Podcasts about Georgios

A lo-fi version of the show this week, as Dori had a bumper bashing that did not lead to Adventures in Babysitting-style shenanigans.Dolph Lundgren dons a wig and teases Paulo, while Dori is intrigued by the most banned movie of all time — which just happens to be from the '80s and also happens to sound like a Berlin techno club.We take the time to remember Val Kilmer's most '80s — and '80s-adjacent — movies. Plus, we recap all the lovely acts of charity performed by George Michael, which raised the question: £25,000 or a cappuccino with Georgios?We also find out that the crowd at a Journey concert just goes on and on and on… while Paul Young goes nowhere without holding onto the railings.Jump to: - Dolph Lundgren is a tease (00:02:40) - Silent Album Protest (00:05:00) - Necromantic (00:10:30) - Val Kilmer Tribute (00:15:25) - George Michael's Generosity (00:30:10) - Journey Concert Fire (00:34:36) - Paul Young's Injury (00:36:14)https://movieweb.com/masters-of-universe-dolph-lundgren-cameo-tease/https://english.elpais.com/culture/2025-02-25/thousands-of-british-artists-back-silent-album-against-ai-is-this-what-we-want.html?outputType=amphttps://www.imdb.com/video/vi1319420697/?playlistId=tt0089886&ref_=ext_shr_lnkhttps://www.dailymail.co.uk/news/article-14200643/George-Michaels-kindness-remembered-Christmas-star-funded-IVF-hopefuls-treatment-paid-strangers-25-000-debt-changed-ladys-car-tyre-rain.htmlhttps://www.express.co.uk/celebrity-news/2027884/beloved-80s-band-concert-abruptly-haltedhttps://www.express.co.uk/celebrity-news/2028556/paul-young-age-hospital-fall

Explore Atlantis like never before with Jack Kelley, director of The Atlantis Puzzle. Discover the Richat Structure, mistranslations in Plato's texts, and groundbreaking evidence about this legendary lost civilization.In this episode, I sit down with Jack Kelley, the director of the captivating documentary "The Atlantis Puzzle". This groundbreaking film explores one of history's greatest mysteries: the lost civilization of Atlantis. Could everything we've believed about Atlantis be wrong? Jack Kelley challenges long-held myths and offers fresh perspectives based on the groundbreaking research of George Sarantitis.We dive into fascinating topics, including the potential real location of Atlantis at the Richat Structure (Eye of the Sahara), how mistranslations in Plato's writings have misled researchers for centuries, and what modern climate science and archaeology reveal about ancient civilizations.Don't miss this thought-provoking discussion that redefines the story of Atlantis and its legacy. Check out "The Atlantis Puzzle", now available on Amazon, Google Play, and YouTube Movies.Check out my interview with Georgios Sarantitis here: https://youtu.be/vfO1nQulCIs

Jamie speaks with Georgios Petropoulos. He's served with the United Nations Office for the Coordination of Humanitarian Affairs since 2012. He completed his most recent assignment in January as Head of Suboffice in Gaza. Georgios describes the immediate aftermath of the ceasefire. He explains that there was a sigh of relief as people went back to see what, if anything, was left of their homes. Jamie and Georgios talk about the obstacles in providing basic aid to the area. The challenges include lack of mobility and security. Jamie asks him what impact a ban on UNRWA will have for humanitarian assistance, and Jamie asks him what he believes the future could look like for Gaza.

Marco ist wieder da. Eintracht Frankfurt ist wieder da. Und die kriselnde Borussia ist auch wieder da. Beste Voraussetzungen also für eine klassisch-angespannte, mit Frotzeleien gespickte Folge Rasenballspott. Nachdem VfB-Steffen dankenswerterweise für Marco eingesprungen ist, ist der neutrale Fußballkenner nun wieder zurück, um Stephan kiloweise Salz in die offenen Wunden zu streuen.

Bright on Buddhism - Episode 105 - Who is Amitabha? What are some stories about him? How ought we understand him?Resources: Karashima, Seishi (2009), JSTOR 24049429 On Amitābha, Amitāyu(s), Sukhāvatī and the Amitābhavyūha], Bulletin of the Asia Institute, New Series, 23, 121–130Charles Muller, "Buddha of Immeasurable Life 無量壽佛" Digital Dictionary of Buddhism,http://www.buddhism-dict.net/cgi-bin/xpr-ddb.pl?71.xml+id(%27b7121-91cf-58fd-4f5b%27)Tanaka, Kenneth K. 1990. The Dawn of Chinese Pure Land Buddhist Doctrine: Ching-ying Hui-yüanʼs Commentary on the Visualization Sutra, p. 12. Albany: State University of New York Press.The Three Pure Land Sutras (PDF), translated by Inagaki, Hisao, Berkeley: Numata Center for Buddhist Translation and Research, 2003, ISBN 1-886439-18-4,Georgios T. Halkias, Luminous Bliss: A Religious History of Pure Land Literature in Tibet Pure LandJones, Charles B. (2019). Chinese Pure Land Buddhism, Understanding a Tradition of Practice. Honolulu: University of Hawai‘i Press.Jones, Charles B. (2021). Pure Land: History, Tradition, and Practice. Shambhala Publications. ISBN 978-1-61180-890-2.Amstutz, Galen (1998). The Politics of Pure Land Buddhism in India, Numen 45 (1), 69–96 JSTOR 3270334 (subscription required)Inagaki, Hisao, trans. (2003), The Three Pure Land Sutras (PDF), Berkeley: Numata Center for Buddhist Translation and Research, ISBN 1-886439-18-4, archived from the original (PDF) on May 12, 2014.Müller, F. Max (trans) Buddhist Mahâyâna texts Vol. 2: The larger Sukhâvatî-vyûha, the smaller Sukhâvatî-vyûha, the Vagrakkedikâ, the larger Pragñâ-pâramitâ-hridaya-sûtra, the smaller Pragñâ-pâramitâ-hridaya-sûtra. The Amitâyur dhyâna-sûtra, translated by J. Takakusu. Oxford, Clarendon Press 1894. Pure Land Sutras.Shi Wuling: In one Lifetime: Pure Land Buddhism, Amitabha Publications, Chicago 2006. ISBN 978-1-59975-357-7.Halkias, Georgios and Richard Payne. Pure Lands in Asian Texts and Contexts: An Anthology. University of Hawaii Press, 2019.Halkias, Georgios. Luminous Bliss: A Religious History of Pure Land Literature in Tibet, with an annotated English translation and critical edition of the Orgyan-gling Gold manuscript of the short Sukhāvatīvyūha-sūtra. Hawaii: University of Hawai‘i Press 2013. [1]Johnson, Peter, trans. (2020). The Land of Pure Bliss, On the Nature of Faith & Practice in Greater Vehicle (Mahāyāna) Buddhism, Including a Full Translation of Shàndǎo's Commentary in Four Parts Explaining The Scripture About Meditation on the Buddha 'Of Infinite Life' (Amitāyur Buddha Dhyāna Sūtra, 觀無量壽佛經), ISBN 978-1-7923-4208-0.Kenneth Tanaka (1989). Bibliography of English-language Works on Pure land Buddhism: Primarily 1983–1989, Pacific World Journal, New Series, Number 5, 85–99.Do you have a question about Buddhism that you'd like us to discuss? Let us know by tweeting to us @BrightBuddhism, emailing us at Bright.On.Buddhism@gmail.com, or joining us on our discord server, Hidden Sangha ⁠⁠⁠⁠⁠⁠⁠https://discord.gg/tEwcVpu⁠⁠⁠⁠⁠⁠⁠!Credits:Nick Bright: Script, Cover Art, Music, Voice of Hearer, Co-HostProven Paradox: Editing, mixing and mastering, social media, Voice of Hermit, Co-Host

In this episode, Adam talks to Dr Georgios Efthimiou from the University of Hull.  Georgios has created a nationwide ‘spooky' short story competition called Coccus Pocus. This project links outreach and Halloween with microbiology.  This creative competition has had a clear impact on 12 – 18-year-olds who find the competition a good way to discover an interest in microbiology and have had a lot of fun writing the stories.  Join Adam as he learns more about this Microbiology Society-funded project (and you may hear from a few society staff members reading some of this year's winners along the way).

