Rebecca Dunsmoor-Su & Dr. Amy Voedisch   More information about Dr. Rebecca Dunsmoor-Su:  Gennev:  www.gennev.com/clinician/dr-rebecca-dunsmoor-su LinkedIn @rebecca-dunsmoor-su   More information about Dr. Amy Voedisch: Stanford Medical Clinic: stanfordhealthcare.org/doctors/v/amy-voedisch.html   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode!   This episode was produced by Audiotocracy Podcast Production.  

The Reflective Doc Podcast
"It's Your Body." Optimal Health in Perimenopause.

The Reflective Doc Podcast

Play Episode Listen Later Jun 4, 2026 47:05


“Every woman deserves the chance to have a real discussion about hormone therapy — and make whatever decision is right for her. I'm here to give information and answer questions. It's your body.”— Dr. Jacqueline RiedelThe doctor who finally has time for youDr. Jacqueline Riedel, DO spent 15 years in family medicine where she learned this: women's hormonal health in midlife was profoundly under-treated and misunderstood. In a busy hospital-based clinic, she'd start a long-overdue conversation with a patient about perimenopause symptoms… and have to cut it off because the schedule demanded it.So she left. She opened Magnolia Midlife Women's Health, a direct-care practice built on something simple but radical: unhurried, conversational visits where women can actually ask their questions, get real answers, and leave feeling seen.In this conversation, she covers what's really happening hormonally in your 30s, 40s, and 50s and why everything you were told to fear about hormone therapy probably isn't the full story.Perimenopause starts earlier than you thinkDr. Riedel sees women with perimenopause symptoms long before any changes in the menstrual cycle. If you've been dismissed, or told your symptoms are just stress or mom-brain, you're not alone. Symptoms she commonly sees:• New insomnia: can't fall asleep or waking for no apparent reason• Anxiety, often misread as “just life stress”• Persistent, unexplained fatigue• Hot flashes and night sweats• Mood changes including irritability, low mood, brain fog• Cycle irregularities such as heavier periods, irregular timingDr. Riedel's approach: map symptoms to your cycle. When do they happen? Are there patterns? She also rules out other common causes, including thyroid issues and iron deficiency before exploring hormone therapy as an option.MYTH BUSTINGThe fears holding women back from reliefTwo decades after the Women's Health Initiative (WHI) study was misread and sensationalized, fear still dominates the conversation around hormone therapy. Dr. Riedel sets the record straight.Myth 1: Hormone therapy causes breast cancer.Fact: Long-term WHI follow-up showed women in the hormone treatment group had lower rates of breast cancer. Even a first-degree family history is not a contraindication. And if breast cancer does occur in someone using MHT, their risk of dying is actually lower than in those not using it.Myth 2: The doses in MHT are dangerously high.Fact: Menopausal hormone therapy doses are far lower than those in oral contraceptive pills. If you'd prescribe the pill, you can't logically call MHT dangerous.Myth 3: Vaginal estrogen has systemic effects and should be avoided in cancer history.Fact: Topical vaginal estrogen has negligible systemic absorption. It reduces UTIs, yeast infections, urinary frequency, and pelvic floor dysfunction, even in women under active breast cancer treatment, per emerging oncology research. The FDA recently removed the black-box warning.TREATMENT OVERVIEWHow Dr. Riedel approaches careThere's no single protocol. Dr. Riedel listens first, identifying the top two or three symptoms most affecting quality of life, and builds from there.Progesterone for sleep & anxiety• Stimulates GABA production, a calming neurotransmitter• Helps with sleep onset and staying asleep• Reduces the racing mind at 2am• Often the first place she startsEstrogen for vasomotor symptoms• Addresses night sweats, hot flashes, palpitations• Keeps estrogen levels from dropping to “empty”• Preferred as transdermal (patch, gel, spray) to avoid blood clot risk• Added when progesterone alone isn't enoughVaginal estrogen for urogenital health• Reduces painful intercourse and dryness• Decreases UTIs and yeast infections• Supports pelvic floor health long-term• About 50% of women need this even on systemic estrogenNon-hormonal options when hormones aren't right• Newer medications targeting particular neurons in the hypothalamus (hot flash regulation)Things you can do and questions to askDr. Riedel's conversation offers practical starting points for women navigating this transition on their own or with a provider.01. Track your symptoms in relation to your cycleSleep disruption, anxiety, and mood changes that follow a cyclic pattern are often hormonal in origin. Note when in your cycle you feel worst because this information is gold for any provider visit.02. Ask your doctor to rule out thyroid and iron firstFatigue, brain fog, and sleep issues can also come from iron deficiency or thyroid dysfunction. Simple labs can clarify what you're actually dealing with before hormones enter the picture.03. Reconsider what's in your sleep toolkitAlcohol before bed worsens sleep, hot flashes, and anxiety, even though it feels like it helps. Benadryl/ZQuil, Ambien, and benzodiazepines disrupt true sleep architecture. CBT for insomnia has strong evidence and virtually zero side effects. 06. Consider this a second puberty — not a declineMidlife is a genuine developmental threshold. Dr. Riedel and Margaret Mead's concept of “postmenopausal zest” both point in the same direction: this can be a time of clarity, reclaimed energy, and real possibility if you get the support your body actually needs.REFERENCES & RESOURCES[Podcast] Kelly Casperson, MD — You Are Not BrokenUrologist and leading voice in the menopause space. Dr. Riedel's “gateway” into this field. Highly recommended for patients and providers alike.[Course] Rachel Rubin, MD — Physician Webinar SeriesSex medicine specialist and urologist based in Washington, D.C. Physician-only course covering the science of hormones, common fears, and evidence-based prescribing. Her tagline: “What are you afraid of?”[Course] Heather Hirsch, MD — Menopause EducationA well-regarded course for providers wanting to build competence in this space.[Organization] The Menopause Society (formerly NAMS)Membership, certification exam, slide decks, and a comprehensive textbook. menopause.org[Supplement Review] Labdoor.comIndependent third-party testing of supplement brands for purity and label accuracy.FIND DR. RIEDELMagnolia Midlife Women's HealthA direct-care practice built for women who are tired of feeling rushed, dismissed, and underserved. Long visits. Real conversations. Evidence-based care from a physician who actually gets it.Free 15-min consult Not sure if you need this kind of care? Book a quick call to talk through your symptoms and see if Magnolia is the right fit.Website: magnoliamidlife.comInstagram: @magnolia_midlifeUpcoming Event — June 30 Free public lecture at the Haddonfield Public Library: “Is It a Fad?” An evening on perimenopause, evidence, and what women deserve to know. Register through the library website.Thanks for reading A Mind of Her Own! This post is public so feel free to share it.

The Laura Dowling Experience
Dr Caoimhe Hartley | What Menopause Care Should Really Look Like #172

The Laura Dowling Experience

Play Episode Listen Later Jun 4, 2026 57:46


What does proper midlife care actually look like, and who keeps getting left out of it?In this episode, Laura sits down with Dr Caoimhe Hartley - founder of Menopause Health in Dalkey, clinical lead of the Complex Menopause Clinic in the Rotunda, and clinical lead for women's medicine at the new BlackRock Health Women's Health Centre.They talk about the women being told no - those over 60 who feel they have missed the boat on HRT, and those who have come through breast cancer and are still struggling with symptoms. Caoimhe explains where the evidence actually sits on bones, blood vessels and brain, why so much of what gets repeated still comes from the Women's Health Initiative, and how modern HRT differs from the older oral preparations.The conversation moves through midlife weight gain and changing body shape, the rise in adult ADHD diagnoses, and the link between oestrogen and dopamine. They also dig into osteoporosis screening in Ireland, why there is no national DEXA programme, dietary calcium, and the histamine flare some women notice on HRT.Throughout, Caoimhe keeps coming back to the same point - care should be personal, joined up and built around the woman in front of you.

Solving the Puzzle with Dr. Datis Kharrazian
Episode 89: Why Millions of Women Were Failed by the Women's Health Initiative Study

Solving the Puzzle with Dr. Datis Kharrazian

Play Episode Listen Later Jun 2, 2026 18:34


In this episode, we're diving into the complex and often misunderstood topic of menopause and perimenopause. Despite affecting every woman who lives into late life, menopause has long been underfunded, understudied, and minimized both culturally and medically. Today, we'll explore why clinical care for women in the menopause transition has lagged behind, examining the deep historical roots of gender bias in research, the fragmentation of women's healthcare, and the profound impact of the Women's Health Initiative (WHI) study, which triggered decades of fear and misinformation about hormone therapy. Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause00:00 Historical oversight in menopause care06:00 Women's Health Initiative study flaws08:29 Impact of WHI study miscalculation10:28 Misinterpretation of breast cancer risks13:44 Correcting hormone therapy myths17:23 Podcast resources and educational coursesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Solving the Puzzle with Dr. Datis Kharrazian
Episode 88: Hormone Therapy, Breast Cancer, and Menopause

Solving the Puzzle with Dr. Datis Kharrazian

Play Episode Listen Later May 28, 2026 32:27


In today's episode, Dr. Mark Holthouse dives into the fears surrounding breast cancer and hormone replacement therapy, separating myth from evidence with a critical look at the real data. Our expert speaker unpacks the latest clinical trials and position statements, clarifying the nuanced relationship between various hormone therapies and breast cancer risk.We'll explore what the research says about synthetic versus bioidentical hormones, address common patient concerns, and provide actionable insights for risk assessment and individualized care. This episode delivers an integrative approach to hormone therapy and breast cancer, bridging the gap between scientific literature and real-world practice. To enroll in the Sex Steroid Optimization Master Class with Dr. Mark Holthouse, go to https://pages.kharrazianinstitute.com/holthouse-hormoneTo become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 WHI study on hormone therapy04:45 Hormone therapy risks discussion07:58 Discussing natural vs synthetic HRT13:11 Transdermal hormone therapy studies17:55 Rethinking full-fat dairy for women21:11 Time restricted eating for women22:57 Assessing breast cancer risk25:30 Understanding genetic risk factors29:37 Evaluating breast cancer risk factorsSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Speaking of Women's Health
Why estradiol patches are in short supply and what to do

Speaking of Women's Health

Play Episode Listen Later May 27, 2026 43:43 Transcription Available


Send us Fan MailEstradiol patches on backorder, progesterone capsules hard to find, and a lot of anxious scrolling in between. Speaking of Women's Health Podcast host Dr. Holly Thacker recorded this because the hormone therapy supply chain is colliding with a surge in demand, and too many women are getting stuck without a plan. She walks through what's actually driving the patch shortage, how WHI-era fear still shows up in exam rooms, and why “everyone needs a patch” is just as misleading as “no one should take hormones.”If you can't get your usual prescription, you'll hear concrete alternatives: switching patch schedules, considering gels or sprays, using combined estrogen-progestin products, and when nonhormonal therapies for hot flashes and sleep may fit. She ends with a simple preparedness point: don't wait until the last refill day to protect your health. Subscribe, share this with a friend who's struggling to get her meds, and leave a review so more women can find evidence-based menopause care.Support the show

Sky Women
Episode 253: The Hormone Question I Answer Multiple Times a Day: Progesterone vs. Progestins

Sky Women

Play Episode Listen Later May 24, 2026 27:45


Is progesterone the same as a progestin? It sounds like it should be. It is absolutely not. And that distinction matters more than most women — and many providers — realize.This is the conversation Dr. Carolyn Moyers has multiple times a day in clinic — especially with women in perimenopause who are trying to understand their options, figure out why a previous hormone regimen made them feel worse, or advocate for a prescription that actually fits their biology. It is also one of the most consequential mix-ups in all of menopause medicine, and it is long overdue for a dedicated episode.Bioidentical progesterone and synthetic progestins are not interchangeable. They have different molecular structures, different receptor profiles, and meaningfully different effects on your breast tissue, your cardiovascular system, your sleep, and your brain. The WHI study — the one that scared a generation of women off hormone therapy — tested a synthetic progestin, not bioidentical progesterone. And the breast cancer finding it reported was not even statistically significant. That context has been almost entirely missing from the public conversation. Until now.In this episode:• What bioidentical progesterone actually is — and how it differs from synthetic progestins at the molecular level• The WHI study: what it actually tested, and why its results have been misapplied for 20+ years• Breast cancer risk: the ESTHER study and what the evidence actually shows• Cardiovascular differences between progesterone and MPA (Provera)• Why progesterone is a neuroactive steroid — and what that means for your sleep, anxiety, and mood• Uterine protection: what it is, why it matters, and whether bioidentical progesterone is sufficient• What to do if you don't have a uterus — and whether you still need progesterone• Perimenopause: why the progestogen conversation is completely different when you still have cycles, variable ovarian function, and potentially need contraception• The levonorgestrel IUD, norethindrone acetate 5mg vs. the minipill, and Slynd (drospirenone 4mg) — what each one does and who it's for• Exactly how to advocate for yourself at your next appointmentResources mentioned:• ESTHER Study (Fournier et al.) — progesterone vs. MPA and breast cancer risk• Women's Health Initiative (2002)• Prometrium prescribing information• Labia Logic (@labialogic) — vulvovaginal specialists | Memorial Day vulvar health post: instagram.com/p/DYqK9uvj2M8• Sky Women's Health Podcast — Episode 158: Progesterone Intolerance | podcasts.apple.com/gb/podcast/episode-158-progesterone-intolerance/id1541657642?i=1000640152675Work with Dr. Moyers: skywomenshealth.com | In-person: Fort Worth, TX | Virtual: Texas & West Virginia

