POPULARITY
14 episodes with vlachos
3 episodes with vlachos
4 episodes with vlachos
2 episodes with vlachos
2 episodes with vlachos
2 episodes with vlachos
2 episodes with vlachos
2 episodes with vlachos
2 episodes with vlachos
Encapsulated Cell Therapies in Sheep as a Translational Model - Trisha M. Fabijanic, B.S., University of Arizona, Tucson, AZ, Amy C. Kelly, Ph.D, University of Arizona, Tucson, AZ, Eliza H. Johnson, University of Arizona, Tucson, AZ, Delaney A. Drew, B.S., University of Arizona, Tucson, AZ, Demetri A. Vlachos, B.S., University of Arizona, Tucson, AZ, Charles W. Putnam, M.D., Ph.D., University of Arizona, Tucson, AZ, Sean W. Limesand, Ph.D., University of Arizona, Tucson, AZ, Klearchos K. Papas, Ph.D., University of Arizona, Tucson, AZ Introduction: Cell therapy has become increasingly studied for therapeutic use in drug delivery and regenerative medicine. Devices intended for implantation of cells require construction of membranes that can safely contain transplanted cells, provide a barrier to the host immune system and an outer vascularizing membrane to induce close vessel formation. Sheep make an excellent model because of their nearly comparable size, physiology, and disease profile with humans, as well as their docility, capacity for repeated blood draws, and ability to tolerate numerous implants during a single operation. In this study, sheep were implanted with devices containing allogeneic primary fetal sheep or xenogeneic Rat-2 fibroblasts to determine cell survival and immune response. Methods: Primary fetal sheep fibroblasts were isolated and cultured in RPMI. Rat-2 fibroblasts (ATCC) were cultured in DMEM. Cells were loaded into devices at different densities and transplanted subcutaneously. Sheep underwent allogeneic or xenogeneic transplantation with empty control and perforated devices transplanted as well. Devices were explanted at days 3, 7, 21 and 38 to evaluate host responses, vascularization, and cell survival through histological evaluation. Results: Sheep fibroblasts survived at different densities, confirming alloprotection with good vascularization and absence of a major foreign body response or extensive inflammation around the implants. Devices overloaded at the highest densities exhibited some host immune responses. Perforated devices exhibited a greater immune response that infiltrated the device. A robust immune response was seen around xenogeneic transplants with no encapsulated cells surviving. Conclusion: Sheep make a valuable translational animal model in cell therapy research. The results of this study concluded alloprotection in immunoisolating devices, allorejection in purposely perforated devices, and host immune response to xenogeneic transplantation, representing a feasible model for translational development of cell therapies. Future work will include continued allogeneic studies while avoiding xenogeneic rejection by incorporating immunomodulatory technologies.
Georgios Vlachos, Co-Founder of Axelar protocol and director at Axelar Foundation. Georgios received his BSc and MS Eng. in computer science at MIT. After graduation, he became part of the Algorand founding team, where he worked on the design and development of the consensus protocol and other core components. While in high school, Georgios became the first Greek to win a gold Medal at the International Mathematical Olympiad.In this conversation, we discuss:- The financial crisis in Greece and current day economy in Argentina- The power of crypto in countries without Robust banking systems- Early days of Algorand- Why Cross-chain Bridges Fall Short - True interoperability demands collaboration across projects, not just patched-together solutions.- AI agents will be the biggest users of blockchains- Could there be a world where every human has their own blockchain?- RWAs and DePIN need interoperability- Connecting on-/off-chain systems- Deploying your token on many chains with a couple of clicks- Crypto needs more applications and less infrastructure- How AI will impact cryptoAxelar FoundationWebsite: www.axelar.networkX: @axelarTelegram: t.me/axelarcommunityGeorgios VlachosX: @yorgosv_LinkedIn: Georgios Vlachos --------------------------------------------------------------------------------- This episode is brought to you by PrimeXBT. PrimeXBT offers a robust trading system for both beginners and professional traders that demand highly reliable market data and performance. Traders of all experience levels can easily design and customize layouts and widgets to best fit their trading style. PrimeXBT is always offering innovative products and professional trading conditions to all customers. PrimeXBT is running an exclusive promotion for listeners of the podcast. After making your first deposit, 50% of that first deposit will be credited to your account as a bonus that can be used as additional collateral to open positions. Code: CRYPTONEWS50 This promotion is available for a month after activation. Click the link below: PrimeXBT x CRYPTONEWS50
Katia Vlachos is a reinvention coach, speaker, meditation teacher and bestselling author of Uncaged: A Good Girl's Journey to Reinvention. With a master's from the Harvard Kennedy School and a PhD from the RAND Graduate School, Katia began her career as a policy analyst before pivoting into coaching, specialising in helping women to reinvent their lives and pursue their aspirations without being weighed down by guilt or overwhelm. Based in Switzerland, Katia has also spent over 25 years' as an expat and is an expert in cross-cultural transitions and global mobility, which led her to write her first book A Great Move: Surviving and Thriving in Your Expat Assignment. In this episode you will hear: 00:00:00 Intro 00:02:55 Identifying your cage 00:05:15 Katia's memoir process 00:08:27 Katia's ‘Good Girl' story 00:16:49 Learning to use the heart 00:24:00 Unlearning that love requires earning and embracing unconditional love 00:28:00 Healing the mind and body connection 00:38:00 Be alert! Your cages will show up 00:41:00 Creating home, belonging and your tribe 00:52:00 Katia's Heartprint Those with ears, let them hear. Always love Ryan Connect with Katia Website: https://www.katiavlachos.com/ Facebook: https://www.facebook.com/KatiaVlachosCoach LinkedIn: https://www.linkedin.com/in/katiavlachos/ Instagram: https://www.instagram.com/katia.vlachos/ Book: https://uncaged.net/ Connect with Always Better than Yesterday Website: https://abty.co.uk/ Instagram: https://www.instagram.com/alwaysbetterthanyesterdayuk/ LinkedIn: https://www.linkedin.com/company/abty/ Facebook Community: https://www.facebook.com/groups/weareabty Join our mail list here for exclusive content here: https://abty.co.uk/contact Sign up for our coaching here: https://abty.co.uk/coaching Thank you to our supporters Exhale Healthy Coffee. Exhale is the first coffee to be sourced, roasted and lab tested specifically to maximise its antioxidant and anti-inflammatory potency. An independent lab test showed one cup of Exhale coffee has the same antioxidant power as 1.8kg of blueberries or 55 oranges! Get £10 off your first bag when you visit https://exhalecoffee.com/abty Please email your questions and comments to podcast@abty.co.uk #KatiaVlachos #Uncaged #Reinvention
Chris Colluccio & Lauren Vlachos LIVE on LI in the AM w/ Jay Oliver by JVC Broadcasting
Text Jason @ Leadership VoyageDr. Katia Vlachos is a reinvention coach, speaker, and author of A Great Move: Surviving and Thriving in Your Expat Assignment, recognized as a Financial Times Business Book of the Month in June 2018. With a Masters from the Harvard Kennedy School and a PhD from the RAND Graduate School, Katia began her career as a policy analyst. Her work has been featured in the New York Times, Harvard Business Review, and other media outlets globally.Through her coaching, writing, or transformative retreats, Katia is committed to empowering women to chart their own ambitious paths towards a fulfilling, uncaged life. She lives in Zurich, Switzerland, with her family. Her upcoming book, "Uncaged: A Good Girl's Journey to Reinvention," explores the themes of breaking free from social conditioning, making bold choices, and reclaiming one's authentic self.https://www.katiavlachos.com/https://www.linkedin.com/in/katiavlachos/=====Expatriation Once you leave where you grew up, it's hard to find that sense of belonging again You're a foreigner in a new place (expatriation) and also when you go back “home” (repatriation) Learn to be at home wherever you are Both you and the places you leave behind change If you go back home, approach it as another expatriation Learn to be at home with people rather than places“A Great Move” Book People who voluntarily move do so for 3 primary reasons: career/prospects, love, adventure The attitude of the adventurer is wonderful but can lead to being unpreparedUnderstanding transition stages (honeymoon, crisis, recovery, adjustment) Personality traits affect the emotional impact Creating home is a key pillar of feeling stable and grounded Being Stuck Factors that affect us: values, expectations, growth, partner, environment Some circumstances can keep us stuck, but 90% is about how we approach it (Mindset) Focusing on the barriers versus focusing on your goals or vision Conditioning (upbringing, labels, roles, events) matters and shapes usReinvention Roadmap Establish a healthy baseline Reconnect with ourselves Align with values, vision, and purpose Build momentum with baby steps Deal with saboteurs Sustain the reinvented personLeadership Voyagesite: leadership.voyageemail: StartYourVoyage@gmail.comyoutube: https://www.youtube.com/@LeadershipVoyagelinkedin: https://www.linkedin.com/in/jasonallenwick/, https://www.linkedin.com/company/leadership-voyage-podcast/music: by Napoleon (napbak)https://www.fiverr.com/napbakvoice: by Ayanna Gallantwww.ayannagallantVO.com========== Instacart - Groceries delivered in as little as 1 hour. Free delivery on your first order over $35.Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.
*** Andau Medical's Loupes: https://tr.ee/4plS2nOvmx Haley is joined again with friends from the CDA to bring on special guest, Dr. Anthoula Vlachos. She is currently a dentist practicing in California and shares why she chose to go into dentistry as a second career path, her involvement in organized dentistry, advice for D4s, and advice for new dentists. Engage with the podcast on Instagram: https://www.instagram.com/dentaldownloadpodcast/ Haley's Instagram: https://www.instagram.com/haleyschultzdental/ Make your podcast on Riverside: https://www.riverside.fm/?utm_campaign=campaign_5&utm_medium=affiliate&utm_source=rewardful&via=haley
Metropolitan Hierotheos of Nafpaktos wrote this book about Elder Sophrony as an expression of gratitude for his long association (17 years) with the Elder and “to share with readers the spiritual wealth that I unworthily received”. The first part of the book is a spiritual portrait of Elder Sophrony. After a brief survey of his theology, the author examines the Elder's writings in the light of the experience of saints of the Church, particularly St Paul, St Symeon the New Theologian and St Gregory Palamas, thus placing his teaching in a wider context. There is a careful analysis of the Elder's correspondence with David Balfour, which reveals “many subtle details of the spiritual life” but also how “a genuine spiritual father guides those entrusted to him”. The second part of the book records what the author learnt and experienced during visits to the Monastery of St John the Baptist in meetings and informal conversations with the Elder and as a concelebrant at the Divine Liturgy. Over the years he carefully recorded the Elder's words and amassed an archive of notes that he publishes here. The subjects covered reflect both Father Sophrony's and the author's personal and pastoral concerns and include prayer (particularly the Jesus Prayer); monasticism and obedience; priesthood and the temptations it brings; giving spiritual guidance; the problems facing those who become Orthodox; and family life. The discussions also shed light on theological issues close to the Elder's heart. The book shows us a “great hesychast and theologian, but also a wise, discerning and prophetic spiritual father” and brings us closer to the man in Christ. --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Imagine a world where you could identify triggers and choose healthier responses, leading to profound personal growth. Welcome to our enlightening conversation with Dr. Katia Vlachos and Dr. Michael Watkins.Dr. Katia Vlachos is a coach, author, and speaker who helps ambitious women make bold decisions and live fulfilling lives. She is the author of A Great Move: Surviving and Thriving in Your Expat Assignment. She has written for Harvard Business Review, Huffington Post, Thrive Global, and Medium. She is based in Zurich, Switzerland, and works with clients all over the world.Dr. Michael Watkins is a professor of leadership and organizational change at IMD Business School. He is the author of the international bestseller The First 90 Days, which has been called "the onboarding bible" by the Economist. He is based in Lausanne, Switzerland.These esteemed guests enlighten us on the captivating world of Schema Therapy and its applications. They unpack the intricate Schema Trigger Mode Framework and elucidate how this cutting-edge approach can address issues such as personality disorders, chronic depression, and anxiety in coaching sessions. They also underscore the importance of maintaining clear boundaries between coaching and therapy.Taking a deep dive into modes and schemas, we learn how these are different versions of ourselves that emerge when we experience triggers. We also come to understand how unyielding standards and other schemas can manifest in leaders and professional women, empowering us to make conscious choices about our responses. We're not just talking theory here, we share practical techniques to help clients identify and interrupt their automatic responses, bringing tangible change in their lives. The conversation about positive intelligence in coaching, specifically the correlation between gremlins, saboteurs, and modes is sure to leave you intrigued.In the final section, we venture into the empowering side of Schema Therapy, emphasizing the importance of comprehending and addressing our own schemas. This episode isn't just a discussion, it's a stepping stone on your journey of self-improvement. Don't miss out on this chance to revolutionize your coaching practice or personal growth journey!Watch the full interview by clicking hereFind the full article here: https://bit.ly/BTP-KVMWLearn more about Katia and MichaelKatia's gift to our listeners: Take the Break Free Quiz to understand where you feel trapped in your life and how you can break free here: https://www.katiavlachos.com/break-free-quiz Grab your free issue of choice Magazine here - https://choice-online.com/ In this episode, I talk with Dr. Katia Vlachos and Dr. Michael Watkins about their article published in our September 2023 issue.
In this week's episode of Eight Ounce (8oz) The Podcast we are joined by my friend Stephan. He's a Greek Queen's kid who not only is a commercial airline pilot, but owns his very own coffee company (Rise With Apollo) Join us as we chat about Coffee, Film Photography and fear of flying. Follow us on Instagram : @eightounce.podcast
Part 4 --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Part 3 --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Part 2 --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Cure of the Passions Dispassion General Methods of Healing the Three Parts of the Soul Many Stages & Degrees of Dispassion Orthodox Pathology Particular Methods for Particular Passions Paths Leading to Dispassion Suggestions from the Fathers Therapeutic Methods Applying to All the Passions Anti-Hesychasm Devotion to Stillness Hesychasm Hesychia as a Method of Healing Noetic Hesychia & Repentance Stillness of the Soul --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
The Science of Spiritual Medicine (Part 1) - Orthodox Psychotherapy in Action table of episodes to follow --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Detailed table of contents of episode segments to follow. Kind thanks for your patience. Daily updates. --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Orthodox Christianity as a Healing Science What Therapy Is? table of contents for episode to follow --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Part 6 Table of Contents for episode to follow --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Part 5 Chapter 9 - The Keeper of the Holy Mountain --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
https://t.me/athoniteaudio/3955 Part 4 Table of Contents for this Episode to follow. --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Part 3 --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
(Part 2) Table of Contents to follow. --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
St Gregory Palamas as a Hagiorite The book St Gregory Palamas as a Hagiorite covers the life, work and teaching of St Gregory Palamas and relates them to his identity as a monk of the Holy Mountain. Having first acquired personal knowledge of God, St Gregory Palamas subsequently became an unerring theologian, preacher and teacher of the theology of the uncreated Light, as well as of social justice through practicing Christ's commandments. Involved in a major controversy with representatives of a legalistic, anti-hesychastic tradition originating from the West, St Gregory Palamas proved that prayer of the nous in the heart and the vision of the uncreated Light is part of the tradition of the Church. The teaching of St Gregory Palamas has made an inestimable contribution to Orthodoxy and is very relevant to our times. --- Support this podcast: https://podcasters.spotify.com/pod/show/athonite-audio/support
Pour cet épisode d'Xpresso nous avons eu la chance de nous entretenir avec Régis Vlachos, auteur et comédien de la pièce “Jacques & Chirac” à voir actuellement au Théâtre de la Contrescarpe (Paris 6e). Une comédie mordante qui retrace le parcours haletant d'un homme devenu président malgré lui. Dans une mise en scène signée Marc Pistolesi , trois comédiens font virevolter plus de vingt personnages : Bernadette, Claude, Mitterrand, Giscard, Sarkozy, Pasqua, Dassault et toute la bande de Jacques Chirac. Une véritable plongée dans les dossiers noirs de la Ve République. La plume incisive de Régis Vlachos ne manque pas de mettre à nu ce personnage aussi aimable que grinçant.