La primera se refiere a una escuela de especulación intelectual surgida en el último cuarto del siglo XX en el Reino Unido, y propone obras disonantes y atonales, densas y abstractas. La segunda recupera, a partir de la llegada del minimalismo, elementos tonales olvidados._____Has escuchadoDistentio (1992) / Walter Zimmermann. Ensemble Recherche. Mode (2002)Et lux (2009) / Wolfgang Rihm. Huelgas Ensemble, Paul Van Nevel, director; Minguet Quartett, cuarteto de cuerda. ECM (2015)Funérailles I (1969-1977) / Brian Ferneyhough. Arditti Quartet; Ensemble Recherche; Virginie Tarrête, arpa. Stradivarius (2005)Time and Motion Study I (1971-77) / Brian Ferneyhough. Carl Rosman, clarinete bajo. Etcétera (1998)_____Selección bibliográficaÁLVAREZ FERNÁNDEZ, Miguel, “Disonancia y emancipación: comodidad en/de algunas estéticas musicales del siglo XX”. Espacio Sonoro, n.º 4: [PDF]BALIK, Jessica, “Romantic Subjectivity and West German Politics in Wolfgang Rihm's Jakob Lenz”. Perspectives of New Music, vol. 47, n.º 2 (2009), pp. 228-248*BONS, Joël, “Entretien avec Brian Ferneyhough”. En: Musique en création. Contrechamps Editions, 1997*COURTOT, Francis, Brian Ferneyhough: figures et dialogues. L'Harmattan, 2009*DELIÈGE, Célestin, Cinquante ans de modernité musicale: de Darmstadt à l'IRCAM. Contribution historiographique à une musicologie critique. Mardaga, 2003*DUNCAN, Stuart Paul, “Re-Complexifying the Function(s) of Notation in the Music of Brian Ferneyhough and the ‘New Complexity'”. Perspectives of New Music, vol. 48, n.º 1 (2010), pp. 136-172*FERNÁNDEZ, Isaac D. G., “Los retornos en la música contemporánea”. Sinfonía Virtual: Revista de Música Clásica y Reflexión Musical, n.º 8 (2008), consultada el 21 de junio de 2023: [Web]FERNEYHOUGH, Bryan, “Form-Figure-Style: An Intermediate Assessment”. Perspectives of New Music, vol. 31, n.º 1 (1993), pp. 32-40*FISK, Josiah, “The New Simplicity: The Music of Górecki, Tavener and Pärt”. The Hudson Review, vol. 47, n.º 3 (1994), pp. 394-412*FOX, Christopher, “Walter Zimmermann's Vom Nutzen Des Lassens”. Tempo, n.º 154 (1985), pp. 49-50*HARVEY, Jonathan, “Brian Ferneyhough”. The Musical Times, vol. 120, n.º 1639 (1979), pp. 723-728*HERNÁNDEZ CRISTANCHO, Diego A., Una composición elaborada a partir del concepto de sintaxis musical de la nueva complejidad. Tesis de grado, Universidad Distrital Francisco José de Caldas, 2015, consultada el 21 de junio de 2023: [Web]HOWARD, Luke B., “Motherhood, ‘Billboard,' and the Holocaust: Perceptions and Receptions of Górecki's Symphony No. 3”. The Musical Quarterly, vol. 82, n.º 1 (1998), pp. 131-159*THEOCHAROUS, Georgios, “Not Too Violent: The Fall of Notation in Michael Finnissy's Autumnall for Solo Piano”. Perspectives of New Music, vol. 52, n.º 1 (2014), pp. 4-27*TOOP, Richard, “On Complexity”. Perspectives of New Music, vol. 31, n.º 1 (1993), pp. 42-57*TRUAX, Barry, “The Inner and Outer Complexity of Music”. Perspectives of New Music, vol. 32, n.º 1 (1994), pp. 176-193*ULMAN, Erik, “Some Thoughts on the New Complexity”. Perspectives of New Music, vol. 32, n.º 1 (1994), pp. 202-206*WARNABY, John, “Wolfgang Rihm's Recent Music”. Tempo, n.º 213 (2000), pp. 12-19*WILLIAMS, Alastair, “Swaying with Schumann: Subjectivity and Tradition in Wolfgang Rihm's ‘Fremde Szenen' I-III and Related Scores”. Music & Letters, vol. 87, n.º 3 (2006), pp. 379-397* *Documento disponible para su consulta en la Sala de Nuevas Músicas de la Biblioteca y Centro de Apoyo a la Investigación de la Fundación Juan March

As XRP's native stablecoin $RLUSD continues to expand its footprint, interoperability will play a key role. Axelar is the Web3 interoperability platform. An open stack to connect all blockchains. A single click to use and build everywhere.Guests:Jasmine Cooper - Head of Product at RippleXXRP Ledger Website ➜ https://xrpl.org/Georgios Vlanchos - Co-founder of Axelar Protocol & Director at Axelar FoundationAxelar Website ➜ https://bit.ly/aXelaRP~This episode is sponsored by Uphold~Uphold Get $20 in Bitcoin - Signup & Verify and trade at least $100 of any crypto within your first 30 days ➜ https://bit.ly/pbnuphold00:00 intro00:18 Sponsor: Uphold00:43 RLUSD vs PayPal USD01:19 Axelar02:24 XRP Recent Activity03:39 RLUSD Growth04:35 Expanding RLUSD & XRP08:43 RLUSD on More Exchanges09:36 One-Click Interoperability11:36 Axelar Utilitization Growing Fast13:39 Speed of Innovation & Dev Growth17:00 Solana & Flow Coming17:46 The Most Trusted Bridge20:43 Deutsche Bank & Enterprise22:36 XRP Coming to RWA Website23:16 Priorities For 202525:28 Axelar Roadmap26:38 AI Agents Going Cross-Chain27:47 outro#Crypto #XRP #xrpnews ~XRP & $RLUSD Going Cross-Chain!️‍

Georgios Vlachos, Co-Founder of Axelar protocol and director at Axelar Foundation. Georgios received his BSc and MS Eng. in computer science at MIT. After graduation, he became part of the Algorand founding team, where he worked on the design and development of the consensus protocol and other core components. While in high school, Georgios became the first Greek to win a gold Medal at the International Mathematical Olympiad.In this conversation, we discuss:- The financial crisis in Greece and current day economy in Argentina- The power of crypto in countries without Robust banking systems- Early days of Algorand- Why Cross-chain Bridges Fall Short - True interoperability demands collaboration across projects, not just patched-together solutions.- AI agents will be the biggest users of blockchains- Could there be a world where every human has their own blockchain?- RWAs and DePIN need interoperability- Connecting on-/off-chain systems- Deploying your token on many chains with a couple of clicks- Crypto needs more applications and less infrastructure- How AI will impact cryptoAxelar FoundationWebsite: www.axelar.networkX: @axelarTelegram: t.me/axelarcommunityGeorgios VlachosX: @yorgosv_LinkedIn: Georgios Vlachos ---------------------------------------------------------------------------------  This episode is brought to you by PrimeXBT.  PrimeXBT offers a robust trading system for both beginners and professional traders that demand highly reliable market data and performance. Traders of all experience levels can easily design and customize layouts and widgets to best fit their trading style. PrimeXBT is always offering innovative products and professional trading conditions to all customers.   PrimeXBT is running an exclusive promotion for listeners of the podcast. After making your first deposit, 50% of that first deposit will be credited to your account as a bonus that can be used as additional collateral to open positions.  Code: CRYPTONEWS50  This promotion is available for a month after activation. Click the link below:  PrimeXBT x CRYPTONEWS50

— IN THE TRANSITS: — October 22   (Tue) Mercury trine Saturn Rx: Make a Deal October 22   (Tue) Sun square Pluto: Intense Positioning October 22   (Tue) Sun ingress Scorpio: Scorpio Dive October 24   (Thu) Mars sextile Uranus Rx: What is Changing? (Central Time for all dates & times)  Follow along with these transits personally! Download your Natal Chart: https://intentionbeads.com/chart — OUR HOUSE: — Sandy & Alex have a very special guest, Georgios Karimalis- the owner of the Ikarian Farm Stay!

Der Pianist Lyssarides und der Bouzouki-Spieler Prokopiou haben sich einen Spaß daraus gemacht, Jazzstandards ins Griechische zu übersetzen. Das Album „Arcs and Rivers" ist ein musikalisches Experiment, das unbedingt eine Entdeckung wert ist, schwärmt unser Jazzkritiker Johannes Kaiser.

This is my conversation with Georgios Konstantopoulos, General Partner and CTO at Paradigm.Timestamps:(00:00:00) - intro(00:00:47) - iterating on rollups(00:07:52) - Reth architecture(00:25:44) - sponsor: Splits(00:26:27) - feedback loops with performance, stability, extensibility(00:36:14) - feedback loops with the team(00:49:17) - writing for thinking(00:54:47) - the big vision(01:10:49) - outroLinks:Georgios Konstantopoulos on X - https://x.com/gakonstGeorgios Konstantopoulos on LinkedIn - https://www.linkedin.com/in/gakonsParadigm on X - https://x.com/paradigmTailscale Blog: The New Internet - https://tailscale.com/blog/new-internetThank you to our sponsor for making this podcast possible:Splits - https://splits.orgInto the Bytecode:Sina Habibian on X -  https://twitter.com/sinahabSina Habibian on Farcaster - https://warpcast.com/sinahabInto the Bytecode - https://intothebytecode.comDisclaimer: this podcast is for informational purposes only. It is not financial advice nor a recommendation to buy or sell securities. The host and guests may hold positions in the projects discussed.

Manche Roads to Essen kommen von weit her. Peer und Georgios sprechen über die Neuheiten des singapurischen Verlags Origame, eine Neuheit von Hobby World, einem neuen Spiel von Saashi & Saashi, kleine japanische Kartenspiele von Allplay, die für den internationalen Markt erscheinen und spannende Lokalisierungen von Kosmos, Frechverlag und Strohmann Games.

Avsnitt 239 av Podcast Juventus Club Svezia med JCS-Gästen Georgios Katachiotis, som gör en tredje återkomst i podden efter att ha varit med i avsnitt 121, 154 och 159. Vi snackade ned helgens match mot Napoli samt PSV Eindhoven i Champions League-premiären, Thiago Mottas fotboll, Dusan Vlahovic:s måltorka, ligan kontra CL, Wojciech Szczesnys farväl, Leonardo Bonucci på läktaren två matcher i rad, Giorgio Chiellinis återkomst i klubben, Alessandro Del Pieros potentiella samt Antonio Contes återkomst till Allianz Stadium och hans eftermäle.   Stöd gärna podden du med, bli patron: https://www.patreon.com/podcastjuventusclubsvezia   Intro/Outro Podcast Juventus Club Svezia, skapad av: Roger Myrehag - Oboogie Music  

174: How and Why Ancient Greece is Still Relevant Today On today's episode. Archeologist Dr. Georgios Koukovasilis joins the podcast to share how ancient Greece is everywhere in the modern world. Dr. Georgios Koukovasilis  Georgios and Kiki  Today's Lexi:  Ancient – Αρχαίος – Archaíos In Today's Episode: During Kiki's summer visit to the Temple of Poseidon she had the great honor to meet and connect with a wonderful archologist.  Dr. Koukovasilis – PhD in Classical Art and Archeology – is a wealth of education, passion and knowledge regarding the ancient word and how it is everywhere we look and how we live in the modern world. Today meet Dr. Koukovasilis and discover how do we define archeology?  What drew Dr. Georgios to this field and how and why is Classical life relevant today.   Can we draw conclusions about humanity and well-being by looking back?   How can we move forward with progress and confidence? All this and more during episode 174. Resources: Georgios Koukovasilis | Center for Hellenic Studies in Greece (Harvard) Archaeology at Cambridge Georgios Koukovasilis on Instagram (@george_koukos__) Credits: Music: Spiro Dussias Vocals: Zabrina Hay Graphic Designer: Susan Jackson O'Leary  