Everyday Wellness
Ep. 597 “Estrogen Is Protective”– Dismantling 25 Years of Hormone Fear and Cancer Misinformation with Dr. Jordan Emont | Menopause, Perimenopause, Estrogen

Everyday Wellness

Play Episode Listen Later May 23, 2026 59:41


Today, I'm thrilled to connect with Dr. Jordan Emont. He is a board-certified OB-GYN with specialty training in menopause medicine, integrative hormonal care, and sexual health, and is one of fewer than 5,000 physicians worldwide who hold the Menopause Society-certified practitioner designation. In this conversation, we unpack the fear narrative surrounding HRT and clarify the distinctions between estrogen, progesterone, and cancer risk. We explore the impact of the Women's Health Initiative and discuss why rigid dogmatism has no place in women's health, the risks associated with early menopause and premature ovarian insufficiency, individual risk stratification, and contraindications to HRT. We also examine the connection between gut health and colorectal cancer, metabolic health as a modifiable cancer risk, and the emotional side of middle age and hormone replacement therapy. Stay tuned for one of the most important and thought-provoking conversations we've ever had on the podcast. IN THIS EPISODE, YOU WILL LEARN: How fears about hormone therapy are often based on outdated or misinterpreted data The difference between physiologic hormones and synthetic hormone formulations How the Women's Health Initiative's messaging that HRT causes breast cancer comes from an oversimplification of data How the fear-driven WHI headlines continue to impact women's and clinicians' thoughts about hormone replacement therapy  How women's concerns about menopause, sexual health, and menstrual symptoms are often dismissed The health risks associated with early menopause and premature ovarian insufficiency How declining estrogen levels affect multiple body systems, including gut-related and immune-related pathways Why is insulin resistance a major concern?  True contraindications for avoiding HRT Bio: Dr. Jordan Emont Dr. Jordan Emont is a board-certified OB/GYN and Menopause Certified Practitioner who specializes in menopause care for women who've been dismissed, undertreated, or told their symptoms are just part of aging. He's here to change that conversation. He trained at Yale, Brown, and Columbia, and is now an adjunct clinical faculty member at Stanford. He works at a community health center in the Bay Area, providing care to underserved populations, and runs his own private telehealth practice focused on complex menopause care. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Jordan Emont On his website Instagram and Substack

Strong + Unfiltered
EP 251: The Truth About HRT: Blood Clots, Cancer Risk, Pellets + Perimenopause Symptoms

Strong + Unfiltered

Play Episode Listen Later May 18, 2026 49:05


Welcome back to Strong + Unfiltered. Today's episode is a solo Q&A all about hormone replacement therapy, perimenopause, progesterone, estrogen, blood clot myths, and the massive amount of misinformation women are still being fed about hormones. We're diving into the REAL differences between birth control and bioidentical HRT, what the WHI study actually did (and didn't) show, why some women are safer ON estrogen than off of it, and why "just wait until menopause" is outdated advice that's keeping women suffering unnecessarily. I also break down pellets, PCOS and HRT, cyclic estrogen dosing, how I monitor hormones in practice, and why symptoms like anxiety, rage, fatigue, sleep issues, brain fog, joint pain, and "not feeling like yourself" may absolutely be connected to perimenopause long before your periods disappear. If you've ever been told your labs are "normal" while you feel exhausted, anxious, inflamed, ragey, wide awake at 2am, or completely unlike yourself… this episode is for you. Get your  FREE 9 HRT Myths Debunked ebook here Book an Empowered Medicine consult call here  Book a Hormone Strategy Session here  Enter the GIVEAWAY to win a FREE brick here  

Real Health and Weight Loss Podcast
308 Can HRT Prevent Dementia?

Real Health and Weight Loss Podcast

Play Episode Listen Later May 18, 2026 28:22


Did you know women are twice as likely to develop Alzheimer's disease as men, and oestrogen may be a key reason why? In this episode, Dr Lucy Burns and Dr Mary Barson break down the real science behind oestrogen's role in brain health and dementia prevention, why the infamous 2003 WHI study sent doctors running scared for decades, and what the latest evidence actually means for women in midlife. If MHT is not right for you, don't worry, protecting your brain is never a one-trick pony. This is the episode every woman in midlife needs to hear. Research mentioned in this episode: Paganini-Hill A, Henderson VW. Archives of Internal Medicine. 1996 Kim YJ et al. Alzheimer's & Dementia. 2021 Nerattini M et al. Frontiers in Aging Neuroscience. 2023 Cipriano GL et al. International Journal of Molecular Sciences. 2024 Melville NA et al. The Lancet Healthy Longevity. 2025 For more information about Real Life Medicine and our programs and special offers: https://www.rlmedicine.com/ Episode, show notes & transcript https://www.rlmedicine.com/can-hrt-prevent-dementia See omnystudio.com/listener for privacy information.

Better with Dr. Stephanie
Your Gynecologist Can't Fix This: The Cardiometabolic Side of Menopause with Dr. Heather Hirsch

Better with Dr. Stephanie

Play Episode Listen Later May 11, 2026 69:15


The single biggest lie women have been told about perimenopause? That it's a gynecological problem. Dr. Heather Hirsch — board-certified internist, Harvard faculty, and founder of one of the first hospital-based menopause clinics in the US — is done with that framing. In this episode, Dr. Hirsch joins Stephanie to dismantle the assumption that perimenopause begins and ends with a reproductive doctor. This is a cardiometabolic transition. Full stop. Estrogen isn't just a period hormone — it's a vasodilator, a bone protector, an insulin sensitizer, and a vessel guardian for your brain and heart. When it starts to shift, so does everything else. This conversation goes deep on what's actually happening in your body during perimenopause — and what to do about it before the downstream consequences become irreversible. Episode Overview: (0:00) Intro/Teaser (1:13) Full intro + guest bio (4:19) The biggest lie about perimenopause (5:30) Early signs to watch for (7:39) Brain fog vs. hot flashes (10:26) HRT as a diagnostic tool (16:16) The cardiometabolic case (22:39) What the WHI actually shows (30:47) Why doctors resist HRT (38:13) HRT at 60, 70+ (40:36) Bone health and the DEXA gap (50:54) Weight gain is hormonal (56:38) Dr. Hirsch's personal inventory (1:03:43) The menopause types framework (1:09:51) Why postmenopause can be the best chapter (1:12:55) After Party: Dr. Stephanie's takeaways Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep468 We are grateful to our sponsors: KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off your purchase. QUALIA CREATINE+ - If you want to feel stronger, sharper, and more resilient, Qualia's Creatine+ is my recommendation.Go to https://qualialife.com/better  and use code BETTER to save up to 50%, plus an additional 15% off.  OXFORD HEALTHSPAN PRIMEADINE - Support memory, hormones, and hair growth. Save 15% at https://OxfordHealthspan.com/DrStephanie with code DrStephanie15. LMNT  - Stay hydrated without the sugar, food dye, and other dodgy ingredients found in popular electrolyte and sports drinks. Receive a free LMNT Sample Pack with any order when you make a purchase at https://DrinkLMNT.com/Better INCREDIWEAR - Whether you're an athlete, dealing with chronic joint pain, or just someone who wants to feel better in your body — this is worth trying. Head to https://drstephanieestima.com/incrediwear and use code DRSTEPH20 for 20% off your order. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Women Making Moves
HRT's...Where Are We? w/ Elizabeth Kelly

Women Making Moves

Play Episode Listen Later May 7, 2026 45:43


Menopause Care, Misinformation, and Advocacy: Nurse Betsy ReturnsAmy Pons welcomes back repeat guest Elizabeth “Nurse Betsy” Kelly, a board-certified adult geriatric primary care nurse practitioner with extensive ICU/ER experience, work with Doctors Without Borders in Ethiopia and Malawi, and 13 years serving nursing home patients at Sinai Chicago. They discuss rapid changes in midlife women's health education and access to menopausal hormone treatment, emphasizing that the 2002 WHI study was widely miscommunicated, fueling fear of breast cancer and leaving many boomer women without treatment. Betsy explains that starting menopausal hormone treatment within 10 years of the last period can be protective, that transdermal estrogen reduces clot risks compared with oral forms, and that care is individualized; she notes FDA-approved indications and the lack of coverage and research for testosterone in women. They also address misinformation, holistic approaches alongside Western medicine, key supplements (magnesium, vitamin D, omega-3, L-methylfolate), and close with advocacy concerns about a 2026 federal student loan rule deeming nursing not a professional degree, restricting access to graduate programs.00:00 Welcome and Guest Intro01:23 Why Womens Health Matters Now02:35 Why Betsy Is Back04:28 WHI Study and Lost Generation07:34 Modern MHT Benefits17:30 MHT vs HRT Explained22:18 Testosterone and Insurance26:42 Healthy Masculinity and Energy33:12 Holistic Care Meets Medicine36:12 Supplements That Help41:52 Avoiding Wellness Snake Oil43:07 Where to Find Betsy44:18 Final Advocacy CallFind Nurse Betsy on Instagram and Facebook @Stay In Your Cortex, and at https://stayinyourcortex.comThank you for tuning in to Women Making Moves, be sure to rate and subscribe to the show on your favorite podcast platform and follow along on Instagram and Bluesky. Visit Amy at Unlock the Magic, and follow on Instagram and LinkedIn.Women Making Moves is for personal use only and general information purposes, the show host cannot guarantee the accuracy of any statements from guests or the sufficiency of the information. This show and host is not liable for any personal actions taken.

The Humble Skeptic
The Cambridge Declaration

The Humble Skeptic

Play Episode Listen Later Apr 21, 2026 78:51


In an attempt to make churches more attractive and relevant, over the decades, many pastors effectively stopped preaching and teaching the contents of the Bible, and this has resulted in a significant decrease in basic Bible literacy among Christians across all denominations. Thirty years ago today, a diverse group of leaders and theologians met in Cambridge, Massachusetts, to address this and other challenges, and they produced an important document called The Cambridge Declaration. This program features audio from the 1996 meeting featuring R.C. Sproul, James M. Boice, David Wells, Michael Horton, Gene Veith, W. Robert Godfrey, and others.SHOW NOTESBooksHere We Stand, 2026 edition, Jim Boice & Ben Sasse (editors)No Place for Truth, David WellsGod in the Wasteland, David WellsReaching Out Without Dumbing Down, Marva DawnPeculiar Speech, Peculiar Speech, William WillimonChristless Christianity, Michael HortonThe Christian Mind, Harry BlamiresChristianity & Liberalism, J. Gresham MachenCreed or Chaos? by Dorothy Sayers — FREEArticlesThe Cambridge Declaration (also via PDF download here)Background to The Cambridge Declaration, WikipediaThe Story of Us, Shane RosenthalThe Megachurch Century, Shane RosenthalThe Tower of Babel, Shane RosenthalThe Mormonization of American Christianity, Shane RosenthalFinding Christ in All of Scripture (PDF), Shane RosenthalLiberalism or Christianity?, J. Gresham MachenThe Importance of Christian Scholarship, by J. Gresham MachenTheologically, This Country is in a State of Utter Chaos, Dorothy SayersWhy Johnny Can't Preach, T. David GordonAudioThe Living Church, WHI #317 with Ervin DugganDoctrine, Worship & Life, WHI #323 with Jim BoiceCatechesis, Preaching & Vocation, WHI #317 with Gene VeithThe Courage to Be Protestant, WHI #913 with David WellsGrounded in the Gospel, WHI #986 with J.I. PackerYouth Ministry in Crisis, WHI 1204 with Christian Smith & othersA Debate with Robert Schuller, WHI # 103You Foolish Galatians! WHI #140 includes Shane's street interviewsAn Interview with R.C. Sproul, WHI #909The Preached Word, WHI 972 with William WillimonJacob's Ladder, Humble Skeptic #63Christian Narcissism, Humble Skeptic #67 with J.I. Packer & othersThe Effect of Media & Technology, Humble Skeptic #30VideoBen Sasse on Uncommon Knowledge with Peter RobinsonBen Sasse on Interesting Times with Ross DouthatBen Sasse on Life Cancer & The Gospel, with Mike HortonWe Need Your Help!Consider supporting The Humble Skeptic podcast by making a one-time gift or upgrading to a paid subscription via Substack ($5.95 per month, $59 per year). Use the button below for more information about giving options. Get full access to The Humble Skeptic at www.humbleskeptic.com/subscribe

