Podcasts about five dimensions

Did you know that 76% of healthcare tech founders experience burnout while scaling their companies? As leaders in the healthcare tech space generating $2M+ in revenue, focusing on product innovation and market strategy is crucial—but overlooking your personal wellbeing could be the hidden factor preventing your company from scaling effectively.

In today's episode, we are graced with the presence of Dr. Margot McKinnon, a teacher, visionary, and Oxford-educated scholar who inspires people to reconnect with their essence and purpose. Through years of exploration and teaching, Dr. McKinnon has developed a unique five-dimensional model that helps individuals bridge their spiritual and earthly experiences. Her life's work stems from a profound understanding of the spirit, soul, body, mind, and the concept of oneness.The conversation begins with a tale of awakening, as Dr. McKinnon recalls a fasting ceremony that led her to a life-changing spiritual experience. She describes the overwhelming unconditional love she encountered and how it shaped her view of the human experience. “Your spirit is the part of you that came from unconditional love and will return to it,” she shares. This understanding became the cornerstone of her five-dimensional theory, which integrates physical, intellectual, spiritual, soulful, and connective aspects of human existence.We dive deeper into her practical wisdom, as Dr. McKinnon explains how each dimension can manifest in our lives. The body, for example, requires care and respect, from proper nutrition to exercise. The mind thrives on logical systems, while the spirit seeks unconditional love. The soul reveals our purpose, and oneness connects us to the divine and each other. Her anecdotes—from helping students uncover their hidden potential to guiding professionals toward meaningful lives—illustrate how this model serves as a road map for personal growth.Dr. McKinnon's gift lies in making the mystical accessible. She recounts how photographs of our happiest selves can serve as powerful tools for spiritual alignment. One particularly moving story involved a mother who displayed a photo of her son as a joyful child. Within days, he began the arduous journey of overcoming addiction, inspired by the love and light that image represented. This simple yet profound practice reflects her belief in blending spiritual insight with earthly action.The discussion takes a philosophical turn as Dr. McKinnon reflects on society's growing thirst for connection and meaning. She challenges listeners to rekindle their inner essence, comparing it to revisiting a favorite childhood book or memory. “Find your happiest, healthiest self and use that as a compass,” she urges, reminding us that rediscovering joy is often the first step toward transformation.As the episode concludes, Dr. McKinnon invites us to embrace the full spectrum of our humanity. Life, she explains, is about navigating its challenges with grace and learning to ask for help when we need it. "God is very polite," she quips, emphasizing that divine assistance often requires an invitation.SPIRITUAL TAKEAWAYSRediscover Your Blueprint: Use photographs or memories of your happiest, healthiest self as a guide to realign with your true purpose.Embrace Your Dimensions: Cultivate balance across your body, mind, spirit, soul, and oneness to create a harmonious life.Ask and You Shall Receive: Be open to divine guidance by actively asking for help and trusting the process.In this episode, Dr. McKinnon's insights remind us that life is a journey of self-discovery and connection. By honoring each aspect of our being, we create space for growth, fulfillment, and a deeper understanding of the universe's infinite possibilities.Please enjoy my conversation with Dr. Margot McKinnon.Become a supporter of this podcast: https://www.spreaker.com/podcast/next-level-soul-podcast-with-alex-ferrari--4858435/support.

You cannot imagine what God will do in you and through you when you surrender to him and tell him you want to live out his purpose for your life. In this message, Pastor Rick shares the significance of saying these two words to God: “Use me.”

Because God is multidimensional, he doesn't want you to pray one-dimensional prayers. Join Pastor Rick as he helps you discover how praying in five dimensions can awaken your faith and make it personal, passionate, and in partnership with the Holy Spirit. You cannot imagine what God will do in you and through you when you surrender to him and tell him you want to live out his purpose for your life. In this message, Pastor Rick shares the significance of saying these two words to God: Use me. To support this ministry financially, visit: https://www.oneplace.com/donate/1103/29

Because God is multidimensional, he doesn't want you to pray one-dimensional prayers. Join Pastor Rick as he helps you discover how praying in five dimensions can awaken your faith and make it personal, passionate, and in partnership with the Holy Spirit. Do you talk to God like he's your Father? The Bible refers to God as Abba, an intimate word that is similar to Daddy. Join Pastor Rick as he teaches in this message how to pray personal, heartfelt prayers to your heavenly Father. To support this ministry financially, visit: https://www.oneplace.com/donate/1103/29

When you understand how deeply God loves you, it will transform your prayer life. In this message, Pastor Rick shares how God's love and acceptance gives you confidence to approach God and ask him for everything you need in Jesus' name.

Have you ever wondered what prayer accomplishes, what God does with your prayers, or how you should even pray? In this broadcast series, Pastor Rick teaches how to develop an effective prayer life that will transform every area of your life. Because God is multidimensional, he doesn't want you to pray one-dimensional prayers. Join Pastor Rick as he helps you discover how praying in five dimensions can awaken your faith and make it personal, passionate, and in partnership with the Holy Spirit. When you understand how deeply God loves you, it will transform your prayer life. In this message, Pastor Rick shares how God's love and acceptance gives you confidence to approach God and ask him for everything you need in Jesus' name. To support this ministry financially, visit: https://www.oneplace.com/donate/1103/29

As whole human beings, it is vital that we focus and work on all aspects of our health. Join Drs. Scott A. Johnson and Christine Sauer as they explore the keys to enhancing the five dimensions of wellness—physical, mental/emotional, social, spiritual, and financial. --- Support this podcast: https://podcasters.spotify.com/pod/show/scott-a-johnson/support

Episode 203 is about being a man and doing everything possible to lead your family with dignity and honor. In this episode, you'll meet Larry Hagner, the founder of The Dad Edge, an organization dedicated to helping men, husbands, and fathers with the necessary skills to navigate fatherhood.He's also the host of the Dad Edge Podcast and the author of The Dad's Edge and The Spirit of Fatherhood.Larry highlights the five dimensions of being a man: marriage, parenting, leadership, finances, and health. He emphasizes the need for men to learn and implement skills in these areas to create fulfilling relationships and positive memories with their children. He also discusses the impact of generational trauma and the importance of being a pattern breaker, sharing his personal story of overcoming a victim mindset and the power of taking intentional action. If you want to create a stronger bond with your partner and children and build a more solid family foundation, you've got to listen to this episode!Key Takeaways:It is possible to accept limitations without falling into a victim mindset and to maintain positivity in the face of challenges. Taking intentional action and implementing learned skills is key to personal growth and success in all areas of life. Taking small steps and shifting one's mindset can lead to success in various areas of life. Open communication and connection are crucial in maintaining strong relationships, especially in parenting. Creating meaningful conversations with children can strengthen the parent-child bond.More From Larry and The Dad Edge:WebsiteThe Dad Edge PodcastThe Dad's Edge on Amazon The Spirit of Fatherhood on Amazon InstagramFacebookXYouTubeWant To Change Your Life? Check Out FF30X!FF30X is a simple, sustainable, and specific weight loss program designed especially for busy men over 40. With short metabolic training workouts, an easy-to-follow meal plan, and an accountability team there for you every step of the way, FF30X can help you lose weight, regain energy and vitality, and live life to the fullest. Click here to see everything you get when you join FF30X,...