Konstantinos Vlachos is a linguist, Ph.D. candidate, and the CEO of Glossonauts, a company that offers customized online lessons for people of all ages interested in learning Greek. Glossonauts teaches a brain-friendly methodology to learn Greek, called Suggestopedia. Konstantinos discusses where we've gone wrong with teaching all languages, how we can learn more easily, and how his passion's origin is incorporated in what he does today.Website:www.glossonauts.comCatch even more of Grounded in Greek Podcast Shop: www.grounded-in-greek-podcast.myshopify.com Social Media: www.instagram.com/grounded.in.greek/ Contact: groundedingreek@gmail.com
In this Their Story podcast episode, Sean Martin and Marco Ciappelli are joined by Dimitri Vlachos, CMO at Brinqa, a company focused on vulnerability risk management. Dimitri discusses how the Brinqa platform helps businesses consolidate their findings and vulnerabilities from various tools, manage the remediation process, and communicate risk to business owners. The platform aims to mature cybersecurity programs by breaking down siloed views and enabling security leaders to discuss vulnerabilities in the context of business impact.The conversation highlights the importance of translating cybersecurity issues into business terms and emphasizes the need for consolidation and effective communication between different teams and tools. Dimitri shares how Brinqa is addressing this challenge by helping organizations tie their various cybersecurity tools together and better align their cybersecurity strategies with business objectives.During the RSA Conference, Dimitri expects to see growing interest in consolidating and managing security tools more effectively. He also anticipates an increasing number of professionals looking to change traditional vulnerability management approaches and better address the risks associated with different tools. If you are intrigued by the conversation, you can find Brinqa in the North Hall during the conference or book a meeting with the team to learn more.Note: This story contains promotional content. Learn more: https://www.itspmagazine.com/their-infosec-storyGuest:Dimitri Vlachos, CMO at Brinqa [@brinqa]On Linkedin | https://www.linkedin.com/in/dvlachos/On Twitter | https://twitter.com/DimitriVlachosResourcesLearn more about Brinqa and their offering: https://itspm.ag/brinqa-pmdpConnect with Brinqa during RSA Conference: https://itspm.ag/brinqa6gp5Hear more stories from Brinqa: www.itspmagazine.com/their-stories/see-all-of-your-security-findings-in-one-place-act-on-them-precisely-a-collection-of-brinqa-stories-from-rsa-conference-2023For more RSAC Conference Coverage podcast and video episodes visit: https://www.itspmagazine.com/rsa-conference-usa-2023-rsac-san-francisco-usa-cybersecurity-event-coverageAre you interested in telling your story?https://www.itspmagazine.com/telling-your-story
In this Their Story podcast episode, Sean Martin and Marco Ciappelli are joined by Dimitri Vlachos, CMO at Brinqa, a company focused on vulnerability risk management. Dimitri discusses how the Brinqa platform helps businesses consolidate their findings and vulnerabilities from various tools, manage the remediation process, and communicate risk to business owners. The platform aims to mature cybersecurity programs by breaking down siloed views and enabling security leaders to discuss vulnerabilities in the context of business impact.The conversation highlights the importance of translating cybersecurity issues into business terms and emphasizes the need for consolidation and effective communication between different teams and tools. Dimitri shares how Brinqa is addressing this challenge by helping organizations tie their various cybersecurity tools together and better align their cybersecurity strategies with business objectives.During the RSA Conference, Dimitri expects to see growing interest in consolidating and managing security tools more effectively. He also anticipates an increasing number of professionals looking to change traditional vulnerability management approaches and better address the risks associated with different tools. If you are intrigued by the conversation, you can find Brinqa in the North Hall during the conference or book a meeting with the team to learn more.Note: This story contains promotional content. Learn more: https://www.itspmagazine.com/their-infosec-storyGuest:Dimitri Vlachos, CMO at Brinqa [@brinqa]On Linkedin | https://www.linkedin.com/in/dvlachos/On Twitter | https://twitter.com/DimitriVlachosResourcesLearn more about Brinqa and their offering: https://itspm.ag/brinqa-pmdpConnect with Brinqa during RSA Conference: https://itspm.ag/brinqa6gp5Hear more stories from Brinqa: www.itspmagazine.com/their-stories/see-all-of-your-security-findings-in-one-place-act-on-them-precisely-a-collection-of-brinqa-stories-from-rsa-conference-2023For more RSAC Conference Coverage podcast and video episodes visit: https://www.itspmagazine.com/rsa-conference-usa-2023-rsac-san-francisco-usa-cybersecurity-event-coverageAre you interested in telling your story?https://www.itspmagazine.com/telling-your-story
In this episode of Greece Chats Podcast with Tony Kariotis, I am joined by Marianthi Vlachos, founder of Hellenic Aesthetic. Marianthi Vlachos is a Greek-American jewelry designer, retail entrepreneur and founder of Hellenic Aesthetic, America's first store dedicated solely to Greek fashion. With it's e-shop launch in 2017 and the opening of its brick and mortar boutique in New York City in 2021, Hellenic Aesthetic is the premiere shopping platform for Greek brands in the USA and beyond. Marianthi not only hand selects each item available at Hellenic Aesthetic but also designs Hellenic Aesthetic's fine jewelry collection, leather goods and many other items. Her pieces evoke her nostalgia and love for all things Greek, from Greek key jewelry to vintage inspired tourist t-shirts. Most recently, Marianthi cofounded Rise With Apollo, a specialty coffee company where she serves as Creative Director. -- You can learn more about Marianthi and Hellenic Aesthetic at: https://www.hellenicaesthetic.com https://www.instagram.com/marianthiv -- Greece Chats Podcast with Tony Kariotis is brought to you by: https://www.greece-media.com https://www.greece-media.com/greecechats
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.20.533396v1?rss=1 Authors: Anil, S., Lu, H., Rotter, S., Vlachos, A. Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to induce neuronal plasticity in healthy individuals and patients. Designing effective and reproducible rTMS protocols poses a major challenge in the field as the underlying biomechanisms remain elusive. Current clinical protocol designs are often based on studies reporting rTMS-induced long-term potentiation or depression of synaptic transmission. Herein, we employed computational modeling to explore the effects of rTMS on long-term structural plasticity and changes in network connectivity. We simulated a recurrent neuronal network with homeostatic structural plasticity between excitatory neurons, and demonstrated that this mechanism was sensitive to specific parameters of the stimulation protocol (i.e., frequency, intensity, and duration of stimulation). The feedback-inhibition initiated by network stimulation influenced the net stimulation outcome and hindered the rTMS-induced homeostatic structural plasticity, highlighting the role of inhibitory networks. These findings suggest a novel mechanism for the lasting effects of rTMS, i.e., rTMS-induced homeostatic structural plasticity, and highlight the importance of network inhibition in careful protocol design, standardization, and optimization of stimulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.23.513396v1?rss=1 Authors: Kruse, P., Vlachos, A., Lenz, M. Abstract: Neurological diseases can lead to the denervation of brain regions caused by demyelination, traumatic injury or cell death. Nevertheless, the molecular and structural mechanisms underlying the lesion-induced reorganization of denervated brain regions are a matter of ongoing investigation. In order to address this issue, we performed an entorhinal cortex lesion (ECL) in organotypic entorhinal-hippocampal tissue cultures and studied denervation-induced homeostatic plasticity of mossy fiber synapses, which connect dentate granule cells with CA3 pyramidal neurons and play important roles in spatial learning. Partial denervation caused a homeostatic strengthening of excitatory neurotransmission in dentate granule cells (GC), in CA3 pyramidal neurons, and their direct synaptic connections as revealed by paired recordings (GC-to-CA3). These functional changes were accompanied by ultrastructural reorganization of mossy fiber synapses, which regularly contain the plasticity-related protein synaptopodin and the spine apparatus organelle. We demonstrate that the spine apparatus organelle and its associated protein synaptopodin assemble ribosomes in close proximity to synaptic sites and moreover we unravel synaptopodin-related transcriptome, which can be linked to the expression of homeostatic synaptic plasticity. Notably, synaptopodin-deficient tissue preparations that lack the spine apparatus organelle, failed to express homeostatic adjustments of both excitatory neurotransmission and the region-specific transcriptome. Hence, synaptopodin and the spine apparatus organelle form local protein synthesis hubs that are essential for mediating lesion-induced homeostatic synaptic plasticity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
I spoke to Anna Vlachos, a former TV Reporter in Toronto, Canada to hear her motherhood journey story. She conceived all 3 children naturally in her 40s! She didn't expect to get pregnant so easily, yet that is exactly what happened for her and she even conceived her last child while she was on birth control. ISABEL PROSPER @firsttimemomsbeyond35 ANNA VLACHOS @anna.vlachos.1 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/isabel-prosper/support
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.05.506635v1?rss=1 Authors: Lenz, M., Eichler, A., Kruse, P., Galanis, C., Kleidonas, D., Jedlicka, P., Müller, U., Deller, T., Vlachos, A. Abstract: The perforant path provides the main cortical excitatory input to the hippocampus. Due to its important role in information processing and coding, entorhinal projections to the dentate gyrus have been studied in considerable detail. Nevertheless, a characterization of synaptic transmission between individual connected pairs of entorhinal stellate cells and dentate granule cells is still pending. Here, we have used organotypic entorhino-hippocampal tissue cultures, in which the entorhino-dentate (EC-GC) projection is present and EC-GC pairs can be studied using whole-cell patch clamp recordings. Using cultures of wildtype mice, the properties of EC-GC synapses formed by afferents from the lateral and medial entorhinal cortex were compared and differences in short-term plasticity were revealed. Since the perforant path is severely affected in Alzheimer's disease, we used cultures of APP-deficient mice to address the role of the amyloid-precursor protein (APP) at this synapse. APP-deficiency caused alterations in excitatory neurotransmission at medial perforant path synapses that were accompanied by transcriptomic and ultrastructural changes. Moreover, the deletion of pre- but not postsynaptic APP through the local injection of Cre-expressing AAVs in conditional APPflox/flox tissue cultures increased the efficacy of neurotransmission at perforant path synapses. Together, these data suggest a physiological role for presynaptic APP at medial perforant path synapses, which may be adversely affected under conditions of altered APP processing. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Using brain-computer interface or electrodes implanted in the brain, German scientists have successfully enabled a fully paralysed ALS patient in a completely locked-in state with no voluntary muscle control, to communicate with full sentences. ThePrint's Sandhya Ramesh explains the technology and the ethical concerns it raises. Subscribe to the Pure Science Telegram Channel https://t.me/PureScienceWithSandhyaRamesh Supplementary reading: Chaudhary, U., Vlachos, I., Zimmermann, J.B. et al. Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training. Nat Commun 13, 1236 (2022). https://doi.org/10.1038/s41467-022-28859-8 With new ‘brain-reading' research, a once-tarnished scientist seeks redemption https://www.statnews.com/2022/03/22/niels-birbaumer-brain-computer-interface-research/
Wo eine Tür sich schließt, öffnet sich eine neue ... Habt ihr das auch schon erlebt? Es gibt Ereignisse im Leben, die uns ausbremsen, manchmal völlig aus der Bahn werfen, innehalten lassen. Häufig sind das im Rückblick die Momente, in denen wir einen neuen Weg einschlagen, Dinge radikal ändern. So ist es auch meinem heutigen Gast ergangen. Die ersten Jahre ihrer Karriere verbrachte meine Kollegin Vanessa in der Wirtschaftsprüfung, wo sie Jahresabschlüsse unserer Mandant:innen prüfte. Doch dann gab es eine entscheidende Zäsur, auf die ein radikaler Richtungswechsel folgte. Heute arbeitet sie noch immer bei EY, aber sie widmet sich ganz anderen Aufgaben. In dieser Folge spreche ich mit Vanessa über ihre Anfänge bei EY und ihre nächsten Schritte in der Wirtschaftsprüfung, zum Steuerberaterexamen und was danach kam. Sie erzählt ganz echt und ungeschminkt, wie sie erkannt hat, dass sie einen neuen Weg gehen wollte – und wohin sie dieser Weg inzwischen geführt hat. Viel Spaß beim Zuhören! Vernetze dich mit Vanessa: https://www.linkedin.com/in/vanessa-laura-vlachos-975585169/ Mehr über Karriereperspektiven in unserer Steuerberatung erfährst du hier: https://www.ey.com/de_de/careers/tax Weitere Infos zu EY als Arbeitgeber findest du hier: www.de.ey.com/karriere Folge uns auch auf unseren Social-Media-Kanälen, um immer up to date zu bleiben und die neueste Podcast-Folge nicht zu verpassen: Instagram @ey_germany Facebook @EYCareersDeutschland
Cena Vlachos, my mom joins me for the inaugural Monthly Mom chat. We talk about her lifestyle transformation and movies we enjoyed as a kid, and her terrible experience of seeing The Exorcist in theaters, as an 11 year old. Future Monthly Mom chats will be apart of the new Dan Cable Presents Patreon. The links for the sponsors of this episode of the podcast, as well as the Patreon are below!Thank you to DistroKid for sponsoring this episode of the podcast. Use the link below to receive 30% off your first year of DistroKid services. https://distrokid.com/?c=cable www.producerowcafe.com www.north45bar.com INSTAGRAM: @north45bar@producerowcafe @dancablepresents @distrokid @vrtxmag Email: dancablepresents@gmail.com Spotify Playlists: https://open.spotify.com/user/54u8tkp1mevtd0i3cz79qbp8l?si=-4NT4PWPSlSowoXQkJhlkA Venmo: Dan-Cable-PresentsPatreon:https://www.patreon.com/dancablepresents
Today I'm joined by a fellow spiritual podcaster, who was also an elite athlete before stepping into her role as a spiritual coach. Her experience playing sport for 15 years has influenced her spirituality and her mindset in all sorts of amazing ways and I can't wait to hear her words of wisdom about it. She is also a gifted healer and highly intuitive. She listens to her own guidance and intuition when creating her content, knowing that what needs to be created will be created and it will reach whoever needs to hear it. Which is such a beautiful way to create! Please join me in welcoming Kaye from the Soul 2 Soul Podcast! ⚽ FIND KAYE'S PODCAST: https://soul2soulwellness.com.au/ ⚽ FOLLOW KAYE: @kayevlachos_soul2soulwellness
Henry Chisholm runs through all of the news surrounding Colorado's coaching change.
Some weeks ago we met for the first podcast and talk about the plans for the olympic games this year. Now the games are over and greece made it to the gold medal match. Hear what happends during the tournament within the team and why they missed to win the last game against Serbia. Head Coach Theodoros Vlachos of Greece will give us some insides und behinds the scenes information.