Fertility in Focus Podcast
The Benefits of HRT & Testosterone for Women Undergoing Fertility Treatment with Dr. Kevin Jovanovic, MD, OB/GYN

Fertility in Focus Podcast

Play Episode Listen Later Apr 1, 2026 39:31


In this enlightening episode of Fertility in Focus, Dr. Christina Burns sits down with Dr. Kevin Jovanovic, MD, a leading expert in reproductive medicine and hormone optimization. Dr. Jovanovic shares his expertise on the intersection of fertility, hormones, and overall reproductive health, offering practical insights into improving egg quality, addressing hormonal imbalances, and supporting long-term reproductive wellness. This episode is perfect for anyone seeking to understand the science behind fertility and innovative strategies to enhance reproductive outcomes. In This Episode, You'll Learn:The role of testosterone in reproductive health  Potential uses in fertility treatment The role of testosterone in overall hormonal health and well-being  How HRT got a bad reputation Cosmetic gynecology options for women How low-level hCG may improve IVF outcomes The benefits of peptidesTimestamps:[00:01] Introduction to the podcast and today's topic [02:10] Meet Dr. Kevin Jovanovic and his background in OB-GYN and innovation [05:30] The history of hormone therapy and the impact of the 2002 WHI study [09:45] What are bioidentical hormones and how do they work? [14:20] Testosterone in women: Myths, benefits, and fertility impact [20:10] Signs of hormonal imbalance and testosterone deficiency [27:30] Birth control and its effects on fertility markers like AMH [35:00] Hormone therapy and its potential to improve ovarian function [42:15] Male fertility: Testosterone therapy and sperm production [48:30] Peptides explained: Benefits, uses, and safety considerations [55:40] Weight loss, metabolism, and fertility optimization strategies [01:05:10] Vaginal rejuvenation and integrative women's health treatments [01:12:00] Final thoughts and where to find Dr. Jovanovic Connect with Dr. Kevin Jovanovic: Website: Dr.Jovanovic.com Location:  935 Fifth Avenue, East 74th Street, Upper East Side, Manhattan, New York, NY  Phone: (212) 249-6709About Dr. Christina Burns:Dr. Christina Burns is the founder and Doctor of Chinese Medicine at the Naturna Institute. Committed, compassionate, and highly skilled in multiple disciplines, Dr. Burns has been in practice since 2004. She empowers both women and men to achieve their optimal life and health goals through natural medicine practices, integrative nutrition, lifestyle management, and personalized mind-body programs. Dr. Burns holds advanced certifications in acupuncture, herbs, nutrition, life coaching, and yoga therapy. She is also the best-selling author of "The Ultimate Fertility Guidebook."Connect with Dr. Christina Burns:Website: https://www.christinaburns.com/Instagram: https://www.instagram.com/drchristinaburns/Order the Ultimate Fertility Guidebook: https://a.co/d/hq0nFOoJoin the Eating for Optimal Fertility Course: https://naturna.mn.co/Order Junk Juice: https://junkjuicemagic.com/Follow along with the Naturna Institute:Book an Appointment: https://naturna.janeapp.com/#/listInstagram: https://www.instagram.com/naturna_life/

The Ultimate Human with Gary Brecka
253. Dr. Jessica Shepherd: On Menopause, HRT, and Longevity Tips for Women

The Ultimate Human with Gary Brecka

Play Episode Listen Later Mar 17, 2026 81:51


Most women spend years dismissing their own symptoms: brain fog, frozen shoulder, mood crashes, vanishing libido, never realizing these aren't signs of aging, they're signals of a hormonal shift that begins nearly a decade before menopause hits. Today, I'm with board-certified OB-GYN and menopause expert Dr. Jessica Shepherd to dismantle the myths that have kept millions of women unnecessarily suffering, including the misrepresented WHI study that put hormone therapy off the table for a generation. CLICK HERE TO BECOME GARYS VIP!: ⁠https://bit.ly/4ai0Xwg⁠ Listen to “The Hers Podcast” on all your favorite platforms! YouTube: ⁠https://bit.ly/4shfwbQ⁠  Apple Podcasts: ⁠https://bit.ly/4doq3x2⁠  Get Dr. Jessica Shepherd's book, “Generation M: Living Well in Perimenopause and Menopause” here: ⁠https://bit.ly/3NGDjmn⁠  Connect with Dr. Jessica Shepherd Website: ⁠https://bit.ly/3Pf6ZHG⁠  YouTube: ⁠https://bit.ly/47La74k⁠  Instagram: ⁠https://bit.ly/3NG17Xu⁠  TikTok: ⁠https://bit.ly/416VYLb⁠  Facebook: ⁠https://bit.ly/4ryjyeE⁠  X.com: ⁠https://bit.ly/4192QaQ⁠  LinkedIn: ⁠https://bit.ly/3Nhrm6x⁠  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: ⁠http://bit.ly/4kek1ij⁠ AION: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4h6KHAD⁠ AIRES: "ULTIMATE20 " FOR 20% OFF: ⁠https://bit.ly/4a3Duze⁠ BAJA GOLD: "ULTIMATE10" FOR 10% OFF: ⁠https://bit.ly/3WSBqUa⁠ BODYHEALTH: “ULTIMATE20” FOR 20% OFF: ⁠http://bit.ly/4e5IjsV⁠ CARAWAY: “ULTIMATE” FOR 10% OFF: ⁠https://bit.ly/3Q1VmkC⁠ COLD LIFE: THE ULTIMATE HUMAN PLUNGE: ⁠https://bit.ly/4eULUKp⁠ GENETIC METHYLATION TEST (UK ONLY): ⁠https://bit.ly/48QJJrk⁠ GENETIC TEST (USA ONLY): ⁠⁠https://bit.ly/3Yg1Uk9⁠ GOPUFF: GET YOUR FAVORITE SNACK!: ⁠https://bit.ly/4obIFDC⁠ H2TABS: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4hMNdgg⁠ HEALF: 10% OFF YOUR ORDER: ⁠https://bit.ly/41HJg6S⁠ PEPTUAL: “TUH10” FOR 10% OFF: ⁠https://bit.ly/4mKxgcn⁠ RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: ⁠https://bit.ly/44fFza0⁠ SNOOZE: LET'S GET TO SLEEP!: ⁠https://bit.ly/4pt1T6V⁠ WHOOP: JOIN & GET 1 FREE MONTH!: ⁠https://bit.ly/3VQ0nzW⁠ Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠ X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 Intro of Show 04:20 Dr. Jessica Shepherd's Background 08:03 Perimenopause: Earlier Than You Think 11:35 Early Signs of Menopause 15:24 Dutch Test and Hormone Replacement Therapy 24:06 Ideal Timeframe for Hormone Therapy 26:33 The Invisible Hormone Disruptors 27:23 The Caregiver Syndrome 28:35 Why Autoimmune Disease Targets Women 30:40 What Does a Healthy Immune System Look Like? 34:38 Blood Sugar Monitoring: HbA1c and CGM 41:50 How to Strengthen Women's Immune System 47:42 Black Maternal Mortality and Systemic Health Gaps 57:23 Dr. Shepherd's Message to the Administration 58:43 Role of AI in Healthcare 1:01:40 Generation M: The Book Every Woman Needs 1:03:39 Weight Training as a Longevity Non-Negotiable 1:06:10 Dr. Shepherd's Morning Routine 1:08:13 Creatine for Muscle and Brain Health 1:12:28 Real-World Recovery: Movement, Nutrition, and Supplements 1:17:14 Connect with Dr. Shepherd 1:21:01 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Learn more about your ad choices. Visit megaphone.fm/adchoices

Sisters-in-Service
The Apology Tour with Dr. LaKeischa McMillan - Removal of the Black Box Warning on Hormone Replacement Therapy

Sisters-in-Service

Play Episode Listen Later Mar 17, 2026 38:19


For decades, women were told to fear hormone therapy. Much of that fear stemmed from the highly publicized Women's Health Initiative Study (WHI), a study that dramatically changed the conversation around menopause and hormone therapy in the early 2000s. Headlines spread quickly. Hormones became the villain. And millions of women were left confused, unsupported, and often suffering through symptoms without answers. But today, the conversation is changing. In this episode, we sit down with Dr. LaKeischa - creator of The Apology Tour, to unpack what really happened after the WHI study, why fear took over the narrative, and why the recent **U.S. Food and Drug Administration decision to remove the black box warning from certain estrogen products is such a major moment for women's health. This conversation is about more than hormones. It's about correcting misinformation, empowering women with facts, and rewriting the story of **menopause and **perimenopause for the next generation. If you've ever wondered whether the information women received about hormones was incomplete—or simply wrong—this episode will open your eyes. info@drlakeischamd.com

This Functional Life
Is It Too Late to Start Hormone Replacement Therapy?

This Functional Life

Play Episode Listen Later Mar 4, 2026 50:56


Menopause Mastery Show | Starting HRT After 65: Is It Too Late? Transdermal Estrogen and Bone, Sleep & Dementia Risk   Welcome to Menopause Mastery! In this episode, Dr. Betty Murray examines whether starting menopausal hormone therapy after age 65 is always unsafe, arguing that blanket "no" answers stem from an evidence vacuum and fear following the 2002 Women's Health Initiative (WHI), which used oral conjugated equine estrogen and synthetic progestins.    Dr. Murray contrasts oral therapy's first-pass liver metabolism and clotting risk with transdermal bioidentical estradiol, which has observational and retrospective data (including a large Medicare analysis) associated with no increased DVT, stroke, or heart attack risk. She highlights evidence for fracture reduction and maintained vertebral bone density with long-term therapy, discusses sleep benefits (a modifiable dementia risk factor), notes limited cognitive trials in older starters, and emphasizes individualized risk assessment (cardiovascular screening, genetics like APOE4) and monitoring; she also recommends vaginal estrogen to reduce UTIs and urosepsis risk.    This episode is for women who feel they may have missed their window on starting HRT, and why it may not be too late. In fact, women of all ages will benefit from this information, so don't forget to share it with someone you know!    00:00 HRT After 65 02:36 The Evidence Vacuum 04:55 Myth of the Window 06:27 WHI vs Modern Estrogen 08:36 Transdermal Safety Data 10:08 Why Observational Counts 14:51 Risk Math in Your 70s 19:32 Bone Density Benefits 23:08 Sleep and ApoE4 24:30 APOE4 Risk Basics 25:07 Sleep as Brain Protection 25:55 Transdermal Estrogen for Sleep 27:12 Insomnia Raises Dementia Risk 28:22 Personalizing HRT for Sleep 30:03 Cardiovascular Risks and Screening 34:56 Evidence Gaps and WHI Context 38:38 APOE4 Sleep and Estradiol Link 40:09 Decision Framework Over 65 43:08 Monitoring and Follow Up 45:47 Alternatives and Tradeoffs 48:16 Vaginal Estrogen and Wrap Up   Connect with Dr. Betty Murray:  Betty Murray Website: https://www.bettymurray.com/ Instagram: https://www.instagram.com/drbettymurray/   Like, comment, and subscribe on YouTube:  @drbettymurray     Links:  The Fierce Female Method for Longevity (Dr. Betty's book): https://fierce.hormoneshelp.com/  Menrva Telemedicine: https://gethormonesnow.com/  FREE Hormone Quiz: https://bit.ly/3wNJOec  Living Well Dallas: https://www.livingwelldallas.com/  Hormone Reset: https://hormonereset.net/   More from the Podcast:  Subscribe to #MenopauseMastery → https://www.youtube.com/channel/UCwONPdSvb2-YYY74VhD-XBw  Apple Podcasts → https://podcasts.apple.com/us/podcast/menopause-mastery/id1607369247  Spotify → https://open.spotify.com/show/0tNsjm32CZNXSgSFEwS3uH   Thank you for listening to Menopause Mastery. Empowering your health journey, one episode at a time.  