#309 In this episode, Guy talked with Dr. Margot McKinnon. She shared her near-death experience and the framework for spirituality she developed from it, called the Dominance Theory. The episode delves into the five dimensions of self - body, mind, spirit, soul, and oneness. Join the practical discussion on living in the spiritual and earthly plane. The episode also mentioned upcoming retreats in Australia and Croatia. Don't miss out on the transformative insights shared in this captivating episode! About Dr. Margot: Margot McKinnon, PhD, is author of The Exquisiteness of Being Human and The Body, Mind, Spirit, Soul, Oneness Dominance Theory: A guide to elevating your 5 dimensions of self. Being a Spirit Dominant person, Margot needed decades to learn how to be fully human in this Body/Mind Dominant world. For many years, she wanted to ‘go home', back into the unconditional love of the spiritual dimension from where we all have come. She found her Soul purpose as a high school English teacher, helping Spirit Dominant teens create the life their Spirit wanted to live. Margot earned a doctorate from the University of Oxford with a thesis on how to bring spirituality into Canadian schools. She appears on several podcasts such as Next Level Soul, Wisdom from North, and NDE Live. Key Points Discussed:  (00:00) - Dr EXPLAINS The Journey Through Five Dimensions of Self After Her NDE (00:41) - Near-Death Experience and Spiritual Framework (02:17) - Discovering Dr. Margot's Work (03:00) - Explaining Her Profession (03:58) - Connection to Spirit and Early Experiences (06:00) - First Near-Death Experience (09:02) - Impact of Near-Death Experience (12:09) - Fasting Ceremony and Vision Quest (15:09) - Download of the Five Dimensions of Self (19:02) - Explanation of the Five Dimensions (23:12) - Practical Applications of the Five Dimensions (24:42) - Challenges in Spiritual Practices (29:10) - Finding Joy and Self-Discovery (31:09) - Parenting with the Five Dimensions Framework (38:24) - Grounding Children and Spirit (46:32) - Creating the Garden of Eden (52:16) - Spirit-Dominant Leadership Movement How to Contact Dr. Margot McKinnon:www.drmargotmckinnon.com   About me:My Instagram: www.instagram.com/guyhlawrence/?hl=en Guy's websites:www.guylawrence.com.au www.liveinflow.co''

Andy Ivanovich, the CFO of The Knot, joins CJ to dissect the company's business model. He sheds light on how The Knot, which functions like an operating system for weddings, has grown to expand its product suite and reach, and now touches two-thirds of adult Americans each year. Andy explains the five dimensions of the company's transactions that make it so unique. He also sheds light on The Knot's ICP (Ideal Customer Profile) and customer LTV (Lifetime Value), and how they optimize for a supplier's lifetime value through their subscription model. He sheds light on some M&A wisdom, explaining the Build, Buy, or Buddy framework for a roadmap expansion, and why “burning the lifeboats” is necessary for fully committing to change. Tuning in, you'll hear about the CFO's job of “truth-seeking”, why your team should be encouraged to challenge conventional wisdom, and how to manage a healthy level of friction amongst your peers.If you're looking for an ERP head to NetSuite: https://netsuite.com/metrics and get a customized KPI checklist.—SPONSORS:Mercury is the fintech ambitious companies use for banking and all their financial workflows. With a powerful bank account at the center of their operations, companies can make better financial decisions and ensure that every dollar spent aligns with company priorities. That's why over 100K startups choose Mercury to confidently run all their financial operations with the precision, control, and focus they need to operate at their best. Learn more at mercury.com.Mercury is a financial technology company, not a bank. Banking services provided by Choice Financial Group and Evolve Bank & Trust®; Members FDIC.NetSuite provides financial software for all your business needs. More than 37,000 thousand companies have already upgraded to NetSuite, gaining visibility and control over their financials, inventory, HR, eCommerce, and more. If you're looking for an ERP platform ✅ NetSuite: https://netsuite.com/metrics and get a customized KPI checklist. Maxio is the only billing and financial operations platform that was purpose built for B2B SaaS. They're helping SaaS finance teams automate billing and revenue recognition, manage collections and payments, and put together investor grade reporting packages.

This episode is supported by the University of Warwick's Centre for Teacher Education. Click here to learn more.In this episode, we unpack the nuanced role of middle leaders with Liz Benson. Liz, a visionary in the field with over two decades of experience, discusses the evolution of middle leadership, its complexities, and the need to celebrate its unique significance. Tune in to discover actionable strategies for bolstering middle leaders, learn about the five dimensions of Trust from Griffith University's research, and recognise the potency of advocacy and influence within your team. Episode Overview- Liz Benson's insights on middle leadership and the launch of her new book.- Understanding Middle Leadership Contexts — Liz emphasizes the crucial role of middle leaders and the senior leadership's responsibility to nurture them.- Practical Development Steps for Middle Leaders — On-the-job learning and the benefit of mutual accountability.- Cultural Transformation Through Conversations — The value of coaching and fostering a solid research foundation.- Networking and Professional Growth — Liz advocates for middle leaders extending their influence beyond their own schools.- Middle Leadership Agency — Shane and Liz talk about empowering middle leaders to enhance recruitment and retention of quality educators.- Trust and Influence — Exploring the specific skills needed by middle leaders and the research backing their importance.- Amplifying Middle Leaders — Liz discusses her efforts in elevating middle leader voices through multiple platforms.- A reflection on the importance of middle leadership and the shift in how their roles are perceived and valued. Resources- Liz Benson's Book, "Middle Leadership in Schools"- Griffith University Research on the Five Dimensions of Trust Thank you for tuning in, and as always, if you found this episode useful, please share your experience. You can find me online on X (@leaningshane), and LinkedIn. My website is shaneleaning.com. About the hostShane Leaning is a passionate organisational development coach with over 14 years of international teaching and leadership experience. His approach to coaching and professional development is all about approachability and attentiveness to the unique strengths and contexts of schools and educators. Shane believes that empowerment fosters growth and success for both educators and students alike.

This is part of a leadership lecture (delivered on 28, January 2024). It looks at the idea of religiousness of marital leadership in five ways: faith, devotion, experiential comprehension, consequential considerations, and deep knowledge. Listen, learn, and laugh as you edit your Youniverse! For more lectures and counseling services, visit: www.abdulfattahadeyemi.com

In this episode, Corbin and Dr. Armstrong discuss the five dimensions of wellness—what Dr. Armstrong refers to as “well-centered fitness.” The hosts discuss the importance of incorporating Spiritual, Physical, Intellectual, Emotional, and Social wellness in our daily lives. “Fitness” refers to something that one improves over time and can be defined as a state of physical and mental well-being that allows an individual to perform daily activities with vigor and without undue fatigue. “Well-centered fitness” is discussed as a mindset and a continuous journey requiring regular physical activity, healthy lifestyle choices, and a positive mindset to achieve and maintain optimal health and wellness and to… age well.In this episode, Dr. Armstrong refers to InSideOut Coaching by Joe Ehrmann. This is a book about “transformational” v. “transactional” coaching, but it is equally relevant for those of us who are “self-coaching” and seek to… age well.Support the showHave questions you want answered and topics you want discussed on "Aging Well"? Send us an email at agingwell.podcast@gmail.com or record your question for us to use in an upcoming episode:https://www.speakpipe.com/AgingWellPodcast