There's always more to the story… This week, we start taking our deep dive into one of the biggest musicians of the 80s and 90s. Behind the millions of albums sold, worldwide, concerts, and unspeakable levels of fame, George Michael was a complicated person. How much do you really know about this superstar? Find out as we begin the ballad of the great George Michael this week on the Rock and Roll Heaven podcast! Audition for American Idol - Lynly.Ehrlich@americanidol.com Our social stuff: Patreon.com/rockandrollheaven Twitter: @rockandrolllt Instagram: Rockandrollheavenlt Facebook: Rock and Roll Heaven Pod Our website: https://rockandrollheavenl.wixsite.com/mysite Tick Tok: rockandrollheavenpod Email us! rockandrollheavenlt@gmail.com Check out the other awesome Pantheon Podcast at www.pantheonpodcasts.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Life in Plastics: It's Fantastic. In our first episode, we're really going to get under your skin – deep beneath its surface – past the SMAS and into the layers where skin ageing truly occurs. Our guide? The brilliant Georgios Orfaniotis. We're exploring the fascinating world of facelifts, covering the most common age for these procedures, the truth about the recovery process, the real scoop on how many A-listers have gone under the knife and the must-knows, myths, and misconceptions about non-surgical treatments and their impact on surgical outcomes. We take a deep dive into the Deep Plane Facelift – a revolutionary technique that George pioneers for restoring your unique facial structure to its youthful state, naturally and without the dreaded 'wind-blown' look. About our guest: Mr Georgios Orfaniotis is a fully-certified and internationally trained Plastic Surgeon and esteemed surgeon specialising in facial aesthetic surgery, with over 15 years of experience and over 8,000 operations under his belt. Georgios has extensively trained in Head and Neck reconstruction and over the years he has used these skills to develop an expertise in Facial Aesthetic Surgery. He is one of the few surgeons in the UK able to offer the most advanced facial rejuvenation techniques including; Extended Deep Plane Facelift, Deep Neck Lift, and Lip Lift. He sees patients and operates in prime central London in multiple locations. Hosted on Acast. See acast.com/privacy for more information.

**My apologies on my audio quality for this episode. Working off an old laptop for this particular recording. Early Christianity in Cyprus dates back to the first century AD, when the island was part of the Roman Empire. According to tradition, the apostles Paul, Barnabas, and John Mark traveled to Cyprus to spread the message of Christianity. The island is, of course, mentioned in the New Testament as the birthplace of Barnabas. In the early centuries of Christianity, Cyprus was an important center of Christian activity and played a key role in the spread of the religion in the Eastern Mediterranean (even producing Britain's first bishop -- St. Aristoboulos!). The Island of Saints was home to a number of significant early Christian figures, including St. Epiphanius, the bishop of Salamis, who wrote extensively about Christian theology and doctrine and Cyprus' bishops were active participants in the early Church Councils (such as The Council of Nicaea). While we know that violence erupted between pagans and Christians in cities such as Alexandria, what was the transition in Cyprus like? This month, I discuss The Last Pagans of Cyprus with Professor Georgios Deligiannakis!

Join us in this episode as we explore the profound impact of artificial intelligence on the marketing world with Georgios Grigoriadis, a seasoned expert in AI and the digital landscape. Georgios shares his insights on how AI is not just a tool but a transformative force that is reshaping marketing and altering our daily lives and functionalities.In this discussion, Georgios challenges us to rethink our perceptions of AI's capabilities, advocating for a more grounded and realistic understanding of what AI can truly achieve. He predicts that in the coming years, AI will become a central driver in marketing, revolutionizing how we engage with customers, analyze data, and execute campaigns.Tune in to discover how you can leverage AI's full potential within your marketing strategy and prepare for the sweeping changes that AI is set to bring to the industry. Whether you're a marketer, business owner, or just an AI enthusiast, this episode will provide you with a clearer view of the realistic impacts and exciting opportunities AI holds for the future of marketing.Don't forget to subscribe for more insights, and hit the like button if you find this discussion informative. Share your thoughts or questions in the comments below as we delve into the future of AI in marketing together!Subscribe to the Backstory on Marketing and AI for more updates on market trends and AI updates. Follow us on Facebook: https://www.facebook.com/profile.php?...Website: https://prorelevant.com/What's your backstory?

Laurent interviews Georgios Stassis, PPC'S CEO, during Eurelectric Power Summit 24.PPC, the Greek Utility, is a remarkable turnaround story: from a soviet-style dinosaur a few years ago, PPC has become a thriving forward-looking profitable modern Utility.With Georgios, we discuss the investment in renewables, the phase out of lignite, digitisation, the investment in new segments (Datacenters, E Mobility, Demand Response…) and share an overview of regional integration with interconnectors and the successful acquisition of Enel Romania.And, to crown it all, a Quiz: Eurelectric or AC/DC?

Münkel, Jana www.deutschlandfunkkultur.de, Studio 9 - Der Tag mit ...

A daily update on what's happening in the Rocket Pool community on Discord, Twitter, Reddit, and the DAO forum. Today's episode covers: Amazing spot ETH ETF news, 400th episode of Rocket Fuel, RPL ratio lows, and Justin Drake advises EigenLayer. 0:00 - Welcome 0:40 - OH FUCK OH FUCK - ETH ETF news https://x.com/EricBalchunas/status/1792636523050906102 https://x.com/JSeyff/status/1792637403682701422 https://www.binance.com/en/trade/ETH_USDT 6:49 - 400 episodes today https://discord.com/channels/405159462932971535/405163713063288832/1241138144053821544 Rocket Pool news 7:52 - RPL ratio hits new cycle lows https://discord.com/channels/405159462932971535/405163713063288832/1241856566592798750 https://discord.com/channels/405159462932971535/405503016234385409/1241946862572011520 9:46 - LST/LRT risks https://x.com/gauntlet_xyz/status/1791529656820388160 https://www.gauntlet.xyz/resources/liquid-restaking-token-lrt-market-risk-framework 
 11:57 - New Rocket Sweep update https://discord.com/channels/405159462932971535/405163713063288832/1241994170097209354 12:51 - Drama in Rocket Pool land https://discord.com/channels/405159462932971535/405163713063288832/1240935026129113088 https://discord.com/channels/405159462932971535/405163713063288832/1241972069747654736 https://discord.com/channels/405159462932971535/405163713063288832/1242106464290607114 16:10 - Breaking ETF news Staking news 17:17 - Justin Drake announces advisorship to EigenFoundationhttps://x.com/drakefjustin/status/1792143477163106787? https://x.com/orb_land/status/1792497075344531794 https://x.com/drakefjustin/status/1792482530928578947 https://x.com/eawosikaa/status/1792289090324382013 23:59 - Hasu and Vasily talk Lido research https://open.spotify.com/episode/364WNOub7Vm0vzbi7a9IxL?si=TknJX7bBSjKS8w1h7qCtlQ&context=spotify%3Ashow%3A0rGocvZ7oZR6vuy0UHKAON 25:57 - Puffer swapping out of Lido https://discord.com/channels/405159462932971535/405163713063288832/1242144990902354080 https://x.com/lidodominance 27:40 - Another Diva vote https://commonwealth.im/divastaking/discussion/17348-diva-transferrability Ethereum news 29:13 - More spot ETF breaking news 29:56 - OP stack fault proof proposal https://x.com/liamihorne/status/1791583020551397746?s=46 30:54 - ETH spot ETF insights https://x.com/nategeraci/status/1792330334169903568?s=46 https://x.com/qeycc/status/1792333564454846509?s=46 https://archive.ph/wNMI1 36:18 - Stablecoins taking over https://x.com/ryanwatkins_/status/1792269389141553469?s=46 38:17 - Will L2s split to become L1s? https://x.com/timjrobinson/status/1792019147670561230 39:13 - Georgios talks L2 scaling https://x.com/gakonst/status/1792088024769089655 40:18 - Where is crypto capital? https://x.com/ryanberckmans/status/1791877248536252632 41:59 - Into the Ether podcast relaunching https://x.com/econoar/status/1792538794237010156?s=46 In other news 43:15 - Political movements https://x.com/nicktimiraos/status/1792559780378103868?s=46 https://x.com/yugacohler/status/1792629770095632739?s=46

Georgios Grigoriadis, Founder and CEO of Baresquare, an AI-driven analytics platform, discusses his career journey from data scientist to founder and the development of Baresquare. He shares how the tool leverages AI-powered insights for marketing analytics, the challenges and opportunities in B2B marketing, and the potential of AI to empower individuals in marketing rather than replace them.   About Baresquare Baresquare redefines data analytics by transitioning from traditional dashboards to proactive, AI-powered insights delivered directly to the right person at the right time. Baresquare pioneers a new approach where manual dashboard analysis and human intervention are unnecessary for identifying crucial business events and their underlying causes. This frees marketers, strategists and analysts to focus on creative endeavors and expanding business opportunities while providing insight that no other data set can provide.   About Georgios Georgios Grigoriadis is a data advocate and the founder and CEO of Baresquare, a tech startup turning data analytics on its head by shifting from traditional dashboard-based analysis to proactive AI-powered insights, delivered directly to the right person at the right time. Fueled by the belief that data should empower, not overwhelm, Georgios built Baresquare to transform complex analytics into clear, useful answers for anyone to understand.   Time Stamps [00:46.1] – Georgios discusses what led him to build Baresquare. [06:11.9] – How can marketeers use Baresqaure? [06:48.8] – Georgios shares if he thinks the B2C industry is further ahead in using analytics. [19:47.1] – Georgios offers some marketing advice. [17:52.4] – Should young people embark on a marketing career? Georgios shares his opinions. [24:51.9] – Georgios and Mike talk about the future of AI and its impact on the industry. [31:48.9] – Georgios's contact details   Quotes “Baresquare today is turning data analytics on its head. And, we are not talking in terms of tables and numbers, but rather in terms of words and paragraphs." Georgios Grigoriadis, Founder and CEO at Baresqaure. “It's very frustrating when those insights, they don't find themselves driving action. But action, it's more a matter of communication. It's bringing people together and aligning their understanding.”  Georgios Grigoriadis, Founder and CEO at Baresqaure.   Follow Georgios: Georgios Grigoriadis on LinkedIn: https://www.linkedin.com/in/georgiosbaresquare/ Baresquare website: https://baresquare.com/  Baresquare on LinkedIn: https://www.linkedin.com/company/baresquare/   Follow Mike: Mike Maynard on LinkedIn: https://www.linkedin.com/in/mikemaynard/ Napier website: https://www.napierb2b.com/ Napier LinkedIn: https://www.linkedin.com/company/napier-partnership-limited/   If you enjoyed this episode, be sure to subscribe to our podcast for more discussions about the latest in Marketing B2B Tech and connect with us on social media to stay updated on upcoming episodes. We'd also appreciate it if you could leave us a review on your favourite podcast platform. Want more? Check out Napier's other podcast - The Marketing Automation Moment: https://podcasts.apple.com/ua/podcast/the-marketing-automation-moment-podcast/id1659211547