Dr. Brendan McCarthy
The Progesterone Promise: Why Context Matters More Than the Hype

Dr. Brendan McCarthy

Play Episode Listen Later Feb 18, 2026 27:54


In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women's health: progesterone. Progesterone is not “good” or “bad.” It's contextual. In today's world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like “progesterone fixes anxiety” or “progesterone causes breast cancer.” The truth? It depends on your body, your stress levels, your liver health, your inflammation, your delivery method, and whether you're using bioidentical progesterone or synthetic progestins.   Citations: 1. Oral Progesterone → First-Pass Metabolism & Allopregnanolone Claim: Oral micronized progesterone undergoes significant hepatic first-pass metabolism, increasing neuroactive metabolites (especially allopregnanolone), which positively modulate GABA-A receptors and produce sedative/anxiolytic effects. Core Evidence: Simon et al., 1993; de Lignières et al., 1995; Freeman et al., 1990 — Oral progesterone produces measurable neuroactive metabolites. Paul & Purdy, 1992; Rupprecht et al., 2001 — Allopregnanolone enhances GABA-A receptor activity. Supports: Sedation variability by route • Neurosteroid generation • GABA-A modulation 2. Sulfation vs 5α-Reduction → Opposing Neurologic Effects Claim: Progesterone metabolites can produce calming (5α-reduced) or excitatory (sulfated) neurologic effects depending on enzyme routing. Core Evidence: Majewska et al., 1990 — Pregnenolone sulfate negatively modulates GABA-A. Wu et al., 1991 — Sulfated neurosteroids enhance NMDA signaling. Schumacher et al., 2007; Reddy, 2010 — Pathway reviews of sulfation vs 5α-reduction. Supports: Reverse responding hypothesis • Divergent neurologic experiences • Enzyme-dependent effects 3. Stress & Enzyme Modulation Claim: Chronic stress alters HPA axis tone and hepatic enzyme expression, influencing steroid metabolism balance. Core Evidence: McEwen, 1998 — Allostatic load model. Charmandari et al., 2005 — Cortisol's systemic regulatory effects. Zanger & Schwab, 2013; Gibson & Skett, 2001 — Stress alters cytochrome P450 expression. Supports: Stress-biased metabolism • Context-dependent hormone response 4. Breast Tissue Signaling & Context Claim: Progesterone influences mammary differentiation and interacts with estrogen signaling in context-dependent ways. Core Evidence: Brisken & O'Malley, 2010 — Progesterone receptor biology in breast tissue. Beleut et al., 2010 — RANKL mediates progesterone-driven proliferation. Hofseth et al., 1999 — PR-ER signaling interaction. Stanczyk & Bhavnani, 2014 — Natural vs synthetic differences in breast effects. Supports: Lobuloalveolar differentiation • RANKL pathway • Context-dependent proliferation 5. Synthetic Progestins vs Bioidentical Progesterone Claim: Synthetic progestins differ structurally and bind off-target receptors, producing distinct tissue effects. Core Evidence: Stanczyk et al., 2013 — Receptor binding differences. Sitruk-Ware, 2004 — Biologic comparisons. Chlebowski et al., 2003 (WHI) — Breast cancer signal with CEE + MPA. Supports: Structural divergence • Receptor-level differences • WHI clarification 6. Route of Delivery Differences Claim: Oral, vaginal, transdermal, and sublingual progesterone produce distinct pharmacokinetic profiles and tissue targeting. Core Evidence: Simon, 1995 — Oral vs vaginal PK comparison. Cicinelli et al., 2000 — “First uterine pass effect.” Wren et al., 2003 — Route-dependent systemic levels. Supports: Uterine targeting • Neurosteroid variability • Sedation differences 7. Progesterone, PMS & Migraine Claim: Neurosteroid fluctuations influence GABAergic tone and may contribute to PMS and migraine susceptibility. Core Evidence: Backstrom et al., 2011 — Allopregnanolone fluctuations in PMS. Reddy & Rogawski, 2002 — Neurosteroids and seizure threshold. Martin & Behbehani, 2001 — Hormonal fluctuations and migraine. Supports: Luteal neurosteroid shifts • GABA instability • Migraine association   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Parenting and Personalities
It's Not You. It's Your Hormones…And Menopause Is Why.

Parenting and Personalities

Play Episode Listen Later Feb 17, 2026 34:24 Transcription Available


What if the mood swings, the sleepless nights, the sudden irritation, and the loss of joy aren't signs that something is wrong with you…but signals that your biology is quietly staging a dramatic takeover? Kate Mason sits down with Dr. Joanna Bruce, GP of over 25 years, clinical director of Myma Health, and passionate advocate for women's hormonal wellbeing, to talk openly about perimenopause and menopause. Together they unpack why this decade-long hormonal shift is so often missed, dismissed, or misdiagnosed, and what women (and the people who love them) can actually do about it. From understanding the science of estrogen and progesterone fluctuation to debunking the damaging 2002 WHI study on HRT, this empowering conversation gives parents and partners the insight they need to understand what's really going on… in their bodies, their relationships, and their homes. Listen For2:00 What does the history of menopause research tell us about why women have been so underserved?8:20 How do you distinguish perimenopause symptoms from everyday exhaustion and stress?11:00 What are the early signs of perimenopause that women most commonly overlook?16:55 Is HRT actually safe, and why has the fear around it lasted more than two decades?25:10 What practical steps should women take if they think they are entering perimenopause? Leave a rating/review for this podcastwith one click  Connect with guest: Dr Joanna Bruce, GP & Clinical Director, Myma HealthWebsite | LinkedIn | Instagram Contact Kate:Email | Website | Kate's Book on Amazon | LinkedIn | Facebook | X

Health & Fitness Redefined
Menopause, Hormones and Real Answers With Dr. Vanessa Soviero

Health & Fitness Redefined

Play Episode Listen Later Feb 16, 2026 35:41


Send a textMenopause can feel like your body changed the rules without telling you. In this episode of The Anthony Amen Show, Anthony sits down with Dr. Vanessa Soviero, an OB GYN and certified menopause specialist, to cut through the confusion around hormones, weight gain, energy loss, and what actually works for women navigating menopause today. They discuss symptoms many people do not immediately connect to hormones such as joint pain, brain fog, skin changes, and stubborn belly fat, and why being told it will pass often leaves women struggling longer than necessary. Dr. Soviero breaks down common misconceptions from the WHI study, explains when hormone therapy may be appropriate, and explores evidence based nonhormonal options for women looking for real relief. The conversation also gets practical. Anthony and Dr. Soviero talk about strength training for bone density and metabolism, nutrition shifts that help manage cravings when sleep and hormones are disrupted, and how visceral fat and insulin resistance can change during midlife. You will also hear about creatine monohydrate, sleep strategies that can make a real difference, and why an individualized realistic plan matters more than chasing quick fixes.Beyond the science, they discuss real world challenges women face including limited time with providers, overwhelming supplement advice, and navigating health information online. If you have felt dismissed, confused, or unsure where to start, this episode offers a grounded honest conversation designed to help you move forward with clarity.Subscribe to The Anthony Amen Show for more conversations on fitness, health, and real world lifestyle change, and share this episode with someone who needs it.This episode is for women going through menopause and anyone who wants to better understand hormones, health, and how to support women during this stage of life.Support the showLearn More at: www.Redefine-Fitness.com

The Adult Chair
496: Brain Fog & The M-Factor: Tamsen Fadal on the Truth About Menopause

The Adult Chair

Play Episode Listen Later Feb 5, 2026 40:33


Today, I'm joined by Emmy-winning journalist and menopause advocate Tamsen Fadal, whose own unexpected journey through perimenopause and menopause led her to create a global movement of education, support, and empowerment for women. After years of brain fog, exhaustion, misdiagnosis, and silence from the medical system, Tamsen began using her voice and platform to help women understand what is happening in their bodies and how to advocate for real care. In this episode, we talk honestly about symptoms, hormones, relationships, sex, confidence, and why so many women feel blindsided by this transition. Tamsen brings clarity, humor, and compassion to a life stage that has been ignored for far too long, and she offers real guidance for women who want to feel informed, supported, and empowered. In this episode, we explore:  The symptoms most women miss in early perimenopause Why brain fog and sleep issues are among the most debilitating changes The impact of hormonal shifts on mood, libido, skin, hair, and body composition Misconceptions about estrogen, the WHI study, and hormone therapy The role of testosterone and why it is often a missing piece How to communicate with your partner about what you are experiencing Why advocating for yourself and finding an educated provider is essential   Resources from this Episode: Learn more about Tamsen Fadal: https://tamsenfadal.com Menopause Society Provider Finder: https://menopausesociety.org  Get Tamsen's book, "How to Menopause: Take Charge of Your Health, Reclaim Your Life, and Feel Even Better than Before"   MORE MICHELLE CHALFANT Website: https://www.michellechalfant.com Membership: The Adult Chair Collective https://www.michellechalfant.com/collective  Instagram: https://www.instagram.com/themichellechalfant Facebook: https://www.facebook.com/TheMichelleChalfant The Adult Chair® Facebook Group: https://www.facebook.com/groups/theadultchair YouTube: https://www.youtube.com/c/Michellechalfant

Brain Biohacking with Kayla Barnes
Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health

Brain Biohacking with Kayla Barnes

Play Episode Listen Later Jan 29, 2026 49:13


In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause.Kayla's social + website:Instagram:  kaylabarnesTikTok:  femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Jessica Shepherd's social + website:Website: https://www.jessicashepherdmd.com/Instagram: https://www.instagram.com/jessicashepherdmd/Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd

The Peter Attia Drive
#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.

The Peter Attia Drive

Play Episode Listen Later Jan 26, 2026 126:34


View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Lisa Mosconi is a world-renowned neuroscientist and the director of the Women's Brain Initiative at Weill Cornell Medicine, where she studies how sex differences and hormonal transitions influence brain aging and Alzheimer's disease risk. In this episode, Lisa explores why Alzheimer's disease disproportionately affects women and why longer lifespan alone does not explain their nearly twofold risk compared to men. She explains why Alzheimer's disease may be best understood as a midlife disease for women, beginning decades before symptoms appear, and how menopause represents a fundamental brain event that reshapes brain energy use, structure, and immune signaling. The conversation also examines what advanced brain imaging reveals about preclinical Alzheimer's disease, estrogen receptors in the brain, and why genetic risks such as APOE4 appear to affect women differently from men. Finally, Lisa discusses the nuanced evidence around menopause hormone therapy, the legacy of the WHI, her new CARE Initiative to cut women's Alzheimer's risk in half by 2050, and practical, evidence-based strategies to support brain health through midlife—including lifestyle, sleep, metabolism, mood, and emerging therapies such as GLP-1 agonists and SERMs (selective estrogen receptor modulators). We discuss: How Lisa's personal family history and scientific background led her to focus on the intersection of women's health, brain aging, and Alzheimer's disease (AD) [2:45]; The long preclinical phase of AD and the emotional burden carried by patients before dementia becomes severe [7:15]; How AD compares to other common forms of dementia: prevalence, pathology, symptoms, diagnostic challenges, and more [10:45]; Why AD disproportionately affects women: how AD is not simply a disease of old age or longevity but a midlife disease in which women develop pathology earlier [16:15]; Menopause as a leading explanation for women's increased Alzheimer's risk, and how advanced braining imaging can detect early changes in the brain [26:15]; How a new method for imaging estrogen receptors in the brain is changing how we think about the menopause transition [35:45]; What estrogen receptor imaging can and cannot tell us about hormone therapy's potential impact on brain health [48:45]; Lisa's studies on the relationship between levels of systemic estrogen and density of estrogen receptors in the brain [58:00]; Why blood estrogen levels poorly reflect brain estrogen signaling, and how tightly regulated brain hormone dynamics complicate our understanding of menstrual-cycle and lifestyle effects [1:02:15]; The CARE Initiative: Lisa's research program looking to slash AD rates in women [1:07:45]; The dramatic difference in AD risk between men and women associated with APOE4 [1:10:45]; What the evidence suggests about menopausal hormone therapy (MHT) and AD risk, and why timing, formulation, and uterine status appear to matter [1:12:00]; How the CARE initiative plans to study MHT and AD risk, within the practical constraints of a three-year research window [1:17:30]; How to think about starting hormone therapy during perimenopause: balancing symptom relief, hormonal variability, and individualized care [1:21:00]; Investigating selective estrogen receptor modulators (SERMs) as a targeted approach to brain health during and after menopause [1:25:00]; Why estrogen became wrongly associated with cancer risk and what the evidence actually shows [1:29:30]; Why better biomarkers are central to advancing women's Alzheimer's research [1:38:30]; Modifiable risk factors for dementia, the limitations of risk models, and questionable conclusions drawn from observational data [1:44:15]; GLP-1 agonists and brain health: exploring potential neuroprotective effects of GLP-1 agonists beyond metabolic benefits [1:49:00]; The importance of lifestyle factors in reducing risk of dementia: practical strategies for women to support brain health [1:53:45]; Why long-term, consistent lifestyle habits are essential for building cognitive resilience and protecting brain health over decades [2:01:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

The Optispan Podcast with Matt Kaeberlein
What Peter Attia Got Right About Ultimate Health (Rapidfire)