In this HCI Podcast episode, Dr. Jonathan H. Westover's AI assistant, Charlotte, shares his recent Human Capital Leadership article, "Five Dimensions of Company Culture and How to Navigate Them." Read the full article here: https://www.innovativehumancapital.com/post/five-dimensions-of-company-culture-and-how-to-navigate-them. From the conclusion: "Understanding company culture is essential for anyone starting a new job. By gaining a clear understanding of the five key dimensions of company culture, you can adapt to your new work environment and be more effective in your role. Whether it's through asking questions, observing your colleagues, being open-minded and adaptable, or seeking feedback, there are many ways to develop a clear understanding of the company culture. By taking the time to do so, you can build stronger relationships with your colleagues, navigate changes more effectively, and contribute to the company's success." Part of the LinkedIn Podcast Network #LinkedInPresents Further explore the topics discussed in this episode with the new HCIConsulting Chatbot: https://poe.com/HCIConsulting. Please consider supporting the podcast on Patreon and leaving a review wherever you listen to your podcasts! Check out Factor at www.factormeals.com/HCI50 and use code hci50 to get 50% off your first box! Check out Manifest at at https://bit.ly/manifesthci. Check out CrowdHealth and start your free trial at joincrowdhealth.com and use promo code HCI. Check out the HCI Academy: Courses, Micro-Credentials, and Certificates to Upskill and Reskill for the Future of Work! Check out the LinkedIn Alchemizing Human Capital Newsletter. Check out Dr. Westover's book, The Future Leader. Check out Dr. Westover's book, 'Bluer than Indigo' Leadership. Check out Dr. Westover's book, The Alchemy of Truly Remarkable Leadership. Check out the latest issue of the Human Capital Leadership magazine. Each HCI Podcast episode (Program, ID No. 627454) has been approved for 0.50 HR (General) recertification credit hours toward aPHR™, aPHRi™, PHR®, PHRca®, SPHR®, GPHR®, PHRi™ and SPHRi™ recertification through HR Certification Institute® (HRCI®). Each HCI Podcast episode (Program ID: 24-DP529) has been approved for 0.50 HR (General) SHRM Professional Development Credits (PDCs) for SHRM-CP and SHRM-SCPHR recertification through SHRM, as part of the knowledge and competency programs related to the SHRM Body of Applied Skills and Knowledge™ (the SHRM BASK™). Human Capital Innovations has been pre-approved by the ATD Certification Institute to offer educational programs that can be used towards initial eligibility and recertification of the Certified Professional in Talent Development (CPTD) and Associate Professional in Talent Development (APTD) credentials. Each HCI Podcast episode qualifies for a maximum of 0.50 points. Learn more about your ad choices. Visit megaphone.fm/adchoices

TOPIC TIME CODES 0:42 – Introduction 1:50 – Ellen 3:12 – Dominique 5:55 – Origin Story 8:50 – Swiss Secrets 13:20 – The Five Dimensions 13:45 – The Intellectual Dimension 16:00 - The Physical Dimension 18:40 – Keys to Happiness 19:53 - The Emotional Dimension 22:35 - The Spiritual Dimension 26:10 - The Financial Dimension 29:10 – The Happiness Index 31:20 – 50+ Entrepreneurship 33:33 – How Gears Interact 36:00 – Insights About Ellen & Dominique 39:00 – Insights to Live By 44:10 - Parting Thoughts and Resources SOURCES: https://www.wakeupshakeupthrive.com/ whealthness.ch (Ellen)https://www.linkedin.com/in/ellenkocherwhealthness/ pointnorth.biz (Dominique)https://www.linkedin.com/in/dominiquebendhaou/  Resource Hub Freebies:  https://www.wakeupshakeupthrive.com/resources/Use CODE ICARE for COST-FREE THRIVE GUIDE ALIVE VIDEO SERIES: https://www.wakeupshakeupthrive.com/thrive-guide-alive/ BONUS CONTENT:Our Top 10 Ways to Have More Fun: 1) Set the goal of playing more. After all, what's the point of setting a goal like being thin, having more money or having your own busi­ness if you're not enjoying yourself?  2) Decide what fun means for you by making a list of things that you enjoyed doing as a kid. Go over your list and highlight what still sounds appealing. Then explore what you want to try!  3) Schedule time to play in your agenda, because if you don't schedule it, it's unlikely to happen.  4) Create a play drawer for those times when you need a break from life or work, and you just want to be silly. You might include puz­zles, board games, coloring books, Lego's — whatever inspires you!  5) Combine fun with other activities. Think of the things on your to-do list and then look for ways to combine them to make them more fun.   6) Have more fun at work. Brainstorm with colleagues how you can bring more fun and humor into the workplace.  7) Make playdates with your significant other to strengthen your relationship and keep playfulness alive.  8) Befriend a fun person because the people you relate with will have an enormous impact on your life.  9) Hang out with kids who innately know how to play and have fun.  10) Add creativity to daily activities such as singing while you cook or dancing while brushing your teeth.

For this week, we have the impressive Celia Sandhya Daniels from India to talk about their career and passion to educate, empower, and advocate for gender-expansive individuals in the community and corporate world.  This is PART one of a three-part piece.Trigger Warning: Sexual assault, Child abuse, Violence, Transphobia, Homophobia, Gender Dysphoria, Suicidal ideationWe dive into Celia's life in five dimensions, Dreaming, Doubt, Denial, Discovery, and Destiny. Firstly, Celia as a child dreamt to be a girl. However, as she was growing up the fear of being bullied forced them to hide their identity. Celia reveals the sexual abuse she encountered and the shame, fear, and trauma she faced alone. We learn of Celia's doubts about her being a trans-lesbian and violence in 9th grade that is commonly practiced in India. This traumatic experience led Celia to struggle with living and in denial of her existence. Once married, Celia had assumed that being with a wife would somehow "fix" her. Celia eventually began attending therapy where there was a  lack of knowledge on transgender identity. Later she began to discover herself while struggling with gender dysphoria. Today, she is open with her family and finds acceptance. Lastly, Celia shares her destiny, which is to advocate and educate across the world, for an LGBTQIA+ community that holds itself with pride and dignity, where one is valued and has credibility in what they do and speak. The conversation turns to healing from trauma. Celia mentions how the film “Spotlight” and Amita's project “Mirror Memoirs” of LGBTQ survivors of color in the movement to end child sexual abuse gave them the courage to speak out.  In our next episode, Celia will share her success in a long-lasting 26-year marriage.  Stay tuned!  ~~~Celia Sandhya Daniels (She/They) is an entrepreneur, motivational speaker, D&I champion, blogger, composer, musician, photographer, hiker, and filmmaker. She currently resides in southern California with her family. She is an Asian Indian who identifies as gender non-binary, trans fem. Ceila is a management consultant with over 20+ years of success in media, health care, and life science engagements for over 100 companies. Ceila has received several awards such as the 2019 human rights campaign equality award for outstanding commitment and service to the community, the social justice award, and so on. You can follow or contact Ceila below; Website: https://www.rebekon.com  Email: celia@rebekon.com Mentioned in this podcast;  Amita Swadhin ~ https://mirrormemoirs.com/about-the-founder/  Movie, Spotlight ~ https://www.imdb.com/title/tt1895587/ Support the showBreakfast With Tiffany Show Official Facebook Page ~ https://www.facebook.com/breakfastwithtiffanyshow Tiffany's Instagram Account ~ https://www.instagram.com/tiffanyrossdaleofficial/ For coaching sessions & programs with Tiffany, check out her official page ~ https://www.tiffanyrossdale.com Breakfast With Tiffany Show Youtube Channel ~ https://bit.ly/3vIVzhE Breakfast With Tiffany Show Official Page ~ https://www.tiffanyrossdale.com/podcast For questions, requests, collaborations and comments, feel free to reach us via our e-mail~breakfastwithtiffanyshow@outlook.com