Joshua chats and performs with Alexandra Vlachos (Matilda), Winter Donnelly (Frozen the Musical), and Jaiden Klein (Frozen the Musical), and Joshua plays Freeze Your Brain from the musical Heathers. Learn more about your ad choices. Visit megaphone.fm/adchoices
Thank you to DistroKid for sponsoring this episode of the podcast. Use the link below to receive 30% off your first year of DistroKid services. https://distrokid.com/?c=cable Cena Vlachos is my Mom. I chatted with her about parental support, mental health, gratitude, and more! On this Mother’s Day Special. To keep up with the podcast, please check out the links below. INSTAGRAM: @dancablepresents @cenasmidt6 @producerowcafe @distrokid @vrtxmag @jungletelevision DCP SHIRTS https://www.dancablepresents.com/store DCP MUGS https://dan-cable-presents.myshopify.com/products/dcp-extra-buttered-5yr-anniversary-mug Spotify Playlists: https://open.spotify.com/user/54u8tkp1mevtd0i3cz79qbp8l?si=-4NT4PWPSlSowoXQkJhlkA TED TALK LINK https://www.youtube.com/watch?v=EvGkSEuWtaI
Perspectives on the Pandemic | "The Illusion of Evidence Based Medicine" Leemon McHenry 10 mins Leemon McHenry is Emeritus Professor in the Department of Philosophy , California State University, Northridge. Leemon does research in Philosophy of Science, Metaphysics and Bioethics. His current project is 'Evidence Based Medicine'. Vitamin A for nerve cells University Medical Center Freiburg (Germany), April 1, 2021 Neuroscientists agree that a person's brain is constantly changing, rewiring itself and adapting to environmental stimuli. This is how humans learn new things and create memories. This adaptability and malleability is called plasticity. "Physicians have long suspected that remodeling processes also take place in humans at the contact points between nerve cells, i.e. directly at the synapses. Until now, however, such a coordinated adaptation of structure and function could only be demonstrated in animal experiments," says Prof. Dr. Andreas Vlachos from the Institute of Anatomy and Cell Biology at the University of Freiburg. But now Vlachos, together with Prof. Dr. Jürgen Beck, head of the Department of Neurosurgery at the University Medical Center Freiburg, has provided experimental evidence for synaptic plasticity in humans. In addition to Vlachos and Beck, the research team consists of Dr. Maximilian Lenz, Pia Kruse and Amelie Eichler from the University of Freiburg, Dr. Jakob Strähle from the University Medical Center Freiburg and colleagues from Goethe University Frankfurt. The results were presented in the scientific journal eLife. In the experiments, the team investigated whether so-called dendritic spines change when exposed to a vitamin A derivative called retionic acid. Dendritic spines are the parts of the synapse that receive, process and transmit signals during communication between neurons. As such, they play a crucial role in brain plasticity and are constantly adapting to everyday experience. For example, learning can change the number and shape of dendritic spines. However, a transformation in the number or shape of the spines is also found in diseases such as depression or dementia. The research shows that retinoic acid not only increases the size of dendritic spines, but also strengthens their ability to transmit signals between neurons. "We have concluded from our results that retinoic acids are important messengers for synaptic plasticity in the human brain. Thus, this finding contributes to the identification of key mechanisms of synaptic plasticity in the human brain and could support the development of new therapeutic strategies for brain diseases, such as depression," says Vlachos. To experimentally demonstrate that synaptic plasticity also exists in humans, the researchers use tiny samples of human cerebral cortex, which must be compulsorily removed during neurosurgical procedures for therapeutic reasons. The removed brain tissue was then treated with retinoic acid before functional and structural properties of neurons were analyzed using electrophysiological and microscopic techniques. Study: Chemical compound in certain essential oils promotes wound healing Indiana University, April, 2021 A study from Indiana University revealed that a chemical compound in essential oils may enhance wound healing, especially when applied topically. According to co-author Sachiko Koyama, essential oils – like those from lavender, rosemary, ylang-ylang and black pepper – contain a chemical compoundcalled beta-caryophyllene. This contributes to improved wound healing, based on a murine model. “This is the first finding at the chemical-compound level showing improved wound healing in addition to changes in gene expression in the skin,” said Koyama. Beta-caryophyllene may decrease inflammation and accelerate re-epithelialization. The latter refers to the restoration of structure and function of injured tissues. During this process, epithelial cells at the wound start to migrate and cover the injured area. The researchers added that beta-caryophyllene may prevent cell death, allowing cells to survive and proliferate. “I thought maybe wound healing would be accelerated if inflammation was suppressed, stimulating an earlier switch from the inflammatory stage to the next stage,” she added. The team also noted increased gene expression of hair follicle stem cells in the treated tissue. This potentially indicate that there’s more to wound-healing activity of beta-caryophyllene than just activating genes. “It’s possibly more complicated,” she added. “Our findings suggest the involvements of some other routes in addition to CB2. I hope to clarify the mechanisms of action in the near future.” Koyama, a social neuroscientist at Indiana University, said that she wasn’t interested in studying essential oils at first, as her field of expertise was in pheromone and social status. However, her interest was sparked when she saw students working on the wound healing process in mice. She knew from experience that beta-caryophyllene can also activate cannabinoid receptor 2 (CB2), which has anti-inflammatory and analgesic properties. Healing beyond smell Most people know essential oils by way of aromatherapy. These are often used with diffusers, aromatic spritzers, inhalers, facial steamers and clay masks to bring out the aroma coming from the oil. Essential oils, in particular, may help with asthma, insomnia, fatigue and depression, among others. In the study, the researchers did not find any relationship between the sense of smell and the healing properties of beta-caryophyllene. (Related: Curcumin found to aid in the healing of skin wounds.) Koyama also offered a caveat for those looking to use essential oils for treatment, in particular, warning against the use of any essential oils. In the study, the researchers used essential oils that underwent purification processes to achieve that result. “It’s not very precise to use the essential oils themselves because there are differences,” she added. “Even if you say you used lavender, when the lavender was harvested, where it was harvested, how it was stored—all of this makes a difference in the chemical composition.” The team is also hopeful that their results will warrant further studies to determine an exact chemical composition for beta-caryophyllene that can be used to treat skin wounds. “There are many things to test before we can start using it clinically, but our results are very promising and exciting; someday in the near future, we may be able to develop a drug and drug delivery methods using the chemical compounds found in essential oils,” she added. Exercise may help slow cognitive decline in some people with Parkinson's disease Hallym University (South Korea), April 1, 2021 For people with Parkinson's disease, problems with thinking and memory skills are among the most common nonmotor symptoms of the disease. A new study shows that exercise may help slow cognitive decline for some people with the disease. The study is published in the March 31, 2021, online issue of Neurology. Research has suggested that people with Parkinson's who have the gene variant apolipoprotein E e4, or APOE e4, may experience faster cognitive decline and earlier in the disease than people without the variant. APOE e4 is known as a genetic risk factor for Alzheimer's disease. The study looked at whether exercise could play a role in slowing cognitive decline for people with APOE e4. "Problems with thinking skills and memory can have a negative impact on people's quality of life and ability to function, so it's exciting that increasing physical activitycould have the potential to delay or prevent cognitive decline," said study author Jin-Sun Jun, M.D., of Hallym University in Seoul, Korea. The study involved 173 people with early Parkinson's disease who were on average 63 years old at the time and 59 years old when they developed the disease. A total of 27% had the APOE e4 gene variant. People reported their physical activity with a questionnaire on how much activity they had in the previous week through leisure activities such as walking or biking, household activities such as dusting or yard work and work activities for pay or as a volunteer. People took a test of their thinking skills at the beginning of the study and then one and two years later. Overall, scores at the beginning of the study averaged 26 points. For people with the APOE e4 gene variant, test scores declined by an average of 1.33 points by the end of the study compared to those without the variant. But researchers also found that greater physical activity at the start of the study lessened APOE e4-related cognitive decline two years later by an average of 0.007 points. "Additional research is needed to confirm our findings, but these results would support the use of interventions that target physical activity as a way to delay cognitive decline in people with early Parkinson's who have the APOE e4 gene variant," Jun said. A limitation of the study was that participants reported their own levels of physical activity, so there is the possibility that they would not remember their levels exactly. Time to shift from 'food security' to 'nutrition security' to increase health and well-being Tufts and Georgetown Universities, April 1, 2021 In the 1960s, a national focus on hunger was essential to address major problems of undernutrition after World War II. In the 1990s, the nation shifted away from hunger toward "food insecurity" to better capture and address the challenges of food access and affordability. Now, a new Viewpoint article argues that today's health and equity challenges call for the U.S. to shift from "food insecurity" to "nutrition insecurity" in order to catalyze appropriate focus and policies on access not just to food but to healthy, nourishing food. The Viewpoint, by Dariush Mozaffarian of the Friedman School of Nutrition Science & Policy at Tufts University, Sheila Fleischhacker of Georgetown Law School, and José Andrés of World Central Kitchen, was published online in JAMA this week. The concept of food security focuses on access to and affordability of food that is safe, nutritious, and consistent with personal preferences. In reality, however, the "nutritious" part often has been overlooked or lost in national policies and solutions, with resulting emphasis on quantity, rather than quality, of food, say the authors. "Food is essential both for life and human dignity. Every day, I see hunger, but the hunger I see is not only for calories but for nourishing meals. With a new focus on nutrition security, we embrace a solution that nourishes people, instead of filling them with food but leaving them hungry," said Chef José Andrés, founder of World Central Kitchen. The authors define nutrition security as having consistent access to and availability and affordability of foods and beverages that promote well-being, while preventing -- and, if needed, treating -- disease. Nutrition security provides a more inclusive view that recognizes that foods must nourish all people. "'Nutrition security' incorporates all the aims of food security but with additional emphasis on the need for wholesome, healthful foods and drinks for all. COVID-19 has made clear that Americans who are most likely to be hungry are also at highest risk of diet-related diseases including obesity, diabetes, heart disease, and many cancers - a harsh legacy of inequities and structural racism in our nation. A new focus on nutrition security for all Americans will help crystallize and catalyze real solutions that provide not only food but also well-being for everyone," said first author Dariush Mozaffarian, dean of the Friedman School of Nutrition Science & Policy at Tufts University. "It's the right time for this evolution," said Sheila Fleischhacker, adjunct professor at Georgetown Law School, who has drafted food, nutrition and health legislation and campaign positions at the local, state, tribal and federal levels. "By prioritizing nutrition security, we bring together historically siloed areas - hunger and nutrition - which must be tackled together to effectively address our modern challenges of diet-related diseases and disparities in clinical care, government food and food assistance policies, public health investments, and national research." "The current approach is not sufficient," the authors write, and "traditionally marginalized minority groups as well as people living in rural and lower-income counties are most likely to experience disparities in nutrition quality, food insecurity, and corresponding diet-related diseases." Fasting acts as diet catalyst in those with metabolic syndrome Max Delbruck Center for Molecular Medicine (Germany), March 30, 2021 One in four Germans suffers from metabolic syndrome. Several of four diseases of affluence occur at the same time in this 'deadly quartet': obesity, high blood pressure, lipid metabolism disorder and diabetes mellitus. Each of these is a risk factor for severe cardiovascular conditions, such as heart attack and stroke. Treatment aims to help patients lose weight and normalise their lipid and carbohydrate metabolism and blood pressure. In addition to exercise, doctors prescribe a low-calorie and healthy diet. Medication is often also required. However, it is not fully clear what effects nutrition has on the microbiome, immune system and health. A research group led by Dr Sofia Forslund and Professor Dominik N. Müller from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Experimental and Clinical Research Center (ECRC) has now examined the effect a change of diet has on people with metabolic syndrome. The ECRC is jointly run by the MDC and Charité Universitätsmedizin Berlin. "Switching to a healthy diet has a positive effect on blood pressure," says Andras Maifeld, summarising the results. "If the diet is preceded by a fast, this effect is intensified." Maifeld is the first author of the paper, which was recently published in the journal "Nature Communications". Broccoli over roast beef Dr Andreas Michalsen, Senior Consultant of the Naturopathy Department at Immanuel Hospital Berlin and Endowed Chair of Clinical Naturopathy at the Institute for Social Medicine, Epidemiology and Health Economics at Charité - Universitätsmedizin Berlin, and Professor Gustav J. Dobos, Chair of Naturopathy and Integrative Medicine at the University of Duisburg-Essen, recruited 71 volunteers with metabolic syndrome and raised systolic blood pressure. The researchers divided them into two groups at random. Both groups followed the DASH (Dietary Approach to Stop Hypertension) diet for three months, which is designed to combat high blood pressure. This Mediterranean-style diet includes lots of fruit and vegetables, wholemeal products, nuts and pulses, fish and lean white meat. One of the two groups did not consume any solid food at all for five days before starting the DASH diet. On the basis of immunophenotyping, the scientists observed how the immune cells of the volunteers changed when they altered their diet. "The innate immune system remains stable during the fast, whereas the adaptive immune system shuts down," explains Maifeld. During this process, the number of proinflammatory T cells drops, while regulatory T cells multiply. A Mediterranean diet is good, but to also fast is better The researchers used stool samples to examine the effects of the fast on the gut microbiome. Gut bacteria work in close contact with the immune system. Some strains of bacteria metabolise dietary fibre into anti-inflammatory short-chain fatty acids that benefit the immune system. The composition of the gut bacteria ecosystem changes drastically during fasting. Health-promoting bacteria that help to reduce blood pressure multiply. Some of these changes remain even after resumption of food intake. The following is particularly noteworthy: "Body mass index, blood pressure and the need for antihypertensive medication remained lower in the long term among volunteers who started the healthy diet with a five-day fast," explains Dominik Müller. Blood pressure normally shoots back up again when even one antihypertensive tablet is forgotten. Blood pressure remains lower in the long term - even three months after fasting Together with scientists from the Helmholtz Centre for Infection Research and McGill University, Montreal, Canada, Forslund's working group conducted a statistical evaluation of these results using artificial intelligence to ensure that this positive effect was actually attributable to the fast and not to the medication that the volunteers were taking. They used methods from a previous study in which they had examined the influence of antihypertensive medication on the microbiome. "We were able to isolate the influence of the medication and observe that whether someone responds well to a change of diet or not depends on the individual immune response and the gut microbiome," says Forslund. If a high-fibre, low-fat diet fails to deliver results, it is possible that there are insufficient gut bacteria in the gut microbiome that metabolise fibre into protective fatty acids. "Those who have this problem often feel that it is not worth the effort and go back to their old habits," explains the scientist. It is therefore a good idea to combine a diet with a fast. "Fasting acts as a catalyst for protective microorganisms in the gut. Health clearly improves very quickly and patients can cut back on their medication or even often stop taking tablets altogether." This could motivate them to stick to a healthy lifestyle in the long term. Rice bran adds microbiome diversity, slows growth of colon cancer cells University of Colorado, April 5, 2021 At the American Association for Cancer Research (AACR) Annual Meeting, University of Colorado Cancer Center researchers at Colorado State University present results of a phase II clinical trial of 29 people exploring the effects of adding rice bran or navy beans to the diets of colorectal cancer survivors. After the 4-week randomized-controlled trial during which people added rice bran, navy bean powder or neither, both the rice bran and navy bean groups showed increased dietary fiber, iron, zinc, thiamin, niacin, vitamin B6, folate, and alpha-tocopherol. The rice bran group also showed increased microbiome richness and diversity. When researchers treated colorectal cancer cells with stool extracts from these groups, they saw reduced cell growth from the groups that had increased