The Optispan Podcast with Matt Kaeberlein

Play Episode Listen Later Jan 17, 2026 32:02


Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/This is a reaction video on Peter Attia's 60-second health take, from carnivore diets and testosterone to seed oils and fasting. Matt provides nuanced medical commentary on where he agrees, disagrees, and adds crucial context that Attia's format couldn't include. Woven throughout is the surprising personal story of how Matt's 60 Minutes interview led to VIP New Year's Eve passes from Anderson Cooper, blending high-level health analysis with human connection. The episode debates headline health claims while sharing a once-in-a-lifetime NYC experience.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:Timestamps: 0:00 Cold open: rapid-fire takes (carnivore, testosterone, fasting, deodorant, etc.)0:42 Season 3 renewal + new year intro1:01 Holiday recap1:31 Times Square ball drop + Anderson Cooper passes (60 Minutes connection)3:33 Setup: reacting to Peter Attia's 60 Minutes “rapid fire”4:14 Multivitamin: “pass” (insurance policy vs evidence)5:01 Metformin: “definitely pass” for non-diabetics6:04 Seed oils: modest quantities likely not harmful6:27 Mouth taping: useful for some mouth breathers6:51 Bluetooth headphones + EMF: what we know vs what's uncertain8:32 Weighted vests vs rucksacks: does it matter?9:33 Carnivore diet: “very extreme”9:47 Heavy metal “detox”: snake oil vs real testing and interventions11:27 Food dyes: “deck chairs on the Titanic” (majoring in the minor)14:53 Microplastics: what to change, pragmatic exposure reduction18:47 Hormone replacement therapy (women): “crime of the century” + WHI fallout21:50 Testosterone for men: net positive, but abused/scamified23:16 Testosterone for menopausal women: emerging evidence + clinical reality25:37 Sleep tracking + wearables: helpful unless it creates anxiety26:23 Deodorant vs antiperspirant: aluminum concerns and skin irritation28:43 Non-stick pans / PFAS: relative risk and practical choices29:52 Intermittent fasting: protein risk + eating-disorder cautions31:39 Wrap-up + subscribe/comments outrohttps://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

Welcome to Wellness
#136 Exhausted? Brain Fog? Rage? Stop the Struggle - Dr. Deb Matthew

Welcome to Wellness

Play Episode Listen Later Jan 16, 2026 78:05


Are you feeling irritable, gaining weight, can't sleep, or struggling to hold it together? You might be having perimenopausal symptoms. Dr Deb shares how women over 30 can navigate fluctuating hormones and get back to feeling like themselves,

Thinking About Ob/Gyn
Episode 10.13 Estrogen, Free Birth, And Misinformation

Thinking About Ob/Gyn

Play Episode Listen Later Dec 25, 2025 62:47 Transcription Available


We unpack what WHI actually showed about estrogen-only therapy and breast cancer in light of new supporting data, then confront the free birth trend's preventable harms and the business model behind it. We share clear tools to spot false claims, review new aspirin data on preeclampsia, and outline twelve practical ways to cut waste in gyn surgery.• estrogen-only therapy associated with lower breast cancer diagnosis and mortality• combined estrogen plus progestogen neutralizing estrogen's protective signal• rare abdominal pregnancy case illustrating basic testing safeguards• free birth movement risks, censorship of bad outcomes, and money incentives• red flags in birth-related posts and the SIFT fact-checking method• four quick filters to vet social content before sharing• nuanced view on aspirin for preeclampsia with mixed trial evidence• twelve surgical sustainability steps that save cost and reduce wasteBe sure to check out thinkingaboutobgyn.com for more information and be sure to follow us on Instagram1:11 Estrogen Therapy And Breast Cancer Risk6:41 What WHI Actually Showed11:22 Progesterone, HRT Fads, And Risks15:35 Wild Case: Abdominal Pregnancy Behind Tumor20:42 Free Birth Trend And Tragic Outcomes25:37 How The Misinformation Business Works30:10 Red Flags In Birth Content Online35:10 The SIFT Method For Fact-Checking40:20 Four Tips To Vet Social Posts46:25 Live Walkthrough: Debunking A Viral Post52:40 Digital Hygiene And Curating Feeds56:48 Aspirin For Preeclampsia: Mixed EvidenceFollow us on Instagram @thinkingaboutobgyn.

The Curbsiders Internal Medicine Podcast
#507 Swinging the Pendulum on Menopause Care With Dr Rachel Rubin

The Curbsiders Internal Medicine Podcast

Play Episode Listen Later Dec 8, 2025 94:31


Transform your approach to menopause care with the latest evidence and expert insights you can use tomorrow. Learn how to move beyond outdated WHI-era fears and confidently prescribe individualized, effective hormonal therapies. We're joined by urologist and sexual medicine specialist Dr Rachel Rubin (@DrRachelRubin), who brings clarity, practicality, and a fresh perspective to this rapidly evolving field. Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Intro Case Shifting care for menopause WHI/black box warning labels What makes you nervous? Local vaginal treatments Progesterone therapy Estrogen therapy Testosterone therapy Perimenopause Outro Credits Producer, Writer, Show Notes, Infographic, Cover Art: Molly Heublein MD Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP; Molly Heublein MD Reviewer: Leah Witt MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Rachel Rubin MD Disclosures Dr. Rachel Rubin reports financial support from Sprout Pharmaceuticals . The Curbsiders report no relevant financial disclosures.  Sponsor: Aura Frames  For a limited time, save on the perfect gift by visiting AuraFrames.com to get $35 off Aura's best-selling Carver Mat frames by using promo code CURB at checkout.  Sponsor: Bucksbaum-Siegler Institute If you want to learn more about what the Bucksbaum-Siegler Institute is doing and to nominate someone for the Clinical Excellence Award visit bucksbauminstitute.uchicago.edu. Sponsor: Mint Mobile   Shop Mint Unlimited Plans at MINTMOBILE.com/CURB.  Sponsor: Panacea Financial Visit bit.ly/PFCURB to connect with a physician-focused banker and get your finances  moving in the right direction

Inside the Cure with Dr. Charles Mok
FDA Updated Guidance on Estrogen Therapy: What Women Should Know

Inside the Cure with Dr. Charles Mok

Play Episode Listen Later Nov 28, 2025 36:08


The FDA has updated its stance on estrogen therapy, reversing decades of confusion from early WHI interpretations. New research and global data now show estrogen may support long-term health and reduce key chronic risks.This episode explains the FDA's updated guidance, what the WHI got wrong, and what current science reveals about heart health, brain function, diabetes risk, bone density, and breast cancer. We also break down synthetic progestins vs. bioidentical progesterone, why timing matters, and how Europe achieved better outcomes with HRT.Tune in to get clear, evidence-based insights so you can talk confidently with your provider and decide if hormone therapy fits your goals.Timestamps: 00:00 FDA Update 00:27 WHI Misinterpretation 01:05 Synthetic vs Bioidentical 02:14 Why Estrogen Was Blamed 03:12 Black Box Warning 04:48 New Research 06:10 Heart/Brain/Cancer Data 07:45 Europe's Approach 08:30 Progestins vs Progesterone 09:45 What It Means Today 10:45 Why Doctors Stopped HRT 11:30 FDA 2025 Review 12:28 Black Box Removal 13:25 Key Takeaways 14:05 How to Discuss HRTReady to talk through your options? Visit this link to learn more:https://www.alluremedical.com/Subscribe to the podcast and leave a 5-star review!Read the latest research and advice from the doctors at Allure Medical: https://www.alluremedical.com/books/ Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/ Instagram: https://www.instagram.com/alluremedicals/ Website: https://www.alluremedical.com/ YouTube: https://www.youtube.com/@AllureMedical TikTok: https://www.tiktok.com/@alluremedical  Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true Join the Allure Medical Inner Circle Membership:https://www.alluremedical.com/inner-circle-membership/ 

Ground Truths
Jennifer Gunter & Eric Topol: Discuss Women's Health and Recent Changes by FDA for MHT

Ground Truths

Play Episode Listen Later Nov 28, 2025 60:50


A couple of weeks ago, the FDA Commissioner published a WSJ oped “The FDA Liberates Women's Hormone Replacement Therapy” (←gift link) and, with other FDA colleagues, a JAMA essay entitled “Updated Labeling for Menopausal Hormone Therapy” (open-access). That change, and the data cited, led to a series of articles in the days that followed, such as at STAT News “FDA reverses decades-old warning on hormone therapy products for menopause. Agency says the treatments o!fer heart, brain, and bone health benefits” and at the Washington Post “The FDA finally corrects its error on menopause hormone therapy. Women have been needlessly scared away from effective treatments.” If you read through these links, you'll be confused. Does MHT have proven cognitive benefits? What about a study from 1991 that showed ~50% reduction of fatal heart events with MHT? Or the 35% decreased risk of Alzheimer's disease? Or the breast cancer increased risk attributed to medroxyprogesterone acetate?I turned to my go-to gynecologist truth teller, Dr. Jen Gunter, to get her review of the evidence. This is a complex topic, with old data from the 2002 Women's Heath Initiative (WHI), new reports since, population level analysis, changes in preparations of MHT including local delivery, and much more.Here is our conversation which isn't just about MHT but includes “Big Wellness” marketing direct to middle aged women, the new FDA approved drug for hot flashes, the $14 million cut of the NIH's Office of Women's Health , marked increase in philanthropic support of women's health research, the Surgeon General nominee, ovarian failure, and a lightning round on proven benefits of MHT.Here's a brief clip on her views of the women's health “wellness” predatorsWe also discussed the reasons for Dr. Gunter's planned move next year back to Canada after practicing gynecology for 3 decades in the United States. I referred to a recent GT I wrote about the WHI and the potential favorable impact of MHT on the immune system, as suggested by new data on organ clocks. That finding, which has been replicated, may be linked to healthy aging, extending healthspan.****************************Thanks to the >190,000 Ground Truths subscribers from every US state and 210 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile.If you found this interesting PLEASE share it!Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.Thank you Debbie Weil, Cynthia Brumfield, Sara Garcia, Harshi Peiris, Ph.D., Liane Moccia, and over 1,000 others for tuning into my live video with Dr. Jen Gunter! Join me for my next live video in the app. Get full access to Ground Truths at erictopol.substack.com/subscribe

Ever Forward Radio with Chase Chewning
EFR 910: Muscle, Menopause & Metabolism - The Hidden Health Crisis Impacting Every Woman After 40 with Dr. Jessica Shepherd

Ever Forward Radio with Chase Chewning

Play Episode Listen Later Nov 24, 2025 86:17


This episod is brought to you by Cured Nutrition, Caldera Lab and Joi & Blokes. Dr. Jessica Shepherd—OB/GYN, clinical advisor for P-Volv, and author of Generation M—breaks down everything women need to know about perimenopause, menopause, and longevity. She explains why mindset is the foundation of midlife health, how declining estrogen affects every organ system, why only 8% of symptomatic women ever receive a diagnosis, and how common comorbidities rise 45% or more between ages 40–59. Dr. Shepherd shares science-backed strategies for navigating symptoms, improving metabolic and mitochondrial health, understanding the truth about hormone therapy after the flawed WHI study (which led to an 82% decline in prescriptions), and using exercise, protein, and muscle-building to protect cognition, heart health, and overall vitality. Whether you're a woman entering midlife—or a partner wanting to better support her—this conversation is a masterclass in women's health, empowerment, and aging well. Follow Jessica @jessicashepherdmd Follow Chase @chase_chewning ----- 00:01 - Intro & shocking stats: women live longer but spend more years in poor health; HRT prescriptions dropped 82% after 2002 00:28 - Muscle as the organ of longevity; women lose 3–5% per decade, accelerated after menopause 01:18 - Why estrogen decline shifts the whole body; Dr. Shepherd introduces herself and her mission in women's health 02:15 - Redefining women's health & longevity; why women aren't thinking about longevity soon enough 04:23 – Mindset, habits, and community as the foundation of midlife health 07:13 - Barriers to staying well: socioeconomic factors, upbringing, access, and misconceptions about wellness 09:33 - Women's current wellness landscape; societal expectations, caregiving burden, and systemic gaps 12:46 – Major healthcare gaps: lack of research, exclusion of women from clinical studies until the '70s, and only 3% of VC health funding going to women 17:30 – Pharma eliminating women's health divisions; downstream effects on innovation and access 19:10 – Perimenopause 101: defining terms, symptoms vs. cycles, 34+ possible symptoms, and why diagnosis is trick 24:45 – The cardiovascular danger of estrogen decline; heart disease as the #1 killer of women 27:02 – Stress vs. perimenopause symptoms; mood disorders peak between 45–55 29:48 – How HRT has evolved in the last 10–20 years; symptom relief and longevity benefits 32:32 – Why only 5% of women are on hormone therapy today; misconceptions and new guidelines 34:20 – WHI study deep dive: media panic, misinterpretation, lack of statistical significance, and lasting fear 39:06 – Risk vs. benefit: how to think about HRT decisions with your provider 41:51 – Chase shares his TRT story; quality of life, fertility considerations, and hormone literacy 45:16 – Dr. Shepherd's personal hormone story: cognition issues, testosterone, and starting estrogen at 46 48:12 – Supplements Dr. Shepherd uses: Vitamin D, creatine, CoQ10, Urolithin A 50:10 – Muscle, mitochondrial health, sarcopenia & glucose control: why resistance training is non-negotiable 52:25 – Movement, neuroplasticity, balance & cognition: why staying active protects the aging brain 55:12 – How partners can best support women in perimenopause: emotional support & shared routines 57:52 – The science of emotional support: social connection decreases pain, inflammation, and improves outcomes 59:22 – Menopause explained: average age, symptom timeline, and the hidden cellular changes 01:02:39 – Nutrition, glucose control, protein needs, alcohol & sugar intake, and metabolic health 01:07:07 – Protein requirements (1.0–1.2g/kg), resistance training, and why women must build muscle 01:09:37 – U.S. data: 55%+ of women report symptoms; only 8% diagnosed; why doctors miss it 01:12:34 – Which providers are best for menopause care & what certifications to look for 01:15:31 – Comorbidities rise 45% between 40–59: hypertension, thyroid, arthritis, sleep disorders & estrogen's role 01:18:25 – Is biohacking menopause possible? Current limits + ovarian longevity research 01:22:24 – Exercise as the ultimate biohack; sustainable movement for aging wel 01:23:19 – Final Q: How Dr. Shepherd lives Ever Forward — flexibility, pause, and growth ----- Episode resources: 20% off DREAM gummies with code EVERFORWARD at CuredNutrition.com/everforward 50% off any product or diagnostic labs with code CHASE at JoiAndBlokes.com/chase 20% off any men's skincare product with code EVERFORWARD at CalderaLab.com Watch and subscribe on YouTube