In this episode we have founder and creator of Inner Workout Taylor Elyse Morrison. We explore diverse self-care practices that can support you in overcoming burnout and stress and coming back into your body. Taylor guides us on The Five Dimensions of Well-Being Framework and how we can explore physical, energetic, mental + emotional, wisdom & bliss as pathways to relax and nourish our systems. Taylor Elyse Morrison is an author, facilitator, and coach making well-being and personal development more accessible. Through her company Inner Workout and her book of the same name, Taylor supports people's journey to know, care for, and become their full selves. Inner Workout Book Taylor's Instagram Inner Workout's Instagram

What is the nature of the universe we live in? Nobel-winning scientists seem to believe that our universe is not real, not local, and it is a projection, getting its information from an outside source. Could it be the case? And what does it mean for us? How can we benefit from this?In this episode, I answer these questions and more.For more content, please visit @paradigm.shift.experience on Instagram.To support the show, please visit my merchandise store at https://bit.ly/3OqA90dBuy me Coffee at https://www.buymeacoffee.com/sergiohalabiSupport the show

Presence & Realness: Five dimensions of finding liberation through living. 1. Rebirthing —life within life  2. Bhavana —beautification of mind 3. Parami —states of excellence  4. Ubuntufiction-Bodhisattva —prioritizing shared space as nexus of liberation   5. Nibbanafication —unconditional engagement to keep liberating freedom  Maui Series #5 6.30.21 Alan Clements

In what way does the flood in the time of Noah prefigure baptism? Is baptismal water magically regenerative? Why would a robe be baptized in blood and how does it fit our study? On today's episode of the After Class Podcast, Sam, Ron, and John conclude their reading of the Bible's passages on baptism and present the five dimensions of baptism that have emerged from our study.

What is the nature of God? How do we define the relationship between Creator and Creation? Are religious beliefs grounded in reality, or is there a deeper connection?In this episode, I answer these questions and more.For more content, please visit @paradigm.shift.experience on Instagram.To support the show, please visit my merchandise store at https://bit.ly/3OqA90d Support the show

In this episode, our hosts breakdown the 5 Dimensions of Touch, from an article written by renowned sex therapist Barry McCarthy, PhD. George and Laurie guide us through the different dimensions: Affectionate touch, sensual touch, playful touch, erotic touch and intercourse. These 5 dimensions are NOT a linear roadmap to intercourse rather ways to increase touch between couples. Hosts provide examples of each and make it possible for couples to explore different levels and kinds of touch and how to have those important conversations to share what feels good, and what doesn't with your partner. You can check out the original article here:  http://bit.ly/3V7rCD8 and make sure to download the episode for more! Check out our sponsors and support the podcast! ZocDoc is a free app to help you find a medical professional when you need one. Use the link so they know we sent you! Uberlube is our favorite lubricant and they've supported our podcast from the start. Laurie has been recommending this for 20 years, long before Foreplay started. Check them out! Use the coupon 'Foreplay' for a discount! Learn more about your ad choices. Visit megaphone.fm/adchoices

Preached at The Lighthouse Chapel International, Prince Of Peace Cathedral

Happy October everyone! All month long we will be clarifying and honing in on some of Inner Workout's core concepts. In this specific episode of Inner Workout, Taylor teaches on the five dimensions of wellbeing : the physical, the energetic, the mental & emotional, the wisdom and the bliss dimensions. Get ready to learn and ponder some deep questions! Inner Circle : innerworkout.co/inner-circleShow Notes:  innerworkout.co/post/what-are-the-five-dimensions-of-well-beingFree Self-Care Assessment: innerworkout.co/take-care-profileNewsletter: innerworkout.co/self-care-sundaysInstagram: @innerworkout | @taylorelysemorrison

If I were ever granted a do-over, one thing I would do differently is to take my well-being seriously.Sadly, my well-being did not show up on my list of priorities when I was in my 20s, 30s, or even early 40s. In fact, I had previously confessed that the stupidest thing I ever said was, “I'll sleep when I'm dead.Thankfully, some level of wisdom prevailed and I no longer think that way. Somewhere along the way, I learned the importance of self-care and about putting my well-being on my list of prioritiesThat's why I'm so excited to host this conversation with Ellen Kocher and Dominique Ben Dhaou here on the podcast.Ellen and Dominique are the powerhouse duo behind Wake-Up, Shake Up, Thrive and the co-authors of the book, “Wake-Up, Shake-Up, Thrive! How to Lift Up your Life in Your 50's and Beyond”Ellen and Dominique met at a conference where Dominique was a featured speaker. They hit it off, with their mutual love of good food and fine wine, and most importantly, their passion for supporting individuals and organizations to conquer age 50+ demographic challenges.In this episode, Dominique and Ellen gave me a preview of their book and walked me through the five dimensions of well-being in midlife and beyond.ABOUT MY GUESTS:Dominique Ben Dhaou is a Swiss National who has been working in Human Resources leadership roles in international organizations for over 30 years. She has experience in 12 different industries across continents. As the Founder and Managing Director of PointNorth International, she helps professionals and executives reinvent a career that truly fits their experience, values, skills and purpose. Her passion for untapped potential goes far beyond conventional human resources practices.Dominique's co-founder for Wake Up, Shake Up, Thrive is Ellen Kocher. Ellen completed her undergraduate work in Economics and Finance and began her career as a Management Consultant. As a seasoned executive and senior manager, she faced the challenges of a busy working lifestyle, sprinting between responsibilities, deadlines, and travel. In 2003, Ellen decided to slow down her hectic job to care for her three children, giving her the opportunity to reassess her career-driven lifestyle. She lost weight and discovered her best new self through nutrition and lifestyle change. DISCUSSED IN THIS EPISODE: Why it's important to think of these dimensions as gears The five dimensions of well-being: physical, emotional, intellectual, financial and spiritual Quick actionable steps to incorporate these dimensions into our lives today Why it's literally “never too late” to start For all the links and show notes, head on over to http://secondbreaks.com

Is your idea of an ideal evening a nice meal at home and a book or a Netflix queue?    Or would you rather be at a cocktail party with people from all walks of life exchanging stories or jumping up and down to a throbbing beat in the middle of a crowded dance floor?    How you answer this question is one of many ways that you can explore your personality type. The personality you have will help you determine how to leverage your strengths (and confront your “opportunities”) on your path to success.    Psychology research determined that there are common areas of personality that all people share with many characteristics that fall under them. They are the Big Five Personality Dimensions and they might be useful to you on a journey of self-discovery.    In this episode, we explore the Big Five Personality Dimensions and how they might affect your preferences. We also look at the characteristics that fall under those dimensions to determine how these facets can affect our choices.      Key Ideas to Improve your Customer Experience   The Big Five Personality Dimensions are the areas of our personality that drive our decisions. They include Conscientiousness, Extroversion, Agreeableness, Neuroticism, and Openness. For each dimension, there are personality traits that are associated with the area. For example, Extroversion, which determines how you generate your energy around (or away from) people, has facets like warmth, assertiveness, and excitement seeking, as a few of them. We think taking an online quiz is a great start in a journey of exploration for better self-awareness, as well as understanding the people around you.    Here are a few key moments in the discussion:   05:00   Ryan shares his insight on the differences between the two personality camps for psychological research and how it relates to the Big Five Personality Dimensions. 11:32   We discuss some of the psychology tests that human resources departments often use and how we think they should be applied to a journey of self-awareness and discovery.  17:05  We cover the Five Dimensions of Personality and explain what they are, as well as the characteristics associated with each area. 24:26  Colin shares a story about how a leadership conference revealed to him several years ago how his personality traits were interpreted by his team through communication, and how they didn't necessarily match his self-view.  27:50   We share the practical applications we see for personality exploration in customer experience, customer strategy, and personal self-discovery.        Please tell us how we are doing! Complete this short survey.    Customer Experience Information & Resources   LinkedIn recognizes Colin Shaw as one of the 'World's Top 150 Business Influencers.' As a result, he has 290,000 followers of his work. Shaw is Founder and CEO of Beyond Philosophy LLC, which helps organizations unlock growth by discovering customers' hidden, unmet needs that drive value ($). The Financial Times selected Beyond Philosophy as one of the best management consultancies for the last four years in a row. Follow Colin on LinkedIn and Twitter.   Click here to learn more about Professor Ryan Hamilton of Emory University.    Why Customers Buy: As an official "Influencer" on LinkedIn, Colin writes a regular newsletter on all things Customer Experience. Click here to join the other 35,000 subscribers.    How can we help? Click here to learn more about Beyond Philosophy's Suite of Services.