Summary This week, Anna and Tarun catch up with Georgios Konstantopoulos, CTO of Paradigm and long-standing friend of the ZK Pod! First they cover the work Georgios has been doing since he last appeared on the show, covering everything from updates on Foundry to the more recent work on Reth. They then dig into what makes it different, what inspires its design, where it is heading and the eventual end goals of the project. They also chat about the general client node landscape, from the ETH 2.0 research days to present day, before diving into discussing different clients from different teams, how this diversity can protect a chain and how each client can differ. Here's some additional links for this episode: Georgios' GitHub Introducing Reth by Paradigm Reth GitHub Episode 224: Foundry with Georgios Konstantopoulos Loom Network CryptoZombies Geth: Ethereum Full BSC Node Guide: How to Run BNB Smart Chain Nodes GitHub: flashbots:mev-geth Arbitrum Verkle Trees for Statelessness Check out the latest jobs in ZK at the ZK Podcast Jobs Board. The next ZK Hack IRL is happening May 17-19 in Kraków, apply to join now at zkkrakow.com. o1Labs is excited to announce the v1 release of o1js, THE fastest way to build zkApps and deploy to the Mina blockchain. After 2 years and 70,000 downloads, o1js v1 is the externally-audited, enterprise-grade Typescript zkDSL the community has been waiting for. Are you ready to build the next killer zkApp? Then visit o1js.org and get started today. Aleo is a new Layer-1 blockchain that achieves the programmability of Ethereum, the privacy of Zcash, and the scalability of a rollup. As Aleo is gearing up for their mainnet launch in Q1, this is an invitation to be part of a transformational ZK journey. Dive deeper and discover more about Aleo at http://aleo.org/ If you like what we do: Find all our links here! @ZeroKnowledge | Linktree Subscribe to our podcast newsletter Follow us on Twitter @zeroknowledgefm Join us on Telegram Catch us on YouTube

Georgios is a philosophy student and one who brings others along with him. Now, when I say he's a philosophy student, you think, ahh, he's taking a class.  No.  Georgios has a job. He lives in the real world with us outside academia. But he carves out time to study Aristotle and other writers and thinkers for fun and wisdom in the time he isn't working.  That's so amazing, this is my second time interviewing him. My first one looked at Socrates, Aristotle and what to do with this life.  This new one considers a new book from Georgios' working group of thinkers wrestling with a more obscure work of Aristotle's: The Categories.  It sounds like it'll be boring, but if you're into clumsily asked philosophical questions answered with passion by a Greek, well, here you are!    For further enjoyment:  Read Georgios' Substack on his and other group members' insights into the Aristotle readings. Here are collected summaries from Chapter 1 and Chapter 2.  Join Tom and Georgios in Aristotle's Organon Study Group Zoom Link every Tuesday 08:30pm CET/14:30pm EST.  Check out Georgios' Reddit post here for details on buying his book. Just 5EUR for the ebook to anyone who Paypals him at theduedissident@protonmail.com and mentions Brendan! Or you can buy it on Amazon, too.  Dive into Georgios' own subreddit, Philosophy of the Frontier. “Here, you will find philosophical content that I have written in the past two years,” he says. 

Be sure to visit our sponsor MasonMillchiro.com for all your chiropractic needs!1: We at least desired to counterattack tonight, but lacked execution. Our best open play opportunity came from Thiago after staying compact and winning the ball back and GOING.  2: In the first half there JNCO sized pockets of space that no one was running in to. That's on the players. The movement off the ball in the second half improved. Hard to counter when the runs don't happen.  3: Guzan isn't losing his spot. He was great.  4: Defensively we look much more organized and compact. There were a couple scary moments in the first half but you can see that the chemistry and communication is building.  5: Maybe a small thing, but Gonzo did not look all that thrilled at the end. Good. I think he was really annoyed at the goal we conceded, even if it was a quality hit from a man who's done it many times before. The mentality of not being satisfied is good. --- Welcome the newest pod from our new podcast network mates, Five Takes on the Five Stripes! Check it out and make sure to follow for more! --------- ▶ Find our podcast in audio form on your favorite podcatchers! --------- ▶ Support the channel while you shop for ATL UTD gear (at no extra cost to you!): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/atlantaunitedfantv⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --------- ▶ COP FROM OUR SHOP (grab some ATL UTD fan gear!): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://teechip.com/stores/tackl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --------- About Atlanta United Fan TV: We are created by fans for the fans of  Atlanta United and soccer. Join the community to get in on the conversation! Bringing you fan cams, podcasts, vlogs, mini-documentaries and much more! If you're a Five Stripe, we want to hear from you! Whatever you want to say about ATL UTD you can say it in the comments below. And to get in touch with us, connect with us: ▶ INSTAGRAM: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://goo.gl/9uOLVn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ▶ TWITTER: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://goo.gl/5uc709⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ▶ TWITCH: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.twitch.tv/atlutdfantv⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ▶ DISCORD: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/C4RXb2b⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ▶ FACEBOOK: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tinyurl.com/y3ga5mst⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ▶ SNAPCHAT: atlutdfantv17 ▶ TIK TOK: atlutdfantv --------- #ATLUTD #UniteAndConquer #MLS #WeAreTheA #AtlantaUnited --- Support this podcast: https://podcasters.spotify.com/pod/show/atlutdfantv/support

Be sure to visit our sponsor MasonMillchiro.com for all your chiropractic needs! 1: We at least desired to counterattack tonight, but lacked execution. That's on coaching. Our best open play opportunity came from Thiago after staying compact and winning the ball back and GOING.  2: In the first half there JNCO sized pockets of space that no one was running in to. That's on the players. The movement off the ball in the second half improved. Hard to counter when the runs don't happen.  3: Guzan isn't losing his spot. He was great.  4: Defensively we look much more organized and compact. There were a couple scary moments in the first half but you can see that the chemistry and communication is building.  5: Maybe a small thing, but Gonzo did not look all that thrilled at the end. Good. I think he was really annoyed at the goal we conceded, even if it was a quality hit from a man who's done it many times before. The mentality of not being satisfied is good.

This week we have TWO special guests on the show, Charlie and Rich Cummins from Georgios Coffee Roasters. I've been getting coffee from these guys for a while now and love what they do. Their passion is evedent and execution flawless! Come hang with us on this special COFFEE ONLY episode. Hosted on Acast. See acast.com/privacy for more information.

Dr Georgios Lyratzopoulos (University College London, London, UK) discusses his two papers from the International Cancer Benchmarking Partnership on the use of chemotherapy or radiotherapy in eight common cancers in Norway, the UK, Canada, and Australia.Continue this conversation on social!Follow us today at...https://twitter.com/thelancet & https://Twitter.com/TheLancetOncolhttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

O médico grego morreu faz hoje 62 anos.

The last episode of EUSPA's Mini series see the intervention of Dr Georgios Synnefakis, GOVSATCOM program manager at EUSPA. Dr Emma Gatti, Editor in Chief of SpaceWatch.Global, and Dr. Synnefakis discussed the importance of GOVSATCOM in providing secure satellite communications to governmental users in various scenarios, including crisis management and critical infrastructure support.They also discussed the role of EUSPA in implementing GOVSATCOM, its benefits for EU governments and European citizens, the security measures in place, and the connection between GOVSATCOM and the IRIS².Space Café Radio brings you talks, interviews, and reports from the team of SpaceWatchers while out on the road. Each episode has a specific topic, unique content, and a personal touch. Enjoy the show, and let us know your thoughts at radio@spacewatch.globalYou can find us on: Spotify and Apple Podcast!Please visit us at SpaceWatch.Global, subscribe to our newsletters. Follow us on LinkedIn and Twitter!

Join the Atlanta United FanTV Discord y'all! Great community.  https://discord.gg/SKx8UWYf   1: In the first 20 minutes we would, on occasion, win the ball back. We could have done with a little more emphasis on what comes directly after winning the ball back. I'd like to see us be more direct in those moments.  2: We got started when we stopped and started. We're not really a team that enjoys a stop start game but neither is Columbus. So we tried it out for size and it fit pretty well from the 18th minute on and we got the all important first goal.  *For me this essentially means we frustrated them. Something we failed to do last time and must do again on Sunday.    3: Giving up a goal at the worst possible time is nothing new to Atlanta. Responding immediately? That kinda isn't but we are here for it.  *Getting a yellow for the Spidey mask I stupid. Especially when MLS is tweeting out photos of it.  4: Missing a sitter is ugly. What followed was beautiful. Georgios grabbing his man and amping up the crowd into chants of SILVA!

Today's guest is Georgios Ouzounis, Head of AI Research at Atlas AI. Founded in 2018, Atlas AI brings together world class machine learning talent and deep domain expertise to develop software that allows customers to plan and monitor high stakes investments including infrastructure development initiatives and market expansion programs. It is their mission to monitor drivers of economic development across the emerging markets so that financial capital can advance societal well-being.  Georgios is a technologist, visionary and thought leader with over 24 years of experience in the front lines of scientific research, engineering and entrepreneurship in the hi-tech industry and across seven countries. Motivated by the quest for excellence in business practices and recognized for innovation, strategy and delivery, he has been driving corporate growth in the geospatial, intelligence, medical, healthcare, insurance, financial and consumer electronics sectors through leadership and technology.  In today's episode, Georgios will discuss: The mission and overview of Atlas AI, The role of various data layers in generating customer insights, Benefits that their products bring to organizations, Proudest moments in his career to date, What's in store for the future at Atlas AI, What makes Atlas AI a great place to work

Scholar Georgios Makris reflects on his experiences with researching and writing his article, “Jewelry and People in the Byzantine Cemetery of Parapotamos, Epiros,” which appears in Speculum 98:4.Jewelry reflecting the tastes, needs, and practices of past users across all social strata constitutes one of the most representative portable arts in the Middle Ages. Jewelry's typical lack of iconography or original context has often prevented scholars of Byzantine art from engaging with the medium's socio-historical value. By bringing together artworks from museum collections and objects found in the cemetery of Parapotamos, in northwestern Greece, this study disentangles medieval jewelry from an inquiry into provenance or the development of fashion and instead situates specific jewels in a discussion about meaning on a social level, in terms of ownership and human behavior in Byzantium and beyond.This episode is an installment in a special partnership with Speculum: A Journal of Medieval Studies. Each episode is designed to bring you behind the scenes of an article published in an upcoming Speculum issue. This episode is hosted by Katherine L. Jansen and Reed O'Mara.For more about Georgios, Byzantine jewelry, and this conversation, check out our Show Notes: https://tinyurl.com/mmapodcast.