Hack My Age
Long Standing Menopause Doctor Explains Estrogen and Cancer Risk - Dr. Lindsey Berkson

Hack My Age

Play Episode Listen Later Nov 21, 2025 81:06


Are you still confused (or totally terrified) about hormone therapy because of what you heard that it causes cancer? Do you have breast cancer and have been told you cannot take hormone therapy, but still question if this is true? Then this episode is for you. Today I sit down with cancer survivor Dr. Lindsey Berkson, one of the most outspoken, evidence-driven voices in hormone science. She has been on the front lines for more than 40 years, challenging misinformation, teaching clinicians, and calling out the myths that have held women back from lifesaving care. We cover: What really happened in the 2002 WHI study and why the press release created global panic Why estrogen may be breast-protective…even for breast cancer patients What the 2024 NIH study of 10 million women revealed about HRT Why not ALL estrogen is proliferative The discovery of ER-beta and how it reframed estrogen's role in cancer biology What 25 human trials show about HRT use in ER+ breast cancer survivors What is oxytocin and how does this hormone help women in menopause   Dr. Lindsey Berkson is a pioneer in hormone and nutritional health with over four decades of clinical and research experience. She's triple board-certified in nutrition, a hormone scholar at Tulane University's estrogen think tank, and one of the first practitioners to bridge endocrinology, nutrition, and gut health into an integrated approach to healing. She's also the author of more than 20 books, including Hormone Deception and Healthy Digestion the Natural Way, and has developed physician-formulated nutraceutical lines and patented bioidentical hormone applications.   New book: Oxytocin Medicine https://amzn.to/3JWdDAm Recommended Reading: Hormones 101 by Dr. Jeffrey Dash Courses: https://drlindseyberkson.com/courses/ Contact Dr. Lindsey Berkson Website: https://drlindseyberkson.com/ Instagram: @dlberkson https://www.instagram.com/dlberkson/ Facebook: @Dr.LindseyBerkson https://www.facebook.com/Dr.LindseyBerkson/ Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here - https://vitaliskincare.com Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - http://oxfordhealthspan.com/discount/ZORA Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com - https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠     Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠   Biohacking Menopause Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠    For partnership inquiries: https://www.category3.ca/  For transparency: Some episodes of Hack My Age are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.  

The Sacred Purpose Podcast
49. [CVOH] HRT, Menopause and Leadership: Women's Health Equity & Harnessing Community, With Liz Powell, Esq. MPH

The Sacred Purpose Podcast

Play Episode Listen Later Nov 18, 2025 44:11


Whether you're looking for hope, practical advocacy tips, or updates on current legislation, you'll find inspiration in how collective action—powered by real stories—can fuel progress. Stay tuned for an uplifting, honest, and actionable conversation that's helping shape the future of women's health. This episode with Liz Powell, hosted by Lisa Malia covers timely topics like the FDA's recent announcement about hormone therapy, the vital work of the Breast Cancer Early Detection Coalition, and accessible ways anyone can join the movement for better health outcomes. TIMESTAMPS: 00:00 Women's Health Advocacy Network 05:28 Holistic Women's Health Advocacy 08:21 "Empowerment Through Advocacy Stories" 09:49 Hormone Therapy Misunderstood in WHI 15:43 Staying Hopeful Amid Overwhelm 17:09 "Easy Steps to Advocacy" 19:56 "Change Starts Within Us" 23:26 "2024: Women's Health Revolution" 28:49 Supplemental Breast Cancer Screening 30:30 "Fighting for Double Mastectomy" 36:19 Advocacy Secures Funding Success 39:52 "Open, Agile, Impactful Leadership" 41:26 "Grateful to Be Involved"   LEARN MORE:  The Clear Pathways Program: https://www.breastdensitysummit.org/ The Breast Density Summit: https://www.breastdensitysummit.org/webinar-registration MAKE A DONATION: https://www.paypal.com/donate?hosted_button_id=NJMF86A8Y9RJQ Follow LISA MALIA LinkedIn: https://www.linkedin.com/in/lisamalianorman/   WOMEN'S HEALTH ADVOCATES: https://womenshealthadvocates.org/ BREAST CANCER EARLY DETECTION COALITION: https://womenshealthadvocates.org/bcedc/ G2G CONSULTING: https://www.g2gconsulting.com Follow LIZ POWELL LinkedIn: https://www.linkedin.com/in/liz-powell-507b135/   Liz is Founder of G2G Consulting, which creates and implements government to growth (G2G) strategies for clients—securing $550 million since 2007. We advance health and high-tech innovation for businesses and nonprofits by accessing non-dilutive funding, shaping policies and regulations, and building relationships with key decision-makers. Liz founded the Women's Health Advocates, which is in all 50 states and has organized the first-ever Women's Health Capitol Hill Day on May 21, 2025, the Breast Cancer Early Detection Coalition Hill Day on July 16, 2025, Congressional Briefings and online forums, advocacy letter-writing campaigns, the drafting of legislative language, and grassroots mobilization events across the country. Previously, she served as Legislative Director in Congress where she staffed the Congressional Caucus for Women's Issues, Armed Services Committee and Small Business Committee and served as a Policy Analyst for UK Parliament's Health Committee as well as congressional and presidential political campaign staff. She has received the Woman Entrepreneur of the Year Award and Women of Achievement Award and earned her MPH from Harvard, JD from George Washington, and BA from Colgate.

Back to The Basics
84: Stop Normalizing Painful Periods – How to Finally Fix Hormone Imbalance with Dr. Shawn Tassone

Back to The Basics

Play Episode Listen Later Nov 9, 2025 60:02


>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠

The Functional Gynecologist
#266 Why Conventional Gynecology Misses Midlife Health And What To Do Instead

The Functional Gynecologist

Play Episode Listen Later Oct 27, 2025 32:25 Transcription Available


We challenge the band-aid approach to women's midlife health and show how faith and functional medicine uncover root causes behind hormones, fatigue, and heavy periods. We separate myth from evidence on HRT and give clear first steps to advocate for lasting change.• why conventional gynecology misses upstream causes• burnout, back pain, and a pivot to functional medicine• the mindset shift from insurance-driven fixes to real healing• heavy periods, IUD risks, and synthetic progestin concerns• functional medicine's timeline and root-cause method• estrogen versus progestins and WHI study context• safer, bioidentical HRT paired with lifestyle repair• practical first steps to self-advocacy and hope• inviting God into the healing journeyCHECK OUT THE ENTIRE MIDLIFE RESET SUMMIT!! https://midliferesetsummit.com/Did you know over 6,000 women enter menopause every single day in the U.S. ? The medical system isn't helping them heal at the root — and that's where faith-based coaches come in.

Hear From Her: The Women in Healthcare Leadership Podcast Series
Voices of Change: Women Leading the Menopause Movement

Hear From Her: The Women in Healthcare Leadership Podcast Series

Play Episode Listen Later Oct 13, 2025 44:48


Why is menopause care still fragmented? Dr. Alyssa Dweck, Dr. Mary Jane Minkin, and Heather Maurer dig into the “menopause desert,” the WHI legacy, workplace fixes, and how NPs and clinicians can personalize evidence-based care—without the stigma or misinformation. This podcast is not available for CME/CE/CPD credits. Please visit the Medscape homepage for accredited CME/CE/CPD activities. Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002974?ecd=bdc_podcast_libsyn_mscpedu

movement voices menopause nps women leading medscape whi change women alyssa dweck mary jane minkin
Modern Medicine Movement
The TRUTH about MENOPAUSE and (HRT) Hormone Replacement Therapy

Modern Medicine Movement

Play Episode Listen Later Oct 9, 2025 42:37


In this episode, Dr. Thomas Hemingway will share the TRUTH on Menopause and HRT and the shocking data that was erroneously misinterpreted back in 2002 (WHI) which sadly singlehandedly decreased the use of HRT and what these data and recent data ACTUALLY show about Menopause and HRT use.  This will blow your mind because it may be exactly opposite to what you have heard...Take a Listen and please Share with a Friend!*ACCESS my FREE workshop, "Younger, Stronger, for Longer!"  How to turn back your biological age 10-20 years so you can do the things you want to do that you no longer thought possible due to your age.  Perform at your best and live your best life!*And, in my new Performance, and Longevity medical practice we specialize in turning back your biological age and OPTIMIZING HORMONES so you can feel a decade or more younger so you can do the things you want to do that you thought were no longer possible due to your age.  Join the waitlist here!SHARE with a Friend and please drop a Review:)*Don't wait to Prioritize your health, Start Today with the Simple and Powerful Steps detailed in my Best-selling book.*GET DIRECT ACCESS to DR. HEMINGWAY in these AMAZING COURSES!**Free resource: 'The truth about GLP-1s and their alternatives' - https://drthomashemingway.myflodesk.com/n1yyjkcb68Mahalo and Aloha andTo your health,

Inside Boxing Live
412 | Canelo-Crawford voicemail predictions

Inside Boxing Live

Play Episode Listen Later Sep 8, 2025 56:58


This episode is brought to you by PPV.COM! (0:00) - Intro (5:00) - Canelo's cousin calls in (7:07) - Can we truly judge Crawford from the Madrimov fight? (12:12) - 10 year old Miles picks Canelo by decision (15:11) - Can Canelo stop Crawford? (19:20) - Whi has the psychological edge? (26:25) - Is Crawford cherry picking Canelo for the money? (32:20) - Will Crawford go out on his shield unlike Charlo? (39:18) - The body work of Crawford (42:35) - Are Mexicans picking against Canelo? (45:30) - Could a draw be possible to set up the rematch? (47:20) - Algieri's advice for each man (51:44) - Undercard info Learn more about your ad choices. Visit megaphone.fm/adchoices

Hack My Age
Should We Delay Menopause? What Extending Ovarian Life Means for How We Age - Lizellen LaFollete

Hack My Age

Play Episode Listen Later Sep 1, 2025 60:14


Did you know that your ovaries are so much more than just for making babies? They don't just die after menopause and today we are going to learn so much more about their function, HRT and so much more with California OB-GYN Dr. Lizellen LaFollette We cover: How she treated her patients after the WHI came down with the headlines that estrogen causes cancer…which btw, it doesn't What her vision is for the future of menopause research and treatments for women What she learned at the Buck Institute of Aging through her research on ovarian aging And so much more Dr. Lizellen LaFollette is a board-certified OB-GYN with more than three decades of experience caring for women in the Bay Area in obstetrics, gynecology, menopause and aesthetics. Based in Greenbrae, California, she is known for her leadership in minimally invasive gynecologic surgery. In addition to her clinical practice, Dr. LaFollette has been an investigator and advisor for multiple studies in women's health, including research on preterm labor risk, inflammation biomarkers, and reproductive longevity through her work with the Buck Institute's Reproductive Longevity Consortium.  She is so often voted “Top Doctor” by her local journals. And is committed to evidence-based, patient-centered care. Her areas of focus include menopause management, reproductive aging, and reducing unnecessary cesarean sections, while continuing to integrate the latest innovations to improve women's health across the lifespan. You're going to love this conversation CONTACT Email: office@drlafollette.com Instagram: https://www.instagram.com/drlafollette/ Website: https://drlafollette.com   Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050 Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before October 1, 2025 to win a Flexbeam Red Light Therapy Device. Or save 10% with code ZORA at recharge.health   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠       Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠  Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠   

Hack My Age
From Patches to Pills: A Guide To Understanding Your HRT (Hormone Therapy) Choices - Zora Benhamou

Hack My Age

Play Episode Listen Later Aug 29, 2025 52:54


What does HRT mean and how do I choose the formula that's right for me? In this solo episode, I'm unpacking one of the most confusing parts of hormone therapy: the different delivery methods. From patches to pills to creams, I'll walk you through what's bioidentical, what isn't, and what you really need to know to make informed choices. We cover: Why the WHI study scared a generation of women and what it really showed The difference between FDA- and EMA-approved, compounded, bioidentical, and synthetic hormones The 3 types of natural estrogen (E1, E2, E3) and how they're used in therapy Oral estrogen and progesterone: pros, cons, and brand examples Transdermal patches, gels, creams, and sprays and which women like the most Cost and access: NHS, FDA, EMA, compounded, and private prescriptions By the end, you'll have a clear picture of the safest and most effective delivery methods, so you can feel confident talking to your doctor about what's right for you. Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here https://vitaliskincare.com Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050 Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before October 1, 2025 to win a Flexbeam Red Light Therapy Device. Or save 10% with code ZORA at recharge.health   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠     Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠  Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠  

Ending Physician Overwhelm
Who Will You Learn From?