This week, please join author Ronald Goldberg, Editorialist Hertzel Gerstein, and Guest Editor Rury Holman as we discuss the article "Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study" and the editorial "Shouldn't Preventing Type 2 Diabetes Also Prevent Its Long-Term Consequences?" Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-host. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Centre and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Today. Oh, this feature discussion involves the glance of diabetes. Truly this interview, I felt like I was sitting among gurus and just learning so much about diabetes, the history and the whole topic is about long term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program and its outcome study. Now, way more than that, we discussed. You have to have to listen. But okay, before that, let's summarize today's issue for our listeners. Shall we, Greg? Dr. Greg Hundley: You bet Carolyn. So the first paper that I've got to discuss today really comes to us from the world of interventional cardiology and it's led by Dr. William Fearon from Stanford University Medical Center. Well, Carolyn previous studies have shown quality of life improves after coronary artery revascularization, more so after coronary artery bypass grafting than after PCI. Now this study aimed to evaluate the impact of fractional flow reserve guidance, and current generation zotarolimus drug-eluting stents on quality of life after PCI compared with CABG. Dr. Greg Hundley: Now the study emanates from fractional flow reserve versus angiography for multi vessel evaluation or the fame three trial. And Carolyn, that's a multicenter international trial that included 1500 patients with three vessel coronary artery disease who were randomly assigned to either CABG or FFR guided PCI. Now, what did they assess? So quality of life was measured using the European Quality of life Five Dimensions. And we're going to abbreviate that EQ-5D questionnaire baseline, one, and then 12 months following the procedure. Also, Canadian cardiovascular class angina grade and working status were assessed at the same time points, and then also an additional time point in six months. And the primary objective was to compare the EQ-5D summary index at 12 months, and secondary endpoints included angina grade and work status. Dr. Carolyn Lam: Ooh, interesting Greg. So quality of life in the theme three trial. All right. So what did they find? Dr. Greg Hundley: Right, Carolyn. So the EQ-5D, so that... European Quality of life Five Dimensions summary index at 12 months did not differ between the PCI and CABG groups, but the trajectory over the 12 months at the one month time interval between PCI and CABG did differ. Now, the proportion of patients with the Canadian cardiovascular class or CCS2 or greater angina 12 months was 6.2% versus 3.1% respectively in the PCI group compared with the CABG group. Additionally, a greater percentage of younger patients, so those less than 65 years old were working at 12 months in the PCI group compared with the CABG group. So in summary, Carolyn, in the fame three trial, quality of life after fractional flow reserve guided PCI with current generation DS compared with CABG was similar in one year. And the rate of significant angina was low in both groups and not significantly different. However, the trajectory of improvement in quality of life was significantly better with PCI as was working status in those less than 65 years old. Dr. Carolyn Lam: Wow. Thanks Greg. Hey, guess what? It's time for Greg quiz. The next paper is about the Chocolate Touch Study. So, Greg, is this about, A, the benefits of eating chocolate? B, the benefits of chocolate mud baths? Or C, the benefits of a second generation drug coated balloon? Dr. Greg Hundley: So, Carolyn, I just have one question. Where in the world do we get the benefits of chocolate mud bath? I don't think that's right. I do love eating chocolate, but I am going to go with the benefits of the second generation drug coated balloon. Dr. Carolyn Lam: Yeah, yeah, yeah. I made it easy for you. All right. So first generation drug coated balloons have significantly reduced the rate of restenosis compared to balloon angioplasty alone. However, high rates of bailout stenting and dissections persist. The chocolate touch drug coated balloon is a nitinol constrained balloon designed to reduce acute vessel trauma and inhibit neointima formation and restenosis, so you were right, Greg. In today's study led by Dr. Shishehbor, from University Hospital's Harrington Heart and Vascular Institute at Cleveland, Ohio. They studied 313 patients with claudication or ischemic rest pain, and superficial femoral or popliteal disease. And randomized them one to one to the chocolate touch or Lutonix Drug Coated Balloon at 34 sites in the United States, Europe and New Zealand. The primary efficacy endpoint was drug coated balloon success defined as primary patency at 12 months. The primary safety endpoint was freedom from major adverse events at 12 months. A composite of target limb related death, major amputations, or reintervention. Both primary endpoints was assessed for non-inferiority and have met sequential superiority testing for efficacy was pre-specified. Dr. Greg Hundley: Interesting, Carolyn. So this nitinol constrained balloon designed to reduce acute vessel trauma. So, what were the results of this study? Dr. Carolyn Lam: So in this trial, the second generation chocolate touch drug coated balloon met both non-inferiority endpoints for efficacy and safety. And was more effective than the Lutonix Drug Coated Balloon at 12 months for the treatment of femoral popliteal disease. Cool, huh? Dr. Greg Hundley: Very interesting. Great summary, Carolyn. So Carolyn, my next paper comes to us from the world of preclinical science. And the impact of three dimensional chromatin topology on transcriptional dysregulation and pathogenesis in human dilated cardiomyopathy remains elusive. And so these authors led by Professor Lei Jiang from Guangdong Provincial People's Hospital, and Guangdong Academy of Medical Science, generated a compendium of 3D epigenome and transcriptome maps from 101 biobank human dilated cardiomyopathy, and non-filing heart tissues and mouse models to further interrogate the key transcription factor implicated in 3D chromatin organization, and transcriptional regulation in dilated cardiomyopathy pathogenesis. Dr. Carolyn Lam: Oh, wow. Sounds like a lot of work. What did they find, Greg? Dr. Greg Hundley: Right, Carolyn. So they found that enhancer promoter connectomes are extensively rewired in human dilated cardiomyopathy, which reside in pre accessible chromatin size and also hand one drives the rewiring of enhancer promoter connectome to induce dilated cardiomyopathy pathogenesis. Dr. Carolyn Lam: Okay, Greg. So what are the clinical implications? Dr. Greg Hundley: Right, Carolyn. So first, dilated cardiomyopathy enriched enhancer promoter loops identified in this study could be developed as novel 3D genomic biomarkers for dilated cardiomyopathy. And then second Carolyn, targeting hand one might be used as a novel approach for therapeutic intervention in patients with dilated cardiomyopathy. Dr. Carolyn Lam: Oh, nice. Greg. Well, also in today's issue, there's an On My Mind paper by Dr. Brook, entitled, “The Doctor is Out, New Tactics and Soldiers For our Losing Battle against Hypertension.” In another paper, we have Molly Klemarczyk bringing us highlights from the Circulation Family of Journals. Dr. Greg Hundley: Right, Carolyn. And also from the mailbag, there's a Research Letter from Professor Baggish, entitled, “Cardiovascular Outcomes in Collegiate Athletes, Following SARS-CoV-2 Infection: The 1-Year Follow Up From the Outcomes Registry for Cardiac Condition in Athletes.” Well, Carolyn, how about now we get onto that feature discussion and learn a little bit more about the long term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program. Dr. Carolyn Lam: Hold on to your seats, everyone. Here we go. We know that lifestyle intervention and metformin have been shown to prevent diabetes. However, what is their efficacy in preventing the cardiovascular disease associated with diabetes development? Well, guess what? We're going to have data on that through today's feature paper and what a star crowd I'm talking to today. We have Dr. Ron Goldberg and he's a first end corresponding author from the University of Miami Diabetes Research Institute. We have the editorialist Dr. Hertzel Gerstein from McMaster University Population Health Research Institute. And a guest editor for this paper, Dr. Rury Holman from University of Oxford. I have to admit I'm starstruck. You gentlemen have totally defined the field. I cannot wait to learn more, but shall we start with you, Dr. Goldberg? Could you tell us a little bit more about your paper, what you did, what'd you found? Dr. Ronald Goldberg: So the background is that the Diabetes Prevention Program started in 1996 was a Diabetes Prevention Program to test the effects of intensive lifestyle intervention versus metformin, versus placebo on the prevention of diabetes in over 3000 individuals with impaired glucose tolerance, a form of prediabetes. And after demonstrating the efficacy of those interventions over about three years, we went on to do a follow up study in which the metformin group continued to receive it. Everybody got lifestyle because it worked so effectively. And we are now reporting after a further 18 years of follow up on the question of whether these interventions, now 21 years later, had any effect on cardiovascular outcomes. The background to that of course, is that people with prediabetes have a somewhat increased risk for heart disease and that rate increases as diabetes develops, particularly with severity of hyperglycemia and duration of diabetes. So, that was the study and we're now reporting on whether these interventions had a significant effect on the major cardiovascular. Dr. Carolyn Lam: Well, first Dr. Goldberg, congratulations on the foresight to get the informed consent and to plan ahead to be able to get these valuable data. But because I know this is going to be a critical point later. Could you tell us a little bit about the completeness of follow up and perhaps surveillance for outcomes before you share the results? Dr. Ronald Goldberg: Absolutely. So, 86% of the original randomized group of participants agreed to continue with a follow up study, so there was a loss at that point. And then of course, over 18 years of follow up, there's going to be a further loss. Some due to death and some due to loss to follow up. But despite that, I would say the group that entered the follow up study, we were able to maintain follow up in 85%. Dr. Carolyn Lam: Fantastic. And the results? Dr. Ronald Goldberg: The findings were that we found no significant effect of either of the two active interventions on our primary cardiovascular outcome, which was nonfatal myocardial infarction, stroke and fatal cardiovascular disease. We also had an extended outcome with more events in it, and similarly found no significant benefit or harm from either of those two intervention. Dr. Carolyn Lam: Oh, I love that paper. What a great, great, perhaps surprising conclusion that Dr. Gerstein loved the title of your editorial, you crystallize it. Shouldn't preventing type two diabetes also prevent long term consequences? So please tell us what was your thoughts when you saw this paper and how you frame it? Dr. Hertzel Gerstein: Thanks very much, Carolyn. And first of all, I was very impressed by the extensive amount of work and analysis done by Dr. Goldberg and his team. I thought that it's wonderful to see this sort of long term follow up. I've had the privilege in the past of speaking together with the DPP team on their trial and in their long term follow up. And I continue to be impressed by the extensive amounts of work and data collected and a rigor and academic value of the analysis. So, that was my very first impression and obviously it's a pleasure to write on this. I think the findings are clearly important and they both highlight the importance of long-term follow up as well as highlight the difficulties of long-term follow up in a study like this. Dr. Hertzel Gerstein: So this was a study done in a trial, originally done in a fairly young cohort of individuals who had very low risk for cardiovascular events. And over their 18 year follow up that Dr. Goldberg Ron described, the actual annual event rate for the primary outcome was 0.6% per year in that ballpark. Now, anybody... I've had the privilege as Ron Avery of doing many cardiovascular trials and we all know that we would never start a trial recruiting people with an event rate of 0.5% per year, 0.6% per year, because we would have to recruit 30,000 people and follow them for seven years in order to accrue enough events to be able to detect a clinically relevant benefit of the therapy. So because of this low event rate, the advantage was the long term follow up, the 26th year, I think it was in the end follow up. No, it was a 21 year median follow up period, because of the long follow up, you get a little bit away from the advantage of the low event rate. Dr. Hertzel Gerstein: But even then, over the course of the 21 years, there were only about 310 first cardiovascular events and most cardiovascular outcomes trials, for instance, we need close to at least a 1000, 500 to a 1000 is what we like to see. So that being said, it's perhaps not surprising that we didn't see a