rice bran and navy bean consumption. Previous work shows the ability of these diets to decrease colorectal cancer risk in animal models. The current trial confirms that people can eat enough bean- and rice bran-enhanced foods to promote gut health at levels shown to prevent colorectal cancer in animals. Guidelines from the American Institute for Cancer Research recommend reducing the risk of cancer by eating more vegetables, fruits, whole grains and legumes, such as beans. Ryan has established from these studies that eating a half-cup of beans and 30 grams of rice bran per day is enough to see changes in small molecules that can confer protection against colorectal cancer. "The simple message is, 'Food is medicine,' and we are looking at how to simplify that and make it apply to our everyday lives," says study co-author Regina Brown, MD, assistant professor at the CU School of Medicine and oncologist for CUHealth. Brown is long-time collaborator of CU Cancer Center investigator and CSU assistant professor, Elizabeth Ryan, PhD. The Ryan Lab in the CSU College of Veterinary Medicine and Biomedical Sciences studies the potential power of navy beans and rice bran to promote digestive health and to prevent metabolic alterations in obesity, heart disease and certain cancers. "The evidence is there in animals and we can now study this in people. The question is, what are we doing to achieve adequate levels of intake of these foods?" Ryan said. "It's not enough to say 'I eat them once in a while.' That's not going to work, particularly if you are at higher risk. You have to meet a dose, just like you need a dose of a certain drug, you need to reach intake levels and consume increased amounts of these foods, and that's where people, including me, are challenged. Not everyone wants to open up a can of beans and eat them every day." The two met about 10 years ago, when Ryan was a researcher in CSU professor Henry Thompson's Cancer Prevention Lab, and Brown was practicing medicine in Fort Collins and caring for her mother, who had uterine cancer. "It was kind of a novel partnership and had we not dug in our heels it could have died, but I told Elizabeth, 'Your work is so interesting and so valuable. We have to take this translational research from the benchtop to the clinic.' I guarantee, nine out of 10 of my patients, the first thing they ask is about their diet," Brown said. The study's lead author is Erica Borresen, Ryan's research associate and study coordinator, who worked with colorectal cancer survivors to make sure they ate their beans and rice bran provided in meals and snacks, and that they filled out their food logs and gastrointestinal health questionnaires. It was sometimes intimate and awkward, but so is getting a colonoscopy and being treated for colorectal cancer. "Our participants donated their time and effort, and I want to make sure they understand they are appreciated," said Borresen, who earned her Master of Public Health at the Colorado School of Public Health, and plans to become a physician's assistant. "I came to realize I love the patient interaction - that's one of my favorite parts about coordinating our studies." The next phase of Ryan's research examines effects of the cooked navy bean powder and rice bran on the colon tissue of people who have already had colorectal cancer and are at high risk for recurrence. "I really feel that there's hope in this being a practical solution to improve gut health and specifically colorectal cancer prevention," says Ryan. Research suggests L-tryptophan supplements might help prevent impulsivity associated with psychological disorders University of California Berkeley, April 2, 2021 According to news reporting originating from Berkeley, California, research stated, “Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system.” Our news editors obtained a quote from the research from the University of California Berkeley, “Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r = -.502, p< .010, and (lack-of) Follow-Through scores, r = -.407, p< .050. Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits.” According to the news editors, the research concluded: “It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.” This research has been peer-reviewed. Nutritional supplementation in preconception and pregnancy linked to reduced risk of preterm birth University of Southampton (UK), March 30, 2021 Increasing evidence suggests that a mother's nutritional status at the onset of pregnancy has an important influence on the growth and development of her baby, and that a good nutritional status during pregnancy may help reduce the risk of pregnancy complications. A specific blend of nutrients and probiotics was tested in an international multicentre double blind randomized controlled trial NiPPeR (Nutritional Intervention Preconception and during Pregnancy to maintain healthy glucosE levels and offspRing health). Researchers from the international EpiGen Global Research Consortium, an academic group of clinicians and scientists including from around the world, including the University of Southampton, specifically assessed the effects of a nutritional intervention, a combination of myo-inositol, probiotics and micronutrients, consumed both before and during pregnancy, on maintaining healthy blood sugar levels in pregnancy and sustaining a healthy pregnancy and delivery. As published in the journal Diabetes Care, (Myo-inositol, Probiotics and Micronutrient Supplementation from Preconception for Glycemia in Pregnancy: the NiPPeR study involved 1,729 women from the UK, New Zealand and Singapore who were planning pregnancy—one of the largest international preconception randomized controlled trials of its type. While the study found that the intervention did not influence the mother's blood sugar levels or birthweights of the 585 babies born, the nutritional supplement decreased the incidence of preterm birth, particularly the cases associated with preterm pre-labor rupture of membranes. "Preterm delivery is a serious, common and costly public health problem worldwide that continues to increase in incidence," said Professor Keith Godfrey from the MRC Lifecourse Epidemiology Unit at the University of Southampton. "Preterm pre-labor rupture of membranes is a major cause of preterm birth. Our study presents for the first time a clinical trial of a novel non-pharmacological approach that started preconception and extended throughout pregnancy, through the innovative use of a combination of nutritional ingredients. The study findings highlight the potential value of the mix of nutrients and probiotics in reducing the risk of preterm birth and supporting a timely delivery," Professor Godfrey continued. Associate Professor Shiao-Yng Chan, a principal investigator on the study from the Yong Loo Lin School of Medicine, National University of Singapore, deputy executive director at the Singapore Institute for Clinical Sciences, A*STAR, and Senior Consultant, Department of Obstetrics & Gynaecology, National University Hospital, commented "One of the strengths of our study is the diversity of its participants as we have involved women of multiple ethnicities from the general population across three countries, which means that the outcomes have wide relevance to women planning for pregnancy. Additionally, the study included blinded intervention and control groups, so bias is minimized." Sharing his thoughts, Professor Wayne Cutfield, principal investigator on the study from the University of Auckland, New Zealand, said, "The importance of the preconception period on maternal and offspring health is being increasingly recognized, but there are very few randomized control trials seeking to optimize preconception nutrition." Dr. Isabelle Bureau-Franz, Head of Nestlé Research, who partnered with EpiGen for this academic-led trial, says, "We are focused on discovering science-based solutions for mothers and their infants during preconception, pregnancy and while breastfeeding. The NiPPeR study is a great example of how a public-private partnership can build scientific evidence on nutritional interventions in a largely understudied group."
For most of the coaches it is enough to train one team, but there are also other successful examples that there are other solutions. Theodoros Vlachos is one of these good examples because he is at the same time head coach of two big teams. Olympiacos Piraeus and the Greek National Team. Theodoros give us some insights of his coaching routine with both teams, what are the differences to other countries and what makes them successful in the younger teams. This is the first part of the talk with Theodoros and the next Episode next week will cover the second part of our conversation.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.16.336065v1?rss=1 Authors: Lenz, M., Eichler, A., Kruse, P., Strehl, A., Rodriguez-Rozada, S., Goren, I., Yogev, N., Frank, S., Waisman, A., Deller, T., Jung, S., Maggio, N., Vlachos, A. Abstract: Systemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by LPS-induced inflammation. Specifically, we explored brain tissue cultures to learn more about the direct effects of LPS on neural tissue, and we tested for the plasticity-restoring effects of the anti-inflammatory cytokine interleukin 10 (IL10). As shown previously, 10 Hz repetitive magnetic stimulation (rMS) of organotypic entorhino-hippocampal tissue cultures induced a robust increase in excitatory neurotransmission onto CA1 pyramidal neurons. Furthermore, LPS-treated tissue cultures did not express rMS-induced synaptic plasticity. Live-cell microscopy in tissue cultures prepared from a novel transgenic reporter mouse line [C57BL6-Tg(TNFa-eGFP)] confirms that ex vivo LPS administration triggers microglial tumor necrosis factor alpha (TNF) expression, which is ameliorated in the presence of IL10. Consistent with this observation, IL10 hampers the LPS-induced increase in TNF, IL6, IL1{beta}, and IFN{gamma} and restores the ability of neurons to express rMS-induced synaptic plasticity in the presence of LPS. These findings establish organotypic tissue cultures as a suitable model for studying inflammation-induced alterations in synaptic plasticity, thus providing a biological basis for the diagnostic use of transcranial magnetic stimulation in the context of brain inflammation. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.316190v1?rss=1 Authors: Turi, Z., Lenz, M., Paulus, W., Mittner, M., Vlachos, A. Abstract: Background: Repetitive transcranial magnetic stimulation (rTMS) is an increasingly used, non-invasive brain stimulation technique in neuroscience research and clinical practice with a broad spectrum of suggested applications. Among other parameters, the choice of stimulus intensity and intracranial electric field strength substantially impact rTMS outcome. This review provides a systematic overview of the intensity selection approaches and stimulation intensities used in human rTMS studies. We also examined whether studies report sufficient information to reproduce stimulus intensities in basic science research models. Methods: We performed a systematic review by focusing on original studies published between 1991 and 2020. We included conventional (e.g., 1 Hz or 10 Hz) and patterned protocols (e.g., continuous or intermittent theta burst stimulation). We identified 3,784 articles in total, and we manually processed a representative portion (20%) of randomly selected articles. Results: The majority of the analyzed studies (90% of entries) used the motor threshold (MT) approach and stimulation intensities from 80 to 120% of the MT. For continuous and intermittent theta burst stimulation, the most frequent stimulation intensity was 80% of the active MT. Most studies (92% of entries) did not report sufficient information to reproduce the stimulation intensity. Only a minority of studies (1.03% of entries) estimated the rTMS-induced electric field strengths. Conclusion: We formulate easy-to-follow recommendations to help scientists and clinicians report relevant information on stimulation intensity. Future standardized reporting guidelines may facilitate the use of basic science approaches aiming at better understanding the molecular, cellular, and neuronal mechanisms of rTMS. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.23.310219v1?rss=1 Authors: Shirinpour, S., Hananeia, N., Rosado, J., Galanis, C., Vlachos, A., Jedlicka, P., Queisser, G., Opitz, A. Abstract: Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique widely used in research and clinical applications. However, its mechanism of action and the neural response to TMS are still poorly understood. Multi-scale modeling can complement experimental research and provide a framework between the physical input parameters and the subcellular neural effects of TMS. At the macroscopic level, sophisticated numerical models exist to estimate the induced electric fields in whole-brain volume conductor models. However, multi-scale computational modeling approaches to predict TMS cellular and subcellular responses, crucial to understanding TMS plasticity inducing protocols, are not available so far. Here, we develop a multi-scale Neuron Modeling for TMS toolbox (NeMo-TMS) that enables researchers to easily generate accurate neuron models from morphological reconstructions, couple them to the external electric fields induced by TMS, and to simulate the cellular and subcellular responses of the neurons. Both single-pulse and rTMS protocols can be simulated and results visualized in 3D. We openly share our toolbox and provide example scripts and datasets for the user to explore. NeMo-TMS toolbox (https://github.com/OpitzLab/NeMo-TMS) allows researchers a previously not available level of detail and precision in realistically modeling the physical and physiological effects of TMS. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.267104v1?rss=1 Authors: Lenz, M., Kruse, P., Eichler, A., Muellerleile, J., Straehle, J., Jedlicka, P., Beck, J., Deller, T., Vlachos, A. Abstract: A defining feature of the brain is its ability to adapt structural and functional properties of synaptic contacts in an experience-dependent manner. In the human cortex direct experimental evidence for synaptic plasticity is currently missing. Here, we probed plasticity in human cortical slices using the vitamin A derivative all-trans retinoic acid, which has been suggested as medication for the treatment of neuropsychiatric disorders, e.g., Alzheimer's disease. Our experiments demonstrate coordinated structural and functional changes of excitatory synapses of superficial (layer 2/3) pyramidal neurons in the presence of all-trans retinoic acid. This synaptic adaptation is accompanied by ultrastructural remodeling of the calcium-storing spine apparatus organelle and requires mRNA-translation. We conclude that all-trans retinoic acid is a potent mediator of synaptic plasticity in the adult human cortex. Copy rights belong to original authors. Visit the link for more info
This week the buds chat with Cena Vlachos, Dan's Mom. Cena shares stories about her religious upbringing, family stories, and mental health and its alignment with spirituality. Email the show:biblebudspdx@gmail.comIG@biblebuds@ajackharrison@dancablepresents @cenasmidt6
It's the one you've been waiting for... The King of Survivor, Tony Vlachos. What does Jeff Probst think of Tony? What happened when cameras started falling out of the spy nest? Does Tony consider himself the King of Survivor? Hear those answers and much more as Tony Vlachos, from the back of a dark SUV, breaks down all the key moments of his winning game in Survivor 40, Winners at War, in this interview with Jonny Fairplay, Matt Bischoff, and Zack Hacker. You can purchase you Sunday Schooled Cancer t-shirt (available in 8 different options at jonnyfairplay.com (http://jonnyfairplay.com/) ALL PROFITS FROM THE SALE OF THIS SHIRT GO TO SUNDAY BURQUEST FROM SURVIVOR MILLENNIALS VS GEN X AND HER FIGHT AGAINST CANCER Check out our newest sponsor Magic Spoon Cereal. The cereal you've been waiting for; it’s keto-friendly, gluten-free, grain-free, soy-free, low carb, and GMO-free. Available in 4 tasty flavors: Cocoa, Fruity, Frosted, and Blueberry. And Magic Spoon is so confident in their product, it’s backed with a 100% happiness guarantee — so if you don’t like it for any reason, they'll refund your money, no questions asked. Go to http://magicspoon.com/SURVIVOR to grab a variety pack and try it today! And be sure to use our promo code SURVIVOR at checkout to get free shipping. And to give your immunity idol a boost, check out our sponsor bluechew.com (http://bluechew.com/) and use promo code: SURVIVOR to try it for free just pay the $5 shipping. And when they're down there make sure you use Manscaped, who is the best in men’s below the belt grooming. Manscaped offers precision engineered tools for your family jewels. Go to manscaped.com (http://manscaped.com/) and use promo code: SURVIVOR for 20% off and FREE shipping. Any fool can climb a wall or crawl through sand, but as every fan knows, Survivor challenges are won or lost at the puzzle. The most successful players are puzzle masters and you can be one, too. Perplexor's Puzzles creates hand-made, miniature replicas of many of Survivor's greatest and most challenging puzzles. Find out if you have what it takes by visiting the Perplexor's Puzzle store on Etsy or simply visiting survivorpuzzle.com (http://survivorpuzzle.com/) Enter promo code FAIRPLAY at checkout for a 10% discount. And become a patron at Patreon.com/SurvivorNSFW (http://patreon.com/SurvivorNSFW) to listen to member exclusive content like the weekly Q&A and our Top 10 lists, also become a member of the SECRET Survivor NSFW Facebook group and get cool stuff like posters, autographed pics, buffs and more!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.22.152066v1?rss=1 Authors: Galanis, C., Fellenz, M., Becker, D., Bold, C., Lichtenthaler, S. F., Mueller, U. C., Deller, T., Vlachos, A. Abstract: The physiological role of the amyloid-precursor protein (APP) is insufficiently understood. Recent work has implicated APP in the regulation of synaptic plasticity. Substantial evidence exists for a role of APP and its secreted ectodomain APPs in Hebbian plasticity. Here, we addressed the relevance of APP in homeostatic synaptic plasticity using organotypic tissue cultures of APP-/- mice. In the absence of APP, dentate granule cells failed to strengthen their excitatory synapses homeostatically. Homeostatic plasticity is rescued by amyloid-{beta} (A{beta} and not by APPs, and it is neither observed in APP+/+ tissue treated with {beta}- or {gamma}-secretase inhibitors nor in synaptopodin-deficient cultures lacking the Ca2+-dependent molecular machinery of the spine apparatus. Together, these results suggest a role of APP processing via the amyloidogenic pathway in homeostatic synaptic plasticity, representing a function of relevance for brain physiology as well as for brain states associated with increased A{beta} levels. Copy rights belong to original authors. Visit the link for more info
In the eighth of our Survivor: Winners at War post game deep dives, Rob Cesternino sits down with the winner of Survivor: Cagayan and Survivor: Winners at War Tony Vlachos to talk through his 39 day journey to become the second two time champion! The post Survivor 40 DEEP DIVE | Tony Vlachos appeared first on RobHasAwebsite.com.