Ending Physician Overwhelm

Play Episode Listen Later Aug 26, 2025 36:59


Send us a textWelcome back to Ending Physician Overwhelm! As we head into the last week of August 2025 and prepare for back-to-school season, it's time to think about something we do constantly as physicians: learning.The Evolution of Medical LearningYou've been a professional learner your entire career. Medical school, residency, fellowship, boards, CME requirements - you've mastered the art of absorbing information and passing tests. But here's the question that might change everything: Who are you actually learning from?If you're like most of us who trained in the early 2000s, your medical education came primarily from older white men reading the same traditional journals and following conventional pathways. While this wasn't inherently wrong, it created a narrow lens that may no longer serve you - or your patients.Breaking Out of Traditional Learning BoxesAs medicine evolves, so should your sources of knowledge. Whether you're exploring:Obesity medicine (where traditional training left massive gaps)Menopause care (practically non-existent in most curricula thanks to the WHI study fallout)Lifestyle medicine approachesNew practice models that prioritize patient connectionYou need voices that reflect the reality of modern healthcare delivery, not just academic theory.The Current Medical Learning LandscapeHere's what's happening right now that affects how you learn:Traditional resources are under threat: With political forces dismantling institutions like ACIP and creating uncertainty around CDC guidance, you're losing historically reliable sources of information.AI is changing everything: Your residents and students are using AI tools that you may not fully understand, yet you're expected to guide them safely through this new landscape.Diversity of voices matters: The patients you serve come from all backgrounds - shouldn't your teachers reflect that diversity too?Finding Your New Learning PathAsk yourself these critical questions:Who is doing the work the way you want to do it?Are you open to being challenged and learning new approaches?Can you unlearn outdated information that's no longer serving your patients?How will you vet new sources of information in an era of compromised traditional resources?Practical Steps for Better LearningSeek out practitioners who:Are actively treating patients (not just publishing papers)Offer practical, real-world applicationsDiscuss the full picture including costs, side effects, and patient experienceChallenge traditional approaches with evidence-based alternativesConsider learning formats beyond traditional CME:Podcasts from practicing physiciansCourses from specialists doing the workMentorship from independent practitionersBooks and resources from diverse voices in medicineThe Power Support the showTo learn more about my coaching practice and group offerings, head over to www.healthierforgood.com. I help Physicians and Allied Health Professional women to let go of toxic perfectionist and people-pleasing habits that leave them frustrated and exhausted. If you are ready to learn skills that help you set boundaries and prioritize yourself, without becoming a cynical a-hole, come work with me.Want to contact me directly?Email: megan@healthierforgood.comFollow me on Instagram!@MeganMeloMD

Dr. Chapa’s Clinical Pearls.
HRT "Black Box" Warning: Time To Go

Dr. Chapa’s Clinical Pearls.

Play Episode Listen Later Aug 15, 2025 30:38


There's a lot of fear and misinformation around HRT, and one of the biggest myths is that HT is a highly significant cause of breast cancer. That is not the case. This is a remnant concept from 2002, with MANY caveats. Calls for the removal of the black box warning on hormone replacement therapy (HRT) stems primarily from the outdated and limited nature of the data from the Women's Health Initiative (WHI) study published in 2002. The WHI, while groundbreaking at the time, focused predominantly on a specific formulation of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) in older, postmenopausal women, leading to concerns about its generalizability to the broader population of women considering HRT. This is why on July 17, 2025, the FDA met with a panel of experts, in open forum, to hear the petition of removing the black box warning on hormone replacement therapy. Listen in for details. 1. Writing Group for the Women's Health Initiative Investigators. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial. JAMA.2002;288(3):321–333. doi:10.1001/jama.288.3.3212. Manson JE, Crandall CJ, Rossouw JE, Chlebowski RT, Anderson GL, Stefanick ML, Aragaki AK, Cauley JA, Wells GL, LaCroix AZ, Thomson CA, Neuhouser ML, Van Horn L, Kooperberg C, Howard BV, Tinker LF, Wactawski-Wende J, Shumaker SA, Prentice RL. The Women's Health Initiative Randomized Trials and Clinical Practice: A Review. JAMA. 2024 May 28;331(20):1748-1760. doi: 10.1001/jama.2024.6542. PMID: 38691368.3. NAMS: The 2022 hormone therapy position statement of The North American Menopause Society (Menopause)

Perimenopause Simplified
Caring for Aging Parents While Navigating Perimenopause: What No One Talks About

Perimenopause Simplified

Play Episode Listen Later Aug 6, 2025 11:19


In this episode of Perimenopause Simplified, Claudia opens up about a side of midlife that rarely gets discussed: what it's really like to care for aging parents, while navigating your own hormone shifts, emotions, and identity. She shares a personal story about supporting her mom after hip surgery, how losing her dad shaped her perspective on forgiveness, and why so many women in their 70s are now facing serious health issues, due to the fallout of the WHI study and lack of hormone therapy access. Claudia also talks about the hard (but necessary) conversation she had with her mom about end-of-life planning…and why getting clear now can prevent stress and heartache later.  A raw, reflective episode that will hit home for any woman feeling the weight of midlife caregiving and a powerful reminder to take care of your health now.   In this episode, Claudia discusses: The emotional and physical demands of midlife caregiving Why she chose to forgive her father before he passed and what that taught her The ripple effects of the WHI study on women's health and quality of life Stats on bone loss, dementia, sleep issues & metabolic decline in women over 40 The evolving relationship with her mom: from frustration to compassion How planning ahead for death can make space for grieving, instead of chaos   Sources: Alzheimer's Facts Osteoporosis Stats Prevalence of Obesity Musculoskeletal Syndrome of Menopause Sleep During Menopause Menopause and Cardiovascular Disease Risk   CONNECT WITH CLAUDIA:  Website YouTube Instagram Facebook   FREE RESOURCES:  Peri-What?! The Must-Have Guide for Women 40+ Navigating Hormone Changes Perimenopause Daily Checklist HRT 3-Day Crash Course   GET SUPPORT:  Perimenopause Clarity Session The Perimenopause Method Program Perimenopause HRT Roadmap Course   QUESTIONS?  Email: claudia@claudiapetrilli.com   LOVE THE SHOW? Please subscribe, leave a 5-star rating, review, and share, so that other women can find this podcast for guidance and support through perimenopause!   

Perimenopause Simplified
72. When Should You Start HRT? The Truth for Women in Their 40s

Perimenopause Simplified

Play Episode Listen Later Jul 23, 2025 9:32


Confused about when to start hormone replacement therapy? You're not alone. In this episode of Perimenopause Simplified, we're cutting through the mixed messages and breaking down when to consider starting HRT, what symptoms to look out for, and how to know if it's the right move for you. If you're in your 40s and feeling dismissed, overwhelmed, or unsure where to begin…this one's for you. We cover: Why hormone replacement therapy (HRT) is so confusing and what's changed since the 2002 WHI study The difference between perimenopause and menopause & why that matters for HRT timing Common early symptoms that may signal hormone shifts (and which hormone to start with first) When estrogen might be added - it's earlier than you think The risks of waiting too long to start HRT Why and when I started HRT myself   Sources: Hormone Therapy & Cardiovascular Disease: The Role of Timing Hormone Therapy & Cognition Prevention of Osteoporosis NAMS Hormone Therapy Position   To learn about hormone therapy, grab Claudia's brand new, FREE resource: 3-Day HRT Crash Course. In just 3 quick emails, you'll learn:

BackTable Urology
Ep. 246 Hormone Replacement Therapy in Menopause: Risks, Benefits, and Myths Debunked with Dr. Kelly Casperson

BackTable Urology

Play Episode Listen Later Jul 8, 2025 51:37


Menopause isn't just a diagnosis—it's a transition, and the way we treat it needs to change. Dr. Kelly Casperson joins Dr. Suzette Sutherland in this urogynecology crossover episode of BackTable to challenge outdated beliefs about menopause and hormone replacement therapy (HRT). They revisit the impact of the 1990s Women's Health Initiative (WHI) study and explain how its findings—especially around synthetic hormones—were widely misinterpreted and continue to adversely influence patient and provider decisions today. --- SYNPOSIS Dr. Casperson breaks down the differences between the hormones used in WHI and the safer, more targeted options available today. The conversation explores the broad benefits of modern HRT, including reduced risks of cardiovascular disease, osteoporosis-related fractures, and even dementia. Beyond the science, the episode also addresses the urgent need for better medical education and updated guidelines around menopause care.Dr. Casperson and Dr. Sutherland make the case for empowering patients through informed consent and better clinician training. They also discuss Dr. Casperson's upcoming book, The Menopause Moment, which aims to equip women with the tools and knowledge to navigate this life stage with confidence. --- TIMESTAMPS 00:00 - Introduction02:50 - Focus on Menopause and Hormone Replacement Therapy04:20 - The Women's Health Initiative (WHI) Study05:39 - Understanding Risks and Misconceptions12:43 - Reevaluation of the Women's Health Initiative Study18:31 - Impact of Media and Physician Education19:58 - Current State of Hormone Therapy22:17 - Broader Implications and Future Directions27:17 - Evaluating FDA Warnings and Gender Bias in Hormone Treatments29:49 - The Impact of Hormone Therapy on Women's Health32:11 - Risks of Not Using Hormones35:44 - Hormones and Brain Health: Debunking Myths40:41 - The Timing Hypothesis and Long-Term Hormone Use46:32 - Advocacy and Education for Menopause Awareness48:04 - Conclusion and Upcoming Resources --- RESOURCES PBS: The M Factor: Shredding the Silence on Menopause:https://www.pbs.org/show/the-m-factor-shredding-the-silence-on-menopause/ The Menopause Moment by Dr. Kelly Casperson: https://kellycaspersonmd.com/the-menopause-moment-book/ Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer's disease and dementia:https://pmc.ncbi.nlm.nih.gov/articles/PMC10625913/

BackTable OBGYN
Ep. 88 Hormone Replacement Therapy in Menopause: Risks, Benefits, and Myths Debunked with Dr. Kelly Casperson

BackTable OBGYN

Play Episode Listen Later Jul 8, 2025 52:02


Menopause isn't just a diagnosis—it's a transition, and the way we treat it needs to change. Dr. Kelly Casperson joins Dr. Suzette Sutherland in this urogynecology crossover episode of BackTable to challenge outdated beliefs about menopause and hormone replacement therapy (HRT). They revisit the impact of the 1990s Women's Health Initiative (WHI) study and explain how its findings—especially around synthetic hormones—were widely misinterpreted and continue to adversely influence patient and provider decisions today. --- SYNPOSIS Dr. Casperson breaks down the differences between the hormones used in WHI and the safer, more targeted options available today. The conversation explores the broad benefits of modern HRT, including reduced risks of cardiovascular disease, osteoporosis-related fractures, and even dementia. Beyond the science, the episode also addresses the urgent need for better medical education and updated guidelines around menopause care.Dr. Casperson and Dr. Sutherland make the case for empowering patients through informed consent and better clinician training. They also discuss Dr. Casperson's upcoming book, The Menopause Moment, which aims to equip women with the tools and knowledge to navigate this life stage with confidence. --- TIMESTAMPS 00:00 - Introduction02:50 - Focus on Menopause and Hormone Replacement Therapy04:20 - The Women's Health Initiative (WHI) Study05:39 - Understanding Risks and Misconceptions12:43 - Reevaluation of the Women's Health Initiative Study18:31 - Impact of Media and Physician Education19:58 - Current State of Hormone Therapy22:17 - Broader Implications and Future Directions27:17 - Evaluating FDA Warnings and Gender Bias in Hormone Treatments29:49 - The Impact of Hormone Therapy on Women's Health32:11 - Risks of Not Using Hormones35:44 - Hormones and Brain Health: Debunking Myths40:41 - The Timing Hypothesis and Long-Term Hormone Use46:32 - Advocacy and Education for Menopause Awareness48:04 - Conclusion and Upcoming Resources --- RESOURCES PBS: The M Factor: Shredding the Silence on Menopause:https://www.pbs.org/show/the-m-factor-shredding-the-silence-on-menopause/ The Menopause Moment by Dr. Kelly Casperson: https://kellycaspersonmd.com/the-menopause-moment-book/ Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer's disease and dementia:https://pmc.ncbi.nlm.nih.gov/articles/PMC10625913/

The Humble Skeptic
How Did Jesus View the Old Testament?