1: Getting 3 points on any occasion is always a good thing. Even more so on the road against quality opposition. That being said, I think we were a little fortunate in how poor and how unlucky Seattle was. If we are going to make a run in these last games of the season, we have got to be more clinical in the final third. This game could have and should have been put away much sooner. Home or away, we need to be more ruthless.    2: Mosquera is an unrefined speed monster. You can see the energy and ability he has, but often times he's a little too anxious in his actions. He's an interesting player. Right now he has the ability to be impactful but I think there's more there than just being a little dangerous. If he stays with the club, he'd be one to watch next season in terms of his development.    3: Muyumba was vey good. Notably he won 7/10 of his duels. I think once he develops more chemistry with the team we will see more attacking sequences and outright chances come off off those duels won. It really is a sneaky important stat.    4: Georgios was a monster tonight. His head is gonna need an ice bath. Both goals came off from very strong headers, he won the ball via 4 tackles and I lost count of the number of big defensive headers he had. I think it's fair to say that we've never had a #9 like him. That's no disrespect to Josef who will always be a king and a legend here. But Georgios puts in more on both sides of the ball. I love it but I also find myself always waiting for the next injury to come for him. He works himself into the ground and has payed the price for it in his brief time here. It's why a quality backup 9 years I'll continue to be an important role for this club.    5: If we can follow this performance up with a strong win against Nashville at home where we dominate the game and take our chances better and earlier, than I think I'll be able to look back on tonight as a measured, controlled and maybe a little pragmatic performance. But if we don't, I am gonna feel that a poor Seattle performance and some good fortune played a bigger role in the win tonight. 

Allyzibeth 'Ally' LaMont was a young woman who worked at Local No. 9 Deli in Johnstown, NY. She bravely reported labor law violations at the deli, leading to retaliation from the deli owner, Georgios Kakavelos. James Duffy, an associate of Georgios, was recruited to Ally as a result of her whistleblowing. They brutally killed her and attempted to conceal the crime by burying her body in a shallow grave. Both Georgios Kakavelos and James Duffy were eventually arrested and brought to trial. Georgios received a life sentence without parole for first-degree murder, among other charges. James Duffy pled guilty to second-degree murder and was sentenced to 18 years to life in prison. --- Send in a voice message: https://podcasters.spotify.com/pod/show/shaychapman/message

1: The prevailing take from most is that our recent defensive success was been strictly down to having 3 CB's. I contest that that individual performances were of more consequence than the systems itself. New England's first two goals come from a mistake from Brooks (who honestly just got a little unlucky) and Sosa. Our last two matches were largely devoid of those mistakes. It's not just the formation.    2: Berry is such a known non threat that we actively avoid targeting him for anything. My lord Brooks beat him for the ball from Thiago in the first half and he started his run from midfield and still managed to have a go. It just can't be understated how ineffective we are in the attack with out an effective #9 and how much Berry is not that. Maybe we should start Chol as the 9 when Georgios can't go. I'd rather not because I think he's more effective coming off the bench but…F it.    3: Game state is everything. Doesn't matter if we lose by 1 goal or a bajillion. Once we're down were chasing, and more open and usually making more mistakes because we're in our own heads and just taking more risks. To our credit, after the 2nd goal we didn't let it get away from us and we gave ourselves enough chances to get back in.    4: Even if we make miles a DP I'm not sure he sticks around. He wants to go to Europe and I'm not sure another $1 million changes his mind. It's a lot of money but it's not set up for life kinda money and he isn't gonna earn much more than the only other DP CB in the league.    5: We are missing a #9 and we came up against one of, if not the best, keeper in the league. Pineda rightly made personnel and tactical changes in the 2nd half and to his credit, we played much better. Yes New England let off some, but still it was just a much better performance. Not for nothing but when was the last time New England was really good? Oh right, when they had another elite goal keeper in Matt Turner. It says a lot about your team when the key reason why your'e in a good position is because of your goal keeper. 

1: Well that was a very organized, one might even say, authentic performance. For me this is our best showing this season. When you take into account, the clean sheet, the quality of the opponent and losing Georgios, this was pretty damn complete. So why now and not against NYRB? I don't really know. Yes home field plays a role, but we largely played how we like to play, albeit with some different players, but overall I thought we just executed better.    2: Happy to see us play with more aggression and assertiveness against a team who plays with both. The boys got stuck into more challenges and weren't afraid to throw in a few shoulders and just use their physical strength more than we did against energy drink FC.    3: Caleb Wiley with the ball at his feet is an absolute joy to watch. He plays with so much energy and intent. When the ball comes to him he picks his head up and immediately works out the shortest path to goal. Having him charging at goal is a serious enough threat itself, let alone the freedom and space it gives to other attacking options. Oh and he had 7 ball recoveries and an interception.    4: Thiago is a cheat code. And like any cheat code, the same code does not work for every game. But my lord when it does, you're a given a game changing advantage.    5: Georgios, unfortunately, has a history with injuries and he's carried that history with him here. For me, we should be looking at yet another proper 9 backup in this window. Berry has shown us his ceiling and it's lower than Bilbo Baggins house. Tyler Wolff could serve in that role, but that's a lot of weight to put on his shoulders and he's been doing so well in his progression as is. I don't know if we want to change that up right now. If we have the ability to move Berry on, we should. 

Let's look at a few trends going on in workforce tech right now: inflation, layoffs, lack of VC funding, tightening budgets, and technological disruption. All combined to create uncertainty in multiple dimensions and end up laying the table for what should be a feeding frenzy for M&A. That's why we invited Georgios Markakis, managing partner at Venero Capital Advisors, to the show. In addition to the acquisition and fundraising landscape, we look back at what things were like during the pandemic, what's going on with IPOs, and what makes a good founder when dissecting M&A opportunities. It's a must-listen for vendors and the founders who run them.

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis, fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Georgios Frangulis é fundador e CEO da Oakberry, rede de lojas de açaí que está em 40 países e possui mais de 600 unidades no mundo!https://www.instagram.com/georgiosfrangulis/〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️〰️SOBRE O EXCEPCIONAIS

Summer is here, and for many brands, it brings a peak consumer buying season. Families are having parties, people are traveling, and there's a huge uptick in demand. As brands, are you taking advantage of this key time? How are you merchandising your products differently? Should you run promotions?I've invited on Georgios, VP of sales specializing in Emerging Brands with Trax to answer these questions.Startup to Scale is a podcast by Foodbevy, an online community to connect emerging food, beverage, and CPG founders to great resources and partners to grow their business. Visit us at Foodbevy.com to learn about becoming a member or an industry partner today.

1: Sucks to give up a goal. Sucks even more to give up a goal to an unmarked man on a set piece when you're largely in control of the match. They really did not have much in terms of chances from open play in the first 45 and you never got the feeling that it was coming so to concede like that really hurts because it affords the opponent the opportunity to sit back and protect that cheap lead.    2: We're missing Georgios. Chol is an interesting player but he's not an out and out striker and that has largely been this teams problem in recent years in terms of not scoring. He didn't make the same runs GG does to create not only opportunities for himself, but for space for others.    3: That was one of the coldest penalties I've seen. I thought for sure Thiago would try to go top shelf. But he played it cool in a high pressure moment, kept it on the ground and just rolled it in. Kid's got it all. His ability to dribble out of trouble and hit 50+ yard diagonals on a dime is just other worldly.    4: Luiz may have shown us about as much as he's capable of showing us. Barring some major turnaround and a real run of CONSISTENT form I just don't see how he remains on this team. Much less as a DP. He's skilled and brilliant in moments, but we need more than moments out of our DP's. His lack of productivity is killing us. It's just how this league works.    5: Well, I'd ask for a refund ala Tottenham, but the club already paid for the tickets.