benefit of diabetes prevention because even if diabetes reduces the risk of a cardiovascular event by a quarter, by 25%, there would've only been a 50, 50 chance of detecting that with this particular cohort of people. Dr. Hertzel Gerstein: So I would say that the most conservative assumption is that diabetes prevention doesn't reduce the event rate by 25% or less or 30, but it's certainly... pardon me, by 25% or more, it could reduce it by 20%, 15% we would not have detected at all, or Ron would not have detected and his team would not have detected it with this thing. So I think that to me is the most important caveat in interpreting this does not mean that diabetes prevention has no effect on cardiovascular outcomes. Dr. Hertzel Gerstein: It means that diabetes prevention doesn't have a moderate or smaller effect. So, that's I think the most important message to take and as is even mentioned in the paper by Ron and the team is that there has been at least one diabetes prevention trial conducted in China many, many years ago that showed clearly that people who were randomly assigned to the diabetes prevention arm, 26 years later did have lower cardiovascular events and even death than people who were in the control arm. So, I think this adds to the story but it's clearly like everything, not the final word in this, but it certainly adds a lot of important data. Dr. Carolyn Lam: Oh, I would love to hear Dr. Goldberg's response to that. But before that, Dr. Holman, could I ask you to weigh in as well? Dr. Rury Holman: Yes. Sure. So, I agree with Hertzel that this is underpowered, but this is a question I've long wanted to see the answer to. And I congratulate Ron and his team for actually doing the work. All major studies should have long term follow up. People should be consented for life so that we can answer these questions. And Hertzel even though the power is perhaps minimal, we still need to do this analysis. Dr. Rury Holman: And if there had been a dramatic result, then we'd have all been very excited. I think one of the issues... one, if I could just bring it up, you mentioned the look ahead study in your discussion as being a negative dietary intervention. But I have a slightly different take on that. When you look at that paper in detail, what you see is that the people in the usual care group forgot quite a lot more risk factor reduction medications, and that's because their usual care physicians spotted the fact that their risk factor levels were higher than in the intensive care group, of course it was blinded at that point. But there's a whole point here is, in your paper you show an increase in the statin proportion, which is higher in the placebo group compared with the metformin and your intensive lifestyle, significantly so for the lifestyle one. So I'm just wondering whether even the low power was further blunted by the drop in effects of these other medications. Dr. Ronald Goldberg: Thanks very much for those comments guys, I think they're spot on. Let me first respond Hertzel with my thoughts on this, and then go over to your point, Rury. I think it's really interesting to look back over time and realize how much medical management has changed. And that goes right to your point, Rury, that doing a clinical trial like this where the primary care physicians are informed about what we're doing, what... communicated with on a regular basis, particularly when their patients develop diabetes, it just heightens the entire level of medical management. And I think you're absolutely right, but it's interesting to see what's happened to cardiovascular disease over the last 25 years, both in the general population and in the prediabetic population, the risk of cardiovascular disease has gone down. And then on top of that, we've got this very intensive cardio prevention intervention by primary care physicians, with high rates of statin usage, high rates of any hypertensive treatment, even the placebo group to your question, really lost weight. Dr. Ronald Goldberg: And they knew full well what was... and this was a very hands on type of study where our participants were really followed now for all these years, really became integrated with the research team. And so everybody knew what everybody else was doing. And so I'm sure the placebo effect was very strong, but I think nevertheless... Oh, and the last point I wanted to make was of course, the severity of the diabetes, even though 60% are developed diabetes, the severity of the diabetes was relatively mild. Even in those who developed diabetes, we know their average A1C was only about 6.7. And so I think that has a lot to do with blunting the acceleration effect of diabetes on cardiovascular disease. So, I think all of these factors contributed together to produce a negative result. But I think an important message, nevertheless. Dr. Hertzel Gerstein: I can highlight that point, that Ron was saying is that if diabetes prevention is going to prevent cardiovascular outcomes, it's going to do that because of a difference in glycemic exposure. The diabetes is by definition a disease of an elevated blood sugar. So if diabetes prevention prevents cardio, it means that the blood sugar's going to be lower than it would otherwise be. So if there's very little difference over the long term follow up in blood sugar because of co-intervention and therapy of all the treatment groups, then that would eliminate a lot of the benefits of diabetes prevention, because these are patients who are in this trial, who are being scrutinized even more than they would be if they were out there free range without being involved in any follow up. So, that's a spot on point. Rury, you wanted to comment. Dr. Rury Holman: Yeah. So, Hertzel just to expand on that. Obviously the glycemic impact on macrovascular disease is relatively modest compared to the impact on microvascular disease, which of course is what we all saw originally with type 2 diabetes. In fact, in KPDS35, when we looked or calculated what 1% reduction in A1C would do, it would only reduce stroke or MI by about 12 to 14%. So it's quite a shallow slope if you like. And your point is spot on is if that glucose levels are kept low by good treatment and good management role tell us about the great team they have. Then there was no room for a glycemic impact in this particular study. It's another question, whether you think metformin acts by different mechanisms to reduce cardiovascular disease, that's another question I had for Ron that he might like to address, is if there was a magic effect of metformin, why didn't we see that? Dr. Ronald Goldberg: And that's a really interesting question, Rury, because you may be aware that we published a paper a few years ago on our assessment of coronary calcification in a subgroup, in about 60% of the population who agreed to do this and who were eligible. And interestingly found that metformin did was accompanied by a reduction in the prevalence of coronary calcium in men, not women. Dr. Ron Goldberg: And the effect was actually when we did subgroup analysis, we found it was particularly strong in young men. And actually that gave us some sense of optimism that we might see something when we came to actual events. And of course, as you all know, metformin has beneficial effects on several cardiovascular risk factors. And so the question is whether there is some effect of metformin that might yet be identified, a coronary calcium after all is a surrogate of events and may take time, or it may be that... And we are really interested in the idea that both prediabetes and diabetes are heterogeneous. There's more and more interest in looking at subgroups of individuals who may be more predisposed. And it may be that metformin might have beneficial effects in some of those subgroups. Dr. Hertzel Gerstein: But also remember on the other hand, there was a lot of co-intervention with metformin in all groups after the trial was over. So all groups were offered metformin, et cetera. So even if metformin had an effect, it could have easily been washed out by the exposure of all the other groups to metformin during follow up. But Ron, you also touched on both the hope and the frustration too, because if we start thinking about subgroups, we can always think of subgroups. Yeah. But then the problem with subgroups is you have a study, let's say you have a cohort study with 7,000 or 10,000 people and it followed for five years and, oh, well the effect isn't in all 10,000, it's only in 20% of them. So now you have a study of 2000 people, that's not enough to detect an effect in a subgroup. Dr. Hertzel Gerstein: So, subgroups just eat away at power in an exponential, not a linear way, so that you just rapidly lose any ability to detect anything. And so, yes, this is going to work in people with these three snips on this gene, in this subpopulation. Good luck, that's the difficulty and the challenge of... We need to find sometimes better or more efficient ways of identifying outcome protective therapies, because we can't keep drilling into some groups because we just don't have the resources to find it really. I don't know what other people feel about that, but. Dr. Carolyn Lam: I'm personally so enjoying this conversation as I know the audience is and we covered a lot. I'm sure everyone wants to pick up the paper and the editorial. Now, we talked about being underpowered for the number of studies. We talked about profitable dilution of things like statins, antihypertensive agents, even the crossover of potential treatment in the placebo arm and so on. And then we started talking about, or is it the how you got there and the drug that was used. And here, please don't shoot me, but I just know I have the answers on behalf of everyone else's thinking it. What do you say of people who go, "Well, it's because it's metformin. What if it was an SGLT2 inhibitor? What if it was a GLP-1 receptor agonist?" And as you know, a lot of people say those would in spite of the effect on glucose. Dr. Hertzel Gerstein: I can quickly jump in. It's very clear. We've learned this in the last 10 years, is that there are glucose lowering drugs and there are glucose lowering drugs with benefits. And the GLP-1 receptor agonist and the SGLT2 inhibitors are glucose lowering drugs with benefits. They lower glucose, but they seem to have a separate cardioprotective effect. And with the SGLT2 inhibitors that cardioprotective effect does not seem to be related to the glucose lowering. There are a few meta regression analyses that suggest that with the GLP-1 receptor agonist, part of the cardioprotective effect is related to glucose lowering and part is not. And clearly mediation analysis with some of the trials have shown the same thing with the GLP-1 receptor agonist, not really with the SGLT2 inhibitors. So, maybe, that's my spin on this. Dr. Carolyn Lam: Dr. Holman. Dr. Rury Holman: Yeah. I was going to echo what Hertzel said in that regard, these other agents do have multiple effects. They change weight, they change blood pressure. And so other risk factors are brought into play other than glucose lowerings. We've already agreed, glucose lowering impact on cardiovascular disease is quite modest. I'd rather have it than not, but it wouldn't be my primary way to treat cardiovascular disease. And coming back to Ron's study, which is crucial today, the issue here is whether we could untangle an impact particularly of metformin, which has been foundation drug for type 2 diabetes for so long. Dr. Rury Holman: But clearly within the dataset we have here, underpowered it is. There are no clear messages in that respect, which is disappointing, but it doesn't mean that there isn't an effect. With longer follow up, with more data than you might see it. When the study... I'm coming for you Hertzel, was stopped for futility then the hazard ratio has changed, that often the way, not for the right way, but it's often what happens when you stop studies. I wondered if you wanted to comment on that aspect, because I know it's something that you've talked a lot about. Dr. Carolyn Lam: Dr. Gerstein. Did you want to? Dr. Hertzel Gerstein: I agree with what Rury said. I think the point you're making Rury goes back to power, and the ability to have enough people and enough events to detect and effect and that's clearly true, so... Dr. Carolyn Lam: Well, I hate to be the one to break the party up, but we have gone over time and intentionally so, there's just so much learning here. But Dr. Goldberg, could I give you the last say please? What do you think is the important clinical take home message of your paper? Dr. Ron Goldberg: Well, I think that the fact that we demonstrated that our study has been able to maintain really low levels of cardiovascular risk factors, low levels of A1C, even though that likely contributed to the negative finding still leaves the physician where the recognition that it is important to identify individuals with prediabetes to Institute Diabetes Prevention Programs, because I think it's entirely possible as I said earlier, and we've begun to identify them, subgroups of individuals who do progress more rapidly and who do warrant a more effective treatment, which would come from an early intervention program. Dr. Carolyn Lam: Wow. Thank you so, so much for that. Thank you so much. All three gentlemen for this amazing discussion. Well, audience, you heard it right here on Circulation on the Run from Greg and I thank you for joining us today and don't forget to tune in again next week. Speaker 6: This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