The Humble Skeptic

Play Episode Listen Later May 19, 2025 40:30


After his resurrection, Luke 24 records that Jesus walked with two of his disciples on the road to Emmaus, and during that journey, we're told that “Beginning with Moses and all the Prophets, he interpreted to them in all the Scriptures the things concerning himself.” So what OT passages did Jesus likely have in mind as he discussed the Hebrew Bible with these two disciples? Joining me to discuss this question is Jason DeRouchie, research professor of Old Testament and Biblical Theology at Midwestern Baptist Theological Seminary and the author of How to Understand and Apply the Old Testament.SPECIAL OFFER — If you make a GIFT of any size or upgrade to a PAID subscription, we'll send you a “pre-release” PDF copy of Shane's forthcoming book, Luke's Key Witness.SHOW NOTESBooks40 Questions About Biblical Theology, Jason DeRouchie & othersHow to Understand & Apply the Old Testament, Jason DeRouchieDelighting in the Old Testament, Jason DeRouchieJesus in the Old Testament, Ian DuguidWalking with Jesus Through His Word, Dennis JohnsonJourneys With Jesus, Dennis JohnsonThe Promised One: Seeing Jesus in Genesis, Nancy GuthrieThe Lamb of God: Seeing Jesus in Exodus & Leviticus, Nancy GuthrieJoseph: A Story of Love, Hate, Slavery, Power & Forgiveness, John LennoxArticlesFinding Christ in All of Scripture, Shane RosenthalWhat is the Most Important Thing Taught in the Bible?, Shane RosenthalA New Way of Reading Scripture, Shane RosenthalJustin Martyr on the Importance of Fulfilled Prophecy, Shane RosenthalThe Bethlehem Prophecy: An Exploration of Micah 5:2, Shane RosenthalSprinkled Nations & Speechless Kings, Shane RosenthalWhy Should We Believe The Bible? (PDF), Shane RosenthalAudioComing to Grips with the God of the OT (1), WHI #1584 with Tom EggerComing to Grips with the God of the OT (2), WHI #1585 with Tom EggerIn The Beginning Was the Word, HS #75 with John RonningThe Messiah's Redemptive Mission, HS #72The Angel of Yahweh, with Matt Foreman & Doug Van DornDecoding The Prophecies of Daniel, HS #68Babylon, Humble Skeptic #66Jacob's Ladder, HS #63 with Richard Bauckham & Michael HortonThe Earliest Gospel, HS #46 with Mike BrownHow to Read & Interpret the Bible, HS #37 with Mike BrownThe Big Picture, HS #26 with J. Daniel HaysWhat Did the Earliest Christians Believe?, HS # 25 with Dennis JohnsonVideoShane Rosenthal on Frank Turek's Cross Examined PodcastShane Rosenthal on The Alisa Childers PodcastWrite a Positive ReviewIf you're a fan of this podcast, consider writing a brief note to let others know what you like about it (preferably via the Apple Podcast app since their reviews are visible in many other podcast portals). Positive reviews help boost our algorithms! Get full access to The Humble Skeptic at www.humbleskeptic.com/subscribe

The Humble Skeptic
In the Beginning Was the Word...

The Humble Skeptic

Play Episode Listen Later May 15, 2025 45:06


“In the beginning was the Word, and the Word was with God, and the Word was God.” What exactly do these words mean? Some argue that John is hinting at concepts related to Greek philosophy, but is this really the case? What are the Jewish Targums and how do these ancient texts helps us to better understand the meaning of John's prologue? On this episode, Shane talks with John Ronning, author of The Jewish Targums and John's Logos Theology.Click here for detailed notes related to this episode (including quotes from Philo of Alexandria, and the Aramaic Targums.SHOW NOTESBooksThe Jewish Targums & John's Logos Theology, John RonningTargum Isaiah, Jonathan ben UzielThe Messiah of the Targums, Michael B. ShepherdThe Jewish Gospels, Daniel BoyarinThe Angel of the Lord, Foreman & Van DornJourneys with Jesus, Dennis JohnsonThe Son of Man in Early Jewish Literature, Richard BauckhamA Handbook on the Jewish Roots of the Christian Faith, Craig EvansA Handbook on the Jewish Roots of the Gospels, Craig EvansThe Jewish Annotated New Testament, Daniel Boyarin & othersThe Works of Philo, Philo of AlexandriaArticlesThe “I Am” Sayings in John, John RonningThe Targum of Isaiah and the Johannine Literature, John RonningWhen Yahweh Became Flesh And Dwelt Among Us, John RonningHigh & Lifted Up: The Son of Man in John's Gospel, John RonningFinding Christ in All of Scripture, Shane RosenthalThe Bethlehem Prophecy: An Exploration of Micah 5:2, Shane RosenthalAuthenticating the Fourth Gospel, Shane RosenthalThe Identity of the Beloved Disciple, Shane RosenthalA New Argument for John's Identity, Shane RosenthalNotes for Episode #75, Shane RosenthalAudioJewish Views of the Messiah, Humble Skeptic #38 with Daniel BoyarinThe Angel of Yahweh, Humble Skeptic #70 with Foreman & Van DornWere Jews Expecting a Divine Messiah?, WHI #1243 with Craig EvansWere Jews Expecting a Suffering Messiah? Humble Skeptic #47Jacob's Ladder, Humble Skeptic #63 with Richard Bauckham and othersBabylon, Humble Skeptic Episode #66 Decoding the Prophecies of Daniel, Humble Skeptic #68 The Messiah's Redemptive Mission, Humble Skeptic #72Signs of the Messiah, Humble Skeptic # 74 with Andreas KöstenbergerWhich John Wrote John? Humble Skeptic #50SPECIAL OFFER — If you upgrade to a PAID subscription or make a GIFT of any size, we'll send you a pre-release PDF download of Shane's forthcoming book, Luke's Key Witness. When you subscribe, you'll get instant access to the book here (it's currently behind a paywall). If you choose the donation option, you'll receive the PDF via email. Thanks for your support! Get full access to The Humble Skeptic at www.humbleskeptic.com/subscribe

The Peter Attia Drive
#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.

The Peter Attia Drive

Play Episode Listen Later May 12, 2025 133:28


View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Rachel Rubin is a board-certified urologist and one of the nation's foremost experts in sexual health. In this episode, she shares her deep expertise on the often-overlooked topic of women's sexual health, exploring why this area remains so neglected in traditional medicine and highlighting the critical differences in how men and women experience hormonal decline with age. Rachel explains the physiology of the menstrual cycle, the complex hormonal shifts of perimenopause, and the wide-reaching health risks associated with menopause, including osteoporosis, cardiovascular disease, dementia, and recurrent urinary tract infections. She also breaks down the controversy surrounding hormone replacement therapy (HRT), particularly the damaging legacy of the Women's Health Initiative study, and provides guidance on the safe and personalized use of estrogen, progesterone, and testosterone in women. With particular emphasis on local vaginal hormone therapy—a safe, effective, and underused treatment—Rachel offers insights that have the potential to transform quality of life for countless women. We discuss: Rachel's training in urology and passion for sexual medicine and women's health [3:00]; Hormonal changes during ovulation, perimenopause, and menopause: why they occur and how they impact women's health and quality of life [5:30]; Why women have such varied responses to the sharp drop in progesterone during the luteal phase and after menopause, and the differing responses to progesterone supplementation [14:45]; The physical and cognitive health risks for postmenopausal women who are not on hormone therapy [17:45]; The history of hormone replacement therapy (HRT), and how misinterpretation of the Women's Health Initiative study led to abandonment of HRT [20:15]; The medical system's failure to train doctors in hormone therapy after the WHI study and its lasting impact on menopause care [29:30]; The underappreciated role of testosterone in women's sexual health, and the systemic and regulatory barriers preventing its broader use in female healthcare [35:00]; The bias against HRT—how institutional resistance is preventing meaningful progress in women's health [46:30]; How the medical system's neglect of menopause care has opened the door for unregulated and potentially harmful hormone clinics to take advantage of underserved women [53:30]; The HRT playbook for women part 1: progesterone [57:15]; The HRT playbook for women part 2: estradiol [1:05:00]; Oral formulated estrogen for systemic administration: risks and benefits [1:13:15]; Topical and vaginal estrogen delivery options: benefits and limitations, and how to personalize treatment for each patient [1:17:15]; How to navigate hormone lab testing without getting misled [1:24:15]; The wide-ranging symptoms of menopause—joint pain, brain fog, mood issues, and more [1:31:45]; The evolution of medical terminology and the underrecognized importance of local estrogen therapy for urinary and vaginal health in menopausal women [1:37:45]; The benefits of vaginal estrogen (or DHEA) for preventing UTIs, improving sexual health, and more [1:41:00]; The use of DHEA and testosterone in treating hormone-sensitive genital tissues, and an explanation of what often causes women pain [1:50:15]; Is it too late to start HRT after menopause? [1:56:15]; Should women stop hormone therapy after 10 years? [1:58:15]; How to manage hormone therapy in women with BRCA mutations, DCIS (ductal carcinoma in situ), or a history of breast cancer [2:00:00]; How women can identify good menopause care providers and avoid harmful hormone therapy practices, and why menopause medicine is critical for both women and men [2:06:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Trippin Around the World w/ Ari Shaffir

Play Episode Listen Later Apr 1, 2025 122:05


What's up guys thank you for being here we're so excited for this episode! Ari Shaffir is one of the most notoriously funny comics on earth, and he came through with some insane trip stories as we hoped he would!! Make sure to check out his new special "America's Sweetheart" out now on Netflix. UNRESTRICTED : ⁠https://www.dopeasusualpodcast.com/unrestricted⁠ DISCOUNT CODES : ⁠https://www.dopeasusualpodcast.com/sponsors⁠ NEW MERCH : ⁠https://www.dopeasusualpodcast.com/shop⁠ SPOTIFY : ⁠⁠https://yolalinks.com/spotify⁠ INSTAGRAM : ⁠https://instagram.com/dope_as_usual_podcast⁠ TWITTER : ⁠https://twitter.com/dope_as_usual ⁠ THOMAS : ⁠https://instagram.com/dope.as.yola ⁠ MARTY : ⁠https://instagram.com/marty_made_it ⁠ ARI : ⁠https://www.instagram.com/arishaffir⁠ APPLE PODCASTS : ⁠https://yolalinks.com/apple⁠ PHOTOS : ⁠https://drive.google.com/drive/folders/18McJgS0cS2Vtz1dVn-VpLujrVO2OjZ27⁠ Chapters: 00:00 Intro 00:41 Stash & Dash 02:36 Getting Dosed By Joey Diaz 04:32 Rogan & Ed*bles 06:11 D*bs 08:16 Salv*a 09:28 A*id 10:24 Don't Be Dumb 10:41 Shr*oms 11:33 Whi*pets/Gone Wrong 14:08 Shr*oms Before Performing 16:04 Ecst*sy W/ M*th 17:35 Parachute Dr*g 18:18 Story: Dr*gs At Fest In England 22:13 Thomas Trip 23:28 Story: Ac*d For The 1st Time W/ Joey Diaz 27:50 Watching Rogan Blow Up 30:18 Friends Becoming Famous 31:05 Redban's Influence On Podcasting 32:32 Dealing W/ Censorship 34:21 Ads 36:00 "If They Only Knew You..." 38:15 Legal W*ed 40:22 How Netflix Special Happened 42:41 Yola's Jewish/Step Dad Story 43:38 Arab Or Armenian? 44:32 Mexicans 45:35 Migrant Caravan 46:17 Movie Magic 49:17 Story: P*rn Shoot 51:00 Story: Freaky Berlin Nightclub 52:36 Voter Fraud 56:25 “The Amazing R*cist”: Was It Real? 1:00:21 Cops Got Fired For Watching 1:02:00 Freaking Out In Airports 1:05:40 Farewell Tour? 1:07:16 Story: Backpacking Europe 1:08:05 Hostels 1:11:07 Death Threats 1:12:20 Story: Brawl At Staples Center 1:14:33 Story: Tripping At Ufcs 1:19:18 Shro*mfest 1:21:51 Golden Era In Comedy 1:23:20 Jre Brought Back Comedy Store 1:27:01 "I'm Scared Every Time" 1:27:15 Tips To Get Out Of Bad Trip 1:30:01 "I'm A Contrarian" 1:30:58 Story: Doing Ayah*asca In The Jungle 1:55:53 Story: Ac*d Tripping Inside The Pyramids 2:00:43 Outro Thank you for watching! The Ari Shaffir Episode | DOPE AS USUAL Podcast #dopeasusual #podcast #arishaffir Learn more about your ad choices. Visit megaphone.fm/adchoices