On Episode 24 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: “Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation” and “Subarachnoid Hemorrhage During Pregnancy and Puerperium.” She also interviews Dr. Georgios Tsivgoulis about his article “Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.” Dr. Negar Asdaghi:         Let's start with some questions. 1) When during pregnancy is an intracranial aneurysm at the highest risk of rupture? 2) What does the presence of covert brain infarcts mean in the setting of atrial fibrillation? 3) And, finally, how is the inflammatory form of cerebral amyloid angiopathy different from the classic CAA form, and why is it important to differentiate between the two? We'll be answering these questions and much more in today's podcast. We're covering the latest in cerebrovascular disorders, and this is the best in Stroke. Stay with us. Welcome back to another issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. Together with my co-editors, Drs. Nastajjia Krementz and Eric Goldstein, here's our article selection for the month of January. Symptomatic intracerebral hemorrhage is a feared complication of reperfusion therapies in acute stroke, so there's a lot of interest in looking for predictors of development of this complication, especially when you're making decisions for pursuing endovascular therapy. For many years now, we've known about some of these predictors, such as presence of a large infarct core and high blood glucose levels. But in the recent years, other radiographic markers of tissue viability, such as a poor collateral status and unfavorable venous outflow profile, have been shown to be predictors of post-reperfusion hemorrhagic transformation. In this issue of the journal, we learn about another imaging marker that can potentially predict parenchymal hemorrhage occurrence post-endovascular therapy, which is high hypoperfusion intensity ratio, or HIR, as measured by perfusion imaging. What is HIR? It's a long name for a simple ratio that can easily be measured by dividing the volume of tissue with Tmax delay of over 10 seconds to the volume of tissue with Tmax delays of over 6 seconds. Simply put, Tmax 10 divided by Tmax 6. These volumes, as you know, are typically provided to us by almost all post-processing perfusion softwares, and so this ratio can be easily calculated in the acute setting. So, in this paper led by Dr. Tobias Faizy from University Medical Center in Hamburg and colleagues, we learned that higher hypoperfusion intensity ratios are strongly associated with parenchymal hemorrhage occurrence after endovascular therapy. So, in summary, HIR, that is a quantitative ratio, can be used as a marker to risk stratify patients that are undergoing endovascular therapy in terms of helping us predicting the risk of development of intracerebral hemorrhage after reperfusion therapies. In a separate study in this issue of the journal, we read a very interesting paper titled "Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk." How are intracranial aneurysms even related to anti-epileptic drugs? Well, first of all, it's been known for a long time based on genome-wide association studies that there are multiple common genes that are associated with increased risk of intracranial aneurysm development. Now, some of the largest genetic studies to date have shown pleiotropy between genetic causes of development of intracranial aneurysms and genes encoding targets for anti-epileptic drugs. Now that's a fascinating finding because finding commonalities between these genes may help find new treatment targets for intracranial aneurysms. So, in this paper in this issue of the journal, the investigators from the University Medical Center in Utrecht found an association in the expression of anti-epileptic drug target gene CNNM2 and intracranial aneurysm risk. They found that certain anti-epileptic drugs, such as phenytoin, valproic acid, and carbamazepine, that are expected to lower CNNM2 levels in the blood may subsequently lead to a lower risk of development of intracranial aneurysms. And, of course, a reasonable follow-up study to this would be to investigate whether persons exposed to these anti-epileptic drugs have indeed a lower risk of unruptured intracranial aneurysms and subarachnoid hemorrhage, and how variation in CNNM2 expression can lead to development of aneurysms. Bottom line, CNNM2 may be a relevant drug target for treatment of cerebral aneurysms. As always, I encourage you to review these papers in detail in addition to listening to our podcast today. My guest on the podcast today is the Chairman of Neurology at the University of Athens, Dr. Georgios Tsivgoulis. He joins me all the way from Greece to talk about cerebral amyloid angiopathy-related inflammation, or CAA-ri. He's a remarkable researcher, and I can say with absolute confidence that we cannot find a better summary of this very tough topic elsewhere. He ends the interview with an intriguing account of the early description of dementia in Greek mythology. But first, with these two articles. What are covert brain infarcts, or CBIs? Are these the John Wick or the James Bond of the stroke world? After all, they operate undercover. They're ominous and attack without warning. That's probably why they're also called silent infarcts. Now, whatever we call them, we need to know how prevalent they are and what does their presence actually mean. Let's dive into this topic. For at least two centuries, if not longer, we've known about covert brain infarcts. Early description of these lesions is credited to Amédée Dechambre, a medical intern at Salpêtrière Hospital in Paris who noted that there are strokes that can cause symptoms like hemiplegia, but also strokes that are asymptomatic, or so he thought at the time. In the modern times, while we agree with our pathology forefathers that CBIs are different from symptomatic strokes, we also know that they are not entirely asymptomatic. The symptoms can be subtle and tend to sneak up on the patient, but what is clear is that amassing of covert brain infarcts results in an overall decline in cerebrovascular reserve of the brain. With the advent of neuroimaging, we now know that CBIs are age-dependent and prevalent, seen in almost 10 to 30% of even healthy adults, but much more prevalent in those with vascular risk factors, and they can be caused by nearly the entire spectrum of neurovascular disease, including large vessel, small vessel disorders, cardioembolism, and others. Now, how do these covert infarcts catch up in those with atrial fibrillation? Neuroimaging studies have shown that patients with A-fib, especially those untreated, have a higher percentage of embolic-appearing CBIs, and conversely, those with embolic formed pattern of CBIs are more likely to have undiagnosed A-fib. So the question is, what's the significance of CBI in those with confirmed A-fib? In this issue of the journal, Dr. Do Yeon Kim from Seoul National University and colleagues help us answer this question using the EAST-AF, which stands for East Asian Ischemic Stroke Patients With Atrial Fibrillation Study. So, the paper included over 1300 patients with A-fib and first-ever stroke without a prior history of TIA or stroke. And then they categorized these patients into those who had evidence of CBI on neuroimaging and those who didn't. So, what did they find? Forty-two percent of patients with A-fib and first-ever stroke had evidence of covert brain infarcts on neuroimaging. Let's think about it for a moment. These patients presented with what was thought to be their first-ever stroke, not knowing they already had some in their brain. Now, what makes things really worse is that over a quarter of these subjects had more than just one covert infarct. Not surprisingly, those with CBI tended to be older, had higher blood pressure, and had worse white matter hyperintensity burden. This is kind of expected and also not expected was the fact that most of these covert infarcts were actually embolic in pattern. Over 60% of them were embolic. Another 14% of cases had combined embolic and non-embolic-appearing CBIs. Now, overall, the one-year incidence of ischemic stroke and all-cause mortality was higher in those that had CBIs at baseline. When they started looking at the specific patterns of CBIs, those embolic-appearing CBIs had a threefold higher risk of recurrent ischemic stroke, whereas those with non-embolic-appearing covert infarcts had oddly a higher all-cause mortality rate but not recurrent ischemic stroke. And finally, just briefly, the authors noted that the addition of CBIs to the classic CHA2DS2-VASc score didn't meaningfully otherwise statistically improve the scoring metrics, so they left it at that. So, the take-home message is that 42% of A-fib patients presenting with first-ever stroke actually had prior strokes without even knowing based on this study. And most of these strokes were embolic-appearing, and these covert brain infarcts can be used as predictors of future clinical strokes in this population. Strokes should be the last thing to worry about when we think of pregnancy. In the United States, around 30 in 100,000 women, unfortunately, experienced a stroke during pregnancy, and between 6 to 8 in 100,000 deliveries are complicated by subarachnoid hemorrhage. What's the most common cause of pregnancy-associated subarachnoid hemorrhage? In the general population, close to 80% of subarachnoid hemorrhage cases are aneurysmal. Is this true for the pregnant population as well? And importantly, what's the contemporary incidence trend, risk factors, and outcomes of pregnancy-related subarachnoid hemorrhage? In this issue of the journal, Dr. Korhonen and Petra [Ijäs] and their colleagues from the Departments of Neurology and Obstetrics and Gynecology at Helsinki University Hospital will give us the answers to some of these questions through a nationwide population-based study in Finland. So, they looked at over one and a half million pregnant women who gave birth during a 30-year time period between 1987 to 2016. Subarachnoid hemorrhage was identified through appropriate ICD codes and then further adjudicated based on confirmatory information, including neuroimaging and data from lumbar puncture. A total of 57 cases of pregnancy-related subarachnoid hemorrhage was identified in this paper. The mean age of women was 33, ranging from 23 to 45, and the clinical presentation was typical for subarachnoid hemorrhage, including thunderclap headache and mild neurological symptoms. So, what did they find? So, first off, in terms of general observations, the overall incidence rate of pregnancy-related subarachnoid hemorrhage in this study was 3 over 100,000 deliveries. This is almost half the incidence rate reported from the nationwide registries in the United States. Seventy-seven percent of pregnancy-related subarachnoid hemorrhage cases were aneurysmal, so very similar to the general population. The other 23% were non-aneurysmal cases, but it's important to note that 40% of those non-aneurysmal cases also had vascular etiologies, so etiologies such as moyamoya syndrome, postpartum angiopathy, AVM, to name a few. Like non-pregnant patients with subarachnoid hemorrhage, the aneurysmal cases were sicker patients in general. They had a lower GCS at presentation, higher Hunt and Hess scores, and required more ICU admissions. The next finding is very important because it actually shows that development of subarachnoid hemorrhage during pregnancy significantly impacted obstetrical care. A total of 66% of women with subarachnoid hemorrhage during pregnancy ended up having a C-section and a high percentage of these cesarean sections were actually elective. This is in contrast with subarachnoid hemorrhages in the postpartum period where 67% of women had spontaneous vaginal deliveries. The other important finding of the paper was really highlighting the differences between pregnancy-related aneurysmal versus non-aneurysmal subarachnoid hemorrhages. We already talked about how, in general, aneurysmal cases had more severe neurological presentations, so, not surprisingly, they also had worse outcomes with a mortality rate of 16% for the aneurysmal subarachnoid hemorrhage cases, and only 68% of women with pregnancy-related aneurysmal subarachnoid hemorrhage reached a favorable outcome, which was defined in this study as modified Rankin Scale of 0 to 2. Other important differences included the fact that the incidence of aneurysmal subarachnoid hemorrhage increased towards the end of pregnancy and was highest in the third trimester. This ties in with the findings from prior studies all indicating that rupture of an aneurysm is most common in the third trimester. By contrast, the incidence of non-aneurysmal subarachnoid hemorrhage peaked in the second trimester in this study. And finally, in terms of risk factors, first let's talk about age. The incidence rate of pregnancy-associated subarachnoid hemorrhage increased with age of the mother. So, in this study, there were no cases noted amongst women aged below 20 years of age to an incident rate of 12 per 100,000 deliveries among women aged 40 years or