Rob Has a Podcast | Survivor / Big Brother / Amazing Race - RHAP
In the eighth of our Survivor: Winners at War post game deep dives, Rob Cesternino sits down with the winner of Survivor: Cagayan and Survivor: Winners at War Tony Vlachos to talk through his 39 day journey to become the second two time champion! The post Survivor 40 DEEP DIVE | Tony Vlachos appeared first on RobHasAwebsite.com.
Rob Has a Podcast | Survivor / Big Brother / Amazing Race - RHAP
In the eighth of our Survivor: Winners at War post game deep dives, Rob Cesternino sits down with the winner of Survivor: Cagayan and Survivor: Winners at War Tony Vlachos to talk through his 39 day journey to become the second two time champion! The post Survivor 40 DEEP DIVE | Tony Vlachos appeared first on RobHasAwebsite.com.
Rob Has a Podcast | Survivor / Big Brother / Amazing Race - RHAP
In the eighth of our Survivor: Winners at War post game deep dives, Rob Cesternino sits down with the winner of Survivor: Cagayan and Survivor: Winners at War Tony Vlachos to talk through his 39 day journey to become the second two time champion!
In the eighth of our Survivor: Winners at War post game deep dives, Rob Cesternino sits down with the winner of Survivor: Cagayan and Survivor: Winners at War Tony Vlachos to talk through his 39 day journey to become the second two time champion! The post Survivor 40 DEEP DIVE | Tony Vlachos appeared first on RobHasAwebsite.com.
Psych! Bet you thought this episode wasn't ever coming. We have been marinating this episode for one month. Tender and juicy for your enjoyment - your favorite tribal talkers dish on the final episode of the penultimate season of Survivor. Hope you're hungry! --- Support this podcast: https://anchor.fm/tribaltalkpod/support
I denna episod får vi lära oss hur Stefan Vlachos byggt upp och leder Innovationsplatsen på Karolinska Universitetssjukhuset. Vi pratar om deras modell och hur man stödjer innovationsarbetet på sjukhuset, innovationsledning och utmaningarna och möjligheterna kopplade till det. Observera att denna episod spelades in precis innan Corona-epidemien om någon till äventyrs undrar över varför vi…Read more →
Sam and Charlie are back to cover the finale of Survivor Season 40: Winners at War. In their first ever podcast about something non-sports, they crown Tony Vlachos the GOAT of survivor, talk through what happened in the finale, the twists of Fire Tokens and Edge of Extinction, what they would want to see in future seasons, and much more. Theme Song: Royalty Free Music | Victory - Hip Hop Beat | No Copyright Instrumental --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
Recorded May 15, 2020 Follow us on social media Instagram: @dj9one @therealmattlorr @outtahctrl Twitter: @DJ_9one @therealmattlorr @outtahctrl
Recorded May 15, 2020 Follow us on social media Instagram: @dj9one @therealmattlorr @outtahctrl Twitter: @DJ_9one @therealmattlorr @outtahctrl
Diplomacy and the diplomatic life can place enormous stress on our relationships, and yet we don't tend to talk about what can happen when those relationships end. Why is that? My friend Katia Vlachos and I discuss breakups, separations and divorce in this episode. Katia has written some outstanding articles on the topic within the global expatriate community and shares some amazing insights with us here. About Katia Katia's professional background is in policy analysis. She holds an MA from the Kennedy School of Government at Harvard and a PhD from the RAND Corporation. Katia is a seasoned expat herself, having lived in eight cities, seven countries and three continents in the past 20 years. She currently lives in Zurich, Switzerland. Her book ‘A Great Move: Surviving and Thriving In Your Expat Assignment' is an indispensable resource for anyone who moves internationally. Her website is www.katiavlachos.com and her book can be ordered from www.katiavlachos.com/book Links Website: www.thelonelydiplomat.com Blog post: ‘The Lonely Diplomat: on breaking up' at https://bit.ly/3frlGRH My book: https://amzn.to/3brZTXr Katia's 'Huffington Post' articles: https://www.huffpost.com/author/katia-vlachos-834 Seminars, coaching and other services: www.thelonelydiplomat.com/services Please, support my work: www.thelonelydiplomat.com/support Contact me: admin@thelonelydiplomat.com
Finale Week Ryan Brink chats with Survivor Winner Tony Vlachos about his most recent season Survivor S40 Winners at War Follow Ryan on twitter at RyanVBrink Support the show.
Scott & Lindsay talk to Survivor's Ethan Zohn.In a Special BONUS INTERVIEW, Survivor Africa Winner Ethan Zohn (@EthanZohn) drops by to chat with Scott (@SHOTOFYAGER) and Lindsay (@LindsayTheOtter) about his experience returning to the show after all these years to compete on Winners at War, what it was like on Edge of Extinction, what we didn't get to see, why he voted for Natalie & much more!For more Survivor Talk, head to www.Patreon.com/ChallengeManiaEthan's Charity Grassroots Soccer can be found at www.GrassrootsSoccer.Org
Hello, and welcome to Survivor Brothers, the ultimate unofficial podcast from your friends at TV Guide. In this episode, bros Fox Van Allen and Lance Cartelli hit the work-from-home studios one more time to break down "It All Boils Down To This," (S40E14), the stunning season finale of Survivor: Winners at War. Join them as they discuss all the incredible moves that make Tony Vlachos the greatest of all time, and the repeated mistakes that cost Natalie Anderson the win. Plus, did Michele Fitzgerald get cheated out of a deserved second-place finish? The bros also discuss the epic final four fire making challenge between Tony and Sarah Lacina (or just Lacina for short), the respectable real-world reason why Ben Driebergen gave up his game at final five, and whether 16-year-olds have any place competing on the next season of Survivor. Thanks for listening! Those of us here at Survivor Brothers truly appreciate your support all season long. If you want even more Survivor 40 coverage -- and plenty of coverage of Survivor 41 when it happens -- please subscribe to Survivor Brothers on your favorite podcasting app. And if you really like what you hear, leave the bros a review! Learn more about your ad choices. Visit megaphone.fm/adchoices
Hello, and welcome to Survivor Brothers, the ultimate unofficial podcast from your friends at TV Guide. This week, Survivor-obsessed bros Fox Van Allen and Lance Cartelli discuss "The Penultimate Step of the War," S40E13 of Survivor: Winners at War. In these crucial final days of the game, Sarah doubles down on her alliance with Ben and Tony (to her doom?), while Nick Wilson sends himself to the Edge of Extinction using his own damn advantage. Plus, can Jersey Michele Fitzgerald -- or any of the remaining people in the game -- do anything to stop Tony Vlachos from winning $2 million in a cakewalk? And can anyone stop Natalie Anderson from waltzing back into the game? As always, thanks for listening! We'd love it if you'd subscribe to TVGuide's Survivor Brothers on your favorite podcasting app. And if you really enjoyed what you heard, we'd love it if you'd leave us a review as well! Learn more about your ad choices. Visit megaphone.fm/adchoices
Hello, and welcome to another episode of Survivor Brothers, the ultimate unofficial podcast from your friends at TV Guide. This week, Fox Van Allen and Lance Cartelli go in on "Friendly Fire" (S40E12), discussing the continued Immunity challenge dominance of Tony Vlachos over the entire field of Survivor: Winners at War, Kim Spradlin's $2 million decision to eat peanut butter (it did look tasty, though), and the whisper-filled Tribal Council that Denise Stapley was so totally over. Then, stay tuned until the end of the episode, where Lance names his Winners and Losers of the Week (sorry, Spy Nest). Thanks for listening! If you like what you hear, please SUBSCRIBE to the Survivor Brothers on your favorite podcasting app. And if you really like what you hear, please LEAVE US A REVIEW as well. Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome to another episode of Survivor Brothers, the ultimate unofficial podcast from your friends at TV Guide. This week, the bros go deep into Tony Vlachos' incredible performance in "This Is Extortion," S40E11 of Survivor: Winners at War, from his crazy last-minute play at tribal council that snuffed Sophie Clarke's torch to the extortion scheme that set Tony up for his success. It was epic Survivor gameplay and peak Vlachos madness -- but will it all come back to haunt Tony in the end? And stay tuned until the very end of the episode, where Fox and Lance discuss all the remaining players in the game and decide whether they're contenders for the $2 million grand prize... or just pretenders destined for the Edge of Extinction. Thanks for listening! If you like what you've heard, please subscribe to the Survivor Brothers on your favorite podcasting app! And if you really like what you've heard, leave the bros a review! Five stars gang! Learn more about your ad choices. Visit megaphone.fm/adchoices
Tony took our breath away once again. We recapped the 11th episode of Winners at War, in which a queen was dethroned, a maniac took the wheel again, and we just had to sit on our couch and enjoy it all. Subscribe! And follows us on Twitter @SurvivorTopTen, where Josh live-tweets during the show. Our top ten points that we cover in this recap: 10. Nobody wants to talk to Jeremy. 9. Tony is Tony again. 8. Sarah’s fashion line (and social game). 7. Tony goes undercover. Everyone buys it but Kim. 6. Losing the game can ruin people’s lives. 5. Who could we extort that is chaotic? Cuts quietly to Tony. 4. Tony collects fire tokens from friendz. 3. A potentially familiar Immunity challenge 2. The Scramble 1. Sophie goes home a top tier winner.
This week's episode was awesome! Olivia is a good friend of mine who works at First Media, she has a lot of great insight into what it means to be a social media influencer. Olivia's Instagram:https://www.instagram.com/oliviavlachos/Olivia's Blog:https://www.livalittle.me/Support the show (https://www.patreon.com/theklapps)
Phil and Alexa managed to track down David Samson (@DavidPSamson), host of NOTHING PERSONAL WITH DAVID SAMSON (https://plnk.to/NothingPersonal?to=page) as well as the man who successfully touched the shoulder of Garrett Adelstein, setting the tone for Survivor Cagayan as one of the most wonderfully chaotic seasons in Survivor history.
Katia is an experienced expat, coach and speaker. Her advice is essential for first time expats, seasoned expats and repeats alike. She walks you through the critical preliminary decision making stages using 5 core principles as guideposts. Katia and I talked about the best and worst ages to move with children, she shared with me her philosophy on the importance of the preliminary decision stage of a move - regardless of whether that is a move away from, or back to one's "home", and she shared with me her theory on what home means and why it's so important for each of us to really know what we're talking about when we talk about home. You can learn more about Katia at her website: www.katiavlachos.com And purchase her book here: https://amzn.to/2RIKgE5 Join the Expat Repat mailing list: https://forms.gle/6Y3644HCqaWCwBfA8 Follow me on Instagram: www.instagram.com/expatrepat Follow the Expat Repat Facebook page: https://www.facebook.com/expatrepatpod/ Join the Expat Repat Facebook Group: https://www.facebook.com/groups/expatrepat Read my blog, Swiss Lark: www.swisslark.com If you have an idea for an episode, or would like to be a guest on the show, please email me on expatrepat@gmail.com or reach out on Twitter @expatrepat. Consider becoming a Patreon member at www.patreon.com/expatrepat and don't forget to subscribe, rate AND review wherever you get your podcasts. Of course, share with your friends. Thank you for listening!
In my very first podcast episode, I introduce myself to my listeners.You will find out about the many hats I wear in my life, my passions in life and exactly what my podcast show is going to be about.MY MINDSET & WELL-BEING TIP 4 YOU IN THIS EPISODE _ “TAKE WHATEVER RESONATES WITH YOU AND LEAVE THE REST BEHIND.”For regular inspo, come over and join my beautiful facebook - https://www.facebook.com/soul2soulwellness You’ll also find me on Instagram www.instagram.com/kayevlachos_Soul2SoulWellnessIf you have any Q’s for me, please submit them here at kaye@soul2soulwellness.com.auThis episode is brought to you by our partner S2S Floors - www.s2sfloors.com.au. Check them out today, for all your flooring needs Australia wide.You can listen, subscribe and I’d be super grateful, if you can spare a couple of minutes to leave a positive review here in Itunes and Spotify so I can help more people with my podcast.You can learn more about my personal story here –https://www.soul2soulwellness.com.au/about
A Their Story interview with Sean Martin & Marco Ciappelli Guests: Dimitri Vlachos, CMO | Matt Mosley, VP of Products, Cyber Security The organization telling us their story today is Devo. During RSA Conference earlier this year, I had the chance to connect with some of the Devo team members for a quick podcast captured in their booth. One of the things we discussed was the concept of user experience within security applications; you know, the features and capabilities of the software that enables the analysts, managers, and other practitioners to do their jobs. Since that conversation, I’d been thinking about the life and times of a SOC Analyst, yearning to have a follow-up chat to dig deeper into this topic. I wanted to discuss how a good user experience can make a security professional’s job more efficient and—to a certain extent, easier—and how, conversely, a poor user experience could not only affect the time on the job, but also the overall mental health of a security professional. As we were all at Black Hat, we couldn’t miss the opportunity to have this chat. The timing was perfect to have this conversation since the Ponemon Institute and Devo put together a new research-driven report, Improving The Effectiveness Of The SOC. Marco was happy to join me to discuss the results with Dimitri and Matt, and we uncovered some additional elements to consider when a poor user experience is delivered with a security application or service. Without giving everything away, I will leave you with one word: burnout. We looked at this issue with more vigor, exploring how the findings from this research, increased consideration for the SOC analyst and their career lifecycle, and a collection of better tools built with the user experience in mind can make the difference now and in the future. Intrigued? If you use a security product or lead a team that uses security products, you should be. Have a listen and share this with your peers. They will appreciate it. Learn more about Devo on ITSPmagazine here: https://www.itspmagazine.com/company-directory/devo Learn more about Their Story podcasts here: https://www.itspmagazine.com/their-infosec-story
FLASHBACK FRIDAY is back to entertain you as we bring you a popular interview with a popular winner in our chat with Cagayan winner Tony Vlachos! In this chat, we talk to Tony about just how close he came to being on another season, why he was the driving force behind several other moves that other contestants were given credit for on air as well as who he gave a fake idol to and why he went online and posted comments on Survivor blogs and websites with fake profiles during the season airing on TV. Come for the fun, stay for the llama in this iconic chat!★ Support this podcast on Patreon ★
Carol is joined today by Katia Vlachos, Expat Transition Coach and Author of “A Great Move: Surviving and Thriving in Your Expat Assignment." Being a trailing spouse or partner can be an exciting experience but is also challenging from a personal and professional standpoint. Katia shares advice for those re-patriating back to their home countries after time abroad.