Between girl bossing and hustle culture, it seems as though many of us have forgotten what rest looks like. Why are we doing so much? Working so hard? Trying to fill in the moments of 'nothing to do' with something to do? On this Deep Stretch episode of Inner Warmup, Taylor shares what Mental Health Awareness Month (May) looked like in her world. ‍This month, we've journeyed through The Five Dimensions of Wellbeing, saving the Wisdom Dimension for last. There's no moment to reflect at the end of this episode, but we're sure you'll do so anyhow. Grab your journal, warm up that tea for the sixth time today, and consider this: how would your life look and feel if you simply...did...less?Join the group chat: innerworkout.co/inner-working-group-chatShow notes:  innerworkout.co/post/less-pleaseFree self-care assessment: innerworkout.co/take-care-profileNewsletter: innerworkout.co/self-care-sundaysInstagram: @innerworkout | @taylorelysemorrison

This month, we've been moving through The Five Dimensions of Wellbeing and this week, we've arrived at the Bliss Dimension. The Bliss Dimension explores your connection to yourself and to the world around you through three sub-dimensions: connection to self, connection to community, and connection to something bigger. On this episode of Inner Warmup, Taylor helps you define the connections in your life that support your mental health.Join the group chat: innerworkout.co/inner-working-group-chatShow notes:  innerworkout.co/post/what-connections-support-my-mental-healthFree self-care assessment: innerworkout.co/take-care-profileNewsletter: innerworkout.co/self-care-sundaysInstagram: @innerworkout | @taylorelysemorrison