over. So that's a fourfold increase from the overall incidence rate of pregnancy-related subarachnoid hemorrhage, and very important point that we learned from this paper. Apart from age, smoking beyond 12 weeks of gestation and hypertension were also independent factors associated with pregnancy-related subarachnoid hemorrhage. So, overall, hypertension, smoking are bad and are significant risk factors for pregnancy-related subarachnoid hemorrhage. And if we have to remember just one thing from this paper, let it be this one: The rupture of an aneurysm is most common in the third trimester of pregnancy. Cerebral amyloid angiopathy, or CAA, is an important cause of intracranial hemorrhage and refers to deposition of β-amyloid fibrils in the wall of the small- and medium-sized cerebral blood vessels, mostly involving cortical and leptomeningeal arteries. It is believed that the deposition of β-amyloid results in architectural disruption of the blood vessels, which then leads to perivascular leakage. That's the pathophysiological mechanism behind the development of cerebral microbleeds. And this process, of course, can cause frank vascular rupture resulting in cortical intracerebral hemorrhage or development of high-convexity subarachnoid hemorrhages. It is important to note that varying amounts of perivascular inflammation, that is inflammation surrounding β-amyloid-laden blood vessels, may be present in some CAA cases, rendering them the designation of inflammation-related CAA. However, frank vasculitic destruction of the vessel wall, such as what is found in amyloid-β-related angiitis, or ABRA, and primary angiitis of the central nervous system, is usually absent in most CAA-related inflammation cases. How these entities are best defined, diagnosed, and treated is subject of intense research. In this issue of the journal, in the study titled "Clinical, Neuroimaging, and Genetic Markers in CAA-Related Inflammation," Dr. Georgios Tsivgoulis and colleagues take us through a systematic review and meta-analysis of published studies of patients with CAA-related inflammation. I am joined today by Dr. Tsivgoulis himself to discuss this paper. He's a Professor of Neurology and Chairman of the Second Department of Neurology at the University of Athens School of Medicine. Dr. Tsivgoulis is the residency program director and the director of cerebrovascular fellowship program with extensive research and expertise in the field of stroke. Good morning, Georgios, and welcome to our podcast. Dr. Georgios Tsivgoulis: Good morning, Negar. I'm delighted to be here and delighted to present our findings, on behalf of all our co-authors. Dr. Negar Asdaghi:         Thank you very much for being here and congrats again on the paper. So, Georgios, let's start with this interest that's going on with using clinical and radiographic features to make the diagnosis of CAA-related inflammation in contrast to moving ahead and performing brain biopsy. Can you please start us off with a brief review of the newly proposed clinico-radiographic criteria for this condition, please? Dr. Georgios Tsivgoulis: Yes. As you mentioned, Negar, CAA-ri is a distinct, however, rare subset of cerebral amyloid angiopathy. Firstly, Greenberg and the Boston group published in Neurology in 2007 a paper highlighting that a diagnosis of a probable CAA-ri patient could be made on the basis of characteristic clinical and neuroimaging findings without requiring a biopsy. Following this observation, Chung and colleagues in 2010, in a seminal paper in JNNP, proposed the first diagnostic criteria for probable and definite CAA-ri. For the definite diagnosis, besides the typical clinical presentation with headache, encephalopathy, focal neurological signs and seizures, and the characteristic neuroimaging findings with T2 or FLAIR hyperintense asymmetric white matter lesions complicated with microbleeds and leptomeningeal or parenchymal gadolinium enhancement, and histopathological confirmation with amyloid deposition within cortical leptomeningeal vessels associated with perivascular, transmural or intramural inflammation was also required. The latest criteria developed in 2015 by Auriel and colleagues that were published in JAMA Neurology using a validation study modified the current criteria for the diagnosis of CAA-ri. In this paper, the author supported the use of empirical immunosuppressive therapy, avoiding brain biopsy, for patients meeting the criteria proposed for probable CAA-ri. They suggested that a brain biopsy should be considered in empirically treated patients who failed to respond to corticosteroid therapy within three weeks. The criteria by Auriel and colleagues are widely applicable in everyday clinical practice, and we also use this criteria for the inclusion of studies in our current meta-analysis. I would like to highlight for our audience that the latest criteria for CAA-ri were published in 2015 by Auriel and colleagues. However, these are different for the criteria for cerebral amyloid angiopathy than the latest criteria were published in 2022 in Lancet Neurology, OK? Dr. Negar Asdaghi:         Georgios, that was a great start for this interview. You had mentioned a lot of information here. I just want to highlight what you just said. So, we are using for this meta-analysis, the latest criteria in CAA-related inflammation published in JAMA by Auriel and colleagues. That's slightly different than, we're not referring to the 2022 criteria of cerebral amyloid angiopathy. It's an important distinction. We're going to talk about this a little more as we go through the interview, but I want to come back to your current paper and start from there. Can you please tell us about the importance of this paper, why doing a meta-analysis was important in your view, and tell us a little bit about the studies that were included in your paper? Dr. Georgios Tsivgoulis: Yes, thank you for that question. CAA-ri is an increasingly recognized entity since the recent diagnostic criteria by Auriel and colleagues published in 2015. In collaboration with the greater availability of the high-resolution MR, we can have now a reliable non-invasive diagnosis of possible or probable CAA-ri, avoiding the risk of brain biopsy. However, I need to highlight that the early diagnosis remains a great challenge for the clinicians and neurologists. Searching the literature, we observe that there is scarce data regarding the prevalence of the distinct clinical, neuroimaging, and genetic markers among patients diagnosed with CAA-ri. We believe that pooling all this information in the current meta-analysis would be very helpful for every clinician, increasing a comprehensive understanding of this rare cerebrovascular disorder. Consequently, we conducted this meta-analysis including 21 studies that recruited a total of 378 patients with CAA-ri. Our study involved only 4 prospective and 17 retrospective hospital-based cohorts of patients diagnosed with CAA-ri based on autopsy or biopsy or on the recent Auriel diagnostic criteria that do not require autopsy or biopsy. Due to limited data in the literature regarding this entity, we had to include only small cohort studies with at least five patients in our meta-analysis. We excluded case reports and case series with less than five patients. This is, by far, the largest available sample of CAA-ri patients in the literature. Dr. Negar Asdaghi:         OK, great. So, let me just recap this, more so for myself. So, we have 21 studies, and you excluded studies that included less than 5 patients. So, practically speaking, case reports. Dr. Georgios Tsivgoulis: Yes, and single-case reports. Dr. Negar Asdaghi:         Yes. And practically speaking, of the total number of patients that are included in this meta-analysis, you have 378 cases, and basically the diagnosis of CAA-related inflammation was either based on the newly proposed criteria or based on biopsy-confirmed or autopsy cases. Dr. Georgios Tsivgoulis: Which is the standard criteria. Dr. Negar Asdaghi:         So, now, I'm dying to ask you about these clinical and radiographic characteristics of patients with CAA-related inflammation in this meta-analysis. Dr. Georgios Tsivgoulis: The mean age of patients in the included studies was approximately 72 years old, and there was no obvious gender predominance. Fifty-two percent of the patients were of female sex. In our study, 70% of the included patients presented with cognitive decline, which was the most common neurological manifestation, while 50% of the total sample had focal neurological signs and 54% encephalopathy presentation. Symptoms such as headache and seizures were less common, 37 and 31% respectively. With regard to the radiological findings, hyperintense T2 FLAIR white matter lesions were very, very common in 98% of our patients, and they were also complicated with lobar cerebral microbleeds, with a prevalence of 96%, and these two were, by far, the most prevalent neuroimaging findings, that white matter hyperintensities coupled with a cerebral microbleed. The pooled prevalence rates of gadolinium-enhanced lesions was 54%, and also the prevalence of cortical superficial siderosis was 51%, which is also very high in this cohort of patients with CAA-ri. Dr. Negar Asdaghi:         OK. So many of the features Georgios said, you mentioned, from presence of white matter hyperintense lesions on T2 FLAIR to presence of cortical microbleeds or superficial siderosis, these features are also seen in patients with cerebral amyloid angiopathy. What are some of the important differentiating features between the two conditions? Dr. Georgios Tsivgoulis: Yes, this is an excellent clinical question. First of all, the lower age threshold for CAA-ri is 40 years old, whereas in cerebral amyloid angiopathy, the lower age threshold is 50 years. So, patients who are younger than 50 years can be diagnosed with CAA-ri, but they cannot be diagnosed with CAA. Another issue is that comparing the result of this meta-analysis with another recent meta-analysis focusing on CAA, on cerebral amyloid angiopathy, that our international multi-collaborative group published in Stroke in 2002, we also evaluated the presence of clinical phenotypes and radiological markers among patients with cerebral amyloid angiopathy. We have documented that transient focal neurological episodes are much more common in patients with cerebral amyloid angiopathy in contrast to patients with CAA-ri. These episodes, which are called TFNEs, transient focal neurological episodes, are attributed to cortical subarachnoid hemorrhage or cortical superficial siderosis. So, I think this is another important clinical distinction. The most important, however, differentiating features between the two entities are neuroimaging markers, in specific, in particular, T2 FLAIR hyperintense unifocal or multifocal lesions with mass effect. These are the most prevalent neuroimaging features among patients with CAA-ri, but they're very seldomly described in patients with cerebral amyloid angiopathy, in patients with CAA. Another characteristic neuroimaging finding very indicative of the inflammation is the leptomeningeal or parenchymal gadolinium enhancement. This finding has been very rarely described in patients with non-inflammatory cerebral amyloid angiopathy. So, the clinical distinction is not so solid. However, the neuroimaging distinction would provide us with very strong information that can help us differentiate these two conditions. Dr. Negar Asdaghi:         Excellent points, I have to say, golden points, not just excellent points. I'm going to try to recap this and see if I understood it correctly. So, for our listeners, we have two conditions that potentially have many common points. One is the cerebral amyloid angiopathy, and the second one, which is obviously the subject of this interview, is cerebral amyloid angiopathy-related inflammation. The most important differentiating factors between the two are actually the neuroimaging features, as Georgios mentioned. So, the first feature that was mentioned is presence of T2 FLAIR hyperintense lesions. Some of them are large and have actually mass effects. This feature is rarely seen in patients with CAA, and it's an important radiographic factor that is seen in patients with CAA-related inflammation. The second distinguishing feature was leptomeningeal enhancement, again, rarely seen in non-inflammatory CAA, but was seen in a significant proportion of patients with CAA-related inflammation. These were the neuroimaging features. You also mentioned two other factors. The median age of CAA-related inflammation was lower than CAA. That can be helpful. And also the entity of transient focal neurological episodes, or TFNE, is rarely seen in inflammatory cases of CAA, whereas it is described in cases with cerebral amyloid angiopathy and mostly related to development of either cortical subarachnoid hemorrhage or cortical superficial siderosis. I think I got this all, correct? Dr. Georgios Tsivgoulis: Excellent. Dr. Negar Asdaghi:         All right, so let's come now to the genetics of CAA. The apolipoprotein E gene is associated with the presence of amyloid angiopathy and