In this episode of The Lonely Diplomat podcast, we'll explore the concept of 'home' and what it means to diplomats. This is a topic I explored in my blog post 'The Lonely Diplomat: on home', published on 17 March 2019 (go to www.thelonelydiplomat.com/blog to read). In this episode, you'll hear a great conversation between me and Katia Vlachos, author of the fantastic book: ‘A Great Move: Surviving and Thriving In Your Expat Assignment'. Katia and I chat about the topic of home and moving internationally. Specifically, we talk about why it's important to be brave and to speak up when you're not coping with a move (because you're not alone); how to handle reverse culture shock and many other topics. Katia's professional background is in policy analysis. She holds an MA from the Kennedy School of Government at Harvard and a PhD from the RAND Corporation. Katia is a seasoned expat herself, having lived in eight cities, seven countries and three continents in the past 20 years. She currently lives in Zurich, Switzerland. Her website is www.katiavlachos.com Stay connected with me and my work: www.thelonelydiplomat.com/subscribe
Expat life can lead to a series of important decisions regarding your career, your portable business and also your personal life and family choices. If you are an expat spouse, you might feel that you do not have any other choice than to give up your career or live in countries where you are not happy. “It does not have to be only one conversation” In this episode, with Katia Vlachos, we discuss how to deal with this feeling of “not having the choice” and how to evaluate if you are indeed making conscious choices about your life and career on the move. Katia Vlachos is a researcher and policy analyst by training, with a Master’s from Harvard and a Ph.D. from the RAND Corporation. In the first chapter of her career, she worked for more than a decade as a researcher and defense analyst in the United States and Europe. In her second and current chapter, she followed her passion and built on her personal experience and extensive research to publish her book entitled . (https://www.katiavlachos.com/book/) Katia is also a co-active coach, trained at the Coaches Training Institute (http://www.coactive.com/) (CTI). She works with expats and globally mobile professionals at various stages of their transitions, including international moves, career change or relationship breakdown. What you will learn How to make the choice to say “yes” or “no” to a move abroad, especially as an expat spouse. How to make the choices that will lead to building something meaningful in your life and career. What are the 5 areas of life to consider when making these choices? What to do when there is no alignment in the expat couple. How to know if it is time to stop an expat experience. How to know if it is time to consider divorce if the relationship in the expat couple is not working. Resources and inspiration Check out related podcast episodes and important info on the topic: Check out Katia’s articles and insights on expat divorce: Click here to read! (http://www.diary-of-a-move.com/divorce/) Learn about the legal aspects of expat divorce with an expert on international family law: Click here to listen! (https://tandemnomads.com/tn38-how-to-be-prepared-in-case-of-divorce-within-an-expat-couple/) Get inspiration with this interview on how to reinvent your career with Sundae Bean: Click here to listen! (https://tandemnomads.com/tn68-three-steps-to-career-and-life-reinvention-with-sundae-bean/) Interview with an expat couple and how they made their choices: Click here to listen! (https://tandemnomads.com/tn35-expat-tandem-shanghai-helene-reiter-manfred-girkinger/) Take action now Share with us your insights and what you’ve learned from this episode with the Tandem Nomads Community (https://www.facebook.com/groups/tandemnomads/) (https://pages.convertkit.com/124b0ea4ec/c25eadcbc9) Find Katia online Website (https://www.mastering-green.com) Facebook (http://www.facebook.com/KatiaVlachosCoach/) Twitter (https://twitter.com/vlachosk?lang=en) Linkedin (https://www.linkedin.com/in/katiavlachos)
Seasoned expat, transition coach, and author of A Great Move: Surviving and Thriving in Your Expat Assignment Katia Vlachos helps expats and globally mobile professionals navigate various stages of their moves. She joins Chelsea at 8:30 to talk about the similarities between leaving one's home base and leaving one's partner which, in both cases, is often an invisible grief that requires you to reimagine and rebuild your concept of home.Shedding a light on the complexity of uprooting with your partner, Katia emphasizes the conversations that are crucial to have before any move and admits to not even thinking about what a transition could do to not only her marriage but her concept of self. For instance, not only are expats having to adjust to a new culture but often their identities, both professionally and within their marriage, are having to be renegotiated.In addition to the life of an expat, Katia talks about:+ how the dreaded question—"what did you do today?"—can drive a wedge between couples+ the balance between being real with your child and protecting your child post-divorce+ healthy boundaries within parenting+ the tiers of vulnerability + the significance of being both a relatable figure and the light at the end of the tunnel for a person in transition+ the invisible work of nurturing your child's emotional wellbeing+ finding meaning in your life that's not necessarily linked to your partner+ plus, so much more.—Use CODE “thankyouex” for the month of December on all Chelsea’s coaching services: www.breakupward.com/shopReceive your chosen self-development book with one of Chelsea's signature love letters, when you write an iTunes review for Thank You Heartbreak. Just send a screenshot to Chelsea@breakupward.com or in a DM at www.instagram.com/thankyouheartbreak—To connect with Katia, visit her:Website: www.katiavlachos.comWork with Katia: www.katiavlachos.com/coachingRead her book, A Great Move: Surviving and Thriving in Your Expat Assignment:https://www.amazon.com/Great-Move-Surviving-Thriving-Assignment/dp/1911498606/ref=sr_1_1?ie=UTF8&qid=1535626754&sr=8-1&keywords=a+great+move+katia+vlachosInstagram: www.instagram.com/vlachoskFacebook: www.facebook.com/KatiaVlachosCoachTwitter: www.twitter.com/vlachoskLinkedIn: https://ch.linkedin.com/in/katiavlachos—Work with Chelsea: www.breakupward.com/shopChelsea’s website: www.breakupward.comSign up for Chelsea’s newsletter: bit.ly/tyhbletterConnect and send in your questions and/or letters viawww.instagram.com/thankyouheartbreakOr by email: Chelsea@breakupward.com
Kan vi nå 1 miljard människor med vård från Stockholm 2035? Det vore åtminstone en grym vision att jobba mot tycker vi.
Author Katia Vlachos joins us to discuss her new book A Great Move and what it takes to make a successful move. The step-by-step process described in the book guides you in deciding whether and where to move, planning and preparing for relocation, making the move with minimal stress or surprises and, finally, settling in and creating your new home. Based on extensive research and interviews with expats from diverse backgrounds, the book addresses both the practical and emotional aspects of expat life. Find out more: [website](http://www.katiavlachos.com) Social media links: [LinkedIn](https://www.linkedin.com/in/katiavlachos/) [Twitter](https://twitter.com/vlachosk) [Facebook](https://www.facebook.com/KatiaVlachosCoach/) [Instagram](https://www.instagram.com/vlachosk/) [Entrepreneurial You by Dorie Clark ](https://www.amazon.co.uk/Entrepreneurial-You-Monetize-Expertise-Multiple/dp/1633692272/ref=sr_1_1?ie=UTF8&qid=1530787364&sr=8-1&keywords=entrepreneurial+you)
Dr. Paul Wong: Welcome to the monthly podcast, On The Beat, for Circulation: Arrhythmia and Electrophysiology. I'm Dr. Paul Wong, editor in chief, with some of the key highlights from this month's issue. We'll also hear from Dr. Suraj Kapa, reporting on new research from the latest journal articles in the field. In our first article, Ratika Parkash and associates examined whether the outcomes following escalated antiarrhythmic drug therapy, or catheter ablation, depended on whether ventricular tachycardia with amiodarone refractory or sotalol refractory in patients with prior myocardial infarction in the VANISH study. At baseline, 169, or 65%, were amiodarone refractory, while the remaining were sotalol refractory. Amiodarone refractory patients had more renal insufficiency; 23.7% versus 10%. Worse, new ARC Heart Association class, 82.3% versus 65.5% class II or III; and lower ejection fraction, 29% versus 35%. Within the amiodarone refractory group, ablation resulted in a reduction of any ventricular arrhythmias compared to escalated drug therapy, with a hazard ratio of 0.53, P = 0.02. Sotalol refractory patients had trends towards higher mortality in VT storm with ablation, with no effect on ICD shocks. Within the escalated drug arm, amiodarone refractory patients had a higher rate of composite endpoint, with a hazard ratio of 1.94 and a P value of 0.01. In a trend toward higher mortality, hazard ratio 2.4, P = 0.07. While mortality was not different between amiodarone and sotalol refractory patients within the ablation treatment group. In our next study, Junaid Zaman and associates examined 57 cases in which local ablation of persistent atrial fibrillation terminated to sinus rhythm or organized tachycardia. The authors analyze unipolar electrograms collected during atrial fibrillation from multi-polar basket catheters to reconstruct isochronal activation maps for multiple cycles, and computational modeling and phase analysis were used to study mechanisms of map variability. At all signs of atrial fibrillation termination, localized, repetitive activation patterns were observed, 21% with complete rotational activity, 46% with partial rotational circuits, and 33% with focal patterns. In computer simulations incomplete segments of partial rotations coincided with areas of slow conduction, characterized by complex, multi-component electrograms. In our next article, Matthew Kalscheur and associates sought to use a novel machine-learning approach to predict outcomes following resynchronization therapy in the companion trial. The random forest algorithm resulted in the best performing model. In 595 CRTD patients in the companion trial, 105 deaths occurred, with a median follow-up of 15.7 months. The survival difference across subgroups differentiated by bundle branch block morphology and cure restoration did not reach significance, P = 0.08. The random forest model, however, produced quartiles of patients with an eight-fold difference in survival between those with the highest and lowest predictive probability for events, hazard ratio 7.96 with a P value of less than 0.0001. The model also discriminated the risk of composite endpoint of all cause mortality, or heart failure hospitalization, better than subgroups based on bundle branch block morphology and cure restoration. Future studies are needed to validate this model in other populations. In our next paper, Amr Barakat and associates examined the clinical outcomes of trans-venous lead extraction for CIED infection based on renal function. The authors examined 1,420 consecutive patients undergoing trans-venous lead extraction of infected CIEDs over a 14 year period. Groups with normal renal function, Group 1, consisting of 1,159 patients, Group 2, 163 patients with renal dysfunction not requiring dialysis, and Group 3, 98 patients on dialysis. Complete procedural success rates were comparable in the three groups: 94%, 96%, and 94% in Groups 1, 2 and 3, respectively. This was not statistically significant. The mortality rates were significantly higher in dialysis patients at one month. The procedure-related complication was 12.2% in dialysis patients versus 6.5% in Group 1 and 6.1% in Group 2. Other factors associated with mortality were lead material retention, functional New York Heart Association Class, and occurrence of procedural complications. In our next paper, Eric Johnson and associates studied the contribution of the current ITO, two left ventricular re-polarization in the human heart, since the current has been shown to have an important role in animal models. The authors found that using whole-cell voltage clamp recordings from myocytes, isolated from the left ventricle, non-failing human hearts, that there were two, distinct transient currents, ITO fast and ITO slow. The two currents have significantly different rates of recovery from inactivation and pharmacological sensitivities. ITO fast recovers in about 10 milliseconds, 100 times faster than ITO slow, and it's selectively blocked by KV4 channel toxin SNX 482. Using current clamp experiments, they found that regional differences in action potential wave forms, with a notch in phase one in the left ventricular subepicardial myocytes. In failing, left ventricular subepicardial myocytes, ITO fast was reduced, while ITO slow was increased. In addition, the notch and plateau potentials were depolarized, and action potential durations were prolonged, both statistically significantly. Slowing ITO fast inactivation results in a dramatic action potential shortening. The authors concluded that remodeling of ITO fast in failing, human left ventricular subepicardial myocytes, attenuates transmural differences in action potential wave forms. In our next paper, Ravi Vaidyanathan and associates examine the interaction between Caveolin 3 domain in the inward rectifier potassium channels. Although the IK1 current is mainly composed of Kir2.1, there are Kir2.2 and Kir2.3 heterotetromerisoforms that occur and modulate the IK1 current, but these have not been studied. Kir2.x isoforms have unique, subcellular co-localization in human cardiomyoctyes and co-immunoprecipitate with Cav3. Using induced pluripotential stem-cell-derived cardiomyocytes, the LQT9 Cav3 mutation, F97CCav3 resulted in actual potential prolongation. Based on the technique FRET, which is Fluorescent Resonance Energy Transfer, the authors calculated the distance between KR2.2 and cath ray proteins to be 6.61 nanometers. LQT9 is caused by Cav3 mutations. Prior work has shown that F97CCav3 mutation increases the late sodium current, and decreases KR2.1 current density by distinctive mechanisms. This study extends the authors' previous observations on the impact of LQT9 Cav3 mutation on Kir2.1 current, by demonstrating that mutation affects the Kir2.2 current. LQT9 causing Cav3 mutation differentially regulates current density and cell surface expression of Kir2.x homomeric and heteromeric channels. The authors show that the mutation does not affect Kir2.3 current, but the heterotetromer Kir2.2-2.3 demonstrated loss of function. Using the Li-Rudy [inaudible 00:09:45] model and myocyte mathematical model, the authors' data suggest that both loss of IK1 and increased sodium L are required for arrhythmia generation in LQT9. In our next study, Christophe Teuwen and associates use high resolution epicardial mapping electrodes, 128 or 192, with an inter-electrode distance of 2.0mm of the entire atrial surface in 164 patients. These patients were undergoing open-chest cardiac surgery. This study was designed to examine the conduction of atrial extrasystoles. The authors found that a higher degree of aberrancy was associated with a higher instance of conduction disorders. Most conduction disorders were provoked by atrial systoles emerging as epicardial breakthroughs. Atrial extrasystoles cause most conduction disorders in patients with left atrial dilatation or diabetes mellitus. In our next paper, Yuki Komatsu and associates examine 31 patients with idiopathic ventricular arryhthmias, using a two french microcatheter placed in a communicating vein between the great cardiac vein and small cardiac venous system, which passes between the aortic and pulmonary annulae, and is located in close associated with the left ventricular summit. They found that 14 patients had summit ventricular arryhthmias. The remaining 17 patients control group had ventricular arryhthmias originate from the right ventricular outflow track in the aortic cusps. In patients with summit ventricular arryhthmias, the earliest activation during ventricular arryhthmias in the summit, preceded to cure as onset by 34 milliseconds. The summit ventricular arryhthmias exhibited inferior axes, negative polarity in lead one, deeper Q wave in AVL than AVR, nonspecific bundle branch morphology with an RS ratio in lead V1 of 0.67, distinguishing them from arryhthmias originating from the right ventricular outflow track or right ventricular cusp. Overall, ablation success was achieved in 10, or 71% of patients with summit ventricular arryhthmias, and 88% in the control group, P = 0.24. In our final paper, Deepak Padmanabhan and associates examine differences in mortality in patients with non-MRI conditional CID undergoing brain MRI compared to controls. Patients with CIDs undergoing brain MRI were compared with three control groups matched for age, sex, imaging year, and type of CID. These groups included 1) no CID and brain MRI, 2) CID in brain-computed CT, and 3) no CID in brain CT. They estimated all cause mortality at five years for CID MRI group, was not significantly different from patients who underwent CT, with or without a device. There was a significant increase in the mortality between CIED versus no CID MRI groups, hazard ratio 1.46 with a P value of 0.04. That's it for this month, but keep listening. Saraj Kapa will be surveying all journals for the latest topics of interest in our field. Remember to download the podcasts On the Beat. Take it away Saraj. Saraj Kapa: Thank you Paul, and welcome back to On the Beats where this month we'll be focusing on articles that are particularly hard-hitting, published across the literature in December of 2017. It's my pleasure to introduce 20 different articles that seem to have either particular interest or might change the field in the future. First, within the area of atrial fibrillation, we'll focus within the area of anticoagulation and stroke prevention. In the Journal of the American College of Cardiology, Vivek Reddy et al published on the five-year outcomes after left atrial appendage closure, from the Prevail and Protect AF trials. They included a total of 1,114 patients, with a total of 4,343 patient years of follow-up, randomized two to one to closure versus Warfarin. While ischemic stroke and systemic embolism of [inaudible 00:14:32] were numerically higher with closure, this did not reach statistical significance in terms of hemorrhagic stroke, unexplained death, and post-procedure bleeding favor left atrial appendage closure. These findings further support a role for left atrial appendage closure in the specific groups of patients enrolled in the Protect and Prevail Studies. Of course, we always need to understand, that extrapolation to patients who may not have met inclusion criteria will be difficult. In particular, given both trials had their own fundamental limitations in the Prevail study. There