During the month of May, we'll be taking a look at The Five Dimensions of Wellbeing and how they relate to our mental health. Last week we discussed the energetic dimension, up next we have the mental and emotional dimension. Oftentimes, mental health conversations are focused on feelings, but on this episode of Inner Warmup, we're talking about the brain. If you're into neural pathways, pilates and The Ultimatum, you'll definitely want to take a listen. Also, there's still time to join the Scroll With Intention Challenge, sign up below! Let's take our power back from big tech and redefine our power of the scroll! Scroll With Intention Challenge begins today!Join the group chat: innerworkout.co/inner-working-group-chatShow notes:  innerworkout.co/post/is-your-brain-thrivingFree self-care assessmentNewsletter: innerworkout.co/self-care-sundaysInstagram: @innerworkout | @taylorelysemorrison

Happy May everyone! As you may already know, it's Mental Health Awareness month! Of course we had to put our own spin on things, so we'll be using this month to talk about multidimensional health with the help of The Five Dimensions of Wellbeing. Join on us on this journey as we take a dive into a different dimension each week of this month. If you want to deepen your understanding and relationship to your personal self-care journey, you can take our FREE Self-Care Assessment here! You may also consider joining us in the group chat or getting on the Scroll With Intention Challenge waitlist! At Inner Workout, it's all self-care, all the time!  On this episode, we're reclaiming our power of choice. You only get one life (so they say), we think it's best that you start making the best decisions for you. Get on the Scroll with Intention waitlistJoin the group chat: innerworkout.co/inner-working-group-chatShow notes:  innerworkout.co/post/where-can-you-reclaim-choiceFree self-care assessmentNewsletter: innerworkout.co/self-care-sundaysInstagram: @innerworkout | @taylorelysemorrison

Sarah Young explains why it's important to have a holistic and integrated view of intimacy beyond "just sex."

Description: Do you want to awaken your faith with a new freshness that is personal, passionate, and in partnership with the Holy Spirit? Join us this Sunday as Pastor Marty teaches us how to take our faith to the next level!

Today's guest, Taylor Morrison, is the founder of Inner Workout, a company that helps you practice self-care without the "should's." She describes self-care as "listening within and responding in the most loving way possible" (we love that definition!) and expands on how to practice it in this episode. When you tune in you'll learn: The power of presence as a foundation for discernment, especially when navigating uncomfortable moments in life The five dimensions of wellbeing, inspired by yoga's koshas How to assess your connection with the five dimensions, so that you can take intentional steps forward as it relates to wellbeing and self-care Why your wellness routines aren't meant to stick around forever and how your self-care practices may need to shift as your seasons and cycles change Taylor's perspective on what gets in the way of listening within and responding in the most loving way possible You don't need products to practice self-care, but they can be useful when they enhance or deepen your experience Resources mentioned: Inner Workout Website Inner Workout on Instagram (@innerworkout) Taylor Elyse Morrison on Instagram (@taylorelysemorrison) Discover your Take Care Profile here by taking the free self care assessment by Inner Workout Inner Warmup Podcast Shop Inner Workout's products Instead Deck Stasis Essential Oil Blend

Debbie A. Anderson is one of the leading authorities on spirit, the journey within and connecting with angels, guides, guardians and helpers who are there to assist all of us on our spiritual journey when we are open to receive their messages. Debbie shares some insights, tips and ways in which we can all connect to spirit and acknowledge how easy it is to do on a daily basis. Join us for the Quantum Guides Show!Debbie A. Anderson's Vibrational Energy Decks:• Vibrational Energy Oracle Deck – Created for adults. This beautifully illustrated deck of 52 cards comes with a detailed guide book that includes interpretations and Five Dimensions of the Vibrational Soul spread layout instructions, to help you to discover and unlock the secrets to your vibrational healing energy.http://www.vibrational-energy.com/vib... The video introduction to the Vibrational Energy Oracle Deck can be found at: http://youtu.be/8tTGynAbetI

In this episode, Andrea explains what are the five dimensions of great leadership based on his personal experience in helping executives and ambitious managers to raise their standards.By listening to the show, you'll learn:1) What are the five dimensions and why do they matter2) How to adapt and change your behaviors to score high across the five dimensions3) How to measure your current leadership level so you know where you need to focus on to get better results.To access the free assessment of the five dimensions, visit: www.andreapetrone.com/assessment.If you have any comment or insight about this episode, email Andrea at: andrea@andreapetrone.comFor more information about Andrea's work, go to:www.andreapetrone.comTo connect with Andrea on Social Media:LinkedIn - https://www.linkedin.com/in/andreapetrone/Twitter - https://twitter.com/ie_andrea Learn more about your ad choices. Visit megaphone.fm/adchoices

Sunday morning message from Pastor Chris Mathis | May 17/2020 Thank you for listening to this podcast from The Summit Edmonton Church. We hope you're blessed and encouraged by this message. If you'd like to learn more about The Summit Church, you can visit our website at: www.thesummitchurch.ca If you'd like to give, please go to: www.thesummitchurch.ca/give

In Episode 9, we are joined by Life Coach Jerry Davis and guest host/ friend of the show June. We discussed the (5) Five Dimensions of a Man as laid out in Coach Jerry's book, what men look for in a wife, and the age-old social media question; Who should eat first. This episode takes some hilarious turns so kick back and enjoy the show! Song of the week: Live, Love, Shine x Ace Hood Purchase the book on Amazon! Subscribe to our Youtube Channel! Follow us on social and keep the convo going on Facebook and Instagram Song of the week: Live, Love, Shine x Ace Hood --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app