development of lobar intracerebral hemorrhage, and we've learned about this in cases with cerebral amyloid angiopathy. Is there an association with ApoE, and did you find anything in this meta-analysis? Dr. Georgios Tsivgoulis: Another very exciting question. In 2007, there was a first report that the apolipoprotein ε4 homozygosity may be considered a risk factor for CAA-ri, and there was a strong correlation reporting a high prevalence of 77% of this apolipoprotein ε4 alleles among patients with CAA-ri. To justify this correlation, the hypothesis was that an underlying pathogenic mechanism, which increases the amyloid-β deposition and has a pro-inflammatory effect, may be suspected as the cause of this disorder. The largest, however, prospective cohort of CAA-ri patients conducted by Antolini and colleagues and was published in 2021 in Neurology, reported a much lower prevalence of apolipoprotein ε4 carriers accounting for 37%, 23% heterozygotes and 14% homozygotes. So, we also documented a pool prevalence of apolipoprotein ε4 homozygosity of 34%. So, we did not confirm the initial finding of 77%. However, in our meta-analysis, the homozygosity was 34%, and we need to have a cautious interpretation of these results because data is limited, and we need larger future population-based studies and in larger cohorts to evaluate the prevalence rate of these specific genetic markers. So, we can confirm an association between apolipoprotein ε4 homozygosity, however not as strong as originally reported in 2007. Dr. Negar Asdaghi:         OK. So, Georgios, thank you. And again, very important factor to keep in mind for our clinicians listening in. Unfortunately, based on what you mentioned, we don't have yet a genetic marker to, for sure, tell us if we're dealing with CAA-related inflammation, yes or no, as you mentioned. Just to recap, earlier on, there was studies to suggest a very strong association between apolipoprotein ε4 homozygosity and CAA-related inflammation. But later on, this was not confirmed by subsequent studies, and in your meta-analysis, you found 34% ApoE ε4 homozygosity amongst patients with CAA-related inflammation and could not confirm that original high association. OK, so with all of that, it's a lot of information. I have to go to the next question regarding controversies involving the levels of Aβ40, Aβ42, and P-tau proteins in CSF in the setting of CAA-related inflammation. Can you please tell us more about these biomarkers? Dr. Georgios Tsivgoulis: Yes. The overlap of Alzheimer's disease and CAA can be attributed to the coexistence of some degree of cerebrovascular amyloid deposition and amyloid plaque pathology, which is very common. And, of course, the evaluation of amyloid and tau proteins in CSF is of high significance for the prognosis and the evolution of CAA patients. In our previous review, we have summarized the literature and noticed that CSF concentrations of Aβ40 and, secondarily, Aβ42 were much lower in patients with cerebral amyloid angiopathy compared with Alzheimer's disease. Total tau and phospho-tau CSF levels were comparable to healthy controls in CAA and lower than patients with Alzheimer's disease. Moving now to CAA-ri, there were scarce data about these biomarkers amongst CAA-ri patients. The majority of the relevant studies have found relatively low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. In the present meta-analysis, the pooled means of biomarker levels were based on the findings of only two studies with heterogeneity, and these limit substantially the validity of our observations. However, they confirm the previous reports indicating, as I said before, but I would like to repeat, low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. Dr. Negar Asdaghi:         Perfect. So, thank you, Georgios. I'm going to recap what you said. So, we're talking about CSF biomarkers, and first what you mentioned is going back to the original studies concentrated on using these biomarkers as ways of differentiating between cerebral amyloid angiopathy and Alzheimer's disease. And very briefly, to recap what you said, in general, the levels of Aβ40 and, secondarily, Aβ42 was found to be much lower than the Alzheimer's levels in patients with CAA. Now coming to the inflammatory form of CAA, what you mentioned and what you found in this meta-analysis, practically speaking, confirmed that the levels of Aβ40 and Aβ42 in CSF are low and the levels of P-tau are high in this condition as well. So, one thing I want to ask as a secondary question to that is, that it sounds like these biomarkers are more or less similar in CAA and CAA -related inflammation, not that different. Is that correct? Dr. Georgios Tsivgoulis: It's absolutely correct. And I would also like to highlight a major limitation of the meta-analysis that we had available data from only two studies to pool the mean of these CSF biomarker levels. So, these results need to be acknowledged with caution, and we would love to repeat our meta-analysis after the publication of more studies and prospective cohorts measuring the CSF biomarkers in patients with CAA-ri. Dr. Negar Asdaghi:         OK. So, again, important to note, as you mentioned, that there's heterogeneity in data because of just paucity of information on this, but as we stand today, the biomarkers won't really help us in terms of differentiating between the two conditions that are CAA or CAA-related inflammation. And so, I think I've learned a lot from this interview myself, but I think we have to just talk briefly about the available therapies for CAA-related inflammation. Dr. Georgios Tsivgoulis: Yes. In our meta-analysis, we sought to summarize the available information regarding different therapeutic strategies and outcomes among CAA-ri patients. Our results supported our clinical experience indicating that corticosteroids represent the first-line treatment in these patients' outlook. Steroids have been associated with clinical and radiological improvement of the primary disease episode and decreased risk of subsequent relapses in patients with CAA-ri. Additional immunosuppressive therapies, including cyclophosphamide, mycophenolate mofetil, azathioprine, IVIG, or rituximab, have been also reported as adjunct therapies in selected cases with a more severe course of the disease. However, this is another limitation that needs to be acknowledged. That data regarding the treatment and the outcomes are limited and heterogeneous, which prevented us from drawing robust conclusions using a meta-analytical approach. And we believe that we need future cohort studies with prospective data validation in order to generate a proposal for a therapeutic algorithm management in these cases. Dr. Negar Asdaghi:         Thank you, Georgios. So, we have a condition that is now being more and more recognized. We now have criteria based on clinical and radiographic presentation features of patients that might help us with this diagnosis to differentiate it from cerebral amyloid angiopathy. And in terms of therapies, the idea is that the most studied drug is really just first-line therapy, that's corticosteroids. And then there's positive data regarding use of all other forms of immunosuppression, including, as you mentioned, cyclophosphamide, rituximab, and oral agents such as mycophenolate mofetil or azathioprine. We have limited information about those, but I want to highlight something you actually mentioned earlier on in the interview, which is the field is moving towards making these diagnoses based on clinical features and radiographic features that you had highlighted and actually giving patients immunosuppression early on and only move on to a biopsy if the patient had failed these therapies for a period of time, which you mentioned three weeks. So, I think it's important for us as clinicians to keep this evolving criterion and recommendations in mind. And before we end, I want to ask you a hypothetical question, Georgios. In your opinion, what's an ideal randomized trial for CAA-related inflammation in the future? Dr. Georgios Tsivgoulis: I think before going to the randomized, the ideal randomized trial for CAA-ri, and designing this trial, we need much more information regarding the underlying pathophysiological mechanisms. There are many unanswered questions. What is the diagnostic value of CSF biomarkers such as amyloid, we discussed earlier, and tau protein? And, of course, what is the value of CSF and the amyloid-β autoantibodies, if there is any? What is the value of genetic markers such as apolipoprotein E genotype and a correlation with the co-existing inflammation in CAA-ri? However, I don't want to defer this question. So, a typical answer would be that with regard to the ideal patients, we would want a young patient without comorbidities after the first manifestation of CAA-ri who has shown a good clinical and radiological response to corticosteroids in order to define the best second-line therapy. However, before answering all these questions in a clinical trial, if we can, I think that we need to understand the CSF and genetic biomarkers in order to uncover mechanisms regarding pathophysiology that can help us to design more targeted clinical trials studying novel disease-modifying treatments. Dr. Negar Asdaghi:         Thank you. Dr. Georgios, it's been a pleasure having you on the podcast, and I can say we've learned a lot. We look forward to having you back here and talk about that hypothetical randomized trial, and I'm sure one day hopefully will happen in our lifetime. Thank you for being here. Dr. Georgios Tsivgoulis: Thank you. Thank you for having me. It was a pleasure. Dr. Negar Asdaghi:         Thank you. Homer, the legendary Greek poet, described a case of dementia in his seminal work, The Odyssey, in the late eighth century before Christ. He described the cognitive decline of Odysseus's father, King Laertes. The detailed account of the king's mental decline, loss of short-term memory with retention of long-term memory combined with his depression and despair over the loss of his son, is dramatically accurate for a nearly 3,000-year-old description of dementia. Before I ended the interview, I had to use this opportunity to ask Georgios about lessons learned from ancient Greeks and this seemingly timeless disease. Dr. Georgios Tsivgoulis: Thank you for this question. King Laertes was indeed Odysseus's father, and it's a great paradigm describing dementia. However, the ancient history of dementia may be separated according to the Greek philosopher Posidonius in two periods. The first period is called dementia appearing due to old age, which is called in Greek, eros. And the second one is dementia appearing in other ages and mainly due to other reasons, called morosis. Posidonius of Rhodes was a Greek stoic philosopher of the second first century BC who strongly believed and suggested that morosis, which is that dementia appearing in younger ages due to other disorders, should be treated immediately after its onset. So, if I would like to end this podcast, I would just suggest that CAA-ri could be classified as morosis according to Posidonius. And what we could learn is that the early diagnosis is essential since the prompt initiation of corticosteroids should not be unreasonably delayed. Dr. Negar Asdaghi:         And this concludes our podcast for the January 2023 issue of Stroke. Please be sure to check this month's table of contents for the full list of publications, including a series of Focused Updates on post-stroke neurological recovery, from management of post-stroke attention deficit, neglect and apraxia to post-stroke memory decline. And with this, we end the start of our 2023 podcast series. Like all new things, a new beginning can come with new directions, and sometimes a new direction is all that we need. After all, as the legend has it, it was a direction of that falling apple back in the year 1666 that gave Isaac Newton the idea of the universal law of gravitation. Now, Isaac Newton has, without a doubt, given science some of its biggest discoveries in mathematics, physics, and astronomy. But most may not know that Newton had a pretty rough start in life. A January-born premature baby, he was thought not to survive the first few days of life. Newton had a difficult childhood, and at the age of 16, he was pulled out of school by his family and forced to become a farmer, a job he didn't like and he was miserably bad at. So, as we start a new year, let's remember that even the smartest people are not good at everything, and it does take time to find one's passion in life. Now, while things may not always be clear, what is clear is that a great way to find that center of gravity is, as always, staying alert with Stroke Alert. This podcast is produced by Wolters Kluwer and supported by the editorial team of Stroke. Our Stroke Alert podcast and production staff includes Danielle Cross, Eric Goldstein, Nastajjia Krementz, Ishara Ratnayaka, Erinn Cain, Rebecca Seastrong, and Negar Asdaghi. This program is copyright of the American Heart Association, 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

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