was a relatively low rate of [inaudible 00:15:09] in the Warfarin arm. And in turn, there was a relatively high complication rate in Protect AF with left atrial appendage closure. Part of the differences might be due to the fact that, with more experience, complication rates might decrease. Furthermore, a comparison with more novel agents, such as the new oral anticoagulants, remains to be seen. Next, within the realm of cardiac mapping and ablation for atrial fibrillation, we review an article by Vlachos et al published in the Journal of Cardiovascular Electrophysiology entitled Low-Voltage Areas Detected by High-Density Electroanatomical Mapping for Recurrence of Ablation after a Paroxysmal Atrial Fibrillation. They presented the results from a series of 80 patients undergoing ablation for paroxysmal atrial fibrillation, performing high-density voltage mapping to characterize the total area involved by low voltage. They demonstrated, when low voltage areas, defined as less than 0.4 millivolts, were seen in greater than 10% of the left atrial surface area, this served as an independent predictor of atrial fibrillation recurrence. These data support prior research, including that of MRIs, suggesting the characterization of the atrial substrate may correlate with likelihood of ablation success. Identifying methods however, to accurately and reproduce will identify these patients with more atrial substrate prior to ablation, remains to be seen. The importance of this, however, is our ability to better counsel patients on the likelihood of treatment success. Next within the realm of atrial fibrillation, we review elements of risk stratification managements. First, in the December issue of the Journal of American College of Cardiology, Takimoto et al published on how Eplerenone may reduce atrial fibrillation burden without preventing atrial electrical remodeling. In a randomized controlled ovine atrial tachy pacing model of atrial fibrillation. The authors provided daily, oral Eplerenone and compared this with a placebo. They showed that Eplerenone significantly reduced the rate of left atrial dilatation, with less smooth muscle actin protein, atrial fibril [inaudible 00:17:17]. Furthermore, Eplerenone further prolonged the time to persist in atrial fibrillation in 26% of animals. However, interestingly, Eplerenone did not prevent AF-induced electrical remodeling. These data suggest that Eplerenone, or other medications that can be used to prevent or reverse structural remodeling, may offer an upstream therapy to reduce atrial fibrillation burden, and decrease likely the persistent atrial fibrillation. Giving the ever-growing population of patients suffering from atrial fibrillation, identifying upstream approaches to prevent it will be critical. Of course, these need to be taken with due consideration, however. Specifically, the model used here, namely that of an atrial tachy pacing model, might not be applicable to all human atrial fibrillation. Thus, whether or not such therapies actually offer benefit in clinical models, is as of yet unclear. Finally, from the realm of atrial fibrillation, we review the article by Rowin et al published in circulation entitled Clinical Profile of Consequences of Atrial Fibrillation Hypertrophic Cardiomyopathy. In patients presenting with hypertrophic cardiomyopathy, atrial fibrillation is known to be a significant co-morbidity. However, the implications of atrial fibrillation in terms of worsening of heart failure status, or long-term morbidity mortality are less clear. Rowin et al reviewed the natural history of atrial fibrillation amongst 1,558 patients, prospectively followed at a single center. Nearly 20% of the population developed atrial fibrillation with the majority having symptomatic paroxysmal atrial fibrillation. However, atrial fibrillation was not associated with any increase in cardiovascular mortality or worsening of heart failure status. Furthermore, mortality that was directly related to atrial fibrillation was nearly exclusively related to thrombolic stroke. Anticoagulation [inaudible 00:19:13] reduced this risk. The traditional scoring systems fared poorly in assessing the stroke risk of this population. About 121 patients underwent invasive rhythm control approaches, including 72 patients undergoing maze and 49 catheter ablation. The success rate of maze was significantly greater at around 75%. These data are important when counseling hypertrophic cardiomyopathy patients presenting with new-onset atrial fibrillation. While it is clear that paroxysmal atrial fibrillation has a significant impact on symptoms and quality of life, it does not cause worsened, overall, long-term outcomes. However, it does highlight the importance of anticoagulation in this population, nearly irrespective of the underlying risk score. In terms of rhythm control options, it appears that rhythm control options can be successful in these patients. Finding that catheter ablation is associated with a 40 to 50% success rate is in keeping with prior published data. Thus, consideration of when a patient needs to be referred to maze, needs to be considered in the clinical inpatient context. Changing gears, we will next review articles within the realm of ICDs, pacemakers, and CRT. In the New England Journal of Medicine this past month, Nazarian et al published on their experience regarding the safety of magnetic resonance imaging in patients with cardiac devices. They performed a prospective non-randomized study of the safety of, specifically, 1.5 tesla-strength MRI scans on legacy. In other words, not MRI conditionally-safe pacemakers and defibrillators. A total of 2,103 scans were done among 1,580 patients. They demonstrated no long term clinically significant adverse events. Nine patients did experience a reset to a backup mode, though eight of which were transients. The most common change seen acutely was a decrease in PVA amplitude in one percent of patients, and in a long term follow-up, 4% of patients experiencing a decrease in PVA amplitude, increase in atrial catheter sheer threshold, or increase in right or left ventricular capture threshold. However, none of these events were considered clinically significant. Furthermore, there was not a good [inaudible 00:21:23] group to know if this long term change in amplitudes or thresholds might have been seen in patients who had devices that were not exposed to MRI. These findings are complimentary to multiple, prior, published reports, indicating the safety of performing MRIs under clinical protocol in legacy pacemakers and defibrillators. It calls into question whether MRI conditional devices truly offer an additional safety factor furthermore, over legacy devices. Next we review an article by Lakkireddy et al published in Heart Rhythm entitled A Worldwide Experience, the Management of Battery Failures and Chronic Device Retrieval of the Nanostim Leadless Pacemaker. Lakkireddy et al reported their large multi-center experience on the overall risk of battery failure. Amongst 1,423 implanted devices there were 34 battery failures occurring, on the average, three years after implants. Furthermore, about 73 patients underwent attempted device retrieval, and this was successful in 90%, with the seven failures of retrieval being due to either inaccessibility of the docking button, or dislodgement of the docking button in one patient, in whom it embolized to the pulmonary artery. An additional 115 patients interestingly received an additional pacemaker after release of the device advisory. These data suggest that there may be as high as an overall 2% risk of battery failure with the Nanostim device, even late after implants. This highlights the need for close follow-up, even if the battery appears relatively stable up to two year after implants. Furthermore, almost 10% of devices cannot be successfully retrieved. However, in those patients, even with re-implantation of a separate device, there was no device-device interaction seen. Further innovation will be needed to optimize device longevity, and close follow-up of all patients undergoing implantation will be critical to understand the overall long term efficacy and safety when compared to other traditional devices. Finally, within the realm of device care, we focus on an article by Kiehl et al, again published in Heart Rhythm this past month entitled Incidence and Predictors of Late Atrial Ventricular Conduction Recovery Among Patients Requiring Permanent Pacemaker for complete heart block after cardiac surgery. They reviewed the likelihood of recovery of conduction in their retrospective cohort of 301 patients. Interestingly, 12% of patients had recovery of AV conduction on average six months after surgery. Those who did not recover tended to more likely have preoperative conduction abnormalities. Saraj Kapa: Findings that suggested a higher likelihood of long term conduction recovery included female sex and the existence of transient periods of AV conduction postoperatively. These data highlight that recovery of AV conduction is possible in a significant number of patients undergoing cardiac surgery. However, being able to predict long term recovery may assist in device selection, to avoid more costly device implantations that may not be needed over chronic follow-up. Prospective studies amongst larger numbers of patients are needed to better understand mechanisms of block, mechanisms of recovery, an optimal device in patient selection. Changing focus, we will next review two articles within the realm of supraventricular tachycardias. First we read an article by Han et al published in JACC Clinical Electrophysiology, entitled Clinical Features in Sites of Ablation for Patients With Incessant Supraventricular Tachycardia From Concealed Nodofascicular and Nodoventricular Tachycardias. Han and group describe three cases of concealed nodovascicular, nodoventricular re-entrant tachycardias, and focus on the different mechanisms of proving their participation in tachycardia. In all cases, atrial ventricular re-entering tachycardia was excluded. Successful ablation for these tachycardias occurred either at the slow pathway region, the right bundle branch, or the proximal coronary sinus. This is the first described case of incessant, concealed tachycardias related to these pathways. The importance of this article highlights an understanding the mechanisms proving the contribution to tachycardia, and the importance of recognition when performing electrophysiology studies, and being unable to reveal traditional mechanisms, which exist in most patients, such as atrial tachycardia, AVNRT or AVRT. Next we review an article by Guo et al published in Europace entitled Mapping and Ablation of Anteroseptal Atrial Tachycardia in Patients With Congenitally Corrected Transposition of the Great Arteries: Implications of Pulmonary Sinus Cusps. They reviewed three separate cases of anteroseptal atrial tachycardias in the setting of congenitally corrected transposition. They demonstrated that in these cases, there was successful ablation performed with the pulmonary sinus cusps. The result is successful and durable suppression. The reason this article is important lies in the fact that it's critical to understand both cardiac anatomy and cardiac nomenclature. The pulmonary valve in CCTJ is affectively the systemic ventricular arterial valve, given that the right ventricle is the systemic ventricle. Thus, mapping in this region of CCTJ abides the same principles as mapping the aortic valve in structurally normal hearts for similar tachycardias. However, understanding the nomenclature and that despite the variant anatomy, the utility of similar approaches to mapping of the systemic outflow are important when matching these complex, congenital anatomy or arrhythmia patients. Changing gears yet again, we review an article within the realm of sudden death and cardiac arrest. Baudhuin et al published in Circulation and Genetics entitled Technical Advances for the Clinical Genomic Evaluation of Sudden Cardiac Death. Baudhuin et al reviewed the utility of formal and fixed paraffin-embedded tissue, which is routinely obtained in an autopsy, to perform post-mortem, genetic testing. One of the main limitations to advising family members who have had prior family history of sudden death in closely related relatives, is that blood is often not available to perform DNA screening late after death. DNA however is often degraded in the tissues that are commonly available at autopsy, namely the formal and fixed paraffin-embedded tissues. The authors sought to evaluate if your next generation techniques could make these types of tissue adequate for diagnosis. They demonstrated amongst 19 samples, that performance characteristics were similar between whole blood and these tissue samples, which could be as old as 15 years. It can be critical to identify disease-causing mutations in family members, as individuals who might not yet be affected, but at risk, need to know about that overall risk. Given that decision to sequence might also not be universally applied at all centers, or in all situations, oftentimes these paraffin-embedded tissues might be the only available option, sometimes over a decade after death. This represents the first report of using next-generation sequencing approaches to successfully and accurately sequence for specific mutations using paraffin-embedded tissue. This may offer additional options to help family members achieve diagnoses for sudden death-inducing conditions. Within the realm of cellular electrophysiology, we review an article by Lang et al published in Circulation Research entitled Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart. Lang et al reviewed the effect of cell-cell coupling on the likelihood of triggered arryhthmias. In a [inaudible 00:28:45] model, they demonstrated the myocytes that are poorly synchronized with adjacent myocytes were more prone to triggered activity due to abnormal calcium handling when compared to myocytes with normal connection to adjacent cells. Thus, adequate coupling leads to voltage clamping during calcium waves, thus preventing triggering arrhythmias. While poorly coupled myocytes aren't able to to this due to a weakened currency, making them more prone arrhythmogenesis. These data highlight another critical cellular basis for arrhythmogenesis. In heart failure, while the focus for clinical management is typically areas of scar, there's clearly a role at the cellular level where cell-cell coupling abnormalities can lead to dynamic changes that can increase tendencies to arrhythmogenesis. The role in understanding the varying, arrhythmogenic risk based on varying factors, is important, and might have importance in the future advances in mapping technologies. Changing gears, we review an article published in the Journal of the American College of Cardiology by Mazzanti et al within the realm of genetic channelopathies entitled Hydroxyquinoline Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. They reviewed a cohort of 17 patients and demonstrated that hydroxyquinoline resulted in a reduction of arrhythmic events from 40% to 0% of patients. QTc prolongation was seen in all patients. These data clearly demonstrate that hydroxyquinoline plays a role in lowering the incidence of arrhythmic events in patients suffering from short QT syndrome. However, it's important to note that in many markets, quinoline has been difficult to access. In the specific case of QT syndrome thus, there's clearly a role for hydroxyquinoline. However, it also must be noted, the comparative efficacy with more commonly available drugs still needs to be evaluated. This past month has been of particular interest in the realm of ventricular arrhythmias, with multiple, potentially ground-breaking articles. One of the well-recited articles published this past month already is by Cuculich et al entitled Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia published in the New England Journal of Medicine. Cuculich et al reported the first in-human data on the use of stereotactic body radiation therapy to perform noninvasive ablation of ventricular arryhthmias. Using a combination of noninvasive electrocardiographic imaging curing ventricular tachycardia, and stereotactic radiation, patients were treated with a single fraction of 25 [inaudible 00:31:15] while awake. A total of five patients were included with a mean ablation time of only 14 minutes. During the three months prior to treatment, there was a total of 6,577 VT episodes seen, and during a six week post-ablation period, considered a blanking period, there were 680 episodes. After this blanking episodes, there were only four episodes of VT seen over the ensuing 46 patient months. This study is important because it reflects the first in-human proof of concept that noninvasive ablation using radiation therapy traditionally as for treatment of solid tumors, may be affective in targeting cardiac tissue. Furthermore, modern techniques such as noninvasive electrocardiographic imaging might allow for a fully noninvasive experience for the patients. This is a vast advance seen within the realm of cardiac electrophysiology. In the early days, all we could do was map invasively and then have to go to much more invasive, open-heart surgery to treat arryhthmogenic substrates. Since the advent of catheter and radiofrequency ablation, surgical ablation is relatively fallen by the wayside, to a less invasive approaches. A completely noninvasive approach to successfully targeting tissue is potentially ground-breaking. However, there are several limitations in this study that can only be ascertained by reading the actual article. When we actually review the patients included, the long term follow-up was limited to only four patients, as one patient actually died within the blanking period, and in fact, this patient suffered from the largest burden overall of VT. Furthermore, amongst the remaining four patients, one required a redo ablation within the blanking period, and one had to be restarted on amioderone after the blanking period was over. Thus further data is really needed to clarify efficacy, given the overall success rate appears to be less than 50% on a per patient basis. Though on an overall episode basis, there was significant reduction. The exact type of radiation to be used also needs to be considered, within the realm of solid oncology. Stereotactic radiation is considered an older modality, with proton beam, and more recently, carbon beams offer more directed therapy. Thus, a lot more data is required to identify the promise of radiation therapy. Though again, this is a significant advance. Next, within the realm of invasive electrophysiology, we review an article by Turagam et al published in the JACC Clinical Electrophysiology entitled Hemodynamic Support in Ventricular Tachycardia Ablation: An International VT Ablation Center Collaborative Group Study. The utility of hemodynamic support during VT ablation is relatively unclear. Studies have been variable and limited. This group included 1,655 patients who underwent 105 VT ablations using hemodynamic support with a percutaneous ventricular assist device. Those undergoing support overall tend to be sicker, including lower ejection fractions and [inaudible 00:34:07] classes, and more VT events, including ICD shocks and VT storm. Hemodynamic support use interestingly, was an independent predictor of mortality with a hazard ratio of 5, though there was no significant difference in VT recurrence rates irrespective of the subgroup considered. These data indicate that, while patients are receiving hemodynamic support were overall sicker, there was no clear incremental benefit in use of hemodynamic support in terms of long term outcomes. In the area of substrate ablation, whether use of hemodynamic support to facilitate mapping during VT, actually alters outcomes remains to be seen. This study highlights the potential importance of randomized clinical approaches to better evaluate whether hemodynamic support truly alters the long term outcomes of the VT ablation. Next, we review an article by Munoz et al that focuses more on prediction of those patients who might be at risk for ventricular arrhythmias, again published in the last edition of JACC Clinical Electrophysiology and entitled Prolonged Ventricular Conduction and Repolarization During Right Ventricular Stimulation Predicts Ventricular Arrhythmias and Death in Patients With Cardiomyopathy. Munoz et al reviewed the relationship between paced QRS and pace Qtc and long term risk. A total of 501 patients with mean ejection fractions of 33% were included. Longer paced ventricular QRS and Qtc was associated with a higher risk of ventricular arrhythmia, and all caused death or arrhythmia, irrespective or ejection fraction. A paced QRS duration of 190 milliseconds was associated with 3.6 fault higher risk of arrhythmia, and a 2.1 fault higher risk of death or arrhythmia. These data suggest that findings during [inaudible 00:35:47] pacing and otherwise normal rhythm, including paced QRS and QTc may independently result in elevation of overall risk of ventricular arrhythmia and death. Physiologically these data make sense. In light of the fact that longer cure restorations are probably related to a greater degree of myopathy. While these data offer a prognostic indication, whether they alter outcomes or decision making regarding ICM implantation, remains to be seen. Next, also published in JACC Clinical Electrophysiology, Vandersickel et al reviewed a more cellular basis for toursades in an article entitled Short-Lasting Episodes of Toursades de Pointes in the Chronic Atrial Ventricular Model Have Focal Mechanism While Longer-Lasting Episodes are Maintained by Reentry. Vandersickel et al reviewed the mechanisms underlying toursades, and demonstrated that both focal and reentry mechanisms may exist. In five canines they used broadly distributed neuro electrodes to simultaneously map across the heart. They demonstrated that initiation and termination was always focal, but longer and non-terminal episodes always had reentry mechanisms. These data suggest that the mechanisms underlying toursades actually reflect a spectrum of potentially dynamic, electrophysiologic phenomenon the heart, including both focal and reentry activity. Understanding these mechanisms, and the fact that focal mechanisms almost universally underlie initiation may bring into consideration the optimal treatments whether in the form of pacing and defibrillation techniques or medication techniques for toursades. Finally, in the realm of ventricular arrhythmia, we review an article published in the last month's edition of Heart Rhythm by Penela et al entitled Clinical Recognition of Pure Premature Ventricular Complex-Induced Cardiomyopathy at Presentation. As we know, it's sometimes difficult to recognize patients when they present with frequent PVCs and a depressed injection fraction in terms of, whose injection fractions are purely caused by the presence of PVCs, and whose PVCs are only exacerbated by the presence of an underlying myopathy. The group included 155 patients and excluded all patients who did not normalize their elevated ejection fraction, or who had previously diagnosed structural heart disease, leaving a total cohort under consideration, of 81 patients. About 50% were diagnosed as having a PVC-induced cardiomyopathy on the basis of normalization of elevated function after PVC suppression. While the remainder was considered to have PVC exacerbated cardiomyopathy on the basis that things did not entirely resolve, and thus had an independent mechanism for nonischemic myopathy. Characteristics that suggested patients with a lower likelihood of EF normalization included those with longer intrinsic QRSs, above 130 milliseconds, a lower PVC burden of baseline, considered less than 17%, and larger [inaudible 00:38:33] greater than 6.3 cm. PVCs as a cause of [inaudible 00:38:35] are obviously a well-recognized treatable cause of myopathy, however again, it might be difficult to differentiate. Those patients whose PVCs are a result of the underlying myopathy versus those whose PVCs are the cause, and for whom ablation or suppression may reverse the myopathic process. The work of Penela et at offers an initial attempt at helping differentiate these processes, however validation of larger cohort is necessary. Next we review an article within the realm of syncopy entitled Prohormones in the Early Diagnosis of Cardiac Syncopy by Badertscher et al published in the Journal of the American Heart Association this month. They review the utility of circulating prohormones [inaudible 00:39:14] autonomic dysfunction or neurohormonal abnormalities, to differentiate cardiac from non-cardiac causes of syncopy in the emergency departments. They measured four novel prohormones in a multi-center study. In the emergency departments there is a specific protocol used to determine the perceived likelihood of the cause of syncopy to be cardiac versus non-cardiac. In addition to this, the prohormones are drawn. After this, everyone's final diagnosis was reached. Two independent cardiologists reviewed the cases to determine if it was a truly cardiac or non-cardiac cause of syncopy. Among 689 patients included, 125 overall were adjudicated as cardiac syncopy. Measure of the specific marker MR-proANP in combination with emergency department suspicion of syncopy, performed better than suspicion alone, to differentiate cardiac causes of syncopy. A combination of a circulating MR-proANP, less than 77, picomoles per liter, an [inaudible 00:40:17] probability of cardiac syncopy could be less than 20%, had a very high sensitivity negative predictive value of 99%. The significant resources are often used to manage patients with syncopy presenting to the emergency departments, and it's often extremely difficult at this stage to differentiate cardiac from non-cardiac causes of syncopy. And the amount of evaluation that can be done in the emergency department is often limited. Cardiac caused of syncopy are not good to miss, however, since these can include ventricular arrhythmias, and transient AV block, that might result in death as well. As is well-recognized, emergency department evaluation in clinical [inaudible 00:40:49] are limited in terms of their utility. This raises the utility of objective measures to help differentiates. These data suggest that circulating prohormones [inaudible 00:40:59] your hormonal function drawn during your emergency department evaluation, may be a useful adjunct to differentiate cardiac from non-cardiac syncopy. Whether they can be used to prospectively differentiate those patients requiring inpatient admission or now, however, remains to be seen. The last two articles we'll choose to focus on will fall under the realm of broader, other EP concepts. The first article we will review is by Varghese et al published in Cardiovascular Research entitled Low-Energy Defibrillation With Nanosecond Electric Shocks. Varghese et al reviewed the potential of low-energy nanosecond duration shocks for defibrillation in rapid hearts. In induced fibrillation examples, the repeated defibrillated nanosecond impulses as low as three kilovolts demonstrated effective defibrillation. The energy required is significantly lower than from monophasic shocks and longer pulse durations. Furthermore, there was no detectable evidence of electroporation, namely cardiac or so injury after defibrillation. Using nanosecond impulses, it may be feasible to defibrillate the heart with significantly lower energies. The implications for patients experiencing defibrillation, for example pain, is unclear without in-human studies. However, the ability to use lower energies could have implications in battery life. Further [inaudible 00:42:11] studies will be critical to study ambulatory efficacy as this research is performed in [inaudible 00:42:19] hearts. Finally, we review an article published in Circulation entitled Mortality in Supravascular Events After Heart Rhythm Disorder Management Procedures by Lee et al. Amongst three centers, a retrospective cohort study regarding the mortality and risk of supravascular events, was performed. They included a variety of heart rhythm [inaudible 00:42:40] procedures, including defibrillation threshold testing, lead extraction, device implant, and invasive electrophysiology studies and ablation procedures. Amongst 48,913 patients, 62,065 procedures were performed and an overall mortality of .36% was seen. Supravascular [inaudible 00:42:58] was lower at .12%. Interestingly, and expectedly, the highest risk was seen with lead extraction patients, with an overall mortality risk of 1.9%. Less than half of the deaths seen, however, were directly attributable to the procedure itself. The most common cause of procedural death was cardiac tamponade, largely seen amongst device implant patients. This is critical, as the number of ablation and other invasive electrophysiology procedures performed, is increasing. These data provide a large, contemporary experience regarding the overall risk attributable to a variety of heart rhythm disorder procedures. Interestingly, half of the procedure related deaths were associated with device implantation procedures. With the predominant cause being tamponade, highlighting the importance of early recognition of this treatable complication. Tamponade may not always be considered as a major issue after device implantation, however these data clearly suggest that it is. In addition, extraction, as expected, carried the highest incident of both supravascular events and mortality. Though, this is likely related to the higher rate of core morbidity in this population, including active infection. In summary, this month, we have reviewed 20 articles in various areas of electrophysiology published across the literature. Particularly high impact articles range from those reviewing experience regarding left atrial appendage closure and the efficacy of this, to the utility of using atrial fibrillation to predict risk and long term morbidity and mortality in hypertrophic cardiomyopathy, to further evidence regarding the safety of magnetic resonance imaging in legacy pacemakers and defibrillators, and novel considerations regarding supraventricular tachycardias and there diagnosis and management, especially invasively. Other potential groundbreaking articles included evidence that we can successfully use formal and fixed paraffin-embedded tissue that can be as old as 15 years, to successfully identify genetic mutations that might be responsible for sudden death. And evidence that using novel techniques, we might be able to perform completely noninvasive therapies for arrhythmias by using radiation therapies. However questions were also raised such as regarding the role of hemodynamic support for VT ablation. How to better differentiate those patients who will have recovery of AV conduction from those who won't, as they meet class I indications post cardiac surgery? And whether other factors such as right ventricular pacing during [inaudible 00:45:28] study might further differentiate patients at risk for ventricular arrhythmias in spite of a low ejection fractions. Many of the papers had to deal with tranlational work that still remains to be proven in terms of value at a clinical level, such as demonstrating mechanisms underlying trousades de pointes. Or the potential value of low-energy defibrillation with nanosecond electric shocks. Clinical protocols involving the use of prohormones in the early diagnosis of cardiac syncopy. How to differentiate PVC induced from other causes of myopathy, and how to manage, in the long term, these devices. Also, likely requires further study. Finally, covering all areas of electrophysiology, we reviewed one large article focusing on mortality in supravascular events after heart rhythm management disorder procedures at large. This article highlights the importance of considering institutional experience and reporting it to use as a benchmark to help better optimize our counseling of patients, as well as our procedures and protocols. I appreciate everyone's attention to these key and hard-hitting articles that we just focused on from this past month of cardiac electrophysiology across the literature. Thanks for listening. Now, back to Paul. Dr. Paul Wong: Thanks Seraj. You did a terrific job surveying all journals for the latest articles on topics of interest in our field. There's not an easier way to stay in touch with the latest advance. These summaries, and a list of all major articles in our field each month, can be downloaded from the Circulation Arrhythmia and Electrophysiology website. We hope you'll find the journal to be the go-to place for everyone interested in the field. See you next month.
Dr. Stacey Vlachos is a graduate of Michigan State University in East Lansing, Michigan. He graduated with a B.S. with honors in 1976. He then went on to attend the University Michigan Dental School and graduated in 1982. Following his graduation, he practiced with the World-renowned Dr. Carl Misch in his private and hospital practice for several years, working side by side with him, to learn the field of implantology. He graduated from the 20-month Course thru he Misch International Institute where he was invited to join the staff as a lecturer, prosthetic, and surgical instructor. He holds dental Licenses with several states and has practiced for 35 years. He became a diplomate in 1992 of the American Board of Oral Implantology, and a diplomate in 1994 of the International Congress of Implantology. He also became a Diplomate of the American Society of Osteointegration, and American College of Oral Implantology. Dr. Vlachos is a fellow of the ICOI, American Society of Osteointegration, American College of Oral Implantology and American Board of Oral Implantology. Dr. Vlachos has earned a national reputation for his clinical experience and technical expertise. He has helped to develop the field by participating in ground breaking procedures which resulted in implantology becoming the fastest growing field in Dentistry. Dr. Vlachos currently practices in Naples, Florida. He is the founder of the One and One Surgical Implant Training Program. This is an individualized surgical program designed for inexperienced Dentists to perform surgical procedures, on their own patients with Dr. Vlachos and his staff assisting them and working together side by side. Dr. Vlachos can be reached at 239-560-7365 and at drvlachos@gmail.com www.RecordLinc.com
This week we interviewed Tony Vlachos. He was the second person to leave the game in episode 1 of Survivor Game Changers. It was easy to understand why Tony was invited back for this season. He managed to win his first season with a style of play that had never been seen before. He was an innovator and many fans looked forward to his return. Unfortunately, he lost Sandra's trust on night four, aggravated and challenged her to a duel, and the results are now clear for all to see. Listen to this interview to hear how his family reacted to him playing again, details on the tricks he planned to use, what really happened before his final tribal council and lots more! If you enjoyed this interview, check out our others here: SFP Audio Interviews Past SFP Video Interviews Survivor Fans Podcast Homepage Links for Today's Show Tony at CBS Survivor Fever: Survivor Game Changers Contact Info: Voicemail: 206-350-1547 Email: joannandstacyshow@gmail.com Survivor Fans Podcast P.O. Box 2811 Orangevale, CA 95662 Enjoy, Jo Ann and Stacy *Image is copyright and courtesy of CBS
After shaking off the rust and fixing some one-time audio issues, we're back with our pregame draft! Make sure to hit that subscribe button and follow us on Twitter @SurvivorTopTen
We speak to the winner of the 28th season of Cagayan Tony Vlachos about just how close he came to being on another season, why he was the driving force behind several other moves that other contestants were given credit for on air as well as who he gave a fake idol to and why he went online and posted comments on Survivor blogs and websites with fake profiles during the season airing on TV
Warning: We did not edit out profanity in this podcast. If you are offended by profanity, you may want to skip these episodes.
Warning: We did not edit out profanity in this podcast. If you are offended by profanity, you may want to skip these episodes.
D&D sat down with WINNER, Tony Vlachos, and talked about his game from Day 1 to the FINALE. Over three-and-a-half hours of #TeamTV. Survivor Cagayan, Brains, brawn, beauty, survivor28, survivor season 28, Survivor2014, Kass, Jeff Probst, Reality TV, Chaos Kass, SpyShack, Spy Shack, Finale, Interview, Cops R Us, Cagayan, CBS, Survivorcagayan, Tony Vlachos Interview
Today we interviewed Tony Vlachos, winner of Survivor Cagayan. He played the game so hard from day one that many of us were convinced that he was going to burn out before the merge. Instead, he seemed to get stronger as the game progressed, inventing his own rules for how to play, improvising on a level that we have never seen before. Tony will be remembered as one of Survivor's great strategists that was rewarded by a jury that was able to overlook their own bitterness and truly respected his mastery and dominance of the game. Listen to this interview to hear about the early injury that threatened to take him out the game, details on how he destroyed everyone in that mud challenge, the story behind the creation of the spy shack, how he became infected with parasites and much more! If you are not a subscriber to the Survivor Fans Podcast, you can click the Listen Now button on the webpage and the interview will download and play on your computer. If you enjoyed this interview, check out our others here: SFP Audio Interviews Past SFP Video Interviews Survivor Fans Podcast Homepage Links for Today's Show Tony at CBS Survivor Cagayan at Survivor Fever Survivor Links News Archive at Sir Linksalot Contact Info: Voicemail: 206-350-1547 Email: joannandstacyshow@gmail.com Survivor Fans Podcast P.O. Box 2811 Orangevale, CA 95662 Enjoy, Jo Ann and Stacy *Image is copyright and courtesy of CBS
© 2020-2025 Ivy Podcast Discovery LLC
